Extreme cardiovascular risk as a major barrier to LDL-C target achievement: insights from ITACARE-P registry

Nutr Metab Cardiovasc Dis. 2026 Sep 23:105010. doi: 10.1016/j.numecd.2026.105010. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Achieving low-density lipoprotein cholesterol (LDL-C) targets remains challenging in secondary cardiovascular prevention despite the availability of effective lipid-lo

F Francesco Giallauria

Association of single nucleotide polymorphisms in lipid metabolism and vascular function genes with risk of cardiovascular disease

Nutr Metab Cardiovasc Dis. 2026 Jul 22:104880. doi: 10.1016/j.numecd.2026.104880. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Atherosclerosis progressively leads to cardiovascular diseases (CVDs). Genetic variants in lipid and vascular related genes can impact cardiovascular health due to alt

N None Jawaria

Structure-guided development of G protein-biased apelin receptor agonists for cardiovascular disease

J Zhejiang Univ Sci B. 2026 Oct 23;27(10):1059-1065. doi: 10.1631/jzus.B2600160.ABSTRACTApelin receptor (APLNR) is a crucial G protein-coupled receptor that plays a central role in cardiovascular homeostasis; therefore, it represents a promising therapeutic target for heart failure, myocardial infar

W Weiwei Wang

Extensive Arterial Thrombosis Complicating Acute Pancreatitis: A Case Report and Literature Review

Korean J Gastroenterol. 2026 Oct 25;86(4):468-476. doi: 10.4166/kjg.2026.035.ABSTRACTArterial thrombosis is a rare but potentially life-threatening complication of acute pancreatitis, with poorly defined clinical characteristics. This paper presents a case of extensive large-artery thrombosis compli

M Min-Seok Cho

Effect of mycophenolate mofetil on in-stent restenosis after percutaneous coronary intervention in patients with autoimmune hepatitis and overlap syndrome complicated with coronary heart disease

Zhonghua Yi Xue Za Zhi. 2026 Oct 27;106(39):4281-4288. doi: 10.3760/cma.j.cn112137-20260509-01235.ABSTRACTObjective: To investigate the effect of mycophenolate mofetil on in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with autoimmune hepatitis (AIH) and overlap

F F Q Dong

Expert consensus on practice of echocardiography in adult pulmonary hypertension (2026 edition)

Zhonghua Yi Xue Za Zhi. 2026 Oct 27;106(39):4224-4251. doi: 10.3760/cma.j.cn112137-20260313-00700.ABSTRACTPulmonary hypertension (PH) is a clinical syndrome characterized by elevated pulmonary arterial pressure and increased pulmonary vascular resistance, which eventually leads right failure or even

P Pulmonary Vascular Group of Chinese Medical Doctor Association of Cardiology

Acute Profound Hypotension Following Intraoperative Plasma Transfusion-A Case Series

Acta Anaesthesiol Scand. 2027 Jan;71(1):e70365. doi: 10.1111/aas.70365.ABSTRACTBACKGROUND: Blood transfusions can be lifesaving but carry risks of serious adverse reactions, including the less recognized hypotensive transfusion reaction, characterized by hypotension that may be difficult to distingu

T Tommy Batz

Time-Dependent Mortality Risk in Lean Metabolic Dysfunction-Associated Steatotic Liver Disease During Long-Term Follow-Up

J Gastroenterol Hepatol. 2026 Oct 25. doi: 10.1111/jgh.70845. Online ahead of print.ABSTRACTBACKGROUND AND AIM: The prognosis of lean metabolic dysfunction-associated steatotic liver disease (MASLD) remains controversial. We investigated the long-term prognosis of lean MASLD and its time-dependent a

E Enrui Xie

The PHLPP paradox revisited: from canonical AKT phosphatases to signaling pseudoenzymes in human disease

Biochem Pharmacol. 2026 Oct 25:118573. doi: 10.1016/j.bcp.2026.118573. Online ahead of print.ABSTRACTPHLPP1 and PHLPP2 (pleckstrin homology-domain leucine-rich-repeat protein phosphatases) are multidomain signaling proteins that have been associated with the regulation of AKT phosphorylation in seve

E Esraa M Shaaban

Transitions in metabolically healthy obesity based on a novel definition and their association with incident cardiovascular disease: A cohort study

Endocr Pract. 2026 Oct 25:S1530-891X(26)01294-2. doi: 10.1016/j.eprac.2026.10.011. Online ahead of print.ABSTRACTOBJECTIVE: A new metabolic health definition has been developed for cardiovascular disease (CVD) risk stratification. This study aimed to assess the stability of this newly defined metabo

Y Yin Zeng

Role of apoptosis and necroptosis in cardiac dysfunction during the development of heart disease

J Mol Cell Cardiol. 2026 Oct 25:S0022-2828(26)00164-1. doi: 10.1016/j.yjmcc.2026.10.009. Online ahead of print.ABSTRACTCell death plays a well established role in the pathogenesis of heart disease, with increasing evidence highlighting the complexity and plasticity of different underlying molecular

A Adriana Adameova

The dual role of BDNF in epilepsy: insights from calpain-mediated TrkB-FL cleavage

Pharmacol Res. 2026 Oct 25:109702. doi: 10.1016/j.phrs.2026.109702. Online ahead of print.ABSTRACTDespite the efficacy of current antiseizure medications in managing seizures, approximately one-third of patients develop refractory epilepsy, highlighting an urgent need to uncover the molecular mechan

L Leonor Ribeiro-Rodrigues

Targeted exome sequencing Delineates Subtype-Specific genetic Architecture and BMPR2-Associated Prognosis in Chinese paediatric pulmonary arterial hypertension

