EFFICACY OF PERINDOPRIL IN PATIENTS WITH HEART FAILURE AND REDUCED EJECTION FRACTION

Georgian Med News. 2026 Jun;(375):238-247.ABSTRACTBACKGROUND/INTRODUCTION: Heart failure with reduced ejection fraction (HFrEF) represents a major global health burden, accounting for approximately half of all heart failure cases and characterized by high mortality, frequent hospitalizations, and pr

N N Nazghaidze

ASSESSING THE EFFECTIVENESS OF LIFESTYLE CLINIC INTERVENTIONS ON CARDIOMETABOLIC RISK FACTORS: A RETROSPECTIVE STUDY

Georgian Med News. 2026 Jun;(375):230-237.ABSTRACTBACKGROUND: Cardiometabolic disorders, including diabetes mellitus, hypertension, dyslipidemia, and obesity, represent a significant global health burden. While lifestyle interventions are recommended, evidence from real-world clinical settings in Sa

Z Z Althumali

PREVENTION OF LOCAL POSTOPERATIVE COMPLICATIONS IN THE SURGICAL TREATMENT OF CHRONIC VENOUS INSUFFICIENCY OF THE LOWER EXTREMITIES (CEAP C3-C5)

Georgian Med News. 2026 Jun;(375):212-221.ABSTRACTINTRODUCTION: Chronic venous insufficiency of the lower extremities remains one of the most significant problems of modern vascular surgery and angiology because of its high prevalence, progressive course, and association with edema, trophic skin cha

Y Y Salmenbayev

ASSESSMENT OF SUBCLINICAL RENAL INSULT IN SHORT- AND LONG-TERM UNCONTROLLED HYPERTENSION USING MOLECULAR BIOMARKERS OF NGAL AND KIM-1

Georgian Med News. 2026 Jun;(375):147-152.ABSTRACTBACKGROUND: Uncontrolled Hypertension (UHTN) is a major cause of rapidly deteriorating kidney function. Typical clinical indicators often lack the sensitivity necessary for early detection of tubular changes preceding irreversible damage to the nephr

R R Alathary

CEREBROVASCULAR EVENTS AND NEUROCOGNITIVE IMPAIRMENTS WITH ALTERATIONS IN POLYSOMNOGRAPHIC INDICATORS FOLLOWING CARDIAC SURGERY

Georgian Med News. 2026 Jun;(375):6-15.ABSTRACTINTRODUCTION: Cardiac surgery involving cardiopulmonary bypass (CPB) is frequently associated with a spectrum of postoperative neurological complications, ranging from transient neurocognitive decline to permanent cerebrovascular damage. These events ar

E E Tsitlidze

Lactate-Induced K370 Lactylation of STING Inhibits STING-TBK1 Signaling and Dampens Anti-Tumor Immunity

Adv Sci (Weinh). 2026 Aug 15:e77209. doi: 10.1002/advs.77209. Online ahead of print.ABSTRACTThe stimulator of interferon genes (STING) pathway represents a central component of innate anti-tumor immunity; however, the efficacy of STING-targeted therapies is frequently limited by tumor-intrinsic resi

Y Yueyao Wu

Exploring Gray Matter Alterations in Post-Stroke Patients: A Structural Covariance Analysis

Brain Behav. 2026 Aug;16(8):e71667. doi: 10.1002/brb3.71667.ABSTRACTBACKGROUND: While structural covariance analysis is adept at assessing morphometric correlations among broadly distributed brain regions, limited research has focused on alterations in structural covariance networks post-stroke. Thi

J Juan-Juan Lu

Shockwave Therapy or Acupoint Stimulation Combined With Physiotherapy for Spasticity and Motor Function in Post-Stroke Recovery: A Randomized Controlled Trial

Brain Behav. 2026 Aug;16(8):e71652. doi: 10.1002/brb3.71652.ABSTRACTBACKGROUND: Stroke frequently causes spasticity and motor impairment, reducing independence. Non-invasive treatments like radial extracorporeal shockwave therapy (ESWT) and acupoint-based transcutaneous electrical nerve stimulation

