Increased Risk of Myocardial Infarction and Stroke Among Multiracial Asian and Pacific Islander Adults With Diabetes: Evidence From Electronic Health Records

J Am Heart Assoc. 2026 Apr 22:e043657. doi: 10.1161/JAHA.125.043657. Online ahead of print.ABSTRACTBACKGROUND: Type 2 diabetes (henceforth diabetes) contributes to cardiovascular disease burden. Compared with Non-Hispanic White individuals, Asian American and Pacific Islander individuals have lower

A Adrian M Bacong

Resource Use Following Revascularization for Multivessel Coronary Artery Disease

J Am Heart Assoc. 2026 Apr 22:e049340. doi: 10.1161/JAHA.126.049340. Online ahead of print.ABSTRACTBACKGROUND: Coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) are the 2 revascularization modalities for patients with severe coronary artery disease. While CABG has o

R Ryaan El-Andari

From Failure to Promise: Obicetrapib and the Renaissance of Cholesteryl Ester Transfer Protein Inhibition in Atherosclerotic Cardiovascular Disease

J Am Heart Assoc. 2026 Apr 22:e047676. doi: 10.1161/JAHA.125.047676. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular diseases are a leading global cause of death, driven significantly by elevated low-density lipoprotein cholesterol levels. Despite the emergence of effective lipid-loweri

S Sudesh Prajapathi

Targeting Integrin β3 in Endothelial Cells Attenuates Cardiac Fibrosis Through the Calcium-Calmodulin-Dependent Protein Kinase IIα- cAMP-Responsive Element Binding Protein 1 Signaling Axis in Pressure Overload-Induced Heart Failure

J Am Heart Assoc. 2026 Apr 22:e046276. doi: 10.1161/JAHA.125.046276. Online ahead of print.ABSTRACTBACKGROUND: Endothelial-to-mesenchymal transition (EndMT) is a key contributor to cardiac fibrosis, yet the role and underlying mechanisms of endothelial integrin β3 (ITGB3) activation in EndMT remain

M Mengwen Wang

Comparative Efficacy of Statins Versus PCSK9 Inhibitors in Coronary Heart Disease Treatment

J Am Heart Assoc. 2026 Apr 22:e047923. doi: 10.1161/JAHA.125.047923. Online ahead of print.ABSTRACTBACKGROUND: Combining PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors with statins significantly lowers low-density lipoprotein cholesterol and reduces cardiovascular events in patient

L Linchan Yu

Age at Coronary Heart Disease Onset, Genetic Susceptibility, and Subsequent Risk of Stroke

J Am Heart Assoc. 2026 Apr 22:e045895. doi: 10.1161/JAHA.125.045895. Online ahead of print.ABSTRACTBACKGROUND: Coronary heart disease (CHD) has been established as a risk factor for stroke. The study aimed to assess how age at CHD onset influences stroke risk and interacts with genetic predispositio

Y Yi Qi

Genetic Architecture of Trans-Laminar Cribrosa Pressure Difference and Primary Open-Angle Glaucoma

Invest Ophthalmol Vis Sci. 2026 Apr 1;67(4):51. doi: 10.1167/iovs.67.4.51.ABSTRACTPURPOSE: The purpose of this study was to investigate whether the genetic architecture of translaminar cribrosa pressure difference (TLCPD) provides genetic insights based on dual-pressure theory beyond intraocular pre

I In-Shik Hong

Long-Term Cardiovascular Impact of Postpartum Treatment After Hypertensive Disorders of Pregnancy: Population-Based Cohort Study

BJOG. 2026 Apr 22. doi: 10.1111/1471-0528.70251. Online ahead of print.ABSTRACTOBJECTIVE: To assess whether early antihypertensive treatment after Hypertensive Disorders of Pregnancy (HDP) influences subsequent development of cardiovascular complications.DESIGN AND SETTING: Population-based nationwi

