J Vis Exp. 2026 Jun 9;(232). doi: 10.3791/70915.
ABSTRACT
This study aimed to investigate the relationship between the atherogenic index of plasma (AIP) and hypertension in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). A total of 381 OSAHS patients admitted to the hospital from January 2023 to December 2025 were retrospectively enrolled and divided into a hypertension group (n = 161) and a non-hypertension group (n = 220). Univariate and binary logistic regression analyses were performed to identify influencing factors. The Receiver Operating Characteristic (ROC) curve is used to evaluate the discriminative ability of the identified hypertension indicators. Significant differences between the two groups were observed in coronary heart disease, chronic obstructive pulmonary disease, Gastric Burning, chronic rhinitis, chronic pharyngitis, alcohol consumption, smoking, sedative use, strong tea consumption, family history, neck circumference, red cell distribution width-standard deviation (RDW-SD), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and AIP (P < 0.05). Binary logistic regression indicated that both Coronary Heart Disease and AIP were independent factors for hypertension (P < 0.05). ROC analysis results showed that the AUC for AIP was 0.813 (95%CI: 0.767~0.859), with a standard error of 0.023 and Youden's index of 0.52, resulting in a sensitivity of 77.02% and specificity of 75.00%. These findings suggest that AIP was independently associated with the presence of hypertension in patients with OSAHS and showed moderate discriminatory ability for identifying patients with concomitant hypertension. However, the single-center design and limited sample size of this study warrant caution when generalizing the results.
PMID:42372024 | DOI:10.3791/70915