Impaired Placental Vascular Reactivity in Congenital Heart Disease Quantified Using Blood Oxygen Level-Dependent MRI

Magn Reson Med. 2025 Nov 2. doi: 10.1002/mrm.70159. Online ahead of print.ABSTRACTPURPOSE: Placental pathology is directly associated with adverse fetal outcomes congenital heart disease (CHD). However, in vivo placental dysfunction has been poorly characterized. We aimed to compare placental vascul

V Vidya Rajagopalan

Revisiting signal intensity ratios for extending the dynamic range for iron overload estimation

Magn Reson Med. 2025 Nov 2. doi: 10.1002/mrm.70078. Online ahead of print.ABSTRACTPURPOSE: The principles of signal-intensity-ratio (SIR) estimation were revisited to derive a set of generalizable equations to quantify liver iron concentration (LIC), extending the effective dynamic range of LIC-R2*

E Eamon K Doyle

Diagnosis and treatment in adult patients with C3 glomerulopathy in Japan: a real-world survey

Clin Exp Nephrol. 2025 Nov 3. doi: 10.1007/s10157-025-02779-5. Online ahead of print.ABSTRACTINTRODUCTION: C3 glomerulopathy (C3G) is an ultra-rare, complex, under-recognized kidney disease with a challenging diagnosis and no approved treatment. Nephrologists were surveyed to understand the treatmen

N Naoki Nakagawa

Integrated Bioinformatic Analysis of the Shared Molecular Mechanisms Between Osteoporosis and Aortic Stenosis

Curr Med Chem. 2025 Oct 29. doi: 10.2174/0109298673382922250915061033. Online ahead of print.ABSTRACTINTRODUCTION: Osteoporosis (OP) and aortic stenosis (AS) are highly prevalent age-related disorders that frequently coexist. Epidemiological studies suggest a pathological link between OP and AS beyo

Y Yue-Jiao Yang

Effects of SGLT2 Inhibitors on Circulating Cyclophilin A Levels in Patients with Type 2 Diabetes

Curr Med Chem. 2025 Oct 29. doi: 10.2174/0109298673406989251010070419. Online ahead of print.ABSTRACTOBJECTIVE: This study aimed to evaluate cyclophilin (CypA) levels in patients with diabetes mellitus (DM) before and after treatment. Metabolic variables, such as weight, blood pressure, and plasma g

F Furkan Kılıç

Annular Aortic Valve Enlargement Versus Transcatheter Aortic Valve Replacement in Women With Small Aortic Annulus: Contemporary Evidence, Challenges, and Future Directions

Cardiol Rev. 2025 Oct 20. doi: 10.1097/CRD.0000000000001072. Online ahead of print.ABSTRACTWomen with severe aortic stenosis frequently have small aortic annuli, predisposing them to prosthesis-patient mismatch after valve replacement. Surgical annular aortic valve enlargement (AAVE) during aortic v

R Rimsha Ahmad

Baseline and long-term frailty transitions and rapid estimated glomerular filtration rate decline: evidence from two large population-based studies

Ren Fail. 2025 Dec;47(1):2577839. doi: 10.1080/0886022X.2025.2577839. Epub 2025 Nov 2.ABSTRACTFrailty is widely recognized to be associated with kidney function decline, but its longitudinal relationship with rapid estimated glomerular filtration rate (eGFR) decline remains unclear. This study exami

Y Ying Deng

Substrate Stiffness Attenuates Cardiomyocyte Depolarization Slope via Sodium Channel Kinetics Modulation

Arch Biochem Biophys. 2025 Oct 31:110668. doi: 10.1016/j.abb.2025.110668. Online ahead of print.ABSTRACTBACKGROUND: The excessive deposition of extracellular matrix (ECM) components in cardiac tissue increases myocardial stiffness, contributing to diastolic dysfunction and arrhythmia risk. While thi

Y Yuan Zhu

Atlas-independent brain connectome analysis at voxel-level granularity: graph convolutional networks for etiology classification in newborns

Neuroimage. 2025 Oct 31:121568. doi: 10.1016/j.neuroimage.2025.121568. Online ahead of print.ABSTRACTEarly identification of altered brain networks in neonates at risk for neurodevelopmental impairments is critical for timely intervention and improving outcomes. This study explores the potential of

A Anna Speckert

Left ventricular diastolic function modifies clinical outcomes of mild mitral regurgitation

Int J Cardiol. 2025 Oct 31:133998. doi: 10.1016/j.ijcard.2025.133998. Online ahead of print.ABSTRACTBACKGROUND: Current guidelines regard mild mitral regurgitation (MMR) as a benign condition and do not recommend risk stratification. Little is known about the interplay between MMR and left ventricul

P Peihan Xie

IGF-1 promotes cell surface expression of HCN4 pacemaker channels contributing to tachycardia

J Mol Cell Cardiol. 2025 Oct 31:S0022-2828(25)00199-3. doi: 10.1016/j.yjmcc.2025.10.015. Online ahead of print.ABSTRACTInsulin-like growth factor 1 (IGF-1) controls cardiac growth, metabolism, and contractility. Whereas IGF-1 deficiency is associated with cardiovascular risk, the activation of its s

N Nadine Erlenhardt

Circulating microRNAs in viral myocarditis: Advancements in biological understanding and potential clinical applications

Gene. 2025 Oct 31:149866. doi: 10.1016/j.gene.2025.149866. Online ahead of print.ABSTRACTViral myocarditis (VMC) is a prevalent inflammatory cardiac condition, characterized by highly variable clinical manifestations that present significant challenges for early diagnosis and the development of pers

M Ming-Ren Ma

When Bad Things Happen to Good Hearts Prediction and Management of Primary Graft Dysfunction

