Prospective Evaluation of Quality-of-Life Improvement After Dapagliflozin Initiation in a Greek Population With HFrEF: The EVOLUTION-HF 12-Month Results

Clin Cardiol. 2026 Sep;49(9):e70466. doi: 10.1002/clc.70466.ABSTRACTINTRODUCTION: Heart failure with reduced ejection fraction (HFrEF), defined by a left ventricular ejection fraction ≤ 40%, remains a major global health challenge, associated with substantial morbidity, mortality, and impaired quali

V Victoria Potoupni

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

NEJM Evid. 2026 Sep 6:EVIDoa2600231. doi: 10.1056/EVIDoa2600231. Online ahead of print.ABSTRACTBACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive.METHODS: This was a

J Josefin Sundh

Treatment of Hypercholesterolemia in Chronic Kidney Disease: Rationale and Therapeutic Approaches from the Non-Dialysis Stage to Kidney Transplantation

G Ital Nefrol. 2026 Aug 31;43(4):2026-vol4. doi: 10.69097/43-04-2026-10.ABSTRACTThroughout the natural history of chronic kidney disease (CKD), most patients experience fatal or non-fatal cardiovascular events. In this review, we address the role of low-density lipoprotein cholesterol (LDL-C) in the

R Roberto Minutolo

Beyond Compensation: Hyperinsulinemia as an Early Driver of Cardiovascular-Kidney-Metabolic Syndrome

G Ital Nefrol. 2026 Aug 31;43(4):2026-vol4. doi: 10.69097/43-04-2026-05.ABSTRACTBackground. Cardiovascular-kidney-metabolic (CKM) syndrome encompasses obesity, type 2 diabetes, cardiovascular disease, and chronic kidney disease. Insulin resistance has traditionally been considered the primary driver

R Rodrigo Daza Arnedo

Public Awareness of Stroke Risk Factors, Warning Symptoms, Prevention Measures, and Stroke Management Among Adults in Two Major Cities in Yemen: A Cross-Sectional Study

Vasc Health Risk Manag. 2026 Sep 1;22:623354. doi: 10.2147/VHRM.S623354. eCollection 2026.ABSTRACTBACKGROUND: Stroke remains a major global health challenge and a leading cause of mortality and long-term disability worldwide. In low-income, conflict-affected countries such as Yemen, the burden is am

N Najmaddin A H Hatem

Nanoparticle-Based Drug Delivery Systems for Periodontitis: Antibacterial, Immunomodulatory, and Regenerative Strategies

Int J Nanomedicine. 2026 Sep 1;21:630550. doi: 10.2147/IJN.S630550. eCollection 2026.ABSTRACTPeriodontitis is a chronic inflammatory disease associated with obesity, type 2 diabetes, and cardiovascular disease, and has become a serious public health issue. Antibacterial treatment and mechanical debr

L Liyan Wang

Changes in Left Ventricular Afterload Following Weaning From Cardiopulmonary Bypass Proved Useful for the Anesthetic Management of Aortic Valve Replacement: A Case Report

Cureus. 2026 Aug 6;18(8):e114078. doi: 10.7759/cureus.114078. eCollection 2026 Aug.ABSTRACTDuring aortic valve replacement, after weaning from the cardiopulmonary bypass (CPB), systemic vascular resistance, which constitutes the left ventricular afterload, fluctuates significantly due to systemic in

K Keisuke Sumii

Tricuspid Valve Infective Endocarditis

Cureus. 2026 Aug 6;18(8):e114058. doi: 10.7759/cureus.114058. eCollection 2026 Aug.ABSTRACTStaphylococcus aureus endocarditis is a severe and life-threatening infection that continues to pose a significant challenge in cardiovascular medicine. Despite advances in healthcare, its management remains c

Z Zahraa M Al Dujaili

Impact of Early Nonfatal Complications After Transcatheter Aortic Valve Implantation on 1-Year Mortality and Quality of Life: Insights From the LANDMARK Trial

