Cardiovascular-Kidney-Metabolic Syndrome in Autosomal Dominant Polycystic Kidney Disease
No abstractJ Am Soc Nephrol. 2026 Sep 25. doi: 10.1681/ASN.0000001291. Online ahead of print.NO ABSTRACTPMID:42789922 | DOI:10.1681/ASN.0000001291
Resolution of Phlegmasia Cerulea Dolens in a Patient with Metastatic Cancer and an Inferior Vena Cava Filter
R I Med J (2013). 2026 Oct 1;109(10):15-17.ABSTRACTPhlegmasia cerulea dolens (PCD) is a rare but serious complication of extensive venous thromboembolism (VTE) that can lead to limb ischemia and significant morbidity if not treated promptly. We describe a 69-year-old man with metastatic non-small ce
Association between fatigue and self-care in patients with heart failure: a cross-sectional study
Rev Esc Enferm USP. 2026 Sep 25;60:e20250493. doi: 10.1590/1980-220X-REEUSP-2025-0493en. eCollection 2026.ABSTRACTOBJECTIVE: To analyze the association between fatigue, self-care, and sociodemographic and clinical variables in patients with heart failure.METHOD: A cross-sectional and correlational s
Alcohol use disorder and cardiovascular risk in type 2 diabetes: beyond alcohol consumption
Eur J Prev Cardiol. 2026 Sep 25:zwag455. doi: 10.1093/eurjpc/zwag455. Online ahead of print.ABSTRACTAIMS: Alcohol use disorder (AUD) is a chronic neuropsychiatric condition associated with clustering cardiovascular risk factors, yet its independent contribution to incident cardiovascular disease in
A Transition of Care Service to Reduce Hospital Readmissions for High-Risk Cardiology Patients (RECARD): Protocol for a Pre-Post Interventional Trial
JMIR Res Protoc. 2026 Sep 25;15:e94841. doi: 10.2196/94841.ABSTRACTBACKGROUND: Transition of care (TOC) is a high-risk period for medication errors as patients move between multiple health care professionals, settings, and changing medication regimens. Ineffective communication systems further incre
TRAF7 mutations stabilize K/NRAS and hyperactivate MAPK signaling to cause CAFDADD neurodevelopmental defects
Sci Adv. 2026 Sep 25;12(39):eadw8672. doi: 10.1126/sciadv.adw8672. Epub 2026 Sep 25.ABSTRACTThe MAPK-ERK1/2 pathway plays a crucial role in neurodevelopment during embryogenesis, and the hyperactivation of this signaling cascade serves as a pathological hallmark for various neurodevelopmental disord
Multimodal profiling of atherosclerosis: Protocol and pilot data for the AtherOMICS biobank
Sci Adv. 2026 Sep 25;12(39):eaee2639. doi: 10.1126/sciadv.aee2639. Epub 2026 Sep 25.ABSTRACTOmics technologies enable deep profiling of human atherosclerosis but have mostly been applied in small studies lacking integration with other data modalities. AtherOMICS is a biobanking project linking multi
mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation
Sci Adv. 2026 Sep 25;12(39):eaee1905. doi: 10.1126/sciadv.aee1905. Epub 2026 Sep 25.ABSTRACTThe mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal cues to regulate hepatic lipid metabolism with major implications for metabolic dysfunction-associated steatotic liver d
Top 20 Research Studies of 2025 for Primary Care Physicians
Am Fam Physician. 2026 Aug;114(2):175-183.ABSTRACTThis article summarizes the top 20 research studies of 2025 identified as POEMs (patient-oriented evidence that matters). Treating male sex partners of female patients with oral and topical medication reduces recurrence of bacterial vaginosis. Anti-i
Aortic Stenosis: Diagnosis and Treatment
Am Fam Physician. 2026 Aug;114(2):148-155.ABSTRACTAortic stenosis is the most common valvular heart disease in the United States, and it affects up to 3.7% of the general population. Atherosclerosis results in progressive calcification of the aortic valve, leading to valve narrowing. Aortic stenosis
Age at dementia diagnosis, subtype associations, and neuroimaging differentiation in Bangladesh: The CARED study
PLoS One. 2026 Sep 25;21(9):e0359109. doi: 10.1371/journal.pone.0359109. eCollection 2026.ABSTRACTBACKGROUND: Evidence on age at diagnosis of dementia and differentiation of dementia subtypes in Bangladesh is limited. This study aimed to determine age at diagnosis, examine factors associated with de
Identification and mechanistic investigation of novel biomarkers for diabetic retinopathy through hypoxia- and cuproptosis-associated gene analysis
PLoS One. 2026 Sep 25;21(9):e0358182. doi: 10.1371/journal.pone.0358182. eCollection 2026.ABSTRACTBACKGROUND: Emerging evidence indicates that hypoxia- and cuproptosis-related molecular alterations may contribute to diabetic retinopathy (DR). This study aimed to identify biomarkers associated with t
Surface micro-patterned drug-coated balloon enhances early biological efficacy in a porcine coronary in-stent restenosis model
