Angiogenic T cells and cognitive function in older adults with type 2 diabetes treated with GLP-1 receptor agonists

Aging Clin Exp Res. 2026 May 24. doi: 10.1007/s40520-026-03417-0. Online ahead of print.ABSTRACTBACKGROUND: Older adults with type 2 diabetes mellitus (T2DM) are at high risk of both cardiovascular complications and cognitive decline, with major implications for independence and self-management. End

M Miriam Longo

Systemic immune-inflammation index predicts left atrial thrombus in non-valvular atrial fibrillation: A retrospective study of 847 patients

J Thromb Thrombolysis. 2026 May 24. doi: 10.1007/s11239-026-03323-2. Online ahead of print.ABSTRACTNon-valvular atrial fibrillation (NVAF) serves as a primary cause of cardioembolic stroke, with left atrial thrombus (LAT) functioning as its major thrombotic substrate. The systemic immune-inflammatio

Y Yu Wang

Temporal Trends and Future Projections of P ulmonary Embolism and Top Contributing Causes of death in the United States, 1968-2040: insights from the CDC WONDER database

J Thromb Thrombolysis. 2026 May 24. doi: 10.1007/s11239-026-03281-9. Online ahead of print.ABSTRACTPulmonary embolism (PE) is a preventable yet often deadly cardiovascular event. We aimed to investigate PE mortality trends from 1968-2023 and forecast rates through 2040 in the U.S. We analyzed CDC WO

S Saifullah Khan

Direct oral anticoagulants versus vitamin K antagonists for atrial fibrillation patients on dialysis: A systematic review and meta-analysis of randomized controlled trials and real-world evidence

J Thromb Thrombolysis. 2026 May 24. doi: 10.1007/s11239-026-03322-3. Online ahead of print.ABSTRACTAtrial fibrillation (AF) is the most common arrhythmia in end-stage renal disease (ESRD) patients on dialysis. These patients face high risks of both thromboembolism and bleeding. Pivotal randomized co

O Omar Shaheen

Two decades of pulmonary vascular disease and ischemic heart disease mortality in the united states: A longitudinal analysis using CDC WONDER (1999-2020)

J Thromb Thrombolysis. 2026 May 24. doi: 10.1007/s11239-026-03329-w. Online ahead of print.ABSTRACTPulmonary vascular disease (PVD) and ischemic heart disease (IHD) are major contributors to cardiovascular mortality in U.S. adults. This retrospective study aims to examine mortality trends and demogr

A Areesha Nawaz

NOTCH3 signal activation by its extracellular domain accumulation in an iPSC line newly established from a CADASIL patient

Hum Cell. 2026 May 24;39(6):77. doi: 10.1007/s13577-026-01391-3.ABSTRACTCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small-vessel disease caused by NOTCH3 mutations, yet its pathogenic mechanisms remain inc

R Ruihua Sun

Validation of the Obesity Lifecycle Model Built to Assess the Cost Effectiveness of Novel Therapies in the Management of Obesity

Pharmacoecon Open. 2026 May 24. doi: 10.1007/s41669-026-00661-y. Online ahead of print.ABSTRACTBACKGROUND: Economic models support healthcare decision makers to efficiently assess value and allocate resources; formal validation is critical to ensure confidence in model outputs. The Obesity Lifecycle

B Ben Modley

The role of pullback pressure gradient in guiding coronary artery disease management

Future Cardiol. 2026 May 24:1-5. doi: 10.1080/14796678.2026.2654616. Online ahead of print.ABSTRACTCoronary artery disease (CAD) remains the leading cause of death worldwide. Integrating coronary physiology into treatment decision-making is essential to optimize outcomes. Fractional flow reserve (FF

K Kazumasa Ikeda

Renal denervation in experimental autoimmune myocarditis: association with cardiac function and changes in calcium and MAPK/ERK signaling

Basic Res Cardiol. 2026 May 24. doi: 10.1007/s00395-026-01183-8. Online ahead of print.ABSTRACTRenal denervation (RDN) has emerged as a potential therapeutic strategy to modulate autonomic imbalance and attenuate inflammation in cardiovascular disease. However, the mechanisms underlying its cardiopr

Y Ya-Wen Hsiao

Evidence for Decreasing the Age of Atrial Fibrillation Screening for Indigenous People in Australia: A Systematic Review With Meta-Analysis

Med J Aust. 2026 May;224(5):e70208. doi: 10.5694/mja2.70208.ABSTRACTOBJECTIVE: To determine whether the screening age for atrial fibrillation (AF) should be lowered for Indigenous Australians with the goal of reducing risk of stroke and other health burdens.STUDY DESIGN: Systematic review of medical

V Vita Christie

Lipoprotein(a) and residual cardiovascular risks in Japanese patients with coronary artery disease who achieve guideline-recommended low-density lipoprotein cholesterol goals

Eur Heart J. 2026 May 24:ehag446. doi: 10.1093/eurheartj/ehag446. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Current guidance recommends better low-density lipoprotein cholesterol (LDL-C) control in patients with elevated lipoprotein(a) [Lp(a)] as Lp(a) lowering therapies are unavailable. Wh

Y Yu Kataoka

Real-World Safety and Retention of Tofacitinib in Elderly Versus Non-elderly Patients With Rheumatoid Arthritis: A Retrospective Cohort Study in Taiwan

Int J Rheum Dis. 2026 May;29(5):e70683. doi: 10.1111/1756-185x.70683.ABSTRACTOBJECTIVES: Tofacitinib, the first approved oral small-molecule Janus kinase inhibitor (JAKi), is widely used for treating rheumatoid arthritis (RA). This study aims to compare the drug retention rates of tofacitinib betwee

