Curr Cardiol Rev. 2026 Mar 27. doi: 10.2174/011573403X437559251128090907. Online ahead of print.
ABSTRACT
INTRODUCTION: Dietary fiber is a critical modulator of metabolic pathways underlying obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD).
METHODS: Literature published between 2000 and 2025 was systematically searched in PubMed, ScienceDirect, Google Scholar, Scopus, SpringerLink, and Wiley Online Library using keywords related to dietary fiber and metabolic diseases. Only peer-reviewed, open-access studies with mechanistic or clinical evidence were included.
RESULTS: Studies indicate that soluble, insoluble, and fermentable fibers confer protective effects against metabolic disorders through multiple mechanisms, including modulation of glycemic control, lipid metabolism, and inflammatory pathways.
DISCUSSION: Fermentation of dietary fiber by gut microbiota generates short-chain fatty acids, which improve insulin sensitivity, modulate lipid metabolism, and attenuate inflammation. Fiber also delays gastric emptying, enhances glycemic control, and lowers serum cholesterol. These physiological effects are supported by randomized controlled trials and meta-analyses demonstrating improvements in body weight, LDL cholesterol, and glucose regulation.
CONCLUSION: Incorporating dietary fiber into nutrition strategies effectively prevents and manages obesity, T2DM, and CVD, while further research is needed to understand individual variability in response.
PMID:41941345 | DOI:10.2174/011573403X437559251128090907