Taiwan J Ophthalmol. 2025 Jul 15;16(3):435-441. doi: 10.4103/tjo.TJO-D-25-00055. eCollection 2026 Jul-Sep.
ABSTRACT
PURPOSE: The aim of our study was to analyze the association between different cardiovascular risk scores and swept-source optical coherence tomography angiography (SS-OCTA) quantitative parameters in the general population.
MATERIALS AND METHODS: We performed a retrospective study. This study enrolled 111 eyes of 111 healthy patients. OCTA quantitative parameters (vessel density [VD] and foveal avascular zone area of superficial capillary plexus [SCP], deep capillary plexus [DCP], total capillary plexus, and choriocapillaris [CC]) of the OCTA cube of 4.5 mm × 4.5 mm were recorded.
RESULTS: A decrease of parafoveal and total VD in TCP was demonstrated in patients with higher cardiovascular risk (P < 0.05). Conversely, no differences were demonstrated in VD at SCP, DCP, and CC (P > 0.05). Correlation analysis showed a significant, although poor, negative correlation between parafoveal and total VD at SCP and TCP and 10-year cardiovascular disease (CVD) risk (P < 0.05 and r < 0.500).
CONCLUSION: When normative data are available, OCTA quantitative analysis might be used as a main tool for the primary prevention of CVD. Nevertheless, further prospective studies are needed to confirm this hypothesis.
PMID:42877907 | PMC:PMC13668187 | DOI:10.4103/tjo.TJO-D-25-00055