Therapeutic Remodeling of the Gut Microbiome as a Strategy to Restore Immune Tolerance in Autoimmunity

Microbiologyopen. 2026 Apr;15(2):e70294. doi: 10.1002/mbo3.70294.ABSTRACTAutoimmune diseases happen when the immune system, which is supposed to defend the body from infections and other harmful things, starts to attack the body's own cells by mistake. In the last few years, they seem to be getting

B Behshad Boroumand

Genetic analysis and clinical phenotype of pulmonary arterial hypertension in an Algerian population

Ann Saudi Med. 2026 Mar-Apr;46(2):111-120. doi: 10.5144/0256-4947.2026.111. Epub 2026 Apr 16.ABSTRACTBACKGROUND: Pulmonary arterial hypertension (PAH) involves progressive obstruction of small pulmonary vessels due to vascular remodeling. Although the genetic architecture of PAH is increasingly unde

A Amel Wafa Berkane

Associations of Neprilysin and Its Coding Gene Variation With Hypertension in Chinese Adults

J Clin Hypertens (Greenwich). 2026 Apr;28(4):e70260. doi: 10.1111/jch.70260.ABSTRACTNeprilysin (NEP) degrades several vasoactive peptides and may contribute to blood pressure maintenance. This study aims to examine the associations between serum NEP levels and variants at its coding gene and hyperte

J Junting Hu

Divergent Trends in Stroke Subtype Mortality Attributable to High Systolic Blood Pressure in China, 1990 to 2021: An Age-Period-Cohort Analysis and Projection

Med Sci Monit. 2026 Apr 19;32:e951794. doi: 10.12659/MSM.951794.ABSTRACTBACKGROUND High systolic blood pressure (HSBP) is a major contributor to stroke mortality in China. This study analyzed trends in HSBP-attributable stroke mortality from 1990 to 2021 to elucidate the effects of age, period, and

Y Yaoyao Li

Polypharmacy and Drug-Drug Interactions in Long-Term Care Facilities residents: findings from the Italian Prescription Day Project

J Gerontol A Biol Sci Med Sci. 2026 Apr 17:glag104. doi: 10.1093/gerona/glag104. Online ahead of print.ABSTRACTBACKGROUND: Medication prescribing in Long-Term Care Facilities (LTCFs) is characterised by widespread polypharmacy and frequent exposure to potentially clinically relevant drug-drug intera

A Alba Malara

International consensus on adolescent metabolic health: prevention of obesity and type 2 diabetes

No abstractDiabetol Metab Syndr. 2026 Apr 18. doi: 10.1186/s13098-026-02142-y. Online ahead of print.NO ABSTRACTPMID:42001194 | DOI:10.1186/s13098-026-02142-y

I Inass Shaltout

MRI-based clinical-radiologic model to predict the efficacy and prognosis of interventional with systemic therapy in advanced hepatocellular carcinoma: a multicenter study

No abstractJ Transl Med. 2026 Apr 18. doi: 10.1186/s12967-026-08166-2. Online ahead of print.NO ABSTRACTPMID:42001158 | DOI:10.1186/s12967-026-08166-2

X Xingrong Zheng

Impact of cardiohepatic syndrome on postoperative mortality in heart failure patients with reduced ejection fraction undergoing coronary artery bypass grafting

No abstractJ Cardiothorac Surg. 2026 Apr 18. doi: 10.1186/s13019-026-03999-w. Online ahead of print.NO ABSTRACTPMID:42001144 | DOI:10.1186/s13019-026-03999-w

Ş Şahin Yılmaz

Antibody-conjugated SIS3-loaded PLGA@polydopamine nanoparticles alleviate cardiac fibrosis by modulating Smad3 signaling in myofibroblasts

J Nanobiotechnology. 2026 Apr 18. doi: 10.1186/s12951-026-04431-0. Online ahead of print.ABSTRACTBACKGROUND: Pathological cardiac fibrosis arising from acute/chronic myocardial injury drives ventricular remodeling, functional impairment, and elevated mortality through mechanisms lacking effective th

C Cheng Chen

Machine learning prediction models for intravenous immunoglobulin resistance in Kawasaki disease: a meta-analysis

No abstractBMC Med Inform Decis Mak. 2026 Apr 18. doi: 10.1186/s12911-026-03494-1. Online ahead of print.NO ABSTRACTPMID:42001049 | DOI:10.1186/s12911-026-03494-1

C Chuankun Zhang

Endothelial JAML inhibits inflammation and atherosclerosis through TRIM25-mediated STAT1 ubiquitination

Cell Mol Biol Lett. 2026 Apr 18. doi: 10.1186/s11658-026-00924-w. Online ahead of print.ABSTRACTBACKGROUND: Atherosclerosis is a chronic inflammatory disease initiated by endothelial dysfunction. Junctional adhesion molecule-like protein (JAML) is known to regulate inflammatory responses; however, i

Q Qingmei Han

Metabolically healthy obesity is independently associated with 20-year incidence of cardiovascular disease: findings from the ATTICA cohort study (2002-2022)

Int J Obes (Lond). 2026 Apr 18. doi: 10.1038/s41366-026-02056-9. Online ahead of print.ABSTRACTBACKGROUND: Individuals with excess body weight do not share the same risk for cardiovascular disease (CVD). The phenotype of metabolically healthy obesity (MHO) has drawn the attention of the scientific c