Gene. 2026 Oct 25:150453. doi: 10.1016/j.gene.2026.150453. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) exhibits greater genetic enrichment in children than in adults; however, genotype-phenotype correlations in Chinese paediatric PAH remain poorly defined. We performed target

T Tai-Quan Su

Correction to: 2026 ESC Guidelines for the management of cardiovascular disease and chronic kidney disease, in collaboration with the European Renal Association (ERA): Developed by the task force on the management of cardiovascular disease and chronic kidney disease of the European Society of Cardiology (ESC)

No abstractEur Heart J. 2026 Oct 26:ehag884. doi: 10.1093/eurheartj/ehag884. Online ahead of print.NO ABSTRACTPMID:42927774 | DOI:10.1093/eurheartj/ehag884

Glial lipid reprogramming in brain aging: Lipid identity, organelle stress, and redox vulnerability

Redox Biol. 2026 Oct 23;98:104453. doi: 10.1016/j.redox.2026.104453. Online ahead of print.ABSTRACTBrain aging is accompanied by progressive glial dysfunction, impaired metabolic adaptation, oxidative stress, and increased susceptibility to neurodegenerative disease. Although many studies of lipid m

M Mandeep Rana

Genetic Insights Into Cardiomyopathy With Restrictive Phenotype: Implications for Diagnosis and Personalized Care

Mol Genet Genomic Med. 2026 Nov;14(11):e70323. doi: 10.1002/mgg3.70323.ABSTRACTBACKGROUND: Cardiomyopathy with a restrictive phenotype is uncommon, genetically heterogeneous, and difficult to distinguish from advanced hypertrophic or dilated cardiomyopathy. We aimed primarily to determine the diagno

N Nianwei Zhou

DAPAgliflozin-Related Cardiac REverse Remodeling by 2D and 3D Echocardiography in OptiMally Treated HFrEF Patients: The DAPA-REM Study

Echocardiography. 2026 Oct;43(10):e70654. doi: 10.1111/echo.70654.ABSTRACTPURPOSE: Sodium-glucose cotransporter-2 inhibitors promote cardiac reverse remodeling in heart failure (HF), yet data integrating two-dimensional and three-dimensional echocardiography (2DE and 3DE, respectively) in optimally

N Nicola Amelotti

Anomalous Coronary Sinus and Persistent Left Superior Vena Cava Drainage Into the Left Atrium: A Multimodality Imaging Case

Echocardiography. 2026 Oct;43(10):e70658. doi: 10.1111/echo.70658.ABSTRACTA 26-year-old woman presented with palpitations and exertional dyspnea. Echocardiography suggested an inferior sinus venosus atrial septal defect, while cardiac CT angiography revealed a 26 × 32 mm defect with inferior vena ca

C Cemre Turgul

BDH1 Attenuates Macrophage Foam Cell Formation and Inflammation in Atherosclerosis Via Modulating Histone H3K9 Acylation Balance and Activating PPAR Signaling

J Biochem Mol Toxicol. 2026 Nov;40(11):e71141. doi: 10.1002/jbt.71141.ABSTRACTβ-Hydroxybutyrate dehydrogenase 1 (BDH1) has been implicated in metabolic disorders. Nevertheless, its function and underlying mechanisms in atherosclerosis (AS) remain ambiguous. A high-fat diet-fed apolipoprotein E-defic

Y Yu Wang

Outcome-specific associations of remnant cholesterol with myocardial infarction and stroke across traditional risk factor burden

J Thromb Thrombolysis. 2026 Oct 25. doi: 10.1007/s11239-026-03421-1. Online ahead of print.ABSTRACTRemnant cholesterol (RC) is considered a contributor to residual cardiovascular risk, but whether its associations with specific cardiovascular outcomes vary according to the burden of traditional card

R Ruobing Tian

The retrieved venous thrombus as a translational platform: a methodologic roadmap for venous immunothrombosis

J Thromb Thrombolysis. 2026 Oct 25. doi: 10.1007/s11239-026-03420-2. Online ahead of print.ABSTRACTPercutaneous mechanical thrombectomy is now widely used for iliofemoral deep vein thrombosis (DVT) and intermediate-risk pulmonary embolism (PE) across several device platforms, and every procedure yie

L Luca Galassi

In-Hospital and One-Year Outcomes After Percutaneous Coronary Intervention for Chronic Coronary Occlusion in Octogenarians

Cardiol Ther. 2026 Oct 25. doi: 10.1007/s40119-026-00485-1. Online ahead of print.ABSTRACTINTRODUCTION: Older patients often present with complex coronary artery disease alongside multiple comorbidities. There is limited data on the outcomes of percutaneous coronary intervention (PCI) for chronic to

D Danial Amoey

Analysis of mRNA and microRNA profiles in ischemic cardiomyopathy with LVAD support

Mol Biol Rep. 2026 Oct 25;53(1):1816. doi: 10.1007/s11033-026-13007-y.ABSTRACTBACKGROUND: Cardiac remodeling after myocardial infarction is common, and recovery from end stage ischemic cardiomyopathy (ICM) with left ventricular assist device (LVAD) therapy remains rare. Our goal was to identify micr

K Kajari Dhar

Predictors of in-hospital venous thromboembolism in patients undergoing primary total hip arthroplasty

Eur J Orthop Surg Traumatol. 2026 Oct 25;36(1):422. doi: 10.1007/s00590-026-04998-2.ABSTRACTPURPOSE: This study evaluated the national inpatient incidence, patient characteristics, and independent predictors of VTE following primary THA.METHODS: A retrospective cohort study was performed using the N

L Leonidas E Mastrokostas