JAMA Netw Open. 2026 May 1;9(5):e2611892. doi: 10.1001/jamanetworkopen.2026.11892.ABSTRACTIMPORTANCE: Female patients with heart failure (HF) are older and more often present with preserved left ventricular ejection fraction (LVEF), whereas male patients present with more ischemic disease. Despite t
Neth Heart J. 2026 May 12. doi: 10.1007/s12471-026-02048-4. Online ahead of print.ABSTRACTBACKGROUND: Aortic regurgitation (AR) is the third most common valvular heart disease in the Western world. Management of high-surgical-risk patients is challenging. The absence of calcifications in the aortic
Immunol Res. 2026 May 12;74(1):54. doi: 10.1007/s12026-026-09772-4.ABSTRACTThis study aims to investigate the prevalence, clinical characteristics, and prognostic significance of anti-neutrophil cytoplasmic antibodies (ANCA) across different subtypes of interstitial lung disease (ILD), specifically
Intern Emerg Med. 2026 May 12. doi: 10.1007/s11739-026-04369-z. Online ahead of print.ABSTRACTIn patients presenting with acute coronary syndrome (ACS) and multivessel disease, it is unclear whether non-culprit lesions should be revascularized immediately or in a staged procedure. We performed a met
Heart Fail Rev. 2026 May 12;31(1):65. doi: 10.1007/s10741-026-10622-6.ABSTRACTHeart failure (HF) has a significant impact on quality of life and employment. For patients with HF of work age, return to work (RTW) is an important goal because of its social and economic significance. This scoping revie
Surg Today. 2026 May 12. doi: 10.1007/s00595-026-03309-w. Online ahead of print.ABSTRACTPURPOSE: To evaluate the safety and efficacy of sleeve lobectomy for patients with non-small cell lung cancer (NSCLC) and assess the prognostic impact of preoperative chemoradiotherapy.METHODS: The subjects of th
Cell Mol Life Sci. 2026 May 12. doi: 10.1007/s00018-026-06191-4. Online ahead of print.ABSTRACTPeroxisomes are small, highly dynamic organelles involved in a plethora of metabolic pathways. They are essential for the efficient exchange of metabolites and cellular messengers orchestrating intracellul
Eur J Clin Invest. 2026 May;56(5):e70213. doi: 10.1111/eci.70213.ABSTRACTSingle-cell analysis of human heart failure identifies a fibroblast-enriched ferroptosis signature that distinguishes DCM from controls and reveals a pseudotime trajectory linking ferroptotic stress to progressive fibroblast ac
Radiol Med. 2026 May 12. doi: 10.1007/s11547-026-02200-5. Online ahead of print.ABSTRACTPURPOSE: Several semiquantitative coronary computed tomography angiography (CCTA) scores including different parameters describing stenosis degree, plaque burden and plaque features have been developed for diagno
Adv Sci (Weinh). 2026 May 12:e75609. doi: 10.1002/advs.75609. Online ahead of print.ABSTRACTClass Switch Recombination (CSR) is essential for generating high-affinity antibody isotypes from IgM during adaptive humoral responses. Despite well-established roles for various transcription factors, wheth
Clin Transl Sci. 2026 May;19(5):e70595. doi: 10.1111/cts.70595.ABSTRACTDoxorubicin (DOX) is an effective chemotherapeutic agent; however, its use is limited by dose-dependent cardiotoxicity, which is challenging to detect early with current biomarkers such as NT-proBNP. Growth differentiation factor
Kardiol Pol. 2026 May 12. doi: 10.33963/v.phj.112319. Online ahead of print.ABSTRACTPercutaneous coronary intervention in patients with calcified coronary artery disease which is present in approximately 20% of those undergoing invasive treatment, is associated with poor clinical outcomes. Despite i
