FUBP3 mediates MXI1 stability to silence RRAS and hinder MAPK signaling in acute megakaryoblastic leukemia progression

Cancer Immunol Immunother. 2025 Dec 22;75(1):23. doi: 10.1007/s00262-025-04257-z.ABSTRACTRRAS, a gene encoding a small monomeric GTPase that controls cell adhesion and migration, has been linked to leukemogenesis. However, its function in acute megakaryoblastic leukemia (AMKL), a rare type of acute

Y Ying Zhu

Cardiac structure and systolic function in resistance-trained athletes versus untrained male adults

Eur J Appl Physiol. 2025 Dec 22. doi: 10.1007/s00421-025-06060-1. Online ahead of print.ABSTRACTPURPOSE: Research examining the Athlete's Heart has often focused on endurance athletes, yet no clear consensus has emerged on the cardiac adaptations observed in resistance-trained athletes. The purpose

A Abigail M Saunders

Reversing frailty: The transformative effects of structured physical-activity-based physiotherapy on physical, cognitive and emotional health in older adults-An evidence-based systematic review

Eur J Clin Invest. 2025 Dec 22:e70158. doi: 10.1111/eci.70158. Online ahead of print.ABSTRACTBACKGROUND: Elderly frailty is a multifaceted clinical condition with diminished physiological reserves and increased stress susceptibility. It increases disability, hospitalization and mortality rates, requ

M Moattar Raza Rizvi

Padua Days on Muscle and Mobility Medicine, March 3-6, 2026: Call for oral presentations

Eur J Transl Myol. 2025 Dec 19;35(4). doi: 10.4081/ejtm.2025.14667. Epub 2025 Dec 2.ABSTRACTThe Padova Muscle Days (PMD), an international congress on skeletal muscle, was founded in 1985 to provide consultancy on Translational Myology. Its goal has always been to translate the results of basic rese

U Ugo Carraro

Home mechanical ventilation in adults: Clinical practice recommendations from the Portuguese Respiratory Society home mechanical ventilation assembly

Pulmonology. 2025 Dec 31;31(1):2598915. doi: 10.1080/25310429.2025.2598915. Epub 2025 Dec 22.ABSTRACTBackground: The use of home mechanical ventilation (HMV) has been increasing worldwide, driven by widening of clinical applications and improved patient survival rates. In Portugal, recent data indic

C Carla Ribeiro

The Role of Sauna Bathing in Ischemic Heart Disease: A Narrative Review of Therapeutic Potential, Physiological Mechanisms, and Emerging Clinical Applications

Cureus. 2025 Nov 30;17(11):e98162. doi: 10.7759/cureus.98162. eCollection 2025 Nov.ABSTRACTIschemic heart disease (IHD) continues to be one of the main causes of morbidity and mortality among the general adult population. It occurs due to a lack of sufficient coronary blood flow. Sauna bathing has r

G Georges Hachem

Lean on me: attachment and mental health in couples facing cardiovascular disease

Front Psychol. 2025 Dec 4;16:1657068. doi: 10.3389/fpsyg.2025.1657068. eCollection 2025.ABSTRACTElevated symptoms of depression and anxiety are common after the onset of cardiovascular disease in both patients and their spouses. Attachment anxiety, attachment avoidance, and the degree to which coupl

K Karolina Sztajerowski

Differential risk of adverse drug reactions with baricitinib across age groups: integrating real-world pharmacovigilance and genetic causal inference

Ther Adv Drug Saf. 2025 Dec 18;16:20420986251406106. doi: 10.1177/20420986251406106. eCollection 2025.ABSTRACTBACKGROUND: Baricitinib is widely used for immune-mediated diseases, yet real-world safety in underrepresented age groups and the temporal dynamics of adverse drug reactions (ADRs) remain in

H Huiqiong Zeng

The Effects of Cardiopulmonary Pre-Rehabilitation on Physical Performance, Balance, and Fear of Falling Among the Candidates for Coronary Artery Bypass Graft Surgery

SAGE Open Nurs. 2025 Dec 18;11:23779608251407768. doi: 10.1177/23779608251407768. eCollection 2025 Jan-Dec.ABSTRACTINTRODUCTION: Patients awaiting heart surgery often experience reduced physical activity, leading to decreased muscle mass, strength, and endurance.OBJECTIVES: This study aimed to evalu

Z Zoleikha Abbasi

Impact of Sedentary Time and Physical Function on Health-Related Quality of Life in Hospitalized Patients with Cardiovascular Disease

CJC Open. 2025 Aug 22;7(11):1524-1532. doi: 10.1016/j.cjco.2025.08.004. eCollection 2025 Nov.ABSTRACTBACKGROUND: This study investigated the association between health-related quality of life (HRQOL), sedentary time, and physical function in hospitalized patients with cardiovascular disease (CVD) un

K Kazuhiro P Izawa

Digital adaptation of the clinically effective REACH-HF home-based cardiac rehabilitation programme for people living with heart failure (D:REACH-HF)

Digit Health. 2025 Dec 18;11:20552076251406545. doi: 10.1177/20552076251406545. eCollection 2025 Jan-Dec.ABSTRACTBACKGROUND: Despite strong recommendations for heart failure (HF) rehabilitation, participation (uptake and sustained engagement) remains low. Digital interventions may enhance participat

S Samantha B van Beurden

A food-medicine homology formulation ameliorates atherosclerosis by attenuating dyslipidemia and inflammation via the PI3K/Akt/NF-κB pathway

Front Pharmacol. 2025 Dec 4;16:1710585. doi: 10.3389/fphar.2025.1710585. eCollection 2025.ABSTRACTBACKGROUND: Atherosclerosis (AS), a chronic inflammatory condition of the vasculature, is a major contributor to cardiovascular morbidity. Yaoshi Tongyuan Tablet (YTT) is a food-medicine homology (FMH)

