Identification and validation of cholesterol homeostasis and NK cell-associated predictive and therapeutic models for Coronary atherosclerotic heart disease patients with ST-elevated myocardial infarction: Insights from artificial intelligence and multi-omics

Comput Biol Chem. 2026 May 14;124(Pt 1):109103. doi: 10.1016/j.compbiolchem.2026.109103. Online ahead of print.ABSTRACTOBJECTIVE: Dysregulation of Cholesterol homeostasis(CH) and NK cells proportion can increase risk of ST-Elevated Myocardial Infarction(STEMI) for Coronary atherosclerotic heart dise

X Xuemei Chen

Sodium Disorders in Multiple Myeloma: Beyond Pseudohyponatremia to Clinical Pitfalls and Mechanistic Insights

G Ital Nefrol. 2026 Apr 30;43(2):2026-vol2. doi: 10.69097/43-01-2026-08.ABSTRACTHyponatremia is a relatively frequent finding in multiple myeloma (MM) and may result from either pseudohyponatremia, due to marked hyperproteinemia, or true hyponatremia from genuine sodium-water imbalance. Differentiat

E Elena Tanzarella

Acute Kidney Injury and Early Diagnostic Biomarkers: A Narrative Literature Review

G Ital Nefrol. 2026 Apr 30;43(2):2026-vol2. doi: 10.69097/43-02-2026-07.ABSTRACTIntroduction. Acute kidney injury (AKI) is a serious entity characterized by sudden impairment of renal function in hospitalized patients, particularly in the intensive care unit, resulting in high morbidity and mortalit

G Georgios Gerasopoulos

Prevalence of direct oral anticoagulant users among patients with acute ischemic stroke

Orv Hetil. 2026 May 17;167(20):779-783. doi: 10.1556/650.2026.33544. Print 2026 May 17.ABSTRACTINTRODUCTION: Despite the use of direct oral anticoagulants (DOACs), acute ischemic stroke can occur for several reasons. According to international data, 20% of patients with acute ischemic stroke take DO

B Balázs Fazekas

Novelty to necessity: large language models in clinical practice-a call to action for physicians

Intern Emerg Med. 2026 May 17. doi: 10.1007/s11739-026-04393-z. Online ahead of print.ABSTRACTLarge language models (LLMs) represent a rapidly advancing subset of artificial intelligence with significant potential to augment clinical practice. These tools can assist in literature synthesis, document

V Vittorio Beltrani

Heart failure in adults with congenital heart disease: the role of sodium-glucose cotransporter 2 inhibitors

Curr Opin Cardiol. 2026 May 18. doi: 10.1097/HCO.0000000000001311. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Heart failure (HF) is the leading cause of morbidity and mortality in adults with congenital heart disease (ACHD), yet evidence-based pharmacological options remain limited. Sodium-glu

M Maria Savvidi

Imaging Biomarkers for Cardiometabolic Risk Stratification in MASLD: Incremental Value of CAC, EAT, CAP, and LSM Beyond Clinical Scores

Br J Radiol. 2026 May 15:tqag112. doi: 10.1093/bjr/tqag112. Online ahead of print.ABSTRACTOBJECTIVES: To systematically synthesize evidence on the association between metabolic dysfunction-associated steatotic liver disease (MASLD) and imaging biomarkers of subclinical atherosclerosis and hepatic st

J Jiaxin Zhong

Comparison of anthracycline plus platinum versus other platinum-based regimens as first-line chemotherapy for untreated thymoma: A retrospective cohort study (NEJ023B)

Lung Cancer. 2026 May 12;217:109456. doi: 10.1016/j.lungcan.2026.109456. Online ahead of print.ABSTRACTBACKGROUND: Optimal management of advanced thymoma remains uncertain. We compared the efficacy of first-line platinum-anthracycline chemotherapy with other platinum-based regimens in a large Japane

G Go Saito

Elastance as a determinant of the effect of prone positioning on mortality in acute respiratory distress syndrome: a post hoc analysis of the PROSEVA trial

Crit Care. 2026 May 16. doi: 10.1186/s13054-026-06060-3. Online ahead of print.ABSTRACTBACKGROUND: Patient factors determining the benefit of prone positioning remain uncertain, resulting in the maneuver being applied indiscriminately among those with moderate-severe ARDS. We aimed to assess if base

A Ann A Zalucky

Targeting mitochondrial fission-autophagy axis in rheumatoid arthritis: leflunomide promote apoptosis of fibroblast-like synoviocytes

Arthritis Res Ther. 2026 May 16. doi: 10.1186/s13075-026-03828-4. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and joint destruction, driven by aberrantly activated fibroblast-like synoviocytes (RA-FLS). Mitochondrial d

X Xiaoxue Wang

Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020

Cardiovasc Diabetol. 2026 May 16. doi: 10.1186/s12933-026-03206-z. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3 represent a critical window for preventing progression to overt cardiovascular disease (CVD). Insulin resistance (IR) is central to C

S Shu-Shu Han

Multi‑omics identification of MSI2 as a super-enhancer‑driven vulnerability in MYCN‑amplified neuroblastoma

J Transl Med. 2026 May 16. doi: 10.1186/s12967-026-08296-7. Online ahead of print.ABSTRACTBACKGROUND: Neuroblastoma (NB) is the most common extracranial solid tumor in children and is characterized by marked clinical heterogeneity and poor prognosis. MYCN amplification drives NB tumorigenesis throug

