Rev Med Chil. 2026 Jun;154(6):824-834. doi: 10.4067/s0034-98872026000600824.
ABSTRACT
Acute coronary syndrome (ACS) in adults aged 75 years and older poses a clinical challenge due to the high prevalence of comorbidities and the frequent exclusion of this population from clinical trials. In Chile, evidence regarding the characteristics and outcomes of this group is limited.
AIM: To describe the clinical and sociodemographic characteristics of patients aged ≥75 years with ACS undergoing coronary angiography at Dr. Hernán Henríquez Aravena Hospital (HHAH) between 2022 and 2023, and to evaluate the association of these variables with clinical outcomes.
METHODS: Observational cross-sectional study including patients aged ≥75 years admitted to the Hemodynamics Unit of HHAH between January 2022 and December 2023. Clinical and sociodemographic variables were collected. Outcomes included 30-day and one-year mortality, prolonged hospitalization, and post-event left ventricular ejection fraction (LVEF). Descriptive and comparative analyses were performed.
RESULTS: 300 patients were included. The mean age was 80.9 years; 63.7% were male, and 40.7% resided in rural areas. Hypertension and dyslipidemia were the most prevalent comorbidities, and multimorbidity reached 94.3%. The most frequent ACS subtype was non-ST-segment elevation myocardial infarction (NSTEMI). Atypical symptoms were present in 53.6% of patients, and 40.6% sought medical care more than 12 hours after symptom onset. Percutaneous coronary intervention was performed in 75.7% of cases. Mortality was 12.7% at 30 days and 31.3% at one year. Reduced post-event LVEF was associated with higher mortality.
CONCLUSIONS: This cohort showed a high burden of multimorbidity, delayed presentation, and substantial one-year mortality. The observed association between post-event LVEF and mortality should be interpreted with caution, given the methodological limitations of the study.
PMID:42585432 | DOI:10.4067/s0034-98872026000600824