Coffee as a polypharmacological modulator of mitochondrial health: from molecular mechanisms to translational implications

J Transl Med. 2026 Jul 17. doi: 10.1186/s12967-026-08662-5. Online ahead of print.ABSTRACTBACKGROUND: Coffee is one of the most widely consumed beverages worldwide, yet its biological effects have often been attributed primarily to caffeine. Emerging evidence suggests that coffee contains a complex

Z Zhaochang Jiang

Surgical management of an acquired aortic interruption suspected from severe aortic coarctation in an adult with massive collaterals

J Cardiothorac Surg. 2026 Jul 17. doi: 10.1186/s13019-026-04600-0. Online ahead of print.ABSTRACTBACKGROUND: Interrupted aortic arch (IAA) is a severe congenital anomaly typically fatal in infancy without surgical intervention. Adult presentation of isolated IAA is exceedingly rare and usually relie

M Min Qiu

Valve-specific structural vulnerability in infective endocarditis: a narrative review of surgical complexity and outcomes

J Cardiothorac Surg. 2026 Jul 17. doi: 10.1186/s13019-026-04523-w. Online ahead of print.ABSTRACTBACKGROUND: Infective endocarditis (IE) carries in-hospital mortality of 15-20% and 1-year mortality approaching 40%, with surgery required in 40-50% of cases. IE is not uniformly distributed across card

N Najmi Hakim Abd Rani

Burden and determinants of hyperuricemia among adults living with HIV at Lira Regional Referral Hospital in Uganda : a cross-sectional study

AIDS Res Ther. 2026 Jul 18. doi: 10.1186/s12981-026-00923-z. Online ahead of print.ABSTRACTBACKGROUND: Hyperuricemia is an emerging metabolic complication among people living with HIV in the era of antiretroviral therapy (ART), yet evidence from sub-Saharan Africa remains limited.METHODS: A cross-se

F Fatima Ibrahim Nor

Associations of cumulative exposure and dynamic trajectories of the cholesterol-HDL-glucose index and its obesity-related derivatives with cardiovascular disease: a nationwide prospective cohort study

Cardiovasc Diabetol. 2026 Jul 17. doi: 10.1186/s12933-026-03295-w. Online ahead of print.ABSTRACTBACKGROUND: Integrating metabolic biomarkers with anthropometric indicators has been shown to enhance the discriminative capacity for cardiovascular disease (CVD). However, the impact of the cholesterol-

H Han Wang

Lipoprotein(a), insulin resistance, and cardiovascular outcomes in metabolic dysfunction-associated steatotic liver disease

Cardiovasc Diabetol. 2026 Jul 17. doi: 10.1186/s12933-026-03294-x. Online ahead of print.ABSTRACTBACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with increased cardiovascular disease (CVD) risk. Lipoprotein(a) [Lp(a)] and insulin resistance (IR) are establi

B Bingtian Dong

Prevalence of choroidal naevi in Germany: a cross-sectional analysis of the BiDirect study

BMC Ophthalmol. 2026 Jul 17. doi: 10.1186/s12886-026-05129-5. Online ahead of print.ABSTRACTBACKGROUND: Choroidal naevi (CN) are small, and mostly asymptomatic choroidal lesions. Despite their benignity, identification and follow-up of CN is required as malignant transformation is possible. CN preva

M Mael Lever

Optimizing coronary artery disease management: the role of CT-derived fractional flow reserve in predicting revascularization and guiding clinical decisions

BMC Med Imaging. 2026 Jul 17. doi: 10.1186/s12880-026-02594-8. Online ahead of print.ABSTRACTOBJECTIVE: Coronary artery disease (CAD) is the most common heart disease, and invasive coronary angiography (ICA) has been recognized as the gold standard for diagnosing CAD. However, this method is influen

J Jian Huang

National survey of blood pressure management practices in peritoneal dialysis

BMC Nephrol. 2026 Jul 17. doi: 10.1186/s12882-026-05201-8. Online ahead of print.ABSTRACTBACKGROUND: Contemporary practices for blood pressure (BP) management in peritoneal dialysis (PD) remain poorly characterized despite cardiovascular disease and hypertension being highly prevalent in patients on

K Kashvi Gupta

Integrating multiple hematologic inflammatory indices into a principal component analysis-derived inflammatory burden score for coronary artery disease

BMC Cardiovasc Disord. 2026 Jul 17. doi: 10.1186/s12872-026-06315-5. Online ahead of print.ABSTRACTBACKGROUND: Complete blood count-derived inflammatory indices have been associated with coronary artery disease (CAD), but their substantial overlap may limit interpretability when assessed individuall

M Mert Deniz Savcilioglu

The impact of diabetes on clinical outcomes in acutely ill patients - a study on patients admitted to the emergency department

BMC Cardiovasc Disord. 2026 Jul 18;26(1):609. doi: 10.1186/s12872-026-06311-9.ABSTRACTBACKGROUND: Individuals with diabetes have an increased risk of cardiovascular disease, infection, hospitalization, and premature mortality. However, less is known about how diabetes shapes the broader pattern of e

P Per Wändell

IRAK-M attenuates pain hypersensitivity and anxiety-like behaviors in a nitroglycerin-induced chronic migraine mouse model with concomitant reductions in microglial activation and neuroinflammation

J Headache Pain. 2026 Jul 17. doi: 10.1186/s10194-026-02457-1. Online ahead of print.ABSTRACTBACKGROUND: Chronic migraine (CM) is a disabling neurological disorder in which neuroinflammatory mechanisms and central sensitization are thought to contribute to disease pathophysiology. Interleukin-1 rece

