In Silico Clinical Trials in Drug Development: A Systematic Review

Ther Innov Regul Sci. 2025 Nov 24. doi: 10.1007/s43441-025-00893-w. Online ahead of print.ABSTRACTIn the context of clinical research, computational models have received increasing attention over the past decades. In this systematic review, we aimed to provide an overview of the role of so-called in

B Bohua Chen

Impact of subthreshold troponin levels and temporal trends on short term adverse cardiovascular outcomes in patients discharged from the emergency department: a RACE-IT trial substudy

Clin Res Cardiol. 2025 Nov 24. doi: 10.1007/s00392-025-02789-z. Online ahead of print.ABSTRACTBACKGROUND: High-sensitivity cardiac troponin I assays enable early exclusion of myocardial infarction in the emergency department. However, the clinical implications of detectable troponin values below the

M Muhammad Ahmad Qureshi

Dual Disease Burden: Growing Older with Congenital Heart Disease and Hereditary Metabolic and Connective Tissue Disorders-Data from the PATHFINDER-CHD Registry on Heart Failure

Geriatrics (Basel). 2025 Nov 20;10(6):152. doi: 10.3390/geriatrics10060152.ABSTRACTBackground: Advances in diagnosis and treatment have led to a growing population of adults with congenital heart disease (ACHD). Despite increasing life expectancy, their clinical needs-especially in older age-remain

A Ann-Sophie Kaemmerer-Suleiman