BMJ Open. 2026 Apr 16;16(4):e103702. doi: 10.1136/bmjopen-2025-103702.ABSTRACTOBJECTIVE: Heart failure (HF) is a major public health issue due to its high morbidity, mortality and healthcare burden. This study aimed to provide estimates of HF incidence, survival rates, outcome changes and their pred
Eur J Pharmacol. 2026 Apr 14:178873. doi: 10.1016/j.ejphar.2026.178873. Online ahead of print.ABSTRACTObesity is associated with low circulating IGF-1 levels, mitochondrial injury, and myocardial anomalies, however, the precise interplay between IGF-1 and obesity cardiomyopathy remains unclear. Our
J Glob Health. 2026 Apr 17;16:04110. doi: 10.7189/jogh.16.04110.ABSTRACTBACKGROUND: Ambient temperature is a key environmental factor influencing cardiovascular health. In patients with atrial fibrillation (AF), seasonal variations may affect the risk of clinical events and mortality. We aimed to as
J Glob Health. 2026 Apr 17;16:04155. doi: 10.7189/jogh.16.04155.ABSTRACTBACKGROUND: Peripheral artery disease (PAD), a common atherosclerotic condition characterised by the narrowing or obstruction of peripheral arteries, has become a substantial public health concern in China. However, its prevalen
J Med Food. 2026 Apr 16:1096620X261438295. doi: 10.1177/1096620X261438295. Online ahead of print.ABSTRACTHypercholesterolemia is a major risk factor for cardiovascular disease, necessitating the development of effective and safe lipid-lowering interventions. This study evaluated the antihypercholest
J Cardiovasc Pharmacol Ther. 2026 Jan-Dec;31:10742484261440344. doi: 10.1177/10742484261440344. Epub 2026 Apr 16.ABSTRACTDespite significant advances in the management of myocardial infarction (MI), therapeutic options targeting upstream pathogenic mechanisms remain scarce. This study introduces a n
BackgroundDual antiplatelet therapy (DAPT) with aspirin and potent P2Y(12) inhibitors such as ticagrelor effectively reduces ischemic events but increases bleeding risk. In patients requiring long-term DAPT, switching from ticagrelor to a thienopyridine is often considered to reduce bleeding risk or
Ned Tijdschr Geneeskd. 2026 Apr 15;170:D8798.ABSTRACTA patent foramen ovale (PFO) is present in approximately 25-30% of adults and is usually asymptomatic. However, under conditions of elevated right heart pressure, a PFO can enable right-to-left shunting, allowing venous thrombi to enter the arteri
Eur Heart J. 2026 Apr 16:ehag176. doi: 10.1093/eurheartj/ehag176. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Low-density lipoprotein cholesterol (LDL-C)-lowering therapies are proven effective in atherosclerotic cardiovascular disease (ASCVD), but real-world evidence for proprotein convertas
JACC Case Rep. 2026 Apr 15;31(15):107160. doi: 10.1016/j.jaccas.2026.107160.ABSTRACTBACKGROUND: This study aimed to explore the clinical application of renal denervation (RDN) in patients with refractory hypertension complicated by acute aortic syndrome.CASE SUMMARY: We present a case of a 54-year-o
J Neurochem. 2026 Apr;170(4):e70430. doi: 10.1111/jnc.70430.ABSTRACTIschemic stroke results in sudden blood flow cessation, thus unmet energy requirements. Glycogen stored around peri-microvascular astrocyte end-feet may mediate capillary contractility and cerebral blood flow alterations. Under gluc
J Int Assoc Provid AIDS Care. 2026 Jan-Dec;25:23259582261444131. doi: 10.1177/23259582261444131. Epub 2026 Apr 16.ABSTRACTIntroductionHypertension has emerged as a significant comorbidity among people living with Human Immunodeficiency Virus (HIV). However, the prevalence and determinants of hyperte
Sci Prog. 2026 Apr-Jun;109(2):368504261444470. doi: 10.1177/00368504261444470. Epub 2026 Apr 16.ABSTRACTObjectiveThis study investigates the association between dietary live microbial intake and mortality among obese adults.MethodsFrom the 1999-2018 cycles of the U.S. National Health and Nutrition E
Clin Cardiol. 2026 Apr;49(4):e70304. doi: 10.1002/clc.70304.ABSTRACTOBJECTIVE: The C-reactive protein-triglyceride-glucose index (CTI) reflects systemic inflammation and insulin resistance, but its relationship with coronary artery calcium (CAC) progression remains unclear. This study examined the a
J Am Heart Assoc. 2026 Apr 16:e045304. doi: 10.1161/JAHA.125.045304. Online ahead of print.ABSTRACTBACKGROUND: High salt (HS) intake is a known cardiovascular risk factor, yet the mechanisms linking salt intake to endothelial dysfunction remain unclear. We investigated whether HS induces vascular se
J Am Heart Assoc. 2026 Apr 16:e045947. doi: 10.1161/JAHA.125.045947. Online ahead of print.ABSTRACTBACKGROUND: Cognitive impairment and dementia are common in patients with heart failure, but the relationships between left ventricular (LV) function, cerebral small vessel disease (CSVD), and cognitio
J Am Heart Assoc. 2026 Apr 16:e040875. doi: 10.1161/JAHA.124.040875. Online ahead of print.ABSTRACTBACKGROUND: Upper gastrointestinal bleeding is a severe postoperative complication after coronary artery bypass grafting. We aimed to identify the incidence, predictors, and outcomes of nonvariceal upp
J Am Heart Assoc. 2026 Apr 16:e046180. doi: 10.1161/JAHA.125.046180. Online ahead of print.ABSTRACTBACKGROUND: As transcatheter aortic valve replacement (TAVR) expands to younger, lower-risk populations, the need for repeat procedures due to valve degeneration is expected to increase. TAVR-in-TAVR h
J Rehabil Med. 2026 Apr 16;58:jrm45503. doi: 10.2340/jrm.v58.45503.ABSTRACTOBJECTIVE: To examine whether early multidimensional mobility assessments discriminate independent ambulation and functional independence on discharge in subacute stroke inpatients with supervised walking ability.DESIGN: Retr
J Am Heart Assoc. 2026 Apr 16:e045788. doi: 10.1161/JAHA.125.045788. Online ahead of print.ABSTRACTBACKGROUND: An effective antithrombotic strategy for patients with univentricular heart is required. We determined the prevalence of antithrombotic treatment and survival in patients with Fontan circul
J Am Heart Assoc. 2026 Apr 16:e050147. doi: 10.1161/JAHA.126.050147. Online ahead of print.ABSTRACTNonvalvular cardiovascular device infections, although rare in most cases, represent substantial clinical challenges due to their life-threatening potential and diagnostic complexity. Although infectio
Eur J Endocrinol. 2026 Apr 16:lvag062. doi: 10.1093/ejendo/lvag062. Online ahead of print.ABSTRACTGlucocorticoid withdrawal syndrome (GWS) is a frequent and clinically significant consequence of reducing chronic endogenous or exogenous glucocorticoid exposure. The syndrome presents with a range of s
Portable air cleaners (PACs) can reduce blood pressure (BP) by decreasing fine particulate matter (PM(2.5)) air pollution exposure. However, the effectiveness of a single PAC in a bedroom and the impact on self-measured home BPs over 4 weeks have not been evaluated. We conducted a randomized-order d
Haemophilia. 2026 Apr 16. doi: 10.1111/hae.70274. Online ahead of print.ABSTRACTInherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitativ
