Phenotypic clustering of atrial fibrillation patients using latent class analysis and its potential utility for ablation strategy: insights from the DIRECT-Extend and EARNEST-PVI studies

Eur Heart J Open. 2026 Sep 8;6(5):oeag135. doi: 10.1093/ehjopen/oeag135. eCollection 2026 Sep.ABSTRACTAIMS: AF is a heterogeneous syndrome. We aimed to assess whether latent class analysis (LCA) can identify phenotypes that stratify prognosis and predict differential responses to catheter ablation s

S Shun Sasaki

Efficacy of Vitamin E Administration on Serum Lipid Profile in Adult Patients With Dyslipidemia: A GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis of RCTs

Food Sci Nutr. 2026 Oct 7;14(10):e72428. doi: 10.1002/fsn3.72428. eCollection 2026 Oct.ABSTRACTDyslipidemia is a major risk factor for cardiovascular disease. Studies have shown that vitamin E has therapeutic effects on lipid metabolism; however, findings remain inconsistent. This meta-analysis aims

M Mehdi Karimi

Building the cancer research workforce through implementation of the RACE21 undergraduate cancer research and education program

Discov Educ. 2026;5(1):1127. doi: 10.1007/s44217-026-02251-w. Epub 2026 Oct 6.ABSTRACTBACKGROUND: Cancer remains the second leading cause of death in the state of Alabama and disproportionately affects communities that are rural, of lower socioeconomic status, and individuals with high-risk, predisp

M Michelle S Johnson

Beyond the Cell: Stem Cell-Derived Exosomes as Next-Generation Tools in Regenerative Therapy

Stem Cells Int. 2026 Oct 7;2026:1054968. doi: 10.1155/sci/1054968. eCollection 2026.ABSTRACTExosomes derived from stem cells have gained significant interest in recent years due to their considerable promise as a cell-free therapy in drug delivery and regenerative medicine. Their therapeutic appeal

H Hazem A El-Kady

Free triiodothyronine in intracranial aneurysms: a sex-specific association with unruptured disease and a non-thyroidal illness signal after rupture

Front Neurol. 2026 Sep 23;17:1873351. doi: 10.3389/fneur.2026.1873351. eCollection 2026.ABSTRACTINTRODUCTION: Thyroid dysfunction has been implicated in neurovascular pathologies, but its role in intracranial aneurysm formation and rupture is uncertain. Materials and.METHODS: This is a retrospective

M Maximilian Bschorer

Applying human-centered design to identify needs and generate recommendations to inform an integrated maternal health demonstration model

Front Public Health. 2026 Sep 23;14:1936761. doi: 10.3389/fpubh.2026.1936761. eCollection 2026.ABSTRACTBACKGROUND: Maternal mortality continues to rise in concerning rates in the United States. Maternal mortality risks are increased by clinical factors like cardiovascular disease or infection and no

A Amanda Castelo Saragosa

Development and validation of an interpretable machine learning model for pulmonary heart disease in patients with pneumoconiosis

Front Public Health. 2026 Sep 23;14:1952855. doi: 10.3389/fpubh.2026.1952855. eCollection 2026.ABSTRACTBACKGROUND: Pneumoconiosis patients with pulmonary heart disease (PHD) face an elevated risk of mortality. Early identification of individuals at higher risk of PHD is important for timely risk str

Y Yifei Xie

Biological characterization of a clinical human adenovirus type 3 isolate with oncolytic potential

Front Microbiol. 2026 Sep 23;17:1912909. doi: 10.3389/fmicb.2026.1912909. eCollection 2026.ABSTRACTINTRODUCTION: Human adenovirus type 3 (HAdV-3) is a major adenovirus type associated with respiratory infections in China. Despite its clinical importance, the biological characteristics and potential

Z Zhiwei Shen

Association between admission blood urea nitrogen and clinical outcomes in patients with large ischemic stroke undergoing endovascular treatment

Front Neurol. 2026 Sep 23;17:1880623. doi: 10.3389/fneur.2026.1880623. eCollection 2026.ABSTRACTBACKGROUND: This study aimed to investigate the association between admission blood urea nitrogen (BUN) and clinical outcomes in patients with large ischemic stroke undergoing endovascular treatment (EVT)

M Mingrui Zhou

Long noncoding RNA associations with an IFI27-MCEMP1 transcript pattern in Kawasaki disease

Front Immunol. 2026 Sep 23;17:1882860. doi: 10.3389/fimmu.2026.1882860. eCollection 2026.ABSTRACTKawasaki disease (KD) is an acute pediatric vasculitis with risk of coronary artery injury. A two-transcript IFI27-MCEMP1 score has distinguished KD from other febrile illnesses, but its relationship to

F Fang Liu

Effects of exercise training on cardiotoxicity in cancer survivors. A systematic review

F1000Res. 2026 Jul 27;11:497. doi: 10.12688/f1000research.112667.2. eCollection 2022.ABSTRACTBACKGROUND: Cardiotoxicity is a major long-term complication of anti-cancer drugs such as anthracycline and androgen deprivation therapy (ADT). These drugs also impact the quality of life, reduced functional

R Ravindra Reddy C

Incremental value of insulin resistance surrogate indices beyond the CHA2DS2-VASc score for predicting thromboembolic events in patients with chronic heart failure and atrial fibrillation

Front Endocrinol (Lausanne). 2026 Sep 23;17:1954348. doi: 10.3389/fendo.2026.1954348. eCollection 2026.ABSTRACTBACKGROUND: Patients with chronic heart failure (CHF) and atrial fibrillation (AF) are at high risk of thromboembolic events. Although the CHA2DS2-VASc score is widely used for risk stratif

