Major ECG abnormalities and risk of incident cardiovascular disease in people with HIV compared to people without HIV

AIDS. 2026 May 19. doi: 10.1097/QAD.0000000000004547. Online ahead of print.ABSTRACTOBJECTIVES: People with HIV (PWH) have an increased risk of cardiovascular disease (CVD). In the general population, major electrocardiographic (ECG) abnormalities have been associated with increased risk of incident

M Manon C Vanbellinghen

Pediatric Anesthesia Practice and Training in Ibero-America: A Web-Based Cross-Sectional Survey

Paediatr Anaesth. 2026 May 20. doi: 10.1002/pan.70221. Online ahead of print.ABSTRACTBACKGROUND: Pediatric anesthesia training varies widely across Ibero-America, and many anesthesiologists care for children without formal specialized preparation.AIMS: To describe training patterns, clinical exposur

J John Pirez

eGFR slope and risk of cardiovascular, kidney, and mortality outcomes in hypertension: a longitudinal cohort study

J Hypertens. 2026 Apr 15. doi: 10.1097/HJH.0000000000004324. Online ahead of print.ABSTRACTOBJECTIVE: : Evidence on the prognostic value of estimated glomerular filtration rate (eGFR) slope in Asian individuals with hypertension is limited. We examined associations of eGFR slope with cardiovascular

A Akira Oda

Lactate and lactylation: mechanisms, function, diseases, and therapeutic targets

Mol Biomed. 2026 May 20;7(1):71. doi: 10.1186/s43556-026-00472-x.ABSTRACTThe paradigm shift of lactate from a mere metabolic byproduct to a pleiotropic signaling molecule, coupled with the discovery of lactylation, provides a crucial framework for understanding how metabolic reprogramming drives sys

X Xiuping Wang

Platelet indices and incident CKD in high-risk individuals

Clin Exp Nephrol. 2026 May 20. doi: 10.1007/s10157-026-02886-x. Online ahead of print.ABSTRACTBACKGROUND: Platelet indices, including platelet distribution width (PDW) and mean platelet volume (MPV), reflect platelet activation and have been associated with kidney disease progression in various popu

K Kenichi Tanaka

Efficacy and Safety of Catheter Ablation for Atrial Arrhythmias in Solid Organ Transplant Recipients: A Single-Center Experience

Clin Cardiol. 2026 May;49(5):e70345. doi: 10.1002/clc.70345.ABSTRACTINTRODUCTION: Atrial arrhythmias are common among solid organ transplant recipients and independently associated with increased morbidity, mortality, and impaired graft survival. Pharmacological management is substantially limited b

P Piotr Gardziejczyk

Non-canonical PPARα Agonism by Arjunolic Acid Mitigates Cardiomyocyte PANoptosis Through a Novel PPARα/CRYAB/IKKα Axis During Pathological Cardiac Hypertrophy

Cardiovasc Toxicol. 2026 May 20;26(6):54. doi: 10.1007/s12012-026-10120-z.ABSTRACTPathological cardiac hypertrophy is manifested by downregulated PPARα driven metabolic dysregulation which culminates into cardiomyocyte apoptosis. Emerging evidences indicate that additional regulated cell death mecha

A Abhik Kar

Maraviroc Attenuates Neuronal Apoptosis by Inhibiting CCR5-Mediated Microglial Activation After Subarachnoid Hemorrhage

Neurochem Res. 2026 May 20;51(3):161. doi: 10.1007/s11064-026-04779-7.ABSTRACTSubarachnoid hemorrhage (SAH) triggers robust neuroinflammatory responses that contribute to secondary brain injury, with microglia acting as central mediators; however, the upstream regulators governing microglial activat

J Jiasen Ye

Niosomal Gallic Acid Attenuates Obesity-related Hepatic Steatosis Through Oxidative and Inflammatory Regulation With Associated Autophagy and Hedgehog Pathway Modulation

