Expression of Apolipoprotein L1 Risk Variants at the Plasma Membrane and Haplotype-Dependent Cytotoxicity
J Am Soc Nephrol. 2026 Jun 15. doi: 10.1681/ASN.0000001159. Online ahead of print.ABSTRACTBACKGROUND: The mechanisms by which apolipoprotein L1 (APOL1) risk variants, G1 and G2, induce kidney disease in individuals of African ancestry remain contentious.METHODS: In this study, we utilized a heterolo

