Echocardiography in Athletes: the Ever-Evolving Assessment of Physiology Versus Pathology

Curr Cardiol Rep. 2026 Jan 17;28(1):12. doi: 10.1007/s11886-025-02327-3.ABSTRACTPURPOSE OF REVIEW: This review article summarizes the established physiologic adaptations seen on echocardiogram in athletes and provides a focus update and perspective on changing diagnostic criteria in several patholog

J John T Fritzlen

Determinants of circulating PCSK9 levels and the efficacy of PCSK9 inhibitor therapies in chronic kidney disease: a systematic review

Eur J Clin Pharmacol. 2026 Jan 17;82(2):37. doi: 10.1007/s00228-025-03965-w.ABSTRACTPURPOSE OF REVIEW: Chronic kidney disease (CKD) significantly increases the risk of atherosclerotic cardiovascular disease (ASCVD), with dyslipidemia-particularly elevated low-density lipoprotein cholesterol (LDL-C)-

T Tatjana Ábel

IGF2BP3 in Multi-System Diseases: Molecular Mechanisms, Pathological Roles and Translational Insights

No abstractCell Biochem Biophys. 2026 Jan 17. doi: 10.1007/s12013-026-01991-8. Online ahead of print.NO ABSTRACTPMID:41546815 | DOI:10.1007/s12013-026-01991-8

Y Yue Ma

Machine Learning-Based Identification of Exosome-Associated Diagnostic Biomarkers in Acute Myocardial Infarction and in Silico Drug Prioritization

Cardiovasc Drugs Ther. 2026 Jan 17. doi: 10.1007/s10557-026-07835-0. Online ahead of print.ABSTRACTBACKGROUND: Acute myocardial infarction (AMI) is a major global health burden, with current diagnostic biomarkers often limited by delayed elevation and low specificity. Exosomes have emerged as promis

H Hairong Tang

Modulating CGRP Signaling: A Promising Therapeutic Avenue for Attenuating Cardiac Dysfunction in Heart Failure

Cardiovasc Drugs Ther. 2026 Jan 17. doi: 10.1007/s10557-025-07830-x. Online ahead of print.ABSTRACTHeart failure (HF) is a progressive clinical syndrome characterized by structural and functional cardiac impairment, leading to reduced cardiac output, hemodynamic instability, and high morbidity and m

S Shazia Ansari

MiR-874-3p suppresses TNF-α-induced inflammation in adipocytes by targeting nucleolin

J Mol Histol. 2026 Jan 17;57(1):49. doi: 10.1007/s10735-025-10703-0.ABSTRACTMany investigations have indicated the significance of microRNAs (miRNAs) as potential biomarkers for early obesity in children. MiR-874-3p was revealed to be downregulated in overweight/obese children. However, the specific

X Xingxiang Xu

Associations of growth trajectories from birth to two years of age with adolescent blood pressure: the mediating role of current BMI in the follow-up of an antenatal micronutrient supplementation trial

Eur J Pediatr. 2026 Jan 17;185(2):87. doi: 10.1007/s00431-026-06752-6.ABSTRACTWhile early-life growth patterns are thought to be pivotal for long-term cardiovascular health, their specific links to adolescent blood pressure (BP) and potential mediators remain unclear. We aimed to examine the associa

J Jiaxin Tian

Rationale and design of MUSIC-HFpEF: a phase 1b, pilot trial evaluating the safety and pharmacodynamic effects of AAV1.SERCA2A in heart failure with preserved ejection fraction

Heart Fail Rev. 2026 Jan 17;31(1):19. doi: 10.1007/s10741-025-10589-w.ABSTRACTHeart failure with preserved ejection fraction (HFpEF) has limited therapeutic options. Abnormal calcium handling through impaired sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) activity contributes to diastol

M Marat Fudim

Alteplase versus tenecteplase in acute ischemic stroke with large vessel occlusion: a systematic review and meta-analysis

Eur J Clin Pharmacol. 2026 Jan 17;82(2):39. doi: 10.1007/s00228-025-03967-8.ABSTRACTBACKGROUND: Intravenous thrombolysis remains a cornerstone in acute ischemic stroke (AIS) management, particularly in large vessel occlusion (LVO). While alteplase has long been the standard thrombolytic agent, tenec

M Mostafa Hossam El Din Moawad

Safety and efficacy of DOACs for non-cirrhotic splanchnic vein thrombosis: a single centre retrospective analysis

Eur J Clin Pharmacol. 2026 Jan 17;82(2):38. doi: 10.1007/s00228-025-03966-9.ABSTRACTBACKGROUND: In recent years, increasing evidence has emerged regarding the use of direct oral anticoagulants (DOACs) for the treatment of splanchnic vein thrombosis (SVT) in non-cirrhotic patients. However, available

L Luca Depietri

Efficacy and safety of esketamine for sedation during colonoscopy: A systematic review and Meta-analysis of randomized controlled trials

Eur J Clin Pharmacol. 2026 Jan 17;82(2):28. doi: 10.1007/s00228-025-03935-2.ABSTRACTBACKGROUND: Hemodynamic instability during colonoscopy sedation remains a significant clinical concern. Esketamine's sympathomimetic properties may protect against these risks while reducing sedative requirements. He

Z Zainab Hussein

Surgical Management of Ventricular Tachycardia Originating From Left Ventricular Diverticulum

JACC Case Rep. 2026 Jan 17:106800. doi: 10.1016/j.jaccas.2025.106800. Online ahead of print.ABSTRACTBACKGROUND: Congenital left ventricular diverticulum (LVD) is a rare cardiac malformation that may cause catastrophic complications, such as ventricular tachycardia (VT). The surgical indication for L

Z Zhiang Zhou

Pulmonary Vein-Triggered Atrial Fibrillation in Unrepaired Double-Outlet Right Ventricle With Pulmonary Atresia

