Cureus. 2025 Nov 29;17(11):e98076. doi: 10.7759/cureus.98076. eCollection 2025 Nov.
ABSTRACT
Systemic lupus erythematosus is an autoimmune disorder involving autoantibody production and immune complex-mediated damage of multiple organ systems, including the heart. The complex systemic manifestations of lupus and late detection of cardiovascular involvement make it difficult to isolate a singular mechanism that causes heart failure. We present a case of a young female patient presenting with systemic lupus nephritis and Stage 4 lupus nephritis found to have advanced heart failure and associated complications. This case highlights a young patient with lupus who developed heart failure likely due to myocarditis, underscoring the need for early cardiovascular monitoring and targeted research to improve outcomes in this high-risk population. Lupus leading to heart failure is likely caused by a multifaceted approach; further studies are needed to tailor treatment strategies for these patients that can reduce the risk of heart failure.
PMID:41477395 | PMC:PMC12750473 | DOI:10.7759/cureus.98076