J Med Food. 2026 Apr 16:1096620X261438295. doi: 10.1177/1096620X261438295. Online ahead of print.ABSTRACTHypercholesterolemia is a major risk factor for cardiovascular disease, necessitating the development of effective and safe lipid-lowering interventions. This study evaluated the antihypercholest
J Cardiovasc Pharmacol Ther. 2026 Jan-Dec;31:10742484261440344. doi: 10.1177/10742484261440344. Epub 2026 Apr 16.ABSTRACTDespite significant advances in the management of myocardial infarction (MI), therapeutic options targeting upstream pathogenic mechanisms remain scarce. This study introduces a n
BackgroundDual antiplatelet therapy (DAPT) with aspirin and potent P2Y(12) inhibitors such as ticagrelor effectively reduces ischemic events but increases bleeding risk. In patients requiring long-term DAPT, switching from ticagrelor to a thienopyridine is often considered to reduce bleeding risk or
Ned Tijdschr Geneeskd. 2026 Apr 15;170:D8798.ABSTRACTA patent foramen ovale (PFO) is present in approximately 25-30% of adults and is usually asymptomatic. However, under conditions of elevated right heart pressure, a PFO can enable right-to-left shunting, allowing venous thrombi to enter the arteri
Eur Heart J. 2026 Apr 16:ehag176. doi: 10.1093/eurheartj/ehag176. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Low-density lipoprotein cholesterol (LDL-C)-lowering therapies are proven effective in atherosclerotic cardiovascular disease (ASCVD), but real-world evidence for proprotein convertas
JACC Case Rep. 2026 Apr 15;31(15):107160. doi: 10.1016/j.jaccas.2026.107160.ABSTRACTBACKGROUND: This study aimed to explore the clinical application of renal denervation (RDN) in patients with refractory hypertension complicated by acute aortic syndrome.CASE SUMMARY: We present a case of a 54-year-o
J Neurochem. 2026 Apr;170(4):e70430. doi: 10.1111/jnc.70430.ABSTRACTIschemic stroke results in sudden blood flow cessation, thus unmet energy requirements. Glycogen stored around peri-microvascular astrocyte end-feet may mediate capillary contractility and cerebral blood flow alterations. Under gluc
J Int Assoc Provid AIDS Care. 2026 Jan-Dec;25:23259582261444131. doi: 10.1177/23259582261444131. Epub 2026 Apr 16.ABSTRACTIntroductionHypertension has emerged as a significant comorbidity among people living with Human Immunodeficiency Virus (HIV). However, the prevalence and determinants of hyperte
Sci Prog. 2026 Apr-Jun;109(2):368504261444470. doi: 10.1177/00368504261444470. Epub 2026 Apr 16.ABSTRACTObjectiveThis study investigates the association between dietary live microbial intake and mortality among obese adults.MethodsFrom the 1999-2018 cycles of the U.S. National Health and Nutrition E
Clin Cardiol. 2026 Apr;49(4):e70304. doi: 10.1002/clc.70304.ABSTRACTOBJECTIVE: The C-reactive protein-triglyceride-glucose index (CTI) reflects systemic inflammation and insulin resistance, but its relationship with coronary artery calcium (CAC) progression remains unclear. This study examined the a
J Am Heart Assoc. 2026 Apr 16:e045304. doi: 10.1161/JAHA.125.045304. Online ahead of print.ABSTRACTBACKGROUND: High salt (HS) intake is a known cardiovascular risk factor, yet the mechanisms linking salt intake to endothelial dysfunction remain unclear. We investigated whether HS induces vascular se
J Am Heart Assoc. 2026 Apr 16:e045947. doi: 10.1161/JAHA.125.045947. Online ahead of print.ABSTRACTBACKGROUND: Cognitive impairment and dementia are common in patients with heart failure, but the relationships between left ventricular (LV) function, cerebral small vessel disease (CSVD), and cognitio
J Am Heart Assoc. 2026 Apr 16:e040875. doi: 10.1161/JAHA.124.040875. Online ahead of print.ABSTRACTBACKGROUND: Upper gastrointestinal bleeding is a severe postoperative complication after coronary artery bypass grafting. We aimed to identify the incidence, predictors, and outcomes of nonvariceal upp
J Am Heart Assoc. 2026 Apr 16:e046180. doi: 10.1161/JAHA.125.046180. Online ahead of print.ABSTRACTBACKGROUND: As transcatheter aortic valve replacement (TAVR) expands to younger, lower-risk populations, the need for repeat procedures due to valve degeneration is expected to increase. TAVR-in-TAVR h
J Rehabil Med. 2026 Apr 16;58:jrm45503. doi: 10.2340/jrm.v58.45503.ABSTRACTOBJECTIVE: To examine whether early multidimensional mobility assessments discriminate independent ambulation and functional independence on discharge in subacute stroke inpatients with supervised walking ability.DESIGN: Retr
J Am Heart Assoc. 2026 Apr 16:e045788. doi: 10.1161/JAHA.125.045788. Online ahead of print.ABSTRACTBACKGROUND: An effective antithrombotic strategy for patients with univentricular heart is required. We determined the prevalence of antithrombotic treatment and survival in patients with Fontan circul
J Am Heart Assoc. 2026 Apr 16:e050147. doi: 10.1161/JAHA.126.050147. Online ahead of print.ABSTRACTNonvalvular cardiovascular device infections, although rare in most cases, represent substantial clinical challenges due to their life-threatening potential and diagnostic complexity. Although infectio
Eur J Endocrinol. 2026 Apr 16:lvag062. doi: 10.1093/ejendo/lvag062. Online ahead of print.ABSTRACTGlucocorticoid withdrawal syndrome (GWS) is a frequent and clinically significant consequence of reducing chronic endogenous or exogenous glucocorticoid exposure. The syndrome presents with a range of s
Portable air cleaners (PACs) can reduce blood pressure (BP) by decreasing fine particulate matter (PM(2.5)) air pollution exposure. However, the effectiveness of a single PAC in a bedroom and the impact on self-measured home BPs over 4 weeks have not been evaluated. We conducted a randomized-order d
Haemophilia. 2026 Apr 16. doi: 10.1111/hae.70274. Online ahead of print.ABSTRACTInherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitativ
Alzheimers Dement. 2026 Apr;22(4):e71384. doi: 10.1002/alz.71384.ABSTRACTINTRODUCTION: Alzheimer's disease and related dementias are influenced by genetic and environmental risk factors. We investigated the relationship between contextual exposures and cognitive outcomes, independent of and in inter
Alzheimers Dement. 2026 Apr;22(4):e71391. doi: 10.1002/alz.71391.ABSTRACTINTRODUCTION: This post hoc analysis of the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial examined associations between dulaglutide, Alzheimer's disease and related dementia (ADRD) biomarke
Mol Nutr Food Res. 2026 Apr;70(8):e70464. doi: 10.1002/mnfr.70464.ABSTRACTDiabetic cardiomyopathy (DCM) results in high mortality with surprisingly rare therapeutic approaches. Anacardic acid (AA) shows broad pharmacological properties, but its effect on DCM was unknown. This study aims to investiga
Genet Med. 2026 Apr 14:102577. doi: 10.1016/j.gim.2026.102577. Online ahead of print.ABSTRACTLoeys-Dietz Syndrome (LDS) represents a clinically and genetically heterogeneous group of connective tissue disorders that share features similar to Marfan syndrome, first identified in 2005. Characterized b
