JAMA Netw Open. 2025 Dec 1;8(12):e2547618. doi: 10.1001/jamanetworkopen.2025.47618.ABSTRACTIMPORTANCE: Respiratory syncytial virus (RSV) infection has recently been recognized as common among adults, but data on the burden of cardiovascular disease (CVD) beyond the immediate acute phase are lacking.
J Foot Ankle Res. 2025 Dec;18(4):e70106. doi: 10.1002/jfa2.70106.ABSTRACTBACKGROUND AND AIMS: In 2023 the International Working Group of the Diabetic Foot (IWGDF) published definitions for the diagnosis, remission and relapse of active Charcot neuro-osteoarthropathy (CN). Until 2023 authors had used
FASEB J. 2025 Dec 15;39(23):e71326. doi: 10.1096/fj.202502849R.ABSTRACTMacrophage migration inhibitory factor (MIF) has been reported as a detrimental factor in ischemic stroke in male animals. MIF concentration is increased in the cerebrospinal fluid and serum in hemorrhagic stroke patients. Howeve
Crit Care Explor. 2025 Dec 8;7(12):e1358. doi: 10.1097/CCE.0000000000001358. eCollection 2025 Dec 1.ABSTRACTBACKGROUND: Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder, characterized by neurocutaneous lesions. NF1 has a high degree of clinical variability, which can include
FASEB J. 2025 Dec 15;39(23):e71311. doi: 10.1096/fj.202502632R.ABSTRACTPathological cardiac hypertrophy is a major risk factor for myocardial ischemia, heart failure, and sudden cardiac death, yet its underlying mechanisms remain incompletely understood. Here, we identify Tripartite Motif Containing
Clin Res Cardiol. 2025 Dec 8. doi: 10.1007/s00392-025-02816-z. Online ahead of print.ABSTRACTKEY POINTS: WHAT IS ALREADY KNOWN: • Sex-related differences in cardiovascular disease presentation, management, and outcomes have been increasingly recognized in recent years. • Women with acute cardiovascu
Mol Neurobiol. 2025 Dec 8;63(1):268. doi: 10.1007/s12035-025-05373-8.ABSTRACTWe previously reported the important role of miR-30d-5p in neuronal apoptosis in developing brains with hypoxia-ischemia; however, the specific mechanisms remain unclear. Here, we studied the mechanisms underlying the effec
Pituitary. 2025 Dec 8;29(1):9. doi: 10.1007/s11102-025-01597-y.ABSTRACTPURPOSE: Factors related to the development of new pituitary hormone deficiencies following transsphenoidal surgery for non-functioning pituitary adenomas are multifactorial and remain poorly understood. We explored associations
Lung. 2025 Dec 8;203(1):107. doi: 10.1007/s00408-025-00862-y.ABSTRACTRight ventricular failure (RVF) is a complex clinical syndrome resulting from anatomical and physiological dysfunction of the right ventricle, marked by insufficient cardiac output state, elevated filling pressures, and elevated ce
Calcium (Ca^(2+)) is an essential regulator of cardiac function. Particularly, Ca^(2+) is the primary link between the electrical signals regulating contractility of the myocytes and thus allowing the heart chambers to relax and refill completely with blood. Additionally, Ca^(2+) controls numerous o
Eur Radiol. 2025 Dec 8. doi: 10.1007/s00330-025-12189-6. Online ahead of print.ABSTRACTOBJECTIVES: To compare machine learning models using different combinations of clinical and imaging variables for classifying ischemic stroke patients as having an onset-to-imaging (OTI) time within or beyond 4.5
Hormones (Athens). 2025 Dec 8. doi: 10.1007/s42000-025-00727-2. Online ahead of print.ABSTRACTPURPOSE/OBJECTIVE: The field of predictive medicine focuses on assessing disease risk and implementing preventive strategies with a view to either preventing disease onset entirely or significantly minimizi
Nucleic Acids Res. 2025 Dec 8:gkaf1341. doi: 10.1093/nar/gkaf1341. Online ahead of print.ABSTRACTGenomic variation between individuals is essential for understanding how differences in the genome sequence affect molecular and cellular processes. The Impact of Genomic Variation on Function (IGVF) Con
Mol Biomed. 2025 Dec 8;6(1):135. doi: 10.1186/s43556-025-00381-5.ABSTRACTInterferons (IFNs) are a family of cytokines that orchestrate a wide range of antiviral, immunoregulatory, and antitumor activities. This review provides a comprehensive overview of the molecular mechanisms underlying IFN signa
Nucleic Acids Res. 2025 Dec 8:gkaf1294. doi: 10.1093/nar/gkaf1294. Online ahead of print.ABSTRACTSuper-enhancers (SEs) are key DNA cis-regulatory elements that play a central role in regulating tissue/cell-specific gene expression, thereby maintaining cellular identity and function. SEdb 3.0 (http:/
Eur Heart J. 2025 Dec 8:ehaf958. doi: 10.1093/eurheartj/ehaf958. Online ahead of print.ABSTRACTAcute coronary syndromes are caused by obstructive coronary thrombosis complicating myocardial ischaemic disease and are dichotomously classified according to their electrocardiographic presentation as ST-
JACC Case Rep. 2025 Dec 8:106395. doi: 10.1016/j.jaccas.2025.106395. Online ahead of print.ABSTRACTBACKGROUND: Effusive-constrictive pericarditis is a rare pericardial syndrome characterized by the coexistence of constrictive physiology and pericardial effusion. Tuberculosis remains a leading cause
Diabetes Care. 2026 Jan 1;49(Supplement_1):S216-S245. doi: 10.2337/dc26-S010.ABSTRACTThe American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goal
Diabetes Care. 2026 Jan 1;49(Supplement_1):S261-S276. doi: 10.2337/dc26-S012.ABSTRACTThe American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goal
Clin Appl Thromb Hemost. 2025 Jan-Dec;31:10760296251405417. doi: 10.1177/10760296251405417. Epub 2025 Dec 8.ABSTRACTBackgroundCerebral venous thrombosis (CVT), a rare cause of stroke, primarily occurs in young individuals. The established treatment regimen involves anticoagulation with low molecular
Microbiol Spectr. 2025 Dec 8:e0167225. doi: 10.1128/spectrum.01672-25. Online ahead of print.ABSTRACTInvasive fungal infections caused by Candida albicans pose significant clinical challenges due to their high mortality rates and emerging drug resistance. In this study, we established Qcr8, an acces
Invest Ophthalmol Vis Sci. 2025 Dec 1;66(15):25. doi: 10.1167/iovs.66.15.25.ABSTRACTPURPOSE: To investigate the roles of Krüppel-like factor 10 (KLF10) and its inhibitor KLF10-IN-1 in regulating high-glucose/hypoxia-induced RPE cell apoptosis and their involvement in diabetic retinopathy (DR).METHOD
Future Cardiol. 2025 Dec 8:1-13. doi: 10.1080/14796678.2025.2599707. Online ahead of print.ABSTRACTCardiac amyloidosis (CA) can result in a restrictive cardiomyopathy, and heart transplantation (HT) remains the gold standard treatment for patients with end-stage heart failure secondary to amyloid ca
ACS Biomater Sci Eng. 2025 Dec 8. doi: 10.1021/acsbiomaterials.5c01187. Online ahead of print.ABSTRACTStemness of mouse embryonic stem cells (mESCs) can be maintained in vitro using biophysical factors including surface topography. More specifically, multidirectional symmetries have shown promise in
