An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease

Genome Biol. 2026 Apr 6. doi: 10.1186/s13059-026-04061-7. Online ahead of print.ABSTRACTBACKGROUND: As the first organ to develop in utero, the human heart undergoes extensive molecular, structural and metabolic remodeling during development and must sustain its function throughout life.RESULTS: We

W William Gao

Cardiovascular disease risk factors in young people with diabetes mellitus

Cardiovasc Diabetol Endocrinol Rep. 2026 Apr 6;12(1):16. doi: 10.1186/s40842-026-00277-5.ABSTRACTBACKGROUND: The increasing prevalence of diabetes in young adults raises concerns regarding its early cardiometabolic consequences. This study aimed to evaluate cardiac function, renal markers, lipid pro

M Mumtaz Murat Yardimci

Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA)

BMC Med. 2026 Apr 6. doi: 10.1186/s12916-026-04829-5. Online ahead of print.ABSTRACTBACKGROUND: Sarcopenia, the age-related loss of skeletal muscle mass and function, has been linked to adverse health outcomes. Cross-sectional associations have been observed between skeletal and cardiac muscle mass

J Jie Jun Wong

Comparative Efficacy and Safety of Novel Lp(a)-Lowering Therapies for ASCVD Prevention: A Network Meta-Analysis

Pharmacol Res. 2026 Apr 3:108178. doi: 10.1016/j.phrs.2026.108178. Online ahead of print.ABSTRACTElevated lipoprotein(a) [Lp(a)] is a genetically determined and independent risk factor for atherosclerotic cardiovascular disease (ASCVD) that is largely resistant to conventional lipid-lowering therapi

A An-Xin Wu

Multidimensional Care in Transthyretin Cardiac Amyloidosis: Integrating Extracardiac Organ Involvement and Comorbidity Management

Curr Probl Cardiol. 2026 Apr 3:103338. doi: 10.1016/j.cpcardiol.2026.103338. Online ahead of print.ABSTRACTBACKGROUND: Transthyretin amyloidosis (ATTR) is a progressive multisystem disorder caused by extracellular deposition of amyloid fibrils derived from mutant (hATTR) or wild-type (ATTRwt) transt

R Roberta Magnano

7-ketocholesterol as a theranostic target: potential applications and future perspectives

Chem Phys Lipids. 2026 Apr 3:105588. doi: 10.1016/j.chemphyslip.2026.105588. Online ahead of print.ABSTRACT7-Ketocholesterol (7KC) is mainly formed by cholesterol autoxidation and is a pro-oxidant and pro-inflammatory bioactive lipid that also induces different types of cell death, including oxiapop

G Gérard Lizard

Milk-Specific IgE Sensitization and Cardiovascular Outcomes: A Retrospective Cohort Study

Ann Allergy Asthma Immunol. 2026 Apr 3:S1081-1206(26)00147-X. doi: 10.1016/j.anai.2026.03.025. Online ahead of print.ABSTRACTBACKGROUND: Population-based studies have identified an association between milk-specific IgE and cardiovascular (CV) mortality. However, whether this sensitization reflects b

S Sara Davies

Gestational diabetes and subsequent risk of type 2 diabetes and metabolic dysfunction-associated steatotic liver disease in a commercially insured U.S. Pregnancy cohort

Diabetes Res Clin Pract. 2026 Apr 3:113240. doi: 10.1016/j.diabres.2026.113240. Online ahead of print.ABSTRACTAIMS: Gestational diabetes mellitus (GDM) is a common pregnancy complication and marker of subsequent metabolic risk. Whether GDM increases metabolic dysfunction-associated steatotic liver d

L Lili Liu

Comorbidities/cardiovascular risk factors and acute glycaemic emergencies in patients with type 1 and type 2 diabetes: The Australian National Diabetes Audit

Diabetes Res Clin Pract. 2026 Apr 3:113241. doi: 10.1016/j.diabres.2026.113241. Online ahead of print.ABSTRACTAIMS: The prevalence of diabetes, ageing and comorbidity is increasing. This analysis explores the relationship between comorbidities, risk factors and acute glycaemic emergencies.METHODS: T

C Chloe Dawson

Beyond ion channel dysfunction: Integration of the transcriptome and proteome from patient-specific re-engineered cardiac cells, and population-level QT genome-wide association study reveals broad cellular dysfunction

Heart Rhythm. 2026 Apr 3:S1547-5271(26)02147-8. doi: 10.1016/j.hrthm.2026.03.1891. Online ahead of print.ABSTRACTBACKGROUND: Congenital long QT syndrome (LQTS) is a heritable cardiac channelopathy with increased risk of cardiac-triggered syncope/seizures, sudden cardiac arrest, and sudden cardiac de

E Elliana V Rudquist

Imaging Naxos Disease and Related Cardiocutaneous Syndromes: The NAXCARE Multimodality Approach

Hellenic J Cardiol. 2026 Apr 3:S1109-9666(26)00077-1. doi: 10.1016/j.hjc.2026.03.007. Online ahead of print.ABSTRACTNaxos disease and related cardiocutaneous syndromes are rare inherited desmosomal disorders in which characteristic cutaneous features, most notably woolly hair and palmoplantar kerato

I Ioannis Protonotarios

Economic Burden Associated with Systemic Inflammation in Patients with HFmrEF/HFpEF

Am Heart J. 2026 Apr 3:107439. doi: 10.1016/j.ahj.2026.107439. Online ahead of print.ABSTRACTBACKGROUND: Systemic inflammation (SI), detected via high sensitivity C-reactive protein (hsCRP) testing, has a recognized role in the pathogenesis and long-term outcomes in cardiovascular disease. However,

