Cinnamaldehyde Ameliorates Ischemic Heart Failure by Targeting USP18 to Inhibit [Formula: see text]-Adrenergic Receptor Ubiquitination and Suppress TAK1/NF-[Formula: see text]B Signaling Pathway

Am J Chin Med. 2026;54(3):911-930. doi: 10.1142/S0192415X26500333. Epub 2026 Apr 30.ABSTRACTCinnamaldehyde, a bioactive constituent derived from Cinnamomum cassia Presl, exhibits diverse pharmacological effects, including vasodilatory and antihypertensive properties. However, its pharmacological imp

Z Zhao Chen

Polygenic Risk Identifies Older Adults Who May Benefit From Aspirin for the Primary Prevention of Ischemic Stroke

Stroke. 2026 May 8. doi: 10.1161/STROKEAHA.125.054979. Online ahead of print.ABSTRACTBACKGROUND: Low-dose aspirin is no longer recommended for routine primary prevention in older adults due to bleeding risks outweighing vascular benefits. We hypothesized that an integrative polygenic score (iPGS) co

C Chenglong Yu

Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study

CONCLUSIONS: Physiological thresholds for angina (FFR(angina) and RFR(angina)) are highly individualized, vary with cardiac workload, and are consistently lower than the universal ischemia-based thresholds used to guide revascularization. These findings support integrating personalized, symptom-link

F Fiyyaz Ahmed-Jushuf

"Hedgehog 3D artifact" - an uncommon intracardiac air embolic complication of the M-TEER procedure

No abstractKardiol Pol. 2026 May 8. doi: 10.33963/v.phj.112563. Online ahead of print.NO ABSTRACTPMID:42100804 | DOI:10.33963/v.phj.112563

B Barbara Szlosarczyk

Managing metabolic syndrome in bipolar disorder: multidisciplinary monitoring and treatment strategies

Front Psychiatry. 2026 Apr 22;17:1699908. doi: 10.3389/fpsyt.2026.1699908. eCollection 2026.ABSTRACTBACKGROUND: Bipolar disorder (BD) is a chronic psychiatric illness associated with high rates of medical comorbidities, among which metabolic syndrome (MetS) is particularly prevalent and consequentia

J Jorge C Correia

Electronic medical record-based causal network modeling for acute myocardial infarction diagnosis in the emergency department

iScience. 2026 Apr 16;29(5):115742. doi: 10.1016/j.isci.2026.115742. eCollection 2026 May 15.ABSTRACTFor the acute myocardial infarction (AMI) diagnosis in the emergency department, the atypical manifestations and limited information lead to clinical challenge. Data-driven methods often fail in the

B Bo-Yuan Li

Interpreting the PISCES trial on fish oil in hemodialysis patients: lessons on trial design, biological exposure, and outcome measurement

Clin Kidney J. 2026 Apr 16;19(5):sfag118. doi: 10.1093/ckj/sfag118. eCollection 2026 May.ABSTRACTPatients receiving maintenance hemodialysis experience an exceptionally high cardiovascular risk, characterized by frequent recurrent events and a longstanding lack of effective preventive therapies. Mos

J Jaime Mazón-Ruiz

Lipid-lowering therapy for primary prevention of cardiovascular disease in adults aged 75 years and older: a narrative review

Int J Cardiol Cardiovasc Risk Prev. 2026 Apr 28;30:200646. doi: 10.1016/j.ijcrp.2026.200646. eCollection 2026 Sep.ABSTRACTBACKGROUND: Adults aged 75 years and older carry the highest absolute risk of cardiovascular disease (CVD) yet remain substantially underrepresented in randomized trials evaluati

D Dominique Stephan

Extracting Genetically-Imputed Causal Features From ECG Data

Stat Anal Data Min. 2025 Aug;18(4):e70026. doi: 10.1002/sam.70026. Epub 2025 Jul 2.ABSTRACTAtrial fibrillation (AF), a cardiac arrhythmia characterized by an abnormal and rapid heartbeat, has the potential to develop into stroke, heart failure, and, ultimately, mortality. The electrocardiogram (ECG)

Y Yuchen Yao

A nationwide Scottish cohort study of the association between pre-existing mental illness and out-of-hospital cardiac arrest survival

Resusc Plus. 2026 Jan 12;29:101218. doi: 10.1016/j.resplu.2026.101218. eCollection 2026 May.ABSTRACTAIM: To investigate the association between pre-existing mental illness and out-of-hospital cardiac arrest (OHCA) survival.METHODS: We performed a nationwide retrospective cohort study using Scottish

R Raied Alotaibi

Mediterranean Diet and the Risk of Stroke Subtypes in Women: The California Teachers Study

Neurol Open Access. 2026 Mar;2(1):e000062. doi: 10.1212/wn9.0000000000000062. Epub 2026 Feb 4.ABSTRACTBACKGROUND: Mediterranean diet (MeDi) has been linked to lower incidence of cardiovascular and neurodegenerative diseases, and overall mortality, in several prospective studies. There is limited dat

A Ayesha Z Sherzai

Construction of a Diagnostic Model and Drug Prediction for Postischemic Stroke Cognitive Impairment Based on Machine Learning Screening of Lactate Metabolism- and Pyroptosis-Related Genes

Hum Mutat. 2026 May 6;2026:2963117. doi: 10.1155/humu/2963117. eCollection 2026.ABSTRACTReliable molecular biomarkers for poststroke cognitive impairment (PSCI) remain limited. Using publicly available bulk transcriptomic and single-cell RNA-seq datasets from GEO, we investigated lactate metabolism-