Y Yingli Xie

Development and validation of an interpretable machine learning model for concurrent identification of kinesiophobia in older patients with coronary heart disease after percutaneous coronary intervention

Front Med (Lausanne). 2026 Sep 23;13:1915056. doi: 10.3389/fmed.2026.1915056. eCollection 2026.ABSTRACTBACKGROUND: Kinesiophobia reduces participation in cardiac rehabilitation and impairs exercise adherence among older patients with coronary heart disease (CHD) after percutaneous coronary intervent

Y Yaya Xi

Comparative effectiveness of non-invasive interventions for stage I post-stroke shoulder-hand syndrome: a network meta-analysis of randomized controlled trials

Front Neurol. 2026 Sep 23;17:1932931. doi: 10.3389/fneur.2026.1932931. eCollection 2026.ABSTRACTBACKGROUND: To compare the effectiveness of non-invasive interventions for pain, upper-limb motor function, and activities of daily living in patients with stage I post-stroke shoulder-hand syndrome (SHS)

X Xiao-Zhong Liu

Systematic quantification and removal of host DNA contamination in 16S rRNA gene sequencing

Quant Biol. 2026 Sep 14;14(4):e70055. doi: 10.1002/qub2.70055. eCollection 2026 Dec.ABSTRACT16S ribosomal RNA (rRNA) gene sequencing is a standard tool for microbial community analysis. Challenges can occur, particularly in low-biomass samples, when host DNA triggers off-target amplification. Low-bi

T Till Birkner

Direct Coronary Vascular and Lipidomic Remodeling by Low-Dose GLP-1 Agonist Therapy in Cardiometabolic HFpEF

Res Sq [Preprint]. 2026 Aug 11:rs.3.rs-10630296. doi: 10.21203/rs.3.rs-10630296/v1.ABSTRACTGlucagon-like peptide-1 receptor agonists (GLP-1RAs) reduce major adverse cardiovascular events in patients with type 2 diabetes and obesity[1, 2], but the mechanisms underlying these benefits remain incomplet

D David Lefer

Cuproptosis-related molecular alterations in a neonatal rat model of hypoxic-ischemic brain damage

Front Neurol. 2026 Sep 23;17:1855158. doi: 10.3389/fneur.2026.1855158. eCollection 2026.ABSTRACTBACKGROUND: Copper homeostasis imbalance is closely linked to the progression of various neurological disorders. Cuproptosis, a recently identified form of cell death caused by abnormal intracellular copp

Q Qiqi Gao

Single-Nuclear RNA Sequencing Reveals Regional Specialization and Cellular Interactions in Epicardial and Perivascular Adipose Tissue

bioRxiv [Preprint]. 2026 Aug 28:2026.08.13.744748. doi: 10.64898/2026.08.13.744748.ABSTRACTBACKGROUND: Adipose tissue surrounding the heart and vasculature plays critical roles in cardiovascular homeostasis and disease, yet the cellular and molecular milieu of these depots at single-cell resolution

K Khanh-Van Tran

Health impacts of national and local air pollution control policies targeting electric generating units, mobile sources, and port activities in three US cities

medRxiv [Preprint]. 2026 Aug 10:2026.08.04.26359640. doi: 10.64898/2026.08.04.26359640.ABSTRACTOBJECTIVE: Over the past decades, US policies intended to reduce air pollution emissions from electric generating units (EGUs), mobile sources (e.g., cars and trucks), and port activities have been impleme

H Haisu Zhang

A nomogram prediction model for 30-day mortality risk in severe cerebral infarction patients integrating inflammation-related indicators and APACHE II score

Front Neurol. 2026 Sep 23;17:1918006. doi: 10.3389/fneur.2026.1918006. eCollection 2026.ABSTRACTOBJECTIVE: To explore independent risk factors for 30-day all-cause mortality in severe cerebral infarction and construct a nomogram prediction model incorporating inflammation-related indicators and APAC

Z Zhou Shu

NLRP3 Activation and Impaired TGF-β Anti-Inflammatory Pathways Predict Vascular Risk in PWH on ART

medRxiv [Preprint]. 2026 Aug 10:2026.08.05.26359809. doi: 10.64898/2026.08.05.26359809.ABSTRACTIMPORTANCE: The immune mechanisms driving vascular disease remain incompletely understood. People with HIV (PWH), even during effective antiretroviral therapy (ART), exhibit persistent immune activation an

A Alton S Barbehenn

Circulating Fatty Acid Synthase and Modified Frailty Index-5 Are Additive Predictors of Adverse Outcomes After Elective Vascular Surgery

medRxiv [Preprint]. 2026 Aug 12:2026.08.10.26360144. doi: 10.64898/2026.08.10.26360144.ABSTRACTBACKGROUND: Preoperative risk assessment in vascular surgery relies on clinical scores and lipids that do not capture atherosclerotic disease activity. Circulating fatty acid synthase (cFAS) is a liver-der

M Mohamed Zaghloul

Asymmetric dimethylarginine (ADMA) modulates frequency-dependent muscarinic antagonism of β-adrenergic regulation of rat papillary muscle contractility

Res Sq [Preprint]. 2026 Aug 13:rs.3.rs-10670314. doi: 10.21203/rs.3.rs-10670314/v1.ABSTRACTAccumulating evidence implicates the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) in cardiovascular impairments. Although the detrimental cardiovascular effects of ADMA have la

A Aleksei Averin

Sex differences in sleep regularity and its associations with mortality

medRxiv [Preprint]. 2026 Aug 10:2026.08.06.26359893. doi: 10.64898/2026.08.06.26359893.ABSTRACTIn characterizing sleep and circadian health, the day-to-day regularity of sleep-wake timing strongly predicts health outcomes, outperforming short sleep duration in prospective associations with mortality

M Mark É Czeisler