Prevalence of Left Ventricular Diastolic Dysfunction and Prognostic Value in Septic Shock Patients According to Different Guidelines: Comparison Between Contemporary Cardiological Algorithms and Simplified Approaches

Echocardiography. 2026 Sep;43(9):e70638. doi: 10.1111/echo.70638.ABSTRACTBACKGROUND: Diagnosis of left ventricular diastolic dysfunction (LVDD) in the context of septic shock is challenging. We aimed to compare different algorithms applied to septic patients.METHODS: Secondary analysis of a prospect

F Filipe A Gonzalez

Identification of a Lactylation-Related Gene Signature and Candidate Biomarkers for Dilated Cardiomyopathy

J Cell Mol Med. 2026 Sep;30(18):e71379. doi: 10.1111/jcmm.71379.ABSTRACTDilated cardiomyopathy (DCM) is a leading cause of heart failure. Due to its complex pathogenesis, effective treatment strategies remain limited. Therefore, it is particularly important to identify novel candidate biomarkers fro

X Xiaoyan Zhi

Current challenges in diagnosing homozygous familial hypercholesterolemia: Insights from the historical evolution of diagnostic criteria

J Clin Lipidol. 2026 Sep 3:S1933-2874(26)00499-X. doi: 10.1016/j.jacl.2026.08.024. Online ahead of print.ABSTRACTBACKGROUND: Homozygous familial hypercholesterolemia (HoFH) is a rare disease characterized by dysfunctional low-density lipoprotein receptors (LDLR) and markedly elevated low-density lip

D Daniel Gaudet

From evidence to action: Why employers must address prolonged sitting in modern workplaces

Public Health. 2026 Sep 26:106484. doi: 10.1016/j.puhe.2026.106484. Online ahead of print.ABSTRACTThe global workforce has undergone substantial transformation in recent decades, with technological advances, digitalization, remote working, and expanding administrative demands contributing to an incr

M Muslim Abbas Syed

One million exomes identify FNIP1 as a metabolic brake

Trends Genet. 2026 Sep 25:S0168-9525(26)00223-4. doi: 10.1016/j.tig.2026.09.003. Online ahead of print.ABSTRACTExome sequencing of more than 1 million people uncovered dozens of genes linked to the biomarker of the body's energy state (Hindy et al.). Rare loss-of-function variants in FNIP1, a suppre

N Nobuyuki Enzan

Comparison of four clinical risk prediction models for the diagnosis of giant cell arteritis: results from the ongoing PREDICT-GCA study

RMD Open. 2026 Sep 25;12(3):e006932. doi: 10.1136/rmdopen-2026-006932.ABSTRACTBACKGROUND: The potential role of structured clinical pretest probability assessment in the diagnostic workup of giant cell arteritis (GCA) is not well defined.PATIENTS AND METHODS: We applied four clinical prediction rule

L Lukas-Casper Thielmann

Geographic variation in the diagnosis of cardiomyopathies in a universal healthcare system: a nationwide study of hypertrophic and arrhythmogenic right ventricular cardiomyopathy in Denmark

Open Heart. 2026 Sep 25;13(2):e004493. doi: 10.1136/openhrt-2026-004493.ABSTRACTBACKGROUND: In Denmark, hypertrophic cardiomyopathy (HCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC) are primarily diagnosed and managed in specialised inherited cardiac disease clinics, making them suita

P Priya Bhardwaj

Longitudinal phenotyping of heart failure with preserved ejection fraction identifies early- and end-stage disease states

Open Heart. 2026 Sep 25;13(2):e004351. doi: 10.1136/openhrt-2026-004351.ABSTRACTBACKGROUND AND AIMS: Heart failure with preserved ejection fraction (HFpEF) phenotypes have been characterised as static entities in trial populations yet their temporal dynamics remain unexplored in routine clinical pra

S Samuel Brown

GRB2 Affects Post-Myocardial Infarction Heart Failure by Regulating the TLR4/NF-κB Pathway-Mediated M1 Macrophage Polarization

Ann Clin Lab Sci. 2026 Jul;56(4):456-466.ABSTRACTOBJECTIVE: Myocardial infarction (MI) and MI-related heart failure (HF) continue to represent predominant causes of disability and death globally. This study aimed to explore the specific involvement of growth factor receptor-bound protein 2 (GRB2) in

Y Yu Wang

Circ_0001490/miR-330-3p/RCAN1 Signaling Defines a ceRNA Network Associated with Rheumatic Heart Disease Progression

Ann Clin Lab Sci. 2026 Jul;56(4):420-431.ABSTRACTOBJECTIVE: Circular RNAs (circRNAs) have been implicated in several cardiovascular disorders, yet their regulatory roles in rheumatic heart disease (RHD) and related molecular pathways remain poorly defined.METHODS: Human heart valve interstitial cell

X Xiaoliang Chen

Study on blueberries, protein and exercise for improving frailty and cardiovascular disease (STRONG): protocol for a parallel-group randomised controlled superiority trial in older Nova Scotians

BMJ Open. 2026 Sep 25;16(9):e114286. doi: 10.1136/bmjopen-2025-114286.ABSTRACTINTRODUCTION: As frailty and cardiovascular disease are closely linked, lifestyle interventions to reduce frailty could improve cardiovascular health in at-risk individuals. Previous clinical trials have shown that exercis

L Leah E Cahill

Co-creating a patient-driven digital monitoring agenda for thoracic aortic disease: a multiphase qualitative study

BMJ Open. 2026 Sep 25;16(9):e121086. doi: 10.1136/bmjopen-2026-121086.ABSTRACTOBJECTIVES: To identify, through structured co-creation with patients across the thoracic aortic disease (TAD) spectrum, which domains of between-visit monitoring patients themselves consider meaningful and to translate th

