Mol Pharmacol. 2025 Oct 26;107(12):100085. doi: 10.1016/j.molpha.2025.100085. Online ahead of print.ABSTRACTThe atypical chemokine receptor 3 (ACKR3) has emerged as a promising drug target for the treatment of cancer, cardiovascular, and autoimmune diseases. In this study, we present the pharmacolog
J Echocardiogr. 2025 Nov 29. doi: 10.1007/s12574-025-00713-y. Online ahead of print.ABSTRACTBACKGROUND: Transvalvular flow rate (FR), defined as stroke volume divided by ejection time, is an important prognostic parameter in transcatheter aortic valve replacement (TAVR) patients. The prognostic impl
Curr Heart Fail Rep. 2025 Nov 29;22(1):43. doi: 10.1007/s11897-025-00734-9.ABSTRACTPURPOSE OF REVIEW: Current treatment strategies for heart failure primarily aim to slow disease progression. In the case of rare genetic disorders with associated cardiomyopathies, management is largely supportive. Ge
Mol Neurobiol. 2025 Nov 29;63(1):212. doi: 10.1007/s12035-025-05411-5.ABSTRACTDiabetic retinopathy (DR) is a significant complication of diabetes that results in retinal damage and the risk of blindness. Branched-chain amino acids (BCAAs) are essential amino acids that fulfill physiological roles in
Mol Neurobiol. 2025 Nov 29;63(1):215. doi: 10.1007/s12035-025-05512-1.ABSTRACTDiabetic retinopathy (DR) is a common neurovascular complication of diabetes and a leading cause of vision loss in the advanced stages. Identifying therapeutic targets to prevent early progression of DR is critical for pre
Mol Neurobiol. 2025 Nov 29;63(1):210. doi: 10.1007/s12035-025-05551-8.ABSTRACTPerinatal hypoxia causes hypoxic-ischemic brain damage (HIBD), which can result in neurological sequelae of varying severity. This syndrome is a major cause of neonatal mortality and pediatric impairment. Although research
Curr Heart Fail Rep. 2025 Nov 29;22(1):42. doi: 10.1007/s11897-025-00731-y.ABSTRACTPURPOSE OF REVIEW: Heart failure (HF) is a complex clinical syndrome of progressive cardiac dysfunction, posing a major global burden on public health. The coupling between cardiomyocyte electrophysiology and energy m
Diabetes Ther. 2025 Nov 29. doi: 10.1007/s13300-025-01826-4. Online ahead of print.ABSTRACTCardiorenal metabolic disease (CRMD) encompasses a cluster of interrelated conditions-including obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), chronic kidney disease (CKD), and metabol
Neurochem Res. 2025 Nov 29;51(1):6. doi: 10.1007/s11064-025-04622-5.ABSTRACTCerebral ischemia-reperfusion injury (CIRI) involves oxidative stress, inflammation, and regulated cell death, among which ferroptosis has emerged as a key contributor. However, therapeutic strategies targeting ferroptosis r
Mol Neurobiol. 2025 Nov 29;63(1):219. doi: 10.1007/s12035-025-05423-1.ABSTRACTOxymatrine (OMT), a major alkaloid extracted from Sophora flavescens, has been widely recognized for its anti-inflammatory and anti-cancer properties. However, its precise neuroprotective mechanisms in cerebral ischemia/re
Eur J Orthop Surg Traumatol. 2025 Nov 29;36(1):29. doi: 10.1007/s00590-025-04595-9.ABSTRACTBACKGROUND: Studies on venous thromboembolism (VTE) in patients with traumatic pelvic and acetabular fractures have shown variable epidemiology, risk factors and outcomes.METHODS: This retrospective study eval
Rheumatol Int. 2025 Nov 29;45(12):279. doi: 10.1007/s00296-025-06050-8.ABSTRACTGrowing evidence indicates that antiphospholipid antibodies (aPL) and antiphospholipid syndrome (APS) are not only associated with arterial thrombosis, but also enhanced premature atherosclerosis and stenotic lesions in v
