PLOS Digit Health. 2026 Oct 1;5(10):e0001763. doi: 10.1371/journal.pdig.0001763. eCollection 2026 Oct.ABSTRACTMRI-detected extramural vascular invasion (mrEMVI) is an important prognostic biomarker in rectal cancer, reflecting tumor invasiveness and metastatic potential. To address the subjectivity
PLoS One. 2026 Oct 1;21(10):e0359660. doi: 10.1371/journal.pone.0359660. eCollection 2026.ABSTRACTTicagrelor, a commonly used antiplatelet medication, has been found to exhibit considerable inter-individual pharmacodynamic variability. Recent studies have revealed a close relationship between pharma
J Vet Intern Med. 2026 Sep 1;40(5):aalag224. doi: 10.1093/jvimsj/aalag224.ABSTRACTBACKGROUND: Consensus is lacking on which endocardial borders to include when measuring left ventricular wall thickness (LVWT) in cats.HYPOTHESIS/OBJECTIVES: The number of endocardial borders included can influence whe
Int Wound J. 2026 Oct;23(10):e71058. doi: 10.1111/iwj.71058.ABSTRACTPlacental-derived cellular, acellular, and matrix-like products (CAMPs) are widely used as adjuncts to standard care for diabetic foot ulcers (DFUs), but trials differ in product class, comparator, and healing window. We estimated t
J Clin Invest. 2026 Oct 1;136(19):e197609. doi: 10.1172/JCI197609. eCollection 2026 Oct 1.ABSTRACTVascular endothelial cells (ECs) encode a homeostatic fluid shear stress (FSS) set point that is essential for vascular stability. Deviations above or below this threshold trigger adaptive remodeling to
J Clin Invest. 2026 Oct 1;136(19):e210364. doi: 10.1172/JCI210364. eCollection 2026 Oct 1.ABSTRACTHereditary hemorrhagic telangiectasia (HHT) is characterized by fragile, enlarged vessels with arteriovenous connections, which can form arteriovenous malformations (AVMs) that are prone to rupture. It
J Clin Invest. 2026 Oct 1;136(19):e209668. doi: 10.1172/JCI209668. eCollection 2026 Oct 1.ABSTRACTPreclinical drug development has long relied on animal models to predict safety and efficacy before agents enter human trials, despite critical differences between human and animal model physiology. The
J Vasc Surg Cases Innov Tech. 2026 Aug 24;12(6):102471. doi: 10.1016/j.jvscit.2026.102471. eCollection 2026 Dec.ABSTRACTA 55-year-old man with serologically confirmed tertiary syphilis had an asymptomatic 70 mm bilobed thoracoabdominal aortic aneurysm with two contiguous saccular components, severe
Respirol Case Rep. 2026 Sep 30;14(10):e70778. doi: 10.1002/rcr2.70778. eCollection 2026 Oct.ABSTRACTWe report a 62-year-old man with myelodysplastic syndrome on immunosuppressive therapy who presented with right lung consolidation and neutropenia. Despite broad antimicrobial therapy for presumed pne
Lancet Reg Health Eur. 2026 Aug 30;70:101846. doi: 10.1016/j.lanepe.2026.101846. eCollection 2026 Nov.ABSTRACTBACKGROUND: Central Europe carries a substantial global burden of ischaemic heart disease (IHD). We aimed to quantify sex-specific differences in IHD case-fatality across 13 Central European
Cureus. 2026 Aug 31;18(8):e115481. doi: 10.7759/cureus.115481. eCollection 2026 Aug.ABSTRACTA drug-coated balloon (DCB) strategy has become an established option for de novo coronary lesions, offering the advantage of avoiding permanent implants. However, very long-term vascular changes after stentl
Risk Manag Healthc Policy. 2026 Sep 26;19:618968. doi: 10.2147/RMHP.S618968. eCollection 2026.ABSTRACTArtificial intelligence (AI) is reshaping kidney care by integrating electronic health records (EHRs), imaging, digital pathology, genomics, wearable biosensors, and longitudinal physiologic data in
