Rinsho Ketsueki. 2026;67(9):1257-1270. doi: 10.11406/rinketsu.67.1257.ABSTRACTT-cell redirecting therapies, particularly BCMA-directed CAR-T-cell therapy and bispecific antibodies, have substantially advanced the treatment of multiple myeloma. These therapies induce deep responses in patients with r
Rinsho Ketsueki. 2026;67(9):1250-1256. doi: 10.11406/rinketsu.67.1250.ABSTRACTMultiple myeloma is an uncurable hematologic malignancy; however, survival outcomes have improved with the introduction of proteasome inhibitors, immunomodulatory drugs, and anti-CD38 monoclonal antibodies. Autologous tran
Rinsho Ketsueki. 2026;67(9):1053-1060. doi: 10.11406/rinketsu.67.1053.ABSTRACTSomatic mosaicism is emerging as a fundamental feature of human aging. Among its most common manifestations in men is acquired loss of the Y chromosome (LOY) in the hematopoietic system, which is most readily detected in b
Antioxid Redox Signal. 2026 Oct 28:15230864261501810. doi: 10.1177/15230864261501810. Online ahead of print.ABSTRACTINTRODUCTION: Renal fibrosis is a common pathological feature of chronic kidney disease (CKD), but effective therapies are still lacking. Ferroptosis has been increasingly associated w
J Atheroscler Thromb. 2026 Oct 28. doi: 10.5551/jat.RV22062. Online ahead of print.ABSTRACTTraditional management of atherosclerosis focuses primarily on cholesterol and triglycerides; however, lipoproteins also transport bioactive lipids that critically regulate systemic inflammation and metabolic
J Nippon Med Sch. 2026;93(5):422-428. doi: 10.1272/jnms.JNMS.2026_93-504.ABSTRACTA 68-year-old man with a history of lung cancer, prostate cancer, inflammatory bowel disease, and aortic aneurysm was referred for evaluation of a sudden decrease in platelet count. Coagulation findings indicated a diag
J Nippon Med Sch. 2026;93(5):394-401. doi: 10.1272/jnms.JNMS.2026_93-513.ABSTRACTBACKGROUND: Atrial cardiopathy (AC) has been proposed as a potential embolic mechanism in embolic stroke of undetermined source (ESUS); however, the distribution of AC biomarkers across ischemic stroke subtypes remains
No abstractObstet Gynecol Clin North Am. 2026 Dec;53(4):xv-xvi. doi: 10.1016/j.ogc.2026.07.008. Epub 2026 Aug 19.NO ABSTRACTPMID:42951448 | DOI:10.1016/j.ogc.2026.07.008
No abstractObstet Gynecol Clin North Am. 2026 Dec;53(4):xiii-xiv. doi: 10.1016/j.ogc.2026.08.001. Epub 2026 Aug 26.NO ABSTRACTPMID:42951447 | DOI:10.1016/j.ogc.2026.08.001
Obstet Gynecol Clin North Am. 2026 Dec;53(4):815-834. doi: 10.1016/j.ogc.2026.07.006. Epub 2026 Aug 11.ABSTRACTPregnancy and the postpartum period are times of significant hemodynamic change and can cause new cardiac disease, highlight previously unknown cardiovascular disease (CVD) or exacerbate kn
Obstet Gynecol Clin North Am. 2026 Dec;53(4):803-814. doi: 10.1016/j.ogc.2026.07.004. Epub 2026 Aug 10.ABSTRACTThe management of pregnant patients with cardiovascular (CV) disease is focused on optimizing maternal, obstetric, and fetal outcomes. In this article, we provide guidance on intrapartum ca
Obstet Gynecol Clin North Am. 2026 Dec;53(4):781-801. doi: 10.1016/j.ogc.2026.06.004. Epub 2026 Aug 11.ABSTRACTPregnant patients with cardiovascular disease benefit from early evaluation by a pregnancy heart team and formal risk stratification to guide delivery planning and determine the need for ca
