ProtFI, an efficient frailty-trained proteomics-based biomarker of aging, robustly predicts age-related decline

Cell Rep Methods. 2026 Apr 10:101405. doi: 10.1016/j.crmeth.2026.101405. Online ahead of print.ABSTRACTMany molecular aging biomarkers have been developed to capture heterogeneity in individual aging rates. Yet, systematic comparison of the modeling choices underlying these biomarkers has been limit

S Swier Garst

Development of a multifunctional fluorescent probe for smartphone-assisted detection of formaldehyde in food in 100% aqueous solution and diabetic models

Spectrochim Acta A Mol Biomol Spectrosc. 2026 Apr 10;358:127876. doi: 10.1016/j.saa.2026.127876. Online ahead of print.ABSTRACTFormaldehyde (FA), a biological metabolic intermediate, poses severe health risks, including carcinogenicity, cardiovascular disease, and neurological disorders, upon excess

H Huawei Niu

"EPAC1: Molecular Architecture, Physiological Regulation, and Therapeutic Implications in Diseases"

Int J Biochem Cell Biol. 2026 Apr 9:106944. doi: 10.1016/j.biocel.2026.106944. Online ahead of print.ABSTRACTExchange Protein Directly Activated by cAMP 1 (EPAC1) is an intracellular effector of the small GTPases Rap1 and Rap2, functioning independently of protein kinase A in the cAMP signalling pat

A Adiba Mussarrat

Investigating prognostic classifications of pre-existing multiple long-term conditions for health outcomes one-year after COVID-19 hospitalisation: a UK prospective observational study

Int J Infect Dis. 2026 Apr 9:108695. doi: 10.1016/j.ijid.2026.108695. Online ahead of print.ABSTRACTBACKGROUND: Pre-existing multiple (two or more) long-term conditions (MLTCs) may negatively affect recovery after COVID-19. We investigated how pre-existing MLTCs, including different categorisation a

L Lucy E Gardiner

Self-enhancement-based perfusion mapping with contrast-enhanced magnetic resonance imaging for PAD assessment

Magn Reson Imaging. 2026 Apr 9:110678. doi: 10.1016/j.mri.2026.110678. Online ahead of print.ABSTRACTWe developed an automatic self-enhancement-based perfusion mapping (SEPM) method to relatively map the microvascular perfusion level in contrast-enhanced magnetic resonance imaging (CE-MRI) into four

B Bijen Khagi

Estimating the preventable burden of cardiovascular disease attributable to ultra-processed dietary patterns in Canada: A modeling study

Am J Prev Med. 2026 Apr 9:108363. doi: 10.1016/j.amepre.2026.108363. Online ahead of print.ABSTRACTINTRODUCTION: The consumption of ultra-processed foods (UPF) has been associated with increased risks of chronic diseases, particularly cardiovascular diseases (CVD). However, specific data on the CVD

H Hamel V

Blood Pressure Trends among Autistic Youth Transitioning to Adult Care: A Retrospective Cohort Study

Am J Prev Med. 2026 Apr 9:108372. doi: 10.1016/j.amepre.2026.108372. Online ahead of print.ABSTRACTINTRODUCTION: Autistic people have higher rates of cardiovascular disease and its risk factors than non-autistic peers. Transition from pediatric to adult health care is associated with health challeng

L Laura C Hart

Optimizing Identification of Major Adverse Limb and Cardiovascular Events Among Adults with Peripheral Artery Disease in Administrative Data

J Vasc Surg. 2026 Apr 9:S0741-5214(26)00842-6. doi: 10.1016/j.jvs.2026.03.614. Online ahead of print.ABSTRACTOBJECTIVE: Atherosclerotic cardiovascular diseases (ASCVD) are the commonest cause of death. Peripheral artery disease (PAD) is an ASCVD that significantly increases risk of death and reduces

H Hasan Nassereldine

Desynchronise, Disconnect, Reorganise, Collapse (DDRC): A Theoretical Framework Linking White Matter Pathology and Cognitive Dysfunction in Vascular Disease

Neurosci Biobehav Rev. 2026 Apr 9:106687. doi: 10.1016/j.neubiorev.2026.106687. Online ahead of print.ABSTRACTWhite matter health is closely associated with cognitive function, particularly across the spectrum of cerebrovascular health. However, inconsistencies in the cognitive domains reported to b

K Katie L Moran

Beyond the STEMI Paradigm: Expanding the Scope of microAxial Flow Pump in Cardiogenic Shock

J Heart Lung Transplant. 2026 Apr 9:S1053-2498(26)01826-7. doi: 10.1016/j.healun.2026.03.036. Online ahead of print.ABSTRACTBACKGROUND: Microaxial flow pumps (mAFP) are increasingly used to treat cardiogenic shock (CS), but most evidence comes from acute myocardial infarction-related CS (AMI-CS). It

A Aurore Ughetto

Age at type 2 diabetes diagnosis, mortality, and health loss in South Asians

Diabetes Res Clin Pract. 2026 Apr 9:113259. doi: 10.1016/j.diabres.2026.113259. Online ahead of print.ABSTRACTOBJECTIVE: We examined associations between age at type 2 diabetes (T2D) diagnosis and long-term mortalityand lifetime health loss.RESEARCH DESIGN AND METHODS: We analyzed data from the popu

R Ram Jagannathan

The combined estimated glucose disposal rate and frailty index predicts cardiovascular events and mortality: A prospective cohort study from CHARLS

Diabetes Res Clin Pract. 2026 Apr 9:113258. doi: 10.1016/j.diabres.2026.113258. Online ahead of print.ABSTRACTBACKGROUND: Estimated glucose disposal rate (eGDR) and frailty index (FI) captures insulin resistance and multisystem decline, respectively. However, the combined prognostic value of eGDR an

