Ezetimibe and the risk of new-onset type 2 diabetes: a systematic review and meta-analysis

Ann Med. 2025 Dec;57(1):2594355. doi: 10.1080/07853890.2025.2594355. Epub 2025 Nov 30.ABSTRACTBACKGROUND: Statins reduce cardiovascular risk but may increase new-onset type 2 diabetes mellitus (NO-T2DM). Ezetimibe, a cholesterol absorption inhibitor, is often added to statins to improve lipid contro

A Areej S Albawa'neh

Critical Care Outcomes in Pediatric Hematopoietic Stem Cell Transplantation: A Single-Center Pediatric Intensive Care Unit Experience

Pediatr Transplant. 2025 Dec;29(8):e70239. doi: 10.1111/petr.70239.ABSTRACTBACKGROUND: Hematopoietic stem cell transplantation (HSCT) has become an essential curative strategy for various malignant and non-malignant pediatric diseases. However, HSCT recipients remain highly vulnerable to complicatio

E Emel Uyar

Diagnosis and treatment of coronary artery disease in patients with chronic kidney disease

Expert Rev Cardiovasc Ther. 2025 Nov 30. doi: 10.1080/14779072.2025.2597772. Online ahead of print.ABSTRACTINTRODUCTION: Patients with chronic kidney disease (CKD) have a significantly elevated risk of coronary artery disease. The relationship between CAD and CKD is multifaceted involving complex ph

R Rohan Dod

Lactate dehydrogenase and short-term mortality in ICU patients with ischemic stroke: a single-center retrospective analysis of MIMIC-IV

Eur J Med Res. 2025 Dec 1;30(1):1196. doi: 10.1186/s40001-025-03492-5.ABSTRACTBACKGROUND AND AIMS: Elevated lactate dehydrogenase (LDH) has been linked to unfavorable outcomes across various diseases, yet its prognostic relevance in critically ill patients with ischemic stroke (IS) remains insuffici

D Da Zhou

Differences in cardiovascular disease incidence according to changes in obesity status in young diabetic patients

Cardiovasc Diabetol Endocrinol Rep. 2025 Dec 1;11(1):35. doi: 10.1186/s40842-025-00249-1.ABSTRACTBACKGROUND: The relationship between obesity and cardiovascular disease (CVD) in obese patients with young-onset diabetes remains unclear. We investigated the incidence of CVD and the impact of changes i

D Do Kyeong Song

Heart failure with preserved ejection fraction, from pathophysiology to technology tools aim improve patients' management

Heart Fail Rev. 2025 Dec 1;31(1):3. doi: 10.1007/s10741-025-10585-0.ABSTRACTHeart failure with preserved ejection fraction (HFpEF) accounts for nearly 50% of all heart failure cases and remains a significant clinical challenge. It is characterized by a complex pathophysiology involving multiple como

A Andrea Pozzi

Patient Characteristics Across Lipoprotein(a) Levels: Insights From a Retrospective Study

Lipids. 2025 Nov 30. doi: 10.1002/lipd.70025. Online ahead of print.ABSTRACTElevated plasma lipoprotein(a) (Lp(a)) (> 125 nmol/L) is highly prevalent and a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) that may contribute significantly to plasma levels of low-density lipoprot

C Clara M Howell

Ruptured right atrial hydatid cyst causing anaphylactic shock in a child: a rare and life-threatening case

Cardiol Young. 2025 Nov;35(11):2400-2402. doi: 10.1017/S1047951125109803. Epub 2025 Dec 1.ABSTRACTHydatid cyst is an infectious disease that occurs in humans due to infection of Echinococcus granulosus larvae. Although cardiac hydatid cysts are rare, right atrial localisation is even rarer. The aim

H Hüseyin Ceylan

The effect of different coronary artery flow isolation techniques in off-pump coronary artery bypass grafting

Zhonghua Yi Xue Za Zhi. 2025 Dec 2;105(44):4076-4080. doi: 10.3760/cma.j.cn112137-20250621-01515.ABSTRACTObjective: To explore the clinical effect of different coronary artery flow isolation methods in off-pump coronary artery bypass grafting (OPCABG). Methods: A total of 60 patients who accepted OP

L L H Guo

Cardiovascular morbidity and mortality in gout: is gout an Independent risk Factor?

Expert Opin Pharmacother. 2025 Nov 30. doi: 10.1080/14656566.2025.2597993. Online ahead of print.ABSTRACTINTRODUCTION: Gout is the most common inflammatory arthritis in adults in the U.S. and worldwide. Men are affected more than women, and cardiometabolic diseases frequently accompany this conditio

J Jasvinder A Singh

Mechanical Thrombectomy Reduces Increased High Sensitivity Troponin Levels in Intermediate-High Risk Pulmonary Embolism

Heart Lung Circ. 2025 Nov 29:S1443-9506(25)01617-8. doi: 10.1016/j.hlc.2025.08.023. Online ahead of print.ABSTRACTBACKGROUND: Pulmonary embolism is associated with significant mortality and remarkably often subject to misdiagnosis, which further adversely affects prognosis. Disease severity and corr

R Richard Schell

Vascular complications and imaging-based cardiovascular risk assessment in Mucopolysaccharidoses: A systematic review

Mol Genet Metab. 2025 Nov 27:109687. doi: 10.1016/j.ymgme.2025.109687. Online ahead of print.ABSTRACTBACKGROUND: Mucopolysaccharidoses (MPS) are lysosomal storage disorders characterised by glycosaminoglycan (GAG) accumulation, leading to progressive multisystem disease. Cardiovascular complications

