An updated patent review of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors (2020-present)

Expert Opin Ther Pat. 2026 Jun 23. doi: 10.1080/13543776.2026.2694586. Online ahead of print.ABSTRACTINTRODUCTION: Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a conserved CMGC serine/threonine kinase with an autophosphorylation-dependent activation mechanism. As a dosag

M Mennatallah Abdallah

Loneliness and social support in cardiovascular aging: a closer look at the reported positive correlation

Aging Clin Exp Res. 2026 Jun 23;38(1):156. doi: 10.1007/s40520-026-03438-9.ABSTRACTThis correspondence offers a methodological reflection on the cross-sectional study by Darabi and colleagues, which examines loneliness and social support in older Iranian adults with cardiovascular disease. The study

A Arman Abroumand Gholami

Machine learning derived abdominal aortic calcification is associated with physical frailty in community-dwelling adults: the UK Biobank Imaging Study

Geroscience. 2026 Jun 23. doi: 10.1007/s11357-026-02375-9. Online ahead of print.ABSTRACTClinical cardiovascular disease (CVD) is often present in frail individuals. However, it remains unclear whether subclinical CVD, e.g., abdominal aortic calcification (AAC), is associated with frailty. This stud

A Abadi K Gebre

Peripheral and Autonomic Diabetic Neuropathy and Their Additive Risk of Major Adverse Liver Outcomes in Type 2 Diabetes

Adv Ther. 2026 Jun 23. doi: 10.1007/s12325-026-03667-4. Online ahead of print.ABSTRACTINTRODUCTION: Type 2 diabetes (T2D) is a risk factor for the progression of liver disease, particularly relating to metabolic dysfunction-associated steatotic liver disease (MASLD), and consequent major adverse liv

A Alex E Henney

Patient health outcomes for evaluation of pharmacist-led primary care: a scoping review

Int J Clin Pharm. 2026 Jun 23. doi: 10.1007/s11096-026-02179-z. Online ahead of print.ABSTRACTINTRODUCTION: Pharmacists' role in primary care has rapidly evolved in recent years, driven by pressures on primary care and supported by increased government funding, further enabling full scope of practic

C Claire Keenan

Oligosaccharides from Polygonatum cyrtonema Hua ameliorate colitis-induced lung injury via modulation of the gut-lung axis through NF-κB and Nrf2 pathways

Nat Prod Bioprospect. 2026 Jun 23;16(1):70. doi: 10.1007/s13659-026-00608-0.ABSTRACTBACKGROUND: The gut-lung axis is a bidirectional communication network linking intestinal and pulmonary homeostasis through shared immunological and molecular mechanisms, conceptually consistent with the traditional

J Jin Xu

Biomechanically Informed Image Registration for Patient-Specific Aortic Valve Strain Analysis

Ann Biomed Eng. 2026 Jun 23. doi: 10.1007/s10439-026-04245-z. Online ahead of print.ABSTRACTPURPOSE: Aortic valve (AV) biomechanics play a critical role in maintaining normal cardiac function. Pathological variations, particularly in bicuspid valves, alter leaflet loading, increase strain, and accel

M Mohsen Nakhaei

Diagnosis and Management of Loeys-Dietz Syndrome: Evidence Gaps and Future Directions

Curr Cardiol Rep. 2026 Jun 23;28(1):61. doi: 10.1007/s11886-026-02383-3.ABSTRACTPURPOSE OF REVIEW: This review summarizes current knowledge on Loeys-Dietz syndrome (LDS), including its genetic basis, multisystem manifestations, diagnosis, surveillance, and management. It also highlights key evidence

H Hesham M Abdalla

Zinc-binding protein metallothionein 3 protects vascular smooth muscle cells from ferroptosis via blocking lysosomal degradation of GPX4

J Mol Med (Berl). 2026 Jun 23;104(1):89. doi: 10.1007/s00109-026-02696-4.ABSTRACTAortic dissection (AD) is a life-threatening vascular emergency characterized by medial degeneration and vascular smooth muscle cell (VSMC) loss. Although disruption of zinc homeostasis has been reported in patients wit

W Wenxin Lin

Relations of Life's Essential 8 score with arterial and microvascular function: The Jackson Heart Study

Vasc Med. 2026 Jun 23:1358863X261444663. doi: 10.1177/1358863X261444663. Online ahead of print.ABSTRACTBACKGROUND: The American Heart Association (AHA) Life's Essential 8 (LE8) provides a means of scoring cardiovascular health but has yet to be correlated with vascular function in an African America

A Arko S Dhar

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases

Adv Exp Med Biol. 2026;1514:299-330. doi: 10.1007/978-3-032-26629-3_11.ABSTRACTMitochondria are considered the central organelle in cellular energy metabolism and an integral platform for signal transduction. Respiratory chain complexes are the most abundant and critical protein machines in mitochon

R Runyu Guo

Semaglutide for Primary Prevention of Major Adverse Cardiac and Cerebrovascular Events in Patients with Type 2 Diabetes and Comorbid Rheumatoid Arthritis: A Target-Trial Emulation

Eur Heart J Cardiovasc Pharmacother. 2026 Jun 23:pvag044. doi: 10.1093/ehjcvp/pvag044. Online ahead of print.ABSTRACTBACKGROUND: Rheumatoid arthritis (RA)-related physical limitations often hinder sustained physical activity and weight management, thereby amplifying cardiovascular risk through adver

