Clin Lab. 2026 Jun 1;72(3). doi: 10.7754/Clin.Lab.2024.240809.
ABSTRACT
BACKGROUND: The aim of this study was to investigate the influencing factors and possible predictors of cognitive impairment in patients with type 2 diabetes mellitus complicating cerebral infarction (T2DM/CI).
METHODS: The clinical data of 130 patients with T2DM/CI were retrospectively analyzed. According to MMSE score and MoCA score, they were divided into cognitive impairment group (78 cases) and no cognitive impairment group (52 cases). Multifactorial logistic regression analysis was used to explore the independent influencing factors of cognitive impairment in patients with T2DM/CI. Pearson analysis was used to analyze the correlation between DBIL and HbA1c and MoCA score. In turn, ROC curves were plotted to analyze the predictive efficacy of DBIL and HbA1c in cognitive impairment in T2DM/CI patients.
RESULTS: DBIL in serum was significantly lower in the cognitive impairment group compared with the no cognitive impairment group and was an independent protective factor for cognitive impairment in T2DM/CI patients. In contrast, HbA1c levels were completely opposite and acted as an independent risk factor for cognitive impairment in patients with T2DM/CI. There was a negative correlation between MoCA scores and HbA1c as well as between HbA1c and DBIL. There was a positive correlation between MoCA scores and DBIL. Combined DBIL and HbA1c was more effective in predicting the cognitive impairment in patients with T2DM/CI.
CONCLUSIONS: Low DBIL and high HbA1c levels are independent risk factors for cognitive impairment in T2DM/ CI patients with some predictive efficacy and are positively correlated with the severity of cognitive impairment.
PMID:41945720 | DOI:10.7754/Clin.Lab.2024.240809