Eur J Nutr. 2025 Dec 6;65(1):5. doi: 10.1007/s00394-025-03849-w.
ABSTRACT
PURPOSE: to evaluate the effects of three interventions (conventional yogurt; probiotic yogurt, and isolated probiotic) on bone and heart parameters in a chronic kidney disease (CKD) model.
METHODS: male Wistar rats were divided into 4 groups: Nephrectomized Group (Nx, n = 8); Nx + Yogurt Group (NxY, n = 8); Nx + Probiotic-enriched Yogurt Group (NxPY, n = 8) and Nx + Probiotic Group (NxP, n = 8). Lactobacillus acidophilus La-05 (108 -109 log CFU/mL) was used as a probiotic. Cardiac electrical activity was measured by electrocardiogram, and body composition was measured using dual-energy X-ray absorptiometry. Additional measurements included bone biomechanical and atherogenic parameters, histomorphometry of the heart and aorta, hypertrophy, oxidative stress, inflammation parameters, and p-cresyl sulfate (pCS) levels.
RESULTS: The NxPY group presented improvements in tibia parameters such as maximum strength (p = 0.02), maximum tension (p = 0.02), and breaking tension (p = 0.04) than the Nx group. On the other hand, NxY and NxP did not affect bone parameters. The NxPY group showed lower heart relative weight than the NxP group (p = 0.007). In the electrocardiogram, NxPY demonstrated shorter T wave duration (p = 0.002), QT (p = 0.006), and QTc (p = 0.003) interval duration compared to NxP. NxP worsened cardiac electrical activity as the increase in T wave duration (p = 0.03), QTc interval (p = 0.02), ST segment amplitude (p = 0.01), and raised cardiac hypertrophy including heart weight corrected for tibia length (p = 0.04) compared to Nx. Meanwhile, no significant difference was found between the NxY and Nx groups. Also, there were no significant differences in pCS levels among the groups Nx, NxY, NxPY and, NxP.
CONCLUSION: This is the first study to compare these effects and revealed that supplementation of Lactobacillus acidophilus La‑05-enriched yogurt improved bone parameters, while isolated probiotic impaired electrical conduction and aggravated hypertrophy in the heart. On the other hand, conventional yogurt did not affect bone or heart parameters. These findings may help guide future clinical studies and recommendations, mainly about dairy products and probiotics in CKD.
PMID:41351641 | DOI:10.1007/s00394-025-03849-w