Inherited Thrombophilia in Early-Onset Carotid Stenosis: A Comparative Study of Dissection, Atherosclerosis, Fibromuscular Dysplasia, and Other Etiologies

Clin Appl Thromb Hemost. 2025 Jan-Dec;31:10760296251401577. doi: 10.1177/10760296251401577. Epub 2025 Nov 25.ABSTRACTBackgroundCarotid artery stenosis is a recognized cause of ischemic stroke in older adults but is rare in individuals under 50, where distinct etiologies such as dissection, fibromusc

E Ebru Marzioglu Ozdemir

Validation of a Risk Score for Cancer-Associated Thrombosis Using Nationwide EHR Data

JAMA Netw Open. 2025 Nov 3;8(11):e2544428. doi: 10.1001/jamanetworkopen.2025.44428.ABSTRACTIMPORTANCE: Venous thromboembolism (VTE) is associated with increased mortality and morbidity in patients with cancer. Existing risk prediction models are typically validated within individual sites, a fragmen

A Ang Li

Early Life Exposure to the Great Chinese Famine and Cardiometabolic Outcomes

JAMA Netw Open. 2025 Nov 3;8(11):e2545444. doi: 10.1001/jamanetworkopen.2025.45444.ABSTRACTIMPORTANCE: Epidemiologic studies suggest that people who were exposed to famine during early life but now live in nutrient-abundant environments have an elevated risk of type 2 diabetes (T2D) and other cardio

A Anne Cao

Extreme Heat, Social Factors, and Mortality Among California Veterans With Cardiometabolic Disease

JAMA Netw Open. 2025 Nov 3;8(11):e2545524. doi: 10.1001/jamanetworkopen.2025.45524.ABSTRACTIMPORTANCE: There is limited research investigating associations between extreme heat events (EHEs) and adverse outcomes for veterans and high-risk veteran subpopulations.OBJECTIVES: To investigate the associa

E Evan Michael Shannon

Fibroblast Dynamics Following Partial and Deep Burn Injury in a Reconstructed Human Skin Model

Tissue Eng Regen Med. 2025 Nov 25. doi: 10.1007/s13770-025-00770-5. Online ahead of print.ABSTRACTBACKGROUND: Burn injuries are characterized by extensive and prolonged inflammatory responses that impair wound healing, especially in deep burns. Understanding the post-burn fibroblast dynamics in woun

B Britt van der Leeden

Long-chain acyl-CoA synthetases: biological functions, diseases and therapeutic targets

Mol Biomed. 2025 Nov 25;6(1):117. doi: 10.1186/s43556-025-00366-4.ABSTRACTThe long-chain acyl-CoA synthetase (ACSL) family comprises key enzymes that are integral to the fatty acid metabolic pathway and play crucial roles in governing fatty acid (FA) metabolism and lipid homeostasis. These enzymes a

X Xiaoliang Deng

An evaluation of stage-based survival and renal prognosis in the general super-older population of Japan

Clin Exp Nephrol. 2025 Nov 25. doi: 10.1007/s10157-025-02796-4. Online ahead of print.ABSTRACTBACKGROUND: The risk of mortality and cardiovascular disease (CVD) may be higher among some super-older adults with chronic kidney disease (CKD). We assessed outcomes across CKD stages in an aging Japanese

A Arisa Kobayashi

IL17A Mediates Glycolysis-Dependent Primary Angiogenesis and Exacerbates Ischemic Stroke Injury

Mol Neurobiol. 2025 Nov 25;63(1):169. doi: 10.1007/s12035-025-05387-2.ABSTRACTIschemic stroke poses a significant threat due to its high mortality and disability rates, mainly because of the narrow therapeutic window associated with a complex inflammatory response process and blood brain barrier (BB

Q Qingxue Xu

Research advances in the association between Irisin and obstructive sleep apnea

Sleep Breath. 2025 Nov 25;29(6):365. doi: 10.1007/s11325-025-03550-6.ABSTRACTObstructive sleep apnea (OSA) is a common disorder characterized by recurrent upper airway obstruction leading to intermittent hypoxia and sleep fragmentation. It is closely associated with cognitive impairment, various car

S Shi Luyao

Weight gain under antipsychotic and mood stabilizing treatment: a narrative review about mechanisms and future options

Int J Bipolar Disord. 2025 Nov 25;13(1):33. doi: 10.1186/s40345-025-00397-4.ABSTRACTBACKGROUND: Pharmacological treatment for mental illness can paradoxically compromise physical health, with weight gain and related cardiovascular and metabolic diseases among its most concerning side effects. Unders

H Hilda T Seiter

Eucommia ulmoides Oliver (Duzhong) extract ameliorates cerebral ischemic stroke in mice by remodeling intestinal microbiota and metabolites

Metab Brain Dis. 2025 Nov 25;40(8):325. doi: 10.1007/s11011-025-01750-3.ABSTRACTCerebral stroke is characterized by high rate of disability and mortality. Emerging evidence indicates a relationship between acute ischemic stroke and alterations in the intestinal microbiota. Herein, the mechanism of E

X Xin Qi

Sagittaria Sagittifolia Polysaccharide Ameliorates Diabetic Retinopathy in Mice via Inhibiting TLR4-Mediated Microglial Activation

Mol Neurobiol. 2025 Nov 25;63(1):170. doi: 10.1007/s12035-025-05388-1.ABSTRACTSagittaria sagittifolia polysaccharide (SSP) exhibits anti-inflammatory, antioxidant, lipid-regulating, and hypoglycemic properties, demonstrating therapeutic potential against diabetic retinopathy (DR). This study aimed t