F Farheen Malik

Macrophage recruitment is a hallmark of non-syndromic myxomatous mitral valve disease

Cardiovasc Res. 2026 Jun 23:cvag132. doi: 10.1093/cvr/cvag132. Online ahead of print.ABSTRACTAIMS: Myxomatous mitral valve disease (MMVD) is a progressive cardiac disease characterized by extracellular matrix remodeling, leaflet thickening, and proteoglycan accumulation. Despite its significant cont

B Benjamin Le Vely

Carbon dioxide is a triple vasodilator

Cardiovasc Res. 2026 Jun 23:cvag134. doi: 10.1093/cvr/cvag134. Online ahead of print.ABSTRACTAIMS: Carbon dioxide (CO2) can regulate blood flow and is applied therapeutically in intensive care units to treat brain injury, as well as in balneotherapy for peripheral arterial disease (PAD) and diabetic

D Dragos A Duse

Global prevalence of pan-vascular diseases: A trend and health inequality analyses

Cardiovasc Res. 2026 Jun 23:cvag133. doi: 10.1093/cvr/cvag133. Online ahead of print.ABSTRACTAIMS: Pan-vascular diseases pose a significant and growing global public health burden. However, the burden of pan-vascular diseases remains unknown, especially regarding its trends through 2050.METHODS AND

J Jing Yang

Associations of the inflammasome-dependent cytokine IL-18 with risk of coronary heart disease

Cardiovasc Res. 2026 Jun 23:cvag135. doi: 10.1093/cvr/cvag135. Online ahead of print.ABSTRACTAIMS: Inflammasome activation has emerged as a promising therapeutic target to reduce residual cardiovascular risk in patients on guideline lipid-lowering therapy. IL-1β and IL-6 have been intensively studie

H Harry Björkbacka

High diagnostic yield of family echocardiographic screening of children with bicuspid aortic valve: a critical appraisal and future directions

No abstractEur Heart J Cardiovasc Imaging. 2026 Jun 23:jeag158. doi: 10.1093/ehjci/jeag158. Online ahead of print.NO ABSTRACTPMID:42334365 | DOI:10.1093/ehjci/jeag158

J Jiaqi Fan

Extending the PREVENT Equations with Cardiac MRI: Prediction of 10-year Heart Failure Risk

Radiology. 2026 Jun;319(3):e253357. doi: 10.1148/radiol.253357.ABSTRACTBackground Accurate prediction of heart failure (HF) risk is crucial for early intervention and prevention. Traditional models rely on clinical risk factors, whereas cardiac MRI parameters may offer additional predictive value. P

M Menghan Zhu

The impact of multiple long-term conditions on mortality, progression to kidney failure and health-related quality of life among people with chronic kidney disease: a multicentre cohort study (NURTuRE-CKD)

Ann Med. 2026 Dec;58(1):2692812. doi: 10.1080/07853890.2026.2692812. Epub 2026 Jun 23.ABSTRACTBACKGROUND: Multiple long-term conditions (MLTC) are common in people with chronic kidney disease (CKD). This study examined the impact of MLTC on mortality, CKD progression, and health-related quality of l

I Irene Boateng

A Randomized Trial of Interval Likelihood Ratios for Clinical Decision-Making

NEJM Evid. 2026 Jul;5(7):EVIDoa2500249. doi: 10.1056/EVIDoa2500249. Epub 2026 Jun 23.ABSTRACTBACKGROUND: Dichotomized reporting of diagnostic test results may oversimplify test characteristics. Interval likelihood ratios (ILRs), test characteristics across a range of values, offer a nuanced alternat

M Maksym Goryachok

Fulminant myocarditis complicated by acute myocardial infarction

No abstractEur Heart J. 2026 Jun 23:ehag366. doi: 10.1093/eurheartj/ehag366. Online ahead of print.NO ABSTRACTPMID:42334273 | DOI:10.1093/eurheartj/ehag366

J Jing Kang

Hormonal context and lipoprotein(a)-associated venous thromboembolism risk

No abstractEur Heart J. 2026 Jun 23:ehag493. doi: 10.1093/eurheartj/ehag493. Online ahead of print.NO ABSTRACTPMID:42334266 | DOI:10.1093/eurheartj/ehag493

D Daniel Ezzat

Diastolic dysfunction is linked to the initiation and progression of aortic stenosis: a hypothesis

Eur Heart J. 2026 Jun 23:ehag435. doi: 10.1093/eurheartj/ehag435. Online ahead of print.ABSTRACTThe conventional paradigm in aortic stenosis (AS) holds that progressive valvular obstruction increases afterload, leading to left ventricular remodelling and dysfunction. However, emerging artificial int

P Partho P Sengupta

Flame Retardant TDCIPP Reduces Heart Rate Variability Through Potential Direct Inhibition of Choline Acetyltransferase (ChAT) in Rats

J Appl Toxicol. 2026 Jun 23. doi: 10.1002/jat.70300. Online ahead of print.ABSTRACTTris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a widely used halogen-containing organophosphate flame retardant with potential neurotoxicity, but its effects on cardiac autonomic function remain largely unexplored.

J Jiuhong Zhang