iScience. 2026 Feb 17;29(3):115060. doi: 10.1016/j.isci.2026.115060. eCollection 2026 Mar 20.
ABSTRACT
Although the triglyceride-glucose index (TyG, insulin resistance) and remnant cholesterol (RC, lipid metabolism) are cardiovascular disease (CVD) risk factors in cardiovascular-kidney-metabolic (CKM) syndrome, their joint predictive power warrants further investigation. We utilized data from the China Health and Retirement Longitudinal Study (2020). Using participants with low TyG (<8.3) and low RC (<13.9) as the reference, individuals with both high TyG and high RC showed significantly elevated CVD risk. Over a median follow-up of 9.0 years, 1744 participants (23.2%) in CKM Stages 0-3 developed CVD. Participants with both high TyG and high RC had the highest risk (HR = 1.35). The TyG-RC index was created by multiplying TyG and RC. Each 1-SD increase in TyG-RC was associated with higher CVD risk, exhibiting an inverse J-shaped relationship. Time-independent ROC analysis demonstrated TyG-RC has superior predictive value compared to TyG-BMI, TyG-WC, TyG-WHtR, eGDR and METSIR. For enhanced CVD risk assessment, the joint assessment TyG-RC index offers a more effective tool than using TyG or RC individually.
PMID:41816296 | PMC:PMC12972743 | DOI:10.1016/j.isci.2026.115060