PARPs and PARP inhibitors: molecular mechanisms and clinical applications

Mol Biomed. 2025 Dec 29;6(1):152. doi: 10.1186/s43556-025-00385-1.ABSTRACTPoly (ADP-ribose) polymerases (PARPs) are a diverse family of enzymes that regulate genome stability, cell death, and stress responses through ADP-ribosylation. Among them, PARP1, PARP2, and PARP3 are central to cellular DNA r

F Fei Wang

Pros and cons of lower blood pressure targets in chronic kidney disease

Curr Opin Nephrol Hypertens. 2025 Dec 30. doi: 10.1097/MNH.0000000000001153. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Optimal blood pressure control is essential for managing chronic kidney disease (CKD), as it can reduce cardiovascular risk and mortality. However, recent updates in major in

M Mario Funes Hernandez

Evolution in the targets for blood pressure treatment

Curr Opin Nephrol Hypertens. 2025 Dec 30. doi: 10.1097/MNH.0000000000001152. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review focuses on new nonpharmacological and drug therapies for lowering blood pressure, hypertension treatment goals, and strategies to improve hypertension control.REC

P Paul K Whelton