Clin J Am Soc Nephrol. 2026 Jan 26. doi: 10.2215/CJN.0000000994. Online ahead of print.ABSTRACTBACKGROUND: We recently developed and validated a hierarchical composite endpoint (HCE) for chronic kidney disease (CKD) progression combining time-to-event kidney outcomes with the rate of estimated glome
Blood. 2026 Jan 26:blood.2025029834. doi: 10.1182/blood.2025029834. Online ahead of print.ABSTRACTPlasminogen activator inhibitor 1 (PAI-1) is an inhibitor of fibrinolysis, thereby promoting blood clot stabilization. PAI-1 contributes to thrombosis, diet-induced obesity, and age-associated diseases
JAMA Intern Med. 2026 Jan 26. doi: 10.1001/jamainternmed.2025.7453. Online ahead of print.ABSTRACTIMPORTANCE: Gout is associated with increased cardiovascular risk. Whether achieving a target serum urate level lower than 6 mg/dL with urate-lowering treatment (ULT) would reduce cardiovascular risk in
Hepatol Res. 2026 Jan 26. doi: 10.1111/hepr.70127. Online ahead of print.ABSTRACTAIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by the presence of hepatic steatosis and at least one of five cardiometabolic risk factors, leading to the development of cardiovas
Sci China Life Sci. 2026 Jan 15. doi: 10.1007/s11427-025-3187-4. Online ahead of print.ABSTRACTElevated blood low-density lipoprotein (LDL) levels are a major risk factor for cardiovascular disease. Increasing LDL receptor (LDLR) expression effectively reduces blood LDL and serves as a key therapeut
CVIR Endovasc. 2026 Jan 26;9(1):10. doi: 10.1186/s42155-026-00655-1.ABSTRACTBACKGROUND: Endovascular therapy (EVT) for aortoiliac (AI) disease has shown favorable outcomes with recent advances in technology. Furthermore, the transradial approach (TRA) has emerged as a less invasive alternative to tr
Phys Eng Sci Med. 2026 Jan 26. doi: 10.1007/s13246-026-01699-2. Online ahead of print.ABSTRACTCongestive heart failure (CHF) is a cardiovascular disease that poses a serious threat to human health. Electrocardiogram (ECG) signals can be used to detect heart diseases such as CHF. However, the low amp
Eur Radiol Exp. 2026 Jan 26;10(1):7. doi: 10.1186/s41747-025-00671-1.ABSTRACTArtificial intelligence (AI) and large language models (LLMs) are increasingly integrated into radiology, offering new possibilities for advanced imaging techniques, including cardiovascular magnetic resonance (CMR). This p
Insights Imaging. 2026 Jan 26;17(1):19. doi: 10.1186/s13244-025-02190-4.ABSTRACTBACKGROUND: Recent PET studies suggest a link between amygdala activity and cardiovascular disease. Altered amygdala volumes are associated with increased stressor-evoked cardiovascular reactivity, which potentially incr
Mol Neurobiol. 2026 Jan 26;63(1):396. doi: 10.1007/s12035-026-05693-3.ABSTRACTWhile epidemiological studies have linked cardiovascular disease (CVD) and amyotrophic lateral sclerosis (ALS), the causal pathways remain unclear. This study aims to clarify the causal relationship between CVD and ALS, wi
Ann Hematol. 2026 Jan 26;105(2):62. doi: 10.1007/s00277-026-06839-y.ABSTRACTWe aimed to summarize the clinical characteristics of children diagnosed with acute leukemia (AL) and analyze the risk factors associated with early mortality occurring within 6 weeks of diagnosis. This study aimed to identi
Support Care Cancer. 2026 Jan 26;34(2):127. doi: 10.1007/s00520-026-10353-2.ABSTRACTPURPOSE: Venous thromboembolism (VTE) represents a significant complication in pancreatic cancer patients, impacting both mortality and quality of life. Understanding research trends and developments in this field is
