Timing of Antidiabetic Medication Initiation and Risk of Cardiovascular Events and Mortality

JAMA Netw Open. 2026 Jun 1;9(6):e2619362. doi: 10.1001/jamanetworkopen.2026.19362.ABSTRACTIMPORTANCE: Among individuals who meet the diagnostic threshold for type 2 diabetes (T2D), timely initiation of antidiabetic medication (ADM) is essential for lowering long-term cardiovascular risk.OBJECTIVE: T

H Hwa Yeon Ko

Multilevel Stewardship Intervention for Use of Anticoagulation-Antiplatelet Therapy

JAMA Intern Med. 2026 Jun 22. doi: 10.1001/jamainternmed.2026.2036. Online ahead of print.ABSTRACTIMPORTANCE: Antiplatelet medications are overprescribed in patients taking direct oral anticoagulants (DOACs), increasing their risk of major bleeding. The utility of potentially scalable antithrombotic

J Jacob E Kurlander

Left Ventricular Thrombus in Ischemic Heart Failure: Machine-learning-based Prediction of Six-month Persistence and One-year Outcomes

J Cardiovasc Transl Res. 2026 Jun 22;19(1):75. doi: 10.1007/s12265-026-10804-5.ABSTRACTLeft ventricular thrombus (LVT) in ischemic heart failure carries embolic risk; tools to anticipate persistence are limited. We studied 190 consecutive patients with imaging-confirmed LVT managed with guideline-co

Y Yunus Emre Yavuz

Resting heart rate and cognitive function in ageing: Insights from a secondary data analysis

Geroscience. 2026 Jun 22. doi: 10.1007/s11357-026-02364-y. Online ahead of print.ABSTRACTResting heart rate (RHR) is an accessible measure that may reflect age-related cardiovascular and autonomic dysregulation relevant to cognitive ageing. However, evidence linking RHR with cognitive outcomes is in

Y Yunrui Gu

Review: natural compounds as PCSK9 inhibitors for antiviral therapy

Arch Microbiol. 2026 Jun 22;208(9):453. doi: 10.1007/s00203-026-05006-1.ABSTRACTFrom the perspective of both the host cell and the virus, cholesterol (CHO) plays a critical role during viral infection. Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases the risk of cardiovascular disease

R Radhwan Abdul Kareem

ALIGNED Network for rare cerebrovascular diseases: methodology and preliminary results

Neurol Sci. 2026 Jun 22;47(7):584. doi: 10.1007/s10072-026-09183-1.ABSTRACTINTRODUCTION: Cerebrovascular diseases are a major cause of morbidity/mortality worldwide, yet more than 30% of strokes remain of undetermined origin. Rare cerebrovascular diseases (rCVDs) contribute to this burden but are of

C Carolina De Toma

Mortality and survival in patients with systemic lupus erythematosus in the Middle East and North Africa: a systematic review and meta-analysis

Rheumatol Int. 2026 Jun 22;46(7):161. doi: 10.1007/s00296-026-06181-6.ABSTRACTSystemic lupus erythematosus (SLE) is associated with increased mortality compared with the general population, with outcomes influenced by ethnicity and organ involvement. Data from the Middle East and North Africa (MENA)

S Samar Alharbi

Methylmalonic acid as a ferroptosis-derived danger signal: activation of the PI3K-NF-κB pathway drives M1 macrophage polarization in renal ischemia-reperfusion injury

Inflamm Res. 2026 Jun 22;75(1):153. doi: 10.1007/s00011-026-02300-y.ABSTRACTBACKGROUND: Ferroptosis and macrophage activation are key contributors to the development of acute kidney injury (AKI). Ferroptosis is accompanied by metabolic reprogramming and the release of soluble mediators, including me

H Huimeng Wang

Revascularization with drug-coated balloons alone in complex coronary artery disease: a systematic review

Clin Res Cardiol. 2026 Jun 22. doi: 10.1007/s00392-026-02957-9. Online ahead of print.ABSTRACTBACKGROUND: Drug-coated balloon (DCB) therapy has emerged as an alternative to stent-based treatment in coronary artery disease (CAD), particularly in patients where a "leave-nothing-behind" approach may be

M Michael Kunz

Improving Global Air-Quality Indices - The WHO's New Roadmap

No abstractN Engl J Med. 2026 Jun 20. doi: 10.1056/NEJMp2601256. Online ahead of print.NO ABSTRACTPMID:42329391 | DOI:10.1056/NEJMp2601256

R Robert D Brook

A rare bilateral spontaneous severe hemothorax in intramural hematoma type B with unremarkable aortic histology: a case report and literature review

Forensic Sci Med Pathol. 2026 Jun 22. doi: 10.1007/s12024-026-01302-w. Online ahead of print.ABSTRACTAortic intramural hematoma type B (IMHB) is a serious aortic condition characterized by crescentic thickening of the descending aorta, resulting from hemorrhage within the aortic wall, which may occa

S Silvia Farkašová Iannaccone

Development and validation of a multimodal machine learning prediction model for heart failure after acute myocardial infarction

Clin Exp Med. 2026 Jun 22. doi: 10.1007/s10238-026-02230-3. Online ahead of print.ABSTRACTHeart failure after acute myocardial infarction (post-MI HF) has become a major global health problem. Accurate risk prediction is essential for optimising management and preventing post-MI HF. However, existin

X Xiaojun Wu

Super learner model for predicting carotid plaque regression in type 2 diabetes on PCSK9 inhibitors

