Landmark Clinical Trials Shaping Contemporary Guideline-Directed Medical Therapy for Heart Failure
No abstractESC Heart Fail. 2026 May 22:xvag141. doi: 10.1093/eschf/xvag141. Online ahead of print.NO ABSTRACTPMID:42172672 | DOI:10.1093/eschf/xvag141
Intravenous immunoglobulin administration may obscure the detection of small monoclonal proteins in patients with multiple myeloma
Am J Clin Pathol. 2026 May 5;165(5):aqag050. doi: 10.1093/ajcp/aqag050.ABSTRACTOBJECTIVES: Patients with multiple myeloma (MM) undergoing treatment increasingly receive intravenous immunoglobulin (IVIG) therapy for hypogammaglobulinemia and immunosuppression. Here we sought to investigate whether IV
Cardiac Arrest Survivors' Perspectives to Inform the Co-Design of a Web-Based Support and Learning Platform: Qualitative Content Analysis
J Med Internet Res. 2026 May 22;28:e84432. doi: 10.2196/84432.ABSTRACTBACKGROUND: Survivors of cardiac arrest often face multifaceted challenges-cognitive, emotional, physical, and existential-that extend beyond clinical recovery. Despite these long-term consequences, follow-up care is often insuffi
Protocol for Monitoring Postpartum Hypertension Outcomes via a Smartphone App (MOMitor): Ecological Momentary Assessment
JMIR Res Protoc. 2026 May 22;15:e91392. doi: 10.2196/91392.ABSTRACTBACKGROUND: Postpartum hypertension defined as elevated blood pressure after childbirth, affects approximately 20% of women after delivery. Digital health interventions that include remote monitoring therefore, present an important o
Effect of a Personalized Mobile Health Intervention Using Artificial Intelligence (the WARIFA App) Versus a Nonpersonalized Intervention on User-Defined Objectives, Healthy Lifestyles, and Management of Type 1 Diabetes (T1D): Protocol for a Randomized Controlled Trial
JMIR Res Protoc. 2026 May 22;15:e84510. doi: 10.2196/84510.ABSTRACTBACKGROUND: Noncommunicable diseases are the leading cause of death worldwide. Cardiovascular and respiratory diseases, cancer, and type 2 diabetes share common risk factors that can be addressed: physical activity, a healthy diet, a
The clinical utility of telangiectasia quantification as markers of vascular disease progression in systemic sclerosis
Rheumatology (Oxford). 2026 May 22:keag267. doi: 10.1093/rheumatology/keag267. Online ahead of print.ABSTRACTOBJECTIVES: Telangiectasia are common in systemic sclerosis (SSc). We explored the relationship between the site and quantity of telangiectasia with disease characteristics in SSc and the agr
Evaluating the impact of positional changes on pain in stroke patients unable to communicate verbally in the intensive care unit
Agri. 2026 Apr 29;38(2):96-110. doi: 10.5606/agri.2026.49.ABSTRACTBACKGROUND: This study aims to determine the effect of position changes on pain in stroke patients who are unable to communicate verbally in the intensive care unit (ICU).PATIENTS AND METHODS: Between August 2021 and February 2022, a
Estimated Glomerular Filtration Rate Discordance and Cardiopulmonary Morbidity in Sickle Cell Disease
Blood Adv. 2026 May 22:bloodadvances.2026020218. doi: 10.1182/bloodadvances.2026020218. Online ahead of print.ABSTRACTDiscordance between cystatin C- and creatinine-based estimated glomerular filtration rate (eGFR) is a recognized cardiovascular risk marker, yet its magnitude and clinical significan
Carotid-femoral pulse wave velocity and strain echocardiography in neonates: impact of maternal diabetes and hypertension
Turk J Pediatr. 2026 Mar 26;68(2):221-234. doi: 10.24953/turkjpediatr.2026.7901.ABSTRACTBACKGROUND: The arterial wall tends to stiffen owing to prolonged exposure to cardiovascular disease risk factors such as high blood pressure, hyperglycemia, and chronic inflammation. Epidemiological research has
Aortic Segments-Depending Hypertensive Remodeling Is Driven by Mitochondrial Fusion Dysfunction
FASEB J. 2026 May 31;40(10):e71937. doi: 10.1096/fj.202503667R.ABSTRACTOPA1 haploinsufficiency exacerbates severe hypertension-induced aortic remodeling in a segment-specific manner, revealing differential vulnerability between the suprarenal abdominal aorta (SRAA) and the descending thoracic aorta
Bioactive factors in Endometriosis Peritoneal Fluid Remodel Human Cardiomyocytes
Am J Physiol Heart Circ Physiol. 2026 May 22. doi: 10.1152/ajpheart.00259.2026. Online ahead of print.ABSTRACTEndometriosis is associated with increased cardiovascular disease (CVD) risk, yet the cellular basis for this relationship remains unclear. We examined whether peritoneal fluid (PF) from wom
Lateral Circumflex Femoral Artery Pseudoaneurysm Post-Hip Arthroscopy and Periacetabular Osteotomy in Ehlers-Danlos Syndrome: A Case Report
JBJS Case Connect. 2026 May 22;16(2). doi: 10.2106/JBJS.CC.25.00598. eCollection 2026 Apr 1.ABSTRACTCASE: An 18-year-old woman with Ehlers-Danlos syndrome developed subacute thigh pain on postoperative day 21 following elective hip arthroscopy and a periacetabular osteotomy. Doppler ultrasound revea
