Targeted Delivery of Nucleic Acid Therapeutics: Emerging Carriers and Applications in Common Metabolic and Inflammatory Diseases

Int J Nanomedicine. 2026 Jan 15;21:566642. doi: 10.2147/IJN.S566642. eCollection 2026.ABSTRACTRecent advances in genomics and molecular biology have accelerated the development of nucleic acid-based therapeutics. To optimize their clinical efficacy, various delivery systems-including lipid nanoparti

X Xiyuan Lin

The impact of chronic comorbidities on cancer immunoediting: challenges and opportunities for immunotherapies

Front Immunol. 2026 Mar 6;17:1773872. doi: 10.3389/fimmu.2026.1773872. eCollection 2026.ABSTRACTImmune surveillance is a central function of the immune system that prevents tumor initiation and progression. This process depends on the coordinated activity of innate and adaptive immune responses to r

K Kassandra Ofelia Rodríguez-Aguillón

Interactions between neutrophil extracellular traps and macrophages: the key to inflammatory diseases

Front Immunol. 2026 Mar 6;17:1731687. doi: 10.3389/fimmu.2026.1731687. eCollection 2026.ABSTRACTInteractions between neutrophil extracellular traps (NETs) and macrophages play a critical role in the initiation and progression of inflammatory diseases. NETs regulate macrophage polarization and functi

X Xiaoyu Shan

Taking its TOLL: the role of toll-like receptor 4 in human health and disease, and its potential as a therapeutic target

Front Immunol. 2026 Mar 5;17:1761361. doi: 10.3389/fimmu.2026.1761361. eCollection 2026.ABSTRACTToll-like receptor 4 (TLR4) is a pattern recognition receptor that binds to pathogen associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs). Binding of exogenous or endogen

P Phoebe Crammond

Risks of Myocardial Infarction and Mortality in Patients with Incident Rheumatoid Arthritis Compared with a Matched General Population: A Danish Nationwide Cohort Study

Clin Epidemiol. 2026 Jan 24;18:568967. doi: 10.2147/CLEP.S568967. eCollection 2026.ABSTRACTBACKGROUND AND AIMS: Rheumatoid arthritis (RA) is increasingly being recognized as cardiovascular risk factor. We examined temporal trends in the risks of myocardial infarction (MI) and all-cause mortality in

B Brian Bridal Løgstrup

Brown Tumor in a Patient With End-Stage Renal Disease: A Case Report of Secondary Hyperparathyroidism Complications

Cureus. 2026 Feb 17;18(2):e103787. doi: 10.7759/cureus.103787. eCollection 2026 Feb.ABSTRACTThe development of a brown tumor is a rare complication of secondary hyperparathyroidism, particularly in patients with chronic kidney disease. Despite advances in the treatment and management of secondary hy

A Ahdadi Ahmed

RNA-Based Therapies for Hypercholesterolemia and Coronary Artery Disease

Cureus. 2026 Feb 18;18(2):e103877. doi: 10.7759/cureus.103877. eCollection 2026 Feb.ABSTRACTRNA-based therapies have emerged as a transformative approach in the management of hypercholesterolemia and coronary artery disease by directly targeting molecular pathways involved in lipid regulation. These

M Maynor Jose Lopez Mendoza

Integrated Management Strategies for Diabetes Mellitus and Hypertension: A Systematic Review

Cureus. 2026 Feb 19;18(2):e103893. doi: 10.7759/cureus.103893. eCollection 2026 Feb.ABSTRACTDiabetes mellitus (DM) and hypertension frequently coexist and together substantially increase the risk of cardiovascular morbidity, mortality, and healthcare burden worldwide. Despite growing recognition of

A Amit Nampalliwar

MINOCA (Myocardial Infarction With Non-obstructive Coronary Arteries) Due to Diffuse Coronary Microvascular Dysfunction in a Patient With Systemic Autoimmune Disease and Chronic Kidney Disease

Cureus. 2026 Feb 18;18(2):e103816. doi: 10.7759/cureus.103816. eCollection 2026 Feb.ABSTRACTMyocardial infarction with non-obstructive coronary arteries (MINOCA) represents a heterogeneous entity requiring systematic exclusion of alternative diagnoses and identification of the underlying mechanism.

T Teenu Kamboj

Age at Menarche and Its Association with Cardiovascular Disease in Women with Childhood-Onset Type 1 Diabetes (T1D)

Diabetes Metab Syndr Obes. 2026 Jan 20;19:579879. doi: 10.2147/DMSO.S579879. eCollection 2026.ABSTRACTOBJECTIVE: Early and delayed menarche are associated with increased cardiovascular disease (CVD) risk in the general population, but data are limited in type 1 diabetes (T1D). We thus examined the r

J Jinghui Ju

Functional analysis from ex-vivo characterization of LDLR exon 13-15 duplication associated to familial hypercholesterolemia

Front Endocrinol (Lausanne). 2026 Mar 6;17:1733372. doi: 10.3389/fendo.2026.1733372. eCollection 2026.ABSTRACTBACKGROUND: Familial hypercholesterolemia (FH) is an inherited semidominant disorder characterized by high plasma cholesterol levels and increased risk of premature cardiovascular disease. M

C Catalina Martínez

The impact of maternal gestational diabetes mellitus on cardiac structural and functional parameters in infants

Front Endocrinol (Lausanne). 2026 Mar 5;17:1701975. doi: 10.3389/fendo.2026.1701975. eCollection 2026.ABSTRACTOBJECTIVE: This study aimed to retrospectively analyze changes in cardiac structural and functional parameters in infants born to mothers with nonpharmacologically managed gestational diabet

