ADAM17 and its proteolytic targets in disease pathogenesis

FEBS J. 2026 Mar 23. doi: 10.1111/febs.70516. Online ahead of print.ABSTRACTADAM17, from the disintegrin and metalloproteinase (ADAM) family, also called tumor necrosis factor converting enzyme (TACE), is a pleiotropic protease with more than 90 substrates, including growth factors, cytokines, recep

A Abdulbasit Amin

Targeted Delivery of Nucleic Acid Therapeutics: Emerging Carriers and Applications in Common Metabolic and Inflammatory Diseases

Int J Nanomedicine. 2026 Jan 15;21:566642. doi: 10.2147/IJN.S566642. eCollection 2026.ABSTRACTRecent advances in genomics and molecular biology have accelerated the development of nucleic acid-based therapeutics. To optimize their clinical efficacy, various delivery systems-including lipid nanoparti

X Xiyuan Lin

A Self-Assembling Nanomodulator for Synergistic Therapy of Intracerebral Hemorrhage

Int J Nanomedicine. 2026 Mar 16;21:590652. doi: 10.2147/IJN.S590652. eCollection 2026.ABSTRACTINTRODUCTION: Intracerebral hemorrhage (ICH) has high mortality and morbidity due to a complex secondary injury phase driven by oxidative stress and excessive inflammation. Given the limited efficacy of sin

T Tian Yun

Genetic determinants of arterial thrombosis in primary antiphospholipid syndrome: a systematic review

Front Immunol. 2026 Mar 5;17:1761613. doi: 10.3389/fimmu.2026.1761613. eCollection 2026.ABSTRACTBACKGROUND: Primary Antiphospholipid Syndrome (PAPS) is a systemic autoimmune disorder characterized by arterial and/or venous thrombosis and obstetric morbidity. Arterial thrombosis, although less freque

C Claudia Gavris

The impact of chronic comorbidities on cancer immunoediting: challenges and opportunities for immunotherapies

Front Immunol. 2026 Mar 6;17:1773872. doi: 10.3389/fimmu.2026.1773872. eCollection 2026.ABSTRACTImmune surveillance is a central function of the immune system that prevents tumor initiation and progression. This process depends on the coordinated activity of innate and adaptive immune responses to r

K Kassandra Ofelia Rodríguez-Aguillón

Interactions between neutrophil extracellular traps and macrophages: the key to inflammatory diseases

Front Immunol. 2026 Mar 6;17:1731687. doi: 10.3389/fimmu.2026.1731687. eCollection 2026.ABSTRACTInteractions between neutrophil extracellular traps (NETs) and macrophages play a critical role in the initiation and progression of inflammatory diseases. NETs regulate macrophage polarization and functi

X Xiaoyu Shan

RNA sequencing-derived gene co-expression and drug-gene interaction analysis reveal STAT1 as a potential therapeutic target in thrombotic antiphospholipid syndrome

Front Immunol. 2026 Mar 5;17:1741872. doi: 10.3389/fimmu.2026.1741872. eCollection 2026.ABSTRACTOBJECTIVE: Thrombotic primary antiphospholipid syndrome (PAPS) pathogenesis remains undefined, and recurrent thrombosis may occur despite adequate anticoagulation treatment. Identifying disease-specific m

M Michail Baltsiotis

IFNγ-associated immune-metabolic remodeling is linked to serotonin-kynurenine imbalance and cortical vulnerability in lupus-prone mice

Front Immunol. 2026 Mar 5;17:1740039. doi: 10.3389/fimmu.2026.1740039. eCollection 2026.ABSTRACTINTRODUCTION: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a major clinical challenge, characterized by heterogeneous manifestations and the absence of reliable biomarkers. The mechanisms link

K Karim Matmat

Taking its TOLL: the role of toll-like receptor 4 in human health and disease, and its potential as a therapeutic target

Front Immunol. 2026 Mar 5;17:1761361. doi: 10.3389/fimmu.2026.1761361. eCollection 2026.ABSTRACTToll-like receptor 4 (TLR4) is a pattern recognition receptor that binds to pathogen associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs). Binding of exogenous or endogen

P Phoebe Crammond

Aquaporin-4 suppresses neuronal pyroptosis after ischemic stroke via the IκBα/NF-κB signaling pathway

Front Immunol. 2026 Mar 6;17:1778802. doi: 10.3389/fimmu.2026.1778802. eCollection 2026.ABSTRACTBACKGROUND: Ischemic stroke, a predominant cause of global mortality and disability, involves complex pathophysiological processes where neuroinflammation and pyroptosis play a crucial role. We aimed to i

H Heling Chu

Risks of Myocardial Infarction and Mortality in Patients with Incident Rheumatoid Arthritis Compared with a Matched General Population: A Danish Nationwide Cohort Study

Clin Epidemiol. 2026 Jan 24;18:568967. doi: 10.2147/CLEP.S568967. eCollection 2026.ABSTRACTBACKGROUND AND AIMS: Rheumatoid arthritis (RA) is increasingly being recognized as cardiovascular risk factor. We examined temporal trends in the risks of myocardial infarction (MI) and all-cause mortality in

B Brian Bridal Løgstrup

Brown Tumor in a Patient With End-Stage Renal Disease: A Case Report of Secondary Hyperparathyroidism Complications

Cureus. 2026 Feb 17;18(2):e103787. doi: 10.7759/cureus.103787. eCollection 2026 Feb.ABSTRACTThe development of a brown tumor is a rare complication of secondary hyperparathyroidism, particularly in patients with chronic kidney disease. Despite advances in the treatment and management of secondary hy

