ALY688 Protects Against Myocardial Ischemia-Reperfusion Injury via Direct Effects and Rab8a-Dependent Extracellular Vesicles

J Extracell Vesicles. 2026 Sep;15(9):e70357. doi: 10.1002/jev2.70357.ABSTRACTDespite advances in percutaneous coronary intervention, ischemia-reperfusion (IR) injury remains a major cause of morbidity and mortality. Adiponectin confers broad cardioprotective effects, motivating the development of ad

H Hye Kyoung Sung

Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD-208 via Lysosomal Rerouting of CD63+ Compartments

J Extracell Vesicles. 2026 Sep;15(9):e70362. doi: 10.1002/jev2.70362.ABSTRACTPharmacological tools to selectively modulate extracellular vesicle (EV) secretion are scarce. Here, we identify the ALK5 (TGF-β receptor I) inhibitor SD-208 as a potent suppressor of small EV (sEV) secretion that acts inde

R Rahul Sanwlani

Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence: The ADHERE-ASCVD Randomized Clinical Trial

JAMA. 2026 Aug 29. doi: 10.1001/jama.2026.16372. Online ahead of print.ABSTRACTIMPORTANCE: Statin nonadherence is a leading, addressable driver of preventable cardiovascular events. Although health systems routinely use outreach to promote preventive care, most strategies are static and lack evidenc

A Ankeet S Bhatt

Electronic Nudges to Increase Influenza Vaccination Uptake in Young and Middle-Aged Patients with Heart Failure: A Prespecified Analysis of the NUDGE-FLU-CHRONIC Trial

No abstractCirc Heart Fail. 2026 Aug 29. doi: 10.1161/CIRCHEARTFAILURE.126.014891. Online ahead of print.NO ABSTRACTPMID:42667600 | DOI:10.1161/CIRCHEARTFAILURE.126.014891

N Niklas Dyrby Johansen

Non-Oncology Biomarkers in Precision Medicine: A Narrative Review

Ther Innov Regul Sci. 2026 Aug 29. doi: 10.1007/s43441-026-01041-8. Online ahead of print.ABSTRACTPrecision medicine has revolutionized oncology by leveraging biomarkers for individualized therapy selection, early diagnosis, and real-time disease monitoring. However, the application of biomarkers in

A Achilleas Livieratos

The Role of SGLT2 Inhibitors in the Prevention of Type 2 Diabetes: A Narrative Review of Current Evidence

Diabetes Ther. 2026 Aug 29. doi: 10.1007/s13300-026-01913-0. Online ahead of print.ABSTRACTINTRODUCTION: Prediabetes is a metabolic state that frequently precedes overt type 2 diabetes mellitus (T2DM) and is associated with an increased risk of micro- and macrovascular complications. Lifestyle modif

A Anna C Owczarczyk-Durma

Study on the Expression of MiR-642b-3p in Spontaneous Intracerebral Hemorrhage and Its Regulatory Mechanism on Endothelial Cell Injury

Neurochem Res. 2026 Aug 29;51(5):257. doi: 10.1007/s11064-026-04863-y.ABSTRACTSpontaneous cerebral hemorrhage (sICH) is one of the cerebrovascular diseases with the highest mortality rate. MicroRNAs (miRNAs) are implicated in the regulation of various pathological processes, however, the specific fu

Z Zhi Cao

The indirect effects of cognitive function in the association between stroke and quality of life among older adults in a rural community: A cross-sectional study

Qual Life Res. 2026 Aug 29;35(10):274. doi: 10.1007/s11136-026-04379-6.ABSTRACTPURPOSE: We examined whether cognitive function statistically accounted for associations between stroke and quality of life (QOL).METHODS: A cross-sectional survey included adults aged ≥ 60 years in Segamat, Malaysia. Cog

M Memory Lucy Mtambo

The identification of a PRKACA duplication at 19p13.12 in a female with PPNAD and thyroid carcinoma after a 20-year diagnostic journey

