Integrated phenotyping identifies reproducible prognostic subgroups in idiopathic pleuroparenchymal fibroelastosis

Respir Res. 2026 Jun 26. doi: 10.1186/s12931-026-03780-6. Online ahead of print.ABSTRACTBACKGROUND: Idiopathic pleuroparenchymal fibroelastosis (PPFE) is a rare interstitial lung disease characterized by upper-lobe-predominant fibrosis and heterogeneous prognosis. An integrated phenotype classificat

R Ryota Otoshi

Multifunctional nano-platform for precision treatment of acute lung injury via synergistic anti-inflammation and oxidative stress modulation

J Nanobiotechnology. 2026 Jun 26. doi: 10.1186/s12951-026-04690-x. Online ahead of print.ABSTRACTAcute lung injury (ALI) remains life-threatening conditions lacking effective disease-modifying therapies. Dysregulated inflammation, oxidative stress, and apoptosis form a self-amplifying pathogenic loo

Y Yongguo Xie

Doctor-nurse integrated management is associated with improved clinical outcomes in AECOPD patients with multimorbidity: A propensity score-matched retrospective cohort study

BMC Pulm Med. 2026 Jun 26. doi: 10.1186/s12890-026-04428-3. Online ahead of print.ABSTRACTBACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are frequently complicated by multimorbidity, particularly cardiovascular and metabolic disorders such as heart failure and diab

L Li Wang

Prevalence of overt hypothyroidism and subclinical hypothyroidism in metabolic syndrome: a systematic review and meta-analysis

BMC Endocr Disord. 2026 Jun 26. doi: 10.1186/s12902-026-02376-x. Online ahead of print.ABSTRACTBACKGROUND: Thyroid hormones regulate insulin sensitivity and lipid metabolism, both of which are central to metabolic syndrome (MetS). While previous systematic reviews have identified an association betw

A Arman Shekarian

Associations of cumulative exposure and longitudinal change patterns of the triglyceride glucose-Chinese visceral adiposity index with incident cardiovascular disease in middle-aged and older adults: evidence from CHARLS

Cardiovasc Diabetol. 2026 Jun 26. doi: 10.1186/s12933-026-03258-1. Online ahead of print.ABSTRACTBACKGROUND: The triglyceride glucose-Chinese visceral adiposity index (TyG-CVAI), an integrated marker of insulin resistance and visceral adiposity, has been associated with cardiovascular outcomes. Howe

H Huilin Liu

Association between asymmetric dimethylarginine level and central obesity among patients with acute myocardial infarction: exploratory cross-sectional study

BMC Cardiovasc Disord. 2026 Jun 26. doi: 10.1186/s12872-026-06178-w. Online ahead of print.ABSTRACTBACKGROUND: Asymmetric dimethylarginine (ADMA), a competitive inhibitor of endothelial nitric oxide synthase (eNOS), has been implicated in atherosclerotic cardiovascular disease. However, the prognost

I Ihab A Naser

SGLT2 Inhibitors in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: A Translational Synthesis From Molecular Pathways to Clinical Potential

No abstractInt J Rheum Dis. 2026 Jul;29(7):e70747. doi: 10.1111/1756-185x.70747.NO ABSTRACTPMID:42363023 | DOI:10.1111/1756-185x.70747

M Mislav Radić

The impact of interleukin-6 receptor inhibitors on risk of diabetes mellitus in patients with giant cell arteritis: a cohort study

Rheumatol Int. 2026 Jun 26;46(7):170. doi: 10.1007/s00296-026-06189-y.ABSTRACTTo investigate the one-year incidence of diabetes mellitus (DM) among patients with giant cell arteritis (GCA) treated with glucocorticoids and interleukin-6 receptor inhibitor (IL-6Ri) compared to patients treated with gl

M Mads E R Sørensen

Racial and Ethnic Disparities in Multimorbidity in Emergency Department Visits: A Latent Class Analysis by Intellectual and Developmental Disability Status in the United States

J Racial Ethn Health Disparities. 2026 Jun 26. doi: 10.1007/s40615-026-03077-w. Online ahead of print.ABSTRACTINTRODUCTION: Multiple chronic conditions (MCC) impose a substantial burden on emergency department (ED) systems in the United States, yet little is known about how patterns of chronic disea

H Hussaini Zandam

Correction to: SIRT3 activation protects from nabumetone-induced mitochondrial toxicity in adult human cardiomyocytes

No abstractCell Mol Life Sci. 2026 Jun 26;83(1):263. doi: 10.1007/s00018-026-06288-w.NO ABSTRACTPMID:42362887 | DOI:10.1007/s00018-026-06288-w

Y Yafei Huang

Cliramitug for depletion of cardiac amyloid transthyretin: long-term follow-up of the NI006-101 trial

Nat Med. 2026 Jun 26. doi: 10.1038/s41591-026-04487-3. Online ahead of print.ABSTRACTIn a first-in-human trial (NI006-101), the monoclonal antibody cliramitug, targeting misfolded transthyretin, demonstrated a favorable safety profile and time- and dose-dependent reductions in surrogate markers of c

