Early introduction of mepolizumab for refractory coronary vasospasm and severe acute coronary syndrome secondary to eosinophilic granulomatosis with polyangiitis: a case report

No abstractClin Exp Rheumatol. 2026 Apr;44(4):857-858. doi: 10.55563/clinexprheumatol/58s5h9. Epub 2026 Apr 22.NO ABSTRACTPMID:42018351 | DOI:10.55563/clinexprheumatol/58s5h9

P Paola Tomietto

US Trends in Prescribing Nonstatin Lipid-Lowering Therapy, 2019-2024

No abstractJAMA Cardiol. 2026 Apr 22. doi: 10.1001/jamacardio.2026.0844. Online ahead of print.NO ABSTRACTPMID:42018292 | DOI:10.1001/jamacardio.2026.0844

S Semenawit Burka

Oxidative stress and cardiovascular risk related to urinary metal(loid) levels in a pediatric population

Environ Geochem Health. 2026 Apr 22;48(7):311. doi: 10.1007/s10653-026-03190-z.ABSTRACTCardiovascular diseases are the leading cause of death, and reducing them requires identifying risk factors, among which exposure to environmental pollutants is well documented. Metal(loid) exposure is related to

M Manolo Ortega-Romero

Mitochondrial dysfunction in endothelial senescence: implications for vascular remodeling and therapeutic strategies

Arch Pharm Res. 2026 Apr 22. doi: 10.1007/s12272-026-01614-z. Online ahead of print.ABSTRACTVascular remodeling (VR) is a structural and functional adaptation of the vessel wall to hemodynamic, metabolic, and inflammatory stress. When persistent and dysregulated, it contributes to the progression of

W Wen Li

Impact of Aspirin on Primary Prevention of Cardiovascular Events in Patients with Elevated Lipoprotein(a): A Systematic Review and Meta-analysis

Am J Cardiovasc Drugs. 2026 Apr 22. doi: 10.1007/s40256-026-00795-8. Online ahead of print.ABSTRACTINTRODUCTION: Elevated lipoprotein(a) (Lp(a)) and Lp(a)-raising genetic variants (e.g. rs3798220) are independent cardiovascular risk factors lacking preventive strategies. Given the prothrombotic prop

D Daniel Caldeira

Dexmedetomidine Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting DNMT3B-Mediated Hypermethylation of the KLF4 Promoter

No abstractCardiovasc Drugs Ther. 2026 Mar 10. doi: 10.1007/s10557-026-07869-4. Online ahead of print.NO ABSTRACTPMID:42018100 | DOI:10.1007/s10557-026-07869-4

X XinJing Chen

Advancements in mapping, cardiac imaging, and ablation techniques for the management of ventricular tachycardias

J Interv Card Electrophysiol. 2026 Apr 22. doi: 10.1007/s10840-026-02336-4. Online ahead of print.ABSTRACTVentricular tachycardias represent a complex clinical challenge, particularly due to the intricate arrhythmic circuits and diverse substrates found in ischemic and non-ischemic cardiomyopathies.

A Alejandro Sanchez-Nadales

Diagnostic performance of native T1 in grading histologically proven myocardial glycosphingolipid accumulation in Fabry disease

Insights Imaging. 2026 Apr 22;17(1):114. doi: 10.1186/s13244-026-02262-z.ABSTRACTOBJECTIVE: Fabry disease cardiomyopathy (FD-CM) is a genetic disorder induced by glycosphingolipid accumulation (GSL-A) in cardiac cells, resulting in left ventricular hypertrophy (LVH) and contractile impairment. Nativ

N Nicola Galea

The Role of Metal Ions in Mitochondria: From Energy Metabolism to Cell Destiny

Biol Trace Elem Res. 2026 Apr 22. doi: 10.1007/s12011-026-05112-7. Online ahead of print.ABSTRACTMetal ions are indispensable for cellular life, as they maintain mitochondrial ion homeostasis and function as essential cofactors in mitochondrial energy metabolism, particularly within the electron tra

C Chunlan Li

Quantum-inspired cardiac risk assessment using hybrid CSAGGO-Q-SpinalNet algorithm for precise heart disease prediction

J Xray Sci Technol. 2026 Apr 22:8953996261439087. doi: 10.1177/08953996261439087. Online ahead of print.ABSTRACTCardiovascular disease remains the leading cause of mortality globally, with escalating risk factors and increasing pressure on the healthcare system. Despite the critical importance of ea

W W Ancy Breen

Neuroimmune pathways linking sleep disturbance to persistent pain after injury are mitigated by exercise

Pain. 2026 Apr 17. doi: 10.1097/j.pain.0000000000003978. Online ahead of print.ABSTRACTSleep and physical activity are modifiable behaviours linked to pain. Sleep disturbance often co-occurs with persistent pain and may contribute to its development. Exercise is a first-line treatment for chronic pa

D David M Klyne

Focal and Diffuse Coronary Artery Disease Patterns and Placebo-Controlled Angina Relief With Percuatenous Coronary Intervention: ORBITA-2

J Am Coll Cardiol. 2026 Apr 22:S0735-1097(26)05732-3. doi: 10.1016/j.jacc.2026.02.5126. Online ahead of print.ABSTRACTBACKGROUND: Unblinded studies have demonstrated superior procedural and clinical outcomes of percutaneous coronary intervention (PCI) in focal compared with diffuse coronary artery d

K Kayla Chiew

Midlife Cardiorespiratory Fitness and Healthy Aging: An Observational Cohort Study

J Am Coll Cardiol. 2026 Apr 13:S0735-1097(26)05723-2. doi: 10.1016/j.jacc.2026.02.5122. Online ahead of print.ABSTRACTBACKGROUND: Higher cardiorespiratory fitness (CRF) is associated with a lower risk for chronic disease and death, but its relation to healthy aging more broadly remains understudied.