Obstet Gynecol Clin North Am. 2026 Dec;53(4):765-779. doi: 10.1016/j.ogc.2026.07.005. Epub 2026 Sep 16.ABSTRACTCardiovascular disease complicates a small proportion of pregnancies but remains the leading cause of maternal mortality in the United States. Early recognition, risk stratification, and ti
Obstet Gynecol Clin North Am. 2026 Dec;53(4):747-764. doi: 10.1016/j.ogc.2026.07.003. Epub 2026 Sep 15.ABSTRACTSuboptimal prepregnancy metabolic health predisposes women to hypertensive disorders of pregnancy (HDP). Prevention of HDP starts with prepregnancy metabolic health optimization. If hyperte
Obstet Gynecol Clin North Am. 2026 Dec;53(4):723-746. doi: 10.1016/j.ogc.2026.07.001. Epub 2026 Sep 16.ABSTRACTVenous thromboembolism (VTE) remains a leading cause of maternal morbidity and mortality. Pregnancy is a hypercoagulable state that increases VTE risk due to physiologic and anatomic change
Obstet Gynecol Clin North Am. 2026 Dec;53(4):707-721. doi: 10.1016/j.ogc.2026.07.007. Epub 2026 Sep 16.ABSTRACTSyncope and presyncope symptoms occur commonly in pregnancy. Evaluation of syncope should include careful history and physical examination to determine underlying etiology. Patients with co
Obstet Gynecol Clin North Am. 2026 Dec;53(4):691-706. doi: 10.1016/j.ogc.2026.06.001. Epub 2026 Sep 15.ABSTRACTArrhythmias during pregnancy are increasingly recognized due to increased age, risk factors, and the physiologic cardiovascular changes of pregnancy. Premature atrial contractions, prematur
Obstet Gynecol Clin North Am. 2026 Dec;53(4):659-672. doi: 10.1016/j.ogc.2026.06.003. Epub 2026 Aug 4.ABSTRACTCardiovascular disease (CVD) is a leading cause of maternal mortality and is secondary to the rising rates of prepregnancy CVD risk factors. Pregnancy represents a unique physiologic state c
Obstet Gynecol Clin North Am. 2026 Dec;53(4):639-658. doi: 10.1016/j.ogc.2026.07.002. Epub 2026 Sep 15.ABSTRACTThe modified World Health Organization (mWHO) risk classification provides a practical framework to stratify maternal cardiovascular risk in pregnancy. For general obstetric providers, part
Obstet Gynecol Clin North Am. 2026 Dec;53(4):619-637. doi: 10.1016/j.ogc.2026.06.002. Epub 2026 Sep 16.ABSTRACTPreconception counseling and evaluation for individuals with cardiovascular disease is essential to optimize maternal and fetal outcomes by identifying risk and stabilizing conditions befor
No abstractOpen Heart. 2026 Oct 28;13(2):e004434. doi: 10.1136/openhrt-2026-004434.NO ABSTRACTPMID:42951308 | DOI:10.1136/openhrt-2026-004434
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2026 Nov-Dec;18(6):e70083. doi: 10.1002/wnan.70083.ABSTRACTMicroRNAs (miRNAs) are small, noncoding RNA molecules nearly 22 nucleotides in length that contribute significantly to regulating gene expression. Their aberrant expression patterns are associate
Clin Med (Lond). 2026 Oct 28:100666. doi: 10.1016/j.clinme.2026.100666. Online ahead of print.ABSTRACTBACKGROUND: Drug-induced QTc-prolongation is a major concern for developing ventricular arrhythmias, which may eventually lead to sudden cardiac death. Identifying high-risk patients is essential to
Diabetes Metab. 2026 Oct 28:101801. doi: 10.1016/j.diabet.2026.101801. Online ahead of print.ABSTRACTT1D is clinically heterogeneous, yet its key parameters are still largely interpreted in isolation. As a first step towards developing a digital twin for T1D, we aimed to build a phenotypic mapping a
