NLRP3 Inflammasome Activation and Atherogenic Lipid Profile in Hemodialysis Patients

Ther Apher Dial. 2026 May 17. doi: 10.1002/1744-9987.70158. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: End-stage renal disease (ESRD) patients who undergo hemodialysis treatment experience accelerated atherosclerosis development, which results from two main causes: atherogenic dyslipidemia a

M Mohammed N Abdelaziz

Genetics of Response to Canagliflozin (GRC) Study: Rationale, Design, and Pharmacodynamic Responses

Clin Transl Sci. 2026 Jun;19(6):e70594. doi: 10.1111/cts.70594.ABSTRACTSodium glucose cotransporter-2 (SGLT2) inhibitors are a class of antidiabetics with benefits including HbA1c-lowering, weight loss, cardiovascular and renal protection in addition to adverse effects including genitourinary tract

M May E Montasser

The diagnostic value and mechanistic role of miR-20b-5p in premature coronary artery disease

Ir J Med Sci. 2026 May 18. doi: 10.1007/s11845-026-04443-7. Online ahead of print.ABSTRACTBACKGROUND: Premature coronary artery disease (PCAD) is marked by accelerated progression of atherosclerosis, an increased incidence of adverse cardiovascular events, and a less favorable long-term prognosis.AI

S Shizhao Hou

LEP Knockdown Improves Functional Recovery After Spinal Cord Injury and Potentially Regulates Microglial Polarization via JAK-STAT Signaling Pathway

Neuromolecular Med. 2026 May 17;28(1):27. doi: 10.1007/s12017-026-08930-z.ABSTRACTNeuroinflammation following spinal cord injury (SCI) is primarily driven by abnormal microglial activation and represents a major barrier to neurological recovery. This study aimed to investigate the regulatory role of

C Chun Chen

RDE-DR: robust deep ensemble CNNs for automated diabetic retinopathy detection from fundus images

Sci Rep. 2026 May 17;16(1):15226. doi: 10.1038/s41598-026-48669-y.ABSTRACTDiabetic retinopathy (DR) is a leading cause of preventable blindness, motivating the development of reliable automated screening systems. This work proposes a Robust Deep Ensemble for Diabetic Retinopathy detection (RDE-DR) b

I Ishaq Aiche

VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPKγ1 and preventing AMPKα-γ subunit assembly in cardiomyocytes

Signal Transduct Target Ther. 2026 May 18;11(1):185. doi: 10.1038/s41392-026-02701-9.ABSTRACTProtein ubiquitination modifications contribute to cardiomyocyte homeostasis and pathophysiology in diabetic cardiomyopathy (DCM). Yet the roles of deubiquitinating enzymes (DUBs) in DCM remain poorly define

X Xue Han

Eosinophilic Granulomatosis with Polyangiitis that Manifested after Administration of Benralizumab in a Patient with Refractory Recurrent Bronchial Asthma

Intern Med. 2026;65(10):1372-1376. doi: 10.2169/internalmedicine.6141-25.ABSTRACTA 73-year-old woman with bronchial asthma presented with a rash and peripheral neuropathy. Since 21 years old, her asthma had been treated with glucocorticoids. Benralizumab had been introduced six years ago, and glucoc

U Ukyo Yamamoto

Recurrent Focal-type Takotsubo Syndrome Following Prior Mid-ventricular Variant

Intern Med. 2026;65(10):1360-1364. doi: 10.2169/internalmedicine.6121-25.ABSTRACTWe report an extremely rare case of recurrent Takotsubo syndrome (TTS) in an 83-year-old woman who initially experienced the mid-ventricular type and later developed the focal type. TTS is a transient cardiac condition

T Takeshi Ishihara

Estimated Plasma Volume and Heart Failure-Related Events in Hospitalized Patients With Stage A-D Heart Failure