X Xiao-Tao Liang

Stakeholder experiences and expectations of transition of care services to reduce medication-related hospital readmission for cardiology patients

BMC Cardiovasc Disord. 2026 Jul 18. doi: 10.1186/s12872-026-06294-7. Online ahead of print.ABSTRACTBACKGROUND: Transition of care (ToC) for patients with cardiovascular diseases is a complex, high-risk period often leading to medication-related harm (MRH) and hospital readmissions. While specialised

S Shelley A Wilkinson

Biological effects of 18F-FDG administration and CT dose during PET/CT: chromosomal aberrations in a two-center prospective observational study

Eur Radiol. 2026 Jul 17. doi: 10.1007/s00330-026-12731-0. Online ahead of print.ABSTRACTOBJECTIVE: To assess the radiation effects of internal 18F-fluorodeoxyglucose (FDG) administration and external CT exposures during PET/CT, using reduced-dose and standard-dose CT protocols, on chromosomes in per

Y Yuri Kawashima

Adopting the lancet commission definition of clinical obesity in metabolic dysfunction-associated steatotic liver disease (MASLD)

Int J Obes (Lond). 2026 Jul 17. doi: 10.1038/s41366-026-02173-5. Online ahead of print.ABSTRACTBACKGROUND: The Lancet Diabetes & Endocrinology Commission proposed a new definition of clinical obesity. We applied clinical obesity in a cohort of Asian patients with metabolic dysfunction-associated ste

K Karen Cheuk-Ying Ho

Gender-specific associations between metabolic syndrome components and electrocardiographic abnormalities: evidence from Birjand University of medical sciences employee health study (BUMS EHCS)

Sci Rep. 2026 Jul 17. doi: 10.1038/s41598-026-62213-y. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide. Metabolic syndrome (MetS), which consists of a group of metabolic risk factors, greatly elevates the risk of CVD. This st

M Mostafa Parizadeh

Reliability and validity of the DEFISS score for predicting post-extubation dysphagia and dysphagia-related reintubation after stroke

Sci Rep. 2026 Jul 17;16(1):22536. doi: 10.1038/s41598-026-62133-x.ABSTRACTPost-extubation dysphagia is frequent after severe stroke and can lead to pneumonia, delayed recovery, and dysphagia-related reintubation. We evaluated the Determine Extubation Failure in Severe Stroke (DEFISS) score, a bedsid

P Paul Muhle

The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease

Br J Pharmacol. 2026 Jul 17. doi: 10.1111/bph.70584. Online ahead of print.ABSTRACTCardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from end

S Shreya Mahabhashyam

Association of Acute Kidney Injury and Chronic Kidney Disease With Concentration-To-Dose Ratios of Midazolam and Its Main Metabolites in Critically Ill Adults

Fundam Clin Pharmacol. 2026 Jul;40(4):e70108. doi: 10.1111/fcp.70108.ABSTRACTBACKGROUND: Midazolam (MDZ) is used for sedation in critically ill patients. Although previous studies have examined MDZ pharmacokinetics in ICU patients, the differential effects of acute kidney injury (AKI) and chronic ki

K Kimberly Shudofsky

Dietary and lifestyle interventions for overweight and obesity in post-acute stroke rehabilitation: a scoping review

BMJ Open. 2026 Jul 17;16(7):e120345. doi: 10.1136/bmjopen-2026-120345.ABSTRACTOBJECTIVE: Overweight and obesity are prevalent among individuals in post-acute stroke rehabilitation and are associated with poorer functional outcomes and increased cardiovascular risk. Interventions targeting weight man

M Mette Nørtoft

Occupational factors and sex differences after myocardial infarction in working-age adults in Spain: a population-based cross-sectional study

BMJ Open. 2026 Jul 17;16(7):e119497. doi: 10.1136/bmjopen-2026-119497.ABSTRACTOBJECTIVES: Myocardial infarction (MI) is a major contributor to global disease burden with societal impact among survivors. This study aimed to estimate the population-level prevalence of MI among working-age adults in Sp

C Caterina Checa

Diagnosis of postoperative atrial fibrillation using smartwatch monitoring after cardiac surgery: protocol for the FAWATCH single-centre, open-label, randomised controlled trial

BMJ Open. 2026 Jul 17;16(7):e118691. doi: 10.1136/bmjopen-2026-118691.ABSTRACTINTRODUCTION: Postoperative atrial fibrillation (POAF) remains the most frequent arrhythmic complication after cardiac surgery, with most episodes occurring after discharge from the intensive care unit (ICU) when continuou

C Christophe Beyls

From "The More, the Better" to "Precise Balance": The U-Shaped Curve of Vitamin D Supplementation and the Reassessment of Optimal Levels

Clin Nutr ESPEN. 2026 Jul 17:103599. doi: 10.1016/j.clnesp.2026.103599. Online ahead of print.ABSTRACTThe role of vitamin D supplementation in health outcomes remains a subject of debate. While severe deficiency has been linked to conditions such as rickets, osteomalacia, and secondary hyperparathyr

F Fan Zhang

Risks of Postpartum Kidney Disease Following Preeclampsia and Gestational Hypertension

Am J Kidney Dis. 2026 Jul 17:S0272-6386(26)01004-8. doi: 10.1053/j.ajkd.2026.04.016. Online ahead of print.ABSTRACTRATIONALE & OBJECTIVE: Preeclampsia and gestational hypertension affect over 1 in 8 pregnancies in the US. Gestational hypertension differs, in part, from preeclampsia by not being asso

R Ruby Lin