Zhonghua Liu Xing Bing Xue Za Zhi. 2026 May 10;47(5):916-920. doi: 10.3760/cma.j.cn112338-20250929-00692.
ABSTRACT
Objective: To describe the prevalence of chronic kidney disease (CKD) in adults in Anhui Province and evaluate the dose-response relationship between blood pressure (BP) and CKD. Methods: Based on multistage stratified cluster random sampling, China Chronic Disease and Risk Factor Surveillance was conducted in 12 prefectures of Anhui in 2023. A total of 7 597 permanent residents aged ≥18 years were recruited for questionnaire interviews, physical measurements, and laboratory tests. Logistic regression combined with restricted cubic splines (RCS) was used to evaluate the association between BP and CKD. Results: After exclusion, 7 346 participants were included in the final analysis. The analysis indicated that the weighted prevalence of CKD was 11.7% (95%CI: 9.9%-13.6%) in adults, with 11.4% (95%CI: 9.2%-13.5%) in men and 12.1% (95%CI: 9.4%-14.9%) in women, in Anhui in 2023. After adjustment for relevant confounders, compared with individuals with SBP <130 mmHg, the odds ratios for CKD were 1.72 (95%CI: 1.45-2.05) time, 2.00 (95%CI: 1.62-2.49) time, and 3.24 (95%CI: 2.38-4.41) time in those with SBP 140-, 160-, and ≥180 mmHg, respectively. Compared with individuals with DBP <80 mmHg, the odds ratios for CKD were 1.20 (95%CI: 1.04-1.39) time, 1.39 (95%CI: 1.15-1.68) time, 1.72 (95%CI: 1.25-2.35) time, and 2.69 (95%CI: 1.46-4.96) time in those with DBP 80-, 90-, 100-, and ≥110 mmHg. RCS analyses revealed linear dose-response relationships of SBP and DBP with CKD. Below 130/80 mmHg, the risk for CKD remained relatively low, whereas once blood pressure reached or exceeded 130/80 mmHg, the risk for CKD increased obviously. Conclusion: Elevated blood pressure might be a key risk factor for the onset of CKD, and blood pressure level at 130/80 mmHg might indicate that it is necessary to conduct intervention for CKD prevention.
PMID:42151072 | DOI:10.3760/cma.j.cn112338-20250929-00692