Epigenetic Aging Clocks and Incident Cardiovascular Outcomes: Results From the MESA

J Am Heart Assoc. 2025 Dec 10:e044946. doi: 10.1161/JAHA.125.044946. Online ahead of print.ABSTRACTBACKGROUND: DNA methylation-based aging clocks capture biological aging processes and may improve cardiovascular risk prognostication. However, evidence about epigenetic aging clocks, incident outcomes

S Shantanu Srivatsa

Relations of Artificial Intelligence Vascular Age With Cardiometabolic Disease Progression: The Framingham Heart Study

J Am Heart Assoc. 2025 Dec 10:e044872. doi: 10.1161/JAHA.125.044872. Online ahead of print.ABSTRACTBACKGROUND: Aortic stiffening increases pulsatile power transmission into the microvasculature, resulting in blunted microvascular reactivity, which can impair postprandial nutrient processing and gluc

D David J Hamel-Sellman

Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease

J Am Heart Assoc. 2025 Dec 10:e042610. doi: 10.1161/JAHA.125.042610. Online ahead of print.ABSTRACTBACKGROUND: Estimated pulse wave velocity (ePWV), a noninvasive marker of arterial stiffness, reflects vascular aging and has been associated with increased coronary artery disease (CAD) risk. However,

C Chang Sheng

Unplanned Hospitalization Due to All-Cause Morbidity and Its Real-World Management Practices in Patients With Fontan Circulation

J Am Heart Assoc. 2025 Dec 10:e044374. doi: 10.1161/JAHA.125.044374. Online ahead of print.ABSTRACTBACKGROUND: Management strategies of unplanned hospitalizations (UPH) vary and have not been well characterized in patients with Fontan circulation.METHODS: We prospectively followed 3226 Fontan patien

H Hideo Ohuchi

Ivabradine in the treatment of congenital junctional ectopic tachycardia: a case report and review of the literature

Cardiol Young. 2025 Dec 10:1-5. doi: 10.1017/S1047951125110354. Online ahead of print.ABSTRACTCongenital junctional ectopic tachycardia is a rare arrhythmia that poses significant management challenges. This report presents a case of neonatal-onset congenital junctional ectopic tachycardia treated w

P Peiwen Gong

NADPH Oxidase 4 and Metabolic Stress in Dahl Salt-Sensitive Rat Kidneys

Hypertension. 2025 Dec 10. doi: 10.1161/HYPERTENSIONAHA.125.25718. Online ahead of print.ABSTRACTBACKGROUND: Salt-sensitive (SS) hypertension is associated with oxidative stress and impaired renal metabolism, but the mechanistic link remains unclear. We investigated the role of NOX4 (NADPH oxidase 4

S Satoshi Shimada

Tert Deletion Impairs Circadian Regulation of Blood Pressure in Male Spontaneously Hypertensive Rats

Hypertension. 2025 Dec 10. doi: 10.1161/HYPERTENSIONAHA.125.25510. Online ahead of print.ABSTRACTBACKGROUND: Deletion of the Tert gene leads to telomere shortening, which is associated with aging and age-related cardiovascular disease, but its effects on circadian regulation of blood pressure have n

K Kateryna Semenovykh

S-Nitrosylation of Pyruvate Kinase Isoform 2 Drives Cardiac Fibrosis by Promoting Mitochondrial Fission

Circulation. 2025 Dec 10. doi: 10.1161/CIRCULATIONAHA.125.075903. Online ahead of print.ABSTRACTBACKGROUND: Cardiac fibrosis is a major determinant of adverse clinical outcomes of many heart diseases; currently, therapeutic strategy directly targeting fibroblasts is lacking. Nitric oxide-mediated ni

S Shanshan Luo

Effect of tDCS Concurrent With VR-Based Robotic Intervention on Hemiplegic Upper Limb Function After Subacute Ischemic Stroke: A Randomized Controlled Study

