Zhonghua Fu Chan Ke Za Zhi. 2026 Sep 25;61(9):717-723. doi: 10.3760/cma.j.cn112141-20260513-00258.
ABSTRACT
Objective: To investigate the management of pregnant women with positive anti-Ro/Sjögren's syndrome antigen A (SSA) antibody and (or) anti-La/Sjögren's syndrome antigen B (SSB) antibody complicated with fetal arrhythmia. Methods: Clinical data of pregnant women with positive anti-Ro/SSA and (or) anti-La/SSB antibodies complicated with fetal arrhythmia who delivered in Beijing Anzhen Hospital, Capital Medical University from January 2020 to June 2026 were retrospectively collected. Maternal autoantibody profiles, types of fetal arrhythmia and pregnancy outcomes were analyzed. Results: A total of 9 cases of pregnant women with positive anti-Ro/SSA and (or) anti-La/SSB antibodies complicated with fetal arrhythmia were included. All 9 cases were positive for anti-Ro/SSA antibody, including 6 strongly positive, 2 moderately positive and 1 weakly positive; among them, 6 cases were concomitantly positive for anti-La/SSB antibody. Among the 9 fetuses, 4 presented with third-degree atrioventricular block (AVB), 1 with first-degree AVB, 1 with transient bradycardia, 2 with supraventricular tachycardia, and 1 with atrial premature beats. Two cases of fetal third-degree AVB and one case of atrial premature beats failed to restore sinus rhythm after in utero pharmacological treatment, while one fetus with transient bradycardia and one fetus with supraventricular tachycardia achieved rhythm conversion after treatment. Among all 9 cases, 5 resulted in live births, including 4 cesarean deliveries and 1 vaginal delivery. Of these live-born infants, 2 were delivered at term and 3 were preterm. The other 4 pregnancies were terminated by induction of labor. Conclusions: AVB is the most common type of fetal arrhythmia induced by maternal positive anti-Ro/SSA and (or) anti-La/SSB antibodies. The utero pharmacological treatment is unlikely to reverse third-degree AVB in the fetus.
PMID:42802111 | DOI:10.3760/cma.j.cn112141-20260513-00258