Reliability and validation of the German WHOQOL-BREF in adults with congenital heart disease
No abstractQual Life Res. 2026 May 3;35(6):149. doi: 10.1007/s11136-026-04253-5.NO ABSTRACTPMID:42070205 | DOI:10.1007/s11136-026-04253-5
Quality of life after tranexamic acid in subarachnoid hemorrhage: post-hoc analysis of the ULTRA trial
Qual Life Res. 2026 May 3;35(6):148. doi: 10.1007/s11136-026-04263-3.ABSTRACTPURPOSE: The ULTRA trial evaluated the impact of ultra-early and short-term tranexamic acid (TXA) treatment in patients with subarachnoid hemorrhage (SAH) and found no clinical benefit at six months. This post-hoc analysis
A human endothelial and adipose stem cell-based co-culture model for venous malformations
No abstractAngiogenesis. 2026 May 3;29(3):30. doi: 10.1007/s10456-026-10045-9.NO ABSTRACTPMID:42070175 | DOI:10.1007/s10456-026-10045-9
Evolving biopsy strategies for molecular profiling of brain arteriovenous malformations
Angiogenesis. 2026 May 3;29(3):26. doi: 10.1007/s10456-026-10041-z.ABSTRACTBrain arteriovenous malformations (BAVMs) are increasingly recognized as dynamic vascular diseases driven by endothelial genetic alterations and dysregulated signaling pathways, rather than as static structural anomalies. Acc
Loss of Chromosome Y Associates With Altered Immune Cell Trajectories and X-Inactivation Features
Aging Cell. 2026 May;25(5):e70528. doi: 10.1111/acel.70528.ABSTRACTThe loss of chromosome Y (LOY) in leukocytes is the most prevalent form of clonal mosaicism observed in older men. Previous studies provided multiple pieces of evidence for the effect of LOY on the immune system and connected LOY to
Valve-in-Valve Transcatheter Mitral Valve Replacement Versus Redo Surgical Mitral Valve Replacement: Meta-Analysis of Early and Late Outcomes
J Am Heart Assoc. 2026 May 3:e050299. doi: 10.1161/JAHA.126.050299. Online ahead of print.ABSTRACTBACKGROUND: Bioprosthetic mitral valve degeneration is traditionally treated with redo surgical mitral valve replacement (redo-SMVR), but valve-in-valve transcatheter mitral valve replacement (ViV-TMVR)
Lactic acid bacteria and endogenous ethanol mediate proton pump inhibitor-associated MASLD: a multicohort cross-sectional mediation analysis
Gut Microbes. 2026 Dec 31;18(1):2664712. doi: 10.1080/19490976.2026.2664712. Epub 2026 May 3.ABSTRACTBACKGROUND & AIMS: Proton pump inhibitor (PPI) use has been associated with metabolic dysfunction associated with steatotic liver disease (MASLD) in multiple studies. While the association is confoun
Triple-valve replacement in repaired tetralogy of fallot patients with mirror-image dextrocardia: a case report
J Cardiothorac Surg. 2026 May 2. doi: 10.1186/s13019-026-04146-1. Online ahead of print.ABSTRACTBACKGROUND: The co-occurrence of mirror-image dextrocardia and tetralogy of Fallot (TOF) is a rare congenital condition. Reoperative multivalve surgery in such patients, especially after repaired TOF, pre
Formulation-Specific Cardiovascular Outcomes with High-Dose Eicosapentaenoic Acid: A Systematic Review and Meta-analysis
Am J Cardiovasc Drugs. 2026 May 2. doi: 10.1007/s40256-026-00798-5. Online ahead of print.ABSTRACTBACKGROUND/OBJECTIVE: Residual cardiovascular risk persists despite intensive statin therapy in patients with established atherosclerotic cardiovascular disease (CVD). Omega-3 fatty acids, particularly
Medicinal Plants and the Gastrointestinal Microbiota in Chronic Diseases Modulation: A Structured Mechanistic and Translational Review
Curr Microbiol. 2026 May 2;83(6):346. doi: 10.1007/s00284-026-04940-z.ABSTRACTThe gut microbiome supports digestion, immunity, and metabolism; its imbalance (dysbiosis) drives inflammation and metabolic dysfunction, contributing to chronic diseases such as diabetes, cardiovascular disease, inflammat
Dialysis-associated cardiovascular disease risk in children: mechanism and management
Pediatr Nephrol. 2026 May 2. doi: 10.1007/s00467-026-07310-w. Online ahead of print.ABSTRACTDespite modest improvement, the lifespan of a child on dialysis continues to be 40 years shorter compared to healthy children. Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in t
Emergency reversal of Rivaroxaban with Andexanet alfa in a child with hemorrhagic brain metastasis from Wilms tumor
Childs Nerv Syst. 2026 May 2;42(1):195. doi: 10.1007/s00381-026-07286-w.ABSTRACTBACKGROUND: Central nervous system (CNS) metastases from Wilms tumor (WT) are exceedingly rare. Intracerebral hemorrhage secondary to metastatic WT is even less common, and the management of such cases is further complic
Obesity paradox in young with myocardial infarction in China - or is this really a lean paradox?
