Acta Pharmacol Sin. 2025 Dec 8. doi: 10.1038/s41401-025-01690-9. Online ahead of print.ABSTRACTParkinson's disease (PD) involves α-synuclein (αSyn) oligomerization and aggregation, processes facilitated by glycosphingolipids. Defective glycosphingolipid transport and degradation-especially via the l
Mol Neurobiol. 2025 Dec 9;63(1):275. doi: 10.1007/s12035-025-05549-2.ABSTRACTCyclosporine, tacrolimus, pimecrolimus and newer derivatives of cyclosporine such as voclosporin are calcineurin inhibitors (CNIs), have a potent immunosuppressant effect. They act by inhibiting the calcium dependent phosph
Spine Deform. 2025 Dec 8. doi: 10.1007/s43390-025-01228-3. Online ahead of print.ABSTRACTPURPOSE: This systematic review and meta-analysis aim to investigate the prevalence of cardiac abnormalities in patients with idiopathic scoliosis.METHODS: A systematic search on PubMed, Embase, Scopus, and Web
Sci Rep. 2025 Dec 8. doi: 10.1038/s41598-025-31548-3. Online ahead of print.ABSTRACTCarrier-mediated drug delivery is one of the potential approaches employed to increase drug solubility and bioavailability. Atorvastatin (ATR), a HMG CoA reductase inhibitor, is a first-line medication prescribed for
J Hum Hypertens. 2025 Dec 9. doi: 10.1038/s41371-025-01103-8. Online ahead of print.ABSTRACTThe Simplified Cardiovascular Management Program (SimCard), a cluster-randomized controlled trial conducted in Tibet, China, demonstrated significant reduction in systolic blood pressure (SBP) compared to usu
BMC Sports Sci Med Rehabil. 2025 Dec 9. doi: 10.1186/s13102-025-01456-0. Online ahead of print.ABSTRACTBACKGROUND: Coenzyme Q10 (CoQ10), a vital mitochondrial antioxidant, may enhance cardiovascular recovery and delay fatigue in athletes. This double-blind, randomized, placebo-controlled trial inves
BMC Psychol. 2025 Dec 9. doi: 10.1186/s40359-025-03810-w. Online ahead of print.ABSTRACTBACKGROUND: Depression is a big health concern and a leading cause of disability worldwide that is inadequately addressed. Severe somatic illnesses are often associated with psychological distress that can reach
J Transl Med. 2025 Dec 8;23(1):1385. doi: 10.1186/s12967-025-06834-3.ABSTRACTBACKGROUND: Obesity-related cardiac injury is a serious global condition associated with excessive fat intake, which is strongly linked to chronic low-degrade inflammation. Pyroptosis, a pro-inflammatory form of cell death,
Cardiovasc Diabetol. 2025 Dec 8. doi: 10.1186/s12933-025-03022-x. Online ahead of print.ABSTRACTFrailty and cardiometabolic disorders are highly prevalent in the aging population and frequently coexist, amplifying each other's adverse effects. Frailty, defined by decreased physiological reserves and
Sci Rep. 2025 Dec 8. doi: 10.1038/s41598-025-31735-2. Online ahead of print.ABSTRACTChronic kidney disease (CKD) contributes to poor renal and cardiovascular outcomes, necessitating early detection and intervention. The current study investigated the variability in CKD management practices across cl
BMC Psychol. 2025 Dec 9. doi: 10.1186/s40359-025-03814-6. Online ahead of print.ABSTRACTINTRODUCTION: In recent years, Life's Essential 8 (LE8) has been increasingly applied as an indicator to assess cardiovascular health condition. Depression is common in patients with cardiovascular diseases (CVD)
BMC Med. 2025 Dec 9. doi: 10.1186/s12916-025-04552-7. Online ahead of print.ABSTRACTBACKGROUND: Although the 2021 European Society of Cardiology (ESC) guidelines and Systematic COronary Risk Estimation 2 (SCORE2) models provide structured risk assessment, their complexity may hinder routine use. The
