Non-infectious environmental risk factors of multiple sclerosis: Mechanisms and intervention windows for prevention

Rev Neurol (Paris). 2026 Apr 14:S0035-3787(26)00504-7. doi: 10.1016/j.neurol.2026.03.010. Online ahead of print.ABSTRACTThe trajectory of multiple sclerosis (MS) is shaped by complex interactions between genetic susceptibility and environmental factors. This review examines modifiable non-infectious

M M Rival

Evaluation of a posteriori dietary pattern methods in cardiovascular disease: a systematic review

Nutrition. 2026 Mar 12;148:113202. doi: 10.1016/j.nut.2026.113202. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular disease (CVD) is a leading global cause of mortality, strongly influenced by diet. Research in this field has evolved from the analysis of nutrients to the evaluation of dietar

M Mónica Lavinia Popescu

The self-efficacy perception in cardiovascular patients: A cohort study on self-care management

J Psychosom Res. 2026 Apr 13;207:112675. doi: 10.1016/j.jpsychores.2026.112675. Online ahead of print.ABSTRACTOBJECTIVE: The international cardiovascular guidelines emphasise self-care as a key factor for better health management in patients. Self-care incorporated into patient engagement is conside

D Dina Di Giacomo

Sex Hormone Influences on Venous Thrombotic and Cardiovascular Risk

N Engl J Med. 2026 Apr 16;394(15):1514-1528. doi: 10.1056/NEJMra2202438.ABSTRACTThrombosis is a recognized complication of sex hormone therapy, which includes hormone replacement for deficiencies, contraceptive therapy, treatment of heavy menstrual bleeding, gender-affirming hormone therapy, suppres

L Leslie Skeith

Randomized Trial of Adjunctive Prednisolone for Kawasaki Disease

N Engl J Med. 2026 Apr 16;394(15):1480-1490. doi: 10.1056/NEJMoa2511478.ABSTRACTBACKGROUND: The effect of adjunctive glucocorticoids in the primary treatment of Kawasaki disease in unselected patients remains unknown.METHODS: In this multicenter, open-label, randomized, controlled trial in China, we

S Siyuan Lin

Asundexian for Secondary Stroke Prevention

N Engl J Med. 2026 Apr 16;394(15):1467-1479. doi: 10.1056/NEJMoa2513880.ABSTRACTBACKGROUND: Patients with noncardioembolic ischemic stroke or transient ischemic attack (TIA) are at risk for recurrent stroke. Low factor XI levels are associated with a reduced risk of ischemic stroke. Asundexian inhib

M Mukul Sharma

Antidiabetic Drug Associations With Heart Failure Outcomes: Real-World Evidence Study Using Electronic Health Records

JMIR Diabetes. 2026 Apr 15;11:e85083. doi: 10.2196/85083.ABSTRACTBACKGROUND: Patients with type 2 diabetes mellitus (T2D) have a higher risk of cardiovascular disease, including heart failure (HF), leading to health care burden including hospitalization and mortality. Among multiple T2D therapies, t

E Elzbieta Jodlowska-Siewert

Automated Identification of Cardiopulmonary Disease Cases for Preoperative Risk Stratification Using Machine Learning: A Retrospective Analysis

A A Pract. 2026 Apr 15;20(4):e02183. doi: 10.1213/XAA.0000000000002183. eCollection 2026 Apr 1.ABSTRACTBACKGROUND: Preoperative chart review is time-consuming and prone to errors, particularly for cardiopulmonary conditions that impact anesthetic planning. We developed a guideline-aligned "clinical

I Ishan Aggarwal

Genetic Association of the Renin-Angiotensin-Aldosterone System with hypertension among the Malays and their adaptation to climate change

PLoS One. 2026 Apr 15;21(4):e0346614. doi: 10.1371/journal.pone.0346614. eCollection 2026.ABSTRACTHypertension (HT) is a 'by-product' to the forces of natural selection against environmental drift and salt availability, therefore contributed to differential HT susceptibility. This study provides fur

N Nur Hasnah Maamor

Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology

Sci Transl Med. 2026 Apr 15;18(845):eadz7727. doi: 10.1126/scitranslmed.adz7727. Epub 2026 Apr 15.ABSTRACTA well-recognized attribute of several common and standard cancer therapeutics is the development of cardiotoxicity. Although many anticancer agents appear to target a relatively select and dist

M Maria Areli Lorenzana-Carrillo

Validating the 2-minute walk test MCID for subacute stroke patients: A Pakistani multicenter cohort analysis

PLoS One. 2026 Apr 15;21(4):e0347056. doi: 10.1371/journal.pone.0347056. eCollection 2026.ABSTRACTBACKGROUND: The 2-Minute Walk Test (2MWT) is a simple and reliable test used by clinicians to evaluate mobility gains in stroke populations.OBJECTIVE: To determine the minimally clinically important dif

M Muslim Khan

Bayesian hierarchical models for multivariate mixed responses with repeated measures: A case study in arterial occlusive disease

PLoS One. 2026 Apr 15;21(4):e0346331. doi: 10.1371/journal.pone.0346331. eCollection 2026.ABSTRACTModeling repeated measures of arterial occlusive diseases, such as peripheral artery disease (PAD), using data with mixed-type outcomes poses unique challenges due to complex dependency structures and d