Struct Heart. 2026 Jul 24;10(9):101101. doi: 10.1016/j.shj.2026.101101. eCollection 2026 Sep.ABSTRACTBACKGROUND: The impact of early nonfatal complications on subsequent mortality and quality of life (QOL) after contemporary transcatheter aortic valve implantation (TAVI) remains unclear.METHODS: Thi

A Akihiro Tobe

Sex-Specific Differences in Clinical Outcomes After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Reconstructed Individual Patient Survival Data

Struct Heart. 2026 Jul 23;10(9):101100. doi: 10.1016/j.shj.2026.101100. eCollection 2026 Sep.ABSTRACTBACKGROUND: Females with severe aortic stenosis present with distinct anatomical and clinical characteristics compared to males, which may influence outcomes following transcatheter aortic valve repl

A Ali M Abdelaziz

Spatially and temporally resolved assessment of quantitative skeletal muscle perfusion with non-contrast MRI in patients with PAD and healthy controls

Quant Imaging Med Surg. 2026 Sep 1;16(9):727. doi: 10.21037/qims-2026-0675. Epub 2026 Aug 3.ABSTRACTBACKGROUND: Peripheral arterial disease (PAD) is mainly defined by macrovascular obstruction, while microvascular dysfunction remains insufficiently characterized by conventional diagnostics. Arterial

C Caleb Berberet

Quantitative and semi-quantitative comparison of myocardial blood flow between 99mTc-tetrofosmin and 99mTc-sestamibi: based on continuous rapid dynamic imaging technology using cadmium-zinc-telluride cardiac single-photon emission computed tomography

CONCLUSIONS: Under a continuous rapid dynamic acquisition protocol, ^(99m)Tc-TF provides conventional semi-quantitative perfusion parameters and left ventricular functional indices comparable to those obtained with ^(99m)Tc-MIBI, while offering superior MPI image quality. Differences in quantitative

Y Yue Chen

From biomechanical mechanisms to clinical reasoning: Deciphering mechanobiological drivers of aortic valve calcification for precision therapy

Mechanobiol Med. 2026 Aug 22;4(3):100208. doi: 10.1016/j.mbm.2026.100208. eCollection 2026 Sep.ABSTRACTCalcific aortic valve disease (CAVD) is a degenerative cardiovascular disorder characterized by progressive valvular thickening and calcification, ultimately leading to aortic stenosis, heart failu

Y Yefan Jiang

Association of epicardial fat tissue combined with left ventricular strain with left ventricular fibrosis in obese patients: a cardiac magnetic resonance study

Quant Imaging Med Surg. 2026 Sep 1;16(9):692. doi: 10.21037/qims-2026-1-0336. Epub 2026 Aug 5.ABSTRACTBACKGROUND: Obesity is an established independent risk factor for cardiovascular disease, and myocardial fibrosis represents a key pathological mechanism underlying obesity-related cardiac dysfuncti

Y Yuheng Yao

Diagnostic performance of the main pulmonary artery-to-ascending aorta diameter ratio for pulmonary hypertension defined by mean pulmonary arterial pressure in children with left-to-right shunt congenital heart disease

Quant Imaging Med Surg. 2026 Sep 1;16(9):735. doi: 10.21037/qims-2025-1-2760. Epub 2026 Aug 10.ABSTRACTBACKGROUND: The computed tomography (CT)-derived main pulmonary artery-to-ascending aorta diameter ratio (MPA/AA) may identify pulmonary hypertension (PH). In left-to-right (L-R) shunt congenital h

Y Ying Lyu

Comparative effectiveness of GLP-1 receptor agonists versus mineralocorticoid receptor antagonists as fourth-line pharmacological therapy in patients with resistant hypertension and overweight or obesity: a retrospective multicenter cohort study in the USA

EClinicalMedicine. 2026 Aug 29;99:104176. doi: 10.1016/j.eclinm.2026.104176. eCollection 2026 Sep.ABSTRACTBACKGROUND: Mineralocorticoid receptor antagonists (MRAs) are the guideline-recommended therapy for resistant hypertension. Resistant hypertension is particularly common in individuals with over

