Actin cytoskeleton stabilization inhibits NLRP3 inflammasome activation and mitigates renal inflammation and fibrosis in obstructive nephropathy

Cell Immunol. 2025 Nov 21;420-421:105053. doi: 10.1016/j.cellimm.2025.105053. Online ahead of print.ABSTRACTObstructive nephropathy is characterized by progressive renal inflammation and tubular injury, in which the NLRP3 inflammasome plays a pivotal role. However, the contribution of cytoskeletal d

Q Qiaoli Xu

A survival analysis of T1 stage breast cancer and nomogram development: based on the SEER database

Clinics (Sao Paulo). 2025 Nov 23;80:100837. doi: 10.1016/j.clinsp.2025.100837. Online ahead of print.ABSTRACTINTRODUCTION: Breast Cancer (BC) is a widespread non-cutaneous malignancy. T1 stage of small tumors are generally considered to have a favorable prognosis, but controversy persists regarding

L Lizhi Teng

Hybrid left atrial appendage exclusion management: WATCHMAN after AtriClip

No abstractJ Invasive Cardiol. 2025 Nov 21. doi: 10.25270/jic/25.00353. Online ahead of print.NO ABSTRACTPMID:41284998 | DOI:10.25270/jic/25.00353

L Leili Pourafkari

Engagement With Text Messaging Improves Cardiovascular Medication Adherence: Secondary Analysis of a Randomized Controlled Trial

J Med Internet Res. 2025 Nov 24;27:e80794. doi: 10.2196/80794.ABSTRACTWe conducted this secondary analysis to assess whether greater engagement with a text messaging intervention was associated with improved cardiovascular medication adherence at 12 months.PMID:41284985 | DOI:10.2196/80794

R Rowan Shore-Plavec

The preclinical discovery and development of romosozumab for the treatment of people with severe osteoporosis who are at high risk of fracture

Expert Opin Drug Discov. 2025 Nov 24. doi: 10.1080/17460441.2025.2594642. Online ahead of print.ABSTRACTINTRODUCTION: . The discovery of romosozumab, a monoclonal antibody to sclerostin and treatment option for severe osteoporosis, resulted from convergent genetic research of persons with rare hyper

P Piet Geusens

Interpretable Machine Learning Models for Analyzing Determinants Affecting the Use of mHealth Apps Among Family Caregivers of Patients With Stroke in Chinese Communities: Cross-Sectional Survey Study

JMIR Mhealth Uhealth. 2025 Nov 24;13:e73903. doi: 10.2196/73903.ABSTRACTBACKGROUND: Mobile health (mHealth) apps are believed to be an effective method to support family caregivers to better care for patients with stroke. This study's purpose was to explore the status and the influencing factors of

Y Yun Du

Global & Community Health: What Did the COVID-19 Pandemic Teach Us About Neurologic Surveillance Approaches, and How Should We Be Better Prepared?

Neurology. 2025 Dec 23;105(12):e214431. doi: 10.1212/WNL.0000000000214431. Epub 2025 Nov 24.ABSTRACTIt is well recognized that many pandemic viruses are associated with neurologic complications, most recently with COVID-19. After the outbreak of the COVID-19 pandemic, neurologic surveillance platfor

R Rachael Matthews

Value of Isolated vs Multiple Malignant EEG Criteria to Reduce Prognostic Uncertainty in Comatose Patients After Cardiac Arrest

Neurology. 2025 Dec 23;105(12):e214426. doi: 10.1212/WNL.0000000000214426. Epub 2025 Nov 24.ABSTRACTBACKGROUND AND OBJECTIVES: In comatose patients after cardiac arrest (CA), only "highly malignant" or "benign" EEG patterns are recognized as robust markers of poor and good outcomes, respectively, wh

S Sarah Benghanem

Early Post-Thrombectomy MRI Markers: Temporal Evolution and Association With Reperfusion and Clinical Outcome

Neurology. 2025 Dec 23;105(12):e214418. doi: 10.1212/WNL.0000000000214418. Epub 2025 Nov 24.ABSTRACTBACKGROUND AND OBJECTIVES: A significant proportion of patients with ischemic stroke treated with endovascular therapy (EVT) do not achieve favorable clinical outcomes despite successful recanalizatio

M Marie L Luby

Strain-Insensitive Iontronic Tactile Sensor with Rigid-Soft Hybrid Architecture for Cardiovascular Assessment

ACS Sens. 2025 Nov 24. doi: 10.1021/acssensors.5c03297. Online ahead of print.ABSTRACTMechanical deformation of human skin often induces strain-pressure crosstalk and compromises signal reliability. Here, we present a strain-insensitive iontronic tactile sensor by introducing a rigid-soft hybrid arc

W Weiyan Li

Relevance of Early Vascular Aging in Clinical Routine

No abstractStroke. 2025 Dec;56(12):e377-e380. doi: 10.1161/STROKEAHA.125.051287. Epub 2025 Nov 24.NO ABSTRACTPMID:41284790 | DOI:10.1161/STROKEAHA.125.051287

S Sophia Zollner-Kiechl

Every Minute Counts: A Paradigm Shift in ICH: Perspectives and Recommendations From the Fourth Hemorrhagic Stroke Academia Industry (HEADS) Roundtable

Stroke. 2025 Dec;56(12):3563-3571. doi: 10.1161/STROKEAHA.125.052984. Epub 2025 Nov 24.ABSTRACTThe HEADS-4 (Fourth Hemorrhagic Stroke Academia Industry) roundtable discussed topics related to the importance of time in the diagnosis and treatment of intracerebral hemorrhage. The goal was to address t

