ACS Chem Neurosci. 2025 Nov 28. doi: 10.1021/acschemneuro.5c00638. Online ahead of print.ABSTRACTVisualizing signaling systems in the brain with high spatial resolution is critical to understanding brain function and to develop therapeutics. Especially, enzymes are often regulated on the post-transl
Sci Adv. 2025 Nov 28;11(48):eadx1195. doi: 10.1126/sciadv.adx1195. Epub 2025 Nov 28.ABSTRACTSince the advent of optogenetics, great progress has been made in developing tools to modulate and detect cellular activity using light. We present a two-component optogenetic silencing tool, RoCK (rhodopsin
Adv Sci (Weinh). 2025 Nov 28:e16021. doi: 10.1002/advs.202516021. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) presents a global health burden with cardiovascular disease (CVD) as its leading cause of mortality. A rapid clinical-adaptable microfluidic workflow for label-free CVD ris
Nurs Open. 2025 Dec;12(12):e70385. doi: 10.1002/nop2.70385.ABSTRACTAIM: To describe the quality of life in patients with chronic heart failure and coexisting obstructive sleep apnoea, and to examine the effect of common sleep-disordered breathing treatments on quality of life, functional capacity an
Am J Nephrol. 2025 Nov 28:1-15. doi: 10.1159/000549804. Online ahead of print.ABSTRACTBackground Renin-angiotensin system inhibitors (RASi) are critical for cardiovascular diseases (CVD), but adverse effects sometimes lead to discontinuation, raising concerns about impacts on major outcomes. Althoug
FEBS J. 2025 Nov 28. doi: 10.1111/febs.70341. Online ahead of print.ABSTRACTACT-132577 is a newly approved anti-hypertensive agent in the treatment of hypertension and related cardiovascular diseases. However, its exact roles and underlying mechanisms beyond simple blood pressure regulation remain l
Pacing Clin Electrophysiol. 2025 Nov 28. doi: 10.1111/pace.70094. Online ahead of print.ABSTRACTBACKGROUND: Implantable cardioverter defibrillator (ICD) therapy can prevent sudden cardiac death, but poses a risk of inappropriate device therapy (IDT), which is linked to worse outcomes and reduced qua
Telemed J E Health. 2025 Nov 20. doi: 10.1177/15305627251369830. Online ahead of print.ABSTRACTBackground: Cardiovascular diseases remain a leading cause of global morbidity and mortality. Cardiac rehabilitation (CR), particularly cardiac physiotherapy, is crucial for secondary prevention; yet acces
FASEB J. 2025 Dec 15;39(23):e71266. doi: 10.1096/fj.202503352R.ABSTRACTCryptogenic stroke represents 25%-40% of ischemic strokes, with many cases harboring unrecognized large artery atherosclerosis (LAA) requiring specific secondary prevention. In this multicenter pilot study, we developed a metabol
J Endocrinol Invest. 2025 Nov 28. doi: 10.1007/s40618-025-02770-7. Online ahead of print.ABSTRACTBACKGROUND: Endothelial dysfunction may contribute to the increased cardiovascular risk associated with thyroid diseases. This systematic review and meta-analysis aimed to assess endothelial function, ev
J Cancer Surviv. 2025 Nov 28. doi: 10.1007/s11764-025-01938-7. Online ahead of print.ABSTRACTPURPOSE: Endometrial cancer is the most common gynaecological cancer, with rising incidence contributing to a growing population at risk of long-term health issues post-treatment. Cardiovascular disease is t
Curr Atheroscler Rep. 2025 Nov 28;27(1):119. doi: 10.1007/s11883-025-01366-z.ABSTRACTPURPOSE OF REVIEW: In this paper we review recent advancements in the diagnosis and management of atrial fibrillation through machine learning (ML).RECENT FINDINGS: Machine learning models developed from clinical re
