Wiad Lek. 2025;78(9):1874-1885. doi: 10.36740/WLek/209684.ABSTRACTFor centuries, knowledge about the heart, one of the most important organs in the human body, was limited to assumptions and theories. These ideas often served as a basis for understanding the functioning of the circulatory system, bu
Wiad Lek. 2025;78(9):1857-1865. doi: 10.36740/WLek/212515.ABSTRACTOBJECTIVE: Aim: The aim of this review article is to provide a comprehensive analysis of the impact of lifestyle interventions - dietary modifications, physical activity, and behavioral strategies - on the management of metabolic synd
Wiad Lek. 2025;78(9):1751-1757. doi: 10.36740/WLek/212506.ABSTRACTOBJECTIVE: Aim: To identify factors associated with the risk of developing abdominal compartment syndrome (ACS) in patients with severe acute pancreatitis (SAP).PATIENTS AND METHODS: Materials and Methods: A retrospective single-cente
Wiad Lek. 2025;78(9):1731-1740. doi: 10.36740/WLek/212416.ABSTRACTOBJECTIVE: Aim: To evaluate central haemodynamic parameters in the long-term period after inferior vena cava (IVC) thrombosis depending on the treatment method.PATIENTS AND METHODS: Materials and Methods: Blood flow parameters were ev
Neurology. 2025 Nov 25;105(10):e214345. doi: 10.1212/WNL.0000000000214345. Epub 2025 Oct 29.ABSTRACTOBJECTIVES: Nonischemic cerebral enhancing (NICE) foreign-body granulomatous lesions are an immune-mediated complication of endovascular therapy (EVT). No single immunotherapy has demonstrated consist
Neurology. 2025 Nov 25;105(10):e214338. doi: 10.1212/WNL.0000000000214338. Epub 2025 Oct 29.ABSTRACTBACKGROUND AND OBJECTIVES: Diffusion-weighted imaging (DWI)-positive lesions are identified in 11%-45% of patients with acute intracerebral hemorrhage (ICH); however, their underlying mechanisms and c
Epigenetics. 2025 Dec;20(1):2576069. doi: 10.1080/15592294.2025.2576069. Epub 2025 Oct 29.ABSTRACTLactate, long regarded as a metabolic byproduct of anaerobic glycolysis, has emerged as a key regulator of cardiovascular health. Its roles extend beyond energy metabolism and include cell signaling thr
Annu Rev Med. 2025 Oct 29. doi: 10.1146/annurev-med-050224-103456. Online ahead of print.ABSTRACTKawasaki disease (KD) is an acute, self-limiting vasculitis that primarily affects children under 5 years old. KD manifests as a persistent fever in the presence of mucocutaneous inflammation and lymphad
Annu Rev Med. 2025 Oct 29. doi: 10.1146/annurev-med-043024-011141. Online ahead of print.ABSTRACTGlucagon-like peptide 1 receptor (GLP-1R) agonists were originally developed as treatments for diabetes and subsequently evolved into weight management medications. These drugs have recently been shown t
J Cell Mol Med. 2025 Nov;29(21):e70920. doi: 10.1111/jcmm.70920.ABSTRACTMicronutrients, though required in relatively small quantities by the human body, are essential for maintaining normal physiological functions and play a crucial role in the prevention and management of various diseases. Atheros
Cardiovasc Res. 2025 Oct 29:cvaf207. doi: 10.1093/cvr/cvaf207. Online ahead of print.ABSTRACTAIMS: Elevated sympathetic nerve activity (eSNA) is a hallmark of cardiovascular disease and represents an important clinical target for disease management. A known driver of eSNA is aberrant signalling from
Sci Adv. 2025 Oct 31;11(44):eady0415. doi: 10.1126/sciadv.ady0415. Epub 2025 Oct 29.ABSTRACTBrown adipose tissue (BAT) protects against obesity, diabetes, and cardiovascular disease. During BAT activation, macroautophagy is inhibited, while chaperone-mediated autophagy (CMA) is induced, promoting th
Sci Transl Med. 2025 Oct 29;17(822):eadv6787. doi: 10.1126/scitranslmed.adv6787. Epub 2025 Oct 29.ABSTRACTTime-restricted eating (TRE) is a promising strategy to improve metabolic outcomes. However, it remains unclear whether TRE has cardiometabolic benefits in an isocaloric setting and whether its
PLoS One. 2025 Oct 29;20(10):e0334094. doi: 10.1371/journal.pone.0334094. eCollection 2025.ABSTRACTOBJECTIVE: Postoperative delirium is a common complication after neurosurgery. The association between intraoperative hypotension and postoperative delirium in the neurosurgical population is unknown.D
PLoS One. 2025 Oct 29;20(10):e0335421. doi: 10.1371/journal.pone.0335421. eCollection 2025.ABSTRACTCardiovascular disease (CVD) is considered the number one killer disease in the world, underlining the importance of the application of more accurate diagnostic and therapeutic tools. Traditional scree
PLoS One. 2025 Oct 29;20(10):e0335467. doi: 10.1371/journal.pone.0335467. eCollection 2025.ABSTRACTOBJECTIVE: This study aimed to investigate the independent and synergistic effects of social isolation and multidimensional biomarkers (cardiovascular, metabolic, renal, muscular, and frailty) on physi
PLoS One. 2025 Oct 29;20(10):e0334086. doi: 10.1371/journal.pone.0334086. eCollection 2025.ABSTRACTAtrial fibrillation (AF) remains the leading cardiac cause of stroke and AF-related death rate in the United States has been increasing for over twenty years. While the effect of standalone AF on heart
PLoS One. 2025 Oct 29;20(10):e0335669. doi: 10.1371/journal.pone.0335669. eCollection 2025.ABSTRACTUnderstanding the place of cardiovascular disease (CVD) deaths is essential for identifying vulnerable populations and guiding health system interventions. This study investigated the demographic and c
PLoS One. 2025 Oct 29;20(10):e0334255. doi: 10.1371/journal.pone.0334255. eCollection 2025.ABSTRACTBACKGROUND: Hypertension remains one of the primary risk factors for cardiovascular disease and the leading cause of mortality worldwide. According to the World Health Organization (WHO), as estimated
PLoS One. 2025 Oct 29;20(10):e0332226. doi: 10.1371/journal.pone.0332226. eCollection 2025.ABSTRACTBACKGROUND: Hypertension is a significant public health concern globally and in India, contributing substantially to the burden of cardiovascular diseases. Early detection through appropriate screening
ACS Appl Mater Interfaces. 2025 Oct 29. doi: 10.1021/acsami.5c18435. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is a highly prevalent condition that is associated with an increased burden of cardiovascular diseases and mortality. Between 7% and 12% of the general population are affec
J Alzheimers Dis. 2025 Oct 29:13872877251389985. doi: 10.1177/13872877251389985. Online ahead of print.ABSTRACTBackgroundWith increasing life expectancy, more individuals will face age-related cognitive difficulties, including Alzheimer's disease. It is, therefore, important to identify early, poten
J Alzheimers Dis. 2025 Oct 29:13872877251390562. doi: 10.1177/13872877251390562. Online ahead of print.ABSTRACTBackgroundAccurate and accessible risk assessment tools are essential for effective dementia management. The Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) model is t
CONCLUSION: Berzosertib 270 mg/m² and irinotecan 180 mg/m² was the RP2D. The combination is associated with manageable side effects and promising disease activity in ATM mutant solid tumors.Cancer. 2025 Nov 1;131(21):e70157. doi: 10.1002/cncr.70157.ABSTRACTBACKGROUND: Ataxia telangiectasia and Rad3-
