Incidence of refibrillation and shock-resistant ventricular fibrillation during OHCA when treated with a public access defibrillator: implications for CPR timing in lay rescuer-treated OHCA

Open Heart. 2026 Sep 22;13(2):e004173. doi: 10.1136/openhrt-2026-004173.ABSTRACTBACKGROUND: Out-of-hospital cardiac arrest (OHCA) treatment often requires multiple defibrillatory shocks due to failed defibrillation or refibrillation. The complete nature of refractory ventricular fibrillation (VF) is

A Amy Kernaghan

Postresuscitation Out-of-Hospital Cardiac Arrest Presentations to Australia's First Dedicated Cardiac Hospital: A Retrospective Audit of Outcomes and Emergency Department Access Factors

Emerg Med Australas. 2026 Oct;38(5):e70355. doi: 10.1111/1742-6723.70355.ABSTRACTOBJECTIVE: This study sought to characterise the demographics, arrest characteristics, clinical outcomes and ED access variables for out-of-hospital cardiac arrest (OHCA) presentations to the Victorian Heart Hospital (V

T Thenul Munasinghe

Left atrial strain assessment in mitral regurgitation: a systematic review

BMJ Open. 2026 Sep 22;16(9):e121972. doi: 10.1136/bmjopen-2026-121972.ABSTRACTOBJECTIVES: Mitral regurgitation (MR) induces progressive atrial remodelling and dysfunction, yet conventional metrics may underestimate early mechanical impairment. This systematic review synthesised evidence on left atri

O Omar Dabash

Oral antihypertensive agents in hypertensive pregnancies and adverse maternal and perinatal outcomes: study protocol for a target trial emulation using Dutch electronic health record data

BMJ Open. 2026 Sep 22;16(9):e121623. doi: 10.1136/bmjopen-2026-121623.ABSTRACTINTRODUCTION: Hypertensive disorders of pregnancy (HDP) are associated with maternal and neonatal morbidity. Although delivery is the definitive treatment, antihypertensive agents are often prescribed to control blood pres

R Rosalie J Hup

Role of MMPs in neutrophil biology

Enzymes. 2026;60:243-279. doi: 10.1016/bs.enz.2026.06.004. Epub 2026 Jun 29.ABSTRACTNeutrophils are central effectors of the innate immune system, providing rapid responses to harmful stimuli and contributing to both host defense and resolution of inflammation. Among their effector mechanisms is the

J Jennifer Vandooren

Tissue inhibitors of metalloproteinases (TIMPs)

Enzymes. 2026;60:135-168. doi: 10.1016/bs.enz.2026.05.001. Epub 2026 May 25.ABSTRACTThe extracellular matrix (ECM) is a dynamic structural network essential for cellular organization, continuously remodeled by proteases such as matrix metalloproteinases (MMPs). Under physiological conditions, these

N Niccolò Paoletti

Mitophagy's impact on obesity-related tissues

Int Rev Cell Mol Biol. 2026;406:87-130. doi: 10.1016/bs.ircmb.2025.12.003. Epub 2025 Dec 17.ABSTRACTObesity, a global health crisis, results from an energy imbalance, leading to metabolic dysfunction and associated conditions such as type 2 diabetes, cardiovascular disease, and metabolic dysfunction

R Rana El Nahas

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Eur J Prev Cardiol. 2026 Sep 23:zwag497. doi: 10.1093/eurjpc/zwag497. Online ahead of print.ABSTRACTRegular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evi

M Monica Tiberi

Development and Validation of a Machine Learning-Based Model for Predicting All-Cause Mortality Risk in Patients With Type 2 Diabetes Mellitus Combined With Hypertension: National Cohort Study

JMIR Med Inform. 2026 Sep 22;14:e85557. doi: 10.2196/85557.ABSTRACTBACKGROUND: Type 2 diabetes mellitus (T2DM) combined with hypertension significantly increases mortality risk, yet accurate risk prediction models remain limited.OBJECTIVE: We aimed to develop and validate machine learning-based mode

W Wenlong Ding