Diabetes. 2026 Oct 29:db260184. doi: 10.2337/db26-0184. Online ahead of print.
ABSTRACT
The biological mechanisms of how sleep duration impacts type 2 diabetes pathogenesis and glycemic control are unclear. This study reveals 16 loci (11 novel) that interact with either short or long sleep duration to influence hemoglobin A1c, fasting glucose, or fasting insulin. Short and long sleep duration loci were nonoverlapping. Regulation of copper and diacylglycerol levels appear as distinct cellular mechanisms implicated by long and short sleep duration loci, respectively. Identified gene targets present insight for potential type 2 diabetes therapeutic design approaches related to JIP1-c-Jun N-terminal kinase interaction disruption, pericyte health, N-methyl-d-aspartate receptor activity, anti-inflammatory and leptin-enhancing dietary supplements, and serpins.
PMID:42954775 | DOI:10.2337/db26-0184