Oral Maxillofac Surg Clin North Am. 2026 Feb 20:S1042-3699(25)00089-5. doi: 10.1016/j.coms.2025.12.003. Online ahead of print.
ABSTRACT
Gingivobuccal mucosal squamous cell carcinoma (GBMSCC) is a distinct head and neck cancer subtype strongly linked to areca nut and smokeless tobacco, often arising in a background of oral submucous fibrosis. Multiomics studies reveal recurrent mutations (TP53, FAT1, CASP8, PIK3CA, and AAM pathway genes), characteristic copy number alterations, and transcriptomic programs driven by extracellular matrix remodeling, epithelial-mesenchymal transition, and immune evasion. The tumor microenvironment is enriched with exhausted T cells, macrophages and cancer-associated fibroblasts. These insights support subsite-specific strategies incorporating targeted therapy, immunotherapy, chemoprevention, and saliva-based biomarkers for early detection, prognostication, surveillance, and improved clinical outcomes in GBMSCC.
PMID:41723026 | DOI:10.1016/j.coms.2025.12.003