WSB.APP/PS1 mice develop age-dependent cerebral amyloid angiopathy, cerebrovascular dysfunction, and white matter deficits

Alzheimers Dement. 2026 Jun;22(6):e71476. doi: 10.1002/alz.71476.ABSTRACTINTRODUCTION: Cerebrovascular deficits, including cerebral amyloid angiopathy (CAA), play a key role in Alzheimer's disease (AD) pathogenesis. Here, we characterize the susceptibility of the WSB/EiJ genetic context to human AD-

O Olivia J Marola

Integrated Genomic and Transcriptomic Analysis Reveals the Genetic Basis and Causal Association Between Obesity and Atrial Fibrillation

Diabetes Obes Metab. 2026 Jun 16. doi: 10.1111/dom.71016. Online ahead of print.ABSTRACTBACKGROUND: Observational studies have shown that obesity is associated with an increased risk of atrial fibrillation (AF), but the underlying genetic mechanisms and direction of causality remain unclear. This st

X Xize Wu

Alleviating Effects of Perioperative Psychological Intervention and Distraction Therapy on Discomfort in Patients Undergoing Combined Minimally Invasive Treatment for Lower Limb Varicose Veins

Ann Ital Chir. 2026 Jun 10;97(6):1026-1033. doi: 10.62713/aic.4579.ABSTRACTAIM: To investigate the alleviating effects of perioperative psychological intervention combined with distraction therapy on discomfort in patients undergoing combined minimally invasive treatment for lower limb varicose vein

Y Yong Wang

Aldosterone excess, blood pressure control, and kidney outcomes in chronic kidney disease: findings from the Cardiovascular and Metabolic Disease Etiology Research Center-High Risk (CMERC-HI) Study

Hypertens Res. 2026 Jun 16. doi: 10.1038/s41440-026-02694-6. Online ahead of print.ABSTRACTBlood pressure (BP) control in chronic kidney disease (CKD) remains suboptimal despite renin-angiotensin system (RAS) blockade, contributing to disease progression. This study examined associations of relative

J Jong Hyun Jhee

Selective titin cleavage disrupts cardiac mechanical homeostasis to drive heart failure and fibrosis

Nat Cardiovasc Res. 2026 Jun;5(6):572-587. doi: 10.1038/s44161-026-00829-z. Epub 2026 Jun 16.ABSTRACTTitin, the largest human protein, forms the elastic sarcomeric backbone, providing passive stiffness and length-dependent activation in cardiomyocytes. Whereas titin mutations cause inherited cardiom

J Johanna K Freundt

Multi-omic analysis of deep learning-derived phenotypes links ophthalmic imaging to cardiovascular and neurological traits

Nat Cardiovasc Res. 2026 Jun;5(6):541-554. doi: 10.1038/s44161-026-00815-5. Epub 2026 Jun 16.ABSTRACTThe eye is a recognized source of biomarkers for cardiovascular and neurodegenerative disease risk. Here we characterize the breadth of these associations and identify biological axes that may mediat

T Thomas H Julian

Circulating lipids are related to longitudinal changes of ATN biomarkers for Alzheimer's disease

Mol Psychiatry. 2026 Jun 16. doi: 10.1038/s41380-026-03626-z. Online ahead of print.ABSTRACTInvestigating the relationship of circulating lipidome profiles with cross-sectional and longitudinal changes of central Alzheimer's disease (AD) biomarkers, including amyloid/tau/neurodegeneration (A/T/N), c

J Jun Pyo Kim

Construction and validation of a nomogram for overall survival prognosis in patients with advanced (stage III/IV) pancreatic cancer

Sci Rep. 2026 Jun 16. doi: 10.1038/s41598-026-54999-8. Online ahead of print.ABSTRACTIn order to provide an additional tool for clinical prognosis evaluation, this research attempts to build a nomogram for predicting the survival of patients with advanced (stage Ⅲ/Ⅳ) pancreatic cancer and to prelimi

D Dongqi Yang

Targeting intracellular cholesterol imbalance rescues sarcomere-ER contact site signaling and ER remodeling in dilated cardiomyopathy

Signal Transduct Target Ther. 2026 Jun 17;11(1):237. doi: 10.1038/s41392-026-02731-3.ABSTRACTDysregulated intracellular lipid metabolism emerged as a driver of heart failure (HF), a leading cause of death worldwide that is frequently caused by dilated cardiomyopathy (DCM). Yet, how defective lipid s

N Nadezda Ignatyeva

Age- and Sex-specific Prevalence, Longitudinal Trends and Factors of Cardiovascular-Kidney-Metabolic Syndrome Stages among Chinese Adults

NPJ Aging. 2026 Jun 16. doi: 10.1038/s41514-026-00428-z. Online ahead of print.ABSTRACTCardiovascular-Kidney-Metabolic (CKM) syndrome is uncharacterized in Chinese adults across ages, including centenarians. From three cohorts, age- and sex-standardized CKM prevalence showed nearly 90% stage≥1 and >

Z Zhiyue Liang

The association of ABCB1, CYP2C19 and CYP2C9 combined activity with clopidogrel resistance in patients with recurrent ischemic stroke

Pharmacogenomics J. 2026 Jun 16;26(3):28. doi: 10.1038/s41397-026-00421-5.ABSTRACTClopidogrel therapy is recommended to prevent recurrent ischemic stroke. However, clopidogrel resistance exists. This study examines which enzymes are involved in clopidogrel resistance. The study group includes 402 ne

B Birgit Deiman

Characteristics, treatment regimens, and outcomes of patients with true extramedullary multiple myeloma: a real-world monocentric analysis

