Repeated intravenous thrombolysis for ischaemic stroke with medium to large vessel occlusion presenting within 4.5 hours of onset with tenecteplase in China (RITIS-TNK2): protocol for a prospective, randomised, open-label, blinded assessment of outcome and multicentre study

BMJ Open. 2026 Aug 21;16(8):e120918. doi: 10.1136/bmjopen-2026-120918.ABSTRACTINTRODUCTION: Recanalisation rates following standard intravenous thrombolysis (IVT) for acute ischaemic stroke due to medium or large vessel occlusion (MeVO/LVO) remain unsatisfactory, leading to poor clinical outcomes. T

Z Zhi-Guo Yao

Walking a tightrope: the safety and efficacy of oral anticoagulants in atrial fibrillation patients with prior intracranial haemorrhage: a systematic review and meta-analysis

Open Heart. 2026 Aug 21;13(2):e004264. doi: 10.1136/openhrt-2026-004264.ABSTRACTINTRODUCTION: The optimal anticoagulation strategy for patients with atrial fibrillation (AF) and prior intracranial haemorrhage (ICH) remains uncertain. Although direct oral anticoagulants (DOACs) have demonstrated a mo

A Andreas Mercyan Anggitama

Pulp and Periapical Biology: The Foundations of Personalized Endodontics

J Endod. 2026 Aug 21:S0099-2399(26)00459-0. doi: 10.1016/j.joen.2026.08.027. Online ahead of print.ABSTRACTEndodontic care has traditionally focused on the management of local disease conditions and long-term function. As the burden of pulpal and periapical disease remains significant, the concept o

O Ove A Peters