A Ahdadi Ahmed

RNA-Based Therapies for Hypercholesterolemia and Coronary Artery Disease

Cureus. 2026 Feb 18;18(2):e103877. doi: 10.7759/cureus.103877. eCollection 2026 Feb.ABSTRACTRNA-based therapies have emerged as a transformative approach in the management of hypercholesterolemia and coronary artery disease by directly targeting molecular pathways involved in lipid regulation. These

M Maynor Jose Lopez Mendoza

Integrated Management Strategies for Diabetes Mellitus and Hypertension: A Systematic Review

Cureus. 2026 Feb 19;18(2):e103893. doi: 10.7759/cureus.103893. eCollection 2026 Feb.ABSTRACTDiabetes mellitus (DM) and hypertension frequently coexist and together substantially increase the risk of cardiovascular morbidity, mortality, and healthcare burden worldwide. Despite growing recognition of

A Amit Nampalliwar

MINOCA (Myocardial Infarction With Non-obstructive Coronary Arteries) Due to Diffuse Coronary Microvascular Dysfunction in a Patient With Systemic Autoimmune Disease and Chronic Kidney Disease

Cureus. 2026 Feb 18;18(2):e103816. doi: 10.7759/cureus.103816. eCollection 2026 Feb.ABSTRACTMyocardial infarction with non-obstructive coronary arteries (MINOCA) represents a heterogeneous entity requiring systematic exclusion of alternative diagnoses and identification of the underlying mechanism.

T Teenu Kamboj

Age at Menarche and Its Association with Cardiovascular Disease in Women with Childhood-Onset Type 1 Diabetes (T1D)

Diabetes Metab Syndr Obes. 2026 Jan 20;19:579879. doi: 10.2147/DMSO.S579879. eCollection 2026.ABSTRACTOBJECTIVE: Early and delayed menarche are associated with increased cardiovascular disease (CVD) risk in the general population, but data are limited in type 1 diabetes (T1D). We thus examined the r

J Jinghui Ju

Diabetes associated pericyte metabolic signatures and pathogenesis of diabetic retinopathy

Front Endocrinol (Lausanne). 2026 Mar 6;17:1771836. doi: 10.3389/fendo.2026.1771836. eCollection 2026.ABSTRACTPericytes are metabolically active perivascular supporting cells. They are essential for establishing and maintaining the inner blood retinal barrier and retinal neurovascular homeostasis. I

C Casandra Carrillo

Functional analysis from ex-vivo characterization of LDLR exon 13-15 duplication associated to familial hypercholesterolemia

Front Endocrinol (Lausanne). 2026 Mar 6;17:1733372. doi: 10.3389/fendo.2026.1733372. eCollection 2026.ABSTRACTBACKGROUND: Familial hypercholesterolemia (FH) is an inherited semidominant disorder characterized by high plasma cholesterol levels and increased risk of premature cardiovascular disease. M

C Catalina Martínez

The impact of maternal gestational diabetes mellitus on cardiac structural and functional parameters in infants

Front Endocrinol (Lausanne). 2026 Mar 5;17:1701975. doi: 10.3389/fendo.2026.1701975. eCollection 2026.ABSTRACTOBJECTIVE: This study aimed to retrospectively analyze changes in cardiac structural and functional parameters in infants born to mothers with nonpharmacologically managed gestational diabet

Y Yuhong Deng

Association between TyG-related indices and in-hospital acute heart failure in patients with acute myocardial infarction after emergency percutaneous coronary intervention

Front Endocrinol (Lausanne). 2026 Mar 6;17:1798955. doi: 10.3389/fendo.2026.1798955. eCollection 2026.ABSTRACTAIM: Acute heart failure (AHF) may still occur during hospitalization in some patients with acute myocardial infarction (AMI) after emergency percutaneous coronary intervention (PCI). Trigly

R Rong Feng

Age- and diet-dependent progression of retinal microvascular injury in GCK-MODY under metabolic stress

Front Endocrinol (Lausanne). 2026 Mar 6;17:1744691. doi: 10.3389/fendo.2026.1744691. eCollection 2026.ABSTRACTBACKGROUND: Maturity-onset diabetes of the young type 2 (GCK-MODY), caused by heterozygous inactivating mutations in the glucokinase (GCK) gene, is generally considered a mild and stable for

Y Yadi Huang

Correction: Cumulative inflammatory burden of metal mixtures is associated with central obesity, cardiovascular disease, and mortality: findings from NHANES

Front Cell Dev Biol. 2026 Mar 5;14:1817293. doi: 10.3389/fcell.2026.1817293. eCollection 2026.ABSTRACT[This corrects the article DOI: 10.3389/fcell.2026.1717247.].PMID:41869019 | PMC:PMC13000348 | DOI:10.3389/fcell.2026.1817293

F Frontiers Production Office

Bridging innate immunity and iron-dependent death: the interplay between cyclic GMP-AMP synthase-stimulator of interferon genes nexus and ferroptosis in cancer and inflammation

Front Cell Dev Biol. 2026 Mar 6;14:1766502. doi: 10.3389/fcell.2026.1766502. eCollection 2026.ABSTRACTThe cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway and ferroptosis have emerged as fundamental biological mechanisms that converge in regulating cellular homeostasis a

X Xin-Xin Chen

Surgical outcomes and quality of life in octogenarians with early-stage non-small cell lung cancer: a prospective cohort study

Lancet Reg Health Am. 2026 Mar 13;56:101428. doi: 10.1016/j.lana.2026.101428. eCollection 2026 Apr.ABSTRACTBACKGROUND: As life expectancy increases, more adults aged ≥80 years are diagnosed with early-stage lung cancer. Often these patients are excluded from screening programs and clinical trials du

L Louis Gros