Effects of Vericiguat on the Mitochondrial Function and Clinical Outcomes in CRT Nonresponders Patients

JACC Adv. 2026 Apr 4;5(5):102708. doi: 10.1016/j.jacadv.2026.102708. Online ahead of print.ABSTRACTBACKGROUND: Cardiac resynchronization therapy (CRT) failure leads to adverse remodeling and poor outcomes.OBJECTIVES: The purpose of this study was to evaluate vericiguat effects on outcomes, mitochond

C Celestino Sardu

Atractylodin ameliorates obesity-associated hepatic steatosis by regulating the PLIN2-ATGL/CPT1A axis-mediated lipid droplet-mitochondria interactions

Phytomedicine. 2026 Mar 28;155:158134. doi: 10.1016/j.phymed.2026.158134. Online ahead of print.ABSTRACTBACKGROUND: Obesity prevalence is rising, increasing risks of ‌metabolic associated fatty liver disease, diabetes mellitus, and cardiovascular disease. Atractylodin (ATR), a bioactive compound fro

J Jian Chen

DMARDs and gout therapy in patients with chronic arthritis and end-stage renal disease: a descriptive guide

Acta Clin Belg. 2026 Apr 5:1-14. doi: 10.1080/17843286.2026.2654069. Online ahead of print.ABSTRACTOBJECTIVES: The coexistence of chronic arthritis - here defined as rheumatoid arthritis, spondyloarthritis and gout - and end-stage renal disease (ESRD) is clinically relevant, underscoring the need fo

H Hebe Stuer

Association of Serum ADMA with Endothelial Dysfunction in Chronic Periodontitis and Coronary Heart Disease Patients

Curr Hypertens Rev. 2026 Mar 18. doi: 10.2174/0115734021434691260120091010. Online ahead of print.ABSTRACTINTRODUCTION: Asymmetric Dimethylarginine (ADMA), a natural NO production inhibitor, is a key indicator of endothelial dysfunction. ADMA damages vessels and endothelial function by inhibiting NO

A Afsheen Zehra

Primary myocardial involvement in systemic sclerosis: pathophysiology, clinical manifestations, and advances in cardiac imaging

Rheumatology (Oxford). 2026 Apr 4:keag167. doi: 10.1093/rheumatology/keag167. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is a rare systemic autoimmune rheumatic disease associated with the highest cardiovascular risk among autoimmune conditions. Beyond pulmonary complications, primary he

M Maya H Buch

The Emerging Role of tRNA-Derived Small RNAs (tsRNAs) in Radiation-Induced Cardiovascular Pathology

Endocr Metab Immune Disord Drug Targets. 2026 Mar 30. doi: 10.2174/0118715303460374260127095032. Online ahead of print.ABSTRACTINTRODUCTION: Ionizing radiation exposure during thoracic radiotherapy is a risk factor for long-term cardiovascular morbidity, including radiation-induced heart disease (RI

Y Ying Chen

Methotrexate-Induced Encephalopathy Mimicking Acute Ischemic Stroke in an Adolescent With Osteosarcoma: A Case Report

Am J Case Rep. 2026 Apr 5;27:e951751. doi: 10.12659/AJCR.951751.ABSTRACTBACKGROUND Methotrexate-induced encephalopathy is an uncommon but potentially serious neurotoxic complication of high-dose methotrexate therapy. Its clinical and radiological features can closely resemble acute ischemic stroke,

T Trinh Van Duong

LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing

Mol Ther. 2026 Apr 3:S1525-0016(26)00265-0. doi: 10.1016/j.ymthe.2026.03.038. Online ahead of print.ABSTRACTAngiogenesis is a key function of vascular endothelial cells, and becomes aberrant in pathologies like preeclampsia. An important mediator of angiogenesis is vascular endothelial growth factor

F Frederike Lam

Association of cardiovascular-kidney-metabolic syndrome with cardiovascular, cancer, and all-cause mortality among US adults: A prospective study

J Formos Med Assoc. 2026 Apr 3:S0929-6646(26)00331-1. doi: 10.1016/j.jfma.2026.03.148. Online ahead of print.ABSTRACTAIMS: Cardiovascular-kidney-metabolic (CKM) syndrome, comprising chronic kidney disease, cardiovascular disease (CVD), and metabolic syndrome, poses a significant threat to global pub

C Cheng Zhang

Guideline-based lipid-lowering therapy in acute coronary syndromes: A simulation of population-level impact on cardiovascular events and LDL-C goal achievement

J Clin Lipidol. 2026 Mar 14:S1933-2874(26)00074-7. doi: 10.1016/j.jacl.2026.03.007. Online ahead of print.ABSTRACTBACKGROUND: Despite high cardiovascular risk, many patients with acute coronary syndrome (ACS) do not receive timely intensification of lipid-lowering therapy (LLT).OBJECTIVE: To predict

D Dylan L Steen

Association of LDL-C between parents and younger offspring: A cross-sectional study using the Korea National Health and Nutrition Examination Survey

J Clin Lipidol. 2026 Mar 15:S1933-2874(26)00073-5. doi: 10.1016/j.jacl.2026.03.009. Online ahead of print.ABSTRACTBACKGROUND: Atherosclerotic cardiovascular disease develops in adulthood, but its metabolic precursors, such as dyslipidemia, often emerge during childhood.OBJECTIVE: This study aimed to

H Hee Yeon Kay

The effect of sodium-glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors on the lipid profiles of patients with type II diabetes and coronary artery disease: A retrospective study

J Clin Lipidol. 2026 Mar 16:S1933-2874(26)00070-X. doi: 10.1016/j.jacl.2026.03.010. Online ahead of print.ABSTRACTBACKGROUND: Patients with type 2 diabetes mellitus and established coronary artery disease (CAD) carry a very high cardiovascular risk, requiring aggressive lipid management. Sodium-gluc

