Histopathological evaluation in post-mortem renal biopsies of patients with COVID-19 and comorbidities: a case-control study

Sao Paulo Med J. 2026 Jan 19;144(1):e2024376. doi: 10.1590/1516-3180.2024.0376.R1.13102025. eCollection 2026.ABSTRACTBACKGROUND: Acute kidney injury is one of the main systemic complications of severe coronavirus disease 2019 (COVID-19).OBJECTIVES: To examine histopathological changes in post-mortem

S Samya Hamad Mehanna

Non-invasive imaging for monitoring nodular inflammatory lesions in hidradenitis suppurativa

Dermatol Reports. 2026 Jan 30. doi: 10.4081/dr.2026.10390. Online ahead of print.ABSTRACTDear Editor, Noninvasive skin diagnostic techniques are widely used in dermatology, and their role in the diagnosis and monitoring of inflammatory skin diseases is still being explored. Hidradenitis suppurativa

G Giuseppe Rizzuto

Implementing Cardiac Prehabilitation in Brazil: Building an Evidence-based Framework for Surgical Outcomes

Arq Bras Cardiol. 2025 Nov;122(10):e20250377. doi: 10.36660/abc.20250377.ABSTRACTPatients undergoing cardiac surgery often face multiple challenges, including comorbidities, frailty, and psychosocial factors, which complicate recovery. Multimodal prehabilitation programs have emerged as a promising

F Flavia Mazzoli-Rocha

Monitoring the lateral ventricles in the presence of intracranial hemorrhage using automated dual segmentation

Med Phys. 2026 Feb;53(2):e70308. doi: 10.1002/mp.70308.ABSTRACTBACKGROUND: Segmentation of intracranial hemorrhage (ICH) alongside the brain's ventricles can provide crucial information in the management stroke or traumatic brain injury (TBI). Automated computed tomography (CT) based segmentation is

E Elakkyen Murugesu

Mitochondria-Associated Endoplasmic Reticulum Membrane Biomarkers in Coronary Heart Disease and Atherosclerosis: A Transcriptomic and Mendelian Randomization Study

Curr Issues Mol Biol. 2026 Jan 12;48(1):75. doi: 10.3390/cimb48010075.ABSTRACTBACKGROUND: Coronary heart disease (CHD) remains a leading cause of morbidity and mortality worldwide. Mitochondria-associated endoplasmic reticulum membranes (MAMs) have recently emerged as critical mediators in cardiovas

J Junyan Zhang

Targeting the Ubiquitin-Proteasome System in Atrial Fibrillation: Mechanistic Insights and Translational Perspectives

Curr Issues Mol Biol. 2025 Dec 29;48(1):46. doi: 10.3390/cimb48010046.ABSTRACTAtrial fibrillation (AF) is the most common sustained arrhythmia, and its initiation and progression involve multiple mechanisms, including electrical remodeling, structural remodeling, inflammatory responses, and oxidativ

R Runze Huang

Effects of Micronutrients and Heavy Metals on Endothelial Function and Cardiovascular Risk in the Face of Environmental Changes

Curr Issues Mol Biol. 2025 Dec 27;48(1):41. doi: 10.3390/cimb48010041.ABSTRACTDynamic environmental changes significantly affect trace element balance and exposure to toxic metals, influencing vascular homeostasis. The endothelium, as a key regulator of vascular tone and inflammation, is highly sens

A Agata Doligalska-Dolina

Mechanistic Insights into Antioxidant Interventions Targeting Obesity-Induced Oxidative Stress in the Pathogenesis and Complications of Type 2 Diabetes Mellitus

Curr Issues Mol Biol. 2025 Dec 18;47(12):1063. doi: 10.3390/cimb47121063.ABSTRACTDiabetes mellitus (DM) is a complex, heterogeneous, hyperglycemic chronic metabolic disorder. Type 2 diabetes mellitus (T2DM) is characterized by progressive loss of insulin secretion from pancreatic islet β-cells due t

F Fani-Niki Varra

Increased Cardiovascular and Cerebrovascular Events in Patients with Lean vs. Non-Lean MASLD: A Multi-Center Analysis

Clin Transl Gastroenterol. 2026 Jan 30. doi: 10.14309/ctg.0000000000000974. Online ahead of print.ABSTRACTBACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a significant contributor to morbidity and mortality, linked to adverse cardiovascular outcomes. While ext

O Omar Al Ta'ani

What matters to cardiac patients? The impact of linking life goals to health goals on patients' intention-to-change-lifestyle: an online experiment

Br J Health Psychol. 2026 Feb;31(1):e70056. doi: 10.1111/bjhp.70056.ABSTRACTOBJECTIVES: Guidelines advocate goal setting for promoting lifestyle changes in cardiovascular disease (CVD) patients. This study investigates 1) preferences in health and life goal domains in CVD patients, 2) the impact of

R Renée V H IJzerman

Discovery of a Highly Potent and Selective Small-Molecule Inhibitor of In Vivo Anaerobic Choline Metabolism by Human Gut Bacteria

J Med Chem. 2026 Jan 30. doi: 10.1021/acs.jmedchem.5c01451. Online ahead of print.ABSTRACTTrimethylamine (TMA) Lyase is an enzyme expressed in human gut bacteria that plays a pivotal role in the formation of trimethylamine oxide (TMAO), a metabolite implicated in the development of heart failure. He

M Mariell Pettersson

Premature coronary artery disease in women: sex-specific risk factors, pathogenetic mechanisms and clinical implications