K Kazi Md Azman Hossain

Gut Microbiota and Ischemic Stroke: From Pre-Stroke Dysbiosis and Acute-Phase Changes to Therapeutic Applications

Brain Behav. 2026 Aug;16(8):e71547. doi: 10.1002/brb3.71547.ABSTRACTPURPOSE: Ischemic stroke poses a major global health burden, and growing evidence points to the microbiota-gut-brain axis as an important contributor to stroke pathophysiology and recovery. The purpose of this review is to summarize

R Ruihui Weng

Challenges and Adjunctive Use of CT Perfusion (CTP) in Acute Stroke: Pitfalls, False Negatives, and Diagnostic Clues for Stroke Mimics

Curr Neurol Neurosci Rep. 2026 Aug 15;26(1):40. doi: 10.1007/s11910-026-01510-5.ABSTRACTPURPOSE OF REVIEW: Computed tomography perfusion (CTP) has become an important tool for tissue-based assessment in acute ischemic stroke, particularly in patients considered for reperfusion therapy beyond convent

H Hiroyuki Kawano

Integrated analysis of the diabetic foot ulcer microbiome and host transcriptome supports a microenvironment-microbiota-host repair framework

Endocrine. 2026 Aug 15;91(1):279. doi: 10.1007/s12020-026-04754-w.ABSTRACTBACKGROUND: Diabetic foot ulcers (DFUs) arise from interacting clinical, microbial, and host processes, yet public datasets differ substantially in design, scale, and evidentiary strength.METHODS: We curated eight public DFU c

J Jiaqi Lou

Effect of tirzepatide and semaglutide on blood pressure: A systematic review and meta-analysis

Endocrine. 2026 Aug 15;91(1):275. doi: 10.1007/s12020-026-04757-7.ABSTRACTPURPOSE: Tirzepatide and semaglutide are widely used for type 2 diabetes mellitus (T2DM) and obesity. However, the blood pressure-related adverse event profiles associated with tirzepatide and semaglutide remain unclear. This

Q Qing-Xin Chen

Injectable Lipid-Lowering Therapies in Advanced Chronic Kidney Disease: Efficacy, Safety and the Dialysis Paradox

Cardiovasc Drugs Ther. 2026 Aug 15. doi: 10.1007/s10557-026-07934-y. Online ahead of print.ABSTRACTCardiovascular (CV) disease represents the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD), particularly in those with advanced stages and dialysis dependence. Dy

A Aikaterini Damianaki

Association of non-invasive liver-related scores with cardiovascular disease and a four-domain cardiovascular-renal-hepatic-metabolic phenotype in patients with type 2 diabetes mellitus and MASLD

Endocrine. 2026 Aug 15;91(1):276. doi: 10.1007/s12020-026-04751-z.ABSTRACTOBJECTIVE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a systemic disorder associated with cardiovascular, renal, and metabolic comorbidities. We evaluated cardiovascular disease (CVD), four-domain card

K Katerina Stefanaki

Differential association of hypothyroidism with cardiovascular events and cardiovascular mortality: a systematic review and meta-analysis

Endocrine. 2026 Aug 15;91(1):277. doi: 10.1007/s12020-026-04745-x.ABSTRACTPURPOSE: The cardiovascular impact of hypothyroidism remains controversial, particularly regarding the distinction between cardiovascular disease occurrence and cardiovascular prognosis. We performed a systematic review and me

E Elisa Gatta

Comprehensive Analysis of Starvation Response-Related Genes in the Diagnosis of Ischemic Stroke: Based on Machine Learning and Single-Cell RNA Sequencing Data

J Mol Neurosci. 2026 Aug 15;76(3):131. doi: 10.1007/s12031-026-02592-z.ABSTRACTBACKGROUND: The pathogenesis of ischemic stroke (IS) involves a starvation response (SR); however, the mechanistic link between the two remains unclear. Therefore, it is imperative to identify SR-related gene (SRRG) bioma

J Junjie Li

Extracriteria manifestations in Kawasaki disease: coronary threat or diagnostic pitfall?

