Clin Rheumatol. 2026 Jun 13. doi: 10.1007/s10067-026-08217-5. Online ahead of print.
ABSTRACT
INTRODUCTION: Psoriatic arthritis (PsA), a chronic inflammatory disease associated with psoriasis, may be influenced by cardiovascular health (CVH). This study aims to investigate the associations between three CVH scores (Life's Simple 7 (LS7), Life's Essential 8 (LE8), and Life's Crucial 9 (LC9)) and a psychological health (PH) score with PsA risk and potential interactions with genetic susceptibility.
METHODS: Using data from the UK Biobank and NHANES cohorts, we conducted prospective and cross-sectional analyses employing Cox proportional hazards and multivariable logistic regression models, respectively. Additionally, a polygenic risk score (PRS) was derived in the UK Biobank to quantify genetic susceptibility to PsA and examine its interactions with CVH and PH metrics.
RESULTS: Higher scores in LE8, LC9, and PH showed consistent inverse associations with PsA, with the most pronounced association observed for LC9. Higher LC9 scores showed a strong inverse association with PsA (highest vs lowest group: OR = 0.25 (95% CI 0.05, 0.86), HR = 0.20 (95% CI 0.06, 0.65)). Each 10-point LC9 increase corresponded to lower PsA risk (OR = 0.76 (95% CI 0.58, 0.98), HR = 0.68 (95% CI 0.54, 0.86)). Genetic risk (assessed as the inverse of the PRS) showed significant antagonistic interactions with LE8, LC9, and PH scores.
CONCLUSION: Inverse associations were observed between LE8, LC9, and PH scores and PsA risk, along with notable interactions with genetic predisposition. Key Points • Higher LE8, LC9, and PH scores showed inverse associations with PsA. • LC9 showed the strongest inverse association with PsA in both cohorts. • Genetic susceptibility showed antagonistic interactions with LE8, LC9 and PH scores.
PMID:42286265 | DOI:10.1007/s10067-026-08217-5