Metabolic reprogramming drives pancreatic β cell neogenesis from α cells

Nat Chem Biol. 2026 Aug 7. doi: 10.1038/s41589-026-02293-z. Online ahead of print.ABSTRACTLoss of functional β cells is a hallmark of diabetes, and restoring β cell mass remains a critical goal in the quest for a specific therapy. One potential strategy is to convert non-β cells in the islet, such a

Y Yufeng Zhang

STOP-RIO study: protocol for a randomised, controlled, open-label non-inferiority trial to test the safety of discontinuation of riociguat after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension

BMJ Open. 2026 Aug 7;16(8):e120820. doi: 10.1136/bmjopen-2026-120820.ABSTRACTINTRODUCTION: Balloon pulmonary angioplasty (BPA) improves haemodynamics and outcomes in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Riociguat is frequently initiated before BPA to reduce

T Tamara Carina Rodenburg

Central Sleep Apnea in Cardiovascular Diseases

Sleep Med Clin. 2026 Sep;21(3):317-331. doi: 10.1016/j.jsmc.2026.06.005. Epub 2026 Jul 14.ABSTRACTThis article provides an overview of central sleep apnea (CSA) in the context of cardiovascular diseases (CVDs), highlighting its common association with conditions such as heart failure, atrial fibrill

S Sayaki Ishiwata