Ann Intern Med. 2026 Jan 27. doi: 10.7326/ANNALS-25-01344. Online ahead of print.ABSTRACTBACKGROUND: In embarking on randomized clinical trials (RCTs), researchers can hypothesize that a more intensive treatment is better than a less intensive treatment (positive hypothesis) or that a less intensive
FASEB J. 2026 Jan 31;40(2):e71473. doi: 10.1096/fj.202502868R.ABSTRACTChronic stress is associated with inflammatory activation and oxidative stress responses leading to endothelial dysfunction, which promotes the development of atherosclerosis (AS). SGLT2 inhibitors, such as Dapagliflozin (DAPA), e
J Biochem Mol Toxicol. 2026 Feb;40(2):e70699. doi: 10.1002/jbt.70699.ABSTRACTCerebral infarction is one of the most common ischemic cerebrovascular diseases that can lead to neurological deficits. Remimazolam (RE) is a sedative agent that has been shown to improve neurological disorders. However, th
Acad Emerg Med. 2026 Jan;33(1):e70225. doi: 10.1111/acem.70225.ABSTRACTBACKGROUND: The optimal sequence of epinephrine administration and advanced airway management (AAM) successfully delivered during pediatric out-of-hospital cardiac arrest (OHCA) is unclear. Our objective was to determine whether
JMIR Form Res. 2026 Jan 26;10:e82147. doi: 10.2196/82147.ABSTRACTBACKGROUND: Informational support has been demonstrated to enhance patients' treatment adherence. However, which specific mode of informational support is more effective for patients with hypertension remains undetermined.OBJECTIVE: Th
Br Med Bull. 2026 Jan 2;157(1):ldag002. doi: 10.1093/bmb/ldag002.ABSTRACTBACKGROUND: Adipose tissue secretes bioactive substances, adipokines, which affect cardiovascular health. The secretion of adinopectines is associated with decreases in metabolic and cardiovascular diseases risk-factors such as
Stroke. 2026 Feb;57(2):292-300. doi: 10.1161/STROKEAHA.125.052995. Epub 2026 Jan 26.ABSTRACTBACKGROUND: Pregnancy-associated stroke may present with nonfocal symptoms, leading to missed diagnostic opportunities (MDO).METHODS: We conducted a retrospective study including patients aged 18 to 50 years
Stroke. 2026 Feb;57(2):312-323. doi: 10.1161/STROKEAHA.125.053999. Epub 2026 Jan 26.ABSTRACTBACKGROUND: Preeclampsia, a serious hypertensive disorder of pregnancy, is associated with increased long-term risk of cardiovascular disease in adult offspring, particularly stroke. Although low-dose aspirin
Circulation. 2026 Jan 27;153(4):266-281. doi: 10.1161/CIRCULATIONAHA.125.076308. Epub 2026 Jan 26.ABSTRACTTakayasu arteritis (TAK) is a rare, immune-mediated large-vessel vasculitis that affects predominantly young women and carries a substantial risk of both vascular complications and long-term car
No abstractCirculation. 2026 Jan 27;153(4):285-289. doi: 10.1161/CIRCULATIONAHA.125.078277. Epub 2026 Jan 26.NO ABSTRACTPMID:41587267 | DOI:10.1161/CIRCULATIONAHA.125.078277
J Vis Exp. 2026 Jan 9;(227). doi: 10.3791/69555.ABSTRACTThrombosis is a pathological condition describing the abnormal accumulation of platelets and clotting factors in a blood vessel. While many works focused on platelet activation by soluble agonists as an underlying mechanism of thrombosis, it ha
J Clin Hypertens (Greenwich). 2026 Jan;28(1):e70209. doi: 10.1111/jch.70209.ABSTRACTThe weight-adjusted waist index (WWI) is a novel indicator that could estimate body fat and muscle mass. This study aimed to investigate the relationship between WWI and hypertension plus hyperuricemia (HTN-HUA). The
