Exp Suppl. 2026;115:199-213. doi: 10.1007/978-3-032-06948-1_7.ABSTRACTSmall, endogenous noncoding RNAs known as miRNAs are widely distributed and use posttranscriptional control to suppress the expression of target genes. miRNAs have crucial roles in the development of disease and carcinogenesis, an
Exp Suppl. 2026;115:31-87. doi: 10.1007/978-3-032-06948-1_2.ABSTRACTFor a long time, noncoding RNAs (ncRNAs) were considered irrelevant fragments of the genome, dismissed as genetic noise. However, recent breakthroughs have unveiled their crucial Role in regulating gene expression, influencing funda
Adv Exp Med Biol. 2026;1490:373-381. doi: 10.1007/978-3-032-03402-1_39.ABSTRACTGenome-wide association studies (GWAS) have revolutionized our understanding of genetic contributions to complex diseases by identifying single-nucleotide polymorphisms (SNPs) associated with disease predisposition. Despi
Adv Exp Med Biol. 2026;1490:67-80. doi: 10.1007/978-3-032-03402-1_8.ABSTRACTBACKGROUND: The most common genetic cause associated with thrombophilia is Leiden mutation (G1691A) of the coagulation factor V (FV) (F5) gene.MATERIALS AND METHODS: Data collected anonymously from 355 unrelated Greeks exami
Adv Exp Med Biol. 2026;1500:27-48. doi: 10.1007/978-3-032-12741-9_2.ABSTRACTPrenatal alcohol exposure (PAE) is recognized as a teratogenic factor that affects neural development, resulting in a range of structural, functional, and cognitive/behavioral abnormalities contributing to the pathogenesis o
Nat Rev Cardiol. 2026 Jan 2. doi: 10.1038/s41569-025-01234-y. Online ahead of print.ABSTRACTUraemic cardiomyopathy is a term widely used to describe the severe myocardial disease characterized by left ventricular hypertrophy and diffuse interstitial fibrosis that occurs in kidney failure. The causat
Nat Rev Cardiol. 2026 Jan 2. doi: 10.1038/s41569-025-01244-w. Online ahead of print.ABSTRACTThe prevalence of frailty and its effect on cardiovascular outcomes is increasing on a global scale. Pharmacotherapies for cardiovascular diseases in older people with frailty present unique challenges that r
Nat Rev Cardiol. 2026 Jan 2. doi: 10.1038/s41569-025-01229-9. Online ahead of print.ABSTRACTThe discovery of non-coding RNAs has expanded our understanding of how genetic features are linked to cellular function. The illumination of this so-called dark matter of the genome has revealed new categorie
Nat Rev Cardiol. 2026 Jan 2. doi: 10.1038/s41569-025-01233-z. Online ahead of print.ABSTRACTTricuspid regurgitation is associated with an increased risk of hospitalization and death. Many patients with severe tricuspid regurgitation are unable to undergo surgical intervention owing to prohibitive te
Nat Rev Cardiol. 2026 Jan 2. doi: 10.1038/s41569-025-01223-1. Online ahead of print.ABSTRACTGenetic and acquired forms of heart disease are leading causes of death worldwide. The epigenome, which governs cellular identity by modulating the accessibility of genetic regulatory elements, is established
J Prev Alzheimers Dis. 2026 Jan 1:100448. doi: 10.1016/j.tjpad.2025.100448. Online ahead of print.ABSTRACTBACKGROUND: The global prevalence of dementia is rapidly expanding and is expected to triple by 2050. Approximately 45 % of dementia cases are estimated to be attributable to potentially modifia
No abstractEBioMedicine. 2025 Dec 31:106097. doi: 10.1016/j.ebiom.2025.106097. Online ahead of print.NO ABSTRACTPMID:41478759 | DOI:10.1016/j.ebiom.2025.106097
