Uncovering core diseases in temporal trajectories of cardiovascular-kidney-metabolic (CKM) syndrome in UK Biobank: network-based study

No abstractSci Rep. 2026 Apr 21. doi: 10.1038/s41598-026-49572-2. Online ahead of print.NO ABSTRACTPMID:42014907 | DOI:10.1038/s41598-026-49572-2

X Xinyang Long

Remnant cholesterol level modified the effects of intensive systolic blood pressure lowering treatment in high-risk hypertensive patients: a post hoc analysis of the ESPRIT trial

Hypertens Res. 2026 Apr 21. doi: 10.1038/s41440-026-02596-7. Online ahead of print.ABSTRACTWe sought to investigate whether remnant cholesterol (RC) modified the effect of intensive blood pressure (BP) lowering treatment. This study was a post hoc analysis of ESPRIT. In this trial, hypertensive pati

H Haixu Wang

Enhanced multicancer screening assay through whole-genome methylation sequencing-based multimodal cell-free DNA analysis

Exp Mol Med. 2026 Apr 21. doi: 10.1038/s12276-026-01674-7. Online ahead of print.ABSTRACTThe rapid and accurate detection of multiple cancers presents considerable challenges, especially for stage I disease, due to the low concentration and heterogeneous nature of circulating tumor DNA. Here we intr

S Seongmun Jeong

CNDP1 (CTG)(5) allele and cardiovascular events in high-risk patients: LURIC study results

No abstractSci Rep. 2026 Apr 21;16(1):13011. doi: 10.1038/s41598-026-49233-4.NO ABSTRACTPMID:42014802 | DOI:10.1038/s41598-026-49233-4

S Steffen A Hettler

Dataset for studying deformation in 3D patient-specific pulmonary artery anatomies

Sci Data. 2026 Apr 21. doi: 10.1038/s41597-026-07257-5. Online ahead of print.ABSTRACTOptimizing transcatheter pulmonary valve replacement (TPVR) requires biomechanical analysis of the right ventricular outflow tract (RVOT) and pulmonary artery (PA). Despite its importance for device sizing and land

C Camilo E Pérez-Cualtán

Loss of DNA methyltransferase 3a enhances Caspase-8 transcription and promotes cardiomyocyte pyroptosis during myocardial infarction

Nat Commun. 2026 Apr 22. doi: 10.1038/s41467-026-71941-8. Online ahead of print.ABSTRACTAspartate-specific cysteine protease (Caspase)-8 plays a critical role in initiating pyroptosis by mediating cleavage and activation of gasdermin-D (Gsdmd) during Yersinia infection. However, the role of Caspase-

N Ning Wang

Experiences of Adults Managing Cardiovascular Health While in Permanent Supportive Housing (PSH): A Qualitative Study

J Gen Intern Med. 2026 Apr 21. doi: 10.1007/s11606-026-10419-1. Online ahead of print.ABSTRACTBACKGROUND: People experiencing homelessness (PEH) have higher rates of cardiovascular disease (CVD) and cardiovascular (CV)-related deaths than the general population. These deaths may result from modifiab

A Audrey Rose Hyson

Advancing AI for multi-omics and clinical data integration in basic and translational cancer research

Nat Rev Cancer. 2026 Apr 21. doi: 10.1038/s41568-026-00922-2. Online ahead of print.ABSTRACTThe extensive heterogeneity of cancer across biological scales necessitates a holistic approach beyond single-analyte methods. Integrating multi-omics data - from genomics to proteomics - with multimodal info

F Fei Liu

Correction to: Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway

No abstractJ Mol Med (Berl). 2026 Apr 22;104(1):67. doi: 10.1007/s00109-026-02673-x.NO ABSTRACTPMID:42014531 | DOI:10.1007/s00109-026-02673-x

W Wenjiang Yan

Knockout of LCN2 attenuates lung injury and ferroptosis in septic mice likely through inhibiting the TLR4/NF-κB signaling pathway

Sheng Li Xue Bao. 2026 Apr 25;78(2):452-462. doi: 10.13294/j.aps.2025.0070.ABSTRACTThis study aimed to investigate the effects of lipocalin-2 (LCN2) gene knockout (LCN2KO) on cecal ligation and perforation (CLP)-induced lung injury and ferroptosis in septic mice, and further to clarify the potential

Y Yi-Ren Wang

Inhibition of cathepsin K improves the learning and memory function of the vascular dementia model rats through blocking pyroptosis pathway

Sheng Li Xue Bao. 2026 Apr 25;78(2):425-432. doi: 10.13294/j.aps.2026.0033.ABSTRACTThe study aimed to investigate the mechanism of cathepsin K (CatK) on hippocampal learning and memory dysfunction in rats with vascular dementia (VD). Sprague-Dawley (SD) male rats were randomly divided into control g

J Jia-Yao Qiu

Research advances in the role of macrophages in the pathogenesis and treatment of sepsis-induced cardiomyopathy

Sheng Li Xue Bao. 2026 Apr 25;78(2):385-394. doi: 10.13294/j.aps.2026.0032.ABSTRACTSepsis-induced cardiomyopathy (SIC) is a form of myocardial dysfunction induced by sepsis, which significantly increases mortality in septic patients. Its pathogenic mechanisms are highly complex, and there is current

X Xing-Min Ning

The role and mechanism of autophagy regulator mTOR in renal ischemia-reperfusion injury