T Theodosios D Filippatos

Tripolar versus bipolar ablation: insights into lesion growth and geometry using a novel ablation approach for therapy-refractory ventricular arrhythmias

Sci Rep. 2026 Apr 18;16(1):12739. doi: 10.1038/s41598-026-48782-y.ABSTRACTEfficacy of bipolar radiofrequency ablation (BA) is often limited by high impedance between the two ablation catheters in cases of therapy-refractory ventricular tachycardias. Tripolar ablation (TA) is a novel approach, adding

F Fabian Bahlke

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

Nat Commun. 2026 Apr 18. doi: 10.1038/s41467-026-71809-x. Online ahead of print.ABSTRACTHeart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population gene

Y Yuanzhao Cao

Serum hepcidin, iron stores, and iron availability are associated with cardiovascular health in Chinese children and adolescents: Basing on Life's Essential 8 metrics

J Trace Elem Med Biol. 2026 Apr 14;95:127875. doi: 10.1016/j.jtemb.2026.127875. Online ahead of print.ABSTRACTBACKGROUND: Iron metabolism has been associated with cardiovascular diseases, but its relationship with cardiovascular health (CVH) in childhood remains unclear. This study aimed to investig

Y Yueqin Zhou

Spermidine and spermine in elderly patients with coronary artery disease: a cross-sectional study of dietary intake and plasma and skeletal muscle concentrations

Clin Nutr. 2026 Apr 3;61:106651. doi: 10.1016/j.clnu.2026.106651. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Spermidine, a polyamine abundant in plant-based and fermented foods, has been associated with reduced cardiovascular and all-cause mortality. However, whether dietary spermidine intak

C Christian Thorup

JP2 and JCN Crosstalk Abrogate MURF1-Mediated JCN Ubiquitination and Degradation in Cardiomyocytes

JACC Basic Transl Sci. 2026 Apr 17;11(5):101534. doi: 10.1016/j.jacbts.2026.101534. Online ahead of print.ABSTRACTJunctophilin-2 (JP2) and junctin (JCN) are key proteins in maintaining calcium homeostasis in cardiomyocytes. Both are reduced in diseased hearts while overexpression of JP2 mitigates he

X Xiaoyun Ji

Prediction of post-COVID chronic fatigue syndrome using data mining and machine learning techniques in Isfahan COVID cohort study

J Infect Public Health. 2026 Apr 3;19(6):103218. doi: 10.1016/j.jiph.2026.103218. Online ahead of print.ABSTRACTBACKGROUND: Post-COVID Fatigue (PCF) is one of the most common issues people face after recovering from COVID-19. Due to the heterogeneity of clinical manifestations and the lack of object

S Shayan Nematbakhsh

Metabolomic Atlas of Cardiovascular Diseases: Mapping Shared and Specific Signatures

JACC Adv. 2026 Apr 17;5(5):102742. doi: 10.1016/j.jacadv.2026.102742. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular disease (CVD) remains the leading global cause of death. While metabolic dysregulation is central to CVD pathogenesis, the extent to which distinct clinical subtypes exhibit

J Jingjing Yang

Assessing Coronary Calcium Thresholds on Attenuation-Correction CT With Myocardial Perfusion Imaging Equating to Secondary Prevention

JACC Adv. 2026 Apr 17;5(5):102732. doi: 10.1016/j.jacadv.2026.102732. Online ahead of print.ABSTRACTBACKGROUND: Patients with a coronary artery calcium (CAC) score >300 on dedicated CAC scoring computed tomography (CT) are at equivalent risk of major adverse cardiac events (MACE) as those with estab

I Ioannis Kyriakoulis

Genome-wide DNA methylation association study of recent and accumulated ozone exposure in the National Longitudinal Study of Adolescent to Adult Health (Add Health) Study

J Hazard Mater. 2026 Apr 13;510:142055. doi: 10.1016/j.jhazmat.2026.142055. Online ahead of print.ABSTRACTGround-level ozone exposure poses a significant public health threat, linked to respiratory problems, cardiovascular disease, and cognitive decline. Emerging evidence suggests that DNA methylati

F Fang Fang

Clinical relevance of extrapulmonary chest computed tomography findings in COPD and asthma: A narrative review of established evidence in COPD and emerging insights in asthma

Respir Investig. 2026 Apr 17;64(3):101432. doi: 10.1016/j.resinv.2026.101432. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) and asthma pose health and socioeconomic challenges worldwide. While management strategies mainly target airway and parenchymal pathology, extrapul

N Naoya Tanabe

Inflammation-induced cysts mimic honeycombing on high-resolution computed tomography in rheumatoid arthritis-associated usual interstitial pneumonia

Respir Investig. 2026 Apr 17;64(3):101419. doi: 10.1016/j.resinv.2026.101419. Online ahead of print.ABSTRACTBACKGROUND: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) often manifests with a usual interstitial pneumonia (UIP) pattern and has a poor prognosis similar to idiopathic

Y Yasuhiko Yamano

Discovery of novel tert-butylhydroquinone derivatives as potential anti-endothelial injury agents: Synthesis, in vitro, and in vivo evaluation

Bioorg Chem. 2026 Apr 15;176:109865. doi: 10.1016/j.bioorg.2026.109865. Online ahead of print.ABSTRACTTert-butyl hydroquinone (tBHQ) is widely used as a food additive due to its superior protective properties, making it a valuable component in the food, cosmetic, and pharmaceutical industries. This

J Juan Zhang