Time-series analysis of vitiligo-related online search behavior in response to ambient air pollutants

Sci Rep. 2025 Dec 12. doi: 10.1038/s41598-025-31422-2. Online ahead of print.ABSTRACTAmbient air pollutants are hazardous materials posing significant risks to global public health. While their impacts on respiratory and cardiovascular systems are well-established, their role in triggering specific

S Shijie Zhu

Sleep quality in Spanish adults: an age- and sex-stratified cross-sectional study

Sci Rep. 2025 Dec 12;15(1):43670. doi: 10.1038/s41598-025-27418-7.ABSTRACTPoor sleep quality is associated with obesity, cardiovascular disease, cognitive impairment, increased hospitalization and mortality. Combining actigraphy with questionnaires effectively evaluates sleep. Age and sex shape both

C César Jiménez-Vaquero

Combined triglyceride-glucose index and systemic inflammation response index are associated with coronary artery stenosis severity in acute coronary syndrome: a retrospective cohort study

Eur J Med Res. 2025 Dec 12. doi: 10.1186/s40001-025-03650-9. Online ahead of print.ABSTRACTBACKGROUND: Early identification of high-risk individuals for coronary artery disease (CAD) is critical, especially in acute coronary syndrome (ACS) patients who face elevated risks of adverse cardiovascular e

Y Yangfeng Xie

Association between systemic inflammation and risk of atrial fibrillation in cancer survivors: a population-based cohort study using UK biobank

Cardiooncology. 2025 Dec 12. doi: 10.1186/s40959-025-00414-6. Online ahead of print.ABSTRACTBACKGROUND: Cancer survivors (CSs) are at increased risk of atrial fibrillation (AF), potentially due to cancer-related inflammation and treatment effects. While inflammation has been implicated in both cance

Q Quan Yang

Peripheral blood myeloid-to-lymphoid ratio: a novel indicator for assessing renal and cardiovascular risks in chronic kidney disease patients-a multicenter longitudinal investigation

Eur J Med Res. 2025 Dec 12. doi: 10.1186/s40001-025-03668-z. Online ahead of print.ABSTRACTBACKGROUND: The myeloid-to-lymphoid ratio (MLR) has been associated with adverse outcomes in various clinical settings; however, its prognostic significance in chronic kidney disease (CKD) remains to be elucid

J Jiachuan Xiong

Assessing the impact of bariatric surgery on cardiovascular risk in type 2 diabetes: a systematic review and meta-analysis using OMICs data

Diabetol Metab Syndr. 2025 Dec 12;17(1):448. doi: 10.1186/s13098-025-02002-1.ABSTRACTType 2 diabetes (T2D) is a complex, multifactorial metabolic disorder, and while bariatric surgery has emerged as a promising intervention for obesity-related T2D with significant metabolic benefits, its long-term d

B Balqees Almazrouei

Targeting ATR offers multifaceted treatment strategies involving RAD51-mediated compensatory DNA repair in bladder cancer

No abstractJ Exp Clin Cancer Res. 2025 Dec 12. doi: 10.1186/s13046-025-03603-4. Online ahead of print.NO ABSTRACTPMID:41387887 | DOI:10.1186/s13046-025-03603-4

J Julia Pannhausen

Soluble RAGE further stratifies risk of coronary artery and end-stage kidney disease in high-risk individuals with type 1 diabetes and treatment-resistant hypertension

Cardiovasc Diabetol. 2025 Dec 12. doi: 10.1186/s12933-025-03017-8. Online ahead of print.ABSTRACTBACKGROUND: Soluble receptor for advanced glycation end-products (sRAGE) modulates RAGE-mediated inflammation and oxidative stress. We investigated if sRAGE stratifies cardiovascular and kidney disease r

K Krishna Adeshara

Genetic profiling of the circulating proteome in common diseases suggests causal proteins and improves risk prediction

Nat Commun. 2025 Dec 12. doi: 10.1038/s41467-025-67238-x. Online ahead of print.ABSTRACTElucidating the genetic regulation of protein expression in specific disease states is important for understanding how genetic variation impact disease pathology. To this end, we conduct a large-scale genome-prot

Q Qianying Ma

Plasma proteomic profiles identify biomarkers predicting Crohn's disease up to 16 years before onset

Nat Commun. 2025 Dec 12. doi: 10.1038/s41467-025-66483-4. Online ahead of print.ABSTRACTReliable tools for early identification of Crohn's disease (CD) remain lacking. We analyzed 2736 plasma proteins in 39,634 UK Biobank (UKB) participants and identified 44 associated with incident CD. CD274, CHI3L

J Jing Feng

A unified multi-task learning framework for automated assessment of left ventricular structure and its systolic function from echocardiography

No abstractSci Rep. 2025 Dec 12. doi: 10.1038/s41598-025-31773-w. Online ahead of print.NO ABSTRACTPMID:41387528 | DOI:10.1038/s41598-025-31773-w

Z Zeinab Khodaverdian

Numerical simulations of blood flow in a stenosed artery using a multi-criteria decision-making Algorithm

Sci Rep. 2025 Dec 12. doi: 10.1038/s41598-025-31493-1. Online ahead of print.ABSTRACTThe hemodynamic characteristics of blood flow through a stenosed artery are analyzed in this study. A two-dimensional computational model is developed to simulate the behavior of a hybrid micropolar-Casson fluid flo