Neural Plast. 2025 Dec 1;2025:8425060. doi: 10.1155/np/8425060. eCollection 2025.ABSTRACTBACKGROUND: Upper limb hemiplegia faces the challenge of slow and difficult recovery. A "closed-loop method" based on brain plasticity has been proposed, combining central and peripheral interventions to enhance

C Chuan Guo

Malondialdehyde-acetaldehyde modified macromolecules and resulting autoantibodies in rheumatoid arthritis pathogenesis: a Systematic Literature Review

Front Immunol. 2025 Nov 24;16:1648290. doi: 10.3389/fimmu.2025.1648290. eCollection 2025.ABSTRACTOBJECTIVE: Substantial progress has been made in understanding the involvement of malondialdehyde-acetaldehyde (MAA) adducts in rheumatoid arthritis (RA) pathogenesis. This systematic review synthesizes

W Wenxian Zhou

Comparative Cardiovascular Safety of Duloxetine and Gabapentin in Patients with Hip Osteoarthritis

J Pain Res. 2025 Dec 3;18:6437-6448. doi: 10.2147/JPR.S557621. eCollection 2025.ABSTRACTOBJECTIVE: Duloxetine, an antidepressant commonly used as a nonopioid analgesic for chronic pain management, has been speculated to increase cardiovascular (CV) complications. This study aims to evaluate the CV a

S Suhyeon Moon

Dose Optimization of Rivaroxaban in Elderly Chinese Patients with Non-Valvular Atrial Fibrillation: Analysis of Populations Pharmacokinetics and Exposure-Response Relationships

Drug Des Devel Ther. 2025 Dec 3;19:10703-10717. doi: 10.2147/DDDT.S563521. eCollection 2025.ABSTRACTPURPOSE: This study aimed to develop a population pharmacokinetic (PopPK) model in elderly Chinese patient with NVAF, characterize the pharmacokinetic variability, identify relevant covariates affecti

T Tian-Yu Li

Validation of in Vivo Myocardial Strain with PET Derived Feature Tracking: Direct Comparison with Tagging-Cine Magnetic Resonance

Ann Nucl Cardiol. 2025;11(1):26-32. doi: 10.17996/anc.25-00002. Epub 2025 Oct 31.ABSTRACTPurpose: The aim of this study was to validate positron emission tomography feature tracking (PETFT) for assessing endocardial wall strain by comparing it with conventional tagging-cine magnetic resonance (MR) d

M Masataka Katahira

Evaluation of the Usefulness of the Myocardial Flow Reserve Index Using an Anger-Type SPECT/CT System

Ann Nucl Cardiol. 2025;11(1):13-19. doi: 10.17996/anc.24-00005. Epub 2025 Oct 31.ABSTRACTBackground: The quantitative analysis of myocardial blood flow and myocardial flow reserve (MFR) is expected to address challenges in evaluating the relative distribution of myocardial perfusion imaging. This st

A Atsushi Komuro

Nuclear Medicine Imaging for the Diagnosis of ATTR Cardiac Amyloidosis: Report of Japanese Society of Nuclear Cardiology Working Group

No abstractAnn Nucl Cardiol. 2025;11(1):3-12. doi: 10.17996/anc.25-001. Epub 2025 Oct 31.NO ABSTRACTPMID:41368559 | PMC:PMC12683091 | DOI:10.17996/anc.25-001

T Takashi Kudo

Diagnostic Principle with Washout Rate of 123I-β-methyl-p-iodophenyl pentadecanoic Acid for Triglyceride Deposit Cardiomyovasculopathy

Ann Nucl Cardiol. 2025;11(1):39-41. doi: 10.17996/anc.25-00003. Epub 2025 Oct 31.ABSTRACTTriglyceride deposit cardiomyovasculopathy (TGCV) (Orphanet ORPHA code: 692305) is an emerging rare adult-onset cardiovascular disease, first identified in Japan. In TGCV, defective intracellular lipolysis of lo