E Emmanuel Simon

Global Longitudinal Assessment of MASLD Using Magnetic Resonance Elastography (GOLDMINE): A Multi-Center, International Prospective Cohort Study of Imaging Biomarkers in MASLD Clinical Outcomes

Aliment Pharmacol Ther. 2026 Apr 22. doi: 10.1111/apt.70696. Online ahead of print.ABSTRACTBACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) exhibits marked heterogeneity in fibrosis progression and liver-related outcomes. Liver biopsy is not feasible for longitudinal risk

S Suzanne Sharpton

Rare KDR Variants Define a Distinct Genetic Contribution to Congenital Heart Disease

No abstractCirc Genom Precis Med. 2026 Apr 22:e005659. doi: 10.1161/CIRCGEN.125.005659. Online ahead of print.NO ABSTRACTPMID:42017254 | DOI:10.1161/CIRCGEN.125.005659

F Feria A Ladha

TEER Beyond Contraindication: Resolving Recurrent Cerebral Infarction in a Patient With Degenerative Mitral Regurgitation

JACC Case Rep. 2026 Apr 13:108134. doi: 10.1016/j.jaccas.2026.108134. Online ahead of print.ABSTRACTBACKGROUND: Degenerative mitral regurgitation (MR) is a common valvular heart disease, with transcatheter edge-to-edge repair (TEER) an alternative option for high-risk patients. Non-bacterial thrombo

M Minghao Ma

Association Between Cardiovascular Polygenic Risk and White Matter Hyperintensities: An Observational Study From the UK Biobank

Hypertension. 2026 Apr 22. doi: 10.1161/HYPERTENSIONAHA.125.26388. Online ahead of print.ABSTRACTBACKGROUNDS: White matter hyperintensities (WMH), a marker of cerebral small vessel disease, are associated with cardiovascular risk factors and disease. However, the extent to which these associations a

Y Yongfang Zhang

Scalable System-Wide CYP2C19 Pharmacogenomic Testing Reveals 38% Excess Incidence of Adverse Events in Metabolizers Receiving Inappropriate Prescriptions

No abstractCirc Genom Precis Med. 2026 Apr 22:e005363. doi: 10.1161/CIRCGEN.125.005363. Online ahead of print.NO ABSTRACTPMID:42017228 | DOI:10.1161/CIRCGEN.125.005363

N Natalie Telis

How to Image Myocarditis

Circ Cardiovasc Imaging. 2026 Apr 22:e018547. doi: 10.1161/CIRCIMAGING.125.018547. Online ahead of print.ABSTRACTMyocarditis is an inflammatory disease involving the heart muscle and potentially the pericardium. While there are many potential causative agents, commonly grouped into infectious (viral

J Jan Gröschel

Biobank-Scale Plasma Proteomics Identifies Novel Biomarkers in Hypertrophic Cardiomyopathy

Circ Genom Precis Med. 2026 Apr 22:e005325. doi: 10.1161/CIRCGEN.125.005325. Online ahead of print.ABSTRACTBACKGROUND: Hypertrophic cardiomyopathy (HCM) is characterized by substantial heterogeneity in both clinical phenotype and risk of adverse outcomes, including heart failure and sudden cardiac d

J Jonathan H Chan

Predictive factors for new-onset atrial fibrillation in patients with embolic stroke of undetermined source and left atrial enlargement - development of a risk score

Cardiol J. 2026;33:e00226041. doi: 10.5603/cj.108712.ABSTRACTBACKGROUND: In patients with embolic stroke of undetermined source (ESUS), detecting new-onset atrial fibrillation (AF) is crucial because it leads to treatment change and reduces stroke recurrence and mortality. However, the high cost and

J Jorge Melero-Polo

Ensitrelvir for the treatment of hospitalized adults with COVID-19: an international phase 3 randomized placebo-controlled trial

