J Pharm Pharmacol. 2026 Aug 3;78(8):rgag088. doi: 10.1093/jpp/rgag088.ABSTRACTOBJECTIVES: Chronic inflammation, governed by epigenetic networks, underlies a broad spectrum of diseases. In this context, the long non-coding RNA maternally expressed gene 3 (MEG3) has emerged as a pivotal molecular node
Am Fam Physician. 2026 Jul;114(1):37-44.ABSTRACTClimate change continues to accelerate, driving more frequent and severe weather events, particularly extreme heat. These environmental changes have broad adverse health effects, including increased all-cause mortality, cardiovascular and respiratory d
Proc Natl Acad Sci U S A. 2026 Aug 25;123(34):e2503559123. doi: 10.1073/pnas.2503559123. Epub 2026 Aug 17.ABSTRACTMitral valve (MV) disease, particularly MV prolapse (MVP) and mitral regurgitation (MR), affects 2 to 5% of the population and poses a substantial arrhythmogenic risk, with 43% of MVP pa
J Int Med Res. 2026 Aug;54(8):3000605261476146. doi: 10.1177/03000605261476146. Epub 2026 Aug 17.ABSTRACTGlucose-6-phosphatase catalytic subunit 3 deficiency, also known as Dursun syndrome, is a rare autosomal recessive disorder characterized by severe congenital neutropenia and variable multisystem
PLoS One. 2026 Aug 17;21(8):e0354822. doi: 10.1371/journal.pone.0354822. eCollection 2026.ABSTRACTBACKGROUND: With a large proportion of adults in Canada vaccinated against SARS-CoV-2, it is important to identify who remain at risk for severe COVID-19 outcomes after primary vaccination and additiona
PLoS One. 2026 Aug 17;21(8):e0356055. doi: 10.1371/journal.pone.0356055. eCollection 2026.ABSTRACTBACKGROUND: Spatial neglect is a common attentional condition post-stroke linked to poor rehabilitation outcomes. Prism adaptation, though a promising intervention, is not yet widely used clinically due
PLoS One. 2026 Aug 17;21(8):e0356533. doi: 10.1371/journal.pone.0356533. eCollection 2026.ABSTRACTAcute myocardial infarction (AMI) remains one of the leading causes of sudden death with significant implications in both clinical and forensic practice. In forensic settings, AMI diagnosis traditionall
PLoS One. 2026 Aug 17;21(8):e0355952. doi: 10.1371/journal.pone.0355952. eCollection 2026.ABSTRACTBACKGROUND: Persistent autonomic dysfunction disrupts homeostasis and promotes pathological processes underlying several major chronic conditions including cancer and cardiovascular disease. Little is k
PLoS One. 2026 Aug 17;21(8):e0356426. doi: 10.1371/journal.pone.0356426. eCollection 2026.ABSTRACTCardiovascular disease(CVD) remains a leading cause of mortality worldwide. Among CVDs, coronary heart disease (CHD) is the most prevalent and represents the primary contributor to chronic disease-relat
Blood Purif. 2026 Aug 17:1. doi: 10.1159/bpu/abpag006. Online ahead of print.ABSTRACTINTRODUCTION: Ultrafiltration during hemodialysis can precipitate intradialytic hypotension (IDH), particularly in hospitalized patients with limited cardiovascular reserves. Central venous oxygen saturation (ScvO2)
Elife. 2026 Aug 17;14:RP107730. doi: 10.7554/eLife.107730.ABSTRACTThis study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state and the energy-conserving, ordered
Shock. 2026 Aug 17. doi: 10.1097/SHK.0000000000002926. Online ahead of print.ABSTRACTOver the past five decades, advances in acute burn care have markedly improved early survival following severe thermal injury. However, long-term epidemiologic studies demonstrate that burn survivors remain at incre
Clin Chem. 2026 Aug 17:hvag076. doi: 10.1093/clinchem/hvag076. Online ahead of print.ABSTRACTBACKGROUND: Adrenal-related biomarkers are central in evaluating endocrine causes of secondary hypertension, but their interpretation is influenced by biological variation (BV). In this study, we aimed to es
J Biochem Mol Toxicol. 2026 Sep;40(9):e71081. doi: 10.1002/jbt.71081.ABSTRACTAcute myocardial infarction (AMI) is closely associated with excessive oxidative stress, inflammation, and activation of the renin-angiotensin system (RAS). The active form of vitamin D [1,25(OH)2D3] and the Nrf2 activator
Naunyn Schmiedebergs Arch Pharmacol. 2026 Aug 17. doi: 10.1007/s00210-026-05818-4. Online ahead of print.ABSTRACTRedox imbalance refers to abnormal production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which causes cellular dysfunction and damage, playing a critical role i
Photochem Photobiol Sci. 2026 Aug 17. doi: 10.1007/s43630-026-00970-5. Online ahead of print.ABSTRACTBACKGROUND: Hypertension is the leading global risk factor for cardiovascular disease. Ultraviolet (UV) radiation exposure has been proposed as a potential modifiable environmental factor influencing
Mol Cell Biochem. 2026 Aug 17. doi: 10.1007/s11010-026-05690-z. Online ahead of print.ABSTRACTEndothelial dysfunction, involving diminished nitric oxide (NO) bioavailability and vascular inflammation, plays a pivotal role in cardiovascular disease progression. Anemoside B4 (AB4), a major bioactive c
Cardiovasc Toxicol. 2026 Aug 17;26(9):96. doi: 10.1007/s12012-026-10172-1.ABSTRACTHeart failure (HF) affects over 64 million people worldwide, with five-year mortality rates rivaling solid-organ malignancies. Despite advances in neurohormonal therapy, many patients continue to progress, suggesting a
Mol Neurobiol. 2026 Aug 17;63(1):838. doi: 10.1007/s12035-026-06104-3.ABSTRACTM itochondria act as the energetic hub of eukaryotic cells, orchestrating cellular energy metabolism via oxidative phosphorylation and the tricarboxylic acid (TCA) cycle, thereby subjecting them to continuous environmental
Mol Biol Rep. 2026 Aug 17;53(1):1420. doi: 10.1007/s11033-026-12612-1.ABSTRACTBACKGROUND: Cardiovascular disease (CVD), the leading global cause of death, Acute coronary disease (ACS) is the highest mortality among CVD. Which is driven by thrombo-inflammatory processes involving oxidative stress, en
Acta Diabetol. 2026 Aug 17. doi: 10.1007/s00592-026-02762-w. Online ahead of print.ABSTRACTAIMS: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) increase haematocrit and may cause erythrocytosis, creating uncertainty in type 2 diabetes management. Most available data derive from administrative re
Herzschrittmacherther Elektrophysiol. 2026 Aug 17. doi: 10.1007/s00399-026-01170-5. Online ahead of print.ABSTRACTBACKGROUND: Psychosocial risk factors are well established in the development of cardiovascular disease. However, their role in the onset and progression of atrial fibrillation (AF) has
Cancer Chemother Pharmacol. 2026 Aug 17;96(1):93. doi: 10.1007/s00280-026-04942-5.ABSTRACTSelpercatinib is a selective RET inhibitor with established efficacy in RET-altered malignancies; however, data regarding its long-term safety and pharmacokinetic behavior remain limited. We report a case of fa
Basic Res Cardiol. 2026 Aug 17. doi: 10.1007/s00395-026-01206-4. Online ahead of print.ABSTRACTMalonate, an inhibitor of mitochondrial succinate dehydrogenase (SDH), protects against ischemia-reperfusion injury (IRI) when given at early reperfusion, making it a promising therapeutic agent for acute
