Am J Physiol Cell Physiol. 2026 Jul 29. doi: 10.1152/ajpcell.00230.2026. Online ahead of print.
ABSTRACT
Diabetic cardiomyopathy (DCM) is a major complication of type 2 diabetes mellitus and a leading contributor to heart failure. A central feature of DCM is the disruption of mitochondrial bioenergetics and calcium homeostasis, processes that are tightly regulated through mitochondria-associated endoplasmic reticulum membranes (MAMs). These ER-mitochondria contact sites coordinate mitochondrial ion transport systems, including the mitochondrial calcium uniporter (MCU), Na⁺/Ca²⁺ exchanger (NCLX), and potassium channels, which collectively govern mitochondrial metabolism, redox balance, and cell survival.
PMID:42526021 | DOI:10.1152/ajpcell.00230.2026