Potential Association Between Apical Periodontitis and Cardiovascular Disease: A Narrative Review of Evidence and Clinical Implications

Anatol J Cardiol. 2026 May 14. doi: 10.14744/AnatolJCardiol.2026.6298. Online ahead of print.ABSTRACTApical periodontitis (AP) affects 52% of adults globally, yet its systemic cardiovascu-lar implications remain understudied compared to periodontal disease. This narrative review synthesizes current

Y Yiyun Liang

Targeted Therapy for ANCA Associated Vasculitis: Where Have We Been?

Nephrology (Carlton). 2026 May;31(5):e70215. doi: 10.1111/nep.70215.ABSTRACTAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a complex group of autoimmune diseases characterized by systemic small-vessel inflammation. Although glucocorticoids combined with conventional immun

L Liuyue Zeng

Repair of a unicuspid aortic valve with root stabilization

Multimed Man Cardiothorac Surg. 2026 May 13;2026. doi: 10.1510/mmcts.2025.158.ABSTRACTA unicuspid aortic valve morphology is a relatively rare variant and may require surgical correction early in life for regurgitation. In the majority of cases, a patch is required for repair, which degenerates and

I Igor E Konstantinov

Prior Myocardial Infarction and Cognitive Decline: The REGARDS Cohort

Stroke. 2026 May 14. doi: 10.1161/STROKEAHA.125.053444. Online ahead of print.ABSTRACTBACKGROUND: Acute myocardial infarction (MI) is associated with subsequent cognitive decline. Whether the detection of prior MI using routine ECG and self-reported history can identify different trajectories of cog

M Mohamed Ridha

Artificial Intelligence in Peripheral Artery Disease: A Science Advisory From the American Heart Association

Circ Popul Health Outcomes. 2026 May 14:e000146. doi: 10.1161/HCQ.0000000000000146. Online ahead of print.ABSTRACTArtificial intelligence shows promise for improving care for peripheral artery disease through earlier detection, improved risk stratification, more tailored treatment planning, and more

A Arash Harzand

Efficacy of the Shear Stress Pattern Computed in Coronary Artery Reconstruction Models With and Without Side Branches in Predicting Plaque Progression

Arterioscler Thromb Vasc Biol. 2026 May 14. doi: 10.1161/ATVBAHA.126.324466. Online ahead of print.ABSTRACTBACKGROUND: The incorporation of side branches in vessel geometry influences wall shear stress (WSS) distribution. However, complete vessel reconstruction is time-consuming, and there is no evi

A Anantharaman Ramasamy

SAHH Deficiency Decreases Stability of Atherosclerotic Plaque and Induces VSMC Phenotype Switching via Epigenetic Upregulation of KLF4 and OCT4

Arterioscler Thromb Vasc Biol. 2026 May 14. doi: 10.1161/ATVBAHA.125.324115. Online ahead of print.ABSTRACTBACKGROUND: S-adenosylhomocysteine (SAH) is a novel risk factor of cardiovascular disease. SAHH (S-adenosylhomocysteine hydrolase) inhibition leads to SAH accumulation and promotes the formatio

S Si Liu

Perk Is Dispensable for Smooth Muscle Cell Phenotype Switching in Atherosclerosis

Arterioscler Thromb Vasc Biol. 2026 May 14. doi: 10.1161/ATVBAHA.125.323869. Online ahead of print.ABSTRACTBACKGROUND: Smooth muscle cell (SMC) derived cells form the bulk of cells in atherosclerotic lesions and modulate lesion stability and cardiovascular disease outcomes. Unfolded protein response

L Lucie Y Zhu

PCSK9 inhibitors: an updated patent review 2024-2025

Expert Opin Ther Pat. 2026 May 14. doi: 10.1080/13543776.2026.2674748. Online ahead of print.ABSTRACTINTRODUCTION: Proprotein convertase subtilisin/kexin 9 (PCSK9) modulates the circulating levels of low-density lipoprotein cholesterol (LDL-C). Consequently, PCSK9 inhibition, at any level, from the

E Enrico Mario Alessandro Fassi

Cornea Arcus and Dyslipidemia in Unrelated Adults With Monoallelic Germline Variants in the Glucokinase Regulator Gene

Clin Med Insights Endocrinol Diabetes. 2026 May 6;19:11795514261441435. doi: 10.1177/11795514261441435. eCollection 2026.ABSTRACTVariants in the Glucokinase Regulator (GCKR) gene are increasingly being detected with growing applications of genomic sequencing technologies. Despite the crucial roles o

B Bukola A Olarewaju

Long-term LDL cholesterol burden and stroke: mechanistic insights and emerging strategies for personalized lipid management

Front Neurol. 2026 Apr 28;17:1836134. doi: 10.3389/fneur.2026.1836134. eCollection 2026.ABSTRACTLow-density lipoprotein cholesterol (LDL-C) is a causal and modifiable driver of atherosclerotic cardiovascular disease and an important contributor to atherosclerotic ischemic stroke. Increasing evidence

Z Zhuanfang Li

Subtype-specific effects of clonal hematopoiesis on cerebrovascular and cardiometabolic disease risk

Front Neurol. 2026 Apr 28;17:1830391. doi: 10.3389/fneur.2026.1830391. eCollection 2026.ABSTRACTBACKGROUND: Cerebrovascular and related cardiometabolic diseases frequently cluster in aging populations characterized by metabolic dysfunction and chronic inflammation. Clonal hematopoiesis of indetermin

W Wenqiang Zhu

Early Outcomes After Total Arch Replacement With Frozen Elephant Trunk in Elderly Patients With Acute Type A Aortic Dissection

