The Effect of Bariatric Surgery on Homocysteine Levels: A Meta-analysis

Surg Laparosc Endosc Percutan Tech. 2026 Oct 26. doi: 10.1097/SLE.0000000000001521. Online ahead of print.ABSTRACTBACKGROUND: Homocysteine is an amino acid generated during the metabolism of methionine, which is an essential amino acid. Elevated levels of homocysteine are identified as an independen

T Tannaz Jamialahamdi

Coronary artery calcium scoring and coronary computed tomography angiography in familial hypercholesterolemia: current evidence and future directions

Curr Opin Lipidol. 2026 Oct 27. doi: 10.1097/MOL.0000000000001066. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Familial hypercholesterolemia is a prevalent genetic disorder characterized by lifelong elevated LDL-cholesterol (LDL-C), resulting in increased risk of premature atherosclerosis and c

L Lucia M Freire de Sousa

PROTEUS: A Prospective RCT Evaluating Use of AI in Stress Echocardiography

NEJM AI. 2024 Nov;1(11):AIoa2400865. doi: 10.1056/AIoa2400865. Epub 2024 Oct 18.ABSTRACTBACKGROUND: Use of artificial intelligence (AI) in cardiovascular imaging may potentially augment clinical decision-making in disease management, but no prospective randomized controlled trials have assessed the

R Ross Upton

Clinical Text Datasets for Medical Artificial Intelligence and Large Language Models - A Systematic Review

NEJM AI. 2024 Jun;1(6):AIra2400012. doi: 10.1056/AIra2400012. Epub 2024 May 17.ABSTRACTAbstractPrivacy and ethical considerations limit access to large-scale clinical datasets, particularly clinical text data, which contain extensive and diverse information and serve as the foundation for building c

J Jiageng Wu

A Classification of Safety Risks in Medical AI

NEJM AI. 2026 Sep;3(9):AIp2600358. doi: 10.1056/AIp2600358. Epub 2026 Aug 17.ABSTRACTAbstractIn clinical practice, patient safety is paramount, guided by the principle "first, do no harm." For medical AI to become a core component of clinical care, safety cannot be determined by its performance or a

B Bin Sheng

EchoNext-Mini: A Dataset and Baseline AI Model for Detecting Structural Heart Disease from Electrocardiograms

NEJM AI. 2026 May;3(5):AIdbp2500516. doi: 10.1056/AIdbp2500516. Epub 2026 Apr 16.ABSTRACTBACKGROUND: Structural heart disease (SHD) screening has traditionally been limited to echocardiography, limiting access and impacting patient outcomes. We recently published EchoNext, an artificial intelligence

J John Weston Hughes

Adoption of Artificial Intelligence-Based End Points - A New Era for Clinical Trials

NEJM AI. 2026 Jul;3(7):AIp2501235. doi: 10.1056/AIp2501235. Epub 2026 Jun 22.ABSTRACTAbstractEnd point evaluation is central to the evidence generation process in a clinical trial, and artificial intelligence (AI) tools have the potential to improve the efficiency and accuracy of this process. In 20

K Kushal T Kadakia

Designing Clinically Useful AI: A Blueprint for Impact

NEJM AI. 2026 Feb;3(2):AIp2500808. doi: 10.1056/AIp2500808. Epub 2026 Jan 22.ABSTRACTAbstractMost artificial intelligence (AI) tools in health care are evaluated on statistical performance for diagnostic accuracy alone, which often fails to account for the realities of the clinical systems into whic

S Shyon Parsa

TARGET-AI: A Foundational Approach for the Targeted Deployment of Artificial Intelligence Electrocardiography in the Electronic Health Record

NEJM AI. 2026 Feb;3(2):AIoa2500588. doi: 10.1056/AIoa2500588. Epub 2026 Jan 22.ABSTRACTBACKGROUND: Artificial intelligence (AI) applied to electrocardiograms (ECGs) offers promise for structural heart disease (SHD) screening, yet clinical integration remains challenged by high false-positive rates a

E Evangelos K Oikonomou

Silent Validation of a Longitudinal Model for Predicting Delayed Cerebral Ischemia in Real Time after Subarachnoid Hemorrhage

NEJM AI. 2026 Feb;3(2):AIoa2500749. doi: 10.1056/AIoa2500749. Epub 2026 Jan 22.ABSTRACTBACKGROUND: Longitudinal prediction of delayed cerebral ischemia (DCI) following subarachnoid hemorrhage (SAH) is crucial for timely interventions. Machine learning models for DCI risk prediction and stratificatio

J Jan Willms

Clinical Deployment of Real-Time Left Ventricular Ejection Fraction Estimation from Coronary Angiography

NEJM AI. 2025 May;2(5):AIcs2401008. doi: 10.1056/AIcs2401008. Epub 2025 Apr 24.ABSTRACTAbstractAssessment of left ventricular ejection fraction (LVEF) is crucial for prognosis and management in acute coronary syndrome (ACS). While echocardiography is the standard assessment method, assessment via le

P Pascal Thériault-Lauzier

Calibration of ECG-Based Deep-Learning Algorithm Scores for Patients Flagged as High Risk for Hypertrophic Cardiomyopathy

NEJM AI. 2025 May;2(5):AIoa2400421. doi: 10.1056/AIoa2400421. Epub 2025 Apr 24.ABSTRACTBACKGROUND: Despite optimism for the incorporation of deep-learning (DL) algorithms into clinical practice, there is a lack of prospective data on how U.S. Food and Drug Administration (FDA)-cleared algorithms fun

J Joshua Lampert

Four-Channel ECG as a Single Source for Early Diagnosis of Cardiac Hypertrophy and Dilation - A Deep Learning Approach

