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Cardiovascular disease

Targeting endothelial cytoskeletal remodeling to restore angiogenesis in ischemic heart disease

Biomed Pharmacother. 2026 Jun 11;201:119650. doi: 10.1016/j.biopha.2026.119650. Online ahead of print.ABSTRACTIschemic heart disease (IHD) remains a leading cause of morbidity and mortality worldwide. Effective restoration of myocardial perfusion relies on angiogenesis, a process frequently impaired

Y Yan Shu

Pathological Insights Into the Relationship Between Medial and Intimal Calcification in Lower Extremity Artery Disease

JACC Adv. 2026 Jun 11;5(7):102882. doi: 10.1016/j.jacadv.2026.102882. Online ahead of print.ABSTRACTBACKGROUND: Medial artery calcification (MAC) is a hallmark of lower extremity artery disease, yet its precise distribution and relationship with intimal artery calcification (IAC) remain poorly under

T Tsukasa Kato

Safety and Outcomes of Concomitant Left Atrial Appendage Occlusion and Atrial Fibrillation Ablation

JACC Adv. 2026 Jun 11;5(7):102870. doi: 10.1016/j.jacadv.2026.102870. Online ahead of print.ABSTRACTBACKGROUND: Performing atrial fibrillation (AF) catheter ablation and percutaneous left atrial appendage occlusion (LAAO) during a single procedure may improve efficiency and reduce cumulative procedu

K Khalid Sawalha

Changes in life expectancy in Aotearoa New Zealand: a cause-specific decomposition analysis over 20 years

N Z Med J. 2026 Jun 12;139(1636):87-101. doi: 10.26635/6965.7486.ABSTRACTAIMS: Life expectancy in Aotearoa New Zealand has increased over recent decades, but these increases have not been distributed equally across population groups. Examining how changes in cause-specific mortality have contributed

M Mazin Ghafel

Diversity, equity and inclusion in arrhythmia care: A European Heart Rhythm Association survey

Europace. 2026 Jun 11:euag144. doi: 10.1093/europace/euag144. Online ahead of print.ABSTRACTBACKGROUND: Disparities in arrhythmia care are increasingly recognised, yet remain incompletely characterised across the patient pathway. This European Heart Rhythm Association (EHRA) survey explored clinicia

M Mark T Mills

Phytochemical Profiling, Antiplatelet Potential, and Cytotoxic Assessment of Thymelaea tartonraira Aerial Part Essential Oil: In Vitro and In Silico Studies

Chem Biodivers. 2026 Jun;23(6):e71401. doi: 10.1002/cbdv.71401.ABSTRACTThis study evaluates the antiplatelet potential of Thymelaea tartonraira essential oil, obtained from aerial parts by hydrodistillation. GC-MS analysis identified 43 compounds, with phenethyl alcohol (25.69%), eugenol (12.42%), a

S Siwar Soltani

Experiences of Patients With Atrial Fibrillation Using Technology to Personalize Self-Care Decision-Making: Interpretive Description Study

JMIR Cardio. 2026 Jun 11;10:e93036. doi: 10.2196/93036.ABSTRACTBACKGROUND: Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is a challenging chronic disease to manage. Patients' daily self-care decisions are associated with improved AF outcomes, quality of life, and de

K Kathy L Rush

Development of an mHealth Intervention for Reducing Sedentary Behavior in Older Adults: Delphi Study

J Med Internet Res. 2026 Jun 11;28:e83302. doi: 10.2196/83302.ABSTRACTBACKGROUND: Sedentary behavior among older adults is a major public health concern, contributing to the increased risk of chronic diseases and functional decline. With aging populations worldwide, prolonged sitting time (averaging

S Siqing Chen

Biological Variation of Natriuretic Peptides and Other Cardiovascular Disease-Related Biomarkers: A Systematic Review and Meta-analysis

Clin Chem. 2026 Jun 11:hvag051. doi: 10.1093/clinchem/hvag051. Online ahead of print.ABSTRACTBACKGROUND: The clinical application of cardiovascular disease (CVD) biomarkers requires robust biological variation (BV) data to enable both interpretation of serial results and definition of appropriate an

P Pilar Fernández-Calle

Identification of Pulmonary Arterial Hypertension Patients with Venous or Capillary Involvement

Am J Respir Crit Care Med. 2026 Jun 11:aamag289. doi: 10.1093/ajrccm/aamag289. Online ahead of print.ABSTRACTRATIONALE: While therapeutic advances have improved survival in Group 1 Pulmonary Arterial Hypertension (PAH), patients with Group 1.5 "PAH with features of venous/capillary involvement" (for

A Adam M Andruska

Recaticimab: The First Fc-Engineered PCSK9 Monoclonal Antibody for More Long-Lasting Effect in Lipid Lowering

Drugs. 2026 Jun 11. doi: 10.1007/s40265-026-02348-4. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) continues to be a leading cause of morbidity and mortality worldwide, with elevated low-density lipoprotein cholesterol (LDL-C) being a major modifiable risk factor. Desp

S Sha Li

AI-Guided Patient-Derived Endothelial Modeling Identifies a Reversible Moyamoya-Specific miRNA Deficiency Corrected by Stem Cell-Extracellular Vesicles

Transl Stroke Res. 2026 Jun 11;17(3):65. doi: 10.1007/s12975-026-01456-3.ABSTRACTMoyamoya disease (MMD) is a progressive cerebrovascular disorder characterized by abnormal vascular remodeling and impaired angiogenesis. We profiled plasma extracellular vesicle (EV)-derived microRNAs (miRNAs) from MMD

