The moderating role of central adiposity, sex and age, on the association between animal- and plant-based protein intake and the 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002-2022)

Eur J Nutr. 2026 Jun 6;65(4):155. doi: 10.1007/s00394-026-03995-9.ABSTRACTPURPOSE: The aim of this study was to evaluate the role of central adiposity, sex and age, on the association between total-animal and total-plant based protein and the 20-year cumulative incidence of type 2 diabetes (T2D), am

I Ioanna Kechagia

Obesity, Liver Disease, and the Patient Voice: A Clinical Dialogue Podcast

Adv Ther. 2026 Jun 6. doi: 10.1007/s12325-026-03648-7. Online ahead of print.ABSTRACTObesity is a chronic, progressive disease defined by excess adiposity that can negatively affect a person's health. Approximately one billion people are living with obesity globally, though this estimate is shaped b

M Megha Poddar

Clinical outcomes following fractional flow reserve-guided revascularization using nicorandil versus conventional hyperemic agents: insights from the J-PRIDE Registry

Cardiovasc Interv Ther. 2026 Jun 6. doi: 10.1007/s12928-026-01300-3. Online ahead of print.ABSTRACTThe diagnostic accuracy of nicorandil for fractional flow reserve (FFR) measurement has been validated, whereas data on outcomes of FFR-guided revascularization strategy using nicorandil remain limited

K Kazutaka Nogi

Identification of Patient Clusters with Distinct Disease Progression Patterns Utilizing a Nationwide Finnish Population with Type 2 Diabetes

Diabetes Ther. 2026 Jun 6. doi: 10.1007/s13300-026-01879-z. Online ahead of print.ABSTRACTINTRODUCTION: Variability in the clinical presentation of patients with type 2 diabetes (T2D) is high and underlines the need for more personalized patient care. This nationwide study aimed to describe characte

K Kim Nygård

Exploring the associations between lifestyle and dietary patterns with preclinical alzheimer's disease: findings from La Rioja cohort study

Eur J Nutr. 2026 Jun 6;65(4):156. doi: 10.1007/s00394-026-04011-w.ABSTRACTPURPOSE: Modifiable lifestyle factors play an important role in maintaining brain health. This study aimed to investigate lifestyle behaviours, with a special focus on dietary patterns, associated with preclinical Alzheimer's

M María Iñiguez

Association between SGLT2 inhibitors and outcomes after heart transplant in patients with type 2 diabetes: A systematic review and meta-analysis

Heart Fail Rev. 2026 Jun 6;31(1):70. doi: 10.1007/s10741-026-10641-3.ABSTRACTSodium-glucose cotransporter 2 inhibitors (SGLT2i) are recommended for multiple populations-type 2 diabetes (T2D), chronic kidney disease, and heart failure-but their role after heart transplant (HTX) remains unclear. We se

T Thomaz Alexandre Costa

Chronic low-dose iron exposure induces GPX4-mediated resistance to ferroptosis in a human chondrocyte cell line

Cell Tissue Res. 2026 Jun 6;404(3):20. doi: 10.1007/s00441-026-04082-5.ABSTRACTOsteoarthritis (OA) is a degenerative joint disease closely linked to iron dysregulation. While the role of iron in OA is recognized, the precise mechanism of cell death remains unclear. This study aimed to elucidate how

A Asima Karim

Wild blueberry-derived polyphenol metabolites attenuate telomere shortening in an in vitro model of metabolic syndrome

Eur J Nutr. 2026 Jun 6;65(4):157. doi: 10.1007/s00394-026-04010-x.ABSTRACTPURPOSE: Metabolic syndrome (MetS) is a multifactorial disorder characterized by metabolic alterations that increase cardiovascular risk and may accelerate telomere attrition, potentially contributing to age-related diseases.

M Marco Rendine

PERsonalised Medicine for Intensification of Treatment (PERMIT) in type 2 diabetes mellitus: a target trial emulation from routine data

Health Technol Assess. 2026 Jun;30(47):1-28. doi: 10.3310/ASDB8011.ABSTRACTBACKGROUND: Evidence is required on the relative effectiveness of sulphonylureas, dipeptidyl peptidase-4 inhibitors or sodium-glucose cotransporter 2 inhibitors added to metformin for people with type 2 diabetes mellitus.OBJE

D David G Lugo-Palacios

Exercise attenuates cisplatin-induced anorexia-cachexia via modulation of hypothalamic inflammation and orexigenic signaling

Eur J Appl Physiol. 2026 Jun 6. doi: 10.1007/s00421-026-06232-7. Online ahead of print.ABSTRACTPURPOSE: Chemotherapy-induced anorexia cachexia (CAC) is a common adverse effect of cancer treatment and is associated with poor prognosis and reduced treatment tolerance. Despite its clinical relevance, e

S Se Hwan Park

Evolving Beyond Anatomy: The Synergistic Role of Baseline Physiology and Optimal Hemodynamics in Relieving Angina

No abstractJACC Asia. 2026 May 30:S2772-3747(26)00320-0. doi: 10.1016/j.jacasi.2026.04.026. Online ahead of print.NO ABSTRACTPMID:42249882 | DOI:10.1016/j.jacasi.2026.04.026

D Doyeon Hwang

Atrial Fibrillation After Mitral TEER: A Substrate-Dependent Disease

No abstractJACC Asia. 2026 May 30:S2772-3747(26)00319-4. doi: 10.1016/j.jacasi.2026.04.025. Online ahead of print.NO ABSTRACTPMID:42249881 | DOI:10.1016/j.jacasi.2026.04.025

P Panteleimon E Papakonstantinou

Extensive Cardiac Involvement in ANCA-Associated Vasculitis Presenting With Severe Aortic Regurgitation and Atrioventricular Block