Acta Diabetol. 2026 Jun 22. doi: 10.1007/s00592-026-02729-x. Online ahead of print.ABSTRACTOBJECTIVES: Evidence regarding the effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on carotid plaque regression in patients with type 2 diabetes mellitus (T2DM) and subclinical athe

J Jingyao Chen

Emerging T-Cell Engagers and Novel Immunotargets in Multiple Myeloma

Oncology (Williston Park). 2026 May 29;40(4). doi: 10.46883/2026.25921166.ABSTRACTBACKGROUND: Bispecific T-cell engagers (BiTEs) and chimeric antigen receptor (CAR) T-cell therapies have transformed the management of hematologic malignancies, including relapsed/refractory multiple myeloma (RRMM), ly

C Carmel Awadallah

Let there be light - when it's needed

No abstractEur J Prev Cardiol. 2026 Jun 22:zwag331. doi: 10.1093/eurjpc/zwag331. Online ahead of print.NO ABSTRACTPMID:42329214 | DOI:10.1093/eurjpc/zwag331

P Pedro Marques-Vidal

The Lifestyle Medicine Health Behavior Scale and Cardiovascular Disease: A Prospective Cohort Study From the UK Biobank

Am J Prev Med. 2026 May 28:108416. doi: 10.1016/j.amepre.2026.108416. Online ahead of print.ABSTRACTINTRODUCTION: Cardiovascular disease remains the leading cause of death globally, with modifiable lifestyle factors being paramount in its prevention. However, comprehensive tools to evaluate adherenc

M Mercedes Sotos-Prieto

Acoramidis for the management of transthyretin amyloid cardiomyopathy: Clinical evidence and implications for pharmacist-led care

Am J Health Syst Pharm. 2026 Jun 22:zxag181. doi: 10.1093/ajhp/zxag181. Online ahead of print.ABSTRACTPURPOSE: To provide an overview of the manifestation and diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) and the treatment option acoramidis, including its pharmacology and clinical tria

J Joseph S Van Tuyl

Do the treatment selection factors emphasized in clinical guidelines-Chronic kidney disease, cardiovascular disease, and heart failure-contribute to the risk of urinary tract infections during the administration of sodium-glucose cotransporter-2 inhibitors?

J Diabetes Investig. 2026 Jun 22. doi: 10.1111/jdi.70362. Online ahead of print.ABSTRACTAIMS/INTRODUCTION: Sodium-glucose cotransporter-2 inhibitors (SGLT2Is) are recommended in Japan for patients with cardiovascular disease (CVD), heart failure (HF), or chronic kidney disease (CKD) due to their org

T Takuma Koinuma

Accelerometer-Derived Moderate-to-Vigorous Physical Activity and the Risk of Four Common Vision-Threatening Ocular Diseases

Transl Vis Sci Technol. 2026 Jun 1;15(6):24. doi: 10.1167/tvst.15.6.24.ABSTRACTPURPOSE: The purpose of this study was to investigate the association between accelerometer-derived moderate-to-vigorous physical activity (MVPA) and four common vision-threatening ocular diseases: cataract, diabetic reti

R Rong Zhang

Unveiling novel susceptibility genes for sarcoidosis by a cross-tissue transcriptome-wide association study

Sarcoidosis Vasc Diffuse Lung Dis. 2026 Jun 22;43(2):18029. doi: 10.36141/svdld.2026.18029.ABSTRACTBACKGROUND: Sarcoidosis is a systemic granulomatous disease with heterogeneous clinical manifestations and unclear pathogenesis. Although genome-wide association studies (GWAS) have identified several

X Xiqiao Sun

Survival Improvement With Steroid Use for Pulmonary Veno-Occlusive Disease With the Aid of Pulmonary Vasodilators and Tyrosine-Kinase Inhibitor, a Retrospective Study

Clin Cardiol. 2026 Jun;49(6):e70379. doi: 10.1002/clc.70379.ABSTRACTBACKGROUND: Steroids are effective in patients with heart failure, connective tissue disease, and interstitial lung disease, which are conditions often associated with Pulmonary veno-occlusive disease (PVOD). This study assessed the

M Mayumi Finger

Pathogenetic and clinical aspects of fibromyalgia: one year in review 2026

Clin Exp Rheumatol. 2026 Jun;44(6):1057-1068. doi: 10.55563/clinexprheumatol/asx3uo. Epub 2026 Jun 18.ABSTRACTFibromyalgia (FM) is a complex chronic pain condition with a multifaceted pathogenesis and heterogeneous clinical presentation. This narrative review summarises the most relevant studies pub

C Cristina Iannuccelli

Oxygen-ozone autohaemotherapy in fibromyalgia: safety profile and adverse events. A scoping review

Clin Exp Rheumatol. 2026 Jun;44(6):1199-1207. doi: 10.55563/clinexprheumatol/l4g4nf. Epub 2026 Jun 22.ABSTRACTOBJECTIVES: Oxygen-ozone autohaemotherapy (O2-O3-AHT) has gained clinical interest as an adjunctive treatment for fibromyalgia (FM) based on its anti-inflammatory and anti-oxidative properti

R Roberto Casale

APOE*4 risk-modifying genes and drug targets in Alzheimer's disease through cell-type-specific genomic analyses

Alzheimers Dement. 2026 Jun;22(6):e71552. doi: 10.1002/alz.71552.ABSTRACTINTRODUCTION: Genetics studies can identify drug targets that counteract the effects of the apolipoprotein E ε4 allele (APOE*4) on Alzheimer's disease (AD) but have remained limited in power and crucially did not assess genetic

Y Youjie Zeng