Clin Infect Dis. 2026 Apr 22:ciag272. doi: 10.1093/cid/ciag272. Online ahead of print.ABSTRACTBACKGROUND: Antivirals remain an important treatment strategy for persons who experience severe and life-threatening COVID-19. Ensitrelvir is an oral 3CL protease inhibitor with potent antiviral activity.ME

J Jason V Baker

In vitro and in vivo activity of daptomycin plus ceftaroline for the treatment of experimental endocarditis due to Enterococcus faecalis with and without high-level aminoglycoside resistance

J Antimicrob Chemother. 2026 Apr 3;81(5):dkag136. doi: 10.1093/jac/dkag136.ABSTRACTOBJECTIVES: Effective alternatives to standard of care treatment for E. faecalis infective endocarditis (EFIE) are needed. Some in vitro studies have suggested daptomycin and ceftaroline have synergistic activity agai

M María-Alexandra Cañas

A quantitative in vivo CRISPR-imaging platform identifies regulators of hyperplastic and hypertrophic adipose morphology in zebrafish

Elife. 2026 Apr 22;14:RP107327. doi: 10.7554/eLife.107327.ABSTRACTAdipose tissues exhibit a remarkable capacity to expand, regress, and remodel in response to energy status. The cellular mechanisms underlying adipose remodelling are central to metabolic health. Hypertrophic remodelling - characteris

R Rebecca Wafer

Sex Differences in Long COVID Prevalence Over One year After the Acute Phase, and Related Risk Factors. The GINA-COVID Cohort Study

Int J Womens Health. 2026 Apr 16;18:538491. doi: 10.2147/IJWH.S538491. eCollection 2026.ABSTRACTBACKGROUND: This 1-year cohort study aimed to track long COVID prevalence, identify associated risk factors, and assess its association with hospitalization.METHODS: The GINA-COVID cohort study included 2

M Mar Alvarez-Pedrerol

Beyond 'One Size Fits All': Abatement of Linezolid-Induced Thrombocytopenia Through Therapeutic Drug Monitoring and Precision Dosing-A Case Study

Case Rep Infect Dis. 2026 Apr 19;2026:3214119. doi: 10.1155/crdi/3214119. eCollection 2026.ABSTRACTBACKGROUND: Linezolid is an oxazolidinone antibiotic used in the treatment of Gram-positive bacterial infections. However, its prolonged use is often limited by adverse effects, including thrombocytope

K Kennedy C Concannon

Identification and functional analysis of NAD+ metabolism-related gene NT5E in pulmonary hypertension

Front Genet. 2026 Apr 7;17:1787122. doi: 10.3389/fgene.2026.1787122. eCollection 2026.ABSTRACTBACKGROUND: Pulmonary hypertension (PH) is a severe progressive disease characterised by elevated pulmonary vascular resistance and right ventricular hypertrophy. Increasing evidence has highlighted the vit

Y Yanan Chu

Cardiovascular Events and Management Strategies Including Tyrosine Kinase Inhibitor Switching, Dose Reduction, and Discontinuation in Chronic Myeloid Leukemia: A Single-Center Retrospective Study

Cureus. 2026 Mar 21;18(3):e105578. doi: 10.7759/cureus.105578. eCollection 2026 Mar.ABSTRACTThe development of tyrosine kinase inhibitors (TKIs) has dramatically improved the treatment outcomes of the chronic myelogenous leukemia-chronic phase (CML-CP). However, cardiovascular events (CVEs), such as

N Nobue Sato

Penile Reconstruction With a Pedicled Suprapubic Flap After Cutaneous Necrosis Secondary to Modeling Substance Disease: A Case Report

Cureus. 2026 Mar 21;18(3):e105606. doi: 10.7759/cureus.105606. eCollection 2026 Mar.ABSTRACTPenile cutaneous necrosis is an uncommon but severe clinical condition that may result from necrotizing infections, vascular compromise, or complications related to cosmetic procedures. The subcutaneous injec

J Jonathan Alberto Osio-Muñoz