National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data

JAMA. 2026 Mar 22. doi: 10.1001/jama.2026.3100. Online ahead of print.ABSTRACTIMPORTANCE: Pediatric sepsis causes substantial morbidity and mortality, but population surveillance relies on administrative codes with limited and variable accuracy.OBJECTIVE: To estimate US national incidence, mortality

C Chanu Rhee

Quercetin and nanoquercetin mitigate high fat diet-induced obesity via lipid modulation, genomic DNA integrity restoration, adipokine regulation, and hepato-pancreatic tissue preservation

Sci Rep. 2026 Mar 22. doi: 10.1038/s41598-026-41808-5. Online ahead of print.ABSTRACTObesity is a global health challenge characterized by excessive fat accumulation and associated with life-threatening comorbidities such as type 2 diabetes, cardiovascular diseases, and certain cancers. Conventional

M Marwa A Lotify

AISF practice guidance on pharmacological treatment of metabolic-dysfunction associated steatotic liver disease and steatohepatitis (MASLD/MASH): A 2026 Update

Dig Liver Dis. 2026 Mar 20:S1590-8658(26)00292-6. doi: 10.1016/j.dld.2026.02.014. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) has rapidly emerged as the leading cause of chronic liver disease worldwide, gradually replacing viral hepatitis in clinica

A Associazione Italiana per lo Studio del Fegato (AISF)

Angiography-derived fractional flow reserve versus coronary angiography to guide coronary artery bypass grafting in patients undergoing surgical valve procedures with concomitant coronary artery disease in China (FAVOR IV-QVAS): a multicentre, triple-blind, randomised trial

Lancet. 2026 Mar 21;407(10534):1161-1170. doi: 10.1016/S0140-6736(25)02418-3.ABSTRACTBACKGROUND: For patients undergoing surgical valve procedures with concomitant coronary artery disease, current guidelines recommend that coronary artery bypass grafting (CABG) should be anatomically guided on the b

Y Yunpeng Zhu

From canes to pills: the evolution of carbon monoxide therapeutics

Adv Drug Deliv Rev. 2026 Mar 19:115858. doi: 10.1016/j.addr.2026.115858. Online ahead of print.ABSTRACTCarbon monoxide (CO) has gained increasing attention as an endogenous gasotransmitter with potential therapeutic relevance. In preclinical studies, including acute lung injury, sepsis, transplantat

F Fiona Halbig

Socio-economic influences from egg to exit: emerging biology

Ageing Res Rev. 2026 Mar 19:103104. doi: 10.1016/j.arr.2026.103104. Online ahead of print.ABSTRACTSocio-economic status (SES) impacts life-long health from early development to old age. We review SES differences in biological factors that begin before fertilization and extend into later life, 'egg t

M Marja Jylhä