Exploring prognostic factors on vascular outcomes among maintenance dialysis patients and establishing a prognosis prediction model using machine learning methods

No abstractBMC Med Inform Decis Mak. 2025 Dec 5. doi: 10.1186/s12911-025-03302-2. Online ahead of print.NO ABSTRACTPMID:41351012 | DOI:10.1186/s12911-025-03302-2

C Chung-Kuan Wu

Effects of finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 diabetes and chronic kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR)

Cardiovasc Diabetol. 2025 Dec 5;24(1):454. doi: 10.1186/s12933-025-03014-x.ABSTRACTBACKGROUND: The mechanisms underlying cardiorenal benefits of finerenone remain unclear. This mechanistic trial aimed to evaluate the effects of finerenone on vascular stiffness, as assessed using the cardio-ankle vas

A Atsushi Tanaka

The relationship between Non-HDL/HDL ratio and in-stent restenosis in patients with coronary artery atherosclerosis after percutaneous coronary intervention

BMC Cardiovasc Disord. 2025 Dec 5. doi: 10.1186/s12872-025-05400-5. Online ahead of print.ABSTRACTBACKGROUND: Although percutaneous coronary intervention (PCI) is an effective treatment for coronary artery disease (CAD). However, the occurrence of in-stent restenosis (ISR) remains a critical issue i

L Liyu Chen

All-cause and cause-specific mortality in older people with and without diabetes in Norwegian home care services: a nationwide registry study

BMC Geriatr. 2025 Dec 5;25(1):999. doi: 10.1186/s12877-025-06685-z.ABSTRACTBACKGROUND: As the number of older people living at home increases, the role of home care services (HCS) becomes more important. Diabetes is associated with premature mortality and is common among older people in HCS, yet mor

T Tonje Teigland

Assessing the impact of educational intervention based on a health belief model to modify cardiovascular disease risk factors among Egyptian University administrative staff: a quasi-experimental study

BMC Cardiovasc Disord. 2025 Dec 5. doi: 10.1186/s12872-025-05359-3. Online ahead of print.ABSTRACTBACKGROUND: Globally, cardiovascular diseases (CVDs) are acknowledged as a primary cause of death and morbidity. Using the health belief model (HBM) can help individuals believe in adopting a healthy li

A Abeer H Ahmed

Transdermal Drug Delivery Systems: A Comprehensive Review of Mechanisms, Technologies, and Clinical Applications

Pharm Res. 2025 Dec 5. doi: 10.1007/s11095-025-03962-9. Online ahead of print.ABSTRACTBACKGROUND: Transdermal Drug Delivery Systems (TDDS) offer a non-invasive route for sustained systemic or localized drug delivery. By bypassing hepatic first-pass metabolism and improving bioavailability, TDDS enha

F Fengxia Xu

Mechanisms and treatment modalities related to premature ovarian insufficiency in mitochondria: literature review

J Ovarian Res. 2025 Dec 6. doi: 10.1186/s13048-025-01915-9. Online ahead of print.ABSTRACTPremature ovarian insufficiency (POI) is a common, heterogeneous disorder that affects up to 3.5% of women under 40 years of age and is defined by oligo/amenorrhoea, hypo-oestrogenism, and markedly elevated gon

H Huihui Li

Early comparison of one-year outcomes after aortic mechanical vs. biological valve replacement in Chinese patients with small aortic annulus

J Cardiothorac Surg. 2025 Dec 5;20(1):451. doi: 10.1186/s13019-025-03614-4.ABSTRACTBACKGROUND: This study compares short-term clinical and hemodynamic outcomes of AVR using mechanical versus bovine pericardial valves in patients with a small aortic annulus (≤ 21 mm) and evaluates the feasibility and

Y Yu Sun

High salt intake and its dual impact on obesity and cardiovascular mortality in individuals over 50: a paradoxical relationship

BMC Public Health. 2025 Dec 5. doi: 10.1186/s12889-025-25342-z. Online ahead of print.ABSTRACTBACKGROUND: There is still debatable of the optimal standards for obesity and salt intake, particularly their potential impacts on mortality among older population. This study aimed to characterized the com

Y Yushuang Luo

Polystyrene nanoplastics disrupt epididymal initial segment by perturbing NK cell differentiation and epithelial homeostasis

J Nanobiotechnology. 2025 Dec 5. doi: 10.1186/s12951-025-03892-z. Online ahead of print.ABSTRACTSpermatozoa exit the testis in an immotile and immature state, and obtain motility and maturity in the epididymis with the most abundant functions acquired in its initial segment (IS). The reshaping of po

T Tong Chen

Research progress in molecular targeted therapy for inflammatory bowel disease

J Transl Med. 2025 Dec 5. doi: 10.1186/s12967-025-07385-3. Online ahead of print.ABSTRACTINTRODUCTION: Inflammatory Bowel Disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is increasingly prevalent in China. Traditional treatments often have limited efficacy and safety, w

N Nan Liu

Ambient PM(2.5) and O(3) and their combined effects on the onset of acute cardiovascular events: a time-stratified case-crossover study in Jining, China (2015-2023)

CONCLUSIONS: PM(2.5) and O(3) are risk factors for ACE onset, particularly on the day of onset and the day before. Moreover, we found no significant interaction of PM(2.5) and O(3) on ACE onset. Reducing PM(2.5) and O(3) concentrations and avoiding exposure to high levels of these pollutants in the

