Res Pract Thromb Haemost. 2026 Sep 11;10(6):106951. doi: 10.1016/j.rpth.2026.106951. eCollection 2026 Aug.
ABSTRACT
BACKGROUND: The optimal management of isolated tumor thrombus (TT) remains unknown. Although therapeutic anticoagulation is indicated for concurrent bland thrombosis or history of venous thromboembolism, current guidelines do not specifically address isolated TT, and recent studies have not shown consistent benefit of anticoagulation in this setting.
OBJECTIVES: This study described the characteristics of patients with isolated TT managed at Gustave Roussy Comprehensive Cancer Center for over 5 years and explored outcomes, including overall survival, thrombotic events, and bleeding, across different anticoagulation strategies.
METHODS: This retrospective single-center cohort study included consecutive adults with imaging-confirmed isolated TT managed at Gustave Roussy from November, 2018 to June, 2024. Patients receiving therapeutic anticoagulation for any indication were excluded. The primary outcome was overall survival. Secondary outcomes were incident thromboembolic events and bleeding.
RESULTS: Among 1262 screened records, 29 patients with isolated TT met eligibility criteria (mean age 55.6 ± 15.7 years; 75.9% male; 93.1% had stage IV cancer). Ten received prophylactic-dose anticoagulation, and 19 received no anticoagulation. Restricted mean overall survival was 50.7 months (95% CI, 43.3-58.06) in the prophylactic anticoagulation group vs 20.8 months (95% CI, 10.8-30.9) in the no-anticoagulation group. New bland thrombosis and bleeding events were infrequent and did not differ significantly between groups.
CONCLUSION: In this small retrospective cohort, longer survival was observed in patients receiving prophylactic-dose anticoagulation. This finding may reflect residual confounding and selection of patients with more favorable prognosis rather than a true therapeutic effect and should therefore be interpreted with considerable caution.
PMID:42908642 | PMC:PMC13683023 | DOI:10.1016/j.rpth.2026.106951