Nephrol Dial Transplant. 2026 May 12:gfag107. doi: 10.1093/ndt/gfag107. Online ahead of print.ABSTRACTCoffee is one of the most widely consumed beverages globally. Caffeine has been linked to antioxidant, anti-inflammatory, antifibrotic, and anticancer effects. However, the relationship between caff
Echocardiography. 2026 May;43(5):e70496. doi: 10.1111/echo.70496.ABSTRACTOBJECTIVES: Coronary microvascular dysfunction (CMD) has been increasingly acknowledged as an important contributor to myocardial ischemia and unfavorable cardiovascular outcomes. However, whether CMD is associated with impairm
Echocardiography. 2026 May;43(5):e70472. doi: 10.1111/echo.70472.ABSTRACTPURPOSE: Accurate quantification of ventricular volumes and function is critical for managing congenital heart disease (CHD) and guiding surgical and interventional decisions. Although cardiac magnetic resonance imaging (CMR) a
Biology (Basel). 2026 Apr 28;15(9):691. doi: 10.3390/biology15090691.ABSTRACTEpoxide hydrolases (EHs) constitute a conserved enzyme family that catalyzes the hydrolysis of epoxides into less reactive diols. Beyond their canonical roles in xenobiotic detoxification, EHs have emerged as critical regul
FASEB J. 2026 May 31;40(10):e71880. doi: 10.1096/fj.202600264R.ABSTRACTDiabetic retinopathy (DR), a prominent microvascular impairment arising from diabetes, causes substantial visual dysfunction. Emerging evidence indicates that intestinal dysbiosis promotes DR progression via the gut-retina axis.
Health Technol Assess. 2026 May;30(31):1-64. doi: 10.3310/LAKP6585.ABSTRACTBACKGROUND: Return to work is achieved by < 50% stroke survivors. Evidence on support for return to work is lacking.OBJECTIVE: To determine whether Early Stroke Specialist Vocational Rehabilitation is more clinically effectiv
FASEB J. 2026 May 15;40(9):e71887. doi: 10.1096/fj.202600972R.ABSTRACTLiver fibrosis is both a pathological feature and an instigator/promoter of chronic liver disease. Hepatic stellate cells (HSCs), by trans-differentiating into myofibroblasts, are the principal mediator of liver fibrosis. In the p
Clin Cardiol. 2026 May;49(5):e70350. doi: 10.1002/clc.70350.ABSTRACTBACKGROUND: Percutaneous coronary intervention (PCI) is an important treatment for coronary artery disease (CAD). Distal transradial access (dTRA) has gained popularity as an alternative to conventional transradial access (TRA) in c
J Vet Intern Med. 2026 May 4;40(3):aalag079. doi: 10.1093/jvimsj/aalag079.ABSTRACTBACKGROUND: Information on the classical and alternative circulating renin-angiotensin-aldosterone systems (RAAS) in cats with non-hypertensive chronic kidney disease (NHT-CKD) or systemic arterial hypertension (SAH) i
J Spinal Cord Med. 2026 May 12:1-11. doi: 10.1080/10790268.2026.2630501. Online ahead of print.ABSTRACTBACKGROUND: Spinal cord injury (SCI) above the sixth thoracic segment (≥T6) often causes daily blood pressure (BP) fluctuations, increasing cardiovascular disease (CVD) risk.OBJECTIVE: To investiga
J Investig Med High Impact Case Rep. 2026 Jan-Dec;14:23247096261452328. doi: 10.1177/23247096261452328. Epub 2026 May 12.ABSTRACTLemierre's syndrome is a rare postanginal septic thrombophlebitis involving the internal jugular vein in younger adults. Extension into the thoracic inlet and upper extrem
Acta Radiol. 2026 May 12:2841851261445322. doi: 10.1177/02841851261445322. Online ahead of print.ABSTRACTBackgroundAtherosclerosis is a systemic disease that usually affects multi-vascular beds, and high-risk atherosclerotic plaques (HRPs) are associated with ischemic events.PurposeTo investigate th