On-demand formation of ultrathin liquid metal hydrogel tattoos for conformal and low-impedance bioelectronics
Sci Adv. 2026 May 22;12(21):eaee2233. doi: 10.1126/sciadv.aee2233. Epub 2026 May 22.ABSTRACTUltrathin conductive hydrogels provide conformal and stable contact for flexible bioelectronics, which is critical for achieving the low impedance necessary for high-quality electrophysiological signal acquis
Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis
Sci Adv. 2026 May 22;12(21):eaeh0301. doi: 10.1126/sciadv.aeh0301. Epub 2026 May 22.ABSTRACTAmyloid precursor protein (APP) gives rise to amyloid-β, a pathological factor in Alzheimer's disease. However, the physiological role of APP and its homolog amyloid precursor-like protein 2 (APLP2), which ar
Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants
Sci Adv. 2026 May 22;12(21):eaea9389. doi: 10.1126/sciadv.aea9389. Epub 2026 May 22.ABSTRACTThe protein tyrosine phosphatase SHP2, encoded by PTPN11, is an important regulator of Ras/mitogen-activated protein kinase signaling that acts downstream of receptor tyrosine kinases and other transmembrane
Association between different atherogenic and insulin resistance indices and infertility in polycystic ovary syndrome patients
PLoS One. 2026 May 22;21(5):e0343783. doi: 10.1371/journal.pone.0343783. eCollection 2026.ABSTRACTBACKGROUND: This study aimed to assess the association between multiple atherogenic and insulin resistance indices-including TyG, TyG-BMI, AIP, TG-HDL, and METS-IR-and infertility in women with PCOS, an
Restrictive versus liberal oxygenation targets in patients with acute heart failure and pulmonary congestion-A protocol for a Randomized Controlled Trial (The REDOX-AHF trial)
PLoS One. 2026 May 22;21(5):e0349791. doi: 10.1371/journal.pone.0349791. eCollection 2026.ABSTRACTINTRODUCTION: Acute heart failure (AHF) is the cause of one in twenty hospital admissions. Supplemental oxygen therapy is a routine treatment in the management of patients with dyspnea, including those
Reconstructing 12-lead ECG from 3-lead ECG using variational autoencoder to improve cardiac disease detection of wearable ECG devices
PLOS Digit Health. 2026 May 22;5(5):e0001335. doi: 10.1371/journal.pdig.0001335. eCollection 2026 May.ABSTRACTTwelve-lead electrocardiograms (ECGs) are the clinical gold standard for cardiac diagnosis, offering comprehensive spatial coverage of the heart necessary for detecting conditions such as my
Exploratory research on drugs after lung surgery based on real-world data from the FDA adverse event reporting system database
PLoS One. 2026 May 22;21(5):e0346792. doi: 10.1371/journal.pone.0346792. eCollection 2026.ABSTRACTBACKGROUNDS: Lung surgery is the most common surgery in thoracic surgery, but postoperative dyspnea, cough, palpitations, and chest pain seriously affect the quality of life of patients and hinder their
Paroxysmal atrial fibrillation-like bursts in racehorses: do they affect speed and performance? A case control study
J Vet Intern Med. 2026 May 4;40(3):aalag095. doi: 10.1093/jvimsj/aalag095.ABSTRACTBACKGROUND: Paroxysmal atrial fibrillation (pAF) occurs sporadically in horses and has been implicated in poor performance. Diagnosis in large numbers of horses has previously relied on post-exercise ECGs.HYPOTHESIS/OB
Speech therapy intervention in a patient with multiple myeloma and dysphagia - a case study from clinical practice
Klin Onkol. 2026;39(1):64-67. doi: 10.48095/ccko202664.ABSTRACTBACKGROUND: Swallowing disorders (dysphagia) in patients with multiple myeloma (MM) occur less frequently than in neurological or structural diagnoses; however, they can significantly affect nutrition, quality of life, and overall progno
Changes in hemostasis and other disorders caused by monoclonal immunoglobulin and/or free light chains
Klin Onkol. 2026;39(1):31-39. doi: 10.48095/ccko202631.ABSTRACTBACKGROUND: Monoclonal immunoglobulin and/or free light chains cause diverse complications that can affect almost all tissues or organs.AIM: Monoclonal immunoglobulin can interfere with hemostasis and cause both hypercoagulation or hemor
New causal discovery algorithm over censored variables identifies subtype-specific drivers of breast cancer progression
Gigascience. 2026 May 22:giag060. doi: 10.1093/gigascience/giag060. Online ahead of print.ABSTRACTMany research domains are producing large, multi-scale, multi-modal datasets at growing rates with mixed variable types (continuous, discrete, censored). Identifying possible cause-effect associations i
Augmented Reality-Guided Decision Support in Simulated Pediatric Cardiac Arrest: A Randomized Clinical Trial
JAMA Netw Open. 2026 May 1;9(5):e2614030. doi: 10.1001/jamanetworkopen.2026.14030.ABSTRACTIMPORTANCE: Guideline-adherent management of pediatric in-hospital cardiac arrest (IHCA) remains challenging, and deviations from best practices are common. Augmented-reality (AR)-enabled, role-specific decisio