Heart Attack Education and EMS Response in High-Risk, Low EMS Usage Areas: A Stepped-Wedge Cluster-Randomized Trial

JAMA Netw Open. 2026 Apr 1;9(4):e268823. doi: 10.1001/jamanetworkopen.2026.8823.ABSTRACTIMPORTANCE: Patient delays in recognizing and acting on acute coronary syndrome (ACS) symptoms worsen outcomes.OBJECTIVE: To evaluate the effectiveness of a heart attack education intervention (Heart Matters) aim

J Janet E Bray

Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry

Alzheimers Dement. 2026 Apr;22(4):e71433. doi: 10.1002/alz.71433.ABSTRACTINTRODUCTION: Neuropathological studies indicate a strong association between Alzheimer's disease (AD) and stroke, yet the molecular mechanisms underlying this association remain unclear.METHODS: Local genetic correlation analy

N Nicholas R Ray

The association between height-indexed skeletal muscle mass and cardiometabolic multimorbidity is largely accounted for by body mass index: findings from an older UK cohort

Geroscience. 2026 Apr 27. doi: 10.1007/s11357-026-02276-x. Online ahead of print.ABSTRACTSeveral studies suggest that higher skeletal muscle mass (SMM) may be associated with a lower risk of adverse cardiometabolic outcomes. However, the relationship between SMM and cardiometabolic multimorbidity (C

S Setor K Kunutsor

Twenty-four-hour blood pressure and CSF biomarkers of Alzheimer's disease and related dementias in a community cohort

Geroscience. 2026 Apr 27. doi: 10.1007/s11357-026-02220-z. Online ahead of print.ABSTRACTHypertension in midlife is associated with increased dementia risk, yet its relationship with early pathological changes of Alzheimer's disease and related dementias (ADRD) remains unclear. Unlike office blood p

M Madeline Gibson

Potential of Antioxidant and Cardioprotective Activity of a New Pyridoxine and Fumaric Acid Derivative as an Inductor of Transcription Factor Nrf2

Bull Exp Biol Med. 2026 Apr 27. doi: 10.1007/s10517-026-06667-0. Online ahead of print.ABSTRACTThe aim of the study was to evaluate the biological activity of a new type of cardioprotectors, activators of Nrf2, based on pyridoxine and fumaric acid derivatives in vitro and in vivo. It was found that

A A A Balakina

Scoping Review on True and Relative Bradycardia in Trauma: How to Approach Bradycardia in Traumatic Brain Injury

J Cardiovasc Transl Res. 2026 Apr 27;19(1):50. doi: 10.1007/s12265-026-10772-w.ABSTRACTBrain-heart interactions have garnered considerable interest in the landscape of traumatic brain injury (TBI). This scoping review focused on bradycardia caused by high intracranial pressure (ICP), brainstem injur

A Ayman El-Menyar

Pan-cancer analysis and experimental validation identify CYP19A1 as a prognostic biomarker and oncogenic driver associated with tumor immune microenvironment regulation in gastrointestinal cancers

No abstractDiscov Oncol. 2026 Apr 27. doi: 10.1007/s12672-026-04998-y. Online ahead of print.NO ABSTRACTPMID:42043681 | DOI:10.1007/s12672-026-04998-y

Z Zongrong Lin

Bone microarchitectural degradation in hypertensive patients: a population-based study

Arch Osteoporos. 2026 Apr 27;21(1):73. doi: 10.1007/s11657-026-01703-y.ABSTRACTHypertension is associated with increased fracture risk. However, evidence on its association with BMD is conflicting. Here, we demonstrate that hypertensive patients have lower trabecular bone scores compared to normoten

F Fabio Bioletto

Subarachnoid hemorrhage: epidemiology, risk factors, pathogenesis, and clinical therapies

Mol Biomed. 2026 Apr 27;7(1):59. doi: 10.1186/s43556-026-00455-y.ABSTRACTSubarachnoid hemorrhage (SAH) is an extremely lethal cerebrovascular emergency that can lead to severe long term neurological deficits. Modern research evidence indicates that the incidence of SAH varies significantly across di

H Hangyu Shen

Berberine Ameliorates Atherosclerosis by Promoting Mitochondrial Biogenesis via SIRT1/PGC-1α Signaling Pathway

Chin J Integr Med. 2026 Apr 27. doi: 10.1007/s11655-026-4037-8. Online ahead of print.ABSTRACTOBJECTIVE: To investigate berberine (BBR) promotes mitochondrial biogenesis via the silent mating type information regulation 2 homolog 1/peroxisome proliferator-activated receptor gamma coactivator 1 alpha

S Si-Yu Wang

From Mechanism to Therapy: Establishing an Integrated Framework for the Regulation and Intervention of Matrix Vesicles in Vascular Calcification

No abstractCardiovasc Drugs Ther. 2026 Apr 27. doi: 10.1007/s10557-026-07881-8. Online ahead of print.NO ABSTRACTPMID:42043663 | DOI:10.1007/s10557-026-07881-8

M Mincheng Yu

Immune Dysregulation and Persistent Symptoms: Insights into T Cell Dynamics in Post-COVID among Athletes from the CoSmo-S Study

No abstractJ Clin Immunol. 2026 Apr 27. doi: 10.1007/s10875-026-02020-2. Online ahead of print.NO ABSTRACTPMID:42043637 | DOI:10.1007/s10875-026-02020-2

M Miriam Ringleb

Diagnostic value of hypoxia-inducible factor 1 alpha and adrenomedullin in acute mesenteric ischemia