S Si-Hao Song

Cross-sectional evaluation of exposure to ozone, nitrogen dioxide, and particulate mass levels on circulating immune markers in women in the California Teachers Study

Exposure to ambient air pollutants, specifically ozone (O(3)), nitrogen dioxide (NO(2)), ultrafine, fine or coarse particulate matter (PM(0.1), PM(2.5), and PM(10)), has been linked to a number of adverse health outcomes, including cardiovascular disease. Changes in immune response may be a key mech

E Emily L Cauble

Patient-reported outcomes and perceived medication confidence as predictors of healthcare utilization among adults with cardiovascular risk factors

Sci Rep. 2025 Dec 5. doi: 10.1038/s41598-025-31255-z. Online ahead of print.ABSTRACTThis study examined the association between patient-reported outcomes (PROs), medication-taking confidence, sociodemographic characteristics, and the frequency of 90-day hospital and emergency department (ED) visits

A Arinze Nkemdirim Okere

Expanding insights from the VISTA phase III trial: longitudinal comparative assessment of ellipsoid zone integrity and volumetric fluid dynamics

Sci Rep. 2025 Dec 5;15(1):43222. doi: 10.1038/s41598-025-27350-w.ABSTRACTDiabetic macular edema (DME) is a major cause of visual impairment, and treatment response can vary based on retinal structural changes. This post-hoc analysis of the Phase III VISTA trial evaluated ellipsoid zone (EZ) integrit

K Karen Matar

NF-κB/ICAM-1 signaling regulates vascular dysfunction in depressive hypertension rats

Sci Rep. 2025 Dec 5;15(1):43221. doi: 10.1038/s41598-025-27188-2.ABSTRACTThe relationship between depression and hypertension has garnered increasing scholarly attention, particularly regarding the role of depression in exacerbating organ damage in hypertensive individuals. Inflammation is a key cha

Z Zhimin Liao

Acute type A aortic dissection rupture factors prediction using a hybrid ensemble model with feature selection and data augmentation

No abstractSci Rep. 2025 Dec 5. doi: 10.1038/s41598-025-30529-w. Online ahead of print.NO ABSTRACTPMID:41350571 | DOI:10.1038/s41598-025-30529-w

L Lin Junyao

Adherence to the healthy nordic food index is associated with favorable obesity-related cardiometabolic risk factors among apparently healthy obese individuals

Sci Rep. 2025 Dec 5. doi: 10.1038/s41598-025-30482-8. Online ahead of print.ABSTRACTLimited reports have highlighted the protective role of Healthy Nordic Food Index (HNFI) score against several chronic diseases like cancers and cardiovascular disorders. However, its beneficial role in obesity-relat

N Negin Nikrad

Tenascin-C from the tissue microenvironment promotes muscle stem cell maintenance and function through Annexin A2

Commun Biol. 2025 Dec 5;8(1):1709. doi: 10.1038/s42003-025-09189-z.ABSTRACTSkeletal muscle regeneration occurs through the finely timed activation of resident muscle stem cells (MuSC). Following injury, MuSC exit quiescence, undergo myogenic commitment, and regenerate the muscle. This process is coo

A Alessandra Cecchini

Identification and experimental validation of biomarkers associated with macrophages in myocardial ischemia-reperfusion injury

Sci Rep. 2025 Dec 5;15(1):43241. doi: 10.1038/s41598-025-27301-5.ABSTRACTMyocardial ischemia-reperfusion injury (MIRI) is a complex process leading to substantial myocardial damage. Macrophages play a pivotal role in tissue development and homeostasis. This study aimed to identify macrophage-associa

X Xiaojie Jiang

Lymphocyte trajectories as prognostic indicators in intracerebral hemorrhage: a MIMIC-IV cohort study

Sci Rep. 2025 Dec 5;15(1):43248. doi: 10.1038/s41598-025-27172-w.ABSTRACTTo examine the association between lymphocyte count trajectories and clinical outcomes in patients with spontaneous intracerebral hemorrhage (ICH) using data from the MIMIC-IV database. Patients with spontaneous ICH and at leas

Z Zongren Zhao

Nut consumption and risk of cardiovascular disease events and all-cause mortality: A systematic review and dose-response meta-analysis of prospective cohort studies

Arch Cardiovasc Dis. 2025 Sep 19:S1875-2136(25)00465-6. doi: 10.1016/j.acvd.2025.08.010. Online ahead of print.ABSTRACTBACKGROUND: Evidence for the effects of nut consumption on cardiovascular disease (CVD) events and all-cause mortality has been reported inconsistently.AIMS: To assess the associati

M Mengna Liu

Prevalence, incidence, and occupational risk markers of dyslipidemia in Peruvian workers

Endocrinol Diabetes Nutr (Engl Ed). 2025 Dec 4:501672. doi: 10.1016/j.endien.2025.501672. Online ahead of print.ABSTRACTINTRODUCTION: Dyslipidemias are a significant risk factor for cardiovascular diseases. In Peru, nutritional transition and lifestyle changes may be contributing to an increase in t

J Jhosmer Ballena-Caicedo

The neuro-cardiac axis in epilepsy

Eur J Intern Med. 2025 Dec 4:106631. doi: 10.1016/j.ejim.2025.106631. Online ahead of print.ABSTRACTEpilepsy is a major noncommunicable neurological disorder, most prevalent among patients with cardiovascular (CV) disease (CVD). Epilepsy incurs a higher risk for developing CVD with an odds ratio of

T Theodora A Manolis