Actionable genotypes beyond the coding sequence and their association with lifespan in the UK Biobank

J Med Genet. 2026 Aug 12:jmg-2026-111659. doi: 10.1136/jmg-2026-111659. Online ahead of print.ABSTRACTBACKGROUND: The identification and reporting of actionable genotypes in the American College of Medical Genetics and Genomics (ACMG)-recommended secondary findings (SF) genes represent a key prevent

C Congcong Chen

Pathophysiological and clinical significance of hepatokine Fetuin-A and myocardial N-myristoylation in heart failure

Fukushima J Med Sci. 2026 Aug 13. doi: 10.5387/fms.26-00021. Online ahead of print.ABSTRACTHeart failure (HF) is a systemic syndrome in which myocardial remodeling and multiorgan dysfunction exacerbate each other. This review focuses on the hepatokine Fetuin-A and the post-translational modification

Y Yusuke Tomita

Endovascular thrombectomy alone versus intravenous thrombolysis plus endovascular thrombectomy on acute basilar artery occlusion (ATTENTION IV): study protocol for a multicentre randomised controlled trial

BMJ Open. 2026 Aug 12;16(8):e116898. doi: 10.1136/bmjopen-2026-116898.ABSTRACTINTRODUCTION: The DEVT and DIRECT-MT trials showed that endovascular thrombectomy (EVT) alone is non-inferior to intravenous thrombolysis (IVT) followed by EVT in achieving 90-day functional independence for stroke patient

R Rui Li

Does cathodal HD-tDCS-preconditioned iTBS over the contralesional dorsal premotor cortex improve upper limb motor function in patients with severe ischaemic stroke? A study protocol for a single-centre, participant-blinded and outcome assessor-blinded randomised controlled trial

BMJ Open. 2026 Aug 12;16(8):e120996. doi: 10.1136/bmjopen-2026-120996.ABSTRACTINTRODUCTION: The contralesional dorsal premotor cortex (cPMd) is a potential target for motor recovery in severe stroke. However, interindividual heterogeneity and the limited efficacy of standalone repetitive transcrania

S Sisi Zhu

Re: Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial

Clin Obes. 2026 Oct;16(5):e70094. doi: 10.1111/cob.70094.ABSTRACTThis correspondence addresses the EXERDIET-HTA substudy by Aparicio and colleagues, which concludes that 16 weeks of aerobic exercise plus a hypocaloric DASH diet reduced serum leptin more than diet with activity counselling in hyperte

M Maajid Mohi Ud Din Malik

Extensive spontaneous coronary artery dissection complicated by ventricular tachycardia storm and cardiogenic shock

BMJ Case Rep. 2026 Aug 12;19(8):e273433. doi: 10.1136/bcr-2026-273433.ABSTRACTA healthy man in his 40s presented with acute anterolateral ST-segment elevation myocardial infarction after sudden-onset chest pain during a coughing episode. Coronary angiography and intravascular ultrasound revealed ext

Y Yen Wing Ng

Electrical storm after percutaneous coronary intervention for subacute anterior myocardial infarction with heart failure, treated with multidisciplinary therapy

BMJ Case Rep. 2026 Aug 11;19(8):e271567. doi: 10.1136/bcr-2025-271567.ABSTRACTElectrical storm (ES) following acute coronary syndrome is rare but often fatal. A man in his early 70s experienced syncope and dyspnoea while playing golf, approximately 2 weeks after experiencing back pain. He was diagno

Y Yasuhito Nakata

Rare culprit and clinical dilemma: thrombolysis in a spontaneous anterior cerebral artery dissection

BMJ Case Rep. 2026 Aug 12;19(8):e270570. doi: 10.1136/bcr-2025-270570.ABSTRACTIntracranial arterial dissection (IAD) is a rare cause of ischaemic stroke, with involvement of the anterior cerebral artery (ACA) being uncommon. We present the case of a woman in her mid-40s who developed acute right leg

U Usman Saleem

Pseudo-heart failure in pregnancy complicated by preeclampsia: giant mediastinal teratoma with extrinsic cardiopulmonary compression

BMJ Case Rep. 2026 Aug 12;19(8):e274681. doi: 10.1136/bcr-2026-274681.ABSTRACTA woman in her early 20s at 30 weeks of gestation presented with elevated blood pressure, transaminitis, progressive dyspnoea, orthopnoea, exertional chest pain and peripheral oedema, raising concern for preeclampsia-assoc

J Jose Lopez Ventosa

Balamuthia mandrillaris presenting as central nervous system vasculitis in a young child

BMJ Case Rep. 2026 Aug 12;19(8):e275051. doi: 10.1136/bcr-2026-275051.ABSTRACTBalamuthia mandrillaris is a rare and difficult-to-diagnose infection with high mortality. We present the case of an immunocompetent toddler presenting with central nervous system (CNS) vasculitis. He was initially diagnos

E Emily Anne Carsello

Patient experience and stroke care quality: a quality improvement initiative in Northeastern Ontario

BMJ Open Qual. 2026 Aug 12;15(3):e003751. doi: 10.1136/bmjoq-2025-003751.ABSTRACTBACKGROUND: Patient-reported experience measures (PREM) are key indicators of healthcare quality linked to improved outcomes. The Canadian Stroke Best Practice Recommendations emphasise the importance of capturing patie

V Venkadesan Rajendran

Conduction system pacing vs. biventricular pacing for cardiac resynchronization therapy in heart failure: a systematic review and meta-analysis considering randomized controlled trials and observational studies