S Shulong Ge

Integrated transcriptomic profiling combined with in vitro validation reveals the involvement of TMEM140 in the link between periodontitis and brain aging

Front Aging Neurosci. 2026 Apr 22;18:1761218. doi: 10.3389/fnagi.2026.1761218. eCollection 2026.ABSTRACTOBJECTIVE: Periodontitis (PD) is a prevalent chronic inflammatory disorder in adults, and moderate-to-severe PD (Stage II-III/IV) may accelerate brain aging and neurodegenerative changes via the p

H HaoRan Zhao

Evidence of variations in genetic prevalence for loss-of-function PKP2 variants between individuals with European and African ancestry

Genet Med Open. 2026 Apr 3;4:104397. doi: 10.1016/j.gimo.2026.104397. eCollection 2026.ABSTRACTPURPOSE: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited condition associated with increased risk for ventricular arrhythmias and sudden cardiac death. Prior ARVC studies contained m

A Alexandra Winters

Risk factors for trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients

Front Oncol. 2026 Apr 22;16:1819766. doi: 10.3389/fonc.2026.1819766. eCollection 2026.ABSTRACTOBJECTIVE: To analyze the risk factors for cardiotoxicity induced by trastuzumab in human epidermal growth factor receptor 2 (HER2) -positive breast cancer patients and provide a basis for early clinical in

H Hao Zhang

Functional Limb Preservation after Surgical Distal Venous Arterialization with Free Flap in Chronic Limb-Threatening Ischemia with Severe Foot Arterial Disease

Surg Case Rep. 2026;12(1):26-0099. doi: 10.70352/scrj.cr.26-0099. Epub 2026 Apr 28.ABSTRACTINTRODUCTION: In chronic limb-threatening ischemia (CLTI), especially with diabetes and dialysis dependence, below-the-ankle arterial lesions and severe calcification often limit distal bypass options. While s

C Chihiro Nakai

Translational insights into miR-126 and miR-423: biomarkers and therapeutic targets in cancer, cardiovascular, metabolic and kidney diseases

Front Mol Biosci. 2026 Apr 22;13:1813285. doi: 10.3389/fmolb.2026.1813285. eCollection 2026.ABSTRACTMicroRNAs (miRNAs) are key post-transcriptional regulators that orchestrate complex gene regulatory networks controlling endothelial function, metabolic adaptation, inflammation, and tissue remodeling

M Małgorzata Rodzoń-Norwicz

A review of the protection mechanisms of ginsenoside CK on cardiovascular disease and stroke

Front Pharmacol. 2026 Apr 22;17:1777145. doi: 10.3389/fphar.2026.1777145. eCollection 2026.ABSTRACTCardiovascular disease (CVD), comprising coronary artery disease, myocardial infarction, arrhythmias, heart failure, and hypertension, predominantly originates from dysfunction or obstruction within th

H Hui-Ting Chan

The efficacy and safety of ginseng berry saponin for heart failure: a systematic review and meta-analysis

Front Pharmacol. 2026 Apr 22;17:1712401. doi: 10.3389/fphar.2026.1712401. eCollection 2026.ABSTRACTBACKGROUND: Ginseng berry saponin (GBS), the primary bioactive constituent of Panax ginseng C.A. Mey (known as "Renshen" in Chinese) berries, exhibits cardioprotective properties, including anti-inflam

J Jing Wang

Flow Cytometric Detection of Biomarker Changes in CFDA-SE-Labelled Plasma Extracellular Vesicles Using a Rodent Pregnancy Model of Prenatal Diagnostics

J Extracell Biol. 2026 May 5;5:e70145. doi: 10.1002/jex2.70145. eCollection 2026 May.ABSTRACTCirculating extracellular vesicles (EVs) offer a promising source of non-invasive biomarkers for congenital disease diagnostics but robust assays for their detection are lacking. We used a rodent pregnancy m

P Petra Adamova

Multimorbidity research in dementia: it's time to shift to a person-centred approach

Front Dement. 2026 Apr 22;5:1791795. doi: 10.3389/frdem.2026.1791795. eCollection 2026.ABSTRACTPeople with dementia often live with several long-term conditions (known as multimorbidity). These conditions interact with dementia in complex ways and influence symptoms, care needs, and quality of life.

S Subhashisa Swain

Adherence to Medication, Mediterranean Diet, and Physical Activity and Their Predictors in Heart Failure Patients

Iran J Med Sci. 2026 Apr 1;51(4):236-247. doi: 10.30476/ijms.2025.106829.4113. eCollection 2026 Apr.ABSTRACTBACKGROUND: Adherence to prescribed medications, a healthy diet, and regular physical activity is essential for the optimal management of heart failure (HF). Therefore, the present study aimed

M Maryam Afshari

Prediction of Major Adverse Cardiovascular Events in Peripheral Artery Disease: Integrating Metabolomics and Proteomics for Risk Stratification

Research (Wash D C). 2026 May 6;9:1229. doi: 10.34133/research.1229. eCollection 2026.ABSTRACTPeripheral artery disease (PAD) confers elevated risk for major adverse cardiovascular events (MACE), yet accurate risk stratification remains a challenge, particularly among patients with advanced disease

W Wenxin Zhao

Prevalence of cardiovascular-kidney-metabolic syndrome in areas of Southern China where ethnic minority populations reside: a cross-sectional study

Front Endocrinol (Lausanne). 2026 Apr 22;17:1818782. doi: 10.3389/fendo.2026.1818782. eCollection 2026.ABSTRACTINTRODUCTION: Epidemiological data and the comorbidity situation of cardiovascular-kidney-metabolic disease (CKM) in ethnic minority regions of southern China are lacking. This study aimed

K Kehui Li