Sheng Li Xue Bao. 2026 Apr 25;78(2):375-384. doi: 10.13294/j.aps.2025.0106.ABSTRACTRenal ischemia-reperfusion injury (RIRI) is a major cause of acute kidney injury (AKI) and poor kidney transplantation outcomes. Its pathogenesis is closely related to oxidative stress, autophagy, and endoplasmic reti

Q Qian Luo

Mechanism of mitochondrial transcellular transfer in cerebral ischemia-reperfusion injury

Sheng Li Xue Bao. 2026 Apr 25;78(2):295-305. doi: 10.13294/j.aps.2026.0030.ABSTRACTIschemic stroke (IS) is an acute cerebrovascular disease in which blood circulation to brain tissue and neurological function are impaired due to obstruction of cerebral blood vessels, and it is one of the most common

R Rui-Shu An

The role of β2-adrenergic receptors in ischemic stroke

Sheng Li Xue Bao. 2026 Apr 25;78(2):270-282. doi: 10.13294/j.aps.2025.0110.ABSTRACTIschemic stroke is a common cerebrovascular disease with an increasing incidence year by year, and it remains one of the leading causes of death and disability worldwide. The β2-adrenergic receptor (β2-AR), a member o

S Shuang Zhang

Renal sodium transporters in salt-sensitive hypertension

Sheng Li Xue Bao. 2026 Apr 25;78(2):253-269. doi: 10.13294/j.aps.2026.0035.ABSTRACTHypertension is one of the most important risk factors for cardiovascular, cerebrovascular and renal diseases. The molecular mechanism of hypertension is not fully understood largely due to the complexity of pathogene

C Cheng-Bin Tang

Corrigendum to "Targeting HSP90 suppresses STAT1/CCL8-driven inflammation and mitigates mitochondrial dysfunction to attenuate hypertension-induced atrial fibrillation" [Life Sci. 391 (2026) 124279]

No abstractLife Sci. 2026 Apr 20:124399. doi: 10.1016/j.lfs.2026.124399. Online ahead of print.NO ABSTRACTPMID:42014311 | DOI:10.1016/j.lfs.2026.124399

Y Yao Li

10-Year Trends in Lipoprotein(a) Testing in Queensland and Australia: A Retrospective Analysis of Ordering Patterns

Heart Lung Circ. 2026 Apr 20:S1443-9506(26)00051-X. doi: 10.1016/j.hlc.2026.01.007. Online ahead of print.ABSTRACTBACKGROUND: Lipoprotein(a) [Lp(a)] is a genetically determined, highly atherogenic lipoprotein that contributes to cardiovascular disease and calcific aortic valve stenosis. Increased Lp

C Caroline A E Bachmeier

Preoperative Exposure to Sodium-Glucose Cotransporter-2 Inhibitors and Acute Kidney Injury After Cardiac Surgery: A Retrospective Single-Centre Cohort Study With Overlap Weighting Propensity Score Analysis

Heart Lung Circ. 2026 Apr 20:S1443-9506(26)00033-8. doi: 10.1016/j.hlc.2026.01.004. Online ahead of print.ABSTRACTBACKGROUND & AIMS: This study aims to investigate the impact of preoperative sodium-glucose cotransporter 2 inhibitor (SGLT2i) exposure on cardiac surgery-associated acute kidney injury.

M Martin Ruste

Corrigendum to 'Research progress on the regulation of interstitial cell of Cajal autophagy and apoptosis crosstalk by traditional Chinese medicine in gastrointestinal motility disorders'[J. Ethnopharmacol. 2025, 351, 120128]

No abstractJ Ethnopharmacol. 2026 Apr 20:121719. doi: 10.1016/j.jep.2026.121719. Online ahead of print.NO ABSTRACTPMID:42014286 | DOI:10.1016/j.jep.2026.121719

L Lumei Zhang

Plasma PCSK9 levels in children and adolescents: evidence from an Italian outpatient paediatric clinic cohort at cardio-metabolic risk

Nutr Metab Cardiovasc Dis. 2026 Apr 8:104754. doi: 10.1016/j.numecd.2026.104754. Online ahead of print.ABSTRACTBACKGROUND AND AIM: Whether measuring circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) plasma levels in cardiovascular contexts may be of use in the clinical practice remai

M M Ruscica

Cardiometabolic diseases and risk of early-onset dementia: a population-based case-control study in Northern Italy

Nutr Metab Cardiovasc Dis. 2026 Apr 12:104760. doi: 10.1016/j.numecd.2026.104760. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Early-onset dementia (EOD), defined by symptom onset before 65 years, has an uncertain etiology. Cardiovascular and metabolic diseases have been suggested to increase

R Riccardo Mazzoli

The weight of a hug: Abdominal obesity as a barrier to health and human connection

Obes Res Clin Pract. 2026 Apr 20:S1871-403X(26)00030-X. doi: 10.1016/j.orcp.2026.04.003. Online ahead of print.ABSTRACTA hug is a simple act of human connection, yet for many individuals with abdominal obesity, it can be physically challenging and emotionally uncomfortable. This paper examines how a

J Jannatul Ferdous

Epidemiological insights into epiretinal membranes using optical coherence tomography: the Singapore Epidemiology of Eye Diseases Study-2

Br J Ophthalmol. 2026 Apr 21:bjo-2025-327898. doi: 10.1136/bjo-2025-327898. Online ahead of print.ABSTRACTBACKGROUND: To investigate prevalence and risk factors of epiretinal membrane (ERM), particularly those associated with ERM severity, in a multi-ethnic Asian cohort using optical coherence tomog

Y Yanyan Chen