Cancer Epidemiol Biomarkers Prev. 2026 Oct 28. doi: 10.1158/1055-9965.EPI-26-0848. Online ahead of print.
ABSTRACT
BACKGROUND: This study characterized beliefs about hereditary susceptibility to cancer and desire to know about a genetic predisposition to cancer in a nationally representative survey of US adults.
METHODS: Adjusted regression models using weighted survey analysis of NCI HINTS 2020 data assessed predictors of how much respondents (1) believe genes that are inherited determine whether a person will develop cancer and (2) would want to know if they had a genetic change that increases their chance of getting cancer.
RESULTS: On average, respondents endorsed between "somewhat" and "a lot" for how much hereditary susceptibility determines cancer risk. Respondents believed that hereditary susceptibility to cancer, cardiovascular disease, and diabetes were similar (Means= 1.83-1.85, all p>0.6). Individuals who had health insurance (β=-0.42 - -0.37, p=0.017-0.021) and previously sought cancer information (β=-0.19, p<0.001) believed in greater hereditary susceptibility to cancer, whereas those who self-reported good health believed in less hereditary susceptibility to cancer (β=0.16, p=0.022). Individuals who believed in greater hereditary susceptibility to cancer (β=0.14, p=0.001), previously sought cancer information (β=-0.19, p=0.002), had a family history of cancer (β=-0.19, p=0.005), were less fatalistic (β=-0.08, p=0.036), and were Hispanic (β=-0.25, p=.009) or Black (β=-0.47, p<0.001) endorsed a greater desire to know about a genetic predisposition to cancer.
CONCLUSIONS: Efforts are needed to improve understanding of hereditary susceptibility, address fatalistic beliefs and misinformation, facilitate disclosure of family cancer history indicative of a potential genetic predisposition to cancer.
IMPACT: Efforts are needed to improve access to genetic counseling and testing through education and targeted interventions.
PMID:42949762 | DOI:10.1158/1055-9965.EPI-26-0848