Cytokine specificity in macrophages: JAK-STAT and beyond

Trends Immunol. 2026 Feb 27:S1471-4906(26)00002-5. doi: 10.1016/j.it.2026.01.002. Online ahead of print.ABSTRACTMacrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cyto

J Josje M A Huisman

Cracking Coronary Calcium with Intravascular Lithotripsy A Review

Am J Cardiol. 2026 Feb 26:S0002-9149(26)00083-4. doi: 10.1016/j.amjcard.2026.02.032. Online ahead of print.ABSTRACTCalcified coronary lesions (CCL) remain a major challenge in percutaneous coronary intervention, often limiting stent expansion and worsening long-term outcomes. Conventional calcium mo

S Sachin Kumar

Antiarrhythmic drugs to prevent sudden cardiac death: Is there a way forward?

Pharmacol Ther. 2026 Feb 26:109012. doi: 10.1016/j.pharmthera.2026.109012. Online ahead of print.ABSTRACTSudden cardiac death (SCD) is responsible for approximately 15-20% of deaths worldwide. The majority of SCD cases can be attributed to lethal ventricular arrhythmias arising due to coronary heart

I Iris Zieler

From survival to freedom: redefining success in type 1 diabetes

Lancet Diabetes Endocrinol. 2026 Feb 25:S2213-8587(26)00003-3. doi: 10.1016/S2213-8587(26)00003-3. Online ahead of print.ABSTRACTType 1 diabetes has shifted from a condition once associated with early mortality to a chronic disease owing to the development of intensive insulin therapy, continuous gl

L Lorenzo Piemonti

Unveiling the unpredictable: A comprehensive inquiry into sudden and unexpected deaths undergoing medico-legal investigation at Tygerberg Forensic Pathology Services Mortuary

J Forensic Leg Med. 2026 Feb 24;119:103109. doi: 10.1016/j.jflm.2026.103109. Online ahead of print.ABSTRACTPURPOSE: Sudden and unexpected death (SUD) is the abrupt death of a seemingly healthy individual, which requires medico-legal investigation under the South African Inquest Act (1959) and the Na

N Nicholas Jooste-Coetsee