Circ J. 2026 May 16. doi: 10.1253/circj.CJ-25-1164. Online ahead of print.ABSTRACTBACKGROUND: Heart failure (HF) is associated with poor clinical outcomes and is classified into Stages A-D. Estimated plasma volume (ePV) is a marker of plasma volume expansion. Prognostic markers applicable across all

Y Yoichiro Otaki

A Literature Review on the Waist Circumference Criteria for Metabolic Syndrome in Japan: Evidence and Implications for Cardiovascular Risk Stratification

J Atheroscler Thromb. 2026 May 15. doi: 10.5551/jat.RV22051. Online ahead of print.ABSTRACTWaist circumference (WC) is widely used as a marker of central obesity in the diagnosis of metabolic syndrome (MetS) and it plays an important role in cardiovascular disease (CVD) risk screening. In Japan, the

T Tomoe Uchida

Small Molecules as Advanced Therapy for the Treatment of Inflammatory Bowel Disease, Particularly Regarding Ulcerative Colitis

Intern Med. 2026 May 16. doi: 10.2169/internalmedicine.7378-26. Online ahead of print.ABSTRACTSmall molecules used to treat inflammatory bowel disease (IBD) are orally administered therapies that offer a rapid onset without immunogenicity. Currently, three Janus kinase (JAK) inhibitors (tofacitinib,

T Toshiyuki Sakurai

Asymptomatic Pulmonary Involvement as the Initial Presentation of Vascular Ehlers-Danlos Syndrome with a Novel COL3A1 Frameshift Variant: A Case Report

Intern Med. 2026 May 16. doi: 10.2169/internalmedicine.7307-26. Online ahead of print.ABSTRACTVascular Ehlers-Danlos syndrome (vEDS), a rare connective tissue disorder caused by pathogenic COL3A1 variants, rarely presents with isolated pulmonary manifestations in asymptomatic cases. We herein report

H Hitomi Nogawa

A Delayed Progression of Porphyria-Associated Kidney Disease After Hemin Therapy in a Patient with Acute Intermittent Porphyria: A Case Report

Intern Med. 2026 May 16. doi: 10.2169/internalmedicine.7131-26. Online ahead of print.ABSTRACTAcute intermittent porphyria (AIP) is a condition characterized by the neurotoxic accumulation of δ-aminolevulinic acid and porphobilinogen. However, chronic kidney disease is an under-recognized complicati

T Takuya Ishimura

Clinical Characteristics of Dynapenia and Sarcopenia in Hospitalized Patients with Cardiovascular Disease

Int Heart J. 2026 May 16. doi: 10.1536/ihj.25-730. Online ahead of print.ABSTRACTDynapenia, defined as reduced muscle strength despite preserved muscle mass, is increasingly being recognized alongside sarcopenia in older adults. Clinical differences between dynapenia and sarcopenia in hospitalized c

K Keisuke Okano

Body Awareness Therapy in Peripheral Arterial Disease: A Randomized Controlled Trial

Pain Manag Nurs. 2026 May 17:S1524-9042(26)00162-1. doi: 10.1016/j.pmn.2026.04.023. Online ahead of print.ABSTRACTPURPOSE: This study examined the effects of adding body awareness therapy (BAT) to a standard exercise and lifestyle management program on pain, functional capacity, and psychosocial out

S Seda Karaca

Abdominal adiposity and accelerated biological ageing in relation to general and cardiovascular ageing in Chinese adults

Heart. 2026 May 17:heartjnl-2026-327950. doi: 10.1136/heartjnl-2026-327950. Online ahead of print.ABSTRACTBACKGROUND: Abdominal adiposity may contribute to both general and cardiovascular ageing, yet the extent to which accelerated biological age (BA) at distinct molecular levels mediates these effe

Z Zhiyu Wu

Yiqi Huoxue Lishui-based Optimized New Shengmai Powder ameliorates myocardial injury in rats with post-myocardial infarction heart failure by inhibiting oxidative stress-mediated ferroptosis via the cyclic guanosine monophosphate-protein kinase G-glutathione peroxidase 4 axis

