Cardio-Kidney-Metabolic Therapy Use Among Adults With Type 1 Diabetes and Chronic Kidney Disease

Diabetes Obes Metab. 2026 Mar 12. doi: 10.1111/dom.70640. Online ahead of print.ABSTRACTAIMS: Kidney and cardiovascular diseases are highly prevalent among patients with Type 1 diabetes. To date, no randomised clinical trial has reported on the impact of novel cardio-kidney-metabolic (CKM) therapies

M M Luiza Caramori

Neoadjuvant immune checkpoint inhibitors for muscle-invasive urothelial carcinoma: a systematic review and meta-analysis

Immunotherapy. 2026 Mar 12:1-17. doi: 10.1080/1750743X.2026.2643128. Online ahead of print.ABSTRACTINTRODUCTION: Muscle-invasive urothelial carcinoma (MIUC) represents one-quarter of cancers and carries morbidity and mortality. Although cisplatin neoadjuvant chemotherapy plus radical cystectomy impr

A Ana Luíza Rocha Soares Menegat

Incretin and Glucagon Signalling in MASLD and MASH: Integrating Metabolic Pathways With Disease Progression

Diabetes Obes Metab. 2026 Mar 12. doi: 10.1111/dom.70624. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) arises from dysregulated interactions between nutrient delivery, adipose tissue lipid handling and liver lipid metabolism, which collectively coale

E Evangelia E Tsakiridis

Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio combination for acute coronary syndrome risk stratification: A retrospective observational study from a Metropolitan Medical Center in Taiwan

Sci Prog. 2026 Jan-Mar;109(1):368504261433395. doi: 10.1177/00368504261433395. Epub 2026 Mar 12.ABSTRACTObjectiveTo evaluate the prognostic value of the combined neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) for adverse outcomes in Taiwanese patients with acute coronary

Y Yu-Cheng Chen

m6AHD: a new framework for identifying abnormal N6-methyladenosine (m6A) in heart diseases based on sequencing features

Front Genet. 2026 Feb 25;17:1776616. doi: 10.3389/fgene.2026.1776616. eCollection 2026.ABSTRACTINTRODUCTION: Cardiovascular disease (CVD) is a major threat to health, with high incidence rates and a trend toward younger age groups. RNA modifications are an important component of epigenetics, widely

J Jiajie Lu

Unravelling the genetic architecture of cardiovascular disease through structural variant detection with whole-genome sequencing

Front Genet. 2026 Feb 25;17:1747711. doi: 10.3389/fgene.2026.1747711. eCollection 2026.ABSTRACTCardiovascular disease (CVD) remains the leading cause of worldwide morbidity and mortality. Studies have found that there is a significant genetic component contributing to CVD development. Advances in ge

D Dona N P Colombage

Prescribed Medication Burden by Tobacco Smoking and E-Cigarette Use Status

Health Sci Rep. 2026 Mar 9;9(3):e72072. doi: 10.1002/hsr2.72072. eCollection 2026 Mar.ABSTRACTPURPOSE: Tobacco smoking is a major driver of chronic disease, and e-cigarette use is increasingly common, yet their associations with prescribed medication burden remain unclear.METHODS: We analysed data f

Y Yusuff Adebayo Adebisi

Acceptability of Cardiovascular Disease Point-of-Care Diagnostics in Primary Care Settings: A Scoping Review

Health Sci Rep. 2026 Mar 9;9(3):e72032. doi: 10.1002/hsr2.72032. eCollection 2026 Mar.ABSTRACTBACKGROUND AND AIMS: Cardiovascular disease (CVD) remains the leading global cause of death, with 80% of deaths occurring in low- and middle-income countries (LMICs). Improving access to screening and early

N Nakedi Moswete

Ageing with Haemophilia: Comorbidities in Focus

Transfus Med Hemother. 2026 Jan 30. doi: 10.1159/000550750. Online ahead of print.ABSTRACTBACKGROUND: Life expectancy in people with haemophilia (PWH) has risen markedly, creating an ageing population with both age-related diseases and sequelae of historical treatment eras. Chronic hepatitis C virus

H Heiko Rühl

Initial single-center experience with robot-assisted single-port major pulmonary resection: a retrospective study

J Thorac Dis. 2026 Feb 28;18(2):95. doi: 10.21037/jtd-2025-2008. Epub 2026 Feb 12.ABSTRACTBACKGROUND: The da Vinci Single-Port (SP) system is a robotic platform designed to facilitate uniportal surgery. This study aimed to evaluate the feasibility and safety of the da Vinci SP system for major pulmo

I In Ha Kim

Development and internal validation of a computed tomography angiography‑based prediction model for acute rupture in type A aortic dissection

J Thorac Dis. 2026 Feb 28;18(2):88. doi: 10.21037/jtd-2025-2015. Epub 2026 Feb 6.ABSTRACTBACKGROUND: While emergency surgery for acute type A aortic dissection (TAAD) is lifesaving, real-world delays occur. Current risk stratification lacks objective imaging criteria. We aimed to develop a computed

J Jiazhen Mei

Pericoronary fat attenuation index predicts vulnerable plaque and adverse outcomes in coronary heart disease

J Thorac Dis. 2026 Feb 28;18(2):153. doi: 10.21037/jtd-2025-775. Epub 2026 Feb 26.ABSTRACTBACKGROUND: Noncalcified coronary plaque is prone to rupture and may lead to major adverse cardiovascular events (MACEs). The pericoronary fat attenuation index (FAI), derived from coronary computed tomographic

F Fei-Fei Luo

Perioperative high-dose selenium supplementation in open thoracic aortic surgery: a post hoc subgroup analysis of the SUSTAIN CSX trial

