Pharmazie. 2026 May 19;81(5):51803. doi: 10.31083/Pharmazie51803.ABSTRACTDiabetic retinopathy (DR) remains a leading cause of blindness among individuals with diabetes mellitus (DM), with a continuously rising global prevalence. While anti-vascular endothelial growth factor (anti-VEGF) therapy, cort
Pharmazie. 2026 May 28;81(5):51659. doi: 10.31083/Pharmazie51659.ABSTRACTOBJECTIVE: Histone deacetylase 1 (HDAC1) exacerbates ventricular remodeling and heart failure by promoting myocardial peroxidative damage. Thus, this study aimed to investigate whether the HDAC1 inhibitor mocetinostat alleviate
J Integr Neurosci. 2026 May 9;25(5):47725. doi: 10.31083/JIN47725.ABSTRACTBACKGROUND: In this study, we focused on exploring long-term trends and the clinical relevance of brain remodeling in acute basal ganglia cerebral infarction (BGCI) using percent amplitude of fluctuation (PerAF) and dynamic am
J Integr Neurosci. 2026 May 12;25(5):50299. doi: 10.31083/JIN50299.ABSTRACTBACKGROUND: Electron density (ED) imaging has shown the ability to discriminate between different soft tissue components in preliminary studies. We hypothesized that ED might improve the identification of brain tissue abnorma
J Integr Neurosci. 2026 May 26;25(5):48011. doi: 10.31083/JIN48011.ABSTRACTBACKGROUND: Protein p62 interacts with Kelch-like ECH-associated protein 1 (Keap1) competitively, triggering the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2) and preventing ferroptosis in SH-SY5Y cells.
Birth Defects Res. 2026 Jun;118(6):e70056. doi: 10.1002/bdr2.70056.ABSTRACTBACKGROUND: This study examined the association between maternal immigrant status and survival of children with congenital heart diseases (CHD) in Ontario, Canada.METHODS: A retrospective population-based cohort study of hosp
Br J Hosp Med (Lond). 2026 May 18;87(5):53981. doi: 10.31083/BJHM53981.ABSTRACTAIMS/BACKGROUND: Phaeochromocytoma is a rare catecholamine-secreting neuroendocrine tumour arising from chromaffin cells of the adrenal medulla or from extra-adrenal paraganglionic tissue, in which case it is termed parag
Br J Hosp Med (Lond). 2026 May 20;87(5):54061. doi: 10.31083/BJHM54061.ABSTRACTAIMS/BACKGROUND: Early neurological deterioration (END) after thrombolysis is a serious complication in acute ischemic stroke (AIS); however, its early identification remains challenging. This study aimed to investigate t
Br J Hosp Med (Lond). 2026 May 20;87(5):54062. doi: 10.31083/BJHM54062.ABSTRACTAIMS/BACKGROUND: Patients with concomitant heart failure (HF) and type 2 diabetes mellitus (T2DM) are at high risk for adverse clinical outcomes. Glycemic variability (GV) has emerged as a crucial metric for assessing dys
Br J Hosp Med (Lond). 2026 May 20;87(5):54067. doi: 10.31083/BJHM54067.ABSTRACTValvular heart disease (VHD) affects millions worldwide and remains a major cause of morbidity and mortality, placing a substantial and growing burden on healthcare systems. Over the past two decades, transcatheter therap
Br J Hosp Med (Lond). 2026 May 22;87(5):54134. doi: 10.31083/BJHM54134.ABSTRACTAIMS/BACKGROUND: Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder characterised by structural or functional abnormalities of the cilia, which prevent proper oscillation. Patients typically present w
Br J Hosp Med (Lond). 2026 May 22;87(5):54135. doi: 10.31083/BJHM54135.ABSTRACTGlobally and within the United Kingdom, there has been an increase in the number of people who inject drugs (PWID). PWID are at increased risk of injection site and systemic infections, which include abscesses, necrotisin
Br J Hosp Med (Lond). 2026 May 22;87(5):54136. doi: 10.31083/BJHM54136.ABSTRACTAIMS/BACKGROUND: Knee hyperextension during walking is a common clinical concern in stroke patients that worsens lower limb dysfunction and reduces quality of life. This condition is commonly managed through repetitive tr
Br J Hosp Med (Lond). 2026 May 22;87(5):54141. doi: 10.31083/BJHM54141.ABSTRACTDespite accounting for a quarter of all UK deaths, atherosclerotic cardiovascular disease (ASCVD) is frequently undertreated in non-specialist hospital care due to the perceived complexity of modern lipid management. This
Clin Cardiol. 2026 Jun;49(6):e70343. doi: 10.1002/clc.70343.ABSTRACTOBJECTIVE: To explore the pre-hospital delay experiences of myocardial infarction patients in China from a patient-centered perspective.BACKGROUND: Pre-hospital delay remains a globally prevalent issue, influenced by subjective and
Front Biosci (Landmark Ed). 2026 May 19;31(5):49006. doi: 10.31083/FBL49006.ABSTRACTCardiovascular diseases (CVDs) are the primary cause of mortality globally. The Global Burden of Disease Study indicates that CVDs account for one-third of all global deaths, with a notable 18.17% increase in their i
Front Biosci (Landmark Ed). 2026 May 22;31(5):47174. doi: 10.31083/FBL47174.ABSTRACTIncreasing evidence suggests that the gut microbiome (GM) may exert a seminal role in the maintenance of host health as well as in the pathogenesis of various illnesses, including cardiovascular disease (CVD) and neu
Front Biosci (Landmark Ed). 2026 May 22;31(5):49588. doi: 10.31083/FBL49588.ABSTRACTDiabetic retinopathy (DR) is increasingly recognized as a complex neurovascular degenerative disorder driven by intertwined immune and metabolic disturbances within the retinal microenvironment. Chronic hyperglycemia
Front Biosci (Landmark Ed). 2026 May 22;31(5):49658. doi: 10.31083/FBL49658.ABSTRACTBACKGROUND: Cardiac hypertrophy is a major pathological feature of various cardiovascular diseases. Owing to the simple cardiac structure, rapid development, and genetic tractability, zebrafish are an ideal model for
Front Biosci (Landmark Ed). 2026 May 26;31(5):47016. doi: 10.31083/FBL47016.ABSTRACTBACKGROUND: Subarachnoid hemorrhage (SAH) represents a severe subtype of hemorrhagic stroke and is associated with unfavorable clinical outcomes. Physical exercise is an effective behavioral intervention that reduces
Front Biosci (Landmark Ed). 2026 May 26;31(5):50495. doi: 10.31083/FBL50495.ABSTRACTBACKGROUND: Pathological calcification of soft tissues is a hallmark of several diseases, including cardiovascular disorders and osteoarthritis. Macrocalcifications formed under pathological conditions share key feat
Compr Physiol. 2026 Jun;16(3):e70152. doi: 10.1002/cph4.70152.ABSTRACTAIM: Chronic intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), contributes to metabolic diseases and enhances associated cardiovascular (CV) complications through oxidative stress and metabolic alterations. W
CNS Neurosci Ther. 2026 Jun;32(6):e70952. doi: 10.1002/cns.70952.ABSTRACTBACKGROUND: The crosstalk between ferroptosis and neuroinflammation plays an important role in the pathogenesis of cerebral ischemia-reperfusion injury. Toosendanin (TSN), a triterpenoid compound, exhibits a wide range of pharm
Eur J Heart Fail. 2026 May 29:xuag175. doi: 10.1093/ejhf/xuag175. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is a leading and increasingly prevalent cause of maternal morbidity and mortality worldwide, with heart failure (HF) representing a major contributor before, during, and after
