Artif Intell Med. 2025 Nov 17;171:103308. doi: 10.1016/j.artmed.2025.103308. Online ahead of print.ABSTRACTBACKGROUND: Four-dimensional (4D) flow magnetic resonance imaging (MRI) has evolved into an advanced non-invasive imaging technique that enables comprehensive assessment of blood flow in cardio
Stem Cell Res. 2025 Nov 18;89:103874. doi: 10.1016/j.scr.2025.103874. Online ahead of print.ABSTRACTFamilial hypercholesterolemia is an autosomal dominant genetic disorder that often leads to abnormally high cholesterol levels in the body, which is closely related to early-onset coronary heart disea
Protein Cell. 2025 Nov 22:pwaf103. doi: 10.1093/procel/pwaf103. Online ahead of print.ABSTRACTLymphatic malformations (LMs) are debilitating and potentially life-threatening diseases. However, the immune phenotype of circulating cells and underlying molecular mechanisms in LMs remain poorly understo
Methods Mol Biol. 2026;2986:547-564. doi: 10.1007/978-1-0716-4976-3_25.ABSTRACTMicroRNAs (miRNAs) are regulatory RNA molecules that adjust the levels of proteins in cells to maintain cellular homeostasis during essential cellular events or stress conditions. A large array of studies are available in
Ann Surg Oncol. 2025 Nov 22. doi: 10.1245/s10434-025-18795-4. Online ahead of print.ABSTRACTBACKGROUND: Social determinants of health are increasingly recognized as critical contributors to surgical outcomes. The Social Vulnerability Index (SVI), a composite measure developed by the Centers for Dise
Apoptosis. 2025 Nov 22. doi: 10.1007/s10495-025-02189-8. Online ahead of print.ABSTRACTProgrammed cell death has evolved from the classical concept of apoptosis to a diverse repertoire that includes necroptosis, pyroptosis, ferroptosis, cuproptosis, paraptosis, panoptosis, and even the reversal proc
Adv Exp Med Biol. 2026;1487:317-323. doi: 10.1007/978-3-032-03398-7_31.ABSTRACTINTRODUCTION: Alagille syndrome (ALGS) is a rare autosomal dominant disorder with several clinical manifestations including facial, hepatic, cardiovascular, skeletal, and renal complications. ALGS is a result of pathogeni
Adv Exp Med Biol. 2026;1487:85-98. doi: 10.1007/978-3-032-03398-7_10.ABSTRACTBACKGROUND: The most common genetic cause associated with thrombophilia is Leiden mutation (G1691A) of the coagulation factor V (F5) gene.MATERIALS AND METHODS: Data collected anonymously from 355 unrelated Greeks examined
Adv Exp Med Biol. 2026;1487:71-84. doi: 10.1007/978-3-032-03398-7_9.ABSTRACTThe innate immune response is started immediately following brain ischemia, resulting in adaptive immunity. More and more experimental evidence has indicated that the immune response caused by cerebral ischemia plays a cruci
Metab Brain Dis. 2025 Nov 22;40(8):323. doi: 10.1007/s11011-025-01686-8.ABSTRACTHua Feng Dan (HFD) has demonstrated definitive efficacy in the treatment of ischemic stroke (IS); however, its active components and underlying mechanisms of action remain unclear. This study employed a rat model of midd
AMB Express. 2025 Nov 22. doi: 10.1186/s13568-025-01986-3. Online ahead of print.ABSTRACTHigh-fat diet (HFD) consumption poses a significant public health threat due to its strong association with obesity, hyperlipidemia, cardiovascular diseases, and metabolic syndrome. While Akkermansia muciniphila
Mol Neurobiol. 2025 Nov 22;63(1):140. doi: 10.1007/s12035-025-05291-9.ABSTRACTNeurological diseases, such as stroke, are typically deemed refractory because of the adult mammalian brain's poor ability to self-repair and regenerate, resulting in irreparable cellular damage. Neural stem cells (NSCs) h
