J Mech Behav Biomed Mater. 2026 Apr 28;179:107447. doi: 10.1016/j.jmbbm.2026.107447. Online ahead of print.ABSTRACTTranscatheter valve replacement has become the established standard therapy for inoperable, high- and intermediate-risk patients with severe symptomatic aortic stenosis. Leaflet damage
Pain Med Case Rep. 2026 Apr;10(2):195-199.ABSTRACTBACKGROUND: Thoracic back pain is an understudied clinical entity, and few evidence-based guidelines exist for its evaluation. Pulmonary embolism can present atypically with referred pain to the thoracic region if the visceral pleura becomes involved
Pain Med Case Rep. 2026 Apr;10(2):187-189.ABSTRACTBACKGROUND: Overactive bladder and associated incontinence are increasingly treated with onabotulinumtoxinA (Botox®) intradetrusor injections. An observed but poorly understood side effect is generalized abdominal pain that simulates cramps.CASE REPO
Pain Med Case Rep. 2026 Apr;10(2):183-186.ABSTRACTBACKGROUND: Stellate ganglion block is a salvage therapy used for refractory or incessant ventricular tachycardia when conservative measures have failed.CASE REPORT: This case involves a man in his 60s with a history of hypertension, glaucoma, heart
Pain Med Case Rep. 2026 Apr;10(2):177-181.ABSTRACTBACKGROUND: Erythromelalgia is a rare pain disorder, which causes hyperperfused, red, and painful extremities. Symptoms can be so extreme that patients often resort to soaking their limbs in ice-cold water for hours on end and socially isolating them
Pain Med Case Rep. 2026 Apr;10(2):161-164.ABSTRACTBACKGROUND: Small fiber neuropathy is a painful diabetes complication that may present with burning pain, dysesthesia, and autonomic features such as swelling, color changes, and hyperhidrosis. Some cases overlap with erythromelalgia, a rare conditio
Pain Med Case Rep. 2026 Apr;10(2):115-119.ABSTRACTBACKGROUND: Erythromelalgia (EM) is a very rare condition characterized by severe paroxysmal pain in the upper or lower extremities and erythema, resulting in significant morbidity and incapacity. Typically, multiple specialty evaluations rule out co
Adv Emerg Nurs J. 2026 Apr-Jun 01;48(2):75-80. doi: 10.1097/TME.0000000000000620.ABSTRACTCervical artery dissection represents a relevant cause of stroke, predominantly in young adults. The diagnosis can be challenging both clinically and radiographically frequently resulting in underdiagnosis, and
J Cardiovasc Med (Hagerstown). 2026 Apr 1;27(4):318-325. doi: 10.2459/JCM.0000000000001870. Epub 2026 Mar 27.ABSTRACTBACKGROUND: Pregnancy is generally well tolerated in patients with arrhythmogenic cardiomyopathy (AC), but there are limited data comparing right-dominant AC (ARVC) and left-dominant
J Cardiovasc Med (Hagerstown). 2026 Apr 1;27(4):306-317. doi: 10.2459/JCM.0000000000001862. Epub 2026 Mar 27.ABSTRACTBACKGROUND: Dual pathway inhibition (DPI) with low-dose rivaroxaban and aspirin offers superior ischemic protection compared with single-agent therapy in patients with peripheral arte
J Cardiovasc Med (Hagerstown). 2026 Apr 1;27(4):280-286. doi: 10.2459/JCM.0000000000001876. Epub 2026 Mar 27.ABSTRACTAIMS: ST-elevation myocardial infarction (STEMI) in very elderly patients (≥85 years) poses a major clinical challenge due to frailty and comorbidities. In the general population, lef
J Cardiovasc Med (Hagerstown). 2026 Apr 1;27(4):268-276. doi: 10.2459/JCM.0000000000001875. Epub 2026 Apr 10.ABSTRACTAIMS: Transcatheter aortic valve implantation (TAVI) is the standard of care for elderly (≥70 years) or high-risk patients with severe aortic stenosis, yet current guidelines recommen