E Eamon P McCarron

CAR-T cell therapy for multiple myeloma: An update on the current state and future potential

Best Pract Res Clin Haematol. 2025 Dec;38(4):101659. doi: 10.1016/j.beha.2025.101659. Epub 2025 Oct 4.ABSTRACTThe field of multiple myeloma (MM) has seen significant therapeutic advances over the last decade including the recent advent of Chimeric Antigen Receptor T cell (CAR-T) therapy. Currently t

P Prateek Pophali

Causal Relationship Between Hypertension and Schizophrenia

Int Heart J. 2025;66(6):995-1001. doi: 10.1536/ihj.24-768.ABSTRACTHypertension is a significant risk factor for cardiovascular diseases, kidney disease, and psychiatric illnesses, and a major global issue. Schizophrenia is a chronic psychiatric disorder with inconsistent behavioral and cognitive abn

C ChaoBiao Xue

Silencing of MiR-329-3p Protects against Myocardial Ischemia-Reperfusion Injury by Regulating the Wnt/β-catenin Pathway via Nemo-Like Kinase

Int Heart J. 2025;66(6):986-994. doi: 10.1536/ihj.24-790.ABSTRACTAcute myocardial infarction is a major global cause of death. Myocardial ischemia-reperfusion (MI/R) injury occurs immediately after coronary reperfusion and exacerbates myocardial ischemia.Our work aims to elucidate the role and targe

L Longfei Wang

Direct Fast Scarlet and Congo Red Staining in Identification of Eosinophils and Their Cell-Free Granules in Cardiac Tissue

Int Heart J. 2025;66(6):968-977. doi: 10.1536/ihj.25-317.ABSTRACTCell-free eosinophil granules, harmful to the heart, are stained red by haematoxylin-eosin (HE); however, they can be overlooked in cardiac tissues. Direct fast scarlet (DFS) and Congo red (CR), known for staining amyloids, may offer c

T Takayuki Kumaki

Long-Term Prognostic Value of Albumin-Bilirubin Score at Discharge in Patients with Acute Heart Failure

Int Heart J. 2025;66(6):956-960. doi: 10.1536/ihj.25-250.ABSTRACTLiver dysfunction is associated with poorer outcomes in patients with heart failure (HF). The albumin-bilirubin (ALBI) score, which combines serum albumin and total bilirubin levels, has recently emerged as a useful tool to assess live

M Makoto Kishihara

GATA3 and IFNG as Potential Molecular Biomarkers for Differentiating Heart Failure with Preserved Ejection Fraction with Normal Versus Elevated BNP Levels

Int Heart J. 2025;66(6):947-955. doi: 10.1536/ihj.25-159.ABSTRACTThis study aimed to investigate differentially expressed mRNA transcripts between patients with heart failure with preserved ejection fraction (HFpEF) exhibiting normal versus elevated B-type natriuretic peptide (BNP) levels, thereby s

X Xinyi Wang

The Association Between Body Mass Index and In-hospital Mortality in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Int Heart J. 2025;66(6):933-940. doi: 10.1536/ihj.25-135.ABSTRACTThe relationship of body mass index (BMI) with clinical outcomes in patients with acute myocardial infarction (AMI) remains incompletely understood. In this study, 1113 patients with AMI who underwent percutaneous coronary intervention

T Takuya Nakahashi

Cardiac Angiosarcoma

Int Heart J. 2025;66(6):1025-1028. doi: 10.1536/ihj.25-303.ABSTRACTAngiosarcoma is the most aggressive primary malignant cardiac tumor, typically involving the right atrium and characterized by its high invasiveness, rapid progression, and nonspecific clinical manifestations. The patient presented w

C Chu Chen

USP30 Knockdown Drives Mitophagy and Suppresses Pyroptosis in Heart Failure by Activating the PINK1/Parkin Pathway

Int Heart J. 2025;66(6):1002-1014. doi: 10.1536/ihj.24-738.ABSTRACTThis study probed into the mechanism of USP30 in mitophagy and pyroptosis during heart failure (HF).A cell model was constructed with oxygen-glucose deprivation (OGD), and an HF rat model was generated by permanently ligating the lef

Y Yanna Yang

Prosthetic annulus size mismatch and recurrent mitral regurgitation after repair in advanced degenerative disease

Heart. 2025 Nov 30:heartjnl-2025-325968. doi: 10.1136/heartjnl-2025-325968. Online ahead of print.ABSTRACTBACKGROUND: Recurrent mitral regurgitation (MR) remains a major limitation of mitral valve (MV) repair in patients with advanced degenerative MR (asDMR) and left ventricular (LV) enlargement. We

M Ming Chen

Treatment outcome of acute coronary syndrome and associated factors among patients admitted to public hospitals in Harari Regional State, Eastern Ethiopia: a retrospective cross-sectional study

BMJ Open. 2025 Nov 29;15(11):e105208. doi: 10.1136/bmjopen-2025-105208.ABSTRACTBACKGROUND: Acute coronary syndrome (ACS) is the leading cause of morbidity and mortality among individuals with cardiovascular disease, accounting for half of all global cardiovascular-related deaths. No prior research h

T Teshager Belay Tessema

How can we improve migrant health checks in UK primary care: 'Health Catch-UP!' a protocol for a participatory intervention development study

BMJ Open. 2025 Nov 29;15(11):e106484. doi: 10.1136/bmjopen-2025-106484.ABSTRACTINTRODUCTION: Global migration has steadily risen, with 16% of the UK population born abroad. Migrants (defined here as foreign-born individuals) face unique health risks, including potential higher rates and delays in di

J Jessica Carter