Remote Management of Patients With Diabetic Macular Edema Receiving Long-Term Intravitreal Anti-Vascular Endothelial Growth Factor Therapy (RE-SHINE Study): Protocol for a Real-World Study

JMIR Res Protoc. 2026 Apr 6;15:e85764. doi: 10.2196/85764.ABSTRACTBACKGROUND: Long-term intravitreal anti-vascular endothelial growth factor therapy is the gold standard for treating diabetic macular edema (DME). However, poor treatment adherence in real-world settings often leads to suboptimal visu

S Shu Li

AI-derived therapeutic development of a serotonin receptor-targeting drug for the treatment of opioid use disorder

Proc Natl Acad Sci U S A. 2026 Apr 14;123(15):e2516807123. doi: 10.1073/pnas.2516807123. Epub 2026 Apr 6.ABSTRACTThe opioid epidemic has led to a devastating loss of life nationwide. Of those dependent on opioids, many individuals desire to quit or reduce use, but their efforts are often unsuccessfu

V Valeria Lallai

Microvesicle release drives cycles of mitophagy flux disruption and inflammatory amplification in sepsis-induced myocardial dysfunction

Proc Natl Acad Sci U S A. 2026 Apr 14;123(15):e2510914123. doi: 10.1073/pnas.2510914123. Epub 2026 Apr 6.ABSTRACTSepsis-induced myocardial dysfunction strongly contributes to high mortality in patients with sepsis by exacerbating systemic organ failure; however, the onset and molecular mechanisms dr

R Rui Song

Association Between Functional Status and Cardiac Function in Chronic Heart Failure: Insights from the C-MIC II Trial

ESC Heart Fail. 2026 Apr 6:xvag102. doi: 10.1093/eschf/xvag102. Online ahead of print.ABSTRACTBACKGROUND: Relationship between changes in cardiac function, functional capacity, and patient-reported health status in heart failure (HF) remains incompletely defined, which may help inform endpoint selec

M Marat Fudim

Liver Disease in Tricuspid Regurgitation: From Congestion to Cirrhosis

No abstractEur J Heart Fail. 2026 Apr 6:xuag109. doi: 10.1093/ejhf/xuag109. Online ahead of print.NO ABSTRACTPMID:41941601 | DOI:10.1093/ejhf/xuag109

K Karl-Philipp Rommel

Is Placebo Still Ethical in Trials of Incretin Therapies?

No abstractCirculation. 2026 Apr 7;153(14):1005-1008. doi: 10.1161/CIRCULATIONAHA.125.077277. Epub 2026 Apr 6.NO ABSTRACTPMID:41941546 | DOI:10.1161/CIRCULATIONAHA.125.077277

B Brendon L Neuen

Letter by Liu and Li Regarding Article, "Ponatinib, But Not the New Abl-Kinase Inhibitor Asciminib, Activates Platelets, Leukocytes, and Endothelial Cell TNF Signaling to Induce Atherosclerotic Plaque Inflammation, Myocardial Infarction, and Stroke"

No abstractCirculation. 2026 Apr 7;153(14):e1107-e1108. doi: 10.1161/CIRCULATIONAHA.125.077133. Epub 2026 Apr 6.NO ABSTRACTPMID:41941543 | DOI:10.1161/CIRCULATIONAHA.125.077133

C Chao Liu

Advanced microfluidic and 3D cell culture platforms for modeling vascularization in diabetic foot ulcers: A systematic review of translational challenges and perspectives

PLoS One. 2026 Apr 6;21(4):e0328278. doi: 10.1371/journal.pone.0328278. eCollection 2026.ABSTRACTThe healing process of diabetic foot ulcers (DFUs) presents a slow pattern with an increased risk of infections, ischemia, and thrombosis correlated with high levels of reactive oxygen species production

A Ana Karoline Almeida da Silva

Association between allostatic load and thyroid function in U.S. adults: a cross-sectional study based on NHANES data

Stress. 2026 Dec 31;29(1):2653858. doi: 10.1080/10253890.2026.2653858. Epub 2026 Apr 6.ABSTRACTChronic stress may contribute to endocrine dysregulation. The allostatic load (AL), an indicator of cumulative physiological burden across multiple systems, has unclear associations with thyroid function.

D Dai Zhuolin

A Hypoxia-reoxygenation Injury Model in Self-assembling Human Cardioids

J Vis Exp. 2026 Mar 17;(229). doi: 10.3791/70310.ABSTRACTWithout rapid revascularization, ischemic heart disease leads to irreversible loss of cardiomyocytes, scar formation, and decreased cardiac function. The ability to model hypoxia-reoxygenation injuries and evaluate potential therapeutic interv

L Lauren E Parker

Clinical profile and hospital outcomes of children with Down syndrome diagnosed with congenital heart disease in a developing country: A retrospective study

PLoS One. 2026 Apr 6;21(4):e0345457. doi: 10.1371/journal.pone.0345457. eCollection 2026.ABSTRACTBACKGROUND: The World health organization (WHO) identifies Down syndrome (DS) as one among common congenital disorders, along with congenital heart defects. Approximately fifty percent of children diagno

Z Zawadi Edward Kalezi

Dynamic thresholding and robust contrastive techniques for enhanced semi-supervised cardiac segmentation

PLoS One. 2026 Apr 6;21(4):e0342567. doi: 10.1371/journal.pone.0342567. eCollection 2026.ABSTRACTCardiac segmentation plays a crucial role in the diagnosis of cardiovascular diseases. However, the manual annotation of cardiac structures is a labor-intensive and time-consuming task that requires high