E Endris Assen Ebrahim

PPP1R3G-RIPK1-ZBP1 axis activates early-stage apoptosis and late-stage necroptosis to promote doxorubicin-induced cardiotoxicity

Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2603301123. doi: 10.1073/pnas.2603301123. Epub 2026 Apr 15.ABSTRACTCardiotoxicity is a dose-limiting complication of doxorubicin (DOX) chemotherapy, yet the molecular mechanisms governing the transition from acute stress to terminal heart failure remain

X Xueling Ma

Heart failure and preserved ejection fraction: pathophysiology, clinical assessment, and management of exercise intolerance

Eur Heart J. 2026 Apr 15:ehag175. doi: 10.1093/eurheartj/ehag175. Online ahead of print.ABSTRACTExercise intolerance is a clinical hallmark of heart failure with preserved ejection fraction (HFpEF) that confers high morbidity and predicts mortality. The mechanisms underlying exercise intolerance in

I Isabela Landsteiner

Impact of diagonal branch angle on cardiac outcomes after sequential coronary bypass surgery

Interdiscip Cardiovasc Thorac Surg. 2026 Apr 15:ivag101. doi: 10.1093/icvts/ivag101. Online ahead of print.ABSTRACTOBJECTIVES: To evaluate whether the diagonal branch anastomotic angle (D-angle) influences outcomes following coronary artery bypass grafting (CABG).METHODS: This study retrospectively

A Akinobu Ohtani

Interpreting circulating microbiome-related metabolites in coronary heart disease

PLoS Med. 2026 Apr 15;23(4):e1005056. doi: 10.1371/journal.pmed.1005056. eCollection 2026 Apr.ABSTRACTCirculating microbiome-related metabolites have emerged as promising biomarkers for coronary heart disease. A recent multi-stage study in PLOS Medicine strengthens signal prioritization but highligh

Z Zhonghan Sun

Ultra-processed food consumption and the risk of overweight and obesity in adolescents: A systematic review and meta-analysis

PLoS One. 2026 Apr 15;21(4):e0344873. doi: 10.1371/journal.pone.0344873. eCollection 2026.ABSTRACTINTRODUCTION: Overweight and obesity during early life increase the risk of premature morbidity and mortality. Adolescent obesity raises the likelihood of developing cardiovascular risk factors, includi

M Mekuriaw Nibret Aweke

Mineralocorticoid Receptor Antagonists in Dialysis

Am J Nephrol. 2026 Apr 15:1-27. doi: 10.1159/000551881. Online ahead of print.ABSTRACTBACKGROUND: Aldosterone regulates genes controlling fluid and electrolyte balance through mineralocorticoid receptor (MR) activation. Sustained MR activation promotes inflammation, fibrosis, sodium retention, and m

E Elias John Elenjickal

More Than Skin Deep: A Case of Stroke Secondary to Hidradenitis Suppurativa

Mil Med. 2026 Apr 15:usag163. doi: 10.1093/milmed/usag163. Online ahead of print.ABSTRACTIschemic strokes in young adults are often classified as cryptogenic when standard evaluation fails to identify an underlying cause. Growing evidence connects systemic inflammatory diseases, such as rheumatoid a

D Danielle Lacasse

The impact of clinical presentation on one-year major adverse cardiac events in patients with angiographically defined moderate to severe calcified coronary artery disease

J Invasive Cardiol. 2026 Apr 13. doi: 10.25270/jic/26.00022. Online ahead of print.ABSTRACTOBJECTIVES: The authors aimed to investigate the impact of clinical presentation on 1-year major adverse cardiac events (MACE) in patients with angiographically defined moderate or severe calcified coronary ar

A Argisjt Mkrtchjan

Prognostic value of atherogenicity indices in schizophrenia patients with metabolic syndrome

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(3):155-160. doi: 10.17116/jnevro2026126031155.ABSTRACTOBJECTIVE: To study the prognostic value of atherogenicity indices in schizophrenia patients taking antipsychotics.MATERIAL AND METHODS: The study included 460 patients with schizophrenia. Metabolic

S S A Galkin

Drug-drug interactions with Mexidol in patients with ischemic stroke: Analysis of data from randomized clinical trials

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(3):141-154. doi: 10.17116/jnevro2026126031141.ABSTRACTOBJECTIVE: Identification of drug-drug interaction of Mexidol when used in patients with ischemic stroke.MATERIAL AND METHODS: The data from randomized controlled clinical trials (RCTs) of the effica

E E V Shikh

The effectiveness of citicoline in the treatment of cognitive disorders

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(3):136-140. doi: 10.17116/jnevro2026126031136.ABSTRACTRandomized controlled trials, systematic reviews, and meta-analyses have shown that citicoline is highly effective in the treatment of vascular cognitive impairments (CI) of various origins (post-str

O O A Shavlovskaya

Experience of using Relatox in the complex rehabilitation of patients with lower limb spasticity after focal brain damage of various etiologies

Zh Nevrol Psikhiatr Im S S Korsakova. 2026;126(3):126-135. doi: 10.17116/jnevro2026126031126.ABSTRACTOBJECTIVE: Evaluating the safety and efficacy of Relatox, a Russian botulinum neuroprotein type A preparation, in the comprehensive rehabilitation of patients with focal and multipattern lower limb s

S S E Khatkova