Harnessing phytochemicals for engineering health solutions

Hum Genomics. 2026 Jan 22. doi: 10.1186/s40246-025-00882-y. Online ahead of print.ABSTRACTThe interaction between the genome and the exposome is increasingly recognized as central to human health and disease. While exposome research has generally focused on adverse exposures such as pollutants and t

J Jenny Ji Hyun Kim

Altitude hypoxia and hypoxemia: pathogenesis and management

Signal Transduct Target Ther. 2026 Jan 23;11(1):27. doi: 10.1038/s41392-025-02531-1.ABSTRACTAt high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which lea

C Chunmei Cai

Factors influencing the decision to accept or decline aortic valve replacement for asymptomatic aortic stenosis: a nested longitudinal qualitative substudy of the EASY-AS randomised trial

BMJ Open. 2026 Jan 22;16(1):e106485. doi: 10.1136/bmjopen-2025-106485.ABSTRACTOBJECTIVE: To examine how patients and family members decide whether to accept a highly invasive intervention (aortic valve replacement (AVR)) when their condition (aortic stenosis (AS)) is asymptomatic and its course unce

P Peter Allmark

Effect of 12 weeks with a 30-min nap opportunity during the night shift of healthcare workers on early cardiovascular risk biomarkers: the NAPWORK study protocol of a randomised controlled trial

BMJ Open. 2026 Jan 22;16(1):e110108. doi: 10.1136/bmjopen-2025-110108.ABSTRACTBACKGROUND: Night shift work is well known to cause health disruption in the short and long term. Among healthcare workers, sleep deprivation is a common concern with many nurses reporting sleep of <6 hour per 24-hour peri

Y Yanis Bouchou

Unusual association: Sturge-Weber syndrome with Klippel-Trenaunay syndrome

BMJ Case Rep. 2026 Jan 22;19(1):e269990. doi: 10.1136/bcr-2025-269990.ABSTRACTSturge-Weber syndrome (SWS) and Klippel-Trenaunay syndrome (KTS) are rare vascular malformation disorders characterised by distinct clinical features but overlapping pathogenic mechanisms, involving somatic mosaic mutation

V Vykuntaraju K Gowda