Neurology. 2026 Jul 14;107(1):e218198. doi: 10.1212/WNL.0000000000218198. Epub 2026 Jun 18.ABSTRACTBACKGROUND AND OBJECTIVES: Atrial fibrillation (AF)-associated ischemic stroke is often managed as a single clinical entity; however, prognosis may vary depending on whether AF was detected after the s
Neurology. 2026 Jul 14;107(1):e218149. doi: 10.1212/WNL.0000000000218149. Epub 2026 Jun 18.ABSTRACTBACKGROUND AND OBJECTIVES: Neurologic outcomes after pediatric large vessel occlusion (LVO) stroke are poor. In the absence of a pediatric randomized clinical trial, cohort and registry studies have de
Neurology. 2026 Jul 14;107(1):e218179. doi: 10.1212/WNL.0000000000218179. Epub 2026 Jun 18.ABSTRACTBACKGROUND AND OBJECTIVES: Recent randomized trials reported no overall functional benefit of endovascular treatment (EVT) for distal medium-vessel occlusion (DMVO) and did not identify consistent effe
Proc Natl Acad Sci U S A. 2026 Jun 23;123(25):e2426990123. doi: 10.1073/pnas.2426990123. Epub 2026 Jun 18.ABSTRACTDeterioration of the blood-brain barrier (BBB), including impaired neurovascular uncoupling, contributes to cognitive decline in aging. The BBB is formed principally by brain microvascul
Circ Res. 2026 Jun 19;139(1):e327266. doi: 10.1161/CIRCRESAHA.125.327266. Epub 2026 Jun 18.ABSTRACTPC1 (polycystin-1), traditionally viewed through the lens of renal pathophysiology in autosomal dominant polycystic kidney disease, has emerged as a central regulator of cardiovascular mechanobiology.
Circ Res. 2026 Jun 19;139(1):e328563. doi: 10.1161/CIRCRESAHA.126.328563. Epub 2026 Jun 18.ABSTRACTCardiovascular-kidney-metabolic syndrome is driven by inflammatory mechanisms that propagate injury across organ boundaries, yet the molecular mediators converting systemic inflammation into end-organ
PLoS One. 2026 Jun 18;21(6):e0351946. doi: 10.1371/journal.pone.0351946. eCollection 2026.ABSTRACTBACKGROUND: Cardiovascular-Kidney-Metabolic (CKM) syndrome involves disordered mineralization processes. Herein, we investigated the serum alkaline phosphatase (ALP), calcium, and phosphorus across CKM
Arkh Patol. 2026;88(3):39-46. doi: 10.17116/patol20268803139.ABSTRACTArterial hypertension is a socially significant disease, one of whose complications is cerebral ischemia. Various mechanisms are involved in the adaptation of neurons to hypoxia, including those modulating mitochondrial activity, t
JMIR Diabetes. 2026 Jun 18;11:e83059. doi: 10.2196/83059.ABSTRACTBACKGROUND: Digital twin (DT) systems have emerged as a promising approach in health care, enabling real-time, patient-specific virtual modeling and personalized interventions. In diabetes care, DTs offer the potential to revolutionize
Acad Emerg Med. 2026 Jun;33(6):e70360. doi: 10.1111/acem.70360.ABSTRACTBACKGROUND: Although guidelines support outpatient management for low-risk pulmonary embolism, U.S. emergency department (ED) adoption remains low, partly due to limited contemporary evidence. Direct oral anticoagulant (DOAC) era
PLOS Glob Public Health. 2026 Jun 18;6(6):e0006641. doi: 10.1371/journal.pgph.0006641. eCollection 2026.ABSTRACTIschemic heart disease (IHD) is the leading cause of death in the United States, but the long-term impact of ambient temperature on IHD mortality remains poorly characterized. Existing res
Pediatr Pulmonol. 2026 Jun;61(6):e71705. doi: 10.1002/ppul.71705.ABSTRACTINTRODUCTION: Primary ciliary dyskinesia (PCD) is a genetic disorder characterized by impaired mucociliary clearance, leading to recurrent airway infections and bronchiectasis. Monitoring disease progression requires both funct
