Attenuated sensorimotor hemodynamic responses and altered cortical dynamics during passive proprioceptive-related stimulation after stroke: a multidimensional fNIRS study

Front Neurol. 2026 Sep 16;17:1848276. doi: 10.3389/fneur.2026.1848276. eCollection 2026.ABSTRACTOBJECTIVE: This study aimed to use functional near-infrared spectroscopy to investigate abnormalities in cortical activity and dynamic network mechanisms associated with proprioceptive processing after st

H Hui Sun

Serum uric acid variability and short-term mortality in chronic kidney disease: a retrospective cohort study with independent replication in MIMIC-IV

Front Nutr. 2026 Sep 16;13:1919779. doi: 10.3389/fnut.2026.1919779. eCollection 2026.ABSTRACTINRODUCTION: Within-person variation in serum uric acid (SUA) may reflect clinical instability, but its association with outcomes in chronic kidney disease (CKD) is uncertain.METHODS: We studied 10,556 adult

F Fan Zhu

Effectiveness of chatbot interventions in individuals for hypertension management: a systematic review and narrative synthesis

Front Digit Health. 2026 Sep 16;8:1911937. doi: 10.3389/fdgth.2026.1911937. eCollection 2026.ABSTRACTINTRODUCTION: Hypertension is a major global risk factor for cardiovascular disease and requires long-term management. Recently, digital health tools such as chatbots have been introduced to support

S Shahwar Fatima Ansari

Metabolically unhealthy normal weight is associated with subclinical carotid atherosclerosis: cross-sectional and longitudinal evidence from a Chinese health examination cohort

Front Endocrinol (Lausanne). 2026 Sep 16;17:1925899. doi: 10.3389/fendo.2026.1925899. eCollection 2026.ABSTRACTBACKGROUND AND AIMS: Whether metabolically unhealthy normal weight (MUNW) is associated with subclinical carotid atherosclerosis (SCAS) and how its risk compares with that of metabolically

S Sai Zhang

RBM15 affects mitophagy in intracerebral hemorrhage by promoting E2F1 nuclear translocation via NXF1

Front Immunol. 2026 Sep 16;17:1892295. doi: 10.3389/fimmu.2026.1892295. eCollection 2026.ABSTRACTNuclear mRNA transport is essential for maintaining mRNA homeostasis and normal cellular functions; however, the mechanisms regulating the nuclear transport of E2F transcription factor 1 (E2F1) mRNA rema

J Jiwei Sun

Sex-specific threshold effect of albumin-corrected fructosamine on diabetic retinopathy: a nonlinear relationship in women but linear in men - a cross-sectional study

Front Endocrinol (Lausanne). 2026 Sep 16;17:1935387. doi: 10.3389/fendo.2026.1935387. eCollection 2026.ABSTRACTBACKGROUND: Albumin-corrected fructosamine (AlbF) is a short-term glycemic marker that can substitute for HbA1c when HbA1c is unreliable. Studies have linked AlbF to diabetic retinopathy (D

Q Qiyun Long

The impact of statin therapy on amputation risk in patients with diabetic foot infection: a retrospective cohort study from Jordan

Front Endocrinol (Lausanne). 2026 Sep 16;17:1922755. doi: 10.3389/fendo.2026.1922755. eCollection 2026.ABSTRACTBACKGROUND: Diabetic foot infection (DFI) is a major cause of non-traumatic lower-limb amputation and is associated with poor survival outcomes. Identifying therapies that reduce progressio

J Jana Abdallah

Abnormal coordination of executive control network and default mode network in cognitive impairment after deep nuclei intracerebral hemorrhage

Front Neurol. 2026 Sep 16;17:1915567. doi: 10.3389/fneur.2026.1915567. eCollection 2026.ABSTRACTOBJECTIVE: This study investigated the macroscopic neural mechanisms of cognitive impairment after Deep Nuclei Intracerebral Hemorrhage (DNICH) from the dimensions of brain activity and brain networks, an

