A System Pharmacology Approach: Deciphering Atheroprotective Mechanisms of Yi-Mai Compound Through Integrative Analysis of UPLC-ESI-MS Profiling, Network Targeting, and Molecular Docking

Biomed Chromatogr. 2026 Jan;40(1):e70263. doi: 10.1002/bmc.70263.ABSTRACTYi-Mai compound (YMHJ), a traditional Chinese medicine formulation, has demonstrated therapeutic efficacy against atherosclerosis (AS) in clinical observational studies. To elucidate its underlying pharmacological mechanisms, t

M Min Xiong

Protocol for a randomized controlled trial for comparison of self- and balloon-expandable valves in patients with Ascending Aortic Dilation Undergoing Transcatheter Aortic Valve Replacement (AAD-CHOICE)

Trials. 2025 Nov 28. doi: 10.1186/s13063-025-09233-7. Online ahead of print.ABSTRACTBACKGROUND: Self-expandable valves (SEVs) and balloon-expandable valves (BEVs) are the most widely used transcatheter heart valves. In patients with ascending aortic dilation (AAD) who undergo transcatheter aortic va

K Kang An

Association of body roundness index with cardiovascular disease in early Cardiovascular-Kidney-Metabolic syndrome stage 0-3: mediation by the triglyceride-glucose index in a national cohort study

Diabetol Metab Syndr. 2025 Nov 28;17(1):443. doi: 10.1186/s13098-025-02007-w.ABSTRACTBACKGROUND: Cardiovascular-Kidney-Metabolic (CKM) syndrome, encompassing metabolic dysfunction, chronic kidney disease, and cardiovascular disease (CVD), represents a growing global health challenge. Body Roundness

J Jiamiao Cai

Chronic papillary muscle rupture, a case report

J Cardiothorac Surg. 2025 Nov 28;20(1):444. doi: 10.1186/s13019-025-03689-z.ABSTRACTBACKGROUND: Papillary muscle rupture is a rare and potentially fatal complication of acute myocardial ischemia, which typically results in acute severe mitral regurgitation and cardiogenic shock. Due to the urgent ne

N Napat Pruekprasert