Cardiorenal Med. 2026 Jun 18:1-24. doi: 10.1159/000553163. Online ahead of print.ABSTRACTIntroduction Chronic kidney disease (CKD) frequently coexists with cardiovascular disease, diabetes and obesity through shared biological pathways encompassed within the American Heart Association cardiovascular
Radiographics. 2026 Jul;46(7):e250175. doi: 10.1148/rg.250175.ABSTRACTDiagnosis of erectile dysfunction (ED) is increasing due to the prevalence of cardiovascular disease, diabetes, lifestyle changes, and an aging population. The worldwide prevalence of ED in 2025 was projected to be 322 million men
J Biomed Mater Res B Appl Biomater. 2026 Jun;114(6):e70114. doi: 10.1002/jbm.b.70114.ABSTRACTCardiovascular diseases affect a large portion of the global population and remain leading causes of morbidity and mortality. Endovascular stenting, a minimally invasive procedure, enables the insertion and
Cas Lek Cesk. 2026;165(2):55-60.ABSTRACTColorectal cancer (CRC) is one of the most common malignant diseases worldwide. Its etiology and prognosis are significantly influenced by numerous comorbidities that may affect both the risk of tumor development and the course of the disease, including treatm
Future Cardiol. 2026 Jun 18:1-10. doi: 10.1080/14796678.2026.2689421. Online ahead of print.ABSTRACTAIMS: To characterize lesion distribution, procedural strategy, and short-term outcomes after endovascular revascularisation for symptomatic lower-extremity peripheral arterial disease (PAD) in routin
The 5-HT(2B)R, a member of the G protein-coupled receptor (GPCR) family, has been implicated in various diseases, including cardiovascular conditions, fibrotic disorders, cancer, and neuropsychiatric illnesses. Despite its therapeutic potential, the 5-HT(2B)R remains largely underexplored due to the
J Clin Hypertens (Greenwich). 2026 Jun;28(6):e70318. doi: 10.1111/jch.70318.ABSTRACTUncontrolled hypertension is a leading cause of preventable cardiovascular mortality. Although self-measured blood pressure (SMBP) monitoring is recommended by evidence-based guidelines, adoption remains uneven in sa
JCI Insight. 2026 Jun 18:e200684. doi: 10.1172/jci.insight.200684. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a progressive vascular syndrome characterized by aberrant signaling, severe pulmonary artery remodeling, and right ventricular (RV) failure, a major driver of mor
Curr Atheroscler Rep. 2026 Jun 18;28(1):64. doi: 10.1007/s11883-026-01432-0.ABSTRACTPURPOSE OF REVIEW: This review highlights recent advances in single-cell analysis technologies and their application in clarifying the cellular and molecular complexity of atherosclerosis, redefining our understandin
Curr Diab Rep. 2026 Jun 18;26(1):18. doi: 10.1007/s11892-026-01627-4.ABSTRACTPURPOSE OF REVIEW: Adults with inflammatory bowel disease (IBD) demonstrate a high prevalence of obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiometabolic comorbidities. Cardiovascular di
Intern Emerg Med. 2026 Jun 18. doi: 10.1007/s11739-026-04438-3. Online ahead of print.ABSTRACTType 2 diabetes mellitus and obesity constitute major global public health concerns, with their incidence continuing to rise worldwide. These metabolic conditions are closely interrelated and commonly coexi
Fam Cancer. 2026 Jun 18;25(3):65. doi: 10.1007/s10689-026-00579-8.ABSTRACTVon Hippel-Lindau (VHL) disease is a hereditary tumor predisposition syndrome caused by pathogenic germline variants in the VHL gene. Patients with VHL disease have an increased risk of developing characteristic VHL disease-as