J Ji Hoon Bang

Prognostic impact of iliofemoral access-site calcification volume on outcomes after transcatheter aortic valve implantation

Clin Res Cardiol. 2026 Jun 11. doi: 10.1007/s00392-026-02956-w. Online ahead of print.ABSTRACTBACKGROUND: Transcatheter aortic valve implantation (TAVI) is increasingly performed in patients at low and intermediate risk, emphasizing the need for accurate long-term risk stratification. Although iliof

V Vivian Vij

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Dysfunction in Human Diseases: Molecular Mechanisms and Pathophysiological Implications

Cells. 2026 Jun 4;15(11):1034. doi: 10.3390/cells15111034.ABSTRACTCystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction is increasingly recognized as a key contributor to a broad spectrum of human diseases beyond classical cystic fibrosis (CF). CFTR is a cAMP-regulated chloride and

M Md Sohanur Rahman

Cardiovascular and Clinical Manifestations of Marfan Syndrome and Other Inherited Connective Tissue Disorders with Coexisting Genetic Variants

Cells. 2026 May 29;15(11):1001. doi: 10.3390/cells15111001.ABSTRACTMarfan syndrome (MS), Loeys-Dietz syndrome (LDS), Beals-Hecht syndrome (BHS), Ehlers-Danlos syndrome (EDS), and individuals with undifferentiated connective tissue disease (UCTD) exhibit phenotypic overlap, suggesting a likelihood of

M Maria Elena Soto

CRP (C-Reactive Protein) Revisited: An Old Yet New Biomarker of Acute and Chronic Inflammation

Cells. 2026 May 29;15(11):998. doi: 10.3390/cells15110998.ABSTRACTC-reactive protein (CRP) was discovered as a protein that reacts with C-polysaccharides to form precipitates in the serum of patients with pneumococcal infection. Subsequently, it was found to increase in the serum of patients with ba

M Masayuki Nagasawa

Vascular Aging and Atherosclerosis: The Modulatory Impact of Selenium-A Comprehensive Review

Cells. 2026 May 25;15(11):973. doi: 10.3390/cells15110973.ABSTRACTSelenium (Se), a vital trace element, plays a significant role in maintaining vascular health and may offer protective effects against atherosclerosis. Its actions are mediated through Se-dependent selenoenzymes and selenoproteins, wh

A Andrea Borghini

Deficiency of Inactive Rhomboid Protein 2 (iRhom2) Attenuates Macrophage Atherogenicity

Biology (Basel). 2026 May 30;15(11):860. doi: 10.3390/biology15110860.ABSTRACTInactive rhomboid protein 2 (iRhom2) regulates ADAM17-mediated shedding of tumor necrosis factor-α (TNF-α) from immune cells. We previously showed that iRhom2 deficiency attenuates early atherosclerosis in mice. This study

C Carmen Hannemann

A Phenome-Wide Comparative Analysis of Individualized Network Heterogeneity Across Treatment-Response Subphenotypes in Coronary Heart Disease

Biology (Basel). 2026 May 28;15(11):843. doi: 10.3390/biology15110843.ABSTRACTTo address the heterogeneity in treatment effects (HTE) in precision medicine for coronary heart disease (CHD), we employed an individualized network analysis framework (Pheno-NM) to elucidate the molecular mechanisms of H

S Shuang Guan

Research Progress on the Role of Traditional Chinese Medicine in Regulating Ferroptosis in Cardiovascular Diseases

Biology (Basel). 2026 May 23;15(11):824. doi: 10.3390/biology15110824.ABSTRACTFerroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation, playing a critical role in the pathogenesis of various cardiomyopathies, including hypertrophic, dilated, diabetic, ischemic, doxo

P Pan Li

Impact of Concomitant Mitral Regurgitation in Moderate Aortic Stenosis: Assessment of Remodeling and Clinical Outcomes

JACC Cardiovasc Imaging. 2026 Jun 10:S1936-878X(26)00259-7. doi: 10.1016/j.jcmg.2026.04.015. Online ahead of print.ABSTRACTBACKGROUND: Patients with moderate aortic stenosis (AS) and concomitant mitral regurgitation (MR) often present with symptoms despite neither lesion individually reaching interv

E El-Moatasem Gabr

Lymphatic dysfunction and ZFP36 deficiency contribute to myxomatous valve degeneration in Marfan Syndrome mice

J Clin Invest. 2026 Jun 2:e195507. doi: 10.1172/JCI195507. Online ahead of print.ABSTRACTEnhanced TGFβ signaling caused by mutations in Fibrillin-1 (FBN1) in patients with Marfan syndrome (MFS) leads to myxomatous degeneration of the mitral valve (MDMV). MDMV can result in mitral valve prolapse, sev

C Can Tan

Long-term Effect of C-Peptide Level on Clinical Outcomes in the Scottish Type 1 Bioresource Cohort

Diabetes Care. 2026 Jun 11:dc251738. doi: 10.2337/dc25-1738. Online ahead of print.ABSTRACTOBJECTIVE: To characterize associations of C-peptide measurements with type 1 diabetes (T1D) complications across long-term clinical follow-up in a large representative population cohort (Scottish Diabetes Res

J Joseph C Mellor

Achieving High Smoking Abstinence Rates After Myocardial Infarction: A Cardiology-Led Intervention Within Cardiac Rehabilitation

No abstractEur J Prev Cardiol. 2026 Jun 11:zwag318. doi: 10.1093/eurjpc/zwag318. Online ahead of print.NO ABSTRACTPMID:42274373 | DOI:10.1093/eurjpc/zwag318

V Víctor Marcos-Garcés