H HEADS-4 Participants

Latent trajectory modeling of platelet counts and mortality risk in intensive care unit patients with atrial fibrillation

Sci Prog. 2025 Oct-Dec;108(4):368504251399568. doi: 10.1177/00368504251399568. Epub 2025 Nov 24.ABSTRACTBackgroundEarly changes in platelet count may reflect disease mechanisms affecting prognosis in critically ill patients, but their role in atrial fibrillation (AF) remains unclear.MethodsThis retr

H Huan Zuo

Association of High-Density Lipoprotein Cholesterol with the Top 10 Causes of Death

Eur J Prev Cardiol. 2025 Nov 24:zwaf749. doi: 10.1093/eurjpc/zwaf749. Online ahead of print.ABSTRACTAIM: Extremely high high-density lipoprotein cholesterol (HDL-C) may increase cardiovascular death risk, but whether such non-linear patterns extend to other major causes of death is unclear. This stu

S Shanshan Shi

Impact of LDL-C and Apolipoprotein B Level Discordance and associated Lipoprotein Particle Alterations on Cardiovascular Outcomes in a large primary prevention population

Eur J Prev Cardiol. 2025 Nov 24:zwaf750. doi: 10.1093/eurjpc/zwaf750. Online ahead of print.ABSTRACTAIMS: Emerging evidence suggests that ApoB outperforms LDL-C in predicting cardiovascular risk, especially in cases of discordance with the two. However, the specific type and composition of lipoprote

Y Yuan Du

Associations of cardiovascular health and social determinants of health with the risks of all-cause and cause-specific mortality

PLoS One. 2025 Nov 24;20(11):e0337286. doi: 10.1371/journal.pone.0337286. eCollection 2025.ABSTRACTBACKGROUND: While cardiovascular health (CVH) and social determinants of health (SDoH) are independently associated with mortality, their combined effects on mortality remain unclear. The study aimed t

B Boxuan Pu

Dogs with advanced myxomatous mitral valve disease have evidence of gastrointestinal bacterial translocation and systemic inflammation

PLoS One. 2025 Nov 24;20(11):e0337580. doi: 10.1371/journal.pone.0337580. eCollection 2025.ABSTRACTThis study aimed to explore the potential relationship between the severity of cardiovascular disease and evidence of gastrointestinal bacterial translocation with systemic and cardiac inflammation in

M Maria C Jugan

A Standardized Pig to Macaque Heterotopic Heart Xenotransplantation Model

J Vis Exp. 2025 Nov 4;(225). doi: 10.3791/68757.ABSTRACTAlthough significant progress has been made in heart xenotransplantation, challenges such as donor-recipient matching, antibody-mediated rejection, primary graft dysfunction, and postoperative thrombosis remain unresolved. Compared to orthotopi

Y Yuan Chang

Microbiota-supportive diets and hyperlipidemia: The mediating role of systemic inflammation

PLoS One. 2025 Nov 24;20(11):e0337398. doi: 10.1371/journal.pone.0337398. eCollection 2025.ABSTRACTBACKGROUND: Hyperlipidemia is a major modifiable risk factor for cardiovascular disease, and emerging evidence suggests a critical role of the gut microbiota in lipid metabolism. The Dietary Index for

W Wenjing Wang

Management of Venous Access Ports with Varying Maintenance Intervals after Chemotherapy for Malignant Tumors

J Vis Exp. 2025 Nov 4;(225). doi: 10.3791/69023.ABSTRACTTotally implantable venous access ports (TIVAPs) are essential for chemotherapy in malignant tumor patients, but catheter blockage and infection remain concerns. The standard 4-week maintenance interval increases financial and logistical burden

L Liuyan Zhang

Prediction of graft loss in living donor liver transplantation during the early postoperative period

PLoS Comput Biol. 2025 Nov 24;21(11):e1013734. doi: 10.1371/journal.pcbi.1013734. Online ahead of print.ABSTRACTLiver transplantation is almost the only way to save patients with end-stage liver disease. Particularly, living donor liver transplantation (LDLT) has gained importance in recent years th

R Raiki Yoshimura

Evidence of central autonomic dysfunction in orthostatic hypotension of Parkinson's disease

Parkinsonism Relat Disord. 2025 Dec;141:108093. doi: 10.1016/j.parkreldis.2025.108093. Epub 2025 Oct 17.ABSTRACTINTRODUCTION: Autonomic dysfunction, particularly orthostatic hypotension (OH), is common and predicts poor outcomes in Parkinson's disease (PD). Brain contributions to autonomic failure i

L Laura de Lima Xavier

Association of lithium treatment with cardiac structure and circulating leukocyte distribution in patients with bipolar disorder

J Affect Disord. 2026 Feb 1;394(Pt A):120525. doi: 10.1016/j.jad.2025.120525. Epub 2025 Oct 25.ABSTRACTBACKGROUND: Anti-inflammatory properties of lithium may have a protective effect on cardiac function in patients with bipolar disorder (BD). Complete blood count is a standard laboratory examinatio

P Pao-Huan Chen

Association between triglyceride-glucose index and depression and the mediating role of hypertension: a cross-sectional study of obese adults

J Affect Disord. 2026 Feb 1;394(Pt A):120523. doi: 10.1016/j.jad.2025.120523. Epub 2025 Oct 24.ABSTRACTBACKGROUND: Recent findings indicate a positive correlation between the TyG (triglyceride-glucose) index and the incidence of depression. However, there is a notable lack of research addressing the

Y Yifan Zhou