The Therapeutic Potential of Purmorphamine Across Disease Models

J Cell Mol Med. 2026 Sep;30(17):e71349. doi: 10.1111/jcmm.71349.ABSTRACTPurmorphamine (PUR) is a trisubstituted purine compound that selectively activates Smoothened receptor, thereby initiating Sonic Hedgehog (Shh) signalling-a pathway critical for embryonic patterning, neuronal specification and t

A Ashis Dhar

Preoperative global longitudinal strain predicts myocardial hypertrophy burden but not the magnitude of reverse remodeling after surgical aortic valve replacement in severe aortic stenosis

J Cardiovasc Imaging. 2026 Sep 4;34(1):30. doi: 10.1186/s44348-026-00089-2.ABSTRACTBACKGROUND: Global longitudinal strain (GLS) is a marker of subclinical myocardial dysfunction and predicts adverse outcomes in severe aortic stenosis. However, its ability to predict the magnitude of left ventricular

J Joy Wulansari Purba

ECG-based detection of occlusion myocardial infarction: a dedicated deep neural network versus multimodal large language models and physicians - a retrospective diagnostic accuracy study

BMC Emerg Med. 2026 Aug 7;26(1):237. doi: 10.1186/s12873-026-01716-3.ABSTRACTBACKGROUND: Accurate electrocardiogram (ECG) interpretation for acute coronary occlusion is a critical, time-sensitive task in emergency care. The field is increasingly shifting from the ST-segment elevation myocardial infa

E Emin Hüseyin Akar