Neurosurg Rev. 2025 Nov 22;49(1):23. doi: 10.1007/s10143-025-03920-4.ABSTRACTChronic subdural hematoma (cSDH) is the most common form of intracranial hemorrhage, with increasing incidence in older population. Despite surgical interventions, recurrence rates remain high, varying between 5 and 37%. Id
Environ Sci Technol. 2025 Nov 22. doi: 10.1021/acs.est.5c13209. Online ahead of print.ABSTRACTDespite the established associations between air pollution and cardiovascular diseases (CVD), the biological mechanisms underlying its toxic effects remain largely unknown. We investigated whether exposure
Exp Physiol. 2025 Nov 22. doi: 10.1113/EP093109. Online ahead of print.ABSTRACTEndothelial dysfunction drives obesity-related complications. Doppler ultrasound measurement of blood flow during 1-min passive leg movements (PLM) is a valuable non-invasive tool for assessing endothelial function and ni
No abstractJACC Heart Fail. 2025 Nov 20:102818. doi: 10.1016/j.jchf.2025.102818. Online ahead of print.NO ABSTRACTPMID:41273316 | DOI:10.1016/j.jchf.2025.102818
Eur J Sport Sci. 2025 Dec;25(12):e70091. doi: 10.1002/ejsc.70091.ABSTRACTMenopause is associated with increased blood pressure (BP) and vasomotor symptoms (VMS), both elevating cardiovascular risk. Exercise can induce postexercise hypotension (PEH), with responses varying by exercise type and popula
FASEB J. 2025 Nov 30;39(22):e71199. doi: 10.1096/fj.202501651RRR.ABSTRACTAbdominal aortic aneurysm (AAA) is a major vascular pathology with high morbidity and mortality. Phenotypic changes of vascular smooth muscle cells (VSMC) play a key role in AAA pathogenesis. In the present study, we investigat
Anat Rec (Hoboken). 2025 Nov 22. doi: 10.1002/ar.70084. Online ahead of print.ABSTRACTThe intestinal epithelial barrier is formed by epithelial cells and their associated junctional complexes, comprising tight junctions, adherens junctions, and desmosomes. The junctional complex is composed of speci
Rejuvenation Res. 2025 Nov 18. doi: 10.1177/15491684251396176. Online ahead of print.ABSTRACTAging is characterized by a progressive decline in physiological integrity, often accompanied by chronic inflammation and immune dysregulation. Immunoglobulin G (IgG), a key effector of humoral immunity, und
CNS Neurosci Ther. 2025 Nov;31(11):e70662. doi: 10.1111/cns.70662.ABSTRACTBACKGROUND: Cerebral ischemia-reperfusion (I/R) injury is a major consequence of ischemic stroke, leading to blood-brain barrier (BBB) disruption, neuroinflammation, and neuronal death. Recent studies suggest that tetrahydrocu
Brain Behav. 2025 Nov;15(11):e71052. doi: 10.1002/brb3.71052.ABSTRACTBACKGROUND: Endovascular thrombectomy (EVT) is the standard treatment for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). However, the role of preceding intravenous thrombolysis (IVT) in patients with sizable is
Brain Behav. 2025 Nov;15(11):e71042. doi: 10.1002/brb3.71042.ABSTRACTBACKGROUND: Mitochondrial D-loop methylation leads to abnormal cerebral angiogenesis. This study examines its role in vascular phenotypes of moyamoya disease (MMD).METHOD: Blood samples from 96 intracranial artery stenosis/occlusio
J Gastroenterol Hepatol. 2025 Nov 21. doi: 10.1111/jgh.70162. Online ahead of print.ABSTRACTBACKGROUND/AIMS: The association between metabolic dysfunction-associated steatotic liver disease (MASLD), liver fibrosis, and coronary artery calcification (CAC) remains uncertain. We investigated their rela