X Xi Zhang

Early postoperative treprostinil in for severe pulmonary arterial hypertension in a high-risk pediatric patient with complete atrioventricular septal defect: a case report

BMC Cardiovasc Disord. 2026 May 16. doi: 10.1186/s12872-026-05954-y. Online ahead of print.ABSTRACTBACKGROUND: Perioperative management of pediatric patients with congenital heart disease (CHD) and severe pulmonary arterial hypertension (PAH) remains challenging because of limited evidence-based gui

S Sha Zhao

Diagnostic value of miR-148b-3p in left ventricular hypertrophy patients with hypertension

BMC Cardiovasc Disord. 2026 May 16. doi: 10.1186/s12872-026-05939-x. Online ahead of print.ABSTRACTBACKGROUND: To explore the expression characteristics, diagnostic value, and regulatory role of miR-148b-3p in hypertensive patients with left ventricular hypertrophy (LVH), providing preliminary evide

K Kai Xie

Predictors of metabolic syndrome among type II diabetic patients visiting public hospitals in Sidama Region, Ethiopia: unmatched case control study

BMC Cardiovasc Disord. 2026 May 16. doi: 10.1186/s12872-026-05982-8. Online ahead of print.ABSTRACTINTRODUCTION: Metabolic syndrome (MetS) is a series of health conditions, including insulin resistance, abdominal obesity, hypertension, and dyslipidemia. In diabetic patients, MetS elevates the risks

B Bereket Sisay Gebremichael

Endovascular thrombectomy versus best medical therapy for acute vertebrobasilar artery occlusion in patients with low NIHSS scores: a meta-analysis

Ann Med. 2026 Dec;58(1):2673631. doi: 10.1080/07853890.2026.2673631. Epub 2026 May 16.ABSTRACTOBJECTIVE: The efficacy of endovascular thrombectomy (EVT) for acute vertebrobasilar artery occlusion (VBAO) presenting with mild symptoms (National Institutes of Health Stroke Scale [NIHSS] score ≤10) rema

Y Yaqin Qin

Coronary Artery Disease in Masters Athletes: A Systematic Review

Sports Med. 2026 May 16. doi: 10.1007/s40279-026-02429-0. Online ahead of print.ABSTRACTBACKGROUND: Despite undertaking large volumes of structured exercise training, evidence suggests that masters athletes (MAs) remain susceptible to coronary artery disease (CAD). This review evaluated the prevalen

S Shaqira Gill

Impact of age on clinical outcomes after endovascular therapy for large ischemic stroke

J Neurol. 2026 May 16;273(6):317. doi: 10.1007/s00415-026-13844-8.ABSTRACTBACKGROUND: The impact of age on outcomes in patients with large ischemic stroke [defined as Alberta Stroke Program Early Computed Tomography Score (ASPECTS) ≤ 5] remains unclear. This study aimed to explore the effect of age

H Haoxuan Zhu

Prognostic value of pretest probability of heart failure with preserved ejection fraction in patients with coronary artery disease: an insight from the CLIDAS-PCI database

Cardiovasc Interv Ther. 2026 May 16. doi: 10.1007/s12928-026-01286-y. Online ahead of print.ABSTRACTCoronary artery disease (CAD) is a major risk factor for the development of heart failure (HF) with preserved ejection fraction (HFpEF) and is associated with increased mortality. However, an optimal

T Tomoaki Nishikawa

Kullback-Leibler divergence in feature selection: a methodology for improved detection of heart valve disorders

Phys Eng Sci Med. 2026 May 16. doi: 10.1007/s13246-026-01737-z. Online ahead of print.ABSTRACTDimensionality reduction is crucial for the effective management of high-dimensional datasets, particularly in the healthcare industry. Feature selection identifies the most relevant attributes, reducing co

V V H Preetha

Drug-coated balloon angioplasty in coronary artery disease: state of the art review

NPJ Cardiovasc Health. 2026 May 16. doi: 10.1038/s44325-026-00132-7. Online ahead of print.ABSTRACTDrug-coated balloons (DCBs) provide a "leave-nothing-behind" revascularization strategy, delivering antiproliferative therapy without permanent implants. This review presents evidence on DCB performanc

P Panagiotis Theofilis

Design and implementation of a hybrid machine learning framework for predicting heart rate status

Sci Rep. 2026 May 16. doi: 10.1038/s41598-026-53054-w. Online ahead of print.ABSTRACTReal-time accurate evaluation of heart rate status during physical activity is a critical requirement in physiological analysis, performance enhancement, and early warning systems for cardiovascular diseases. In thi

M Mahsa Emami

Tolerability and efficacy of full-body head-up tilt sleeping in Parkinson's disease and multiple system atrophy

NPJ Parkinsons Dis. 2026 May 16. doi: 10.1038/s41531-026-01359-y. Online ahead of print.ABSTRACTOrthostatic hypotension (OH) and the co-existence with supine hypertension (SH) are debilitating consequences of autonomic failure in Parkinson's disease (PD) and multiple system atrophy (MSA). Head-up ti

A Amber H van der Stam

An era of precision: Emerging, research, and adjunct radiotracers for nuclear imaging of cardiac amyloidosis

J Nucl Cardiol. 2026 May;59S:102726. doi: 10.1016/j.nuclcard.2026.102726. Epub 2026 May 15.ABSTRACTCardiac amyloidosis (CA) has rapidly transitioned from an underrecognized cause of heart failure to a treatable protein-misfolding cardiomyopathy, driven by advances in transthyretin (TTR) stabilizatio

J Jonathan S Wall