Ann Med. 2026 Dec;58(1):2613563. doi: 10.1080/07853890.2026.2613563. Epub 2026 Jan 30.ABSTRACTINTRODUCTION: Premature coronary artery disease (PCAD) in women, defined as onset ≤65 years, accounts for 20-30% of CAD cases. The clinical implications, pathogenic processes, and sex-specific risk factors

F Fei Li

Heart failure with preserved ejection fraction in adults with congenital heart disease

Eur Heart J. 2026 Jan 30:ehag017. doi: 10.1093/eurheartj/ehag017. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized in the general population, but the prevalence among adults with congenital heart disease (ACHD) is no

V Vanilla Maegaard Eriksen

Effect of Antihypertensive Treatment on Hypotension, Mortality and Length of Stay in Orthopedic Trauma and First Detected High Blood Pressure Adults in a Large Urban Hospital: A Retrospective Cohort Study

J Clin Hypertens (Greenwich). 2026 Feb;28(2):e70210. doi: 10.1111/jch.70210.ABSTRACTTrauma is a frequent cause of hospital admission in adults, and while arterial hypertension is common in the general population, reactive hypertension associated with trauma remains poorly studied from a therapeutic

C Carlos José Atencia

Imaging Flow Cytometric Assessment of del(17p) and amp(1q21) in Circulating Plasma Cells of Myeloma Patients

Curr Protoc. 2026 Feb;6(2):e70305. doi: 10.1002/cpz1.70305.ABSTRACTMultiple myeloma is a bone marrow-derived neoplastic proliferation of plasma cells with low levels of circulating tumor cells. Cytogenetic abnormalities are present in >90% of patients, when assessed by fluorescence in situ hybridiza

T Thomas I Mincherton

Peripheral autonomic dysregulation in response to standing: a new form associated with cardiovascular disease, mobility reduction, and cognitive alterations

Eur Heart J. 2026 Jan 30:ehaf1120. doi: 10.1093/eurheartj/ehaf1120. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Cardiovascular responses to standing are essential for maintaining cerebrovascular blood flow. While orthostatic blood pressure (BP) responses have been studied extensively, the rol

L L Xie

Executive Summary of the 2024 Philippine Clinical Practice Guidelines on the Diagnosis and Management of Acute Severe Blood Pressure Elevation

J Clin Hypertens (Greenwich). 2026 Feb;28(2):e70199. doi: 10.1111/jch.70199.ABSTRACTA recent survey in the Philippines, PRESYON-4, showed increasing prevalence of hypertension from 22% in the 1990s to 37% in 2021, of which only 52% were aware of their diagnosis. While rates of treatment and adherenc

D Deborah Ignacia D Ona

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage-driven Inflammation

Adv Sci (Weinh). 2026 Jan 30:e12494. doi: 10.1002/advs.202512494. Online ahead of print.ABSTRACTRecent studies suggest Streptococcus anginosus (SA) contributes to gastric disease beyond Helicobacter pylori, yet its pathogenic mechanisms remain unclear. This study demonstrates that SA-derived extrace

Y Ying Gong

Identification of a pathological feed-forward loop linking succinate, HIF1α signalling and vascular remodelling in abdominal aortic aneurysm

Eur J Clin Invest. 2026 Feb;56(2):e70170. doi: 10.1111/eci.70170.ABSTRACTBACKGROUND: Succinate is a metabolite with roles beyond energy production, including regulation of metabolic pathways, signalling and protein modifications. Abdominal aortic aneurysm (AAA) is a disease characterized by deleteri

S S Griepke

Frozen elephant trunk for acute type A aortic dissection: long-term outcomes over two decades

Eur Heart J. 2026 Jan 30:ehaf1117. doi: 10.1093/eurheartj/ehaf1117. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: The management of acute type A aortic dissection (ATAAD) has evolved considerably over the decades and a more aggressive approach with extended arch repair has been increasingly ado

W Wei-Guo Ma

Physician Perspectives on the Initial Diagnostic Strategy of Syncope in Older Patients Without Diagnostic Clues

Ann Noninvasive Electrocardiol. 2026 Mar;31(2):e70155. doi: 10.1111/anec.70155.ABSTRACTBACKGROUND: Syncope in adults at least 50 years old without structural or electrical heart disease has numerous potential causes, and uncertainty persists in up to 41% of patients. Guideline-directed investigation

S Stephanie Happ

Stroke Action Plan for Europe 2018-2030 (SAP-E): mid-term review and update

Eur Stroke J. 2026 Jan 1;11(1):aakaf026. doi: 10.1093/esj/aakaf026.ABSTRACTOBJECTIVES: Implementation of the Stroke Action Plan for Europe (2018-2030) (SAP-E) was initiated in 2019. It is now updated at mid-term to reflect and respond to challenges for stroke care in Europe in 2025.METHODS: The SAP-

H Hanne Christensen

Frequency and management of non-cardiac incidental findings on cardiac CT in patients with a suspected stroke

Eur Stroke J. 2026 Jan 1;11(1):aakaf027. doi: 10.1093/esj/aakaf027.ABSTRACTINTRODUCTION: Cardiac CT is increasingly used to screen for cardioembolism in stroke patients. We assessed the frequency and management of non-cardiac incidental findings on prospective ECG-gated cardiac CT in patients with a

C Chiel F P Beemsterboer

Transcranial doppler detected right-to-left shunt is common but not associated with MRI white matter hyperintensity burden: a cross-sectional study

Eur Stroke J. 2026 Jan 1;11(1):aakaf029. doi: 10.1093/esj/aakaf029.ABSTRACTINTRODUCTION: Right-to-left shunt (RLS) associated with a patent foramen ovale has been related with ischemic stroke. However, its relationship with MRI white matter hyperintensities (WMHs) remains debated. This cross-section

F Francesco Fisicaro