Profiles Drug Subst Excip Relat Methodol. 2026;51:211-252. doi: 10.1016/bs.podrm.2025.12.001. Epub 2026 Jan 3.
ABSTRACT
Perindopril (PER) is classified as angiotensin-converting enzyme (ACE) inhibitors and is used primarily for the management of hypertension and cardiovascular conditions, including heart failure and stable coronary artery disease. Two primary salts of PER have been developed, perindopril arginine (PER-Arg) and perindopril erbumine (PER-E). This chapter presents a detailed overview on the physicochemical attributes of PER-Arg, molecular structure, synthetic pathway, crystallographic behavior, thermal stability, and UV absorbance profile of PER-Arg. Moreover, the chromatographic, spectrophotometric, spectrofluorimetric, biosensors, and radioimmunoassay methodologies employed for quantifying PER-Arg and PER-E, both as a standalone compound and in combination with other drugs in various matrices, are thoroughly discussed.
PMID:41714068 | DOI:10.1016/bs.podrm.2025.12.001