Rev Neurol. 2025 Nov 30;80(10):40923. doi: 10.31083/RN40923.
ABSTRACT
OBJECTIVES: There are inherent risks associated with intravenous thrombolysis (IVT) therapy in patients with acute ischemic stroke (AIS). The atherogenic index of plasma (AIP), defined as log (triglyceride [TG]/high-density lipoprotein cholesterol [HDL-C]), has recently been associated with the prognosis. We aimed to gauge AIP prognostic value in AIS patients receiving IVT.
METHODS: We retrospectively collected data from 183 AIS patients who underwent IVT. We grouped modified Rankin Scale scores of 0-2 and 3-6 as good and poor outcomes at 1 year, respectively. Multivariate logistic regression, receiver operating characteristic (ROC) curve and restricted cubic spline (RCS) analyses were used to investigate the underlying link between the AIP and 1-year functional outcomes.
RESULTS: In this study, 67 patients (36.6%) exhibited poor 1-year outcomes. An optimal AIP cut-off of 0.188 was used to divide the patients into low and high AIP levels. Our results showed that continuous AIP (odds ratio [OR] = 25.10, 95% confidence interval [CI]: 4.86-129.68, p < 0.001) was associated with poor 1-year outcome; when AIP was as a categorical variable, OR (95% CI) for the prognosis in the high AIP group was 27.86 (9.33-83.25) compared with the low AIP group. ROC analyses revealed that the area under the ROC curve for the AIP was 0.694 (0.603-0.785), with a sensitivity of 87.1% and a specificity of 61.2%. In the fully adjusted RCS, we found a positive but non-linear trend between the AIP and prognosis.
CONCLUSIONS: High AIP may offer potential value as a novel target for predicting 1-year outcomes in patients receiving IVT.
PMID:41351390 | DOI:10.31083/RN40923