Metabolism. 2026 Aug 4:156724. doi: 10.1016/j.metabol.2026.156724. Online ahead of print.
ABSTRACT
BACKGROUND: Despite advances in managing traditional cardiovascular risk factors and promoting healthy lifestyles, recurrence of cardiovascular events remains high in patients with established coronary heart disease. Daytime napping, or siesta, has been associated with potential health benefits, but evidence in this population is still limited. This study aimed to evaluate associations between siesta habit and cardiometabolic health over a seven-year follow-up in patients with coronary heart disease from the CORDIOPREV study (NCT00924937).
METHODS: A total of 872 participants from the CORDIOPREV study were included with sufficient information collected throughout the 7-year follow-up to evaluate the siesta habit. The participants were stratified as "non-nappers", "short nappers" (≤30 min), and "long nappers" (>30 min). Blood pressure, anthropometric measures, and biological samples were taken at baseline and during yearly visits. Linear mixed models were performed to assess the evolution of cardiometabolic parameter over the follow-up.
RESULTS: Habitual short nappers showed lower weight, body mass index, and abdominal circumference, as well as lower fasting glucose, glycated hemoglobin, HOMA-IR, apolipoprotein B and triglyceride levels throughout the seven-year follow-up period with the most consistent differences observed in comparison with long nappers (p < 0.05). Stratified analyses by baseline diabetes status revealed in individuals without diabetes showed more favorable anthropometric measures than long nappers while within those with diabetes, short nappers showed more favorable glucose metabolism and triglyceride levels than long nappers.
CONCLUSIONS: Short siesta habit (≤30 min) was associated with a more favorable cardiometabolic profile in patients with CHD. Further studies are needed to assess its potential clinical relevance.
PMID:42551629 | DOI:10.1016/j.metabol.2026.156724