Molecular mechanisms of shenhong tongluo formula against myocardial ischemia-reperfusion injury: Insights from RNA sequencing, bioinformatics, reverse network pharmacology, molecular docking, and molecular dynamics simulations combined with experimental studies

Phytomedicine. 2026 Jan 29;155:157896. doi: 10.1016/j.phymed.2026.157896. Online ahead of print.ABSTRACTBACKGROUND: Myocardial ischemia/reperfusion injury (MIRI) remains a significant challenge in the field of cardiovascular treatment. Ferroptosis is a key driver in the pathogenesis of MIRI. Shenhon

R Rong He

Association Between Depressive Symptoms and Incidence of Stroke in a Population With Cardiovascular-Kidney-Metabolic Syndrome Stages 0 to 3: Nationwide Prospective Cohort Study

Interact J Med Res. 2026 Apr 1;15:e80988. doi: 10.2196/80988.ABSTRACTBACKGROUND: The association between depressive symptoms and cardiovascular diseases is well established. However, their impact on the incidence of stroke in individuals with cardiovascular-kidney-metabolic (CKM) syndrome remains un

Y Yunjie Li

Projected Health and Economic Benefits of Air Quality Targets in China: Modeling Study

JMIR Public Health Surveill. 2026 Apr 1;12:e84809. doi: 10.2196/84809.ABSTRACTBACKGROUND: Air pollution continues to impose a substantial health and economic burden in China. Despite recent improvements, national annual average PM2.5 (fine particulate matter) concentrations remain substantially abov

S Siyuan Wang

Contribution of hepatic steatosis to subclinical atherosclerosis progression in people with HIV receiving integrase inhibitors: A 5-Year prospective cohort study

AIDS. 2026 Mar 31. doi: 10.1097/QAD.0000000000004512. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVES: Cardiovascular disease (CVD) remains elevated among people with HIV (PWH) despite virological suppression. Whether metabolic-hepatic abnormalities contribute to vascular remodeling during c

J Javier García-Abellán

HIV-1 gp120 exposure associates with mitochondrial and PKM remodeling in cardiomyocytes

AIDS. 2026 Mar 31. doi: 10.1097/QAD.0000000000004507. Online ahead of print.ABSTRACTOBJECTIVE: To determine whether HIV-1 gp120 impairs cardiomyocyte bioenergetics.DESIGN/METHODS: We exposed neonatal rat ventricular myocytes to gp120 and measured mitochondrial respiration, gene expression, and metab

M Maryline Santerre

Transthyretin V122I Variant and Protein Affects Cardiac Severity and Mortality in Sickle Cell Disease

Blood Adv. 2026 Apr 1:bloodadvances.2026019698. doi: 10.1182/bloodadvances.2026019698. Online ahead of print.ABSTRACTThe amyloidogenic V122I variant of the transthyretin (TTR) gene is found in about 3% of African-Americans and increases cardiovascular mortality risk after age 65 years. Sickle cell d

H Haiou Li

Clinical features of Italian adult individuals with X-linked hypophosphatemia: a multicenter retrospective study

Endocr Connect. 2026 Apr 1:EC-25-0756. doi: 10.1530/EC-25-0756. Online ahead of print.ABSTRACTOBJECTIVE: X-linked hypophosphatemia (XLH) is the most common congenital phosphate disorder affecting individuals throughout the lifespan. We investigated the skeletal burden, the cardiovascular involvement

S Silvia Carrara

Chronic kidney disease stage 4 and 5: comparison of therapeutic projects before kidney replacement therapy between men and women in Brittany

J Nephrol. 2026 Apr 1:aajaf001. doi: 10.1093/joneph/aajaf001. Online ahead of print.ABSTRACTBACKGROUND: In patients with stage 4 and 5 chronic kidney disease (CKD), the reduction of kidney function prompts decisions regarding kidney replacement therapy (KRT): dialysis, transplantation or an alternat

P Pierre Gary-Bobo

Optimizing physical activity bouts to interrupt sedentary behaviour for cardiometabolic health: a systematic review and meta-analyses of randomized controlled trials

Eur J Prev Cardiol. 2026 Apr 1:zwag079. doi: 10.1093/eurjpc/zwag079. Online ahead of print.ABSTRACTAIMS: Chronic diseases such as type 2 diabetes mellitus and cardiovascular diseases are leading causes of mortality worldwide, with sedentary behaviour (SB) and physical inactivity recognized as major

J Jen Vanherle

Facility-level integration of hypertension and diabetes services with HIV treatment in sub-Saharan Africa: Observational evidence from Malawi, South Africa, and Zambia

PLoS One. 2026 Apr 1;21(4):e0346029. doi: 10.1371/journal.pone.0346029. eCollection 2026.ABSTRACTBACKGROUND: A growing number of people living with HIV (PLHIV) also have non-communicable diseases (NCDs). Shifting to an integrated delivery model may facilitate care-seeking and improve outcomes for pe

L Linda Sande

Association between socioeconomic status and cardiovascular disease by sex: Mediating roles of psychological and behavioral factors

PLoS One. 2026 Apr 1;21(4):e0345573. doi: 10.1371/journal.pone.0345573. eCollection 2026.ABSTRACTPrevious research shows that low socioeconomic status (SES) increases the risk of cardiovascular disease (CVD) and contributes to health disparities through the unequal distribution of intermediary facto

J Jiwon Choi

Association between Ambient Temperature and Ventricular Arrhythmias in Patients with Implantable Cardioverter-Defibrillators: A Time-Stratified Case-Crossover Study in China