L Linfeng Xie

Comparative Analysis of Clinical Features and Autoantibody Profiles in Systemic Sclerosis Patients Among Jewish and Arab Populations in Israel

Isr Med Assoc J. 2026 Apr;28(4):237-242.ABSTRACTBACKGROUND: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of the skin and internal organs. Its expression can vary across ethnic groups.OBJECTIVES: To compare clinical and serological manifestations of SSc between J

H Hitam Hagog Natour

Clinical spectrum and outcomes of pericardial and myocardial disease in systemic sclerosis: a multicentre case series and literature review

ARP Rheumatol. 2026 Jan-Mar;5(1):15-26.ABSTRACTOBJECTIVES: Cardiac involvement is a leading cause of morbidity and mortality in systemic sclerosis (SSc) yet is often underdiagnosed. Early recognition is crucial but published data remains limited. This study aimed to characterize the clinical present

C Cristiana Sieiro Santos

Comparative analysis of inflammatory and metabolic indices (HALP score, NLR, LMR, and TyG index) in healthy individuals, dipper, and non-dipper hypertensive phenotypes

Clin Exp Hypertens. 2026 Dec 31;48(1):2657358. doi: 10.1080/10641963.2026.2657358. Epub 2026 Apr 12.ABSTRACTOBJECTIVE: This study aimed to compare the metabolic and inflammatory profiles of dipper and non-dipper hypertensive patients versus healthy controls, specifically evaluating the Triglyceride-

H Huseyin Kandemir

Geriatric Pharmacotherapy Case Series: GLP-1 RA for Weight Management in Older Adults

Sr Care Pharm. 2026 Apr 1;41(3):78-87. doi: 10.4140/TCP.n.2026.78.ABSTRACTBackground: This case study reviews the use of glucagon-like peptide-1 receptor agonists (GLP-1 RA) for weight management in older adults. A 69-year-old male patient discusses weight loss goals with his health care provider an

L Lauren Toma

A polysaccharide from Pueraria lobata ameliorates hepatic fibrosis via gut microbiota-dependent suppression of ferroptosis

Phytomedicine. 2026 Mar 27;155:158123. doi: 10.1016/j.phymed.2026.158123. Online ahead of print.ABSTRACTBACKGROUND: Hepatic fibrosis, driven by oxidative stress and subsequent hepatocellular injury, represents a major worldwide health challenge. Pueraria lobata Radix, a traditional Chinese herb, con

J Jiangping Wu

Senkyunolide I attenuates radiation-induced cognitive dysfunction by restoring PINK1-Parkin-mediated mitophagy and redox homeostasis

Phytomedicine. 2026 Mar 31;155:158136. doi: 10.1016/j.phymed.2026.158136. Online ahead of print.ABSTRACTBACKGROUND: Radiation-induced cognitive dysfunction (RICD) is a prevalent and long-term complication of cranial radiotherapy, characterized by hippocampal-dependent learning and memory impairment

T Tao Yan

Socioeconomic position and type 2 diabetes: The mediating role of physical work environment - the Maastricht study

Soc Sci Med. 2026 Mar 25;400:119240. doi: 10.1016/j.socscimed.2026.119240. Online ahead of print.ABSTRACTLow socioeconomic position (SEP) is a risk factor for type 2 diabetes (T2D) creating socioeconomic health disparities. These inequalities might arise from differences in environmental conditions

B Bengisu Sezer

Therapeutic potential of ADAR1-regulated macrophage exosomes for improving myocardial damage in septic cardiomyopathy

J Nanobiotechnology. 2026 Apr 11. doi: 10.1186/s12951-026-04368-4. Online ahead of print.ABSTRACTBACKGROUND: Sepsis-induced cardiomyopathy (SICM) is a critical cardiovascular complication characterized by cardiac dysfunction and high mortality. The molecular mechanisms that underlie SICM remain elus

L Linxiao Wang

Effectiveness of a multi-component intervention strategy on blood pressure control among older patients with hypertension: a target trial emulation

No abstractBMC Geriatr. 2026 Apr 11. doi: 10.1186/s12877-026-07452-4. Online ahead of print.NO ABSTRACTPMID:41965538 | DOI:10.1186/s12877-026-07452-4

B Bing Pei

Practical Recommendations for Cardiology Follow-Up in Patients Treated with Fenfluramine Based on Expert Opinion and Clinical Experience

Neurol Ther. 2026 Apr 11. doi: 10.1007/s40120-026-00930-2. Online ahead of print.ABSTRACTINTRODUCTION: Fenfluramine (FFA) is approved as an adjunctive treatment for epileptic seizures associated with Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS) in patients aged 2 years and older. Owing to

A Antonio Gil-Nagel

A time-series analysis of the short-term effects of daily PM2.5 exposure on cause-specific mortality in Mashhad, Iran (2019-2024)

Fine particulate matter (PM(2.5)) is a major environmental risk factor associated with increased mortality from cardiovascular and respiratory diseases worldwide. This study examined the short-term association between daily PM(2.5) exposure and cause-specific mortality in Mashhad, a large metropolit

M Majid Kermani

Acteoside attenuates myocardial ischemia reperfusion injury by inhibiting the NLRP3 inflammasome activity via the PI3K/Akt signaling pathway

No abstractSci Rep. 2026 Apr 11. doi: 10.1038/s41598-026-47002-x. Online ahead of print.NO ABSTRACTPMID:41965388 | DOI:10.1038/s41598-026-47002-x

L Linlin Jia