Chamber-specific regulation of myofilament Ca2+ sensitivity by nNOSβ via troponin I phosphorylation: Predominance in the right ventricle

J Gen Physiol. 2026 Nov 2;158(6):e202613982. doi: 10.1085/jgp.202613982. Epub 2026 Oct 5.ABSTRACTNeuronal nitric oxide (NO) synthase (nNOS) is an important regulator of excitation-contraction coupling in cardiomyocytes, yet its chamber-specific role in right ventricular cardiomyocytes (RVCMs) remain

J Jae Won Kwon

Emerging therapeutic strategies to target APOE4 in Alzheimer's disease

FEBS J. 2026 Oct 5. doi: 10.1111/febs.70759. Online ahead of print.ABSTRACTThe apolipoprotein E ε4 (APOE4) allele is the strongest common genetic risk factor for late-onset Alzheimer's disease. However, its incomplete penetrance supports the view that it acts as a modifiable systems-level perturbati

W Wei I Jiang

Children with X-linked hypophosphatemia have hypertension and left ventricular hypertrophy associated with obesity

J Bone Miner Res. 2026 Oct 5:zjag142. doi: 10.1093/jbmr/zjag142. Online ahead of print.ABSTRACTINTRODUCTION: X-linked Hypophosphatemia (XLH) is a genetic condition of renal phosphate wasting with multisystem complications. Children and adults with XLH have increased frequency of obesity, a risk fact

C Chelsey Grimbly

Hypoxia Combined With Substance P Pretreatment of ADSC-Exos Promotes Recruitment and Differentiation of EPCs by Activating YAP/TEAD3 to Treat Diabetic Foot Ulcer

FASEB J. 2026 Oct 15;40(19):e72271. doi: 10.1096/fj.202600274R.ABSTRACTDiabetic ulcers are associated with high amputation and mortality rates, significantly impacting patients' life quality. Both hypoxia and substance P (SP) treated-ADSC-Exos promote wound healing and angiogenesis in diabetic foot

X Xitao Peng

Albumin for patients with acute large vessel occlusive stroke undergoing endovascular therapy-2 (ARISE-2): protocol for a randomised controlled trial

Eur Stroke J. 2026 Oct 5;11(10):aakag119. doi: 10.1093/esj/aakag119.ABSTRACTBACKGROUND: Endovascular therapy is the standard of care for eligible patients with acute ischemic stroke due to LVO. However, nearly half of patients remain functionally dependent even after successful reperfusion. Albumin

Z Zilin Xu

Early change and new onset of vascular pathology in cervical artery dissection: implications for surveillance

Eur Stroke J. 2026 Oct 5;11(10):aakag117. doi: 10.1093/esj/aakag117.ABSTRACTINTRODUCTION: Antithrombotic therapy is central to stroke prevention after spontaneous cervical artery dissection (sCAD), but its efficacy may depend on the underlying vascular morphology. We examined the temporal course of

R Robin Seihu

Comparison of oral and gut microbiome highlights the role of oral bacteria in systemic inflammation in HIV

mSphere. 2026 Oct 5:e0038426. doi: 10.1128/msphere.00384-26. Online ahead of print.ABSTRACTChronic HIV-1 infection is associated with increased inflammation-related comorbidities, despite effective viral suppression with antiretroviral therapy. While the role of the gut microbiome in inflammation is

J Jennifer A Fulcher

Development and Validation of Two Analytical Methods Using High-Performance Liquid Chromatography and Atomic Absorption Spectroscopy for the Analysis of Tunisian Marketed Pharmaceutical Product-Based Insulin and Zinc: Application in Routine Stability Study

Biomed Chromatogr. 2026 Nov;40(11):e70585. doi: 10.1002/bmc.70585.ABSTRACTGiven the widespread reliance on insulin among diabetic patients, ensuring its stability is an essential task not only for preserving its therapeutic efficacy but also for safeguarding patient health and safety. In addition, i

M Majdi Ben Messaoud

A Clinical Insight into Von Hippel-Lindau Syndrome: Diagnostic Challenges

Prague Med Rep. 2026;127(3):211-214. doi: 10.14712/23362936.2026.27.ABSTRACTVon Hippel-Lindau (VHL) syndrome is a rare hereditary disorder characterised by the development of multiple benign and malignant tumours across various organs. Caused by mutations in the VHL tumour suppressor gene, it presen

G Giulia Andreia Curvelo Rosado

Innovative hydrogel systems for antioxidant and cardiac protection after myocardial infarction: addressing Ferrostatin-1 solubility and retention challenges

J Mater Chem B. 2026 Sep 25. doi: 10.1039/d6tb00963h. Online ahead of print.ABSTRACTMyocardial infarction (MI) triggers severe oxidative stress and ferroptosis, leading to progressive cardiomyocyte death and impaired cardiac function. Inhibiting ferroptosis in ischemic myocardium with Ferrostatin-1

X Xu Yang

Body roundness index, frailty, and prevalent self-reported stroke: An exploratory cross-sectional decomposition analysis

Ann Acad Med Singap. 2026 Sep 7;55(9):404-414. doi: 10.47102/annals-acadmedsg.2025312.ABSTRACTINTRODUCTION: This study aimed to compare the clinical outcomes of endoscopic combined intrarenal surgery (ECIRS) in the prone hip-flexed split-leg position with conventional percutaneous nephrolithotomy (P

D Desheng Zhu

Geospatial approaches to analysing spatial patterns of stroke incidence and mortality: a systematic review

Geospat Health. 2026 Jul 23;21(2). doi: 10.4081/gh.2026.1486. Epub 2026 Oct 5.ABSTRACTStroke is a leading cause of mortality and disability worldwide; however, its burden is unevenly distributed across geographical areas. This systematic review aimed to synthesise studies examining the spatial distr