P Peter C Kahr

Perspectives on phenotype in genetic testing for early-onset atrial fibrillation

No abstractEur J Hum Genet. 2026 Jun 26. doi: 10.1038/s41431-026-02163-1. Online ahead of print.NO ABSTRACTPMID:42362803 | DOI:10.1038/s41431-026-02163-1

L Leonoor F J M Wijdeveld

Interference resistant contactless heart rate variability monitoring via millimeter wave radar

Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-59339-4. Online ahead of print.ABSTRACTHeart rate variability (HRV) plays a critical role in the prediction of diseases related to cardiovascular and autonomic nervous system. HRV monitoring using millimeter-wave radar has been exploited as a promising r

T Tao Li

20/ (fasting C-peptide × fasting plasma glucose) as a novel marker for insulin resistance in obese children and adolescents

Pediatr Res. 2026 Jun 26. doi: 10.1038/s41390-026-05251-6. Online ahead of print.ABSTRACTBACKGROUND: Insulin resistance (IR) constitutes a critical pathophysiological mechanism linking pediatric obesity to type 2 diabetes mellitus (T2DM) and cardiovascular disease. Recent investigations in adult pop

D Doaa El Amrousy

HeartMap charts new territory in cardiac disease biology

No abstractNat Cardiovasc Res. 2026 Jun 26. doi: 10.1038/s44161-026-00835-1. Online ahead of print.NO ABSTRACTPMID:42362694 | DOI:10.1038/s44161-026-00835-1

D David W Staudt

An integrated cell atlas of 2.4 million cardiac cells across 209 individuals in health and disease

Nat Cardiovasc Res. 2026 Jun 26. doi: 10.1038/s44161-026-00831-5. Online ahead of print.ABSTRACTCardiovascular disease remains the leading cause of global mortality. Understanding its complexity requires dissecting the heart's cellular landscape. Here we present HeartMap, a comprehensive single-nucl

Y Yesh Datar

Killip class at presentation and immediate versus staged multivessel PCI in patients with STEMI

Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-58258-8. Online ahead of print.ABSTRACTPatients with ST-segment elevation myocardial infarction (STEMI) and higher Killip class are at an increased risk of death. We sought to assess outcomes of an immediate or staged multivessel percutaneous coronary in

P Philipp Jakob

Differential functional and lipidomic impact of tofacitinib and other disease-modifying antirheumatic drugs on HDL in rheumatoid arthritis

Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-58152-3. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) presents atheroprotective functions that can be impaired in patients with chronic inflammatory disease, such as rheumatoid arthritis (RA). We investigated the effects of different dise

E Eftaxia-Konstantina Valanti

Bisphenol A induces a pro-angiogenic-like phenotype via the G protein-coupled receptor 30 (GPR30) pathway

Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-54624-8. Online ahead of print.ABSTRACTEndocrine disruptors (EDs) are a group of environmental contaminants known to interfere with hormonal signaling. Among them, Bisphenol A (BPA) widely used in plastic manufacturing enters human bodies mainly through

V Viviana M Bimonte

Cardiovascular-diabetes-stroke multimorbidity patterns are differentially associated with cognitive trajectories in older Chinese adults

Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-56973-w. Online ahead of print.ABSTRACTTo identify multimorbidity patterns using latent class analysis (LCA) and examine their associations with cognitive trajectories among older Chinese adults. This longitudinal study utilized data from the China Healt

K Ke Pei

Daylight saving time transition and new-onset retinal vascular disease: a nationwide cohort study

Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-55281-7. Online ahead of print.ABSTRACTDaylight saving time (DST) transitions lead to disruptions in circadian rhythm, and studies have identified an association between DST transitions and cardiovascular events. Changes in retinal microvasculature can r

K Kyle S Chan

Association between socioeconomic position and transitions to multimorbidity involving major chronic diseases in Northwest Italy

NPJ Aging. 2026 Jun 26. doi: 10.1038/s41514-026-00435-0. Online ahead of print.ABSTRACTMultimorbidity, the co-occurrence of multiple chronic conditions in individuals, complicates clinical management, increases healthcare use, and reduces life quality. This study investigates the association between

F Francesca Mori

Endothelial extracellular vesicles preserve vascular smooth muscle cell identity but do not reverse endothelial senescence

NPJ Aging. 2026 Jun 26. doi: 10.1038/s41514-026-00438-x. Online ahead of print.ABSTRACTVascular aging is characterized by endothelial senescence and vascular smooth muscle cell (VSMC) phenotypic switching, yet the role of endothelial extracellular vesicles (EVs) in these processes remains unclear. W

Ú Úrsula Zúñiga-Cuevas

Retraction Note: Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance

No abstractNat Commun. 2026 Jun 26;17(1):5581. doi: 10.1038/s41467-026-74649-x.NO ABSTRACTPMID:42362533 | DOI:10.1038/s41467-026-74649-x

H Hai Wang