Systematic serological testing in infective endocarditis: Limited clinical impact despite high usage-a 14-year cohort study

Int J Infect Dis. 2025 Dec;161:108151. doi: 10.1016/j.ijid.2025.108151. Epub 2025 Oct 25.ABSTRACTOBJECTIVES: To evaluate the clinical utility of systematic serological testing in infective endocarditis (IE), determine the prevalence of blood-culture negative IE (BCNIE), and characterize its clinical

N Noelia Ruiz-Alonso

Effect of Glucagon-Like Peptide-1 Receptor Agonists on Cardiometabolic Risk Factors in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Diabetes Metab Res Rev. 2026 Jan;42(1):e70111. doi: 10.1002/dmrr.70111.ABSTRACTPURPOSE: Although the cardiovascular benefits of GLP-1RAs in type 2 diabetes are established, their effects in type 1 diabetes remain unclear. This study aimed to evaluate the impact of GLP-1RAs as adjunctive therapy on c

Y Yizhu Chen

Longitudinal analysis of psychometric properties of the Seattle Angina Questionnaire among patients who underwent coronary artery bypass grafting in Serbia

Popul Health Metr. 2025 Dec 2;23(1):70. doi: 10.1186/s12963-025-00431-8.ABSTRACTBACKGROUND: The psychometric properties of Seattle Angina Questionnaire (SAQ) have not been assessed longitudinally among people who underwent coronary artery bypass grafting (CABG). The purpose of this study was to exam

I Ivan Nesic

Medication-related problems and contributing factors in patients with cardiovascular disorders in Ethiopia: a systematic review and meta-analysis

Syst Rev. 2025 Dec 2;14(1):241. doi: 10.1186/s13643-025-02992-z.ABSTRACTBACKGROUND: Cardiovascular diseases (CVDs) are a leading cause of mortality and disability globally. In Ethiopia, the management of CVDs faces significant challenges, particularly in addressing medication-related problems (MRPs)

M Mengistie Yirsaw Gobezie

Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes

Cardiovasc Diabetol. 2025 Dec 2. doi: 10.1186/s12933-025-03006-x. Online ahead of print.ABSTRACTBACKGROUND: Coronary artery disease (CAD) is a major contributor to cardiovascular events in individuals with diabetes. Quantification of coronary atherosclerotic burden is now feasible from coronary comp

M Matias Mäenpää

Data-driven phenotypic profiling of prediabetes reveals heterogeneous cardiometabolic risks in Chinese adults

Cardiovasc Diabetol. 2025 Dec 2. doi: 10.1186/s12933-025-03008-9. Online ahead of print.ABSTRACTBACKGROUND: The heterogeneous and complex nature of prediabetes presents a major challenge in identifying individuals predisposed to developing incident diabetes and related complications. We aimed to ide

X Xiaojing Jia

Where we work correlates with whether we receive cardiorespiratory preventive care services: Health and Retirement Study 2003-2018

BMC Public Health. 2025 Dec 2. doi: 10.1186/s12889-025-24748-z. Online ahead of print.ABSTRACTBACKGROUND: Uncontrolled dyslipidemia contributes to cardiovascular diseases, the leading cause of death among American workers, while influenza leads to significant absenteeism and presenteeism. Despite th

W Wan-Chin Kuo

Rethinking strategies for solving thyroid dysfunction at the heart of cardiovascular disease

Mol Med. 2025 Dec 2. doi: 10.1186/s10020-025-01351-x. Online ahead of print.ABSTRACTThroughout a person's lifetime, thyroid hormones (THs) have an outsized impact on cardiovascular health from prenatal heart development to adult cardiac contractile function and blood pressure regulation. Maintaining

V Viswanathan Rajagopalan

Disturbed homeostasis of iron metabolism in children from marginalised Roma communities

Eur J Clin Nutr. 2025 Dec 2. doi: 10.1038/s41430-025-01686-y. Online ahead of print.ABSTRACTOBJECTIVES: The purpose of this study was to compare selected iron markers (serum iron, total iron-binding capacity (TIBC), transferrin and ferritin concentration, transferrin saturation, and free haemoglobin

B Beáta Hubková

Clinical significance of lipoprotein(a) as a residual risk factor for atherosclerotic coronary plaque progression in statin-treated patients with coronary artery disease

Sci Rep. 2025 Dec 2. doi: 10.1038/s41598-025-30845-1. Online ahead of print.ABSTRACTLimited evidence exists on the role of lipoprotein(a) [Lp(a)] in the progression of atherosclerotic coronary plaques as assessed by intravascular imaging modality, particularly under low-density lipoprotein cholester

T Tatsuya Fukase

Omega-3 fatty acids and chemotherapy-induced toxicities: mechanisms and emerging evidence with a pediatric focus

Nutr Metab (Lond). 2025 Dec 2;22(1):150. doi: 10.1186/s12986-025-01044-6.ABSTRACTOmega-3 fatty acids are polyunsaturated fats that are essential for proper cell structure and function. The primary types of omega-3 fatty acids include alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docos

R R Maldonado-Salinas

Oral functional limitation and risk of frailty onset in older adults: a sex-stratified 4-Year cohort study with competing risk analysis

Geroscience. 2025 Dec 2. doi: 10.1007/s11357-025-02015-8. Online ahead of print.ABSTRACTBACKGROUND: Oral functional decline may contribute to frailty in older adults by affecting nutrition, physical performance, and psychosocial well-being. However, longitudinal evidence using rigorous analytic appr

