Int J Rheum Dis. 2026 May;29(5):e70683. doi: 10.1111/1756-185x.70683.ABSTRACTOBJECTIVES: Tofacitinib, the first approved oral small-molecule Janus kinase inhibitor (JAKi), is widely used for treating rheumatoid arthritis (RA). This study aims to compare the drug retention rates of tofacitinib betwee
Diabetol Metab Syndr. 2026 May 23. doi: 10.1186/s13098-026-02190-4. Online ahead of print.ABSTRACTBACKGROUND: Metabolic syndrome (MetS) is a key predictor of non-communicable diseases (NCDs) and mortality, causing public health challenge worldwide. This study aimed to estimate the incidence rates an
J Transl Med. 2026 May 23. doi: 10.1186/s12967-026-08303-x. Online ahead of print.ABSTRACTBACKGROUND: Advanced therapy medicinal products (ATMPs) comprise gene therapies, somatic cell therapies, tissue engineered products (TEPs), and combined ATMPs. These modalities have the potential to deliver dur
BMC Public Health. 2026 May 23. doi: 10.1186/s12889-026-27850-y. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular diseases are common in aging populations and are closely associated with multiple factors. However, the cumulative effects of green-space exposure and air pollutants on cardiovas
BMC Prim Care. 2026 May 23. doi: 10.1186/s12875-026-03392-5. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular diseases (CVDs) caused by diabetes pose a significant health burden. CVD risk communication refers to the process of conveying CVD risk information to the public or patients at the i
BMC Anesthesiol. 2026 May 23. doi: 10.1186/s12871-026-03936-3. Online ahead of print.ABSTRACTBACKGROUND: Minimally invasive cardiac surgery via minithoracotomy is associated with postoperative pain. Continuous BRILMA (block of the lateral branches of the intercostal nerves in the mid-axillary line)
Commun Med (Lond). 2026 May 23. doi: 10.1038/s43856-026-01678-4. Online ahead of print.ABSTRACTBACKGROUND: Mucosally-applied aminoglycosides have demonstrated host-directed antiviral activity in preclinical models through induction of interferon-stimulated genes (ISGs). However, it remains unknown i
Cardiovasc Interv Ther. 2026 May 23. doi: 10.1007/s12928-026-01291-1. Online ahead of print.ABSTRACTDrug-coated balloons (DCBs) are increasingly used in femoropopliteal (FP) endovascular therapy (EVT) to limit permanent scaffold implantation. Although this paradigm shift has substantially altered tr
Sci Rep. 2026 May 23. doi: 10.1038/s41598-026-54530-z. Online ahead of print.ABSTRACTVisceral fat accumulation is a key factor in the onset of cardiometabolic diseases, including hypertension. Metabolic Score for Visceral Fat (METS-VF) is an innovative, non-invasive metric developed to estimate visc
Sci Rep. 2026 May 23. doi: 10.1038/s41598-026-54591-0. Online ahead of print.ABSTRACTCarbapenem-resistant bacteria represent a significant challenge for patients with cancer; however, the characteristics and prognoses of carbapenem-resistant Gram-negative bacilli (CRGNB) infections in Japanese patie
Nat Commun. 2026 May 23;17(1):4607. doi: 10.1038/s41467-026-73230-w.ABSTRACTRBM20 is a cardiac splicing regulator whose dysfunction causes severe cardiomyopathies. Here, we uncover an unexpected layer of RBM20 regulation through a previously unrecognized transcription start site located between the
Cell Death Dis. 2026 May 23. doi: 10.1038/s41419-026-08882-z. Online ahead of print.ABSTRACTAging is a well-recognized risk factor in cardiovascular diseases (CVDs), primarily due to its association with the gradual decline in cardiac function. This decline significantly influences the pathogenesis
Cell Death Discov. 2026 May 23. doi: 10.1038/s41420-026-03147-2. Online ahead of print.ABSTRACTFerroptosis, a unique form of regulated cell death driven by iron-dependent lipid peroxidation, and macrophage polarization, which reflects the high plasticity of the immune system, represent two prominent
Nat Commun. 2026 May 23. doi: 10.1038/s41467-026-73545-8. Online ahead of print.ABSTRACTSpinal muscular atrophy (SMA) results from a deficiency of the survival motor neuron (SMN) protein. Zolgensma, an adeno-associated virus (AAV)-based SMN1 gene-replacement therapy, is approved for SMA, though its
J Clin Lipidol. 2026 Apr 9:S1933-2874(26)00105-4. doi: 10.1016/j.jacl.2026.04.006. Online ahead of print.ABSTRACTSevere hypertriglyceridemia in children is uncommon and typically results from a combination of acquired and genetic factors. We report the case of an 11-year-old boy with triglyceride le
Atherosclerosis. 2026 May 24:120729. doi: 10.1016/j.atherosclerosis.2026.120729. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Nucleotide-binding oligomerization domain-containing protein (NOD)1 is an intracellular pattern recognition receptor that initiates immune responses upon ligation of mo
Atherosclerosis. 2026 May 24:120745. doi: 10.1016/j.atherosclerosis.2026.120745. Online ahead of print.ABSTRACTApproximately 50 million people are living with dementia worldwide, a number projected to reach more than 150 million by 2050. Dementia has emerged as one of the most pressing public health
Atherosclerosis. 2026 May 24:120787. doi: 10.1016/j.atherosclerosis.2026.120787. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) is a leading cause of death, with substantial residual risk persisting despite current lipid-lowering, antithrombotic, antihypertensive, weigh
Atherosclerosis. 2026 May 24:120731. doi: 10.1016/j.atherosclerosis.2026.120731. Online ahead of print.ABSTRACTCalcific aortic valve stenosis (CAVS) is the most common valvular heart disease requiring intervention. Progressive fibrocalcific thickening of the valve leaflets results in left ventricula
No abstractAtherosclerosis. 2026 May 24:120687. doi: 10.1016/j.atherosclerosis.2026.120687. Online ahead of print.NO ABSTRACTPMID:42177116 | DOI:10.1016/j.atherosclerosis.2026.120687
Clin Plast Surg. 2026 Jul;53(3):371-380. doi: 10.1016/j.cps.2026.02.007. Epub 2026 Apr 1.ABSTRACTGustilo IIIC fractures represent the most severe spectrum of lower extremity trauma, characterized by high-energy skeletal injury, vascular disruption, and soft-tissue loss. Contemporary management deman
Methods Cell Biol. 2026;207:53-74. doi: 10.1016/bs.mcb.2026.01.018. Epub 2026 Feb 5.ABSTRACTChimeric Antigen Receptor T-cell (CAR-T) based immunotherapy represents a ground-breaking advancement in the treatment of certain haematological malignancies, such as acute lymphoblastic leukemia (ALL) and mu
Ann Vasc Surg. 2026 May 22:S0890-5096(26)00381-X. doi: 10.1016/j.avsg.2026.05.073. Online ahead of print.ABSTRACTOBJECTIVE: Infrapopliteal atherosclerosis and calcification are major causes of chronic limb ischemia. This study aimed to identify causative genes and immune cell phenotypes driving this
Vascul Pharmacol. 2026 May 22:107655. doi: 10.1016/j.vph.2026.107655. Online ahead of print.ABSTRACTIn response to pathological stimuli, VSMCs modulate from a quiescent, contractile phenotype to a synthetic, non-contractile phenotype with increased migration, proliferation, and expression of matrix