J Gen Intern Med. 2026 Jan 26. doi: 10.1007/s11606-026-10171-6. Online ahead of print.ABSTRACTBACKGROUND: Ohio ranks among the highest US states for cardiovascular disease (CVD) morbidity and mortality. Although interventions exist for managing CVD risk factors, adoption in primary care is often lim
Eur Radiol Exp. 2026 Jan 26;10(1):6. doi: 10.1186/s41747-025-00673-z.ABSTRACTOBJECTIVE: Abdominal aortic aneurysm (AAA) remains a life-threatening condition with few large-animal disease models. We aimed to develop a fully endovascular porcine AAA model for radiology research, reducing surgical trau
Clin Res Cardiol. 2026 Jan 26. doi: 10.1007/s00392-026-02848-z. Online ahead of print.ABSTRACTBACKGROUND: The efficacy of transthyretin stabilisation in cardiac transthyretin amyloidosis (ATTR-CM) has been demonstrated in a clinical trial setting, but little is known about treatment decision-making
Kardiol Pol. 2026 Jan 26. doi: 10.33963/v.phj.110885. Online ahead of print.ABSTRACTBACKGROUND: High body mass index and abdominal obesity are associated with an increased risk of cardiometabolic diseases.AIMS: We aimed to investigate the prevalence of obesity in 45 591 individuals included in the L
Gut Microbes. 2026 Dec 31;18(1):2617694. doi: 10.1080/19490976.2026.2617694. Epub 2026 Jan 26.ABSTRACTSystemic infections are a common cause of complications and death after stroke. These infections can occur due to the breakdown of the gut epithelial barrier and the translocation of bacteria from t
J Biochem Mol Toxicol. 2026 Feb;40(2):e70714. doi: 10.1002/jbt.70714.ABSTRACTAtherosclerosis is a major cause of cardiovascular diseases, and endothelial cells (ECs) senescence plays a key role in its initiation and progression. This study investigates the function and epigenetic regulatory mechanis
Life Sci. 2025 Dec 1;382:124053. doi: 10.1016/j.lfs.2025.124053. Epub 2025 Oct 25.ABSTRACTBACKGROUND: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host immune response to infection, disrupts intracellular messengers, such as cyclic nucleotides cAMP and cGMP, contributing to
Eur J Psychotraumatol. 2026 Dec;17(1):2605801. doi: 10.1080/20008066.2025.2605801. Epub 2026 Jan 26.ABSTRACTBackground and Objectives: Omega-3 fatty acids have positive effects on mental health. This study aimed to explore the association between plasma omega-3 fatty acid levels and the risk of post
Glob Heart. 2026 Jan 21;21(1):4. doi: 10.5334/gh.1517. eCollection 2026.ABSTRACTBACKGROUND: This study aims to assess the burden of aortic aneurysm (AA) among individuals aged 55 years and older from 1990 to 2021 at global, regional, and national levels.METHODS: Data from the Global Burden of Diseas
Glob Heart. 2026 Jan 16;21(1):2. doi: 10.5334/gh.1511. eCollection 2026.ABSTRACTOBJECTIVE: Progressed medical techniques improved the life expectancy of congenital heart disease (CHD) population. Intellectual developmental disability (IDD) has progressively been a raised concern. This study aimed to
Glob Heart. 2026 Jan 20;21(1):3. doi: 10.5334/gh.1514. eCollection 2026.ABSTRACTNon-communicable diseases (NCDs) account for 70% of global mortality and are responsible for over 38 million deaths annually, with cardiovascular disease (CVD) constituting most of these fatalities. While traditional ris
Front Microbiol. 2026 Jan 9;16:1693472. doi: 10.3389/fmicb.2025.1693472. eCollection 2025.ABSTRACTOBJECTIVE: Wulanwendusu-11 (WLWDS-11) is a commonly used Mongolian medicine for treating cardiovascular diseases. However, its regulating effect on intestinal flora-host metabolism in relieving chronic
