Eur J Trauma Emerg Surg. 2026 Apr 27;52(1):148. doi: 10.1007/s00068-026-03195-4.
ABSTRACT
BACKGROUND: This study aims to evaluate the diagnostic significance of adrenomedullin and hypoxia-inducible factor 1 alpha (HIF1-alpha) levels in an animal model of acute mesenteric ischemia.
MATERIALS AND METHODS: In our study, a total of 21 male New Zealand rabbits were used, and the animals were divided into three groups for the study. Blood samples were taken for adrenomedullin and HIF1-alpha levels at 0, 1, 3, and 6 h from the control, sham, ischemia groups.
RESULTS: HIF levels of the ischemia group at the 3rd and 6th hours were statistically significantly higher than those in the sham (p = 0.002, p < 0.001, respectively) and control groups (p = 0.002, p < 0.001, respectively). Adrenomedullin levels of the ischemia group at the 1st, 3rd, and 6th hours were statistically significantly higher than those in the sham (p = 0.004, p < 0.001, p < 0.001, respectively) and control groups (p < 0.001, p < 0.001, p < 0.001 respectively).
CONCLUSION: In this experimental model of acute mesenteric ischemia, hypoxia-inducible factor-1 alpha and adrenomedullin levels were significantly higher in the ischemia group compared with the control and sham groups. Adrenomedullin demonstrated an earlier increase, while hypoxia-inducible factor-1 alpha increased significantly at later time points. These biomarkers may provide supportive diagnostic value when interpreted alongside clinical and imaging findings; however, further clinical studies are required to confirm their role in the early diagnosis of acute mesenteric ischemia.
PMID:42043510 | DOI:10.1007/s00068-026-03195-4