Z Zhejia Tian

The Impact of Persistent Iron Overload and Ferritin Trend on the Clinical Outcome of Peritoneal Dialysis Patients: A Retrospective Study Over 10 Years

Kidney Med. 2026 Jul 11;8(10):101463. doi: 10.1016/j.xkme.2026.101463. eCollection 2026 Oct.ABSTRACTRATIONALE & OBJECTIVE: Anemia is a major complication in chronic kidney disease. Although iron replacement therapies are commonly used, concerns about iron overload exist, for which data are limited,

V Vanessa Wing-Lam Tao

Addressing Cardiopulmonary Risk in COPD: A Multidisciplinary Expert Opinion Framework for the United States Healthcare System

Int J Chron Obstruct Pulmon Dis. 2026 Aug 31;21:596426. doi: 10.2147/COPD.S596426. eCollection 2026.ABSTRACTChronic obstructive pulmonary disease (COPD) is a prevalent and devastating condition responsible for substantial morbidity and mortality in the United States (US). Although the burden of card

S Stephen Brunton

Cellular communication network factor 1 (CCN1) associates with all-cause mortality in patients with dilated cardiomyopathy

Int J Cardiol Heart Vasc. 2026 Aug 29;66:102002. doi: 10.1016/j.ijcha.2026.102002. eCollection 2026 Oct.ABSTRACTBACKGROUND: Circulating cellular communication network factor 1 (CCN1) improves risk stratification in patients with acute coronary syndrome. We here investigated the association of CCN1 w

R Roland Klingenberg

FASN-mediated de novo lipogenesis promotes ceramide accumulation and myocardial damage in arrhythmogenic cardiomyopathy

iScience. 2026 Aug 28;29(9):117251. doi: 10.1016/j.isci.2026.117251. eCollection 2026 Sep 18.ABSTRACTArrhythmogenic cardiomyopathy (ACM) is a heritable disease caused by desmosomal gene mutations and marked by progressive myocardial loss and fibrofatty replacement. Here, we show that fatty acid synt

Z Zirui Liu

Association of Red Cell Distribution Width-Coefficient of Variation (RDW-CV) and RDW-Standard Deviation (RDW-SD) With Clinical Severity and Short-Term Outcomes in Patients With Acute Coronary Syndrome: A Prospective Observational Study

Cureus. 2026 Aug 5;18(8):e114035. doi: 10.7759/cureus.114035. eCollection 2026 Aug.ABSTRACTBACKGROUND: Acute coronary syndrome (ACS) is a major cause of cardiovascular morbidity and mortality. Red cell distribution width-coefficient of variation (RDW-CV), a routinely available complete blood count p

D Devendra Ahirwar

The Evolution of Medications for Obesity Management

JGH Open. 2026 Sep 4;10(9):e70466. doi: 10.1002/jgh3.70466. eCollection 2026 Sep.ABSTRACTThis narrative review provides an overview of progress in the development of obesity medications, including a synthesis of data describing the efficacy and safety of currently available agents and emerging thera

J Jaskirath Gill

Lived experiences of cardiovascular postoperative care in pediatric and neonatal critical care: The parents' experience

Rev Cuid. 2026 Aug 14;17(2):e5175. doi: 10.15649/cuidarte.5175. eCollection 2026 May-Aug.ABSTRACTINTRODUCTION: Heart disease in childhood is the fourth leading cause of illness and, in many cases, requires complex surgical procedures and intensive care unit care. This situation has a significant imp

S Sergio Andres Acuña-Caicedo

Construction and Validation of a Progression-Free Survival Prediction Model for Newly Diagnosed Multiple Myeloma Patients With 1q21 Gain/Amplification

Cancer Med. 2026 Sep;15(9):e72077. doi: 10.1002/cam4.72077.ABSTRACTOBJECTIVE: To investigate the clinical characteristics of newly diagnosed multiple myeloma (NDMM) patients with 1q21 gain/amplification (1q21+), construct and validate a progression-free survival (PFS) prediction model, and explore t

Y Yuexuan Rao