X Xiwen Fan

Human iPSCs and iPSC-Derived Endothelial Cells from PAD Patients and Healthy Donors Exhibit Comparable Characteristics and Potency: Implications for Autologous Cell Therapy in Peripheral Artery Disease

bioRxiv [Preprint]. 2026 Sep 7:2026.09.04.749119. doi: 10.64898/2026.09.04.749119.ABSTRACTBACKGROUND: Peripheral artery disease (PAD) can lead to amputation in advanced cases, making cell therapy using human induced pluripotent stem cells (hiPSCs) a promising therapeutic option. hiPSC-derived endoth

J Jung Yoon Bae

Cuproptosis-associated genes DLD, ULK2, CCL8, and CCS link metabolic and immunological dysfunction in Parkinson's disease: a multi-omics study

Front Immunol. 2026 Sep 16;17:1813166. doi: 10.3389/fimmu.2026.1813166. eCollection 2026.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disorder whose pathogenesis involves complex interactions between metabolic dysfunction and neuroinflammation. The role of cuproptosis, a newly

J Jing Wang

Hypertension is associated with better brain health outcomes in older-age asymptomatic carotid disease populations - A Multi-Cohort Study

Res Sq [Preprint]. 2026 Sep 10:rs.3.rs-10731777. doi: 10.21203/rs.3.rs-10731777/v1.ABSTRACTBACKGROUND: Blood pressure (BP) management is highly relevant for cardiovascular and brain health outcomes. Although clinical guidelines are trending towards increasingly strict BP control, some discordant res

C Craig Weinkauf

Self-supervised plasma proteomic representations for prospective disease prediction across varying protein availability

medRxiv [Preprint]. 2026 Sep 12:2026.09.10.26362789. doi: 10.64898/2026.09.10.26362789.ABSTRACTLarge-scale plasma proteomics offers opportunities to characterize disease susceptibility and improve prospective risk prediction, but transferring proteomic predictors across datasets remains challenging

Y Yonghyun Nam

Prediction of Type 2 Diabetes using genomics and proteomics: the HUNT Study (ProtRS for T2D)

medRxiv [Preprint]. 2026 Sep 8:2026.09.06.26362374. doi: 10.64898/2026.09.06.26362374.ABSTRACTType 2 diabetes (T2D) is a multifactorial metabolic disorder with an increasing global prevalence and significant health burdens. Early identification of individuals at high risk is crucial for timely inter

F Fikria Karinanur

Circulating Proteins as Predictors of Improvement in Physical Function in Hospitalized Older Adults with Geriatric Syndromes: Findings from the REHAB-HF Trial

medRxiv [Preprint]. 2026 Sep 23:2026.09.22.26363692. doi: 10.64898/2026.09.22.26363692.ABSTRACTINTRODUCTION: Circulating proteins may augment prognostic scores and provide mechanistic insights for cardiovascular disease. Their role for adding precision to predicting response to therapeutic exercise

A Abdulla A Damluji

Proteomic and Kinetic Analyses Reveal Discordant Apolipoprotein Turnover and Support a Revised Model of Human Lipoprotein(a) Metabolism

bioRxiv [Preprint]. 2026 Sep 8:2026.09.04.749550. doi: 10.64898/2026.09.04.749550.ABSTRACTLipoprotein(a) [Lp(a)] is a causal risk factor for atherosclerotic cardiovascular disease composed of apolipoprotein(a) [APO(a)] covalently linked to apolipoprotein B100 (APOB). Although plasma Lp(a) concentrat

T Tiffany Thomas

Physiological Aging and Cardiovascular Disease Distinctly Remodel the Human Cardiac Lymphatic Endothelium

bioRxiv [Preprint]. 2026 Sep 25:2026.09.22.750171. doi: 10.64898/2026.09.22.750171.ABSTRACTAIMS: Cardiac lymphatic endothelial cells (LECs) regulate tissue homeostasis, immune trafficking, and remodeling, but how human cardiac LEC heterogeneity changes with physiological aging and cardiovascular dis