JACC Case Rep. 2026 Jan 17:106738. doi: 10.1016/j.jaccas.2025.106738. Online ahead of print.ABSTRACTBACKGROUND: Direct electrophysiological evidence that the pulmonary vein (PV) triggers atrial fibrillation (AF) in patients with complex adult congenital heart disease (ACHD) is lacking; nevertheless,

T Takahiko Kinjo

Ventricular-arterial coupling in community-dwelling individuals and athletes with cervical spinal cord injury

J Appl Physiol (1985). 2026 Jan 17. doi: 10.1152/japplphysiol.00362.2025. Online ahead of print.ABSTRACTBackground: Cervical spinal cord injury (SCI) removes descending sympathetic control over the heart and vasculature which alters cardiovascular function. Ventricular-arterial coupling (VAC) provid

G Guillermo A Alanis

Effects of Exercise Duration and Intensity on Maximal Exercise Capacity Over 6 Months in Coronary Heart Disease and Type 2 Diabetes-A Secondary Analysis of the LeIKDTrial

Scand J Med Sci Sports. 2026 Jan;36(1):e70209. doi: 10.1111/sms.70209.ABSTRACTExercise training is recommended in coronary heart disease (CHD) and type 2 diabetes (T2DM) patients alike; however, uncertainty remains on the influence of exercise intensity and duration in older patients with both entit

F Felix Gass

Mechanisms underlying the therapeutic effects of Dendrobium officinale in treating metabolic syndrome based on clinical datasets, network pharmacology, molecular docking and enzyme kinetic assay

Pak J Pharm Sci. 2026 Feb;39(2):537-547. doi: 10.36721/PJPS.2026.39.2.REG.13184.1.ABSTRACTBACKGROUND: Metabolic syndrome (MetS) significantly increases risks for diabetes and cardiovascular diseases. Dendrobium officinale, a Traditional Chinese Medicine (TCM), shows potential in treating MetS, yet i

J Jianmei Wang

Lauric acid mitigates doxorubicin-induced cardiotoxicity in rats: Modulation of oxidative stress and inflammation via NF-κB p65 attenuation

Pak J Pharm Sci. 2026 Feb;39(2):487-502. doi: 10.36721/PJPS.2026.39.2.REG.14740.1.ABSTRACTBACKGROUND: Cardiotoxic effects of doxorubicin (DOX) have been reported in cancer patients, which mainly stem from the production of reactive oxygen species (ROS). This oxidative damage contributes to myocardia

S Samreen Aziz

Protective effects of Cynanchum auriculatum Royle ex Wight on testicular reproductive decline in naturally aging male rats

Pak J Pharm Sci. 2026 Feb;39(2):449-455. doi: 10.36721/PJPS.2026.39.2.REG.14844.1.ABSTRACTBACKGROUND: The aging process leads to organ degeneration, including testicular aging, which not only impairs fertility but also increases the risk of reproductive system diseases, significantly reducing the qu

X Xuan Shen

Efficacy of combined atorvastatin and argatroban therapy in acute cerebral infarction

Pak J Pharm Sci. 2026 Feb;39(2):398-405. doi: 10.36721/PJPS.2026.39.2.REG.15155.1.ABSTRACTBACKGROUND: Acute cerebral infarction (ACI) is a disease which seriously affects the people's health.OBJECTIVES: To investigate the efficacy of combined atorvastatin and argatroban therapy in patients with ACI

W Weihua Xu

Examination of effect of jervine purified from the Veratrum album on changes in testicular tissue of varicocele-induced rats

Pak J Pharm Sci. 2026 Feb;39(2):353-361. doi: 10.36721/PJPS.2026.39.2.REG.13431.1.ABSTRACTBACKGROUND: Varicocele is a dilatation of the pampiniform plexus. It is generally considered the most common cause of male infertility.OBJECTIVES: This study aimed to investigate the effects of jervine on testi

S Serdar Yigit

Pharmacist-led antiarrhythmic counseling clinic for supraventricular tachycardia in congenital heart disease patients

Pak J Pharm Sci. 2026 Feb;39(2):326-331. doi: 10.36721/PJPS.2026.39.2.REG.15244.1.ABSTRACTBACKGROUND: Pharmacist provision in pediatric arrhythmia service is limited in low- to middle-income countries, despite this chronic condition demands adherence to prescribed regimens for better therapeutic out

A Aniqa Batool

Comparative analysis of three different serum-free light chain assays in the diagnosis of multiple myeloma

Ann Med. 2026 Dec;58(1):2615487. doi: 10.1080/07853890.2026.2615487. Epub 2026 Jan 17.ABSTRACTBACKGROUND: The lack of analysis methods and standardization are the core problems of serum free light chain (sFLC) detection in Multiple myeloma (MM). This study validated a new KHB sFLC assay through comp

F Facai Cui

Prediction model for cardiovascular mortality risk in asthma patients based on machine learning

J Asthma. 2026 Jan 17:1-17. doi: 10.1080/02770903.2026.2618108. Online ahead of print.ABSTRACTBackgroundAsthma is a common chronic respiratory disease, cardiovascular disease (CVD) mortality constitutes a major public health concern. At present, no personalized tools are available to accurately esti

Y Yuxi Wang

WW Domain-Binding Protein 2 Aggravates Neointimal Hyperplasia by Promoting Y-Box Binding Protein 1 Nuclear Translocation

FASEB J. 2026 Jan 31;40(2):e71470. doi: 10.1096/fj.202504063R.ABSTRACTCardiovascular interventional therapy continues to face a major challenge in clinical practice due to the presence of restenosis after PCI. Continuous exploration uncovers novel signaling molecules implicated in this pathophysiolo

L Lili Xiao