Factor XIa Inhibitors for Secondary Prevention After Noncardioembolic Stroke: A Systematic Review and Meta-Analysis

Neurology. 2026 Oct 13;107(7):e218521. doi: 10.1212/WNL.0000000000218521. Epub 2026 Sep 16.ABSTRACTOBJECTIVES: Patients with noncardioembolic ischemic stroke or transient ischemic attack (TIA) remain at substantial risk of recurrent ischemic events, despite guideline-recommended antithrombotic thera

A Aristeidis H Katsanos

Redefining second-line treatment strategy, sequencing, and real-world implementation in relapsed/refractory multiple myeloma: insights from the 31st Annual Congress of the European Hematology Association

Clin Adv Hematol Oncol. 2026 Sep;24(6 Suppl 8):1-14.ABSTRACTThe management of relapsed/refractory (R/R) multiple myeloma (MM) continues to evolve with the introduction of novel therapies and the use of newer therapies in different treatment settings and combinations. Chimeric antigen receptor (CAR)

A Ajai Chari

An anesthesiological complication related to bone cement use during reconstructive osteoplasty using the Masquelet technique in a pediatric patient: A case report

Wiad Lek. 2026;79(7):1709-1714. doi: 10.36740/WLek/222248.ABSTRACTA 16-year-old male (ASA II, BMI 31) underwent reconstructive osteoplasty with insertion of a polymethylmethacrylate (PMMA) spacer. Shortly after cement application, he developed sudden hypotension, tachycardia, and decreased end-tidal

V Volodymyr Mishchuk

Minimally invasive treatment of recurrent varicose veins with thrombotic complications using EVLA: A case report

Wiad Lek. 2026;79(7):1700-1708. doi: 10.36740/WLek/218751.ABSTRACTWe present a clinical case of a 59-year-old male who complained of varicose veins and a burning sensation in the right lower limb. His medical history included bilateral great saphenous vein (GSV) removal (2003), type 2 diabetes melli

S Serhii Shchukin

Hopes and doubts about zilebesiran, a new antihypertensive drug

Wiad Lek. 2026;79(7):1646-1653. doi: 10.36740/WLek/221451.ABSTRACTThe aim of this work is to critically evaluate the benefits and risks of zilebesiran. A comprehensive literature search was conducted in PubMed and Google Scholar databases to identify relevant studies on zilebesiran and other small-i

J Jerzy Głuszek

In vivo induction of different venous thromboembolism by use of DC electrical shock on jugular vein endothelium

Wiad Lek. 2026;79(7):1549-1555. doi: 10.36740/WLek/222507.ABSTRACTOBJECTIVE: Aim: This study aimed to establish a novel rabbit model using direct electrical stimulation to induce internal jugular vein injury and subsequent organ-specific thrombosis.PATIENTS AND METHODS: Materials and Methods: Twenty

H Hanady M Moker

The molecular landscape of hypertrophic cardiomyopathy across disease stages and genotypes

Sci Transl Med. 2026 Sep 16;18(867):eaea2747. doi: 10.1126/scitranslmed.aea2747. Epub 2026 Sep 16.ABSTRACTHypertrophic cardiomyopathy (HCM) is marked by asymmetric cardiac wall thickening, hypercontractility, diastolic dysfunction, and fibrosis. Pathogenic sarcomere gene variants cause HCM, but comp

E Eleonora Adami

Cautionary Data on Antihypertensives in Aortic Diseases

No abstractHypertension. 2026 Oct;83(10):e27758. doi: 10.1161/HYPERTENSIONAHA.126.27758. Epub 2026 Sep 16.NO ABSTRACTPMID:42748206 | DOI:10.1161/HYPERTENSIONAHA.126.27758

G Guan Fan

Endothelial and platelet dysfunction in systemic sclerosis with pulmonary hypertension

PLoS One. 2026 Sep 16;21(9):e0357987. doi: 10.1371/journal.pone.0357987. eCollection 2026.ABSTRACTSystemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy, inflammation, and fibrosis, in which pulmonary hypertension (PH) is a major cause of mortality. In SSc,

T Thamonwan Imerbtham

Research on the use of bedside ultrasound to quickly evaluate neurological prognosis in patients with ROSC

PLoS One. 2026 Sep 16;21(9):e0358243. doi: 10.1371/journal.pone.0358243. eCollection 2026.ABSTRACTOBJECTIVE: This study aims to find a quick bedside ultrasonography evaluation technique that evaluates the optic nerve sheath diameter to eyeball transverse diameter (ONSD/ETD) ratio and middle cerebral

K Kerong Wang

Association between alcohol-Induced mental and behavioral disorders and comorbidities: Evidence from the Korea National Hospital Discharge In-depth Injury survey data

PLoS One. 2026 Sep 16;21(9):e0356598. doi: 10.1371/journal.pone.0356598. eCollection 2026.ABSTRACTBACKGROUND: Alcohol consumption is a significant social medium in South Korea, yet alcohol use disorders (AUD) impose a substantial public health burden. This study aimed to analyze sex-specific clinico

J Jieun Hwang

DEPP: A diabetes exercise prescription protocol knowledge base

PLOS Digit Health. 2026 Sep 16;5(9):e0001728. doi: 10.1371/journal.pdig.0001728. eCollection 2026 Sep.ABSTRACTExercise plays a critical role in diabetes management by improving glycemic control and reducing cardiovascular risk. However, personalizing exercise prescriptions to individual characterist

T Ting Bao

The changing landscape of Fabry disease: Impact of the inclusion of the GLA-gene in broader NGS or WES based panels on the phenotypic spectrum