Y Yang Jiang

Cardiovascular adverse events associated with denosumab versus zoledronic acid in patients with breast cancer: a propensity score overlap weighted analysis

Breast Cancer Res Treat. 2025 Nov 25;215(1):16. doi: 10.1007/s10549-025-07852-x.ABSTRACTBACKGROUND: To compare the risks of cardiovascular events, fractures, and all-cause mortality between denosumab and zoledronic acid in patients with breast cancer bone metastases.PATIENTS AND METHODS: We identifi

C Chikako Iwai

Analytical Insights into Ephaptic Coupling and Its Effect on Conduction Velocity

J Math Biol. 2025 Nov 25;91(6):85. doi: 10.1007/s00285-025-02315-9.ABSTRACTCardiovascular disease continues to be the leading cause of death in the United States. A major contributing factor is cardiac arrhythmia, which results from irregular electrical activity in the heart. On a tissue level, card

N Ning Wei

Exercise-derived peptide confers protection against septic cardiomyopathy by enhancing CCAAT/enhancer binding protein β-mediated autophagy

Cell Mol Life Sci. 2025 Nov 25;82(1):421. doi: 10.1007/s00018-025-05949-6.ABSTRACTSeptic cardiomyopathy (SC) is a sepsis-mediated cardiovascular complication characterized by cardiac dysfunction. Emerging evidence indicated that exercise training confers protection against SC; however, the underlyin

X Xiying Huang

Investigating the causal associations between neuroticism, schizophrenia, and cardiovascular diseases using Mendelian randomization

Eur Arch Psychiatry Clin Neurosci. 2025 Nov 25. doi: 10.1007/s00406-025-02163-0. Online ahead of print.ABSTRACTBACKGROUND: This study employed two-sample Mendelian randomization (MR) to investigate the potential causal associations between neuroticism, schizophrenia, and various cardiovascular disea

L Liyuan Pu

Clinical outcomes of drug-coated balloon vs. second-generation drug-eluting stent for coronary in-stent restenosis

Clin Res Cardiol. 2025 Nov 25. doi: 10.1007/s00392-025-02781-7. Online ahead of print.ABSTRACTBACKGROUND: Current guideline recommendations for the treatment of coronary in-stent restenosis (ISR) are primarily based on evidence from smaller, randomized trials comparing drug-coated balloons (DCBs) an

J J Krefting

Multimodal Cardiovascular Risk Profiling Using Self-Supervised Learning of Polysomnography

Sleep. 2025 Nov 25:zsaf371. doi: 10.1093/sleep/zsaf371. Online ahead of print.ABSTRACTSTUDY OBJECTIVES: Polysomnography (PSG) provides a comprehensive assessment of brain, cardiac, and respiratory activity during sleep. While it is widely used for diagnosing sleep disorders, its potential to assess

Z Zhengxiao He

The Economics of Cardiac Rehabilitation in North, Central, and South America: A Narrative Review

Can J Cardiol. 2025 Nov 6:S0828-282X(25)01269-3. doi: 10.1016/j.cjca.2025.10.013. Online ahead of print.ABSTRACTCardiac rehabilitation (CR) is an effective strategy for the secondary prevention of cardiovascular disease in individuals living with ischemic heart disease or heart failure, and among pa

S Sérgio R R Decker

Cardio-Obstetric Care in a Patient With Tricuspid Atresia and Fenestrated Fontan

JACC Case Rep. 2025 Nov 24:106041. doi: 10.1016/j.jaccas.2025.106041. Online ahead of print.ABSTRACTBACKGROUND: Pregnancy in patients with congenital heart disease, particularly those with Fontan physiology, presents significant risks for both the mother and fetus.CASE SUMMARY: We present a 26-year-

F Faysal Massad

Detection of Titin-Associated Electrocardiography Features in Dilated Cardiomyopathy Using Conventional and Deep Neural Network Analysis

JACC Clin Electrophysiol. 2025 Nov 14:S2405-500X(25)00826-6. doi: 10.1016/j.jacep.2025.10.006. Online ahead of print.ABSTRACTBACKGROUND: Titin truncating variants (TTNtvs) are the leading genetic cause of dilated cardiomyopathy (DCM). Although recommended, routine genetic testing is frequently not p

A Astrid B M Heymans

Predicting 30-Days Hospital Readmission for Patients with Heart Failure Using Electronic Health Record Embeddings: Comparative Evaluation

JMIR Med Inform. 2025 Nov 25;13:e73020. doi: 10.2196/73020.ABSTRACTBACKGROUND: Heart failure (HF) is a public health concern with a wider impact on quality of life and cost of care. One of the major challenges in HF is the higher rate of unplanned readmissions and suboptimal performance of models to

P Prabin Shakya

Unraveling the Formation Mechanisms of Trimethylamine N-Oxide and Its Inhibition by Food Ingredients: Toward Cardioprotective Food Development

J Agric Food Chem. 2025 Nov 25. doi: 10.1021/acs.jafc.5c11916. Online ahead of print.ABSTRACTTrimethylamine N-oxide (TMAO), a gut-derived metabolite, has attracted considerable attention in recent years due to its strong association with cardiovascular disease risk. Current studies indicate that foo

W Weiwei He

Endovascular Thrombectomy versus Standard Medical Management in Treatment of Acute Medium Vessel Occlusion Strokes: A Multicenter Registry

Radiology. 2025 Nov;317(2):e251040. doi: 10.1148/radiol.251040.ABSTRACTBackground Randomized trials have shown that endovascular thrombectomy (EVT) benefits patients with large vessel occlusion; however, its role in medium vessel occlusion remains unclear. Purpose To compare the efficacy and safety

X XiaoZhong Jing