Fam Cancer. 2026 Aug 29;25(3):83. doi: 10.1007/s10689-026-00594-9.ABSTRACTRare pathogenic variants affecting components of the evolutionary conserved cAMP/protein kinase A (PKA) signalling pathway are implicated in a spectrum of adrenocortical disorders. Germline inactivating PRKAR1A variants leadin

M Marjoleine F Broekema

High levels of cell-free hemoglobin and iron in cerebral thrombi of pre-Omicron COVID-19 stroke patients: novel drivers of SARS-CoV-2-induced prothrombotic state

Acta Neuropathol. 2026 Aug 29;152(1):26. doi: 10.1007/s00401-026-03074-7.ABSTRACTThe pathophysiological mechanisms underlying the hypercoagulable state and thrombotic events associated with COVID-19 remain incompletely understood. To investigate prothrombotic alterations during SARS-CoV-2 infection,

M María Payá

Predictive value of early postoperative hemodynamic parameters of Rex shunt graft for graft thrombosis in children with cavernous transformation of the portal vein

Pediatr Surg Int. 2026 Aug 29;42(1):372. doi: 10.1007/s00383-026-06599-w.ABSTRACTOBJECTIVE: To investigate the predictive value of early hemodynamic parameters within Rex graft for postoperative graft thrombosis in children with cavernous transformation of the portal vein (CTPV).METHODS: A retrospec

L Limiao Xiao

Metabolic and macrovascular outcomes following simultaneous pancreas-kidney transplantation and kidney transplantation alone in recipients with type 1 diabetes mellitus: a systematic review and meta-analysis

Diabetologia. 2026 Aug 29. doi: 10.1007/s00125-026-06843-x. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Simultaneous pancreas-kidney transplantation (SPKTx) and kidney transplantation alone (KTx) are common treatment modalities for individuals with type 1 diabetes with end-stage kidney disease. T

H Harsham Choksi

Classification of intracardiac heart sounds for ventricular and atrial fibrillation based on feature fusion and voting ensemble learning

Med Biol Eng Comput. 2026 Aug 29. doi: 10.1007/s11517-026-03671-4. Online ahead of print.ABSTRACTArrhythmias, a significant category of cardiovascular diseases, including atrial fibrillation (AF) and ventricular fibrillation (VF), can result in severe complications and fatal outcomes, necessitating

Y Yiming Xin

Sex-specific effects of therapeutic hypothermia on short- and long-term microglial and astrocytic reactivity after severe neonatal hypoxia-ischemia

Metab Brain Dis. 2026 Aug 29;41(1):194. doi: 10.1007/s11011-026-01957-y.ABSTRACTTherapeutic hypothermia (TH) is the standard treatment to reduce mortality and neurological impairments after neonatal hypoxia-ischemia (HI). However, TH does not fully suppress neuroinflammation, leading to persistent n

R Ricardo Ribeiro Nunes

From Barrier Disruption and Immune Dysregulation to Targeted Therapies in Atopic Dermatitis

Clin Rev Allergy Immunol. 2026 Aug 29;69(1):72. doi: 10.1007/s12016-026-09198-8.ABSTRACTAtopic dermatitis (AD) is a heterogeneous inflammatory skin disorder characterized by recurrent eczematous lesions and persistent pruritus. Its pathogenesis involves epidermal barrier dysfunction, immune dysregul

X Xin Luo

High-dose vs. standard-dose influenza vaccine in heart failure: the FLUNITY-HD trial

No abstractEur Heart J. 2026 Aug 29:ehag709. doi: 10.1093/eurheartj/ehag709. Online ahead of print.NO ABSTRACTPMID:42667303 | DOI:10.1093/eurheartj/ehag709

N Niklas Dyrby Johansen

Microplastics in bottled water and human health outcomes: a systematic review of multi-organ toxicity and mechanistic pathways

