J Health Popul Nutr. 2025 Dec 14. doi: 10.1186/s41043-025-01187-5. Online ahead of print.ABSTRACTBACKGROUND: The prognostic utility of the triglyceride-glucose (TyG) index and its anthropometry-enhanced variants (TyG-WC, TyG-WHtR, TyG-BMI) for mortality risk in advanced cardiovascular-liver-kidney-m
Gut Pathog. 2025 Dec 14. doi: 10.1186/s13099-025-00788-z. Online ahead of print.ABSTRACTAging is a complex process marked by the gradual accumulation of impairments in molecules and tissues, leading to frailty and dysfunction. This decline is a significant risk factor for many debilitating condition
Rheumatology (Oxford). 2025 Dec 14:keaf672. doi: 10.1093/rheumatology/keaf672. Online ahead of print.ABSTRACTOBJECTIVES: To assess the relationship between disease duration and the prevalence/distribution of nailfold videocapillaroscopy (NVC) patterns, named according to the current classification a
Cardiovasc Diabetol Endocrinol Rep. 2025 Dec 15;11(1):40. doi: 10.1186/s40842-025-00252-6.ABSTRACTBACKGROUND: Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy characterized by progressive extracellular amyloid deposition, leading to restrictive heart failure (HF) and high morbidity. Diseas
Cardiovasc Diabetol. 2025 Dec 14. doi: 10.1186/s12933-025-03034-7. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) is associated with increased atherosclerotic cardiovascular disease (ASCVD) risk. However, evidence on proteomic mechanisms linking MASLD
NPJ Digit Med. 2025 Dec 14. doi: 10.1038/s41746-025-02228-3. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) remain the leading cause of global mortality, with early detection critical for improving patient outcomes. Photoplethysmography (PPG) is a widely used, non-invasive signal in bo
Mil Med Res. 2025 Dec 15;12(1):92. doi: 10.1186/s40779-025-00676-2.ABSTRACTBACKGROUND: In 2022, China experienced an unprecedented heatwave event, raising concerns about the health impacts of heatwaves. This study aims to understand the devastating health risk of the exceptional heatwave in 2022 by
J Mol Med (Berl). 2025 Dec 15;104(1):3. doi: 10.1007/s00109-025-02619-9.ABSTRACTApolipoprotein A5 (ApoA5) and Cell Death-Inducing DNA Fragmentation Factor-like Effector C (CIDEC) are involved in hepatic lipid metabolism and implicated in metabolic dysfunction-associated steatotic liver disease (MASL
Eur J Cardiothorac Surg. 2025 Dec 14:ezaf450. doi: 10.1093/ejcts/ezaf450. Online ahead of print.ABSTRACTOBJECTIVES: Type B aortic dissection (TBAD) is rare in patients aged ≤30 years, and data on this population remain limited. This study aimed to characterize the underlying etiology, and outcomes o
Sci Rep. 2025 Dec 14. doi: 10.1038/s41598-025-31001-5. Online ahead of print.ABSTRACTCeramides (Cer) drive cardiometabolic disease (CMD) by promoting lipotoxicity and oxidative stress, yet their therapeutic potential remains underexplored. We investigated Cer dysregulation in high-fat diet (HFD) fed
Nat Commun. 2025 Dec 14. doi: 10.1038/s41467-025-66670-3. Online ahead of print.ABSTRACTMost first-line pharmacotherapeutic strategies for depression aim to boost serotonin and norepinephrine levels. However, 35% of patients with depression do not respond adequately to these treatments or experience
Signal Transduct Target Ther. 2025 Dec 15;10(1):402. doi: 10.1038/s41392-025-02502-6.ABSTRACTCellular senescence is deeply involved in physiological homeostasis, development, tissue repair, aging, and diseases. Senescent cells (SnCs) accumulate in aged tissues and exert deleterious effects by secret
Cardiovasc Diabetol. 2025 Dec 14. doi: 10.1186/s12933-025-03038-3. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The atherogenic index of plasma (AIP) reflects atherogenic dyslipidemia and triglyceride-glucose (TyG) index is a surr
Egypt Heart J. 2025 Dec 14;77(1):111. doi: 10.1186/s43044-025-00709-0.ABSTRACTBACKGROUND: The supply of donor hearts has fallen short of the increasing demand. This widening gap has led to a crisis marked by long waiting times and high mortality rates among those on waiting lists. This study aimed t
Br J Clin Pharmacol. 2025 Dec 14. doi: 10.1002/bcp.70416. Online ahead of print.ABSTRACTAIMS: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have well-documented cardiovascular benefits. However, the cardiovascular benefits of early SGLT2i use in diabetics experiencing acute myocardial infarctio
Immun Inflamm Dis. 2025 Dec;13(12):e70305. doi: 10.1002/iid3.70305.ABSTRACTBACKGROUND: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing cardiova
J Clin Lipidol. 2025 Nov 13:S1933-2874(25)00513-6. doi: 10.1016/j.jacl.2025.11.010. Online ahead of print.ABSTRACTBACKGROUND: Despite the intensive approach recommended by the 2019 European Society of Cardiology/European Atherosclerosis Society guidelines, low-density lipoprotein cholesterol (LDL-C)
Ren Fail. 2025 Dec;47(1):2590798. doi: 10.1080/0886022X.2025.2590798. Epub 2025 Dec 14.ABSTRACTThis study aimed to compare blood pressure variability (BPV) between maintenance hemodialysis (HD) and peritoneal dialysis (PD) patients and evaluate its association with cerebrovascular event risk. A pros
Arch Pediatr. 2025 Dec;32(7S1):7S20-7S24. doi: 10.1016/S0929-693X(25)00249-0.ABSTRACTDuchenne muscular dystrophy (DMD) encompasses early skeletal muscle involvement with myocardial disease characterized by progressive fibrosis and the gradual development of dilated cardiomyopathy, which become almos
J Heart Lung Transplant. 2026 Jan;45(1):1-4. doi: 10.1016/j.healun.2025.11.008.ABSTRACTThe International Society for Heart and Lung Transplantation Consensus for Perioperative Utilization of Extracorporeal Life Support in Lung Transplantation consists of 111 Delphi-derived statements across 3 separa
Semin Radiat Oncol. 2026 Jan;36:61-76. doi: 10.1016/j.semradonc.2025.10.003.ABSTRACTStereotactic arrhythmia radioablation (STAR) has emerged as a novel, noninvasive therapeutic option for patients with drug- and ablation-refractory ventricular tachycardia (VT). Derived from stereotactic body radioth
Environ Health Prev Med. 2025;30:100. doi: 10.1265/ehpm.25-00362.ABSTRACTBACKGROUND: Subclinical hypothyroidism (SCH) has been reported to be associated with lower endothelial progenitor (CD34-positive) cell count, whereas an inverse association between circulating CD34-positive cell count and heigh
Int J Cardiol. 2025 Dec 12:134098. doi: 10.1016/j.ijcard.2025.134098. Online ahead of print.ABSTRACTINTRODUCTION: In athletes undergoing pre-participation screening (PPS), ambulatory ECG monitoring is often prescribed in cases of arrhythmias at baseline or suspicious symptoms. Since performing an ex
Int J Cardiol. 2025 Dec 12:134097. doi: 10.1016/j.ijcard.2025.134097. Online ahead of print.ABSTRACTBACKGROUND: The Italian pre-participation screening (PPS) program includes a simplified 3-min step test to assess cardiovascular responses in paediatric athletes, yet limited data exist on the cardiov