Appl Biochem Biotechnol. 2026 May 20. doi: 10.1007/s12010-026-05719-5. Online ahead of print.ABSTRACTObesity is an epidemic condition that is linked to several health issues, including metabolic disorders, diabetes mellitus, and cardiovascular disease. The anti-inflammatory and antioxidant qualities

M Mahran Mohamed Abd El-Emam

The Integrated Stress Response Protein, eIF2α, Modulates UPRmt Signaling and Cell Death in Doxorubicin Treated Human Cardiac Cells

Cardiovasc Toxicol. 2026 May 20;26(6):53. doi: 10.1007/s12012-026-10124-9.ABSTRACTDoxorubicin (DOX), is an indispensable first-line chemotherapeutic. Despite this first-line indication, clinical use of DOX is limited by severe, off-target, and often irreversible cardiotoxicity. DOX induces cytotoxic

K Kienan P O'Dwyer

Severe mesangiolysis with prominent microaneurysm formation following total body irradiation conditioning for bone marrow transplantation

CEN Case Rep. 2026 May 20;15(3):92. doi: 10.1007/s13730-026-01130-5.ABSTRACTPatients who undergo hematopoietic stem cell transplantation (HSCT) face a high risk of acute kidney injury (AKI), which significantly increases the likelihood of developing chronic kidney disease (CKD). Proteinuria is also

Y Yosuke Nakagawa

Mild hypothermia inhibits the inflammatory response and microglial M1 polarization in ischemic stroke via the EFNB2/EphB4 pathway

Metab Brain Dis. 2026 May 20;41(1):110. doi: 10.1007/s11011-026-01833-9.ABSTRACTBACKGROUND: Mild hypothermia (MH) has been reported to ameliorate cerebral damage and neurofunctional deficits in ischemic stroke, but its molecular mechanisms remain unclear. This study focuses on exploring the neuropro

G Ganghua Feng

Ten-year clinical course of familial lecithin-cholesterol acyltransferase deficiency caused by Cys74Tyr mutation leading to dialysis and multiple systemic complications: a case report

CEN Case Rep. 2026 May 20;15(3):91. doi: 10.1007/s13730-026-01128-z.ABSTRACTFamilial lecithin-cholesterol acyltransferase deficiency (FLD) is a rare hereditary disorder. In FLD, a clinical triad of corneal opacity, anemia, and proteinuria typically precedes progressive renal dysfunction. Although ea

T Takuya Yamazaki

The Molecular Mechanism of LncRNA LUCAT1 Regulating HSPB8 Expression via miR-337-3p in Modulating Neurological Damage After Cerebral Infarction

Neurochem Res. 2026 May 20;51(3):163. doi: 10.1007/s11064-026-04781-z.ABSTRACTThis study aims to investigate the role of the lncRNA LUCAT1 in cerebral infarction-induced neurological damage. In vitro experiments employed N2a cells to establish an OGD/R model, while in vivo experiments utilized male

L Lei Lei

Early post-IVIG serum IgG concentration does not explain IVIG non-response in Kawasaki disease

Eur J Pediatr. 2026 May 20;185(6):418. doi: 10.1007/s00431-026-07087-y.ABSTRACTIntravenous immunoglobulin (IVIG) at 2 g/kg is the standard first-line therapy for acute Kawasaki disease (KD), yet a subset of patients remains febrile after treatment. Whether IVIG non-response is primarily explained by

I Ikuo Hashimoto

The impact of BMI on mechanical thrombectomy outcomes, insights from a comprehensive stroke center

Neurosurg Rev. 2026 May 20;49(1):412. doi: 10.1007/s10143-026-04324-8.ABSTRACTIdentifying predictors of outcomes following mechanical thrombectomy (MT) for stroke is crucial for selecting patients most likely to benefit from the treatment as well as guiding prognostication efforts. When it comes to

V Victor Gabriel El-Hajj

Reducing descending aortic tortuosity improves thoracic endovascular aortic repair outcomes in type B aortic dissection: from a hemodynamic perspective