Environ Sci Technol. 2026 Apr 1. doi: 10.1021/acs.est.5c14540. Online ahead of print.ABSTRACTAmbient temperature has been recognized as an environmental trigger for adverse cardiovascular events. However, its association with ventricular arrhythmias (VAs) in patients with implantable cardioverter-de

X Xiaoyao Li

Desialylated low-density lipoprotein: A stronger predictor of coronary atherosclerosis burden than low-density lipoprotein cholesterol

Ann Acad Med Singap. 2026 Mar 18;55(3):118-127. doi: 10.47102/annals-acadmedsg.2025343.ABSTRACTINTRODUCTION: This study aimed to investigate the relationship between plasma desialylated low-density lipoprotein (desLDL) levels and the severity of coronary artery disease (CAD), and to evaluate the pot

Q Qin Liu

The Role of Inspiratory Muscle Strength in Functional Capacity and Left Atrial Strain in Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction

Clin Cardiol. 2026 Apr;49(4):e70261. doi: 10.1002/clc.70261.ABSTRACTOBJECTIVES: This study aimed to explore the correlation among inspiratory muscle strength, left atrial strain reservoir (LAsr), and functional capacity in patients with heart failure with preserved and mildly reduced ejection fracti

H Huu Dat Tran

Protocol for the isolation, culturing, and evaluation of primary Muller glial cells from pig retina as cellular models in health and disease

STAR Protoc. 2026 Mar 31;7(2):104483. doi: 10.1016/j.xpro.2026.104483. Online ahead of print.ABSTRACTMüller glial cells maintain retinal homeostasis and provide structural and metabolic support. The pig eye closely resembles the human eye in morphology and physiology, offering strong translational p

Y Yesim Tütüncü

Echocardiographic Evaluation of Global Cardiac Function in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: An Integrated Review of Parameters and Techniques

Echocardiography. 2026 Apr;43(4):e70442. doi: 10.1111/echo.70442.ABSTRACTSystemic sclerosis (SSc) is a connective tissue disease frequently complicated by pulmonary arterial hypertension (PAH), a leading cause of morbidity and mortality. Global cardiac function is a key determinant of prognosis and

Z Zitong Zhang

Dementia in Severe Schizophrenia

JAMA Psychiatry. 2026 Apr 1. doi: 10.1001/jamapsychiatry.2026.0171. Online ahead of print.ABSTRACTIMPORTANCE: Dementia develops in individuals with schizophrenia 4- to 20-fold more frequently than in the general population, but its etiology remains unexplained.OBJECTIVE: To characterize the cognitiv

U Ujval S Pathak

Statin Eligibility According to Atherosclerotic Cardiovascular Disease Risk in the US

No abstractJAMA Cardiol. 2026 Apr 1. doi: 10.1001/jamacardio.2026.0409. Online ahead of print.NO ABSTRACTPMID:41920563 | DOI:10.1001/jamacardio.2026.0409

R Robert C Kaplan

Time to Quadruple Therapy After Initial Diagnosis of Heart Failure With Reduced Ejection Fraction

JAMA Cardiol. 2026 Apr 1. doi: 10.1001/jamacardio.2026.0375. Online ahead of print.ABSTRACTIMPORTANCE: Timely prescription of quadruple guideline-directed medical therapies (GDMTs) for patients with heart failure with reduced ejection fraction (HFrEF) is associated with improved morbidity and mortal

J Joshua A Jacobs

Cardiovascular Disease Risk of Left-Sided Breast Radiotherapy

No abstractJAMA Netw Open. 2026 Apr 1;9(4):e264111. doi: 10.1001/jamanetworkopen.2026.4111.NO ABSTRACTPMID:41920549 | DOI:10.1001/jamanetworkopen.2026.4111

A Avirup Guha

Long-Term Risk of Cardiovascular Disease After Contemporary Left-Sided Breast Radiation Therapy

JAMA Netw Open. 2026 Apr 1;9(4):e264098. doi: 10.1001/jamanetworkopen.2026.4098.ABSTRACTIMPORTANCE: External beam radiation therapy (EBRT) for left-sided breast cancer historically increased the risk of cardiovascular disease (CVD). Advances in EBRT have reduced mean heart dose, but contemporary pop

E Erika Nakajima

Acute Myocardial Infarction in Medicare Beneficiaries During and After the COVID-19 Pandemic

JAMA Netw Open. 2026 Apr 1;9(4):e264122. doi: 10.1001/jamanetworkopen.2026.4122.ABSTRACTIMPORTANCE: During early months of the COVID-19 pandemic, presentations for acute myocardial infarction (AMI) declined significantly, and outcomes worsened. However, the full extent and long-term sequelae of chan

J Jonah M Graves

Sex Differences in Self-Rated Health and Cardiovascular Disease Events

JAMA Netw Open. 2026 Apr 1;9(4):e264129. doi: 10.1001/jamanetworkopen.2026.4129.ABSTRACTIMPORTANCE: Clinical risk factors, lifestyle factors, and social determinants of health have established sex-specific associations with new-onset cardiovascular disease (CVD). However, little is known about the r

M Maneesh Sud

Blood Pressure Genetic Risk and Incident Hypertension at 2 to 7 Years Post Partum

JAMA Cardiol. 2026 Apr 1. doi: 10.1001/jamacardio.2026.0363. Online ahead of print.ABSTRACTIMPORTANCE: Hypertensive disorders of pregnancy (HDP; ie, preeclampsia/eclampsia and gestational hypertension) are associated with earlier development of chronic hypertension. Whether genetic risk for high sys

J Jan Hemeryck