Acute coronary syndrome is associated with acute kidney injury on admission but not during hospital stay

Ren Fail. 2026 Dec;48(1):2666698. doi: 10.1080/0886022X.2026.2666698. Epub 2026 May 6.ABSTRACTAcute kidney injury (AKI) is common in patients with acute coronary syndrome (ACS). However, understanding its prevalence, risk factors and prognosis remains incomplete. We identified 21328 patients admitte

C Cheuk-Chun Szeto

Perceptions, Knowledge and Culinary Use of Legumes in Australia: A Convenience Sample Analysis

J Hum Nutr Diet. 2026 Jun;39(3):e70265. doi: 10.1111/jhn.70265.ABSTRACTBACKGROUND: Legumes, a staple food from the Leguminosae family, are widely consumed and deliver key food components and nutrients, including dietary fibre and plant protein. Regular consumption is associated with improved health

C Cassandra J Nikodijevic

GLP-1 Receptor Agonist Therapy and Cardiorenal Outcomes in Type 1 Diabetes: A Propensity-Matched Real-World Analysis

Diabetes Obes Metab. 2026 May 6. doi: 10.1111/dom.70841. Online ahead of print.ABSTRACTAIMS: Evidence on cardiovascular/renal outcomes associated with GLP-1-based therapies in type 1 diabetes (T1D) is limited. We examined the effects of GLP-1-based therapy on major clinical outcomes and safety, incl

A Anastasios Tentolouris

Suboptimal LDL-Cholesterol Control Under the 2019 ESC/EAS Dyslipidemia Guidelines: Results From the Nationwide TEMD-2 Study in Type 2 Diabetes

Diabetes Obes Metab. 2026 May 6. doi: 10.1111/dom.70806. Online ahead of print.ABSTRACTBACKGROUND: Lowering LDL cholesterol (LDL-C) decreases cardiovascular risk substantially in type 2 diabetes. Despite stricter LDL-cholesterol targets in the 2019 ESC/EAS dyslipidemia guidelines, target achievement

O Ozge Telci Caklili

A network medicine framework for multi-modal data integration in therapeutic target discovery

Commun Chem. 2026 May 6. doi: 10.1038/s42004-026-02049-9. Online ahead of print.ABSTRACTThe high cost and attrition rate of drug development underscore the need for more effective strategies for therapeutic target discovery. Here, we present a network medicine-based machine learning framework that i

G Greta Baltušytė

Expanding the human proteome with microproteins and peptideins

Nature. 2026 May 6. doi: 10.1038/s41586-026-10459-x. Online ahead of print.ABSTRACTA major scientific drive is to characterize the protein-coding genome, which is a primary basis for studying human health. But the fundamental question remains of what has been missed in previous analyses. Over the pa

E Eric W Deutsch

Uncovering the similarities of lipidome-wide markers of carotid artery plaque and metabolic dysfunction-associated fatty liver disease: the Young Finns study

Sci Rep. 2026 May 6. doi: 10.1038/s41598-026-51430-0. Online ahead of print.ABSTRACTMetabolic dysfunction-associated fatty liver disease (MAFLD) and carotid artery plaque (CAP) are both linked to circulatory lipid and lipoprotein metabolism. However, the shared lipidome-wide mechanisms underlying th

H Haniyeh Danest Doost

Longitudinal assessment of thrombin generation using calibrated automated thrombography in patients with continuous-flow left ventricular assist devices over a five-year period

Sci Rep. 2026 May 6. doi: 10.1038/s41598-026-51694-6. Online ahead of print.ABSTRACTDespite improved survival, patients with advanced heart failure receiving long-term left ventricular assist device (LVAD) support remain at risk of serious complications, including pump thrombosis, ischemic stroke, a

A Agnieszka Kuczaj

Integration of lung function in allostatic load scoring and its impact on mortality prediction

