Commun Med (Lond). 2026 Jun 3. doi: 10.1038/s43856-026-01697-1. Online ahead of print.
ABSTRACT
BACKGROUND: While loss of Y chromosome (LOY), a common somatic alteration with aging, has been associated with cardiovascular diseases, its specific impact on ST-segment elevation myocardial infarction (STEMI) remains underexplored.
METHODS: This study enrolled 928 males undergoing primary percutaneous coronary intervention for STEMI to investigate the impact of LOY in blood cells on all-cause mortality. LOY was measured in males using droplet digital polymerase chain reaction technique. The primary outcome was all-cause mortality.
RESULTS: During a median of 3.99-year follow-up, 93 males (10.0%) died. Of these, 39 (4.2%) died within 1 year, 56 (6.0%) within 2 years, and 67 (7.2%) within 3 years. Compared to males with LOY < 18% (the 90th percentile), those with LOY ≥ 18% had an increased mortality after multivariable adjustment including age, with adjusted hazard ratios (HRs) of 2.45 (95% confidence interval [CI]: 1.16-5.15; P = 0.018), 2.11 (95% CI: 1.11-4.01; P = 0.024), and 1.88 (95% CI: 1.02-3.45; P = 0.043) at 1-, 2-, and 3-year follow-up, respectively. Among males without prior MI, those with LOY ≥ 18% have higher mortality than those with LOY < 18% (adjusted HR 1.93; 95% CI: 1.01-3.67; P = 0.045), whereas no significant association is observed in males with prior MI.
CONCLUSIONS: LOY ( ≥ 18%) is associated with an increased 1-, 2-, and 3-year mortality in male STEMI patients and may serve as a potential biomarker for risk stratification.
PMID:42236549 | DOI:10.1038/s43856-026-01697-1