Eur J Endocrinol. 2026 May 5:lvag076. doi: 10.1093/ejendo/lvag076. Online ahead of print.
ABSTRACT
CONTEXT: Magnesium deficiency is prevalent and increasingly recognized as an endocrine-relevant condition due to its involvement in hormone secretion, metabolic homeostasis, and cellular signaling.
OBJECTIVE: To review current evidence on the role of magnesium in key endocrine systems and evaluate its clinical and therapeutic implications.
EVIDENCE SYNTHESIS: Magnesium influences glucose metabolism, bone health, thyroid function, reproduction, cardiometabolic regulation, and HPA-axis activity. Clinical evidence shows strong associations between magnesium status and several endocrine diseases.
CONCLUSION: Magnesium plays a multifaceted endocrine role with clinically significant implications. Improved diagnostic approaches and further interventional studies are warranted.
PMID:42084330 | DOI:10.1093/ejendo/lvag076