PLoS One. 2026 Sep 16;21(9):e0358572. doi: 10.1371/journal.pone.0358572. eCollection 2026.ABSTRACTFabry disease (FD) is the most common lysosomal storage disorder in which a severe, classical phenotype as well as a milder, non-classical phenotype can be distinguished. In this study we investigated t

L Laura van Dussen

The missing middle: Exploring light-intensity physical activity and how it relates to health among adults in Canada

Health Rep. 2026 Sep 16;37(9):3-19. doi: 10.25318/82-003-x202600900001-eng.ABSTRACTBACKGROUND: The health benefits of moderate-to-vigorous physical activity (MVPA) are well established, as are the detrimental impacts of excess sedentary time. Less is known about the benefits of activity undertaken a

I Isabelle Michaud

Electrocardiographic and Arrhythmic Manifestations of End-Stage Atrial Myopathy in Patients With Longstanding Persistent or Permanent Atrial Fibrillation: A 3-Patient Case Series

Am J Case Rep. 2026 Sep 16;27:e953661. doi: 10.12659/AJCR.953661.ABSTRACTBACKGROUND Advanced atrial remodeling, often associated with atrial fibrosis, may be accompanied by severe atrial electrical dysfunction and a range of electrocardiographic and arrhythmic manifestations. Data on the clinical fe

F Frans Serpa

Mortality benefit and lifetime survival gains with vericiguat in HFrEF: Bayesian and actuarial analyses of the VICTOR trial

Eur J Heart Fail. 2026 Sep 16:xuag267. doi: 10.1093/ejhf/xuag267. Online ahead of print.ABSTRACTBACKGROUND: The VICTOR trial did not meet its primary composite endpoint of cardiovascular death or first hospitalization for heart failure (HF) but demonstrated a nominally significant reduction in the p

F Francesco Fioretti

Sequential Changes in Lipoprotein(a) During the First Month After Acute Coronary Syndrome: A Historical Prospective Cohort Study

Cardiology. 2026 Sep 16:1. doi: 10.1159/crd/absag011. Online ahead of print.ABSTRACTBACKGROUND: Lipoprotein(a) [Lp(a)] is an independent causal risk factor for atherosclerotic cardiovascular disease, with plasma concentrations largely determined by genetic factors. Despite its relative stability und

J Jose Javier Gomez-Barrado

Depression Symptoms and Advanced Cardiovascular-Kidney-Metabolic Syndrome in U.S. Adults: The Moderating Role of Sex

Biopsychosoc Sci Med. 2026 Sep 16. doi: 10.1097/PSY.0000000000001527. Online ahead of print.ABSTRACTOBJECTIVE: To examine the association between depressive symptoms and advanced cardiovascular-kidney-metabolic (CKM) syndrome among U.S. adults and to determine whether this association differs by dem

R Raphael A Fraser

In silico resistance prediction of oral streptococci to recommended prophylactic antibiotics to prevent infective endocarditis upon dental procedures

J Antimicrob Chemother. 2026 Sep 1;81(10):dkag320. doi: 10.1093/jac/dkag320.ABSTRACTBACKGROUND: For over 70 years, guidelines have recommended antibiotics for infective endocarditis (IE) prophylaxis before dental procedures, focusing on oral streptococci.OBJECTIVES: Our in silico study aimed to eval

G Gabriela Ceccon Chianca

Heart rate variability and baroreflex sensitivity derived from finger photoplethysmography during dynamic cerebral autoregulation assessments: Association with age, sex and time of day in healthy volunteers

Physiol Int. 2026 Sep 16:2060.2026.00860. doi: 10.1556/2060.2026.00860. Online ahead of print.ABSTRACTPURPOSE: Assessing dynamic cerebral autoregulation (dCA) noninvasively includes continuous blood pressure recording with a photoplethysmography device. We investigated in this retrospective study wh

M Manuel Bolognese

Efficacy and safety of minocycline in the treatment of intracerebral haemorrhage: study design and protocol for a multicentre, randomised, open-label, blinded endpoint clinical trial

Eur Stroke J. 2026 Sep 5;11(9):aakag084. doi: 10.1093/esj/aakag084.ABSTRACTBACKGROUND: Although minocycline is a multi-target neuroprotective drug, its potential benefit in patients with ICH remains unclear. This study primarily aims to assess the efficacy and safety of minocycline for the treatment

Y Yang Qu

Respiratory Syncytial Virus-Associated Disease in Children Receiving Intensive Care

JAMA Netw Open. 2026 Sep 1;9(9):e2634138. doi: 10.1001/jamanetworkopen.2026.34138.ABSTRACTIMPORTANCE: Data defining respiratory syncytial virus (RSV)-associated critical illness, risk factors, and outcomes among older children and adolescents are limited. As RSV prevention options expand, improved c

T Taylor L Olson

Efficacy and Safety of Semaglutide According to Frailty Status: A Post Hoc Analysis of the SELECT Randomized Clinical Trial

JAMA Cardiol. 2026 Sep 16. doi: 10.1001/jamacardio.2026.3566. Online ahead of print.ABSTRACTIMPORTANCE: Whether frailty influences the benefit-risk balance of glucagon-like peptide-1 receptor agonists (GLP-1 RA) is uncertain.OBJECTIVE: To evaluate whether frailty modifies the efficacy and safety of

J John W Ostrominski

LILRB4 Recruits SHP-1 to Enhance Oxidative Stress and Apoptosis, Aggravating Myocardial Ischemia-Reperfusion Injury

FASEB J. 2026 Sep 30;40(18):e72277. doi: 10.1096/fj.202501060RRR.ABSTRACTIschemia-reperfusion (I/R) leads to high levels of ROS, leading to cell death. The role of leukocyte immunoglobulin-like receptor B4 (LILRB4) in MIRI is unclear, despite its importance in oxidative stress and apoptosis regulati

J Jing Zhang