NEJM AI. 2024 Oct;1(10):AIoa2300297. doi: 10.1056/AIoa2300297. Epub 2024 Sep 26.ABSTRACTBACKGROUND: The electrocardiogram (ECG) remains the most commonly used screening tool for cardiac diseases. Although cardiac hypertrophy, dilation, and enlargement are important causes of heart failure and sudden

H Hongling Zhu

Effect of diet-induced plasma ceramide on human in vivo microvascular endothelial function

Am J Physiol Heart Circ Physiol. 2026 Nov 1;331(5):H1718-H1730. doi: 10.1152/ajpheart.90085.2026. Epub 2026 Oct 13.ABSTRACTElevated plasma ceramides and microvascular endothelial dysfunction are separately implicated in the incidence of cardiovascular disease. Exogenous exposure and endogenous accum

T Tijana Simovic

Generating Cardiac Magnetic Resonance Images from Electrocardiograms - A Multicenter Study

NEJM AI. 2026 Apr;3(4):AIoa2500549. doi: 10.1056/AIoa2500549. Epub 2026 Mar 26.ABSTRACTBACKGROUND: Cardiovascular disease (CVD) requires early and accurate diagnosis to improve outcomes. Cardiac magnetic resonance (CMR) imaging provides gold-standard functional and structural insights but remains li

Z Zhengyao Ding

Artificial Intelligence-Enhanced Auscultation to Identify Left Ventricular Dysfunction - Development and External Validation in Prospective Multicenter Studies

NEJM AI. 2026 Nov;3(11):AIoa2600258. doi: 10.1056/AIoa2600258. Epub 2026 Oct 15.ABSTRACTBACKGROUND: Left ventricular dysfunction (LVD) is common and associated with adverse prognosis, even in asymptomatic individuals. Early treatment improves outcomes, underscoring the need for efficient strategies

E Eiichiro Sato

Changes in Anthropometric, Metabolic, and Micronutrient Features Among Patients with Severe Obesity Awaiting Metabolic and Bariatric Surgery

Obes Facts. 2026 Oct 26:adzag011. doi: 10.1159/ofa/adzag011. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVE: Due to high demand for metabolic and bariatric surgery, patients often face significant waiting periods before undergoing the procedure. This study aimed to investigate trends in weig

A Ali Kabir

Effect of Activin Type II Receptor Signaling in Patients With HFpEF and Pulmonary Hypertension: A Critical Analysis of Biological Mechanisms and Clinical Trials

Circulation. 2026 Oct 27;154(17):1739-1749. doi: 10.1161/CIRCULATIONAHA.126.081957. Epub 2026 Oct 26.ABSTRACTThe totality of evidence indicates that the mechanisms underlying the increase in pulmonary vascular resistance in patients with combined postcapillary and precapillary pulmonary hypertension

M Milton Packer

Cytoprotection for Acute Ischemic Stroke: Critical Appraisal of Recent Clinical Trials

Stroke. 2026 Nov;57(11):3475-3480. doi: 10.1161/STROKEAHA.126.055936. Epub 2026 Oct 26.ABSTRACTSeveral phase III clinical trials testing cytoprotective approaches have recently been completed, and many of these studies report a clinical benefit. Reviewing the outcomes of these trials in light of the

J Johannes Boltze

Depressive symptoms are associated with the incidence of frailty in older adults with cardiometabolic diseases: Interaction between depression and diabetes

PLoS One. 2026 Oct 26;21(10):e0360802. doi: 10.1371/journal.pone.0360802. eCollection 2026.ABSTRACTBACKGROUND: Older adults with diabetes are prone to frailty and increased mortality.AIM: In this longitudinal study, we examined the association between depressive symptoms and the incidence of frailty

F Fumino Kobayashi

Prevalence and factors associated with sarcopenia in individuals with stroke undergoing rehabilitation: A cross-sectional study

PLoS One. 2026 Oct 26;21(10):e0361113. doi: 10.1371/journal.pone.0361113. eCollection 2026.ABSTRACTOBJECTIVE: To determine the prevalence of sarcopenia and identify clinical and functional factors independently associated with confirmed sarcopenia in individuals with stroke undergoing rehabilitation

F Fernando Shizuo Ida

Recovery experiences and perceptions of quality of life after percutaneous coronary intervention for ST-elevation myocardial infarction: An interpretive descriptive qualitative study

PLoS One. 2026 Oct 26;21(10):e0360291. doi: 10.1371/journal.pone.0360291. eCollection 2026.ABSTRACTBACKGROUND: Cardiovascular diseases remain the leading cause of mortality globally, with a disproportionate burden in low- and middle-income countries. Primary percutaneous coronary intervention is the

F Fasaha F Haji

MIF inhibitor ISO-1 attenuates ischemia-reperfusion injury in a rat model of donation after circulatory death liver transplantation

PLoS One. 2026 Oct 26;21(10):e0361214. doi: 10.1371/journal.pone.0361214. eCollection 2026.ABSTRACTMacrophage migration inhibitory factor (MIF) is an early mediator of ischemia-reperfusion injury (IRI), however, the evidence on its role in orthotopic liver transplantation (OLT), particularly with do

D Deniz Uluk

Squamous Cell Carcinoma in the Diabetic Foot: A Review of Published Case Reports

J Foot Ankle Res. 2026 Dec;19(4):e70217. doi: 10.1002/jfa2.70217.ABSTRACTINTRODUCTION: Squamous cell carcinoma (SCC) is a malignant tumour arising from epidermal keratinocytes and is the second most common form of skin cancer globally. Although relatively rare on the foot, SCC and its variants may o

M Matthew R Carroll