N Nimrat Grewal

Data that matter: what outcomes matter to patients with congenital heart disease and their carers and which should be routinely measured? A qualitative asynchronous online discussion forum

BMJ Open. 2026 Sep 25;16(9):e111466. doi: 10.1136/bmjopen-2025-111466.ABSTRACTOBJECTIVES: We wanted, as part of a wider study, to elicit perspectives of patients with congenital heart disease (CHD) and/or their parents/carers about which outcomes of CHD and/or cardiac surgery matter and what should

J Jo Wray

The New Landscape of Cystic Fibrosis in the Era of Highly Effective Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapy

J Mother Child. 2026 Sep 25;30(1):180-186. doi: 10.34763/jmotherandchild.20263001.d-26-00011. eCollection 2026 Jan 1.ABSTRACTBACKGROUND: For many years, the management of cystic fibrosis has had a personalised character. We have now entered an era of therapy based on a patient's specific genotype. C

A Anna Wołkowicz

The Post-ROSC ECG: Morphological Spectrum of Non-ST-Elevation Occlusion and Prognostic Markers After Cardiac Arrest

Resuscitation. 2026 Sep 25:111334. doi: 10.1016/j.resuscitation.2026.111334. Online ahead of print.ABSTRACTBACKGROUND: Occlusive myocardial infarction (OMI) frequently presents without ST-elevation (NST-OMI) after return of spontaneous circulation (ROSC), complicating triage decisions. Aim of this s

C Claudio Silwanis

Sex Differences Following Cardiac Arrest: A Conceptual Framework for Mechanisms and Translational Targets

Resuscitation. 2026 Sep 25:111336. doi: 10.1016/j.resuscitation.2026.111336. Online ahead of print.ABSTRACTBiological sex is increasingly recognized as a fundamental variable in cardiovascular and cerebrovascular disease, yet its integration into our understanding of post-cardiac arrest brain injury

N N Catie Futhey

Berberine induces pleiotropic beneficial effects via hormesis

Pharmacol Res. 2026 Sep 25:109638. doi: 10.1016/j.phrs.2026.109638. Online ahead of print.ABSTRACTBerberine is a phytochemical that has been shown to prevent a spectrum of serious ailments, to slow aging, and to extend lifespans and health spans of animals, demonstrating its pleiotropic effectivenes

E Edward J Calabrese

The regulatory and therapeutic potential of transposable elements in cancer and inflammatory diseases

Pharmacol Ther. 2026 Sep 25:109128. doi: 10.1016/j.pharmthera.2026.109128. Online ahead of print.ABSTRACTTransposable elements (TEs), commonly known as "jumping genes," constitute nearly half of the human genome and are increasingly recognized as important regulators of gene expression, chromatin or

K Keman Xu

The rhythm of pressure: Circadian disruption and chronotherapy

Pharmacol Ther. 2026 Sep 25:109127. doi: 10.1016/j.pharmthera.2026.109127. Online ahead of print.ABSTRACTDisruption of circadian blood pressure (BP) rhythm is a key pathophysiological feature and an important marker of cardiovascular risk. Ambulatory BP monitoring, the gold standard for assessing BP

K Kan Gao

Angiography-derived index of microcirculatory resistance in older patients with acute coronary syndrome undergoing percutaneous coronary intervention

CONCLUSION: Older NSTE-ACS patients with high post-PCI IMR(angio) have worse long-term clinical outcomes. In this clinical setting, post-PCI IMR(angio), together with conventional risk factors and angiographic variables, may help identifying a higher-risk phenotype.Int J Cardiol. 2026 Sep 25:134945.

M Martina Magistri

Contrast-Associated Acute Kidney Injury: Comprehensive Review of Risk Factors, Pathophysiology, Definition and Management

Mayo Clin Proc. 2026 Sep 25:S0025-6196(26)18762-X. doi: 10.1016/j.mayocp.2026.09.012. Online ahead of print.ABSTRACTContrast-associated acute kidney injury (CA-AKI) remains an important clinical concern, especially as percutaneous coronary interventions (PCI) are being increasingly performed. This r

F Frederick Berro Rivera

Mechanical Characterization and Ex Vivo Evaluation of a Novel Constraining Device for Safe Endovascular Endograft Explantation

Ann Vasc Surg. 2026 Sep 25:S0890-5096(26)00664-3. doi: 10.1016/j.avsg.2026.09.014. Online ahead of print.ABSTRACTOBJECTIVE: Open surgical conversion after EVAR is morbid and performed without disease-specific instruments. We evaluated the feasibility, and mechanical characteristics of the EVAx, a no

R Richard Longfei Li

The endothelin system: a potential target for the treatment of type 2 diabetes mellitus and associated cardiometabolic complications

Drug Discov Today. 2026 Sep 25:104815. doi: 10.1016/j.drudis.2026.104815. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR), metabolic dysfunction, and cardiovascular (CV) and renal complications. Endothelin-1 (ET-1) receptors are widely expres

M Md Moklesur Rahman Sarker

Developing and validating intrinsic capacity scores in early adulthood and midlife: 15-year follow-up from the Northern Finland Birth Cohort 1966

Exp Gerontol. 2026 Sep 25:113340. doi: 10.1016/j.exger.2026.113340. Online ahead of print.ABSTRACTBACKGROUND: Intrinsic capacity (IC) - the aggregate of physical and mental capacities - has been studied in older adults, but research on its profile and prognostic value earlier in adulthood is scarce.

L Leah Hillari