Y Yafei Mi

Polygenic Risk Scores disclosure for cardiovascular prevention: Protocol of the Personalized HeartCare (PHC) trial

PLoS One. 2026 Apr 6;21(4):e0345294. doi: 10.1371/journal.pone.0345294. eCollection 2026.ABSTRACTBACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of death and morbidity in Europe, highlighting the need for innovative and personalized prevention strategies. Communicating genetic risk

L Luigi Russo

Changes in the use of vitamin K antagonists and direct oral anticoagulants and impact on the incidence of oral anticoagulation-related intracerebral hemorrhage: population-wide prescription patterns in two 5-year cohorts

Ann Med. 2026 Dec;58(1):2652115. doi: 10.1080/07853890.2026.2652115. Epub 2026 Apr 6.ABSTRACTBACKGROUND: We investigated population-wide changes in prescriptions of oral anticoagulants (OAC) (vitamin K antagonists [VKA]) compared to direct oral anticoagulants (DOAC) and whether these translated into

L Liisa Tomppo

Cancer-Associated Takotsubo Syndrome: An Emerging Intersection of Cardio-Oncology

Cardiol Rev. 2026 Apr 6. doi: 10.1097/CRD.0000000000001269. Online ahead of print.ABSTRACTTakotsubo syndrome (TTS) is an acute stress-induced cardiomyopathy that mimics acute coronary syndrome and is recognized in patients with malignancy. Outcomes analyses and contemporary cardio-oncology reviews f

J Jatin Thukral

A multi-modal data fusion and real-time monitoring on stroke risk prediction using federated learning

PLoS One. 2026 Apr 6;21(4):e0330244. doi: 10.1371/journal.pone.0330244. eCollection 2026.ABSTRACTPredicting the risk of stroke is one of the critical problems in healthcare, which necessitates efficient solutions for providing accurate and prompt risk assessments while preserving data confidentialit

R Ramya Sree K

Physical frailty, genetic risk, mediating biomarkers, and risk of suicide attempt: A prospective cohort study

PLoS Med. 2026 Apr 6;23(4):e1005045. doi: 10.1371/journal.pmed.1005045. Online ahead of print.ABSTRACTBACKGROUND: While physical frailty is linked to psychiatric disorders, its association with suicide attempt (SA) risk is unclear. We aimed to investigate the prospective association of physical frai

W Wei Hu

Expression of Concern: Mortality trends and disparities for coexisting chronic obstructive pulmonary disease and cardiovascular disease: A retrospective analysis of deaths in the United States from 1999-2020

No abstractPLoS One. 2026 Apr 6;21(4):e0346410. doi: 10.1371/journal.pone.0346410. eCollection 2026.NO ABSTRACTPMID:41941414 | DOI:10.1371/journal.pone.0346410

P PLOS One Editors

A Standardized Murine Model with a Three-Person Workflow for Studying Acute Cellular and Antibody-Mediated Rejection in Xenotransplantation

J Vis Exp. 2026 Mar 20;(229). doi: 10.3791/68756.ABSTRACTDespite recent advancements in xenotransplantation, acute rejection remains a major barrier to its clinical application. Acute cellular rejection (ACR) and acute antibody-mediated rejection (AMR) are the primary immune responses leading to ear

X Xiaofei Zhu

Ventricular Tachycardia as the Initial Presentation of Tuberculous Myocarditis

JACC Case Rep. 2026 Apr 6:107613. doi: 10.1016/j.jaccas.2026.107613. Online ahead of print.ABSTRACTBACKGROUND: Myocardial involvement in tuberculosis is exceptionally rare and may closely mimic cardiac sarcoidosis, particularly when presenting with ventricular arrhythmias.CASE SUMMARY: A 47-year-old

A Arnau Subira-Ingla

Sharper Images, Clearer Physiology?: What Photon-Counting CT Adds to CT-FFR

No abstractJACC Cardiovasc Imaging. 2026 Apr 2:S1936-878X(26)00143-9. doi: 10.1016/j.jcmg.2026.03.003. Online ahead of print.NO ABSTRACTPMID:41941354 | DOI:10.1016/j.jcmg.2026.03.003

B Bjarne Linde Nørgaard

Selective and Permanent Occlusion of the Middle Cerebral Artery in Rats: An Experimental Approach for Studying Motor and Spatial Memory Deficits

J Vis Exp. 2026 Mar 20;(229). doi: 10.3791/70519.ABSTRACTWith major clinical relevance, ischemic stroke (IS) demands experimental approaches that enable the development of novel adjuvant therapies. Due to the similarity of the cerebral vascular anatomy to humans, rats are widely used as experimental

L Leandro Pelegrini de Almeida

Dietary Fiber in the Prevention and Management of Obesity, Diabetes, and Cardiovascular Disease: A Mini Review

Curr Cardiol Rev. 2026 Mar 27. doi: 10.2174/011573403X437559251128090907. Online ahead of print.ABSTRACTINTRODUCTION: Dietary fiber is a critical modulator of metabolic pathways underlying obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD).METHODS: Literature published betwee

D Dharmendra Kumar

Inflammatory Biomarkers in Coronary Artery Disease: Diagnostic and Prognostic Potential?

Curr Cardiol Rev. 2026 Mar 17. doi: 10.2174/011573403X457005260226155043. Online ahead of print.ABSTRACTINTRODUCTION: Coronary artery disease (CAD) is a leading global cause of morbidity and mortality. Advances in treatment have resulted in a new, growing cohort of patients who require lifelong mana

R Rahul Ghelani