M Muhammad Umar

Greater exposure to PM2.5 and PM10 is associated with a higher BAD score: the Maastricht study

Sci Rep. 2025 Dec 12;15(1):43694. doi: 10.1038/s41598-025-27471-2.ABSTRACTTo investigate the associations between exposure to ambient air pollutants and the Belin/Ambrosio Enhanced Ectasia score (BAD score), a tomographic parameter for identifying corneas at risk for ectasia. This prospective cross-

M Magali M S Vandevenne

Effect of posture on photoplethysmography signals from the posterior tibial artery in adults with and without type 2 diabetes

Sci Rep. 2025 Dec 12;15(1):43737. doi: 10.1038/s41598-025-28223-y.ABSTRACTDiabetic foot complications remain a major cause of disability in diabetes and represent a severe consequence of poor glycaemic control, primarily driven by peripheral arterial obstruction, neuropathic damage, and compromised

A Apakrita Tayade

DNA methylation predicts adverse outcomes of coronary artery disease

Nat Commun. 2025 Dec 12. doi: 10.1038/s41467-025-66204-x. Online ahead of print.ABSTRACTAdverse outcomes including myocardial infarction (MI) and stroke render coronary artery disease (CAD) a leading cause of death worldwide. DNA methylation markers may alert such adversity ahead of the events. We p

M Min Qin

Impact of High-Fat Diet on Biochemical Changes Following Experimental Myocardial Infarction

J Cell Mol Med. 2025 Dec;29(23):e70984. doi: 10.1111/jcmm.70984.ABSTRACTMyocardial infarction (MI) is a sudden necrosis of cardiomyocytes, often caused by atherosclerosis, with obesity being a significant risk factor. This study aimed to evaluate the effects of a high-fat diet (HFD) on post-MI myoca

K Katarina Bujnova

Adipose Tissue Circadian Clocks: Implications for Metabolism and Metabolic Dysfunction

Obes Rev. 2025 Dec 12:e70071. doi: 10.1111/obr.70071. Online ahead of print.ABSTRACTAdipose tissue, beyond its role as a fat storage depot, functions as an endocrine organ, secreting signaling molecules systemically and via paracrine mechanisms (particularly in perivascular and ectopic fat). These d

P Peiyuan Zeng

Efficacy and safety of novel lipoprotein(a)-targeted therapies: A systematic review and meta-analysis of randomised controlled trials

No abstractDiabetes Obes Metab. 2025 Dec 12. doi: 10.1111/dom.70349. Online ahead of print.NO ABSTRACTPMID:41387345 | DOI:10.1111/dom.70349

A Anisio Uchoa Leite Santana

Proteome-Wide Mendelian Randomization Implicates Shared Necroptosis-Ferroptosis Effectors in Causal Pathways of Multiple Sclerosis Susceptibility

Ann N Y Acad Sci. 2025 Dec 12. doi: 10.1111/nyas.70162. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is a chronic neurodegenerative disorder for which dysregulated ferroptosis and necroptosis have demonstrated pathological associations but these lack causal validation in disease susceptibil

W Wu Yan

Evaluation of Data Sources for Critical Congenital Heart Defect Case Ascertainment in North Carolina

Birth Defects Res. 2025 Dec;117(12):e70005. doi: 10.1002/bdr2.70005.ABSTRACTBACKGROUND: Surveillance of critical congenital heart defects (CCHDs) is important for research and public health practice. The recent implementation of universal pulse oximetry (POX) screening may provide an additional reso

H Helen Atkinson

Upregulated Calcium Sensing Receptor Mediates Pulmonary Venous Remodeling in Pulmonary Hypertension

Acta Physiol (Oxf). 2026 Jan;242(1):e70142. doi: 10.1111/apha.70142.ABSTRACTAIM: The mechanism of pulmonary venous remodeling (PVR) remains unclear. We tested the role of the calcium sensing receptor (CaSR) in PVR in pulmonary hypertension (PH).METHODS: PVR was investigated in two PH models, monocro

Q Qiudi Mo

Angiographic phenotypes predict FFR/iFR discordance in severe aortic stenosis: A cluster analysis

Cardiovasc Revasc Med. 2025 Dec 10:S1553-8389(25)00609-8. doi: 10.1016/j.carrev.2025.12.004. Online ahead of print.ABSTRACTBACKGROUND: Assessing coronary artery disease in severe aortic stenosis (AS) is challenging due to altered hemodynamics, causing discordance between fractional flow reserve (FFR

A Artur Dziewierz

The value of patient selection in same-day discharge implementation: insights from MBSAQIP database

Surg Obes Relat Dis. 2025 Nov 10:S1550-7289(25)01022-6. doi: 10.1016/j.soard.2025.10.016. Online ahead of print.ABSTRACTBACKGROUND: Same-day discharge (SDD) in sleeve gastrectomy (SG) is becoming increasingly common but requires careful patient selection.OBJECTIVES: To evaluate the risk profile of p

S Sara Saeidishahri

Bone mineral density as a mediator in the association of abdominal aortic calcification with mortality among the general population aged over 50

Nutr Metab Cardiovasc Dis. 2025 Nov 6:104431. doi: 10.1016/j.numecd.2025.104431. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: The prevalence of vascular calcification and osteoporosis is increasing in the general population. We aimed to investigate the combined impact of abdominal aortic calci

Y Yujuan Yuan