T Taiwo P Adesoba

Effect of the gut microbiota metabolite phenylacetylglycine on cardiac Ca2+ signaling

Biophys Rep (N Y). 2026 Apr 3:100260. doi: 10.1016/j.bpr.2026.100260. Online ahead of print.ABSTRACTPhenylacetylglutamine (PAGln) and phenylacetylglycine (PAGly) are small molecules derived from the metabolism of phenylalanine by gut microbiota. Elevated levels of PAGln and PAGly in serum have been

E Elisa Bovo

Outcomes of Zone 1 Thoracic Endovascular Aortic Repair with Single Branched Stent Graft and Left Common Carotid Artery Chimney Stenting for Zone 2 Aortic Arch Pathologies

Eur J Vasc Endovasc Surg. 2026 Apr 3:S1078-5884(26)00312-6. doi: 10.1016/j.ejvs.2026.03.050. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study was to evaluate the safety and efficacy of an innovative, single stage, two target vessel revascularisation endovascular repair strategy, namely

J Jie Fang

The role of lipoprotein(a) in coronary microvascular dysfunction: Mechanistic pathways, clinical evidence, and therapeutic perspectives

Life Sci. 2026 Apr 3:124371. doi: 10.1016/j.lfs.2026.124371. Online ahead of print.ABSTRACTCoronary microvascular dysfunction (CMD) is increasingly recognized as a major driver of myocardial ischemia, with important implications for cardiovascular prognosis and quality of life, particularly in popul

P Parmis Mansouri

Miscarriage, stillbirth, and pregnancy termination and cardiovascular diseases in midlife women: A longitudinal analysis in the UK Biobank

Public Health. 2026 Apr 4;255:106290. doi: 10.1016/j.puhe.2026.106290. Online ahead of print.ABSTRACTOBJECTIVES: Adverse pregnancy outcomes such as miscarriage and stillbirth have been increasingly recognized as potential early indicators of cardiovascular risk in women. However, evidence remains in

A Alexandre Vallée

The long-term dialysis due to diabetic nephropathy may be associated with in-hospital death in patients with acute myocardial infarction

Heart Vessels. 2026 Apr 5. doi: 10.1007/s00380-026-02686-z. Online ahead of print.ABSTRACTThe clinical outcomes of acute myocardial infarction (AMI) in dialysis patients are poor, and the outcomes may be worse in the long-term dialysis patients due to diabetic nephropathy (DMN). However, there are l

S Shun Ishibashi

Clinical presentation and rehabilitation approaches in patients with ankylosing spondylitis and comorbidities: a multicenter retrospective study

Rheumatol Int. 2026 Apr 6;46(4):72. doi: 10.1007/s00296-026-06098-0.ABSTRACTAnkylosing spondylitis (AS) is a chronic immune-mediated disease characterized by damage to the axial skeleton and a high prevalence of comorbidities that influence disease severity and rehabilitation strategy. Rehabilitatio

A Ainur Issakulova

Association of neovascular glaucoma with increased mortality and cardiovascular risk: a multicenter propensity-matched study

Sci Rep. 2026 Apr 5. doi: 10.1038/s41598-026-46192-8. Online ahead of print.ABSTRACTNeovascular glaucoma (NVG) is a severe, vision-threatening secondary glaucoma associated with ocular ischemia and systemic vascular disease. Whether NVG also serves as a marker of systemic vascular risk remains uncle

Y Yossi Eshel

Long-term prognostic significance of negative CT-derived fractional flow reserve in patients with stable CAD: A meta-analysis of reconstructed time-to-event data

J Cardiovasc Comput Tomogr. 2026 Apr 4:S1934-5925(26)00057-2. doi: 10.1016/j.jcct.2026.03.006. Online ahead of print.ABSTRACTBACKGROUND: Computed tomography-derived fractional flow reserve (CT-FFR) is an emerging tool allowing for noninvasive physiological assessment and risk stratification of patie

R Roozbeh Narimani-Javid

Prognostic value of kidney function biomarkers for target organ injury in young adults stratified by blood pressure status: the African-PREDICT study

Nutr Metab Cardiovasc Dis. 2026 Mar 5:104673. doi: 10.1016/j.numecd.2026.104673. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Kidney function biomarkers are valuable early risk predictors for target organ injury (TOI), yet their prognostic value remains underexplored in young hypertensive adul

A Anja Degenaar

Association of Cardiovascular-Kidney-Metabolic Health With Structural Brain Imaging and the Risk of Specific-Cause Dementia: A Cohort Study

Am J Geriatr Psychiatry. 2026 Mar 10:S1064-7481(26)00299-X. doi: 10.1016/j.jagp.2026.03.205. Online ahead of print.ABSTRACTOBJECTIVES: CKM syndrome may represent the coexistence of multiple risk factors for dementia; however, its large sample-based effects on the risk of specific-cause dementia and

H Heng Zhang

Individual Differences in the Impact of Habitual Alcohol Drinking on Blood Pressure

Nihon Eiseigaku Zasshi. 2026;81. doi: 10.1265/jjh.25010.ABSTRACTHabitual alcohol consumption is an established risk factor for hypertension. To prevent hypertension, daily alcohol consumption is generally recommended to be less than 20-30 ml in men and 10-20 ml in women. The association between alco

I Ichiro Wakabayashi

Subclinical hypothyroidism and height loss in relation to the status of thyroid cysts: a prospective study

Environ Health Prev Med. 2026;31:27. doi: 10.1265/ehpm.25-00458.ABSTRACTBACKGROUND: Despite numerous recent studies linking height loss to the risk of cardiovascular disease, the underlying biological mechanisms are poorly understood. Subclinical hypothyroidism (SCH) has been positively associated w

Y Yuji Shimizu