J Drug Target. 2026 Aug 22:1-30. doi: 10.1080/1061186X.2026.2724027. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disorder that involves the formation of amyloid-β (Aβ) aggregates, and the development of targeted therapeutic strategies is needed. In the c
Sci Bull (Beijing). 2026 Aug 8:S2095-9273(26)00908-4. doi: 10.1016/j.scib.2026.08.023. Online ahead of print.ABSTRACTThe reprogramming of myocardial energy metabolism is critical for cardiac repair after ischemia/reperfusion (I/R) injury, yet the upstream translational control mechanisms remain elus
Eur J Intern Med. 2026 Aug 22:107135. doi: 10.1016/j.ejim.2026.107135. Online ahead of print.ABSTRACTBACKGROUND: Bariatric surgery is associated with significant improvements in cardiometabolic health. The apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio has been demonstrated to be a strong p
J Cardiovasc Comput Tomogr. 2026 Aug 13:S1934-5925(26)00461-2. doi: 10.1016/j.jcct.2026.07.013. Online ahead of print.ABSTRACTBACKGROUND: Non-calcified coronary atherosclerosis may be present despite a coronary artery calcium (CAC) score of zero, but its metabolic determinants are not well defined.
J Pharmacol Sci. 2026 Oct;162(2):162-178. doi: 10.1016/j.jphs.2026.07.004. Epub 2026 Jul 23.ABSTRACTFriedelin (FD), a natural pentacyclic triterpene, exerts neuroprotective effects, but its role in cerebral ischemic stroke remains unknown. In this study, FD attenuated middle cerebral artery occlusio
J Pharmacol Sci. 2026 Oct;162(2):130-142. doi: 10.1016/j.jphs.2026.07.006. Epub 2026 Aug 3.ABSTRACTPURPOSE: To investigate the role of Frizzled-7 (FZD7) in diabetic retinopathy (DR) and elucidate the molecular mechanism by which FZD7 regulates ferroptosis during disease progression.METHODS: Core DR-
J Pharmacol Sci. 2026 Oct;162(2):117-129. doi: 10.1016/j.jphs.2026.07.005. Epub 2026 Jul 30.ABSTRACTIschemic stroke (IS) triggers neuroinflammation that drives neuronal dysfunction and tissue injury. Resident central nervous system macrophages critically contribute to IS-induced injury through infla
Trends Cardiovasc Med. 2026 Aug 22:S1050-1738(26)00110-6. doi: 10.1016/j.tcm.2026.08.011. Online ahead of print.ABSTRACTCurrent guidelines recommend complete revascularization for patients with multivessel disease (MVD) presenting with acute myocardial infarction (AMI); however, the optimal timing o
No abstractAm J Cardiol. 2026 Aug 22:S0002-9149(26)00529-1. doi: 10.1016/j.amjcard.2026.08.020. Online ahead of print.NO ABSTRACTPMID:42632590 | DOI:10.1016/j.amjcard.2026.08.020
Brain Res Bull. 2026 Aug 22:112089. doi: 10.1016/j.brainresbull.2026.112089. Online ahead of print.ABSTRACTBACKGROUND: The relationship between subclinical alterations in heart and brain structure and function remains poorly understood. Emerging evidence indicates that subclinical myocardial dysfunc
Ageing Res Rev. 2026 Aug 22:103295. doi: 10.1016/j.arr.2026.103295. Online ahead of print.ABSTRACTThe CC chemokine family is a group of low-molecular-weight secreted proteins that can induce various cells to migrate to specific tissues. CC chemokines are also coordinators of many cellular activities
Ageing Res Rev. 2026 Aug 22:103318. doi: 10.1016/j.arr.2026.103318. Online ahead of print.ABSTRACTWith the ageing of the global population, age-related cardiovascular diseases have become a significant burden on global public health. Traditional Chinese Medicine (TCM) possesses a deep theoretical fo
Ageing Res Rev. 2026 Aug 22:103313. doi: 10.1016/j.arr.2026.103313. Online ahead of print.ABSTRACTorating evidence from clinical studies, experimental models, and systems-level analyses, we underscore the central role of valine metabolism in cardiac dysfunction and disease progression. Finally, we e
Diabetes Res Clin Pract. 2026 Aug 22:113515. doi: 10.1016/j.diabres.2026.113515. Online ahead of print.ABSTRACTAIMS: To identify BMI trajectories after type 2 diabetes (T2D) diagnosis and examine associations with laboratory measures, medication use, comorbidities, and healthcare utilization.METHODS
JACC Adv. 2026 Aug 21;5(9):103160. doi: 10.1016/j.jacadv.2026.103160. Online ahead of print.ABSTRACTBACKGROUND: Long-term control of low-density lipoprotein cholesterol (LDL-C) is key to reducing the risk of atherosclerotic cardiovascular disease (ASCVD), yet most large-scale evaluations have been c
No abstractInt J Cardiol. 2026 Aug 22;463:134731. doi: 10.1016/j.ijcard.2026.134731. Online ahead of print.NO ABSTRACTPMID:42632336 | DOI:10.1016/j.ijcard.2026.134731
Sleep Med Rev. 2026 Aug 16;90:102355. doi: 10.1016/j.smrv.2026.102355. Online ahead of print.ABSTRACTContinuous positive airway pressure (CPAP) remains the cornerstone of obstructive sleep apnoea (OSA) treatment and can provide rapid symptomatic relief. However, long-term adherence is often suboptim
Cytokine Growth Factor Rev. 2026 Aug 18;91:139-149. doi: 10.1016/j.cytogfr.2026.08.003. Online ahead of print.ABSTRACTInterleukin-17 (IL-17) family cytokines drive protective mucocutaneous immunity and, when dysregulated, a broad spectrum of inflammatory and autoimmune disease; almost all IL-17 rece
Pathol Res Pract. 2026 Aug 17;287:156665. doi: 10.1016/j.prp.2026.156665. Online ahead of print.ABSTRACTTumor metabolic reprogramming plays a critical role in cancer progression, but how lactic acid influences tumor cell death remains incompletely understood. In this study, we investigated whether l
In response to the high metabolic resilience and immunosuppression characteristic of triple-negative breast cancer, this study established a CuGaO(2) (CGO) nano sonocatalytic platform to reshape the therapeutic landscape through a metabolic hijacking dual death cascade strategy. The ultrasound activ
J Chromatogr A. 2026 Aug 18;1786:467370. doi: 10.1016/j.chroma.2026.467370. Online ahead of print.ABSTRACTSystematic characterization of natural product components and identification of chemical markers are important prerequisites for quality control and product development. Although data dependent
Hypertens Pregnancy. 2026 Dec 31;45(1):2719498. doi: 10.1080/10641955.2026.2719498. Epub 2026 Aug 22.ABSTRACTOBJECTIVE: The impact of chronic hypertension (CHTN) combined with left ventricular hypertrophy (LVH) on adverse maternal and fetal pregnancy outcomes remains unclear.METHODS: This multicente
Ann Med. 2026 Dec;58(1):2715257. doi: 10.1080/07853890.2026.2715257. Epub 2026 Aug 22.ABSTRACTAIM: To explore the self-reported experiences of older adults with post-stroke cognitive impairment following ischemic stroke and their needs for cognitive and functional recovery, rehabilitation informatio
J Clin Hypertens (Greenwich). 2026 Aug;28(8):e70331. doi: 10.1111/jch.70331.ABSTRACTBedtime dosing of antihypertensive medications is associated with a reduction in nocturnal blood pressure (BP), but whether this effect is modified at the study level remains uncertain. We conducted an updated meta-a