K Ken-Ichi Hirano

Visual Differentiation Between Triglyceride Deposit Cardiomyovasculopathy and Old Myocardial Infarction Using Count-Washout Rate Polar Map in Iodine-123-β-Methyl-p-Iodophenyl-Pentadecanoic Acid Scintigraphy

Ann Nucl Cardiol. 2025;11(1):20-25. doi: 10.17996/anc.24-00012. Epub 2025 Oct 31.ABSTRACTBackground: In nuclear cardiology, tracer uptake and washout rate (WR) are key parameters for evaluating cardiac pathophysiology. However, WR is influenced by counts in the early image, making it difficult to ev

R Ryohei Ono

QTc Interval and Its Associated Factors in Patient With Type 2 Diabetic Mellites

J Diabetes Res. 2025 Dec 1;2025:8664620. doi: 10.1155/jdr/8664620. eCollection 2025.ABSTRACTINTRODUCTION: There is a notable link between diabetes mellitus (DM) and cardiovascular diseases (CVDs), particularly abnormal ventricular repolarization marked by a prolonged QT interval, which significantly

D Deresse Sinamaw Asmare

Surgical outcomes of cardiac fibroma in children: Early results

JTCVS Tech. 2025 Sep 10;34:185-190. doi: 10.1016/j.xjtc.2025.08.019. eCollection 2025 Dec.ABSTRACTOBJECTIVE: To describe our surgical techniques and early outcomes after resection of cardiac fibromas in symptomatic children.METHODS: A retrospective analysis was performed including all patients who u

A Arun Beeman

The weeping graft: Severe fluid loss from a polytetrafluoroethylene graft in a patient with congenital cardiac disease with a single-ventricle assist device

No abstractJTCVS Tech. 2025 Oct 4;34:182-184. doi: 10.1016/j.xjtc.2025.08.029. eCollection 2025 Dec.NO ABSTRACTPMID:41368417 | PMC:PMC12683031 | DOI:10.1016/j.xjtc.2025.08.029

S Stephan J Wu

Aortoesophageal fistula: Long-term survival with aggressive multidisciplinary management

JTCVS Tech. 2025 Sep 25;34:1-11. doi: 10.1016/j.xjtc.2025.09.012. eCollection 2025 Dec.ABSTRACTOBJECTIVE: Aortoesophageal fistula (AoEF) is a rare but complex problem that carries high mortality. This study describes our institutional experience with the management of AoEF.METHODS: There were 17 pat

R Rolando Calderon-Rojas

Biomimetic dynamic nanomedicine SrHCF: Lattice self-reconstruction based on Fe2+ response to achieve synergistic "ferrous chelation-antioxidation-calcium antagonism-inflammation inhibition" quadruple treatment of CIRI

Bioact Mater. 2025 Sep 12;55:23-41. doi: 10.1016/j.bioactmat.2025.08.030. eCollection 2026 Jan.ABSTRACTRevascularization has revolutionized the treatment of ischemic stroke (IS), but its efficacy is limited by cerebral ischemia-reperfusion injury (CIRI). CIRI involves the dynamic interaction of mult

T Tingli Xiong

Interferon-induced transmembrane proteins as biomarkers for assessing the diagnosis and severity of coronary artery disease and acute myocardial infarction

Front Med (Lausanne). 2025 Nov 24;12:1645725. doi: 10.3389/fmed.2025.1645725. eCollection 2025.ABSTRACTBACKGROUD: Biomarker discovery remains pivotal for improving coronary artery disease (CAD) and acute myocardial infraction (AMI) diagnosis. While interferon-induced transmembrane proteins (IFITM1/2

Q Qingyan Huang

Emerging Role of Enzyme-Immobilized Nanocarriers in Osteoporosis: Advances and Challenges

Int J Nanomedicine. 2025 Dec 3;20:14457-14479. doi: 10.2147/IJN.S557453. eCollection 2025.ABSTRACTOsteoporosis (OP) is a common bone disease that involves low bone mass and high risk of fracture mainly in older men and women and perimenopausal years. Although conventional therapies provide good ther

N Nie Tang