Sci Rep. 2026 May 6. doi: 10.1038/s41598-026-48880-x. Online ahead of print.ABSTRACTAllostatic load refers to the physiological "wear and tear" that results from adaptation to stressors over the lifespan. In this study, we integrated lung function (LF) parameters into the calculation of the allostat

M Mohammad Azizzadeh

Coronary angiography/revascularization status and 1-year cardiovascular outcomes in survivors of out-of-hospital cardiac arrest

Sci Rep. 2026 May 6. doi: 10.1038/s41598-026-52089-3. Online ahead of print.ABSTRACTWhile neurologic outcomes after out-of-hospital cardiac arrest (OHCA) have been extensively studied, long-term cardiovascular outcomes remain underexplored. Coronary angiography (CAG) and revascularization status may

S Sang-Min Kim

Circulating levels of sFlt-1 and AT1-AA in women with prior preeclampsia: a 10-year postpartum cross-sectional analysis (PERLA-Brazil study)

Sci Rep. 2026 May 6. doi: 10.1038/s41598-026-50409-1. Online ahead of print.ABSTRACTThis study investigated whether soluble fms-like tyrosine kinase-1 (sFlt-1) and angiotensin II type 1 receptor autoantibodies (AT1-AA) - key mediators of preeclampsia (PE) pathophysiology - remain elevated ten years

T Thaíse Emilia Moreira da Silva

Association of Bone Mass, Falls, and Vertebral Fractures in Older Patients on Hemodialysis: The Role of Comprehensive Geriatric Assessment

J Gen Intern Med. 2026 May 6. doi: 10.1007/s11606-026-10398-3. Online ahead of print.ABSTRACTBACKGROUND: End-stage renal disease (ESRD) requiring hemodialysis (HD) disproportionately affects older adults, who face increased risks of falls and fractures due to age-related changes, renal osteodystroph

S Suzan Abou-Raya

Deciphering Crossed Cerebellar Diaschisis in Patients with Large-Vessel Occlusion Acute Ischemic Stroke using BOLD Cerebrovascular Reactivity

Cerebellum. 2026 May 7;25(3):72. doi: 10.1007/s12311-026-02014-1.ABSTRACTCrossed cerebellar diaschisis (CCD) is characterized by reduced perfusion and metabolism in the cerebellar hemisphere contralateral to a supratentorial lesion. In large-vessel occlusion acute ischemic stroke (LVO-AIS), CCD may

J Jacopo Bellomo

Should Incretin Agonist-Based Brugs be Considered for First Line Antihypertensive Therapy?

Curr Hypertens Rep. 2026 May 7;28(1):25. doi: 10.1007/s11906-026-01374-7.ABSTRACTPURPOSE OF REVIEW: This review evaluates the antihypertensive potential of next-generation incretin-based therapies, including GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists. It examines their effects on b

D Dominik Kylies

Detailed evaluation of the long-term outcomes of repeat stereotactic radiosurgery for brain arteriovenous malformations: A single-center retrospective study

Neurosurg Rev. 2026 May 7;49(1):395. doi: 10.1007/s10143-026-04303-z.ABSTRACTRepeat stereotactic radiosurgery (SRS) is a treatment option for residual brain arteriovenous malformations (AVMs) following incomplete response to an initial SRS, and this study aimed to clarify the long-term outcomes. Pat

T Takeru Hirata

Outcome and epilepsy following neonatal stroke in the Italian Registry of Infantile Thrombosis

Eur J Pediatr. 2026 May 7;185(6):352. doi: 10.1007/s00431-026-06912-8.ABSTRACTThe perinatal period is a high-risk time for stroke, with possible lifelong effects. We aimed at identifying factors associated with long-term neurological outcomes and post-stroke epilepsy in patients with neonatal arteri

S Stefano Sartori

Effects of hypoxia-inducible factor prolyl hydroxylase inhibitors on lipid profiles in patients with chronic kidney disease: a systematic review and meta-analysis

