Br J Cancer. 2026 Jun 2. doi: 10.1038/s41416-026-03484-0. Online ahead of print.ABSTRACTBACKGROUND: Germ cell tumors (GCTs) are highly curable, yet a subset of patients with metastatic disease experience early death (ED) soon after starting first-line chemotherapy. These patients are underrepresente
Nat Cardiovasc Res. 2026 Jun 2. doi: 10.1038/s44161-026-00819-1. Online ahead of print.ABSTRACTCoronary microvascular disease (CMVD) contributes to the large burden of ischemic heart disease (IHD), and there is a need for mechanistic insight and targeted therapies. Perfusion cardiac PET allows for t
Sci Rep. 2026 Jun 2. doi: 10.1038/s41598-026-54182-z. Online ahead of print.ABSTRACTAutomated segmentation of cardiac magnetic resonance (CMR) imaging is integrated into clinical workflows, yet comparative performance across vendor AI solutions remains insufficiently characterized. This study assess
Sci Rep. 2026 Jun 3. doi: 10.1038/s41598-026-50941-0. Online ahead of print.ABSTRACTReal-world evidence on 12-month outcomes of guselkumab (GUS) in psoriatic arthritis (PsA) remains limited. This multicenter observational study aimed to identify predictors of 12-month DAPSA remission (DAPSA < 4) in
J Hum Hypertens. 2026 Jun 2. doi: 10.1038/s41371-026-01170-5. Online ahead of print.ABSTRACTAcute psychological stress may contribute to cardiovascular disease risk through transient vascular dysfunction. In a randomized crossover study of healthy young adults, the Trier Social Stress Task increased
J Hum Hypertens. 2026 Jun 2. doi: 10.1038/s41371-026-01163-4. Online ahead of print.ABSTRACTResistant hypertension in chronic kidney disease (CKD) remains a high-risk clinical phenotype associated with poor blood pressure (BP) control, accelerated kidney disease progression, and excess cardiovascula
NPJ Cardiovasc Health. 2026 Jun 2. doi: 10.1038/s44325-026-00131-8. Online ahead of print.ABSTRACTCardiovascular disease (CVD) remains the leading cause of morbidity and mortality in women, yet remains under-studied and under-recognised. Pregnancy acts as a 'cardiovascular stress test', with haemody
No abstractNat Rev Endocrinol. 2026 Jun 2. doi: 10.1038/s41574-026-01268-3. Online ahead of print.NO ABSTRACTPMID:42230790 | DOI:10.1038/s41574-026-01268-3
Nat Med. 2026 Jun 2. doi: 10.1038/s41591-026-04407-5. Online ahead of print.ABSTRACTSmaller quasi-experimental studies and short-term controlled trials of medically tailored meals (MTMs) have shown health benefits for several conditions, but MTMs have not been evaluated in large-scale policy initiat
Sci Data. 2026 Jun 2. doi: 10.1038/s41597-026-07550-3. Online ahead of print.ABSTRACTPrecise delineation of hepatic and portal venous anatomy is crucial for the diagnosis of liver disease, surgical planning, and prognosis prediction. Current three-dimensional visualization of these complex vascular
NPJ Genom Med. 2026 Jun 2;11(1):30. doi: 10.1038/s41525-026-00582-z.ABSTRACTSeveral studies have demonstrated the value of large-scale human exome and genome data analysis to maximise gene discovery in rare diseases. Using this approach, we have analysed the exomes of 4747 cases and 52,881 controls
Nat Commun. 2026 Jun 3. doi: 10.1038/s41467-026-73660-6. Online ahead of print.ABSTRACTThe mechanisms connecting the human fat depots, subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), to metabolic dysfunction-associated steatotic liver disease (MASLD) remain elusive. We hypothesi
Nat Commun. 2026 Jun 2. doi: 10.1038/s41467-026-72666-4. Online ahead of print.ABSTRACTSingle-cell RNA sequencing enables high-resolution analysis of cellular heterogeneity, yet disentangling biological signal from batch effects remains challenging. Existing batch-correction algorithms suppress or d
Signal Transduct Target Ther. 2026 Jun 2;11(1):208. doi: 10.1038/s41392-026-02665-w.ABSTRACTAutism spectrum disorders (ASD) affect approximately 1.0% of children worldwide with still increasing global prevalence. The fact that genetic factors contribute to less than 50% of ASD suggests some critical
Signal Transduct Target Ther. 2026 Jun 3;11(1):210. doi: 10.1038/s41392-026-02631-6.ABSTRACTThe integration of multiomics technologies with artificial intelligence (AI) has become a transformative force in modern precision medicine, particularly within drug discovery. Multiomics approaches, includin
Transl Psychiatry. 2026 Jun 2. doi: 10.1038/s41398-026-04137-9. Online ahead of print.ABSTRACTMajor depression (MD) treatments have limited efficacy and target few mechanisms, highlighting the need for innovative drug discovery. Drugs targeting genetically supported proteins are 2.6 times more likel
Esophagus. 2026 Jun 2. doi: 10.1007/s10388-026-01214-2. Online ahead of print.ABSTRACTBACKGROUND: To confirm the accurate pN0 status in patients with cT1-2N0 esophageal squamous cell carcinoma (ESCC) and recommend an optimal lymph node (LN) count for accurate nodal staging.METHODS: A total of 1855 p
Dig Dis Sci. 2026 Jun 2. doi: 10.1007/s10620-026-10033-5. Online ahead of print.ABSTRACTPURPOSE: People with metabolic dysfunction-associated steatotic liver disease (MASLD) or alcohol-related liver disease (ALD) are at increased risk of cardiovascular (CV) events and extrahepatic cancers. However,
AAPS J. 2026 Jun 2;28(4):114. doi: 10.1208/s12248-026-01261-8.ABSTRACTThe pathogenesis of cancer represents a multifaceted, progressive process driven by an intricate interplay of physical, chemical, biological, and other etiological factors. Recent advancements in clinical oncology, including targe
Inn Med (Heidelb). 2026 Jun 2. doi: 10.1007/s00108-026-02138-w. Online ahead of print.ABSTRACTBACKGROUND: Rheumatoid arthritis (RA) is a common chronic inflammatory disease and a systemic autoimmune disorder associated with increased morbidity and mortality due to multiorgan involvement.OBJECTIVES:
Br J Nutr. 2026 Jun 3:1-33. doi: 10.1017/S0007114526107661. Online ahead of print.ABSTRACTMicronutrient deficiencies are modifiable risk factors for cardiovascular disease (CVD), yet their relative importance and combined effects across populations require further characterization.We performed a bin
Eur Heart J Cardiovasc Imaging. 2026 Jun 2:jeag135. doi: 10.1093/ehjci/jeag135. Online ahead of print.ABSTRACTAIM: To evaluate the prognostic value of cardiac magnetic resonance (CMR) feature tracking-derived left ventricular global longitudinal strain (FT-LVGLS) for adverse outcomes in patients wit
J Clin Lipidol. 2026 Apr 20:S1933-2874(26)00119-4. doi: 10.1016/j.jacl.2026.04.016. Online ahead of print.ABSTRACTBACKGROUND: Lower extremity peripheral arterial disease (PAD) is a prevalent manifestation of systemic atherosclerosis associated with significant morbidity, mortality, and economic burd
Cardiovasc Revasc Med. 2026 May 23:S1553-8389(26)00201-0. doi: 10.1016/j.carrev.2026.05.007. Online ahead of print.ABSTRACTBACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) is widely used for risk stratification in patients presenting with suspected non-ST-elevation acute coronary syndrome (