H Haotian Chen

Lactate Receptor Activation Alleviates Senescence and Preserves Homeostasis of Aged Arteries

bioRxiv [Preprint]. 2026 Sep 25:2026.09.20.753049. doi: 10.64898/2026.09.20.753049.ABSTRACTArteries are among the first tissues to exhibit age-related dysfunction, yet the metabolic mechanisms driving vascular senescence remain poorly understood. Here, analysis of human aortic transcriptomic data id

Y Yulun Wu

Variant-Specific Rewiring of Lysosomal Positioning by STARD9 Produces Opposite Cholesterol Trafficking Outcomes

bioRxiv [Preprint]. 2026 Sep 26:2026.09.25.754437. doi: 10.64898/2026.09.25.754437.ABSTRACTResidual cardiovascular risk persists despite lipid-lowering therapy, independent of LDL and Lp(a), reflecting cholesterol dysregulation. We identify STARD9, a lysosomal cholesterol-sensing kinesin, as a causa

M Mehdi Dianatpour

Exogenous L6 myotube mitochondrial transplantation attenuates hypertrophy and elicits a unique proteomic signature in phenylephrine-treated H9C2 cardiomyocytes

bioRxiv [Preprint]. 2026 Sep 22:2026.09.21.753229. doi: 10.64898/2026.09.21.753229.ABSTRACTMitochondrial transplantation has recently emerged as an alternative treatment for cardiovascular disease (CVD), aimed at increasing mitochondrial number and improving mitochondrial function. Though mitochondr

N Nicholas J Kontos

Single-cell transcriptomics reveals cell-type-specific circadian rhythms and their disruption by acute misalignment in mouse aorta

bioRxiv [Preprint]. 2026 Sep 21:2026.09.03.749170. doi: 10.64898/2026.09.03.749170.ABSTRACTThe circadian molecular clock is a 24-hour cellular timekeeper that influences many features of cardiovascular function. Disruption of the circadian clock via misalignment with the light-dark cycle is associat

B Benjamin J Auerbach

Robotic Training and Neural Reorganization in Stroke: A Systematic Review

F1000Res. 2026 May 19;15:762. doi: 10.12688/f1000research.180596.1. eCollection 2026.ABSTRACTINTRODUCTION: Stroke is a primary contributor to global adult morbidity, frequently resulting in debilitating gait disturbances that impede independence. While standard neurorehabilitation remains essential,

I Iyyappan Manickavasagam

Beyond the Threshold: Continuous Creatinine Change and Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke

Stroke. 2026 Oct 1. doi: 10.1161/STROKEAHA.126.056847. Online ahead of print.ABSTRACTBACKGROUND: Contrast-associated acute kidney injury (CA-AKI) after endovascular thrombectomy (EVT) worsens outcomes in acute ischemic stroke, but threshold-based definitions do not capture prognostic information fro

G Ghil Schwarz

Acetyltransferase MOF Regulates Macrophage Inflammation in Abdominal Aortic Aneurysms

Circ Res. 2026 Oct 1. doi: 10.1161/CIRCRESAHA.126.329212. Online ahead of print.ABSTRACTBACKGROUND: Abdominal aortic aneurysms (AAAs) are a life-threatening cardiovascular disease for which there is a lack of therapy preventing aortic rupture. During AAA formation, pathological vascular remodeling i

X Xiaobing He

Impact of Undertreated Antithrombotic Therapy on Adverse Patient Outcomes: A Scientific Statement From the American Heart Association

Circulation. 2026 Oct 1. doi: 10.1161/CIR.0000000000001474. Online ahead of print.ABSTRACTAntithrombotic therapy undertreatment includes omission, nonadherence, underdosing, and clinical circumstances that result in subtherapeutic antithrombotic levels. Antithrombotic undertreatment has profound imp

K Kelly Rudd