Thrombin dynamics and clinical events in cirrhosis: low prothrombin conversion predicts bleeding risk

Front Cell Dev Biol. 2026 Sep 1;14:1764080. doi: 10.3389/fcell.2026.1764080. eCollection 2026.ABSTRACTPro- and anti-coagulant factors are significantly altered in liver cirrhosis resulting in an increased bleeding and thrombosis risk. The thrombin generation (TG) test often seems unaltered in cirrho

R Ruth Anne Laura Willems

Clinical implementation of next-generation sequencing in tertiary health system: the Rijeka retrospective study

Front Genet. 2026 Sep 1;17:1812702. doi: 10.3389/fgene.2026.1812702. eCollection 2026.ABSTRACTOBJECTIVE: This study aimed to assess the diagnostic yield, clinical indications, and utility of next-generation sequencing (NGS) testing since its implementation through collaboration between the Universit

N Nina Pereza

Midlife BMI and A Body Shape Index in relation to mortality and coronary heart disease events in a nationwide cohort

Front Nutr. 2026 Sep 1;13:1906316. doi: 10.3389/fnut.2026.1906316. eCollection 2026.ABSTRACTBACKGROUND: Obesity is a known cardiovascular risk factor. A Body Shape Index (ABSI) is a waist circumference (WC)-based measure of abdominal obesity, independent of Body Mass Index (BMI). We examined the ind

I Itamar Shafran

Maternal environmental noise exposure during the periconceptional period and risk of congenital heart disease in offspring: a case-control study in Northwest China

Front Public Health. 2026 Sep 1;14:1923108. doi: 10.3389/fpubh.2026.1923108. eCollection 2026.ABSTRACTBACKGROUND: Environmental noise is a pervasive public health concern, yet evidence linking maternal environmental noise exposure during the periconceptional period to the risk of congenital heart di

M Mingxin Yan

Transcatheter treatment of aortic coarctation

REC Interv Cardiol. 2026 Jan 19;8(2):107-115. doi: 10.24875/RECICE.M25000557. eCollection 2026 Apr-Jun.ABSTRACTAortic coarctation is a congenital disease that consists of the narrowing of the thoracic aorta, leading to distal blood flow obstruction. Significant aortic coarctation is associated with

V Victor Arévalos

Associations of nine composite inflammatory indices with clinical outcomes after mechanical thrombectomy for acute ischemic stroke: a single-center retrospective study

Front Neurol. 2026 Sep 1;17:1874021. doi: 10.3389/fneur.2026.1874021. eCollection 2026.ABSTRACTOBJECTIVE: This study aims to explore the associations of nine common composite inflammatory indices with hemorrhagic transformation (HT), unfavorable outcome, and all-cause mortality in patients with acut

M Min Yuan

How does major bleeding influence decision-making in patients eligible for transfemoral TAVI? A single-center experience

REC Interv Cardiol. 2025 Dec 14;8(2):79-84. doi: 10.24875/RECICE.M25000548. eCollection 2026 Apr-Jun.ABSTRACTINTRODUCTION AND OBJECTIVES: To evaluate the impact of bleeding on the risk-benefit balance of coronary revascularization prior to transfemoral transcatheter aortic valve implantation (TF-TAV

C Carmen Vidau Getán

Cardiovascular risk assessment in adults with type 1 diabetes: A cross-sectional comparison of two prediction models

Biomol Biomed. 2026 Sep 14. doi: 10.17305/bb.2026.14748. Online ahead of print.ABSTRACTAccurate cardiovascular risk assessment is essential in type 1 diabetes (T1D), but agreement between disease-specific prediction models remains insufficiently characterized. This retrospective, single-center, cros

O Ognjen Milanovic

A Practical Diagnostic Approach to Patients Presenting with "Dizziness": Evaluation and Differential Diagnosis Based on the ATTEST/TiTrATE Framework

Brain Nerve. 2026 Sep;78(9):967-974. doi: 10.11477/mf.188160960780090967.ABSTRACTDizziness is one of the most common complaints encountered in outpatient clinical practice, and is associated with a wide range of underlying conditions, ranging from peripheral vestibular disorders to cerebrovascular d

I Ichiro Deguchi

Effect of phenylephrine versus ephedrine on the incidence of postoperative delirium in elderly patients undergoing non-cardiac and non-neurosurgical procedures: protocol for a multicentre, double-blind, randomized, controlled trial

Ann Med. 2026 Dec;58(1):2732555. doi: 10.1080/07853890.2026.2732555. Epub 2026 Sep 16.ABSTRACTBACKGROUND: Whether ephedrine, when used to maintain intraoperative blood pressure, is superior to phenylephrine in reducing postoperative delirium remains uncertain. This study aims to determine whether th

X Xiaoxiao Xu

Emodin Suppresses the RAGE/ROCK1 Pathway to Modulate the Oligodendrocyte Lineage and Ameliorate Demyelination in Vascular Dementia Rats

CNS Neurosci Ther. 2026 Sep;32(9):e71154. doi: 10.1002/cns.71154.ABSTRACTBACKGROUND: Vascular dementia (VD), a prevalent cognitive disorder mainly resulting from chronic cerebral hypoperfusion-triggered white matter injury (WMI), takes regulation of oligodendrocyte (OL) lineage and restoration of re

X Xueqing Wang

Melatonin Alleviates Diabetic Cardiomyopathy by Inhibiting Cellular Senescence via Activation of the MT2/SIRT1/Nrf2 Signaling Pathway

J Pineal Res. 2026 Sep;78(5):e70185. doi: 10.1111/jpi.70185.ABSTRACTDiabetic cardiomyopathy (DCM) is one of the most severe cardiovascular complications of diabetes mellitus (DM), yet effective treatment strategies remain lacking. Cellular senescence is a principal risk factor for multiple cardiovas

