Response to "Aspirin for Primary Prevention in Metabolic Dysfunction-Associated Steatotic Liver Disease"
No abstractHepatol Res. 2026 Jan 22. doi: 10.1111/hepr.70123. Online ahead of print.NO ABSTRACTPMID:41568574 | DOI:10.1111/hepr.70123
Circulating Neutrophil and Monocyte Counts Are Inversely Associated With Heart Rate Variability Indices: The Maastricht Study
J Am Heart Assoc. 2026 Jan 22:e043994. doi: 10.1161/JAHA.125.043994. Online ahead of print.ABSTRACTBACKGROUND: Inflammatory biomarkers, including immune cells appear associated with reduced heart rate variability (HRV), an indicator of cardiac autonomic nervous dysfunction. However, the influence of
CAV1-A Susceptibility Gene for Atrial Fibrillation: The Impact of Coding and Noncoding Variants
J Am Heart Assoc. 2026 Jan 22:e041586. doi: 10.1161/JAHA.125.041586. Online ahead of print.ABSTRACTBACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia with a strong genetic predisposition. Genome-wide association studies have highlighted CAV1 (caveolin 1), a caveolar
Cardiovascular Risk Management in Adults With Diagnosed Diabetes in Mexico From 2016 to 2023: A Retrospective Analysis of Nationally Representative Surveys
J Am Heart Assoc. 2026 Jan 22:e044366. doi: 10.1161/JAHA.125.044366. Online ahead of print.ABSTRACTBACKGROUND: Effective cardiovascular disease (CVD) risk management is essential for optimal diabetes care. Here, we estimated the prevalence and determinants of CVD risk factor control among individual
Trends and Disparities in Cardiovascular Mortality among HIV-Positive Adults in the United States (2004-2020): A CDC WONDER Database Analysis
Curr HIV Res. 2026 Jan 9. doi: 10.2174/011570162X379326251026150021. Online ahead of print.ABSTRACTINTRODUCTION: A growing link is observed between cardiovascular disease (CVD) and human immunodeficiency virus (HIV), with more results demonstrating a higher CVD incidence among the HIV population. As
Integrative Approaches to Uncover the Therapeutic Action of Huaiqihuang in Myocarditis: Network Pharmacology, Molecular Docking, and Molecular Dynamics
Curr Pharm Des. 2026 Jan 9. doi: 10.2174/0113816128393399251021101651. Online ahead of print.ABSTRACTINTRODUCTION: Myocarditis (MC) is an inflammatory cardiomyopathy with high morbidity and mortality. Current treatment options for MC have limitations and side effects, necessitating the exploration o
Fluctuations in Sleep Duration and Timing and Cardiometabolic Risk
Arterioscler Thromb Vasc Biol. 2026 Jan 22. doi: 10.1161/ATVBAHA.125.322872. Online ahead of print.ABSTRACTSleep behavior has emerged as an important determinant of cardiometabolic health. However, to date, much attention has focused on sleep duration with accumulating evidence resulting in leading
Sex-Specific Differences in PVAT Pathobiology
Arterioscler Thromb Vasc Biol. 2026 Jan 22. doi: 10.1161/ATVBAHA.125.323335. Online ahead of print.ABSTRACTPerivascular adipose tissue (PVAT) has been widely studied over the past 2 decades for its anticontractile function, morphology, and adipokine secretion. However, most data were obtained from m
Trained Immunity in Interorgan Communication and Vascular Inflammation
Arterioscler Thromb Vasc Biol. 2026 Jan 22. doi: 10.1161/ATVBAHA.125.323130. Online ahead of print.ABSTRACTDespite major advances in acute reperfusion therapies, patients surviving ischemic stroke or myocardial infarction remain at high risk for long-term cardiovascular and metabolic comorbidities.
Pathogenesis of Pulmonary Artery Remodeling: TGF-Beta Signaling and Inhibin Subunit Beta A in Group 1 and 2 Pulmonary Hypertension
Arterioscler Thromb Vasc Biol. 2026 Jan 22. doi: 10.1161/ATVBAHA.125.322506. Online ahead of print.ABSTRACTBACKGROUND: Pulmonary hypertension (PH) due to left heart disease (group 2 PH) is associated with a worse prognosis than isolated heart failure. Both pulmonary arterial hypertension (group 1 PH
Association of Clinic Blood Pressure and Out-of-Clinic Blood Pressure Difference With Falls Among Older Adults With Hypertension
Hypertension. 2026 Jan 22. doi: 10.1161/HYPERTENSIONAHA.125.25783. Online ahead of print.ABSTRACTBACKGROUND: A barrier to intensification of antihypertensive medication among older adults with hypertension is the perceived risk of falls. Blood pressure (BP) measured in the clinic setting is primaril
Assessment of the safety and effectiveness of catheter-based renal denervation with the symplicity spyral system in patients with resistant hypertension: A single-center experience
Clin Exp Hypertens. 2026 Dec 31;48(1):2617997. doi: 10.1080/10641963.2026.2617997. Epub 2026 Jan 22.ABSTRACTBACKGROUND: Renal denervation (RDN) has emerged as a potential therapeutic option for resistant hypertension (HT), which remains a major clinical challenge due to poor blood pressure (BP) cont
Nocturnal Hypertension and Prognosis in Patients of Very Advanced Age