J Ethnopharmacol. 2026 May 16:121798. doi: 10.1016/j.jep.2026.121798. Online ahead of print.ABSTRACTETHNOPHARMACOLOGICAL RELEVANCE: Yiqi Huoxue Lishui (tonifying qi, promoting blood circulation, and promoting diuresis to relieve water retention) is a core therapeutic principle in traditional Chinese

Z Zeyu Zhang

In Reply: Antithrombotic Strategies in Chronic Kidney Disease: The Importance of Exposure Definition and Temporal Alignment

No abstractMayo Clin Proc. 2026 May 16:S0025-6196(26)18537-1. doi: 10.1016/j.mayocp.2026.05.004. Online ahead of print.NO ABSTRACTPMID:42144186 | DOI:10.1016/j.mayocp.2026.05.004

C Chih-Chin Kao

When Death Pathways Converge: PANoptosis in the Evolution and Treatment of Female Tumors

Crit Rev Oncol Hematol. 2026 May 16:105380. doi: 10.1016/j.critrevonc.2026.105380. Online ahead of print.ABSTRACTPANoptosis represents a novel and integrated pro-inflammatory programmed cell death pathway, combining features of pyroptosis, apoptosis, and necroptosis. This review explores the emergin

L Lingjun Yao

Intracoronary Imaging for Percutaneous Coronary Intervention Guidance

Am J Cardiol. 2026 May 16:S0002-9149(26)00345-0. doi: 10.1016/j.amjcard.2026.05.014. Online ahead of print.ABSTRACTIntracoronary imaging (ICI) is an important adjunct to invasive coronary angiography for the assessment of lesion morphology and guidance of percutaneous coronary intervention (PCI). Ex

J Jaskanwal Deep S Sara

Outcomes of Early Sodium-Glucose Cotransporter 2 Inhibitor Use in Takotsubo Syndrome: Insights from a Multicenter Real-World Cohort Study

Am J Cardiol. 2026 May 16:S0002-9149(26)00342-5. doi: 10.1016/j.amjcard.2026.05.012. Online ahead of print.ABSTRACTBACKGROUND: Pharmacologic management after Takotsubo syndrome remains empirical.OBJECTIVES: We evaluated whether early sodium-glucose cotransporter-2 inhibitor initiation after Takotsub

A Amro Taha

Prevalence, trends, and determinants of early-onset type 2 diabetes in northwest China: a sex-stratified analysis of ∼10 million community-dwelling population

Diabetes Res Clin Pract. 2026 May 16:113324. doi: 10.1016/j.diabres.2026.113324. Online ahead of print.ABSTRACTPURPOSE: To investigate the trends and sex-specific risk factors of early-onset type 2 diabetes in northwest China.METHODS: Using the Northwest China Tianshan Cohort (2019-2023; ∼10 million

J Juan Wang

Research on Carotid Blood Flow Detection Based on Interferometric Diffuse Speckle Contrast Analysis and Its Application in Preventing Ischemic Stroke

J Biophotonics. 2026 May;19(5):e70277. doi: 10.1002/jbio.70277.ABSTRACTThis study applied the Interferometric Diffusion Speckle Contrast Analysis (iDSCA) system developed by our research group to detect changes in common carotid artery blood flow. Through animal experiments combining color Doppler u

G Guang Han

Structural optimization of cholesteryl ester transfer protein inhibitors: From early scaffolds to advanced clinical candidates

Eur J Med Chem. 2026 May 8;315:118920. doi: 10.1016/j.ejmech.2026.118920. Online ahead of print.ABSTRACTCholesteryl ester transfer protein has been a long-sought target for the treatment of dyslipidemia because of its prime function in the remolding of lipoprotein particles and the reverse transport

M Mahla Abdollahzadeh