JACC Case Rep. 2026 Jun 6:108761. doi: 10.1016/j.jaccas.2026.108761. Online ahead of print.ABSTRACTBACKGROUND: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis rarely presents with severe inflammatory cardiac involvement. Valvuloaortic disease with high-grade atrioventricular block i

D David Gabriel David-Pardo

Robotic-Assisted Aortic Valve Replacement in a Hybrid Approach to Concomitant Aortic Valve and Coronary Disease

JACC Case Rep. 2026 Jun 6:108764. doi: 10.1016/j.jaccas.2026.108764. Online ahead of print.ABSTRACTBACKGROUND: Robotic-assisted aortic valve replacement (RAVR) has emerged as a novel minimally invasive approach to surgically manage aortic valve disease.CASE SUMMARY: A 74-year-old man presented with

O Omar Toubat

Phenotypic Spectrum of Cardiac Involvement in Eosinophilic Granulomatosis With Polyangiitis

JACC Case Rep. 2026 Jun 6:108756. doi: 10.1016/j.jaccas.2026.108756. Online ahead of print.ABSTRACTBACKGROUND: Cardiac involvement in eosinophilic granulomatosis with polyangiitis (EGPA) is a major determinant of morbidity and mortality and may occur independently of systemic disease activity.CASE S

Z Zoha Majeed

Hypercontractile Phenotype at Rest in Chronic Coronary Syndromes Predicts Impaired Functional Reserve and Increased Mortality

ESC Heart Fail. 2026 Jun 6:xvag151. doi: 10.1093/eschf/xvag151. Online ahead of print.ABSTRACTBACKGROUND: Transthoracic echocardiography (TTE) identifies a hypercontractile phenotype (HP) in chronic coronary syndromes (CCS), characterized by elevated resting left ventricular (LV) elastance (Force =

Q Quirino Ciampi

Noninvasive Left Ventricular Pressure-Strain Loop for Evaluating Changes in Left Ventricular Function in Colorectal Cancer Patients After Chemotherapy

Echocardiography. 2026 Jun;43(6):e70519. doi: 10.1111/echo.70519.ABSTRACTOBJECTIVE: To noninvasively monitor cardiac functional changes throughout chemotherapy in colorectal cancer patients using pressure-strain analysis, validate their predictive value for early detection of subclinical cardiac dys

X Xueting Guo

Physiological and Sleep Profiles in Insomnia, OSA and COMISA: A Comparative Study in Portugal and Spain

J Sleep Res. 2026 Jun 5:e70367. doi: 10.1111/jsr.70367. Online ahead of print.ABSTRACTInsomnia and obstructive sleep apnea (OSA) are common sleep disorders that often co-occur as comorbid insomnia and sleep apnea (COMISA), worsening health outcomes. This study characterized and compared the physiolo

M Margarida Carvalho

Advancing Brain and Body Vascular Imaging in Bipolar Disorder: A Report From the International Society for Bipolar Disorders Vascular Task Force

Bipolar Disord. 2026 Jun;28(4):e70120. doi: 10.1111/bdi.70120.ABSTRACTOBJECTIVES: The heart-brain nexus is increasingly recognized as important for human health. Nonetheless, integration of this perspective in research and treatment remains limited in psychiatry, particularly in bipolar disorder (BD

M Megan Mio

Early Prone Positioning After Acute Type A Aortic Dissection Surgery for Moderate-to-Severe Acute Respiratory Distress Syndrome Is Safe and Shortens Duration of Mechanical Ventilation

Crit Care Explor. 2026 Jun 8;8(6):e1420. doi: 10.1097/CCE.0000000000001420. eCollection 2026 Jun 1.ABSTRACTIMPORTANCE: Evidence for prone positioning in post-cardiac surgery acute respiratory distress syndrome (ARDS), especially after acute type A aortic dissection (ATAAD) repair, is extremely limit

H Huilong Chen

Intraoperative tension pneumothorax during laparoscopic cholecystectomy as a presentation of delayed traumatic diaphragmatic hernia: a case report

J Cardiothorac Surg. 2026 Jun 5. doi: 10.1186/s13019-026-04363-8. Online ahead of print.ABSTRACTBACKGROUND: Traumatic diaphragmatic hernia (TDH) may present months to years after blunt injury and can mimic biliary or pulmonary disease. Right-sided TDH is particularly prone to delayed recognition bec

J Jihyong Yun

PROTAC-mediated PCSK9 degradation attenuates atherosclerosis and improves plaque composition via suppression of NF-κB/TNF-α pathway

BMC Med. 2026 Jun 5. doi: 10.1186/s12916-026-04976-9. Online ahead of print.ABSTRACTBACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a critical therapeutic target for managing hyperlipidemia and atherosclerosis. We developed Cadd4, a synthetic proteolysis-targeting chimera (PROTA

X Xin Wang

White matter microstructure fingerprint of cerebral small vessel disease

Brain. 2026 Jun 6:awag200. doi: 10.1093/brain/awag200. Online ahead of print.ABSTRACTWhite matter hyperintensities (WMHs) are the imaging hallmark of cerebral small vessel disease (SVD), yet their microstructural composition, spatial heterogeneity, and relationship to diffuse normal-appearing white

A Aurélie Bussy

APOSCREEN-1 - a prospective, single-arm clinical trial for the implementation of a pharmacy-based screening for cardiovascular-kidney-metabolic risk factors in Schleswig-Holstein

BMC Nephrol. 2026 Jun 5. doi: 10.1186/s12882-026-05090-x. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome has emerged as a major global health burden and driver of cardiovascular disease (CVD), the leading cause of death worldwide. Effective management of CKM

E Eric Amelunxen