Front Mol Biosci. 2026 Jun 24;13:1818282. doi: 10.3389/fmolb.2026.1818282. eCollection 2026.
ABSTRACT
This mini-review describes the role of various parts of C. papaya L. (a member of the Caricaceae family) in the prevention and treatment of cardiovascular diseases (CVDs). C. papaya is mainly cultivated for its edible fruits, which are eaten fresh or made into candies, jams, drinks, or dried fruit. Not only fruits, but also other parts of this plant, including flowers, bark, and roots, have been traditionally used worldwide for the preparation of different medicinal preparations. For example, in traditional medicine, the fruit of C. papaya is used to normalize blood pressure due to its possible diuretic activity. The present mini-review paper also describes its cardioprotective potential in other details (not only anti-hypertensive activity). Moreover, cardioprotective mechanisms of the main bioactive compounds isolated from various parts of papaya were presented to provide a basis for further study and potential pharmacological use.
PMID:42422883 | PMC:PMC13341488 | DOI:10.3389/fmolb.2026.1818282