Eur J Nucl Med Mol Imaging. 2025 Nov 29. doi: 10.1007/s00259-025-07673-6. Online ahead of print.ABSTRACTPURPOSE: Transthyretin cardiac amyloidosis (ATTR-CM) is a progressive, underdiagnosed disease with high morbidity and mortality. While disease-modifying therapies (DMTs) slow progression, early tr
Eur J Heart Fail. 2025 Nov 29. doi: 10.1002/ejhf.70071. Online ahead of print.ABSTRACTAIMS: Tafamidis reshaped the treatment paradigm in transthyretin amyloid cardiomyopathy (ATTR-CM) based on a phase-3 randomized controlled trial, but real-world data on its use remain limited. This study aimed to a
Expert Opin Investig Drugs. 2025 Nov 29. doi: 10.1080/13543784.2025.2598458. Online ahead of print.ABSTRACTINTRODUCTION: Lipoprotein(a) [Lp(a)] is an independent, inherited risk factor for atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. Lp(a) is composed of apoB-100 and apo(a). L
Int Forum Allergy Rhinol. 2025 Nov 29. doi: 10.1002/alr.70076. Online ahead of print.ABSTRACTBACKGROUND: Eosinophil peroxidase (EPX) in nasal mucus correlates with markers of type 2 inflammation and tissue eosinophilia in chronic rhinosinusitis (CRS). This study evaluated EPX as a dynamic biomarker
Congenit Anom (Kyoto). 2025 Jan-Dec;65(1):e70033. doi: 10.1002/cga.70033.ABSTRACTWe report the case of a 3-year-old girl with alpha-thalassemia/mental retardation linked to chromosome 16 (ATR-16) syndrome. The patient presented with hypotonia, developmental delay, and characteristic facial features
Ann Noninvasive Electrocardiol. 2026 Jan;31(1):e70128. doi: 10.1111/anec.70128.ABSTRACTOBJECTIVE: To compare the acute and long-term outcomes of high-power ablation for typical atrial flutter using a 4-mm irrigated catheter (4-IC) versus an 8-mm non-irrigated catheter (8-NIC).METHODS: We conducted a
Niger J Clin Pract. 2025 Nov 1;28(11):1282-1289. doi: 10.4103/njcp.njcp_82_25. Epub 2025 Nov 29.ABSTRACTBACKGROUND: Chronic subdural hematoma (CSDH) is a condition that is frequently observed in the elderly population and may lead to severe neurological outcomes.AIM: This study aims to comprehensive
Lab Med. 2025 Nov 29:lmaf084. doi: 10.1093/labmed/lmaf084. Online ahead of print.ABSTRACTINTRODUCTION: Laboratory reference ranges and phlebotomy guidelines are derived from ambulatory individuals, whose values reflect reduced plasma volume from hydrostatic pressure shifts. These conditions may not
J Am Med Inform Assoc. 2025 Nov 29:ocaf203. doi: 10.1093/jamia/ocaf203. Online ahead of print.ABSTRACTOBJECTIVES: Atrial fibrillation (AF) is common among intensive care unit (ICU) patients. Effective management of AF in this setting remains a subject of debate, with current guidelines often derived
Nutr Rev. 2025 Nov 29:nuaf231. doi: 10.1093/nutrit/nuaf231. Online ahead of print.ABSTRACTThe application of dietary quality indices (DQIs) is limited by inconsistent methods and suboptimal reporting, but the effect of index composition heterogeneity on the strength of disease associations is not cl
Kaohsiung J Med Sci. 2025 Nov 29:e70128. doi: 10.1002/kjm2.70128. Online ahead of print.ABSTRACTAcute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS-induced CMEC damage, thereby identifying a new target for ACS
Postgrad Med J. 2025 Nov 29:qgaf205. doi: 10.1093/postmj/qgaf205. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular-Kidney-Metabolic (CKM) syndrome is characterized by the interrelatedness of chronic kidney disease, cardiovascular disease, and metabolic disorders. Although physical activity i
