Curr Ther Res Clin Exp. 2025 Dec 17;104:100817. doi: 10.1016/j.curtheres.2025.100817. eCollection 2026 Jun.
ABSTRACT
BACKGROUND: The rising global challenges of obesity and chronic inflammation contribute to an increased prevalence of metabolic disorders and cardiovascular diseases.
OBJECTIVE: The goal of the meta-analysis of randomized controlled trials (RCTs) was to assess the impact of yacon consumption on body weight and levels of C-reactive protein (CRP).
METHODS: Online databases such as PubMed/Medline, Scopus, Web of Science, and Google Scholar were searched until June 2024 to collect RCTs that investigated the impact of yacon consumption on body weight and CRP. Meta-analyses were conducted using a random-effects model, and the I 2 index was employed to evaluate the heterogeneity among the RCTs.
RESULTS: Seven studies with a total of 246 participants were included in the study. The pooled effect size indicated that yacon intake was associated with weight reduction (weighted mean difference [WMD], -8.22 kg; 95% CI, -16.01 to -0.43; P = .039). In contrast, yacon consumption showed no significant effects on body mass index (BMI) (WMD, -1.48 kg/m2; 95% CI, -4.11 to 1.14; P = .268), waist circumference (WC) (WMD, -3.73 cm; 95% CI, -10.18 to 2.72; P = .257), and CRP (WMD, -0.07 mg/L; 95% CI, -1.96 to 1.81; P = .939). Subgroup analyses demonstrated that yacon consumption led to significant weight reductions in individuals aged 40 years and older, as well as in women and those who consumed yacon for more than 8 weeks. Additionally, yacon consumption was associated with reductions in BMI and WC in women and individuals aged >40 years. However, no statistically significant differences were observed for other factors.
CONCLUSIONS: The findings suggest that yacon consumption may contribute to weight reduction in adults, though effects on BMI, WC, and CRP remain uncertain.
PMID:41685137 | PMC:PMC12890843 | DOI:10.1016/j.curtheres.2025.100817