Can J Cardiol. 2025 Oct 31:S0828-282X(25)01290-5. doi: 10.1016/j.cjca.2025.10.031. Online ahead of print.ABSTRACTPrimary graft dysfunction (PGD) occurs in nearly 8-10% of heart transplant (HT) recipients, and is the most consequential early complication with an associated reduction in 1 year surviva

N Nitish K Dhingra

Distance from pacing lead tip to left ventricular cavity predicts long-term loss of left bundle branch capture: Insights from the IMAGE-LBBP cohort

Can J Cardiol. 2025 Oct 31:S0828-282X(25)01291-7. doi: 10.1016/j.cjca.2025.10.032. Online ahead of print.ABSTRACTBACKGROUND: Left bundle branch pacing (LBBP) has been an emerging pacing modality that preserves physiological activation. However, data on the long-term durability of conduction system c

M Mengxing Cai

Infective endocarditis after transcatheter aortic valve implantation: Current challenges in diagnosis, management and prevention

Can J Cardiol. 2025 Oct 31:S0828-282X(25)01289-9. doi: 10.1016/j.cjca.2025.10.030. Online ahead of print.ABSTRACTThe worldwide use of transcatheter aortic valve implantation (TAVI) is increasing due to an aging population and proven cost-effectiveness. As a result, the incidence of infective endocar

J Javier Iglesias-Varea

Preference-based controlled design: toward increased patients' engagement, efficiency and external validity of cardiovascular clinical trials

J Clin Epidemiol. 2025 Oct 31:112039. doi: 10.1016/j.jclinepi.2025.112039. Online ahead of print.ABSTRACTRandomized controlled trials (RCTs) are the gold standard for evaluating clinical interventions, but their limitations-particularly in settings where strong patient preferences exist-can impair r

B Bjorn Redfors

Decreased Risk of Cardiovascular Disease in Dermatology Patients Taking Niacinamide: A TriNetX Cohort study

J Am Acad Dermatol. 2025 Oct 31:S0190-9622(25)03115-9. doi: 10.1016/j.jaad.2025.10.115. Online ahead of print.ABSTRACTBACKGROUND: Niacinamide is frequently used for non-melanoma skin cancer (NMSC) chemoprophylaxis. Recent studies raised concerns about cardiovascular risk associated with niacin metab

Y Yousef Salem

Prognostic Value of Left Atrial Strain for Systemic Embolism in Rheumatic Mitral Stenosis with Sinus Rhythm: Implications for Anticoagulation Strategy

J Am Soc Echocardiogr. 2025 Oct 31:S0894-7317(25)00605-4. doi: 10.1016/j.echo.2025.10.014. Online ahead of print.ABSTRACTAIMS: Stroke and systemic embolism are important complications of rheumatic mitral stenosis (MS) even if sinus rhythm (SR) is maintained. We sought to identify the risk factors fo

I Iksung Cho

Threshold Values of the Vena Contracta Area for Grading Secondary Tricuspid Regurgitation and its Association with Outcomes

J Am Soc Echocardiogr. 2025 Oct 31:S0894-7317(25)00607-8. doi: 10.1016/j.echo.2025.10.015. Online ahead of print.ABSTRACTBACKGROUND: Three-dimensional echocardiographic (3DE) planimetry of the vena contracta area (VCA), which avoids geometric assumptions about the regurgitant orifice, has emerged as

G Giorgia Benzoni

Left ventricular dysfunction after pacemaker implantation: who could benefit from upfront conduction system pacing?

Heart Rhythm. 2025 Oct 31:S1547-5271(25)03032-2. doi: 10.1016/j.hrthm.2025.10.051. Online ahead of print.ABSTRACTBACKGROUND: Pacing-induced cardiomyopathy (PICM) is a recognized complication following pacemaker implantation and is associated with worse prognosis.OBJECTIVE: This study aimed to examin

J Jordi Lozano-Torres

Association of blood inflammatory biomarkers with the incidence of atrial fibrillation among senior adults: an eight-year prospective cohort study

Heart Rhythm. 2025 Oct 31:S1547-5271(25)03035-8. doi: 10.1016/j.hrthm.2025.10.054. Online ahead of print.ABSTRACTBACKGROUND: The effect of blood inflammatory biomarkers on atrial fibrillation (AF) incidence remains unclear.OBJECTIVE: This study was to examine the effect of inflammatory biomarkers on

Z Zuyi Feng

Cardiac sympathetic denervation for refractory ventricular arrhythmias in patients with inherited cardiomyopathies

Heart Rhythm. 2025 Oct 31:S1547-5271(25)03037-1. doi: 10.1016/j.hrthm.2025.10.056. Online ahead of print.ABSTRACTBACKGROUND: Cardiac Sympathetic Denervation (CSD) is a therapeutic option in patients with recurrent or refractory ventricular arrhythmia (VA). Successful outcomes have largely been estab

A Abdullah Sarkar

Catheter Ablation is Associated with Reduced Cardiovascular Events in Atrial Fibrillation Patients with Atrial Functional Mitral Regurgitation

Heart Rhythm. 2025 Oct 31:S1547-5271(25)03031-0. doi: 10.1016/j.hrthm.2025.10.050. Online ahead of print.ABSTRACTBACKGROUND: Atrial functional mitral regurgitation (AFMR) frequently occurs secondary to atrial fibrillation (AF). Although prior studies reported improvement in AFMR severity after cathe

Q Qifan Li

The Society of Thoracic Surgeons Intermacs 2025 Annual Report: Focus on Outcomes in Older Adults

The 16^(th) Annual Report from the Society of Thoracic Surgeons (STS) Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs) includes 28,029 continuous-flow left ventricular assist devices (CF LVAD) implanted from 2015 to 2024. Survival remains excellent with the fully magnet

A Aditi Nayak