Aging Med (Milton). 2026 Apr 30;9:111-128. doi: 10.1002/agm2.70076. eCollection 2026 Apr.ABSTRACTOBJECTIVE: The clinical efficacy and early outcomes of total arch replacement with frozen elephant trunk (TAR+FET) in elderly patients presenting with acute type A aortic dissection (ATAAD) remain incomp

J Jiajun Liang

Convergent Immune-Coagulation Programs Underlie Gastrointestinal Bleeding Risk in Portal Vein Tumor Thrombosis-Associated Hepatocellular Carcinoma and Portal Hypertension

Hum Mutat. 2026 May 12;2026:7210691. doi: 10.1155/humu/7210691. eCollection 2026.ABSTRACTBACKGROUND: Portal vein tumor thrombosis (PVTT) and portal hypertension are major contributors to gastrointestinal bleeding in hepatocellular carcinoma (HCC), yet the molecular programs linking vascular patholog

X Xu Rutao

Effect of Short-Term Vitamin D3 Supplementation on Blood Pressure in Patients With Hypertension: A Pilot Study From a Tertiary Care Hospital

Cureus. 2026 Apr 12;18(4):e106876. doi: 10.7759/cureus.106876. eCollection 2026 Apr.ABSTRACTBackground Essential hypertension is a major risk factor for cardiovascular disease. Emerging evidence suggests that vitamin D deficiency may contribute to the development of essential hypertension through me

S Santhoshakumari T M J

Thyroid Storm Presenting With Neurological, Obstetric, and Cardiovascular Features: A Case Series

Cureus. 2026 Apr 11;18(4):e106859. doi: 10.7759/cureus.106859. eCollection 2026 Apr.ABSTRACTThyroid storm is a rare but life-threatening endocrine emergency that can present with a wide range of clinical manifestations, which may delay diagnosis, particularly in atypical cases. We present a case ser

D Daniel Balderrama

Plasma Extracellular Vesicle Surface Marker Profiling Reveals Immune Cell-Associated Mitochondrial Membrane Potential Alterations in Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Open Forum Infect Dis. 2026 May 12;13(5):ofag209. doi: 10.1093/ofid/ofag209. eCollection 2026 May.ABSTRACTBACKGROUND: Long COVID (LC) is characterized by symptoms persisting at least 3 months after SARS-CoV-2 infection and affecting multiple organ systems. Diagnosis relies on subjective criteria wit

G Gentaro Ikeda

A Qualitative Study on the Psychological Experience of Lung Cancer Patients During the Perioperative Period

Cancer Manag Res. 2026 May 8;18:589437. doi: 10.2147/CMAR.S589437. eCollection 2026.ABSTRACTPURPOSE: To explore the psychological changes experienced by lung cancer patients throughout the perioperative period and to provide a reference for nurses in developing targeted psychological care plans.PATI

X Xin-Ning Lei

Periodontitis and cardiovascular diseases: bridging the gap through mitochondrial dysfunction

Front Oral Health. 2026 Apr 28;7:1791758. doi: 10.3389/froh.2026.1791758. eCollection 2026.ABSTRACTEpidemiological studies have reported a distinct link between periodontitis and cardiovascular diseases (CVD). However, the underlying mechanisms-except for systemic inflammation-are still poorly under

W Weiquan Li

Serum adipocyte fatty acid-binding protein is associated with impaired endothelial function in nondialysis chronic kidney disease

Tzu Chi Med J. 2026 Jan 12;38(2):203-209. doi: 10.4103/tcmj.tcmj_173_25. eCollection 2026 Apr-Jun.ABSTRACTOBJECTIVES: Adipocyte fatty acid-binding protein (A-FABP) has been implicated in atherosclerosis, and endothelial dysfunction is a critical contributor to cardiovascular outcomes in chronic kidn

T Teoh Ling Lun

Recurrent allergic reactions to unrecognized chlorhexidine exposure leading to pulseless electrical activity: a case report

Nagoya J Med Sci. 2026 Feb;88(1):149-156. doi: 10.18999/nagjms.88.1.149.ABSTRACTChlorhexidine applied to the skin during catheter insertion can cause allergic reactions; however, its potential to cause perioperative anaphylaxis is often overlooked. Herein, we report a case of recurrent allergic reac

A Akari Kawaguchi

Recurrent Takotsubo Syndrome and Pulmonary Embolism Revealing a Pheochromocytoma: A Diagnostic Pitfall

Cureus. 2026 May 12;18(5):e108731. doi: 10.7759/cureus.108731. eCollection 2026 May.ABSTRACTStress cardiomyopathy (Takotsubo syndrome or TTS) is an acute and reversible left ventricular dysfunction typically triggered by emotional or physical stress. Although most cases are idiopathic, secondary cau

A Alfakihi Ahmed Said IsmaIl

Negative impact of reduced exocrine pancreatic function on sarcopenia risk in the asymptomatic general population

Front Nutr. 2026 Apr 28;13:1830761. doi: 10.3389/fnut.2026.1830761. eCollection 2026.ABSTRACTBACKGROUND: In patients with pancreatic disease, exocrine insufficiency facilitates sarcopenia. Here, we investigated whether impaired exocrine function in the asymptomatic general population is also associa

M Mats L Wiese

Plant-based diets for human health with implications for cardiometabolic health, gut microbiome, and nutritional adequacy

Front Nutr. 2026 Apr 28;13:1830797. doi: 10.3389/fnut.2026.1830797. eCollection 2026.ABSTRACTPlant-based diets have gained considerable interest in recent times due to their perceived health and environmental benefits. However, the term "plant-based diet" refers to a broad range of diets with a wide

M Mansour Alblaji