Nephrol Dial Transplant. 2026 May 12:gfag107. doi: 10.1093/ndt/gfag107. Online ahead of print.
ABSTRACT
Coffee is one of the most widely consumed beverages globally. Caffeine has been linked to antioxidant, anti-inflammatory, antifibrotic, and anticancer effects. However, the relationship between caffeine consumption and the risk of chronic kidney disease (CKD) has yielded conflicting findings. Research on the health effects of caffeine relies mainly on exploratory observational studies, which may be affected by biases such as residual confounding. Variations in behaviour, health status, intake, and metabolism also influence outcomes. A comprehensive understanding of the mechanisms and population-specific factors mediating the impact of caffeine on kidney health is essential. In this article, we describe the metabolism and mechanism of action of caffeine, as well as its potential adverse effects. We synthesize current evidence and clarify the complex relationship between caffeine, CKD, and cardiovascular disease. Current evidence suggests that moderate caffeine intake is probably safe in CKD and may be potentially beneficial. Stronger evidence is needed before robust recommendations can be made for clinical practice.
PMID:42118061 | DOI:10.1093/ndt/gfag107