Y Yuhong Deng

Correction: Cumulative inflammatory burden of metal mixtures is associated with central obesity, cardiovascular disease, and mortality: findings from NHANES

Front Cell Dev Biol. 2026 Mar 5;14:1817293. doi: 10.3389/fcell.2026.1817293. eCollection 2026.ABSTRACT[This corrects the article DOI: 10.3389/fcell.2026.1717247.].PMID:41869019 | PMC:PMC13000348 | DOI:10.3389/fcell.2026.1817293

F Frontiers Production Office

Bridging innate immunity and iron-dependent death: the interplay between cyclic GMP-AMP synthase-stimulator of interferon genes nexus and ferroptosis in cancer and inflammation

Front Cell Dev Biol. 2026 Mar 6;14:1766502. doi: 10.3389/fcell.2026.1766502. eCollection 2026.ABSTRACTThe cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway and ferroptosis have emerged as fundamental biological mechanisms that converge in regulating cellular homeostasis a

X Xin-Xin Chen

Surgical outcomes and quality of life in octogenarians with early-stage non-small cell lung cancer: a prospective cohort study

Lancet Reg Health Am. 2026 Mar 13;56:101428. doi: 10.1016/j.lana.2026.101428. eCollection 2026 Apr.ABSTRACTBACKGROUND: As life expectancy increases, more adults aged ≥80 years are diagnosed with early-stage lung cancer. Often these patients are excluded from screening programs and clinical trials du

L Louis Gros

The Association between Triglycerides to High-density Lipoprotein Cholesterol (TG/HDL-C) Ratio and 10-year Prospective Risk of Type 2 Diabetes Mellitus: Yazd Healthy Heart Project

Adv Biomed Res. 2026 Feb 27;15:16. doi: 10.4103/abr.abr_221_25. eCollection 2026.ABSTRACTBACKGROUND: Although the link between dyslipidemia and type 2 diabetes mellitus (T2DM) is well-established, the predictive value of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio remai

M Mohammad Poorebrahimi

Moringa Oleifera Enhances the Cell Proliferation and Neural Differentiation of B65 and PC12 Cells

Adv Biomed Res. 2026 Feb 27;15:13. doi: 10.4103/abr.abr_523_24. eCollection 2026.ABSTRACTBACKGROUND: Neurodegenerative diseases, marked by progressive symptoms, currently lack definitive, side-effect-free treatments. Research continues for effective therapies. Moringa oleifera extract (MOE), rich in

S Samira Shariati Najafabadi

Network meta-analysis of traditional Chinese exercises for cardiovascular health in middle-aged and older adults hypertensive patients

Front Sports Act Living. 2026 Feb 24;8:1736747. doi: 10.3389/fspor.2026.1736747. eCollection 2026.ABSTRACTINTRODUCTION: Hypertension is a major public health concern, prevalent among aging populations. We aimed to compare the cardiovascular metabolic effects of four traditional Chinese exercises (Ta

S Shaolin Zhou

Relationship between physical activity and cardiovascular disease in adults

Am J Transl Res. 2026 Feb 15;18(2):1145-1156. doi: 10.62347/UTCE7195. eCollection 2026.ABSTRACTOBJECTIVE: Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide, with physical inactivity identified as a critical modifiable risk factor - the association between phys

B Binbin Hu

Determinants of the healthy gut microbiome: core features, modifying factors and normal functions

Ann Gastroenterol. 2026 Mar-Apr;39(2):191-201. doi: 10.20524/aog.2026.1034. Epub 2026 Jan 26.ABSTRACTThe human gut microbiome represents a complex and dynamic ecosystem that is central to maintaining health and preventing disease. Defining a "normal" gut microbiome remains challenging, given the sig

I Ilektra Kyrochristou

Plant-Based Dietary Patterns and Neuroimaging Biomarkers of Brain Health: A Scoping Review of Observational and Interventional Evidence

Am J Lifestyle Med. 2026 Mar 19:15598276261434176. doi: 10.1177/15598276261434176. Online ahead of print.ABSTRACTHealthy dietary interventions are well established in cardiovascular disease prevention, but their effects on the brain remain underexplored. This scoping review aims to investigate how a

L Lydia Viviana Falsitta

Treating Women With Calcified Coronary Arteries Using Intravascular Lithotripsy: Primary Results of the EMPOWER CAD Study

J Soc Cardiovasc Angiogr Interv. 2026 Feb 10;5(3):104191. doi: 10.1016/j.jscai.2025.104191. eCollection 2026 Mar.ABSTRACTBACKGROUND: Percutaneous coronary intervention of severely calcified coronary lesions is associated with a higher risk of adverse events in women compared with men.METHODS: EMPOWE

M Margaret McEntegart

Angiography-Derived Physiology for Coronary Artery Disease Assessment: Expert Opinion From a SCAI Roundtable

J Soc Cardiovasc Angiogr Interv. 2026 Feb 3;5(3):104156. doi: 10.1016/j.jscai.2025.104156. eCollection 2026 Mar.ABSTRACTAngiography-derived physiology (ADP) is an emerging technique that offers streamlined, wire-free assessment of epicardial coronary physiology. This is accomplished by applying comp

E Evan Shlofmitz

Major Adverse Limb Events and Death After Successful Endovascular Revascularization: BEST-CLI Trial

J Soc Cardiovasc Angiogr Interv. 2026 Feb 24;5(3):104192. doi: 10.1016/j.jscai.2025.104192. eCollection 2026 Mar.ABSTRACTBACKGROUND: Chronic limb-threatening ischemia (CLTI) has a high risk of limb amputation without revascularization. In the Best Surgical Therapy in CLTI (BEST-CLI) trial, endovascu

S Scott Kinlay