Brief Bioinform. 2026 May 4;27(3):bbag271. doi: 10.1093/bib/bbag271.ABSTRACTAccurate quantification of biological age is essential for early risk stratification and intervention of chronic diseases. Here, we present StackAge, an ensemble-based biological aging clock that integrates large-scale plasm
Autophagy. 2026 May 31:1-3. doi: 10.1080/15548627.2026.2679639. Online ahead of print.ABSTRACTCurrent Alzheimer's disease therapies offer limited efficacy and are often accompanied by significant side effects, underscoring the urgent need for new treatment strategies. Enhancing autophagy represents
Implement Sci Commun. 2026 May 30. doi: 10.1186/s43058-026-00977-0. Online ahead of print.ABSTRACTBACKGROUND: Although recommended, shared decision making (SDM) is not widely adopted for primary prevention of cardiovascular (CV) disease. Champions may influence peer adoption if they are enthusiastic
BMC Psychiatry. 2026 May 30. doi: 10.1186/s12888-026-08237-0. Online ahead of print.ABSTRACTBACKGROUND: Substance use disorder (SUD) is a debilitating neuropsychiatric condition characterized by persistent compulsive drug use and associated cognitive and psychiatric impairments. Emerging evidence su
BMC Med. 2026 May 30. doi: 10.1186/s12916-026-04946-1. Online ahead of print.ABSTRACTBACKGROUND: Optimization of HbA1c, blood pressure and cholesterol, referred to as the "ABCs", is central to the management of diabetes. However, the age-specific associations of these factors with mortality in patie
BMC Health Serv Res. 2026 May 30. doi: 10.1186/s12913-026-14815-5. Online ahead of print.ABSTRACTBACKGROUND: Dementia is frequently underdiagnosed in its early stages, but changes in healthcare utilization may precede diagnosis by several years. We examined healthcare patterns and chronic conditions
Cell Mol Biol Lett. 2026 May 30. doi: 10.1186/s11658-026-00954-4. Online ahead of print.ABSTRACTBACKGROUND: Atherosclerosis (AS)-associated cardiovascular disease is the main cause of global mortality. The excessive retention of glycated low-density lipoprotein (G-LDL) under the vascular endothelium
BMC Infect Dis. 2026 May 30. doi: 10.1186/s12879-026-13394-4. Online ahead of print.ABSTRACTBACKGROUND: Visceral leishmaniasis (VL) is an emerging infectious disease caused by the genus Leishmania and shares clinical features with some types of leukemia.METHODS: In a retrospective study (2020-2022),
Apoptosis. 2026 May 30;31(6):163. doi: 10.1007/s10495-026-02343-w.ABSTRACTThis study investigates the role and underlying mechanisms of total flavones of Rhododendron (TFR) in blood-brain barrier (BBB) disruption following transient bilateral common carotid artery occlusion-induced cerebral ischemia
J Racial Ethn Health Disparities. 2026 May 30. doi: 10.1007/s40615-026-03015-w. Online ahead of print.ABSTRACTBACKGROUND: Black birthing people face higher rates of severe maternal morbidity (SMM), a disparity that was exacerbated during the COVID-19 pandemic.METHODS: This study utilized secondary p
J Expo Sci Environ Epidemiol. 2026 May 30. doi: 10.1038/s41370-026-00919-x. Online ahead of print.ABSTRACTBACKGROUND: The United States (U.S.) currently lacks a Federal occupational heat standard and hot weather threatens the safety and health of farmworkers who often work under extreme heat conditi
Commun Med (Lond). 2026 May 30. doi: 10.1038/s43856-026-01694-4. Online ahead of print.ABSTRACTBACKGROUND: Pharmacological inhibition of sclerostin (SOST) is clinically applied to treat osteoporosis. However, large-scale randomized controlled trials have reported conflicting findings regarding the c
Commun Biol. 2026 May 30. doi: 10.1038/s42003-026-10375-w. Online ahead of print.ABSTRACTElephant populations are threatened by elephant endotheliotropic herpesvirus-hemorrhagic disease (EEHV-HD), a fast-acting infection that often kills very young elephants before they reach maturity. Because it st
Commun Med (Lond). 2026 May 30. doi: 10.1038/s43856-026-01684-6. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular disease (CVD) mortality is rising in Sierra Leone, but the health-system drivers of this trend are not well characterised. We mapped health-system barriers and facilitators for C
Sci Rep. 2026 May 30. doi: 10.1038/s41598-026-55482-0. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is an escalating global public health concern, with a rapidly increasing burden in low- and middle-income countries, including Bangladesh. Despite its growing prevalence and associated complic
Sci Rep. 2026 May 30. doi: 10.1038/s41598-026-55493-x. Online ahead of print.ABSTRACTInterleukin-17A (IL-17A) is a key cytokine in inflammation and autoimmunity. However, its systemic correlates, particularly in a high HIV burden population, are not fully elucidated. This study aimed to identify the
Sci Rep. 2026 May 30. doi: 10.1038/s41598-026-51080-2. Online ahead of print.ABSTRACTCoronary heart disease (CHD) and diabetes mellitus frequently co-occur through shared mechanisms such as oxidative stress and inflammation. Whether specific dietary antioxidants mitigate CHD-diabetes comorbidity rem
Cell Death Dis. 2026 May 30. doi: 10.1038/s41419-026-08930-8. Online ahead of print.ABSTRACTEndothelial dysfunction plays a key role in the development of diabetic cardiomyopathy (DCM), but the underlying mechanisms of endothelial dysfunction remain to be elucidated. Recent studies have revealed tha
CONCLUSIONS: While all patients achieved serum fT > MIC targets for CTZ and AMC (100% for AMC(bolus) and 89% for AMC(continuous)), target attainment in tissue was substantially lower. These findings suggest that although serum pharmacodynamic targets are reliably achieved, tissue exposure remains su
Exp Physiol. 2026 May 30. doi: 10.1113/EP092848. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is a leading cause of mortality in women, and CVD risk is accelerated during the menopause transition. This acceleration has traditionally been attributed to the hallmark decline in oestradiol
Nutr Metab Cardiovasc Dis. 2026 Apr 30:104775. doi: 10.1016/j.numecd.2026.104775. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: The Cardiovascular-Kidney-Metabolic (CKM) syndrome proposed by the American Heart Association (AHA) has been validated for mortality risk stratification in limited pop
Eur J Intern Med. 2026 May 8:106860. doi: 10.1016/j.ejim.2026.106860. Online ahead of print.ABSTRACTBACKGROUND: Real-world uptake of guideline-directed medical therapy (GDMT) at hospital discharge and clinical predictors of complete decongestion in acute heart failure (AHF) populations remain insuff
J Oral Biosci. 2026 Jun;68(3):100779. doi: 10.1016/j.job.2026.100779. Epub 2026 Mar 31.ABSTRACTBACKGROUND: Formalin-fixed paraffin-embedded (FFPE) samples are widely used for pathological diagnosis because they enable histological evaluation, special staining, and immunohistochemistry. The advent of
Handb Clin Neurol. 2026;218:271-287. doi: 10.1016/B978-0-443-22212-2.00014-8.ABSTRACTRetinal vein occlusion (RVO) is the second most common retinal vascular disease after diabetic retinopathy and can result in significant vision loss and ocular morbidity. Vision loss may result from hemorrhages, mac