Hypertension. 2026 Jan 22. doi: 10.1161/HYPERTENSIONAHA.125.25199. Online ahead of print.ABSTRACTBACKGROUND: Nocturnal blood pressure (BP) is a better predictor of health outcomes than office or daytime BP. However, the clinical significance of nocturnal hypertension in patients of very advanced age
Polycystic Ovarian Syndrome and the Long-term Risk of Arrhythmias
Circulation. 2026 Jan 22. doi: 10.1161/CIRCULATIONAHA.125.078039. Online ahead of print.ABSTRACTBACKGROUND: Polycystic ovarian syndrome (PCOS) is associated with increased cardiovascular morbidity and a higher risk of atherosclerotic cardiovascular disease. PCOS has been associated with electrocardi
Identification of a peptide inhibitor disrupting the PCSK9-LDLR interaction via pharmacophore-based virtual screening, molecular dynamics simulations and in vitro/vivo evaluation
J Enzyme Inhib Med Chem. 2026 Dec;41(1):2610849. doi: 10.1080/14756366.2025.2610849. Epub 2026 Jan 22.ABSTRACTThe PCSK9-LDLR interaction, driving elevated LDL-C, is a key driver of ASCVD pathogenesis. Identifying peptides disrupting this interaction offers an alternative ASCVD therapy. Herein, via s
Microbial Metabolite 4EPS Inhibits AT1R to Reduce Blood Pressure and Aortic Aneurysm Outcome
Hypertension. 2026 Jan 22. doi: 10.1161/HYPERTENSIONAHA.125.25364. Online ahead of print.ABSTRACTBACKGROUND: Plasma accumulation of the gut microbial metabolite 4-ethylphenylsulfate (4EPS), derived from dietary amino acid, tyrosine, has been associated with cardiovascular, renal, metabolic, and neur
TPM1-p.E181K mutation suppresses CaMKII/HDAC4 signaling pathway leading to pediatric restrictive cardiomyopathy
Front Genet. 2026 Jan 7;16:1654907. doi: 10.3389/fgene.2025.1654907. eCollection 2025.ABSTRACTBACKGROUND: This study aims to elucidate the pathogenicity of the TPM1 mutation (NM_001018005.2:c.541G>A, p. Glu181Lys) in restrictive cardiomyopathy (RCM), establish its ACMG pathogenicity classification,
Case report of a huge adrenal pseudocystic tumour with dopamine secretion: treatment paradigm from a very rare case
J Surg Case Rep. 2026 Jan 20;2026(1):rjaf1092. doi: 10.1093/jscr/rjaf1092. eCollection 2026 Jan.ABSTRACTPheochromocytomas and extra-adrenal paragangliomas are rare neuroendocrine tumors typically characterized by excess secretion of epinephrine and/or norepinephrine. Dopamine secreting tumors are ev
Total venous coronary artery bypass grafting for acute myocardial infarction with Leriche syndrome and porcelain aorta: a case report
J Surg Case Rep. 2026 Jan 20;2026(1):rjaf1102. doi: 10.1093/jscr/rjaf1102. eCollection 2026 Jan.ABSTRACTLeriche syndrome is an occlusive disease involving the abdominal aorta and iliac arteries that is frequently associated with ischemic heart disease (IHD). The internal thoracic arteries in patient
A Pathway to High Quality Clinical Trials in IgA Vasculitis Nephritis: Meeting Proceedings From a Multiprofessional International Collaborative Workshop
Kidney Int Rep. 2025 Dec 16;11(3):103729. doi: 10.1016/j.ekir.2025.103729. eCollection 2026 Mar.ABSTRACTIgA vasculitis (IgAV) is an autoimmune disease that affects the small vessels of the skin, joints, gastrointestinal (GI) tract, and kidneys. In the long term, IgAV associated with nephritis (IgAV-
Symptom phenotypes and coronary microvascular function in non-obstructive coronary artery disease: Insights beyond epicardial ischemia
Am Heart J Plus. 2026 Jan 7;62:100714. doi: 10.1016/j.ahjo.2026.100714. eCollection 2026 Feb.ABSTRACTSTUDY OBJECTIVE: To examine the relationship between coronary microvascular dysfunction (CMD) indices and chest pain presentation in patients with non-obstructive coronary artery disease (NOCA).DESIG
A noninvasive strategy for multi-disease diagnosis via multi-sensor platform: integrative analysis of five years of exhaled breath-based diagnostics for seven diseases
Front Bioeng Biotechnol. 2026 Jan 6;13:1750962. doi: 10.3389/fbioe.2025.1750962. eCollection 2025.ABSTRACTSensors used for collecting high-value physiological and biochemical data strongly support a precision medicine approach, by enabling the integration of these complex datasets with routine clini
Is the coexistence of diabetes and hypertension liable for a higher risk of cardiovascular disorders among Saudis?
Am J Blood Res. 2025 Dec 15;15(5):102-109. doi: 10.62347/VJPZ6106. eCollection 2025.ABSTRACTBACKGROUND: Cardiovascular diseases (CVDs) are experiencing a notable increase globally, largely influenced by the related rise in risk factors, including type 2 diabetes mellitus (T2DM) and hypertension (HTN
Association between nocturnal ozone enhancement and daily cardiovascular mortality: A multi-city study in China
The health effects of ambient ozone (O(3)) pollution have been well documented, but most studies have focused on daytime exposure, with limited research on nighttime O(3). Nocturnal O(3) enhancement (NOE) refers to unexpected increases in nighttime O(3) concentrations over a few hours, yet the healt