Front Cardiovasc Med. 2026 Apr 15;13:1752877. doi: 10.3389/fcvm.2026.1752877. eCollection 2026.
ABSTRACT
Cardiovascular diseases (CVD) stand as the primary cause of mortality and form the most prevalent disease category. Numerous studies have demonstrated that aging serves as a crucial pathogenic factor in the progression of CVD. Nevertheless, the molecular mechanisms underlying cardiovascular aging have not been fully elucidated. Research in various aging models has consistently shown that aging is attributed to the dysfunction of a complex transcriptional regulatory network that maintains the body's health, tissue homeostasis, and stress resistance. Transcription factors and chromatin regulatory factors are involved in almost all cellular activities, and an increasing amount of evidence indicates that as key regulatory elements, transcription factors and chromatin regulators control cellular senescence by regulating the transcription of related genes. Therefore, the aim of this review is to summarize the specific role of transcriptional regulation in the mechanism of cardiovascular aging, providing new strategies for the treatment of CVD.
PMID:42064852 | PMC:PMC13124636 | DOI:10.3389/fcvm.2026.1752877