Impact of Study Hypotheses on Results From Randomized Clinical Trials: Comparison Between Standard and Noninferiority Randomized Clinical Trials
Ann Intern Med. 2026 Jan 27. doi: 10.7326/ANNALS-25-01344. Online ahead of print.ABSTRACTBACKGROUND: In embarking on randomized clinical trials (RCTs), researchers can hypothesize that a more intensive treatment is better than a less intensive treatment (positive hypothesis) or that a less intensive