No abstractInt J Obes (Lond). 2026 May 2. doi: 10.1038/s41366-026-02096-1. Online ahead of print.NO ABSTRACTPMID:42069939 | DOI:10.1038/s41366-026-02096-1
Cardiorespiratory tolerance of continuous dexmedetomidine infusion in preterm and term newborn infants: a retrospective cohort study
Eur J Pediatr. 2026 May 2;185(5):337. doi: 10.1007/s00431-026-07000-7.ABSTRACTDexmedetomidine (DEX) is increasingly used for neonatal sedation, but safety data remain limited. We conducted a single-center retrospective study including neonates receiving continuous DEX infusion. Cardiorespiratory eve
Multi-trait GWAS reveals divergent local and polygenic architecture of cardiovascular traits across African and European ancestries in the UK Biobank
Commun Biol. 2026 May 2. doi: 10.1038/s42003-026-09977-1. Online ahead of print.ABSTRACTThe genetic architecture of cardiovascular traits is poorly characterised in non-European populations, limiting our understanding of disease aetiology and contributing to health disparities. Here, we analyse the
Multicohort analysis unveils axon guidance pathways linking small for gestational age to spirometric restriction
Nat Commun. 2026 May 2. doi: 10.1038/s41467-026-72490-w. Online ahead of print.ABSTRACTChildren born small for gestational age (SGA) face elevated risks of metabolic, cardiovascular, respiratory, and neurodevelopmental disorders, as well as premature mortality, yet the underlying mechanisms remain o
Joint association of atherogenic index of plasma and estimated glucose disposal rate with new-onset cardiovascular disease risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a 9-year nationwide prospective cohort study
Cardiovasc Diabetol. 2026 May 2. doi: 10.1186/s12933-026-03200-5. Online ahead of print.ABSTRACTBACKGROUND: The atherogenic index of plasma (AIP) and estimated glucose disposal rate (eGDR) are two composite indices derived from routine metabolic measurements and are associated with cardiocerebrovasc
Lipid levels and risk-stratified management gaps of dyslipidemia in China
BMC Med. 2026 May 2. doi: 10.1186/s12916-026-04904-x. Online ahead of print.ABSTRACTBACKGROUND: Dyslipidemia remains a major modifiable contributor to China's cardiovascular disease (CVD) burden, yet large-scale evidence on risk-stratified management gaps is lacking.METHODS: In this nationwide study
Nanomedicine-based theranostics in atherosclerotic cardiovascular diseases
J Biomed Sci. 2026 May 2;33(1):43. doi: 10.1186/s12929-026-01245-y.ABSTRACTCurrent treatment for atherosclerotic cardiovascular diseases (ASCVD) mainly focuses on the modification of systemic risk factors, such as hyperglycemia and hyperlipidemia. Despite significant efforts and expanse, achieving e
Senescence dynamics define therapeutic windows for Duchenne muscular dystrophy in DBA/2-mdx mice
Skelet Muscle. 2026 May 2. doi: 10.1186/s13395-026-00426-5. Online ahead of print.ABSTRACTBACKGROUND: Duchenne muscular dystrophy (DMD) is a severe X-linked disorder marked by progressive muscle degeneration and regeneration, inflammation and fibrosis. Cellular senescence has emerged as a potential
Prevalence and clinical correlates of hypertension among patients with type 2 diabetes in Spanish primary care: a cross-sectional study
BMC Prim Care. 2026 May 2. doi: 10.1186/s12875-026-03354-x. Online ahead of print.ABSTRACTBACKGROUND: Hypertension is common among patients with type 2 diabetes mellitus (T2DM) and represents a major contributor to cardiovascular and renal morbidity. Real-world data from primary care are essential t
Vascular ultrasound-based risk stratification model for atherosclerotic cardiovascular disease in patients with type 2 diabetes mellitus
BMC Med Imaging. 2026 May 2. doi: 10.1186/s12880-026-02340-0. Online ahead of print.ABSTRACTBACKGROUND: This study aimed to investigate the ability of an ultrasound-based risk stratification model integrating carotid intima thickness (CIT) and carotid-femoral pulse wave velocity (cfPWV) to aid in ri
Efficacy of Valsartan-HCTZ in hypertension: a cohort study exploring age as a key determinant
BMC Cardiovasc Disord. 2026 May 2. doi: 10.1186/s12872-026-05900-y. Online ahead of print.ABSTRACTBACKGROUND: Hypertension is a major global public health challenge, and effective management of antihypertensive treatment response is crucial. This study aimed to analyze the demographic, clinical, and
Clinical characteristics, frailty, and one-year survival outcomes in centenarian patients presenting to the emergency department
BMC Geriatr. 2026 May 2. doi: 10.1186/s12877-026-07593-6. Online ahead of print.ABSTRACTBACKGROUND: Centenarian patients constitute a rapidly growing yet understudied population in emergency medicine. Evidence regarding prognostic factors and one-year outcomes in individuals aged 100 years and older