J Biomed Mater Res B Appl Biomater. 2026 Jan;114(1):e70005. doi: 10.1002/jbmb.70005.
ABSTRACT
In this work, a green formulation of iron nanoparticles (FeNPs) using Lavandula angustifolia leaf extract was described. FeNPs were described using several spectroscopic approaches, and their efficacy in treating myocardial infarction was investigated. The nanoparticles were generated with a spherical shape. Isoproterenol was used to produce a myocardial infarction. Cardiac function was evaluated following treatment with FeNPs@L. angustifolia at various dosages using histochemical, biochemical, and electrocardiogram (ECG) studies. In vitro apoptosis and inflammatory responses in HCAECs were investigated. Real-time PCR was used to assess the activation of cytokines and PPAR-γ/NF-κB in response to lipopolysaccharide. In comparison to rats with myocardial infarction, FeNPs@L. angustifolia treatment greatly avoids typical ST-segment depression. Furthermore, FeNPs@L. angustifolia considerably reduces myocardial damage marker levels, lowers mortality rates, and improves ventricular wall infarction. Furthermore, in the heart of myocardial infarction mice, FeNPs@L. angustifolia decreased the proinflammatory cytokines. The normalization of phosphorylation gene expression may be linked to the positive effects of nanoparticles. FeNPs@L. angustifolia dramatically reduced the expression of inflammatory cytokines and cell death. Current data reports the cardioprotective effects of FeNPs@L. angustifolia on myocardial infarction caused by isoproterenol, which may be connected to the NF-κB signaling suppression and the PPAR-γ activation. In conclusion, the current study provides a modern remedial strategy for myocardial infarction treatment in a clinical context.
PMID:41424390 | DOI:10.1002/jbmb.70005