Intra-aortic adrenaline titration during cardiac arrest

Scand J Trauma Resusc Emerg Med. 2026 Apr 15;34(1):71. doi: 10.1186/s13049-026-01609-1.ABSTRACTAdrenaline has been the principal vasoactive drug in cardiac arrest for decades. It reliably increases return of spontaneous circulation but has not shown a consistent improvement in long-term survival wit

J James E Manning

Sex Hormone Influences on Venous Thrombotic and Cardiovascular Risk

N Engl J Med. 2026 Apr 16;394(15):1514-1528. doi: 10.1056/NEJMra2202438.ABSTRACTThrombosis is a recognized complication of sex hormone therapy, which includes hormone replacement for deficiencies, contraceptive therapy, treatment of heavy menstrual bleeding, gender-affirming hormone therapy, suppres

L Leslie Skeith

Randomized Trial of Adjunctive Prednisolone for Kawasaki Disease

N Engl J Med. 2026 Apr 16;394(15):1480-1490. doi: 10.1056/NEJMoa2511478.ABSTRACTBACKGROUND: The effect of adjunctive glucocorticoids in the primary treatment of Kawasaki disease in unselected patients remains unknown.METHODS: In this multicenter, open-label, randomized, controlled trial in China, we

S Siyuan Lin

Asundexian for Secondary Stroke Prevention

N Engl J Med. 2026 Apr 16;394(15):1467-1479. doi: 10.1056/NEJMoa2513880.ABSTRACTBACKGROUND: Patients with noncardioembolic ischemic stroke or transient ischemic attack (TIA) are at risk for recurrent stroke. Low factor XI levels are associated with a reduced risk of ischemic stroke. Asundexian inhib

M Mukul Sharma