Biomech Model Mechanobiol. 2026 May 20;25(3):45. doi: 10.1007/s10237-026-02066-6.ABSTRACTFor patients with tortuous descending aortas undergoing thoracic endovascular aortic repair (TEVAR), reducing tortuosity may optimize stent-wall conformity and improve surgical outcomes, but its necessity remain

Y Yue Che

Neuroprotective effects of myrtenol against brain injury following isoproterenol-induced myocardial infarction in male rats

Metab Brain Dis. 2026 May 20;41(1):108. doi: 10.1007/s11011-026-01865-1.ABSTRACTMyocardial infarction (MI) induces brain injury. Myrtenol has antioxidant and anti-inflammatory effects. This study investigated the neuroprotective effect of myrtenol following myocardial infarction induced by isoproter

N Nima Rahimi Petrudi

Genistein-3'-sodium sulfonate improves neuroinflammation, blood-brain barrier function, and microglial activation after chronic cerebral hypoperfusion by regulating TGR5

Metab Brain Dis. 2026 May 20;41(1):109. doi: 10.1007/s11011-026-01867-z.ABSTRACTThis study investigated the effects of genistein-3'-sodium sulfonate (GSS) on chronic cerebral hypoperfusion (CCH) and the involvement of Takeda G-protein-coupled receptor 5 (TGR5) (also known as GPBAR1 (G protein-couple

M Mengyao Fan

Impact of different exercise modalities on blood pressure in patients with nocturnal hypertension

J Hypertens. 2026 Apr 15. doi: 10.1097/HJH.0000000000004317. Online ahead of print.ABSTRACTNocturnal hypertension is the blood pressure (BP) phenotype most strongly associated with cardiovascular morbidity and mortality, yet no specific therapeutic strategy has been established. Physical activity ef

M Matías Santa Maria

Association between individual cerebral small vessel disease MRI markers and neuropsychological performance in amnestic mild cognitive impairment: an exploratory study

J Neurol. 2026 May 20;273(6):322. doi: 10.1007/s00415-026-13861-7.ABSTRACTBACKGROUND AND PURPOSE: The association between individual SVD MRI markers and specific cognitive function remains unclear. This study investigated the association between SVD MRI markers and neuropsychological assessments in

K Kana Matsuda

CSF Biomarker Profile of Cerebral Amyloid Angiopathy: Diagnostic Performance and Imaging Correlates in a Hospital-Based Neurology Cohort

Eur J Neurol. 2026 May;33(5):e70613. doi: 10.1111/ene.70613.ABSTRACTBACKGROUND: Cerebral amyloid angiopathy (CAA) frequently co-occurs with Alzheimer's disease (AD), complicating diagnosis in patients with cognitive impairment. The CSF biomarker profile of CAA remains poorly understood, particularly

A Aida Fernández-Lebrero

Intracellular NAD+ Depletion Increases Prostanoid Production via p38/COX2 Signalling in FK866-Induced Senescent Human Umbilical Vein Endothelial Cells

J Cell Mol Med. 2026 May;30(10):e71187. doi: 10.1111/jcmm.71187.ABSTRACTVascular endothelial cells maintain vascular homeostasis by releasing mediators with vasoconstrictive and vasorelaxant effects. Prostanoids are bioactive substances synthesised by cyclooxygenase2 (COX2); they preserve vascular f

N Natsuko Kitajima

Candidate Mechanisms of Cerebral Ischemia/Hypoxia Tolerance: Insights from Hibernating Rodents

Neurochem Res. 2026 May 20;51(3):165. doi: 10.1007/s11064-026-04787-7.ABSTRACTCerebral ischemia/hypoxia constitutes a central pathological process in ischemic stroke and a range of neurological disorders, yet effective and safe neuroprotective strategies remain scarce in clinical practice. Hibernati

R Ruixin Li