C Clare Meernik

Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study

J Am Coll Cardiol. 2026 Apr 13:S0735-1097(26)05561-0. doi: 10.1016/j.jacc.2026.02.5093. Online ahead of print.ABSTRACTBACKGROUND: Excess adiposity, most commonly indexed through body mass index (BMI), is strongly associated with the development of heart failure (HF). Weight loss therapies improve ou

N Nicholas Sunderland

Culture-Negative Infective Endocarditis: The Target Is in the Crosshairs

No abstractJ Am Coll Cardiol. 2026 Apr 22:S0735-1097(26)05884-5. doi: 10.1016/j.jacc.2026.03.050. Online ahead of print.NO ABSTRACTPMID:42017881 | DOI:10.1016/j.jacc.2026.03.050

K Khalid Abu-Zeinah

Heart Failure Among 173,000 Community-Dwelling Participants From 25 Low-, Middle-, and High-Income Countries in the PURE Study

J Am Coll Cardiol. 2026 Apr 15:S0735-1097(26)05510-5. doi: 10.1016/j.jacc.2026.02.5085. Online ahead of print.ABSTRACTBACKGROUND: Most population studies examining heart failure (HF) have been conducted in Western high-income countries (HICs), with limited comparable data from lower-income settings.

I Isabelle Johansson Bartolini

Oral PCSK9 Inhibitor Enlicitide Versus Oral Nonstatin Therapies: A Phase 3 Randomized Clinical Trial

J Am Coll Cardiol. 2026 Mar 30:S0735-1097(26)05832-8. doi: 10.1016/j.jacc.2026.03.036. Online ahead of print.ABSTRACTBACKGROUND: Many adults fail to achieve guideline-directed low-density lipoprotein cholesterol (LDL-C) goals on statin monotherapy, requiring additional nonstatin lipid-lowering medic

A Alberico L Catapano

Assessing the Impact of Extreme Climate Events on Cardiovascular Disease in 157 Chinese Cities (2015-2020): A Spatial and Causal Analysis

Am J Prev Med. 2028 Feb 29:108280. doi: 10.1016/j.amepre.2026.108280. Online ahead of print.ABSTRACTINTRODUCTION: Extreme climate events worsen cardiovascular disease burden, exacerbated by rapid aging. Prior studies have linked extreme climate events to cardiovascular disease mortality but have lac

L Linjiang Wei

Effectiveness of Rhythm Control of Atrial Fibrillation in Moderate-to-Severe or Severe Secondary Tricuspid Regurgitation

JACC Cardiovasc Imaging. 2026 Apr 21:S1936-878X(26)00150-6. doi: 10.1016/j.jcmg.2026.03.006. Online ahead of print.ABSTRACTBACKGROUND: Secondary tricuspid regurgitation (STR) is heterogeneous and associated with increased morbidity and mortality, but there remains limited evidence on the optimal man

J Jwan A Naser

Syncopal Episodes in Coved ST-Segment Elevation and T-Wave Inversion in Anterior Leads

JACC Case Rep. 2026 Apr 22:108014. doi: 10.1016/j.jaccas.2026.108014. Online ahead of print.ABSTRACTCASE SUMMARY: We describe the case of an 88-year-old male patient referred to our cardiology outpatient clinic because of recent and recurrent syncopal episodes, often preceded by palpitations. At cli

S Saverio Tremamunno

Life Course Cumulative BMI Burden From Childhood to Adulthood and Risk of Metabolic Multimorbidity: A 36-Year Prospective Cohort Study

Diabetes Care. 2026 Apr 22:dc252889. doi: 10.2337/dc25-2889. Online ahead of print.ABSTRACTOBJECTIVE: To examine the associations between cumulative BMI burden from childhood to adulthood and the risk of adult metabolic multimorbidity.RESEARCH DESIGN AND METHODS: This prospective cohort study used d

T Tongshuai Guo

Natural polysaccharides as multifunctional regulators of energy metabolism: mechanisms, structure-activity relationships, and cross-disease applications

Crit Rev Food Sci Nutr. 2026 Apr 22:1-30. doi: 10.1080/10408398.2026.2660145. Online ahead of print.ABSTRACTDysregulated energy metabolism is a common pathological feature of various chronic diseases, including metabolic syndrome, neurodegenerative disorders, cancers, and cardiovascular diseases. Na

S Song Wei

Prognostic value of multi-marker stress echocardiography

Future Cardiol. 2026 Apr 22:1-11. doi: 10.1080/14796678.2026.2659089. Online ahead of print.ABSTRACTStress echocardiography (SE) has evolved beyond its traditional role of detecting coronary artery disease (CAD) through a single marker-regional wall motion abnormality (RWMA). This conventional appro

E Eugenio Picano

PD-L1 in ICI Myocarditis: When the Immune Brake Fails

No abstractJACC CardioOncol. 2026 Apr;8(2):181-184. doi: 10.1016/j.jaccao.2026.03.003.NO ABSTRACTPMID:42017568 | DOI:10.1016/j.jaccao.2026.03.003

A Adrian C Chen