Sleep Breath. 2025 Nov 28;29(6):369. doi: 10.1007/s11325-025-03546-2.ABSTRACTBACKGROUND: The Mediterranean diet (Med-Diet) is well known for its protective effects against noncommunicable diseases and overall mortality, thanks to its anti-inflammatory, antioxidant, and neuroprotective properties. Si
Mol Biol Rep. 2025 Nov 28;53(1):137. doi: 10.1007/s11033-025-11298-1.ABSTRACTBACKGROUND: Prolonged hypoxia is known to induce reactive oxygen species (ROS) accumulation, leading to cellular damage, particularly in cardiac cells. MicroRNAs (miRNAs) have emerged as key regulators in cellular responses
Eur J Pediatr. 2025 Nov 28;184(12):802. doi: 10.1007/s00431-025-06657-w.ABSTRACTDifferentiating athlete's heart from hypertrophic cardiomyopathy (HCM) in pediatric populations is challenging due to overlapping electrocardiographic (ECG) features. This systematic review and meta-analysis evaluated EC
J Epidemiol Glob Health. 2025 Nov 28;15(1):141. doi: 10.1007/s44197-025-00487-7.ABSTRACTBACKGROUND: Forced displacement has created widespread health disparities, with refugees experiencing disproportionate risks of chronic conditions like hypertension. In the United States, a limited understanding
Pharmacoeconomics. 2025 Nov 28. doi: 10.1007/s40273-025-01560-6. Online ahead of print.ABSTRACTThis illustration uses the Scottish Cardiovascular Disease (CVD) Policy Model as a case study to provide a comprehensive, step-by-step guide to building a discrete event simulation (DES) model in R. It is
Sci Prog. 2025 Oct-Dec;108(4):368504251401247. doi: 10.1177/00368504251401247. Epub 2025 Nov 28.ABSTRACTChronic limb-threatening ischemia (CLTI) remains a challenge, especially in the ultra-complex patient population with a history of extensive endovascular revascularization and peripheral arterial
Basic Res Cardiol. 2025 Nov 28. doi: 10.1007/s00395-025-01150-9. Online ahead of print.ABSTRACTHeart failure with preserved ejection fraction (HFpEF) accounts for more than half of all heart failure cases, and its prevalence is projected to rise further. Among its heterogeneous subtypes, cardiometab
Nutr Hosp. 2025 Nov 17. doi: 10.20960/nh.05709. Online ahead of print.ABSTRACTINTRODUCTION: this study evaluated the predictive value of inflammatory indices including neutrophil-percentage-to-albumin ratio (NPAR), systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and eo
Nephrol Dial Transplant. 2025 Nov 28:gfaf256. doi: 10.1093/ndt/gfaf256. Online ahead of print.ABSTRACTSkeletal fragility has long been overlooked by the nephrology community, despite patients with chronic kidney disease (CKD) facing double the risk of hip fracture compared with the general populatio
JACC Case Rep. 2025 Nov 28:106250. doi: 10.1016/j.jaccas.2025.106250. Online ahead of print.ABSTRACTBACKGROUND: Papillary fibroelastomas (PFEs) are benign primary cardiac tumors. The occurrence of multiple PFEs on a single valve is exceedingly rare.CASE SUMMARY: A 72-year-old woman with coronary art
JACC Case Rep. 2025 Nov 28:106231. doi: 10.1016/j.jaccas.2025.106231. Online ahead of print.ABSTRACTBACKGROUND: Pseudoxanthoma elasticum (PXE) is a rare disease resulting from ABCC6 gene mutations; it causes elastic fiber calcification with unclear arterial stenosis mechanisms.CASE SUMMARY: A 60-yea
JACC Case Rep. 2025 Nov 28:106116. doi: 10.1016/j.jaccas.2025.106116. Online ahead of print.ABSTRACTTargeted drug therapy and subsequent transcatheter closure are effective in treating atrial septal defects in patients with severe pulmonary arterial hypertension. Nevertheless, despite sufficient pha