BMC Public Health. 2025 Dec 8;25(1):4230. doi: 10.1186/s12889-025-25352-x.ABSTRACTBACKGROUND: The opportunity of long-term exposure to non-optimal temperature and relative humidity (RH) may increase which might contribute to elevations in blood pressure (BP). This study aimed to examine the joint ef
BMC Cardiovasc Disord. 2025 Dec 9. doi: 10.1186/s12872-025-05374-4. Online ahead of print.ABSTRACTBACKGROUND: Coronary heart disease (CHD) remains one of the leading causes of morbidity and mortality worldwide. Percutaneous coronary intervention (PCI) is widely used to restore coronary perfusion and
Sci Rep. 2025 Dec 8;15(1):43334. doi: 10.1038/s41598-025-27330-0.ABSTRACTRemnant cholesterol (RC) serves as an important indicator for assessing atherosclerotic cardiovascular disease, however, correlation with contrast-induced acute kidney injury (CI-AKI) remains unclear. This research investigated
Sci Rep. 2025 Dec 8;15(1):43333. doi: 10.1038/s41598-025-27295-0.ABSTRACTDexmedetomidine (DEX), a selective α2-adrenoceptor agonist, is used in critical care for sedation and sympathetic modulation. However, its association with survival after cardiac arrest remains uncertain.This study investigated
Nat Commun. 2025 Dec 8. doi: 10.1038/s41467-025-67126-4. Online ahead of print.ABSTRACTMobility impairments from aging, injury, or medical conditions limit independence and social participation. Conventional assistive devices lack adaptability in complex environments. Recent wearable technologies in
Signal Transduct Target Ther. 2025 Dec 9;10(1):399. doi: 10.1038/s41392-025-02497-0.ABSTRACTHyperuricemia is considered a modifiable risk factor for the development and progression of chronic kidney disease (CKD). There remains controversy over the effects of urate-lowering therapy (ULT) on kidney o
Nat Commun. 2025 Dec 8;16(1):10854. doi: 10.1038/s41467-025-65903-9.ABSTRACTAge-related macular degeneration (AMD) is a multifactorial retinal disease with a large genetic risk contribution. Reticular pseudodrusen (RPD) is a sub-phenotype of AMD with a high risk of progression to late vision threate
MMW Fortschr Med. 2025 Dec;167(Suppl 6):9-14. doi: 10.1007/s15006-025-5435-0.ABSTRACTBACKGROUND: A common comorbidity in heart failure is iron deficiency, which aggravates the symptoms of heart failure and is associated with increased hospital admissions. Iron deficiency is easily treatable, but is
MMW Fortschr Med. 2025 Dec;167(Suppl 6):3-8. doi: 10.1007/s15006-025-5490-6.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) is frequently underdiagnosed. In particular, the determination of albumin excretion in urine (urine albumin-creatinine ratio, UACR) is rarely performed despite existing indica
NPJ Digit Med. 2025 Dec 8. doi: 10.1038/s41746-025-02220-x. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatohepatitis (MASH) increases liver-related mortality risk more than tenfold, yet reliable predictive biomarkers remain scarce. This study developed the MASHRisk score, a blo
Nat Metab. 2025 Dec 8. doi: 10.1038/s42255-025-01413-8. Online ahead of print.ABSTRACTThe global type 2 diabetes epidemic is a major health crisis. Although the microbiome has roles in the onset of insulin resistance (IR), low-grade inflammation and diabetes, the microbial compounds controlling thes
J Neurol. 2025 Dec 8;273(1):16. doi: 10.1007/s00415-025-13560-9.ABSTRACTBACKGROUND: Glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as key agents in managing type 2 diabetes mellitus (T2DM), with proven benefits in glycemic control, weight loss, and cardiovascular risk reduction. Howe