J Environ Sci Health C Toxicol Carcinog. 2026 Aug 29:1-21. doi: 10.1080/26896583.2026.2722385. Online ahead of print.ABSTRACTThis systematic review synthesized evidence on the health effects of microplastic exposure, with emphasis on organ-specific toxicity, molecular mechanisms, and implications fo

R Rehoboth Chinyere Uwaga

Hydroxychloroquine-Induced Cardiotoxicity in the Setting of a False Positive PYP Scan

JACC Case Rep. 2026 Aug 29:109894. doi: 10.1016/j.jaccas.2026.109894. Online ahead of print.ABSTRACTBACKGROUND: Hydroxychloroquine (HCQ)-induced cardiomyopathy may mimic transthyretin cardiac amyloidosis on technetium-99m pyrophosphate (PYP) scans, producing false positive results. This diagnostic c

L Leonardo Wagner Florencio Dos Santos

Efficacy of Aficamten vs Metoprolol According to Pretrial Beta-Blocker Treatment in Obstructive Hypertrophic Cardiomyopathy: Insights From MAPLE-HCM

JACC Heart Fail. 2026 Aug 29:103352. doi: 10.1016/j.jchf.2026.103352. Online ahead of print.ABSTRACTBACKGROUND: The MAPLE-HCM trial demonstrated the superiority of monotherapy with aficamten vs metoprolol at improving clinical endpoints in obstructive hypertrophic cardiomyopathy (oHCM). The impact o

F Fernando Dominguez

Risk of Myocarditis and Pericarditis With Bivalent RSV Prefusion F Protein-Based Vaccine: A Safety Analysis of the Extended DAN-RSV Trial

No abstractJ Am Coll Cardiol. 2026 Aug 29:S0735-1097(26)07510-8. doi: 10.1016/j.jacc.2026.08.027. Online ahead of print.NO ABSTRACTPMID:42667277 | DOI:10.1016/j.jacc.2026.08.027

M Marat Yafasov

Development and external validation of the SCORE2 models in Latin America and the Caribbean (SCORE2-LAC) to estimate 10-year cardiovascular disease risk

Eur Heart J. 2026 Aug 29:ehag698. doi: 10.1093/eurheartj/ehag698. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Despite the high burden of cardiovascular disease (CVD) in Latin America and the Caribbean (LAC), risk prediction models adapted for use in LAC populations remain limited. The aim of

S Stella Bijkerk

Distribution and Clinical Utility of the Kidney Disease Improving Global Outcomes Chronic Kidney Disease Risk Classification in Patients Undergoing Atrial Fibrillation Ablation

J Am Heart Assoc. 2026 Aug 29:e049254. doi: 10.1161/JAHA.126.049254. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) is a key component of the cardiovascular-kidney-metabolic framework. However, in patients undergoing atrial fibrillation ablation, the distribution of CKD acros

H Hironori Ishiguchi

Retrospective Cohort Study of Peripheral Blood miR-486-3p Levels in Patients with Acute Cerebral Infarction and Obstructive Sleep Apnea Syndrome

J Vis Exp. 2026 Aug 28;(234). doi: 10.3791/72643.ABSTRACTAcute cerebral infarction (ACI) complicated with obstructive sleep apnea syndrome (OSAS) confers a high risk of stroke recurrence and death, yet effective biomarkers for this comorbid condition remain limited. This retrospective cohort study e

Z Zhihan Liu

Diagnosis and Treatment of Patent Foramen Ovale-associated Cryptogenic Stroke

J Vis Exp. 2026 Aug 28;(234). doi: 10.3791/72345.ABSTRACTPatent foramen ovale (PFO) is an important cause of cryptogenic stroke (CS), and its pathogenic mechanisms involve paradoxical embolism, in situ thrombus, hemodynamic changes caused by atrial remodeling, and high-risk anatomical features such

L Liju Liang