J Thorac Dis. 2026 Feb 28;18(2):72. doi: 10.21037/jtd-2025-1-2471. Epub 2026 Feb 12.ABSTRACTBACKGROUND: Open surgery on the thoracic aorta is associated with a variable and often pronounced postoperative inflammatory response, which contributes to organ injury and prolonged intensive care unit (ICU)

D Daniel Catena

Long-term outcomes of frozen elephant trunk for non-A non-B aortic dissection: a comparative analysis based on entry tear location

J Thorac Dis. 2026 Feb 28;18(2):94. doi: 10.21037/jtd-2025-aw-2195. Epub 2026 Feb 2.ABSTRACTBACKGROUND: Non-A non-B aortic dissection (NANB-AD) is a rare and heterogeneous subtype involving the aortic arch and descending aorta without ascending aortic involvement, and its optimal management remains

Y Yumeng Ji

Correlation of glycemic variability with the risk of atrial fibrillation and in-hospital mortality in patients diagnosed with obstructive sleep apnea: a retrospective study based on the Medical Information Mart for Intensive Care database

J Thorac Dis. 2026 Feb 28;18(2):76. doi: 10.21037/jtd-2025-1678. Epub 2026 Feb 6.ABSTRACTBACKGROUND: Obstructive sleep apnea (OSA) has seen a rising prevalence and is closely linked with various cardiovascular diseases. Fluctuations in blood sugar levels, known as glycemic variability (GV), are link

P Panxiao Li

Does the positron emission tomography-computed tomography decrease the risk of thoracoscopic lobectomy for benign disease?-a propensity score matched cohort study

J Thorac Dis. 2026 Feb 28;18(2):113. doi: 10.21037/jtd-2025-1393. Epub 2026 Feb 26.ABSTRACTBACKGROUND: Preoperative characterization of solitary pulmonary nodules is critical yet challenging, as distinguishing early-stage neoplasms from benign lesions is essential to prevent unwarranted anatomical r

D Dominika Zielińska

Amino acid infusion and renal protection in chronic kidney disease patients undergoing cardiac surgery: physiology meets clinical evidence

No abstractJ Thorac Dis. 2026 Feb 28;18(2):51. doi: 10.21037/jtd-2025-1-2543. Epub 2026 Feb 6.NO ABSTRACTPMID:41816411 | PMC:PMC12972828 | DOI:10.21037/jtd-2025-1-2543

J Jef Van den Eynde

Outcomes of lung cancer screening by low-dose computed tomography in the health screening program

J Thorac Dis. 2026 Feb 28;18(2):108. doi: 10.21037/jtd-2025-1-2450. Epub 2026 Feb 13.ABSTRACTBACKGROUND: Low-dose computed tomography (LDCT) screening reduces lung cancer mortality among high-risk smokers, but data from Southeast Asia remain limited. This study evaluated the detection yield and risk

N Niwan Klinngam

Association between monocyte-to-lymphocyte ratio and mortality in critically ill patients with acute respiratory failure: a retrospective cohort study

J Thorac Dis. 2026 Feb 28;18(2):136. doi: 10.21037/jtd-2025-1-2461. Epub 2026 Feb 26.ABSTRACTBACKGROUND: Accumulating clinical evidence suggests that the monocyte-to-lymphocyte ratio (MLR) may serve as a hematological biomarker with prognostic significance for unfavorable outcomes in cardiovascular

Z Zongyang Xiao

MiR-34a deficiency enhances nucleic acid sensing and type I IFN signaling in a mouse model of Alzheimer's disease

Front Immunol. 2026 Feb 24;17:1694824. doi: 10.3389/fimmu.2026.1694824. eCollection 2026.ABSTRACTBACKGROUND: A number of microRNAs are implicated in aging, cell senescence, inflammation, and neurodegenerative diseases. Particularly, miR-34a levels in the brain are increased in Alzheimer's disease (A

J Junling Yang

Cardiomyocyte-derived HSPB1 regulates TGF-β1 maturation and inhibits endothelial-to-mesenchymal transition in myocardial fibrosis

iScience. 2026 Feb 13;29(3):115028. doi: 10.1016/j.isci.2026.115028. eCollection 2026 Mar 20.ABSTRACTMyocardial fibrosis after myocardial infarction is promoted by endothelial-to-mesenchymal transition (EndoMT) driven by TGF-β1. We investigated whether cardiomyocyte heat shock protein B1 (HSPB1) sha

J Jia Wang

MALAT1 regulates human macrophage metabolism by interacting with HADHB

iScience. 2026 Feb 20;29(3):115107. doi: 10.1016/j.isci.2026.115107. eCollection 2026 Mar 20.ABSTRACTLong noncoding RNAs (lncRNAs) are critical regulators of immune responses and cellular metabolism. Here, we report a previously unrecognized interaction between MALAT1 and HADHB, which reveals additi

Y Yuxiang Liu

Integrated multi-omics reveals population-specific mechanisms of cardiovascular disease in high-altitude environments

iScience. 2026 Feb 20;29(3):115109. doi: 10.1016/j.isci.2026.115109. eCollection 2026 Mar 20.ABSTRACTHigh-altitude populations exhibit lower cardiovascular disease incidence and mortality with significant differences between indigenous highlanders and migrants. However, related genetic adaptation an

W Weiyu Meng

TyG and RC combined with CVD risk in CKM syndrome: A national cohort study

iScience. 2026 Feb 17;29(3):115060. doi: 10.1016/j.isci.2026.115060. eCollection 2026 Mar 20.ABSTRACTAlthough the triglyceride-glucose index (TyG, insulin resistance) and remnant cholesterol (RC, lipid metabolism) are cardiovascular disease (CVD) risk factors in cardiovascular-kidney-metabolic (CKM)

H Hongtao Lan