Targeted inhibition of JAK2 phosphorylation by GenX disrupts the JAK2-STAT3 pathway and induces cardiovascular toxicity in zebrafish: Insights from network toxicology and molecular dynamics

Toxicol Appl Pharmacol. 2026 Jul 19:117964. doi: 10.1016/j.taap.2026.117964. Online ahead of print.ABSTRACTCongenital heart disease is a leading cause of infant death, arising from genetic and environmental factors. GenX, a replacement for legacy pollutants, is now a widespread contaminant. However,

Y Yuzhi Zhao

Molecular signatures of the gut microbiota that affect longevity

Biochem Pharmacol. 2026 Jul 19:118267. doi: 10.1016/j.bcp.2026.118267. Online ahead of print.ABSTRACTThe human colonic microbiota has been estimated to contain 38 trillion bacteria whereas the total human somatic cells constitute 30 trillion. The mutualistic relationship between host and microbiome

D Diren Beyoğlu

Efficacy and safety of cytoreductive nephrectomy combined with thrombectomy in metastatic renal cell carcinoma with venous tumor thrombus: a real-world study based on inverse probability of treatment weighting

World J Urol. 2026 Jul 19;44(1):504. doi: 10.1007/s00345-026-06616-6.ABSTRACTBACKGROUND: Cytoreductive nephrectomy (CN) combined with thrombectomy remains controversial for metastatic renal cell carcinoma with venous tumor thrombus (mRCC-VTT), and optimal patient selection remains undefined.METHODS:

C Changwei Shi

Cardiovascular risk assessment in oncologic patients. A narrative review

Hell J Nucl Med. 2026 Jan-Apr;29 Suppl:43-52.ABSTRACTSystematic cardiovascular risk assessment and stratification across the entire cancer care continuum is essential among cancer patients, largely due to potential cardiotoxic effects of oncologic therapeutic regiments. Prior to initiation of cancer

C Christos T Lafaras

Accuracy and stability of DeepSeek-R1 and GPT-4o on pediatric questions

Digit Health. 2026 Jul 17;12:20552076261456893. doi: 10.1177/20552076261456893. eCollection 2026 Jan-Dec.ABSTRACTBACKGROUND: Large language models are increasingly applied in medical education and clinical decision support. However, comparative evaluations of their performance on pediatric content-s

Q Qibo Hu