PLoS One. 2026 Sep 25;21(9):e0359232. doi: 10.1371/journal.pone.0359232. eCollection 2026.ABSTRACTBACKGROUND: Drug-coated balloon (DCB) therapy for in-stent restenosis (ISR) relies on efficient drug transfer during balloon-artery contact. Surface micro-patterning has been proposed to enhance transfe
Stakeholder perceptions of the acceptability of an intervention to improve uptake of evidence-based emergency myocardial infarction care in Tanzania: A qualitative study
PLoS One. 2026 Sep 25;21(9):e0357564. doi: 10.1371/journal.pone.0357564. eCollection 2026.ABSTRACTBACKGROUND: Acute myocardial infarction (AMI) is an increasing cause of morbidity and mortality in Sub-Saharan Africa (SSA) but is often underdiagnosed and undertreated. To address this gap, the Multico
Longitudinal proteomic organ-specific aging in heart failure
Eur J Heart Fail. 2026 Sep 25:xuag298. doi: 10.1093/ejhf/xuag298. Online ahead of print.ABSTRACTBACKGROUND: Heart failure (HF) is a systemic syndrome affecting multiple organs. Organ age gaps (OAGs), quantifying organ-level aging from plasma proteomics, are linked to organ-specific disease including
Ratio of red blood cell distribution width to albumin level and mortality outcomes in population with chronic kidney disease
Kidney Blood Press Res. 2026 Sep 25:1. doi: 10.1159/kbr/adjag012. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) is one of the major public health issues worldwide. The red blood cell distribution width to albumin ratio (RAR) has emerged as a reliable and accessible marker to
Effects of denosumab or romosozumab on vascular calcification in dialysis patients: a systematic review and meta-analysis
Kidney Blood Press Res. 2026 Sep 25:1. doi: 10.1159/kbr/adjag010. Online ahead of print.ABSTRACTINTRODUCTION: Patients on hemodialysis are at high risk of vascular calcification, which contributes to cardiovascular events and mortality. The impact of osteoporosis therapies, including denosumab and r
Protocol for quantitative image analysis of alizarin red staining to assess osteogenesis in cultured cells
STAR Protoc. 2026 Sep 25;7(4):104860. doi: 10.1016/j.xpro.2026.104860. Online ahead of print.ABSTRACTEndothelial-to-mesenchymal transition (EndMT) generates mesenchymal-like cells with multilineage differentiation potential. We describe steps for inducing EndMT in human venous endothelial cells, dir
Current Status and Associated Factors of Technophobia Toward Digital Health Technologies Among Older Patients With Stroke: Mixed Methods Study
J Med Internet Res. 2026 Sep 25;28:e95921. doi: 10.2196/95921.ABSTRACTBACKGROUND: Digital health technologies increasingly support long-term stroke management and rehabilitation, but technophobia may hinder their acceptance and sustained use among older patients with stroke. Evidence in this populat
Effectiveness of a Structured Robot-Assisted Ankle-Foot Sensorimotor Training Program Versus Manual Training in Chronic Stroke: Protocol for an Assessor-Blinded, Parallel-Group Randomized Controlled Trial
JMIR Res Protoc. 2026 Sep 25;15:e104766. doi: 10.2196/104766.ABSTRACTBACKGROUND: Stroke is a leading cause of long-term disability worldwide. Persistent lower-extremity motor and somatosensory impairments after stroke commonly limit walking and balance despite rehabilitation. Virtual reality (VR)-in
Brain-Kidney Axis Dysfunction in Intracerebral Hemorrhage: Mechanisms and Interventions
FASEB J. 2026 Oct 15;40(19):e72337. doi: 10.1096/fj.202601498RRR.ABSTRACTIntracerebral hemorrhage (ICH), the most fatal stroke subtype, causes severe acute brain injury and frequent multiple-organ dysfunction, with renal impairment representing a common and severe complication. ICH patients are susc
Cardiometabolic Disease Education and Health Services Among Public High Schools
JAMA Netw Open. 2026 Sep 1;9(9):e2636060. doi: 10.1001/jamanetworkopen.2026.36060.ABSTRACTIMPORTANCE: There is a paucity of research on school-based health education and services for cardiometabolic conditions, particularly at the national level.OBJECTIVE: To describe the health education and health
Cervical aortic arch with severe left ventricular dysfunction in a neonate: successful repair using whole-body perfusion
Multimed Man Cardiothorac Surg. 2026 Sep 25;2026. doi: 10.1510/mmcts.2026.038.ABSTRACTThe cervical aortic arch, first described by Reid, is a rare congenital anomaly of the aortic arch. We report the surgical management of a neonate with a right cervical arch with coarctation, a contralateral descen
Treatment of hypoplastic aortic arch with Stanford type B aortic dissection using "double arch" technique with thoracic endovascular aortic repair
No abstractSci China Life Sci. 2026 Sep 22. doi: 10.1007/s11427-026-3510-y. Online ahead of print.NO ABSTRACTPMID:42789220 | DOI:10.1007/s11427-026-3510-y