Effect of adequate daily water intake versus inadequate water intake on the risk of major chronic diseases in healthy adults: a systematic review protocol

Syst Rev. 2026 Mar 4. doi: 10.1186/s13643-026-03108-x. Online ahead of print.ABSTRACTBACKGROUND: Chronic diseases (cardiovascular, cancer, respiratory, diabetes and chronic kidney disease) account for over 80% of global mortality and remain a leading public health challenge. Although water intake is

L Lavra Nanayakkara

The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations

BMC Med. 2026 Mar 4. doi: 10.1186/s12916-026-04754-7. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular-kidney-metabolic (CKM) disease and chronic obstructive pulmonary disease (COPD) are associated with major adverse cardiovascular events (MACE). Whether COPD further increases MACE risk with

A Anne E Ioannides

Ethnic differences in the burden of cardiovascular disease risk factors among adult residents of London: the TOGETHER study

BMC Med. 2026 Mar 3. doi: 10.1186/s12916-026-04739-6. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular disease (CVD) remains the leading cause of premature death in England, with ethnic minority populations disproportionately affected, largely due to differences in socioeconomic factors, exp

F Fotios Barkas

Association between gestational diabetes mellitus and long-term all-cause and cause-specific mortality risks: a prospective cohort study based on metabolomics

No abstractDiabetol Metab Syndr. 2026 Mar 3. doi: 10.1186/s13098-026-02141-z. Online ahead of print.NO ABSTRACTPMID:41776572 | DOI:10.1186/s13098-026-02141-z

Y Yuyu Chen

Prognostic stratification of cardiovascular risk and cardiac remodeling in prediabetes: a multimodal analysis comparing ADA and WHO/IEC diagnostic criteria

Cardiovasc Diabetol. 2026 Mar 3. doi: 10.1186/s12933-026-03123-1. Online ahead of print.ABSTRACTBACKGROUND: Prediabetes, an intermediate metabolic state preceding diabetes, independently accelerates cardiovascular pathology through dysglycemia-driven mechanisms. This study evaluates the heterogeneou

Z Zhihao Zheng

Cardiovascular outcomes of intensive blood pressure control in patients with and without metabolic dysfunction-associated fatty liver disease: post hoc analysis of the CRHCP trial

BMC Med. 2026 Mar 4. doi: 10.1186/s12916-026-04678-2. Online ahead of print.ABSTRACTBACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) is an emerging cardiovascular risk factor; evidence-based blood pressure (BP) management strategies for this population remain limited. We aime

S Songyue Liu

Vericiguat for endothelial dysfunction and CRT response in non-responders: the VERCET prospective observational study

BMC Med. 2026 Mar 3. doi: 10.1186/s12916-026-04747-6. Online ahead of print.ABSTRACTBACKGROUND: Endothelial dysfunction (ED) is a negative prognostic factor for patients with heart failure (HF) who are treated with cardiac resynchronization therapy (CRT). ED could lead to CRT non-responders by incre

C Celestino Sardu

Differential Diagnosis between Sintilimab-related Autoimmune Myocarditis and Acute Myocardial Infarction

Biol Proced Online. 2026 Mar 3. doi: 10.1186/s12575-025-00267-4. Online ahead of print.ABSTRACTOBJECTIVE: To analyze the regularities and clinical features of sintilimab-related autoimmune myocarditis, and to summarize the differential diagnosis key points between sintilimab-related autoimmune myoca

Y Yihe Wu

BAG3 concentrations and heart failure events among individuals undergoing coronary and peripheral angiography

NPJ Cardiovasc Health. 2025 Oct 30;2(1):54. doi: 10.1038/s44325-025-00092-4.ABSTRACTTo investigate the circulating BAG3 role as a biomarker across Universal Definition of Heart Failure (UDHF) stages, plasma samples from 1121 individuals undergoing coronary and/or peripheral angiography across UDHF s

M Margot De Marco

Family history of premature CHD and risk factor control in patients with a recent ACS

NPJ Cardiovasc Health. 2025 Jul 15;2(1):37. doi: 10.1038/s44325-025-00060-y.ABSTRACTIndividuals with a family history of premature coronary heart disease (CHD) have increased cardiac morbidity and mortality, which may motivate them to modify their health behaviours. This analysis examines whether pa

D Daniel Yu-Hung Jeng

Characterizing lipoprotein profiles in coronary atherosclerosis development through quantitative lipidomics and proteomics approaches

NPJ Cardiovasc Health. 2025 Oct 30;2(1):55. doi: 10.1038/s44325-025-00091-5.ABSTRACTLipoproteins, synthesized in the liver and secreted into the bloodstream, play a central role in lipid transport. Although their quality affects cardiovascular outcomes, conventional markers do not fully explain the

H Hiroaki Takeda

Phenotyping valvular heart diseases using the lens of unsupervised machine learning: a scoping review

NPJ Cardiovasc Health. 2025 Sep 3;2(1):45. doi: 10.1038/s44325-025-00077-3.ABSTRACTAs the population ages, the incidence and mortality of valvular heart disease (VHD) are rising. Current diagnostic approaches depend on expert heuristics, which may miss complex phenotypes. Unsupervised machine learni