Eur J Clin Pharmacol. 2026 May 7;82(6):142. doi: 10.1007/s00228-026-04072-0.ABSTRACTBACKGROUND: Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are novel oral agents for treating anemia in chronic kidney disease (CKD), with potential effects on lipid modulation. We aimed to systema

Y Yun-Hui Huang

Directional Atherectomy Versus Plain Old Balloon Angioplasty for Vessel Preparation Before Drug-Coated Balloon Treatment in Moderate-to-Severe Calcified Lesions

Cardiovasc Intervent Radiol. 2026 May 6. doi: 10.1007/s00270-026-04463-x. Online ahead of print.ABSTRACTPURPOSE: This study aimed to compare directional atherectomy (DA) and plain old balloon angioplasty (POBA) for vessel preparation before drug-coated balloon (DCB) therapy in moderately to severely

B Bing Wang

The association of time-restricted eating and indices of organ-specific aging in relation to metabolic health and obesity

NPJ Sci Food. 2026 May 6. doi: 10.1038/s41538-026-00862-z. Online ahead of print.ABSTRACTThis cross-sectional study explored how time-restricted eating (TRE) interacts with metabolic health and obesity (MH&O) in relation to biological age indices of different organs. Data from the National Health an

L Liuzexuan Sheng

Vascular Ehlers-Danlos Syndrome Diagnosed after Cerebral Infarction with a Subarachnoid Hemorrhage

Intern Med. 2026;65(9):1296-1301. doi: 10.2169/internalmedicine.6033-25. Epub 2026 May 1.ABSTRACTVascular Ehlers-Danlos syndrome (vEDS) is a rare genetic disorder characterized by either an arterial rupture or organ perforation, which is challenging to diagnose prior to the onset of major complicati

T Tomohisa Yamaguchi

Lipoprotein(a) Distribution and Cardiovascular Risk in Japan: Insights from a Multi-center LEAP Study

J Atheroscler Thromb. 2026 May 2. doi: 10.5551/jat.66185. Online ahead of print.ABSTRACTAIM: Although lipoprotein(a) [Lp(a)] is recognized as an independent risk factor for cardiovascular disease (CVD), its distribution and risk thresholds in the Japanese population remain unclear. This study aimed

T Tomoaki Yamada

Pilot Study of the Composite Graft Constructed from Two Saphenous Veins with a Single Inflow Source in Coronary Artery Bypass Grafting with Atherosclerotic Ascending Aorta

J Nippon Med Sch. 2026;93(2):115-121. doi: 10.1272/jnms.JNMS.2026_93-205.ABSTRACTBACKGROUND: This pilot study aimed to evaluate early outcomes of a composite graft constructed from two saphenous veins (SVs) with a single inflow source in coronary artery bypass grafting (CABG) for patients with an at

M Makoto Shirakawa

North-South Disparities in Multimorbidity Revealed by Association Rule and Sequential Pattern Mining: Evidence from the China National Health Survey (CNHS)

J Epidemiol. 2026 May 2. doi: 10.2188/jea.JE20260009. Online ahead of print.ABSTRACTBackgroundNorth-south differences in context and lifestyle may shape multimorbidity patterns in China. We compared multimorbidity between two northern (Liaoning, Jilin) and two southern (Guangdong, Jiangsu) CNHS prov

Z Zhili Chen

Vitamin D and Body Mass Index/Obesity in Postmenopausal Women: A Cross-Sectional Study With Analysis of the Atherogenic Index of Plasma as a Mediator

J Obstet Gynaecol Res. 2026 May;52(5):e70325. doi: 10.1111/jog.70325.ABSTRACTOBJECTIVE: To investigate the link between serum 25-hydroxyvitamin D [25(OH)D] and obesity in postmenopausal women, and to evaluate the potential mediating effect of the atherogenic index of plasma (AIP).METHODS: In this cr

X Xuanping Lu