M Min-Jung Kim

Acute effects of volume-matched isometric exercise intensity on vascular function and autonomic regulation in men with elevated blood pressure

Clin Physiol Funct Imaging. 2026 Nov;46(6):e70093. doi: 10.1111/cpf.70093.ABSTRACTIsometric exercise (IE) has been introduced as an effective non-pharmacological strategy for blood pressure (BP) management; however, the influence of exercise intensity remains unclear during lower-limb IE. This study

M Min Ji Jeong

Redirecting full-length FLT1 expression towards its soluble isoform by targeting alternative polyadenylation promotes postischaemic angiogenesis

Cardiovasc Res. 2026 Oct 5:cvag198. doi: 10.1093/cvr/cvag198. Online ahead of print.ABSTRACTAIMS: Vascular endothelial growth factors (VEGFs) and their endothelial tyrosine kinase receptors are crucial mediators of vasculogenesis and angiogenesis, with FLT1 (VEGFR1) acting as a decoy receptor for VE

M Maja Bundalo

Role of Telemedicine in Congenital Heart Disease Care Models in Low- and Middle-Income Countries: A Scientific Statement From the American Heart Association

J Am Heart Assoc. 2026 Oct 5:e054084. doi: 10.1161/JAHA.126.054084. Online ahead of print.ABSTRACTTelemedicine is increasingly recognized as a transformative strategy to address critical challenges in low- and middle-income countries, which comprise 63% of all nations, 84% of the global population,

S Sandra S Mattos

Screening Strategies for Silent Myocardial Ischemia in Individuals With Diabetes Without Known Coronary Artery Disease: Systematic Review and Meta-Analysis

Clin Cardiol. 2026 Oct;49(10):e70470. doi: 10.1002/clc.70470.ABSTRACTINTRODUCTION: Diabetes mellitus markedly increases atherosclerotic cardiovascular risk, and coronary artery disease remains a leading cause of morbidity and mortality. Silent myocardial ischemia (SMI) is clinically relevant in diab

V Vanessa Del Carmen Romero Martínez

Original thrombectomy combined with stenting for symptomatic internal carotid artery stenosis in early period of ischemic stroke

Khirurgiia (Mosk). 2026;(10):109-116. doi: 10.17116/hirurgia2026101109.ABSTRACTOptimizing the treatment of ischemic stroke is an urgent task in modern medicine. One of its causes is acute thrombosis of internal carotid artery due to atherosclerotic lesion. Conventional thrombolysis is effective only

B B S Sukovatykh

Impact of anesthesia type on results of carotid endarterectomy: analytical review of randomized clinical trials

Khirurgiia (Mosk). 2026;(10):85-89. doi: 10.17116/hirurgia202610185.ABSTRACTSearching for optimal anesthesia type in patients undergoing carotid endarterectomy (CEA) has been ongoing since the origin of carotid surgery. Nevertheless, there is still no consensus on this issue. This review of randomiz

P P A Khodzhiboev

Invasive interventions for asymptomatic stenotic internal carotid artery lesions in paradigm of modern optimal drug therapy

Khirurgiia (Mosk). 2026;(10):80-84. doi: 10.17116/hirurgia202610180.ABSTRACTInternal carotid artery ostium is the most common localization of stenotic lesions of extracranial arteries. Stroke in carotid basin usually follows acute occlusion of internal carotid artery as a result of atherosclerotic p

A A V Bocharov

Current knowledge of pathophysiology of ischemia-induced intestinal wall damage: comprehensive analysis of pathogenesis and perspectives

Khirurgiia (Mosk). 2026;(10):71-79. doi: 10.17116/hirurgia202610171.ABSTRACTIntestinal ischemia is still one of the most complex pathological processes and characterized by high mortality and difficulties in early diagnosis. The article presents modern data on pathophysiological mechanisms of ischem

A A A Atayan

Risk factors and algorithm for choosing abdominal closure strategy in staged treatment of penetrating wounds

Khirurgiia (Mosk). 2026;(10):43-50. doi: 10.17116/hirurgia202610143.ABSTRACTOBJECTIVE: To analyze the influence of local and systemic factors on reparative processes of laparotomy wound for optimized choice of abdominal closure strategy.MATERIAL AND METHODS: A retrospective analysis enrolled 62 pati

I I V Paharev

Caprini Risk Score validity and prevention of venous thromboembolism in emergency surgery

Khirurgiia (Mosk). 2026;(10):33-42. doi: 10.17116/hirurgia202610133.ABSTRACTOBJECTIVE: To evaluate validity of the Caprini Risk Score (CRS) for predicting postoperative venous thromboembolism (VTE) in emergency surgery, as well as to investigate the impact of compliance with prophylactic protocols o

S S E Krylov

Results of revascularization operations in geriatric patients with multifocal atherosclerosis

Khirurgiia (Mosk). 2026;(10):21-32. doi: 10.17116/hirurgia202610121.ABSTRACTBACKGROUND: Multifocal atherosclerosis (MFA) is one of the common diseases in elderly patients. Currently, there is no single approach to treating patients with MFA. The active implementation of endovascular surgery has sign

Z Z A Kavteladze

Carotid endarterectomy under regional or general anesthesia - two methods of anesthesia in a multi-field hospital

Khirurgiia (Mosk). 2026;(10):12-20. doi: 10.17116/hirurgia202610112.ABSTRACTOBJECTIVE: To define the impact of anaesthesia (general [GA] vs. regional [RA]) on results of carotid endarterectomy (CEA).MATERIAL AND METHODS: There were 1732 CEAs in 2012-2025. CEA under RA was performed in 1153 cases, CE

A A I Khripun