Eur J Trauma Emerg Surg. 2026 Apr 27;52(1):148. doi: 10.1007/s00068-026-03195-4.ABSTRACTBACKGROUND: This study aims to evaluate the diagnostic significance of adrenomedullin and hypoxia-inducible factor 1 alpha (HIF1-alpha) levels in an animal model of acute mesenteric ischemia.MATERIALS AND METHODS

E Enes Bayindir

Association Between Trajectories of Estimated Glucose Disposal Rate (eGDR) and Incident Cardiovascular Disease in a Chinese Population: A Longitudinal Cohort Study

No abstractEndocrine. 2026 Apr 27;91(1):143. doi: 10.1007/s12020-026-04604-9.NO ABSTRACTPMID:42043498 | DOI:10.1007/s12020-026-04604-9

Q Qihang Kong

Kaempferol attenuates LPS-induced inflammatory responses in H9c2 cells through involvement of the IL-6/JAK2/STAT3 pathway

Mol Biol Rep. 2026 Apr 27;53(1):673. doi: 10.1007/s11033-026-11855-2.ABSTRACTBACKGROUND: Kaempferol (Kae), a flavonoid compound, has shown considerable potential in preventing and treating cardiovascular diseases and ameliorating myocardial damage. However, its underlying mechanisms remain complex a

H Hongyi Yue

Scrib organizes cortical actomyosin clusters to maintain adherens junctions and angiogenic sprouting

J Cell Biol. 2026 Jun 1;225(6):e202503146. doi: 10.1083/jcb.202503146. Epub 2026 Apr 27.ABSTRACTSpatiotemporal control of adherens junction fluidity and integrity is critical for angiogenesis, but underlying mechanisms are incompletely understood. To identify unappreciated regulators of endothelial

L Lakyn N Mayo

Coronary Microvascular Resistance as a Predictor of the Placebo-Controlled Response to Percutaneous Coronary Intervention: Microvascular-Stratified Analysis of ORBITA

CONCLUSIONS: The placebo-controlled benefit of PCI was greater in patients with lower MVR(CFD), but interactions with symptom-based endpoints were modest. For patients with severe single-vessel disease taking optimal medical therapy, microvascular dysfunction may attenuate the functional and symptom

D Daniel J Taylor

Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Ventricular Premature Complexes (TREAT-PVC): A Randomized Clinical Trial

JACC Clin Electrophysiol. 2026 Mar 3:S2405-500X(26)00016-2. doi: 10.1016/j.jacep.2026.01.011. Online ahead of print.ABSTRACTBACKGROUND: Low-level tragus stimulation (LLTS) of the auricular branch of the vagus nerve at the tragus reduces atrial fibrillation burden. Its efficacy on premature ventricul

N Nan Wu

Structural Evolution and Immunomodulatory Versatility of Fungal Immunomodulatory Proteins: Insights into Mechanisms and Bioproduction Strategies

J Agric Food Chem. 2026 Apr 27. doi: 10.1021/acs.jafc.6c00623. Online ahead of print.ABSTRACTFungal immunomodulatory proteins (FIPs) are low-molecular-weight proteins from macrofungi that share the potential to modulate immune responses. Structurally, they fall into five subgroups, with the Fve-type

H Hongyu Chen

Integrative Insights into the Immunopathogenesis and Organ-Specific Immunological Mechanisms of Long COVID: A Narrative Review

Viruses. 2026 Apr 10;18(4):458. doi: 10.3390/v18040458.ABSTRACTLong COVID (LC), also referred to as post-acute sequelae of SARS-CoV-2 infection, is characterized by persistent symptoms originating 3 months following acute COVID-19, lasting for at least two months and frequently affecting individuals

S Supriya Mahajan

Health Risk and Pathogenesis of PM2.5 in Human Systems

Fine particulate matter (PM(2.5)) poses a significant global environmental health threat and is closely associated with diseases across multiple organ systems. This review systematically summarizes the toxic effects and underlying mechanisms of PM(2.5) in the respiratory, cardiovascular, nervous, im

R Ronghua Zhang

Muscle-Specific Dosing of OnabotulinumtoxinA in Post-Stroke Upper-Limb Spasticity: A Descriptive Literature Review

Toxins (Basel). 2026 Apr 21;18(4):192. doi: 10.3390/toxins18040192.ABSTRACTBACKGROUND: Botulinum neurotoxin type A is widely used in the management of post-stroke upper-limb spasticity; however, many studies report total injected doses rather than muscle-specific dosing, limiting clinical applicabil

M Małgorzata Cisowska-Adamiak

Quantifying the Contribution of Nondialytic Factors Affecting Predialysis Serum Phosphate Level When Comparing Hemodiafiltration with Hemodialysis

Toxins (Basel). 2026 Apr 8;18(4):179. doi: 10.3390/toxins18040179.ABSTRACTHyperphosphatemia is a major complication in patients with kidney failure undergoing dialysis and is strongly associated with cardiovascular disease, vascular calcification, and increased mortality. Conventional management rel

J John T Daugirdas

Pericoronary Fat Attenuation Index and MRI-Derived Coronary Flow Reserve: A Comparative Study in Suspected Versus Known Coronary Artery Disease

Tomography. 2026 Apr 13;12(4):55. doi: 10.3390/tomography12040055.ABSTRACTBACKGROUND: The fat attenuation index (FAI) derived from coronary computed tomography angiography (CTA) is an emerging imaging biomarker of perivascular inflammation. Coronary flow reserve (CFR), assessed by phase-contrast (PC

R Ryoya Takizawa