Eur J Pediatr. 2026 Aug 15;185(9):667. doi: 10.1007/s00431-026-07339-x.ABSTRACTKawasaki disease (KD) may present with manifestations beyond classical diagnostic criteria, but data on extracriteria manifestations as a multisystem phenotype remain limited. We aimed to assess the frequency and clinical

G Gamze Vuran

Patient-specific static and dynamic 3D-printed models for planning endovascular repair of complex aortic disease with physician-modified stent grafts

CVIR Endovasc. 2026 Aug 15;9(1):103. doi: 10.1186/s42155-026-00755-y.ABSTRACTOBJECTIVE: To develop a patient-specific static and dynamic 3D-printing workflow for preoperative planning of endovascular repair in complex aortic disease with physician-modified stent grafts, to assess the respective role

Q Qincheng Gong

Atherogenic and inflammatory biomarkers in NSTEMI: a comparative analysis of predictive value for obstructive coronary disease

Acta Clin Belg. 2026 Aug 15:1-15. doi: 10.1080/17843286.2026.2719660. Online ahead of print.ABSTRACTBACKGROUND: The atherogenic index of plasma (AIP) and inflammatory indices may reflect the burden of atherosclerosis. This study evaluated their predictive value for obstructive coronary artery diseas

V Veysi Can

Mitochondrial Omics in Macrophage Foam Cell Formation and Atherosclerosis

Proteomics. 2026 Aug 15:e70172. doi: 10.1002/pmic.70172. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) is a leading cause of death worldwide, with atherosclerosis serving as the core pathological mechanism driving ischemic heart disease, ischemic stroke, and peripheral

E Enhui Wu

Discordance between symptomatic, echocardiographic and renal trajectories after SGLT2 inhibitor initiation in heart failure: a landmark analysis of the prospective CaRD registry

Acta Clin Belg. 2026 Aug 15:1-13. doi: 10.1080/17843286.2026.2719667. Online ahead of print.ABSTRACTOBJECTIVES: To quantify the concordance and stability of symptomatic, echocardiographic and renal trajectories after sodium-glucose cotransporter 2 inhibitor (SGLT2i) initiation and examine their asso

I Ivana Jurin

Polygonum cuspidatum Exosome-Like Nanovesicles Alleviate Hypoxic Pulmonary Hypertension by Stabilizing PON1 to Inhibit MAPK-Mediated PASMC Phenotypic Switching

FASEB J. 2026 Aug 31;40(16):e72157. doi: 10.1096/fj.202600973R.ABSTRACTHypoxic pulmonary hypertension (HPH) is characterized by excessive proliferation of pulmonary vascular cells, ultimately resulting in right heart failure and death. Although resveratrol, an active component of Polygonum cuspidatu

B Bingchen Chen

Sex Differences in Peripheral Arterial Disease: Presentation, Treatment, and Outcomes

Int J Angiol. 2026 Jun 11;35(3):170-173. doi: 10.1055/a-2886-6566. eCollection 2026 Sep.ABSTRACTTo summarize current evidence on sex-related differences in peripheral arterial disease (PAD) with respect to risk factors, disease distribution, response to endovascular therapy, and surgical outcomes. T

N Nicolas W Shammas

Pediatric extracorporeal membrane oxygenation support at a single center: Outcomes by indication, prognostic factors, and duration

Ann Pediatr Cardiol. 2026 Jul-Aug;19(4):396-404. doi: 10.4103/apc.apc_115_26. Epub 2026 Jul 31.ABSTRACTBACKGROUND: Pediatric extracorporeal membrane oxygenation (pECMO) provides life-saving cardiopulmonary support for children with severe cardiac or respiratory failure. Identifying prognostic factor

L L Lily Rosenthal