Systemic implications of osteoarthritis: from local degeneration to systemic metabolic Dysregulation
J Transl Med. 2026 May 25. doi: 10.1186/s12967-026-08277-w. Online ahead of print.ABSTRACTBACKGROUND: Traditionally viewed as a localized "wear-and-tear" pathology, osteoarthritis (OA) is now increasingly recognized as a complex systemic disorder driven by metabolic and inflammatory dysregulation. T