Nutr Metab Cardiovasc Dis. 2025 Nov 28:104478. doi: 10.1016/j.numecd.2025.104478. Online ahead of print.ABSTRACTBACKGROUND AND AIM: Reduction in liver fibrosis, as assessed by liver stiffness measurement (LSM) on serial vibration-controlled transient elastography (VCTE) examinations, may have benefi
Nutr Metab Cardiovasc Dis. 2025 Nov 20:104468. doi: 10.1016/j.numecd.2025.104468. Online ahead of print.ABSTRACTBACKGROUND AND AIM: Tryptophan's metabolic products, serotonin and melatonin, exhibit antioxidant activity and neuroprotective properties, thereby preventing mortality from cardiovascular
Nutr Metab Cardiovasc Dis. 2025 Nov 27:104475. doi: 10.1016/j.numecd.2025.104475. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Evidence on the association of Body Roundness Index (BRI), an anthropometric indicator of body fat and visceral adiposity, with cardiometabolic multimorbidity (CMM) re
ACS Biomater Sci Eng. 2026 Jan 1. doi: 10.1021/acsbiomaterials.5c00766. Online ahead of print.ABSTRACTThe study explores the innovative application of stereolithography to address key material and technological limitations in left ventricular assist devices. Currently, the invasiveness of left ventr
ACS Nano. 2026 Jan 1. doi: 10.1021/acsnano.5c18629. Online ahead of print.ABSTRACTThe dysregulation of the hepatocyte growth factor/c-mesenchymal-epithelial transition factor (HGF/c-Met) signaling pathway stimulates an invasive epithelial-mesenchymal transition (EMT) and establishes a pathogenic fee
J Matern Fetal Neonatal Med. 2026 Dec;39(1):2603040. doi: 10.1080/14767058.2025.2603040. Epub 2026 Jan 1.ABSTRACTOBJECTIVE: To investigate fetal intrahepatic umbilical-portal-systemic venous shunts (IHUPSVS).METHODS: The study retrospectively analyzed cases of IHUPSVS at a single center from January
J Pharmacol Exp Ther. 2025 Dec;392(12):103695. doi: 10.1016/j.jpet.2025.103695.ABSTRACTDespite advances in therapies that target low-density lipoprotein (LDL), atherosclerotic cardiovascular disease (ASCVD) remains a major cause of morbidity and mortality. This has led to the investigation of other
J Pharmacol Exp Ther. 2025 Dec;392(12):103556. doi: 10.1016/j.jpet.2025.103556.ABSTRACTRenal fibrosis is the hallmark and final common pathway of chronic kidney disease. Matrix metalloproteinases (MMPs) are zinc-dependent enzymes that cleave bioactive molecules to maintain extracellular matrix homeo
J Pharmacol Exp Ther. 2025 Dec;392(12):103696. doi: 10.1016/j.jpet.2025.103696.ABSTRACTCardiovascular disease (CVD) remains the leading cause of death worldwide despite decades of therapeutic advances. Emerging insights into its etiology have revealed previously unappreciated cellular and molecular
Ren Fail. 2025 Dec;47(1):2604881. doi: 10.1080/0886022X.2025.2604881. Epub 2026 Jan 1.ABSTRACTRecent advancements in transplant techniques and immunosuppressive drugs have improved long-term survival rates and increased the age of transplant recipients. Dyslipidemia has become a major complication,
J Pain. 2025 Dec 30:106182. doi: 10.1016/j.jpain.2025.106182. Online ahead of print.ABSTRACTPain is highly prevalent among older adults with cardiovascular disease (CVD) and may compromise functional independence. However, the nature of this relationship in different cultural and healthcare contexts
Respir Med. 2025 Dec 30:108628. doi: 10.1016/j.rmed.2025.108628. Online ahead of print.ABSTRACTChronic Obstructive Pulmonary Disease (COPD) and Heart failure (HF) are often concomitant, they are overlooked in practice. The objectives of this study were to determine the prevalence of HF in diagnosed