J Am Soc Nephrol. 2026 May 1. doi: 10.1681/ASN.0000001117. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) is strongly associated with atrial fibrillation. Understanding the biological pathways for this association and creating predictive models has been challenging. Left atri
Aging Dis. 2026 Apr 24. doi: 10.14336/AD.2025.1557. Online ahead of print.ABSTRACTInflammaging refers to the chronic, low-grade, sterile inflammatory state that emerges as a hallmark of biological aging and is increasingly recognized as a contributor to functional decline, frailty, and the progressi
Aging Dis. 2026 Apr 29. doi: 10.14336/AD.2025.1556. Online ahead of print.ABSTRACTAging is the predominant risk factor for several chronic disorders; therefore, elucidating the molecular and cellular mechanisms underlying age-related pathologies is essential for therapeutic advancement. Micheliolide
Neurogenetics. 2026 May 1;27(1):35. doi: 10.1007/s10048-026-00905-3.ABSTRACTHereditary cerebral small vessel disease (CSVD) associated with duplication involving region 13q34, which includes both COL4A1/COL4A2 is relatively rare. Here, we report a Japanese family with this duplication along with dil
Geroscience. 2026 May 1. doi: 10.1007/s11357-026-02272-1. Online ahead of print.ABSTRACTAging is a major risk factor for chronic diseases. Unlike the general population, members of long-lived families maintain exceptional health as they age, with over 10 years delayed onset of their first chronic di
FASEB J. 2026 May 15;40(9):e71786. doi: 10.1096/fj.202504826R.ABSTRACTNeonatal hypoxic-ischemic encephalopathy (NHIE) is a leading cause of morbidity and mortality in term infants. The anesthetic dexmedetomidine (Dex) has been shown to reduce brain damage. In this study, hypoxia-ischemia (HI) in neo
Naunyn Schmiedebergs Arch Pharmacol. 2026 May 1. doi: 10.1007/s00210-026-05404-8. Online ahead of print.ABSTRACTAstragaloside IV (AS-IV), a compound extracted from Radix Astragali, has been shown to have beneficial effects on cardiovascular disease. However, the role of AS-IV in cardiac toxicity cau
Eur J Pediatr. 2026 May 1;185(5):332. doi: 10.1007/s00431-026-07008-z.ABSTRACTKawasaki disease (KD) is an acute, immune-mediated medium-vessel vasculitis and the leading cause of acquired heart disease in children, yet its underlying etiology remains only partially defined. Emerging evidence implica
Cell Mol Life Sci. 2026 May 1. doi: 10.1007/s00018-026-06229-7. Online ahead of print.ABSTRACTHypertension is increasingly recognized as a contributor to intestinal barrier disruption and gut microbiota dysbiosis, thereby promoting systemic inflammation and end-organ damage. Sirtuin 7 (SIRT7), a nic
Mayo Clin Proc. 2026 Apr 30:S0025-6196(26)17386-8. doi: 10.1016/j.mayocp.2026.02.002. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) across different heart failure phenotypes in patients with chronic kidney disease (
JACC Case Rep. 2026 Mar 28:107653. doi: 10.1016/j.jaccas.2026.107653. Online ahead of print.ABSTRACTBACKGROUND: Regular physical activity confers substantial cardiovascular benefits, yet it may in rare cases precipitate sudden cardiac arrest (SCA) or sudden cardiac death (SCD) in predisposed individ
CONCLUSIONS: This study demonstrated that Selebeta^(®) PR is an effective and well-tolerated treatment for adults with OAB, with no clinically meaningful increase in blood pressure and a low incidence of adverse events.Investig Clin Urol. 2026 May;67(3):273-280. doi: 10.4111/icu.20250489.ABSTRACTPUR
