Sex-related presentation, outcome, and treatment in CICU: the SPOTlight STUDY

Clin Res Cardiol. 2025 Dec 8. doi: 10.1007/s00392-025-02816-z. Online ahead of print.ABSTRACTKEY POINTS: WHAT IS ALREADY KNOWN: • Sex-related differences in cardiovascular disease presentation, management, and outcomes have been increasingly recognized in recent years. • Women with acute cardiovascu

A Alessia d'Aiello

Brain injury biomarkers and intraoperative hypotension: associations with pituitary hormone deficiency following transsphenoidal endoscopic surgery for non-functioning pituitary adenomas

Pituitary. 2025 Dec 8;29(1):9. doi: 10.1007/s11102-025-01597-y.ABSTRACTPURPOSE: Factors related to the development of new pituitary hormone deficiencies following transsphenoidal surgery for non-functioning pituitary adenomas are multifactorial and remain poorly understood. We explored associations

M Martin Thorsson

Acute Right Ventricular Failure in the Medical ICU

Lung. 2025 Dec 8;203(1):107. doi: 10.1007/s00408-025-00862-y.ABSTRACTRight ventricular failure (RVF) is a complex clinical syndrome resulting from anatomical and physiological dysfunction of the right ventricle, marked by insufficient cardiac output state, elevated filling pressures, and elevated ce

A Amos E Dodi

Stress-Induced calcium mishandling in cardiac (Patho)physiology

Calcium (Ca^(2+)) is an essential regulator of cardiac function. Particularly, Ca^(2+) is the primary link between the electrical signals regulating contractility of the myocytes and thus allowing the heart chambers to relax and refill completely with blood. Additionally, Ca^(2+) controls numerous o

D Dan J Bare

Predictive health index: integrating body composition and heart rate variability metrics with artificial intelligence to predict chronic disease risk and specific chronic non-communicable diseases

Hormones (Athens). 2025 Dec 8. doi: 10.1007/s42000-025-00727-2. Online ahead of print.ABSTRACTPURPOSE/OBJECTIVE: The field of predictive medicine focuses on assessing disease risk and implementing preventive strategies with a view to either preventing disease onset entirely or significantly minimizi

D Dario Boschiero

The IGVF catalog-from genetic variation to function

Nucleic Acids Res. 2025 Dec 8:gkaf1341. doi: 10.1093/nar/gkaf1341. Online ahead of print.ABSTRACTGenomic variation between individuals is essential for understanding how differences in the genome sequence affect molecular and cellular processes. The Impact of Genomic Variation on Function (IGVF) Con

D Daofeng Li

Interferon signaling pathways in health and disease

Mol Biomed. 2025 Dec 8;6(1):135. doi: 10.1186/s43556-025-00381-5.ABSTRACTInterferons (IFNs) are a family of cytokines that orchestrate a wide range of antiviral, immunoregulatory, and antitumor activities. This review provides a comprehensive overview of the molecular mechanisms underlying IFN signa

C Chunli Wen

SEdb 3.0: a comprehensive super-enhancer database across multiple species

Nucleic Acids Res. 2025 Dec 8:gkaf1294. doi: 10.1093/nar/gkaf1294. Online ahead of print.ABSTRACTSuper-enhancers (SEs) are key DNA cis-regulatory elements that play a central role in regulating tissue/cell-specific gene expression, thereby maintaining cellular identity and function. SEdb 3.0 (http:/

S Shuang Song

Tuberculosis Effusive-Constrictive Pericarditis

JACC Case Rep. 2025 Dec 8:106395. doi: 10.1016/j.jaccas.2025.106395. Online ahead of print.ABSTRACTBACKGROUND: Effusive-constrictive pericarditis is a rare pericardial syndrome characterized by the coexistence of constrictive physiology and pericardial effusion. Tuberculosis remains a leading cause

H Henrique Iahnke Garbin

10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2026

Diabetes Care. 2026 Jan 1;49(Supplement_1):S216-S245. doi: 10.2337/dc26-S010.ABSTRACTThe American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goal

A American Diabetes Association Professional Practice Committee for Diabetes*

12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes-2026

Diabetes Care. 2026 Jan 1;49(Supplement_1):S261-S276. doi: 10.2337/dc26-S012.ABSTRACTThe American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goal

A American Diabetes Association Professional Practice Committee for Diabetes*