M Max Rosen

Can AI help with the hardest thing: pro health behavior change

NPJ Cardiovasc Health. 2026 Feb 2;3(1):3. doi: 10.1038/s44325-025-00101-6.ABSTRACTDespite cardiovascular disease risk reduction with intensive lifestyle modification, durable healthy behavior change remains elusive. An evidence-based framework for optimizing artificial intelligence (AI) augmented pr

D D Douglas Miller

Contemporary applications of artificial intelligence and machine learning in echocardiography

NPJ Cardiovasc Health. 2025 Jun 26;2(1):30. doi: 10.1038/s44325-025-00064-8.ABSTRACTArtificial intelligence (AI) and machine learning (ML) are reshaping echocardiography by automating image analysis, reducing variability, and enhancing diagnostic accuracy through tasks such as view classification, i

N Nastaran Raissi-Dehkordi

Synergistic elastase and papain injury drives abdominal aortic aneurysm formation and rupture in mice

Commun Med (Lond). 2026 Mar 3. doi: 10.1038/s43856-026-01485-x. Online ahead of print.ABSTRACTBACKGROUND: Abdominal aortic aneurysm (AAA) rupture leads to high morbidity and mortality. Current rodent models struggle to reliably mimic infrarenal AAA rupture. Chemical treatments using pancreatic elast

S Santiago Elizondo-Benedetto

Validation of AI-enhanced ECG image analysis for identifying extreme cardiac magnetic resonance metrics in a cross-ethnic UK biobank study

Sci Rep. 2026 Mar 4. doi: 10.1038/s41598-026-41824-5. Online ahead of print.ABSTRACTArtificial intelligence enhanced electrocardiography (AI-ECG) has shown promise in detecting cardiac abnormalities, but validation against cardiac magnetic resonance (CMR), the reference standard for cardiac structur

Y Yerin Kim

A contemporary review on heart failure with improved ejection fraction

NPJ Cardiovasc Health. 2025 Nov 24;2(1):56. doi: 10.1038/s44325-025-00093-3.ABSTRACTHeart failure is a complex condition caused by various etiologies that reduce cardiac output or increase cardiac pressures. It is classified by left ventricular ejection fraction, a key prognostic factor. New therapi

A Allison Weiss

Addressing myocardial infarction in South-Asian populations: risk factors and machine learning approaches

NPJ Cardiovasc Health. 2025 Feb 3;2(1):4. doi: 10.1038/s44325-024-00040-8.ABSTRACTCardiovascular diseases, especially myocardial infarction (MI), are an important and up-trending public health challenge in the South Asian population. With urbanization and economic development, there has been a rise

R Rick Rejeleene

Discordance in gender role attitudes between spouses and its relationship with the risk biomarkers of cardiovascular diseases: a couple-level analysis

No abstractSci Rep. 2026 Mar 3. doi: 10.1038/s41598-026-41697-8. Online ahead of print.NO ABSTRACTPMID:41776249 | DOI:10.1038/s41598-026-41697-8

K Kiho Sung

The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation

Diabetologia. 2026 Mar 4. doi: 10.1007/s00125-026-06688-4. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Growing evidence implicates gut microbiota-derived metabolites in metabolic homeostasis. Indole, a microbial tryptophan metabolite, has been reported to enhance glucagon-like peptide-1 (GLP-1) s

P Phyllis Phuah

In vivo base editing gene therapy for heterozygous familial hypercholesterolemia: a phase 1 trial

Nat Med. 2026 Mar 3. doi: 10.1038/s41591-026-04254-4. Online ahead of print.ABSTRACTHeterozygous familial hypercholesterolemia is a common genetic disorder characterized by lifelong elevation of serum low-density lipoprotein cholesterol (LDL-C) and premature atherosclerotic cardiovascular disease. Y

P Ping Wan

Multimodal AI-approach for the automatic screening of cardiovascular diseases based on nocturnal physiological signals

NPJ Cardiovasc Health. 2025 May 6;2(1):15. doi: 10.1038/s44325-025-00051-z.ABSTRACTThis study proposes a multimodal AI algorithm called the SleepCVD-Net to automatically screen CVDs based on nocturnal physiological recordings. We designed and implemented a multimodal AI algorithm, SleepCVD-Net, whic

Y Youngtae Kim

Physical activity and competitive sport safety for children affected by inherited cardiac conditions and selected acquired cardiomyopathies: emerging evidence and areas for further inquiry

Eur J Pediatr. 2026 Mar 4;185(3):160. doi: 10.1007/s00431-026-06768-y.ABSTRACTPhysicians tasked with caring for children with inherited cardiac conditions (ICCs) face complex decisions regarding safe participation in physical activity and competitive sport. Historically, concerns over sudden cardiac

S Scott Kendall

Impact of cardiometabolic risk factors and its management on the reversion and progression of arterial stiffness

NPJ Cardiovasc Health. 2025 Jul 8;2(1):36. doi: 10.1038/s44325-025-00074-6.ABSTRACTArterial stiffness is associated with a higher risk of adverse cardiovascular outcomes. Cardio-metabolic diseases increase the risk and progression of arterial stiffness, and its optimal management along with lifestyl

N Natalia Sofía De la Maza-Bustindui