F Fang Liu

Trends in mortality involving co-reported arrhythmia and dyslipidemia, 1999-2023: A Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research analysis with exploratory projections to 2035

J Int Med Res. 2026 Sep;54(9):3000605261488122. doi: 10.1177/03000605261488122. Epub 2026 Sep 16.ABSTRACTObjectiveEmerging evidence links dyslipidemia to cardiac structural and electrical remodeling. This study examined national trends in mortality involving co-reported arrhythmia and dyslipidemia a

M Muhammad Huzaifa Ahmed Khan

MRP8-Cre Transgenic Mice Are Resistant to Weight Gain and Diet-Induced Obesity Independently of Neutrophils

Eur J Immunol. 2026 Sep;56(9):e70271. doi: 10.1002/eji.70271.ABSTRACTObesity is a major risk factor for metabolic syndrome, cancer, diabetes, and other diseases. The occurrence of comorbidities is associated with systemic and adipose tissue inflammation, which is marked by the presence of macrophage

S Stephan Forisch

Chronic Spontaneous Coronary Artery Dissection: A Case Report Utilizing Coronary Physiology and Optical Coherence Tomography for Diagnosis and Management

Catheter Cardiovasc Interv. 2026 Sep 15. doi: 10.1002/ccd.70888. Online ahead of print.ABSTRACTSpontaneous coronary artery dissection (SCAD) is a rare, non-atherosclerotic cause of acute coronary syndrome that disproportionately affects women without traditional cardiovascular risk factors, although

E Eduardo Silveira

Aging-Related Diseases in the U.S. Population: A Data-Driven Approach Using All of Us Electronic Health Record Data

J Gerontol A Biol Sci Med Sci. 2026 Sep 15:glag231. doi: 10.1093/gerona/glag231. Online ahead of print.ABSTRACTBACKGROUND: Aging is the strongest risk factor for most chronic diseases, yet aging-related diseases (ARDs) lack consistent, data-driven definitions. Prior work has proposed frameworks to c

B Buwei He

Late Diagnosis of Noonan Syndrome Presenting With Infective Endocarditis: A Multidisciplinary Challenge in an Underserved Population

Am J Case Rep. 2026 Sep 16;27:e952213. doi: 10.12659/AJCR.952213.ABSTRACTBACKGROUND Noonan syndrome is a clinically diagnosed genetic disorder frequently associated with congenital and structural cardiac abnormalities such as valvular dysplasia and cardiomyopathy, which may predispose patients to in

N Nur Farhanah

Oscillatory shear stress-induced endothelial extracellular vesicles exacerbate aortic valve calcification

Cardiovasc Res. 2026 Sep 16:cvag205. doi: 10.1093/cvr/cvag205. Online ahead of print.ABSTRACTAIMS: Calcific aortic valve disease (CAVD) lacks effective pharmacotherapies. Although small extracellular vesicles (sEVs) are established mediators of cellular communication, how they translate oscillatory

S Shiqi Chen

Effectiveness of Nursing and Non-Pharmacological Interventions in Reducing Intradialytic Hypotension Among Haemodialysis Patients: A Systematic Review and Meta-Analysis

Nurs Open. 2026 Sep;13(9):e70832. doi: 10.1002/nop2.70832.ABSTRACTAIM: This study aimed to systematically evaluate the effectiveness of non-pharmacological interventions in reducing intradialytic hypotension among adult patients undergoing haemodialysis and to examine their implications for nursing

M Mi-Kyoung Cho

Predictors of Resilience Among Patients Living With Heart Failure Amid Escalating Sociopolitical Challenges: A Cross-Sectional Approach

Nurs Open. 2026 Sep;13(9):e70816. doi: 10.1002/nop2.70816.ABSTRACTAIM: Exposure to chronic illness and prolonged sociopolitical adversity may shape how patients adapt to illness-related demands; however, this relationship should be interpreted cautiously because stress can both challenge and undermi

H Hiba Deek

Mechanisms of Aging in Phenylketonuria (PKU)

Am J Med Genet A. 2026 Sep 15. doi: 10.1002/ajmg.a.70301. Online ahead of print.ABSTRACTPhenylketonuria (PKU) is an autosomal recessive inherited metabolic disorder (IMD) characterized by elevated phenylalanine (Phe) levels, requiring a low-protein diet and low-Phe amino acid supplementation from bi

J John Bassett

HFpEF in perioperative medicine

Perioper Med (Lond). 2026 Sep 15;15(1):78. doi: 10.1186/s13741-026-00702-4.ABSTRACTRecent perioperative literature has increasingly questioned the central role of left ventricular ejection fraction (LVEF) in cardiovascular risk stratification. While patients with preserved LVEF may experience periop

M Maria Giulia Bellicini

Intensity-specific physical activity and mortality in 147,414 adults: a pooled accelerometer analysis

Int J Behav Nutr Phys Act. 2026 Sep 15;23(1):85. doi: 10.1186/s12966-026-01980-3.ABSTRACTBACKGROUND: Insufficient physical activity is a leading global cause of premature mortality, yet how light-, moderate-, and vigorous-intensity activity differ in their associations with mortality and the implica

M Michael J Stein

Burden of atherosclerotic cardiovascular disease attributable to high body mass index, high fasting plasma glucose or high low density lipoprotein cholesterol in young and middle-aged adults from 1990 to 2050

Diabetol Metab Syndr. 2026 Sep 12;18(1):204. doi: 10.1186/s13098-026-02236-7.ABSTRACTAIMS: This study aims to analyze the global burden of atherosclerotic cardiovascular disease (ASCVD) attributable to high low-density lipoprotein cholesterol (LDL-c), high body mass index (BMI), or high fasting plas

H Hua Zhang