Eur Heart J Case Rep. 2026 Sep 19;10(10):ytag714. doi: 10.1093/ehjcr/ytag714. eCollection 2026 Oct.ABSTRACTBACKGROUND: ST-segment elevation myocardial infarction (STEMI) in young patients without traditional cardiovascular risk factors requires evaluation beyond atherosclerotic disease. Inherited th
Kidney Med. 2026 Aug 3;8(10):101484. doi: 10.1016/j.xkme.2026.101484. eCollection 2026 Oct.ABSTRACTRATIONALE & OBJECTIVE: Chronic kidney disease (CKD) is associated with substantial economic burden. Early identification of high-risk patients with CKD can facilitate timely intervention and reduce CKD
Cureus. 2026 Aug 31;18(8):e115500. doi: 10.7759/cureus.115500. eCollection 2026 Aug.ABSTRACTMarfan syndrome (MFS) is an autosomal dominant multisystemic connective tissue disorder caused by pathogenic variants in the FBN1 gene and characterized by cardiovascular, ocular, and musculoskeletal manifest
Front Immunol. 2026 Sep 16;17:1924972. doi: 10.3389/fimmu.2026.1924972. eCollection 2026.ABSTRACT[This corrects the article DOI: 10.3389/fimmu.2026.1818835.].PMID:42820009 | PMC:PMC13625761 | DOI:10.3389/fimmu.2026.1924972
MedComm (2020). 2026 Sep 30;7(10):e70956. doi: 10.1002/mco2.70956. eCollection 2026 Oct.ABSTRACTManaging hypertriglyceridemia (HTG) requires more than lowering triglyceride (TG) levels. Two related but clinically distinct risk domains often guide management: residual atherosclerotic cardiovascular d
Chem Biomed Imaging. 2026 Apr 21;4(9):1933-1961. doi: 10.1021/cbmi.5c00284. eCollection 2026 Sep 28.ABSTRACTAtherosclerosis (AS) poses major challenges for precise diagnosis and targeted therapy due to its complex inflammatory and oxidative plaque microenvironment. This review begins by dissecting t
Eur Heart J Case Rep. 2026 Sep 26;10(10):ytag702. doi: 10.1093/ehjcr/ytag702. eCollection 2026 Oct.ABSTRACTBACKGROUND: Emergency pericardiocentesis represents a life-saving intervention in patients with acute cardiac tamponade. During complex percutaneous coronary intervention (PCI), abrupt haemodyn
Front Cardiovasc Med. 2026 Sep 16;13:1926629. doi: 10.3389/fcvm.2026.1926629. eCollection 2026.ABSTRACTGlucagon-like peptide-1 receptor agonists (GLP-1RAs) and the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist tirzepatide have expanded from glucose-lowering therapy i
ACS Omega. 2026 Jun 9;11(34):50769-50777. doi: 10.1021/acsomega.6c00607. eCollection 2026 Sep 1.ABSTRACTCardiovascular disease (CVD) is the leading cause of death worldwide. After acute myocardial infarction (AMI), the adult human heart has very limited regenerative capacities, and the electrical pr
Front Cardiovasc Med. 2026 Sep 16;13:1905691. doi: 10.3389/fcvm.2026.1905691. eCollection 2026.ABSTRACTBACKGROUND: Coronary microvascular disease (CMVD) is an emerging concern under high-altitude hypoxia, but data on modifiable correlates are scarce. Serum calcium regulates vascular tone and coagula
Front Endocrinol (Lausanne). 2026 Sep 16;17:1885104. doi: 10.3389/fendo.2026.1885104. eCollection 2026.ABSTRACTGrowth differentiation factor 15 (GDF15) is a stress responsive cytokine belonging to the transforming growth factor-β (TGF-β) superfamily, serving as a sentinel of metabolic integrity. Its
Front Endocrinol (Lausanne). 2026 Sep 16;16:1608456. doi: 10.3389/fendo.2025.1608456. eCollection 2025.ABSTRACTOBJECTIVE: To systematically evaluate the clinical effect of intravitreal ranibizumab (IVR) and laser photocoagulation on diabetic macular edema (DME).METHOD: A systematic search was conduc