J Vis Exp. 2026 Jan 9;(227). doi: 10.3791/69537.ABSTRACTPost-stroke depression (PSD) is a common, treatable complication of stroke, characterized by depressive and somatic symptoms that impair patient recovery and quality of life. This study describes a protocol combining middle cerebral artery occl
J Vis Exp. 2026 Jan 9;(227). doi: 10.3791/69305.ABSTRACTThis study presents a reproducible porcine cardiac arrest model utilizing an implantable cardioverter-defibrillator (ICD) for reliable induction and cardioversion of ventricular fibrillation (VF), as well as intracardiac ECG monitoring during r
Am J Case Rep. 2026 Jan 26;27:e950649. doi: 10.12659/AJCR.950649.ABSTRACTBACKGROUND Device embolization is a rare complication of percutaneous closure of paravalvular leaks after transcatheter, surgical aortic, or mitral valve replacement. Management typically involves surgical or endovascular inter
J Vis Exp. 2026 Jan 9;(227). doi: 10.3791/68831.ABSTRACTAcute diffuse retinal hemorrhage is a rare but potentially serious complication following intravitreal anti-vascular endothelial growth factor (anti-vascular endothelial growth factor [VEGF]) therapy. Conbercept, a recombinant fusion protein, h
Clin J Am Soc Nephrol. 2026 Jan 26. doi: 10.2215/CJN.0000000994. Online ahead of print.ABSTRACTBACKGROUND: We recently developed and validated a hierarchical composite endpoint (HCE) for chronic kidney disease (CKD) progression combining time-to-event kidney outcomes with the rate of estimated glome
Blood. 2026 Jan 26:blood.2025029834. doi: 10.1182/blood.2025029834. Online ahead of print.ABSTRACTPlasminogen activator inhibitor 1 (PAI-1) is an inhibitor of fibrinolysis, thereby promoting blood clot stabilization. PAI-1 contributes to thrombosis, diet-induced obesity, and age-associated diseases
Am J Physiol Lung Cell Mol Physiol. 2026 Feb 1;330(2):L169-L177. doi: 10.1152/ajplung.00239.2025.ABSTRACTExtracellular vesicles (EVs) containing cyclic adenosine monophosphate (cAMP-EVs) activate signaling based on protein kinase A in recipient endothelial cells, but limited information is available
JAMA Intern Med. 2026 Jan 26. doi: 10.1001/jamainternmed.2025.7453. Online ahead of print.ABSTRACTIMPORTANCE: Gout is associated with increased cardiovascular risk. Whether achieving a target serum urate level lower than 6 mg/dL with urate-lowering treatment (ULT) would reduce cardiovascular risk in
Hepatol Res. 2026 Jan 26. doi: 10.1111/hepr.70127. Online ahead of print.ABSTRACTAIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by the presence of hepatic steatosis and at least one of five cardiometabolic risk factors, leading to the development of cardiovas
Sci China Life Sci. 2026 Jan 15. doi: 10.1007/s11427-025-3187-4. Online ahead of print.ABSTRACTElevated blood low-density lipoprotein (LDL) levels are a major risk factor for cardiovascular disease. Increasing LDL receptor (LDLR) expression effectively reduces blood LDL and serves as a key therapeut
CVIR Endovasc. 2026 Jan 26;9(1):10. doi: 10.1186/s42155-026-00655-1.ABSTRACTBACKGROUND: Endovascular therapy (EVT) for aortoiliac (AI) disease has shown favorable outcomes with recent advances in technology. Furthermore, the transradial approach (TRA) has emerged as a less invasive alternative to tr
Phys Eng Sci Med. 2026 Jan 26. doi: 10.1007/s13246-026-01699-2. Online ahead of print.ABSTRACTCongestive heart failure (CHF) is a cardiovascular disease that poses a serious threat to human health. Electrocardiogram (ECG) signals can be used to detect heart diseases such as CHF. However, the low amp