Europace. 2026 Aug 4;28(8):euag169. doi: 10.1093/europace/euag169.ABSTRACTAIMS: Biventricular pacing (BiVP) is the gold standard for cardiac resynchronization therapy (CRT) in heart failure with reduced ejection fraction (HFrEF), yet up to 30% of patients fail to respond. Conduction system pacing (C

K Karanjeet Chauhan

Conduction system vs. biventricular pacing in heart failure with reduced ejection fraction: a meta-analysis of randomized controlled trials

Europace. 2026 Aug 4;28(8):euag170. doi: 10.1093/europace/euag170.ABSTRACTAIMS: Conduction system pacing (CSP) has emerged as a physiologic alternative to cardiac resynchronization therapy (CRT) with biventricular pacing (BiVP) in heart failure with reduced ejection fraction (HFrEF), yet its compara

P Paschalis Karakasis

Differential Prognostic Impact of Potent P2Y₁₂ Inhibitors in Patients With Acute Myocardial Infarction by Bleeding Risk

Korean Circ J. 2026 Jul 7. doi: 10.4070/kcj.2026.0033. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVES: Limited data on the comparative efficacy and safety of potent P2Y₁₂ inhibitors versus clopidogrel in patients with acute myocardial infarction (AMI) stratified by bleeding risk. This study

H Hyun Sung Joh

Tailored Calibration Approach for Hemodynamic Boundary Conditions in CT-FFR

Korean Circ J. 2026 Jul 2. doi: 10.4070/kcj.2025.0535. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVES: Computed tomography-derived fractional flow reserve (CT-FFR) uses standardized boundary conditions that cannot represent individual patient characteristics. We developed a calibration meth

Y Yoon A Kim

Kidney outcomes and safety of sodium-glucose cotransporter-2 inhibitor therapy in autosomal dominant polycystic kidney disease: systematic review and meta-analysis

Diabetes Res Clin Pract. 2026 Aug 12:113496. doi: 10.1016/j.diabres.2026.113496. Online ahead of print.ABSTRACTBACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and among the leading causes of kidney failure globally. Sodium-glucose cotrans

M Mehmet Kanbay

Sex-dependent divergence between skeletal and cardiac responses to phosphate load in experimental CKD

Bone. 2026 Aug 12:118050. doi: 10.1016/j.bone.2026.118050. Online ahead of print.ABSTRACTChronic kidney disease (CKD) induces a progressive decline in kidney function, leading to increased inorganic phosphate (Pi) load resulting in higher fibroblast growth factor 23 (FGF23) and cardiovascular compli

L Lauriane Hivert

Pharmacogenomic and Drug Interactions Risk in Cardio-Oncology: A precision medicine perspective for India

Curr Probl Cardiol. 2026 Aug 12:103422. doi: 10.1016/j.cpcardiol.2026.103422. Online ahead of print.ABSTRACTCardio-oncology patients may face complex treatment regimens due to the concurrent existence of cancer and cardiovascular disease, leading to a considerable polypharmacy burden. This significa

A Aanya Verma

Myocardial remodeling and fibrosis by cardiovascular magnetic resonance in adults with congenital aortic valve stenosis

Int J Cardiol. 2026 Aug 12:134726. doi: 10.1016/j.ijcard.2026.134726. Online ahead of print.ABSTRACTBACKGROUND: Left ventricular (LV) remodeling is becoming increasingly important in assessing the impact of aortic stenosis (AS). However, data on structural LV remodeling in congenital AS patients is

Z Zoë A Keuning

Stereotactic Body Radiotherapy for Cardiac Arrhythmias: Current Evidence and Clinical Boundaries

Trends Cardiovasc Med. 2026 Aug 12:S1050-1738(26)00105-2. doi: 10.1016/j.tcm.2026.08.006. Online ahead of print.ABSTRACTStereotactic arrhythmia radioablation (STAR), also known as cardiac stereotactic body radiotherapy, is an emerging noninvasive strategy for arrhythmia substrate modification. It tr

H Hansheng Li

Surgical Management of Carotid Body Tumors at a High-Altitude Center: A 22-Year Single-Institution Experience

Ann Vasc Surg. 2026 Aug 12:S0890-5096(26)00578-9. doi: 10.1016/j.avsg.2026.07.062. Online ahead of print.ABSTRACTOBJECTIVES: To evaluate surgical management and outcomes of carotid body tumors (CBTs) by Shamblin classification over 22 years at a center 1,853 m above sea level.METHODS: Among 107 pati

I Izatullah Jalalzai

Reflections on the Role of Cytomegalovirus in Postliver Transplantation Coronary Artery Disease

No abstractInt J Infect Dis. 2026 Aug 12:109041. doi: 10.1016/j.ijid.2026.109041. Online ahead of print.NO ABSTRACTPMID:42586364 | DOI:10.1016/j.ijid.2026.109041

Z Zhenxing Wang

Coronary stenosis or acute occlusion? Endpoint choice in AI-based coronary triage after cardiac arrest

No abstractResuscitation. 2026 Aug 12:111258. doi: 10.1016/j.resuscitation.2026.111258. Online ahead of print.NO ABSTRACTPMID:42586304 | DOI:10.1016/j.resuscitation.2026.111258

C Claudio Silwanis

A PIWI-interacting RNA-loaded Gelatin Methacryloyl Microneedle Patch Improves Wound Repair following Cutaneous Injury

Eur J Pharmacol. 2026 Aug 12:179235. doi: 10.1016/j.ejphar.2026.179235. Online ahead of print.ABSTRACTInducing cutaneous regeneration is a key strategy for significantly accelerating wound closure. A cardiac-regeneration-associated PIWI-interacting RNA (CRAPIR) has shown advantages in cardiomyocytes

Y Yang Yu