Circulation. 2026 Jan 13;153(2):115-131. doi: 10.1161/CIRCULATIONAHA.125.075978. Epub 2026 Jan 12.
ABSTRACT
Many patients with severe aortic stenosis present with concomitant multivalvular heart disease. The management of this condition remains challenging and requires a multidisciplinary approach that integrates clinical, hemodynamic, and multimodality imaging data to define the most effective and durable treatment strategy. Although randomized evidence to guide treatment decisions in this setting is limited, percutaneous interventions to address additional valvular lesions are being increasingly adopted. This review provides an overview of the pathophysiology of valvular diseases commonly associated with severe aortic stenosis, highlighting their prognostic implications after surgical or transcatheter treatment and their impact on risk stratification and therapeutic management.
PMID:41525437 | DOI:10.1161/CIRCULATIONAHA.125.075978