K Kyung-Yi Do

Monocyte-Differentiation-Activated Fluorescent "Scout" Probe for Precise in Vivo Detection of Vulnerable Plaque

Adv Sci (Weinh). 2025 Dec 2:e15289. doi: 10.1002/advs.202515289. Online ahead of print.ABSTRACTPrecise identification of vulnerable plaque (VAP) is essential for the prevention of acute cardiovascular diseases, yet current molecular probes are hampered by poor VAP lesion penetration and high backgro

Z Zechuan Li

Hemodynamic effects of levosimendan in low cardiac output syndrome post-CABG refractory to standard inotropic therapy

Med Klin Intensivmed Notfmed. 2025 Dec 2. doi: 10.1007/s00063-025-01353-x. Online ahead of print.ABSTRACTBACKGROUND: Low cardiac output syndrome (LCOS) following coronary artery bypass grafting (CABG) remains a major cause of morbidity and mortality. Standard inotropes frequently provide only margin

P Priyanka Boettger

Capsaicin camphor and caffeic acid reduce adipogenesis and promote lipolysis with TRPV1 involvement

Sci Rep. 2025 Dec 2. doi: 10.1038/s41598-025-31073-3. Online ahead of print.ABSTRACTExcess fat accumulation contributes to metabolic disorders such as insulin resistance, type 2 diabetes, cardiovascular disease and increases risk of dementia. Promoting lipolysis and inhibiting adipogenesis through n

U Uzair Ali

Machine learning-based prediction of drug response in ischemia reperfusion animal model

Sci Rep. 2025 Dec 2;15(1):43012. doi: 10.1038/s41598-025-18620-8.ABSTRACTMyocardial ischemia is a major global contributor to mortality. While reperfusion therapy remains the most effective treatment, it paradoxically leads to myocardial ischemia-reperfusion (MI/R) injury, resulting in irreversible

A Asmaa Mohamed Abd ElGwad

The "Clinical Topics" from the Electronic Health Record of Patients with Rheumatoid Arthritis Before Initiating Targeted Therapies and Association with Future Treatment Course

ACR Open Rheumatol. 2025 Dec;7(12):e70118. doi: 10.1002/acr2.70118.ABSTRACTOBJECTIVE: Rheumatoid arthritis (RA) is a heterogeneous disease, with patients experiencing varied disease courses and responses to treatment. The objective of this study was to apply topic modeling to RA patient electronic h

J Jason Tang

Epidemiology of paediatric inherited arrhythmogenic diseases under "Real World" conditions: findings from a 10-year longitudinal study in Eastern Austria

Eur J Pediatr. 2025 Dec 3;184(12):815. doi: 10.1007/s00431-025-06646-z.ABSTRACTInherited arrhythmogenic diseases (IADs), such as long QT syndrome (LQTS), Brugada syndrome (BrS), arrhythmogenic right ventricular cardiomyopathy (ARVC), catecholaminergic polymorphic ventricular tachycardia (CPVT) and l

S Sulaima Albinni

A laboratory-based frailty index predicts mortality in ischemic stroke with carotid artery stenosis: a retrospective analysis from the MIMIC-IV database

Neurosurg Rev. 2025 Dec 3;49(1):43. doi: 10.1007/s10143-025-03979-z.ABSTRACTIschemic stroke (IS), particularly due to carotid artery stenosis (CAS), is a major global contributor to mortality and disability. Frailty, characterized by systemic physiological decline and reduced homeostatic reserves, h

M Muyuan Li

SynaptopathyDB integrates synaptic proteomes, genetic and phenotypic data to advance research on nervous system disorders

Sci Rep. 2025 Dec 2;15(1):42986. doi: 10.1038/s41598-025-26969-z.ABSTRACTSynaptic dysfunction resulting from pathogenic variants in genes encoding synaptic proteins is a major contributor to brain and behavioural disorders, collectively termed synaptopathies. To facilitate research into the genetic

O Oksana Sorokina

Large-scale characterisation of the nasal microbiome redefines Staphylococcus aureus colonisation status

Nat Commun. 2025 Dec 2;16(1):10415. doi: 10.1038/s41467-025-66564-4.ABSTRACTStaphylococcus aureus colonises the nose in humans, with individuals defined as persistent, intermittent or non-carriers. Unlike the gut microbiome, the nasal microbiome has not been studied in large numbers of people. Here,

D Dinesh Aggarwal

Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin

Signal Transduct Target Ther. 2025 Dec 3;10(1):394. doi: 10.1038/s41392-025-02486-3.ABSTRACTChronic inflammation in adipose tissue is widely recognized as a pivotal link connecting obesity to a spectrum of related chronic diseases, including type 2 diabetes, non-alcoholic fatty liver disease, and ca

J Jie Li

Multimodal Transformer-Based Electrocardiogram Analysis for Cardiovascular Comorbidity Detection: Model Development and Validation Study

JMIR Form Res. 2025 Dec 2. doi: 10.2196/80815. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular diseases (CVDs) remain the leading global cause of mortality, yet traditional electrocardiogram (ECG) interpretation suffers from subjective variability and limited sensitivity to complex patholog

Z Zi Yang

FIB-4 as an effective screening tool in psoriatic arthritis patients at high-risk for liver disease: a cross-sectional study using FibroScan

Rheumatology (Oxford). 2025 Dec 2:keaf640. doi: 10.1093/rheumatology/keaf640. Online ahead of print.ABSTRACTOBJECTIVES: To evaluate the performance of non-invasive screening tools in identifying metabolic dysfunction-associated steatotic liver disease (MASLD) causing clinically significant liver dis

K Katya Meridor