Ann Hematol. 2026 Jun 16;105(7):300. doi: 10.1007/s00277-026-07118-6.ABSTRACTDespite substantial therapeutic advances in multiple myeloma (MM), extramedullary disease (EMD) remains an aggressive subtype associated with poor prognosis, for which consensus on management is lacking and dedicated clinic

M Marie Harzer

Atrial natriuretic peptide can be biomarker for predicting atrial fibrillation in embolic stroke of undetermined source

Neurol Sci. 2026 Jun 17;47(7):571. doi: 10.1007/s10072-026-09180-4.ABSTRACTPURPOSE: Atrial fibrillation (AF) drives cardioembolic stroke, yet paroxysmal AF (PAF) often escapes detection in embolic stroke of undetermined source (ESUS). We evaluated whether atrial natriuretic peptide (ANP) can identif

Y Yuya Kobayashi

Risk management plan adherence and clinical outcomes in patients receiving targeted therapies

Clin Rheumatol. 2026 Jun 16. doi: 10.1007/s10067-026-08152-5. Online ahead of print.ABSTRACTBACKGROUND: The expanding use of biologic and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs) has substantially improved outcomes in autoimmune diseases but is accompanied by c

L Li-Fong Wang

Nuclear export of R-loop by the DDX1 and XPO1 complex promotes senescence-associated secretory phenotype and inflammaging

Nat Aging. 2026 Jun 16. doi: 10.1038/s43587-026-01147-6. Online ahead of print.ABSTRACTCellular senescence contributes to inflammaging in part through the senescence-associated secretory phenotype (SASP). R-loops, three-stranded nucleic acid structures, contribute to innate immune response in cancer

X Xue Hao

Role of systemic and epicardial adipose tissue in cardiometabolic disease

Nat Rev Cardiol. 2026 Jun 16. doi: 10.1038/s41569-026-01304-9. Online ahead of print.ABSTRACTAdipose tissue is increasingly recognized as an immunological and metabolic organ composed of multiple specialized depots that exert diverse effects on cardiometabolic health. Beyond total adiposity, the dis

S Shaun Khanna

Associations of the CHG index combined with obesity indicators with cardiovascular disease in early CKM syndrome using CHARLS data

Sci Rep. 2026 Jun 16. doi: 10.1038/s41598-026-57748-z. Online ahead of print.ABSTRACTThe cholesterol-high-density lipoprotein-glucose (CHG) index reflects integrated lipid and glucose metabolism, yet its predictive value for cardiovascular disease (CVD) within the cardiovascular-kidney-metabolic (CK

L Luo Lv

Exploring the link between diabetes duration and cardiovascular disease in patients with type 2 diabetes

Sci Rep. 2026 Jun 16. doi: 10.1038/s41598-026-53714-x. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) is strongly associated with cardiovascular disease (CVD). This study aimed to examine the association between diabetes duration and major cardiovascular outcomes, including coronary a

M Methavee Poochanasri

Non-receptor tyrosine kinase signaling pathways and therapeutic implications

Signal Transduct Target Ther. 2026 Jun 16;11(1):235. doi: 10.1038/s41392-026-02729-x.ABSTRACTCell signaling regulates cellular physiological functions, including the cell cycle, survival, immune response, gene expression, and protein-protein interactions. Within this complex system and its intrinsic

M M D Anwar Hossain

Whole blood epigenomic and transcriptomic characterization identifies vulnerable molecular subtypes of chronic coronary disease

Nat Commun. 2026 Jun 16. doi: 10.1038/s41467-026-73815-5. Online ahead of print.ABSTRACTChronic coronary disease (CCD) remains a leading cause of morbidity and mortality worldwide. However, current clinical assessments, including tests of inducible ischemia or coronary artery disease severity poorly

M Matthew Muller

Noninvasively Evaluating the Cerebral Blood Flow Changes After Surgery in Adult Moyamoya Patients Using 3D Pulsed Arterial Spin Labelling MRI

Clin Exp Pharmacol Physiol. 2026 Jun;53(6):e70141. doi: 10.1111/1440-1681.70141.ABSTRACTPURPOSE: To explore the feasibility of phase contrast (PC) MRI and three-dimensional pulsed arterial spin labelling (3D PASL)-MRI in assessing cerebrovascular blood flow changes after surgical revascularization i

Z Zhenfang Zhu

Association of metabolic and bariatric surgery and risk of cognitive impairment among U.S. adults

Surg Obes Relat Dis. 2026 May 19:S1550-7289(26)00698-2. doi: 10.1016/j.soard.2026.05.017. Online ahead of print.ABSTRACTBACKGROUND: Evidence suggests metabolic health plays a significant role in long-term cognitive outcomes. Whether this association stems from weight loss operations or other factors

K Konmal Ali

Acute severe mitral regurgitation mimicking pneumonia: the diagnostic value of echocardiography

BMJ Case Rep. 2026 Jun 16;19(6):e274025. doi: 10.1136/bcr-2026-274025.ABSTRACTAcute hypoxaemic respiratory failure is frequently attributed to primary pulmonary pathology, particularly in the presence of radiographic abnormalities and inflammatory markers. Cardiac conditions, however, may present wi

M Mariana Martins Teixeira

Carotid-femoral pulse wave velocity improves cardiovascular risk prediction beyond SCORE2 in autoimmune rheumatic diseases: a 7-year follow-up study

RMD Open. 2026 Jun 16;12(2):e006847. doi: 10.1136/rmdopen-2026-006847.ABSTRACTOBJECTIVES: To evaluate the prognostic value of carotid-femoral pulse wave velocity (cfPWV), a marker of aortic stiffness, for cardiovascular events (CVEs) in patients with autoimmune rheumatic diseases (ARDs) and to compa

K Konstantinos Triantafyllias