Y Yadong Zheng

Green Mediation and Chemical Characterization of Iron Nanoparticles by Lavandula angustifolia for the Treatment of Myocardial Infarction and Arrhythmia

J Biomed Mater Res B Appl Biomater. 2026 Jan;114(1):e70005. doi: 10.1002/jbmb.70005.ABSTRACTIn this work, a green formulation of iron nanoparticles (FeNPs) using Lavandula angustifolia leaf extract was described. FeNPs were described using several spectroscopic approaches, and their efficacy in trea

Y Yunpeng Li

Quantitative Magnetic Resonance Imaging of Gluteal Muscle Groups Detects Stage-Specific Progression and Early-Stage Damage in Duchenne Muscular Dystrophy: A 12-Month Longitudinal Study

Muscle Nerve. 2025 Dec 22. doi: 10.1002/mus.70115. Online ahead of print.ABSTRACTINTRODUCTION/AIMS: Quantitative MRI (qMRI) of gluteal muscle groups for Duchenne muscular dystrophy (DMD) progression requires sensitive biomarkers and stage-specific validation. This 12-month study investigates qMRI re

Y Yu Song

Real-world evaluation of teplizumab in type 1 diabetes: Progression to insulin requirement

No abstractDiabetes Obes Metab. 2025 Dec 22. doi: 10.1111/dom.70354. Online ahead of print.NO ABSTRACTPMID:41424241 | DOI:10.1111/dom.70354

S Sahana Mahesh

Higher Cardiovascular Risk Factor Burden Associated With Cumulative Concussion History and Age-Related Differences

J Head Trauma Rehabil. 2025 Dec 22. doi: 10.1097/HTR.0000000000001140. Online ahead of print.ABSTRACTOBJECTIVE: Growing evidence suggests cardiovascular dysfunction represents 1 pathway by which recurrent concussion may lead to adverse long-term outcomes, with earlier onset increasing risk. We inves

B Benjamin L Brett

Nine-year follow-up of 24-hour movement behaviors and glucose metabolism status among adults from the Maastricht study

No abstractSci Rep. 2025 Dec 21. doi: 10.1038/s41598-025-33099-z. Online ahead of print.NO ABSTRACTPMID:41423484 | DOI:10.1038/s41598-025-33099-z

I Iris Willems

Acute and Chronic Management of Spontaneous Coronary Artery Dissection

Circ J. 2025 Dec 20. doi: 10.1253/circj.CJ-25-0966. Online ahead of print.ABSTRACTSpontaneous coronary artery dissection (SCAD) is an increasingly recognized, non-atherosclerotic cause of acute coronary syndrome (ACS), predominantly affecting younger women without traditional cardiovascular risk fac

K Ken Kato

Resting-State fMRI Reveals Cerebellar-Temporal Lobe Network Remodeling in Hyperlipidemia: A Graph Theoretical Analysis

Brain Res Bull. 2025 Dec 19:111697. doi: 10.1016/j.brainresbull.2025.111697. Online ahead of print.ABSTRACTHyperlipidemia (HLP) is a major risk factor for cardiovascular diseases and has a significant impact on the nervous system, potentially leading to cognitive decline. This study uses resting-sta

J Jian-Hui He

Transapical beating-heart approach is advantageous for surgical septal reduction therapy in pediatrics

J Thorac Cardiovasc Surg. 2025 Dec 19:S0022-5223(25)01069-4. doi: 10.1016/j.jtcvs.2025.12.014. Online ahead of print.ABSTRACTBACKGROUND: Surgical septal myectomy is the gold-standard therapeutic strategy for majority of patients with obstructive hypertrophic cardiomyopathy (oHCM). However, limited d

Y Yue Chen

Equine coronary sinus and great cardiac vein anatomy relevant to cardiac electrophysiology

J Vet Cardiol. 2025 Dec 2;64:1-13. doi: 10.1016/j.jvc.2025.11.006. Online ahead of print.ABSTRACTINTRODUCTION/OBJECTIVES: The coronary sinus (CS) and great cardiac vein (GCV) are crucial in cardiac electrophysiology and can be arrhythmogenic in humans. In horses, CS/GCV catheterisation is increasing

L L Ibrahim

Exercise in CKM syndrome progression: a stage-specific approach to cardiovascular, metabolic, and renal health

Cardiovasc Diabetol. 2025 Dec 20. doi: 10.1186/s12933-025-03029-4. Online ahead of print.ABSTRACTCardiovascular-Kidney-Metabolic (CKM) syndrome progresses through distinct stages, from early metabolic risk factors to advanced cardiovascular disease and kidney dysfunction. Across these stages, exerci

Z Zacharias Papadakis

Is there a compression of morbidity and does it vary across social strata among older European adults? A retrospective cohort study of two waves 15 years apart

Arch Gerontol Geriatr. 2025 Dec 11;142:106118. doi: 10.1016/j.archger.2025.106118. Online ahead of print.ABSTRACTBACKGROUND: Compression of morbidity may be linked to belonging to particular social strata defined by intersections of age, gender, migration and occupation. Extending the approach by Cr

E Enrique Alonso-Perez

Independent risk factors associated with a history of exercise associated muscle cramps (EAMC) among 21460 cycling race entrants (SAFER XXXVI): a descriptive cross-sectional study

Braz J Phys Ther. 2025 Dec 18;30(2):101559. doi: 10.1016/j.bjpt.2025.101559. Online ahead of print.ABSTRACTBACKGROUND: There is limited research on cyclists with a history of exercise associated muscle cramps (hEAMC) defined as muscle cramping (painful, spontaneous, sustained spasm of a muscle) duri

C Carey Pohl