A Anish Theertham

Global burden of aortic aneurysm attributed to high systolic blood pressure from 1990 to 2021: a systematic analysis of the global burden of disease study

Nutr Metab Cardiovasc Dis. 2026 Feb 26:104642. doi: 10.1016/j.numecd.2026.104642. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Aortic aneurysm (AA) is a significant cardiovascular condition with high mortality and disability burdens. High systolic blood pressure (SBP) is a major modifiable ris

H Hao Liu

Subclinical carotid atherosclerosis in latent autoimmune diabetes in adults and type 2 diabetes mellitus: a cross-sectional study

Nutr Metab Cardiovasc Dis. 2026 Mar 4:104675. doi: 10.1016/j.numecd.2026.104675. Online ahead of print.ABSTRACTBACKGROUND AND AIM: Despite differing clinical phenotypes, the cardiovascular-metabolic risks and complications of latent autoimmune diabetes in adults (LADA) versus type 2 diabetes mellitu

T Tiantian Cai

Serum uric acid as a reflection of residual risk in statin-treated patients with cardiovascular disease: Insights from NHANES 1999-2018

Nutr Metab Cardiovasc Dis. 2026 Feb 11:104603. doi: 10.1016/j.numecd.2026.104603. Online ahead of print.ABSTRACTBACKGROUND AND AIM: Serum uric acid (SUA) is associated with cardiovascular disease (CVD) prognosis, and statins may modulate SUA levels. The purpose of this study is to investigate the pr

Z Zhe Zhang

Metabolite clusters linking fatty liver disease to cardiovascular mortality in coronary heart disease patients

Nutr Metab Cardiovasc Dis. 2025 Dec 24:104535. doi: 10.1016/j.numecd.2025.104535. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: We aimed to identify metabolite clusters and assess their relationships with prevalent steatotic liver disease (SLD) and fatal cardiovascular diseases (CVD) risk in co

L Luc Heerkens

Dietary antioxidants and cardiometabolic health in the Ardabil Persian cohort

Nutr Metab Cardiovasc Dis. 2026 Mar 2:104665. doi: 10.1016/j.numecd.2026.104665. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Cardiovascular diseases (CVDs) remain a major global health burden, with oxidative stress and inflammation playing key roles in their development. This study investigat

M Mahsa Mohajeri

Trends and Disparities in Aortic Stenosis and Coronary Artery Disease-Related Mortality Among U.S. Adults Aged 65 Years, 1999-2024

Ann Vasc Surg. 2026 Apr 2:S0890-5096(26)00221-9. doi: 10.1016/j.avsg.2026.03.051. Online ahead of print.ABSTRACTINTRODUCTION: Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist in older adults due to shared risk factors and overlapping pathophysiologic mechanisms. Despite subs

S Shaikh Muhammad Daniyal

Key Role of the Pharmacist in Collaboration with General Practitioners and Nephrologists in the Management of Chronic Kidney Disease

Ann Pharm Fr. 2026 Apr 2:S0003-4509(26)00042-8. doi: 10.1016/j.pharma.2026.03.004. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is a major public health issue, affecting nearly 10% of the adult population, with a significant proportion of diagnoses occurring at advanced stages, often r

S Sophie Liabeuf

Impella Protected Percutaneous Coronary Intervention Outcomes Compared with Intra-Aortic Balloon Pump: A Contemporary View

Am J Cardiol. 2026 Apr 2:S0002-9149(26)00203-1. doi: 10.1016/j.amjcard.2026.03.060. Online ahead of print.ABSTRACTTraditional cardiovascular trials combine adverse events into composites, ignoring the clinical importance and weight of endpoints. The Win Ratio ("WR") is a contemporary statistical tec

V Vasileios Panoulas

Risk factors for Klebsiella spp. infection after solid organ transplantation: a multi-center, case-control study

J Hosp Infect. 2026 Apr 2:S0195-6701(26)00120-9. doi: 10.1016/j.jhin.2026.03.030. Online ahead of print.ABSTRACTBACKGROUND: Klebsiella spp. are a major cause of antimicrobial-resistant hospital-acquired infections. We aimed to identify possible risk factors for Klebsiella infection during 180 days a

A Argyro Ftergioti

Nonlinear and Episodic Growth in the Natural History of Ascending Aortic Dilation

Can J Cardiol. 2026 Apr 2:S0828-282X(26)00284-9. doi: 10.1016/j.cjca.2026.03.035. Online ahead of print.ABSTRACTBACKGROUND: Predicting ascending aortic (AsAo) growth is challenging. Linear, continuous assumptions may oversimplify biology. We evaluated: (1) whether baseline body size-indexed diameter

C Carlos Alberto Campello Jorge

Genetic variation at the MECOM locus shaping human disease pathogenesis

Pharmacol Ther. 2026 Apr 2:109027. doi: 10.1016/j.pharmthera.2026.109027. Online ahead of print.ABSTRACTThe gene MDS1 and EVI1 complex locus (MECOM) functions as a transcriptional regulator essential for development. Variants in MECOM have been recognized as pathogenic drivers, with well-established

J Jiayi Chen

Implanted Electronic Device Management in a Pencil-Beam Scanning Proton-Therapy Clinic

Pract Radiat Oncol. 2026 Apr 2:S1879-8500(26)00102-5. doi: 10.1016/j.prro.2026.03.004. Online ahead of print.ABSTRACTPURPOSE: Present single-institution workflows and experience for treating patients with implanted electronic devices (IEDs) at a high-volume proton pencil-beam scanning clinic.METHODS

M Mark D Pepin