L Li-Huei Chiang

Evaluation of the effect of baseline predictors on the incidence of metabolic syndrome in middle-aged and elderly individuals: a population-based cohort study in Southwest Iran

Diabetol Metab Syndr. 2026 May 23. doi: 10.1186/s13098-026-02190-4. Online ahead of print.ABSTRACTBACKGROUND: Metabolic syndrome (MetS) is a key predictor of non-communicable diseases (NCDs) and mortality, causing public health challenge worldwide. This study aimed to estimate the incidence rates an

S Seyedeh Maryam Hashemi

Why promising ATMPs fail to reach patients: a qualitative stakeholder-informed analysis of cell therapy access in Europe

J Transl Med. 2026 May 23. doi: 10.1186/s12967-026-08303-x. Online ahead of print.ABSTRACTBACKGROUND: Advanced therapy medicinal products (ATMPs) comprise gene therapies, somatic cell therapies, tissue engineered products (TEPs), and combined ATMPs. These modalities have the potential to deliver dur

G Giuseppe Di Mauro

Interactive effects of green-space exposure and air pollution on cardiovascular disease risk: a study based on the CHARLS and CLHLS databases

BMC Public Health. 2026 May 23. doi: 10.1186/s12889-026-27850-y. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular diseases are common in aging populations and are closely associated with multiple factors. However, the cumulative effects of green-space exposure and air pollutants on cardiovas

X Xiaolong Chuai

Enhancing cardiovascular disease risk communication in diabetes care using Kern's six-step model: development and pilot of a training program for general practitioners

BMC Prim Care. 2026 May 23. doi: 10.1186/s12875-026-03392-5. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular diseases (CVDs) caused by diabetes pose a significant health burden. CVD risk communication refers to the process of conveying CVD risk information to the public or patients at the i

P Panpan Feng

Continuous serratus-intercostal plane block versus intercostal cryoanalgesia for postoperative pain after minimally invasive cardiac surgery: a prospective comparative observational study

BMC Anesthesiol. 2026 May 23. doi: 10.1186/s12871-026-03936-3. Online ahead of print.ABSTRACTBACKGROUND: Minimally invasive cardiac surgery via minithoracotomy is associated with postoperative pain. Continuous BRILMA (block of the lateral branches of the intercostal nerves in the mid-axillary line)

S Susana González-Suárez

Aminoglycosides induce immune activation but is insufficient for systemic viral control: a double-blind randomized-controlled clinical trial

Commun Med (Lond). 2026 May 23. doi: 10.1038/s43856-026-01678-4. Online ahead of print.ABSTRACTBACKGROUND: Mucosally-applied aminoglycosides have demonstrated host-directed antiviral activity in preclinical models through induction of interferon-stimulated genes (ISGs). However, it remains unknown i

P Punitha Sivanandam

Temporal trends in device selection and clinical outcomes after femoropopliteal endovascular therapy: a multicenter real-world study

Cardiovasc Interv Ther. 2026 May 23. doi: 10.1007/s12928-026-01291-1. Online ahead of print.ABSTRACTDrug-coated balloons (DCBs) are increasingly used in femoropopliteal (FP) endovascular therapy (EVT) to limit permanent scaffold implantation. Although this paradigm shift has substantially altered tr

S Shinsuke Mori

Association between METS-VF and hypertension in U.S.: a cross-sectional analysis of NHANES data

Sci Rep. 2026 May 23. doi: 10.1038/s41598-026-54530-z. Online ahead of print.ABSTRACTVisceral fat accumulation is a key factor in the onset of cardiometabolic diseases, including hypertension. Metabolic Score for Visceral Fat (METS-VF) is an innovative, non-invasive metric developed to estimate visc

Z Zhen Guo

Carbapenem-resistant Gram-negative bacilli infections in Japanese patients with cancer

Sci Rep. 2026 May 23. doi: 10.1038/s41598-026-54591-0. Online ahead of print.ABSTRACTCarbapenem-resistant bacteria represent a significant challenge for patients with cancer; however, the characteristics and prognoses of carbapenem-resistant Gram-negative bacilli (CRGNB) infections in Japanese patie

N Naoya Itoh

RBM20 isoform regulation by independent transcription start sites adapts alternative splicing in development and disease

Nat Commun. 2026 May 23;17(1):4607. doi: 10.1038/s41467-026-73230-w.ABSTRACTRBM20 is a cardiac splicing regulator whose dysfunction causes severe cardiomyopathies. Here, we uncover an unexpected layer of RBM20 regulation through a previously unrecognized transcription start site located between the

M Michael H Radke

Multi-region proteomic mapping identifies FTL1 and SERPINA3K as protective factors in cardiac aging

Cell Death Dis. 2026 May 23. doi: 10.1038/s41419-026-08882-z. Online ahead of print.ABSTRACTAging is a well-recognized risk factor in cardiovascular diseases (CVDs), primarily due to its association with the gradual decline in cardiac function. This decline significantly influences the pathogenesis

J Jingnan Huang

Ferroptosis and macrophage polarization: mechanisms, interplay, and implications for medical applications

Cell Death Discov. 2026 May 23. doi: 10.1038/s41420-026-03147-2. Online ahead of print.ABSTRACTFerroptosis, a unique form of regulated cell death driven by iron-dependent lipid peroxidation, and macrophage polarization, which reflects the high plasticity of the immune system, represent two prominent

Y Yajuan Zhao