Gigascience. 2026 May 22:giag060. doi: 10.1093/gigascience/giag060. Online ahead of print.ABSTRACTMany research domains are producing large, multi-scale, multi-modal datasets at growing rates with mixed variable types (continuous, discrete, censored). Identifying possible cause-effect associations i
JAMA Netw Open. 2026 May 1;9(5):e2614030. doi: 10.1001/jamanetworkopen.2026.14030.ABSTRACTIMPORTANCE: Guideline-adherent management of pediatric in-hospital cardiac arrest (IHCA) remains challenging, and deviations from best practices are common. Augmented-reality (AR)-enabled, role-specific decisio
JAMA Netw Open. 2026 May 1;9(5):e2614046. doi: 10.1001/jamanetworkopen.2026.14046.ABSTRACTIMPORTANCE: Optimizing participant recruitment is critical to the success and generalizability of clinical research, yet there is limited randomized clinical trial evidence comparing the effects of digital recr
Oncol Ther. 2026 May 22. doi: 10.1007/s40487-026-00444-9. Online ahead of print.ABSTRACTINTRODUCTION: Cancer cells rewire their metabolism toward aerobic glycolysis (the Warburg effect), leading to lactate production that supports tumor growth, hypoxia adaptation, and immune evasion. In this context
Cardiol Ther. 2026 May 22. doi: 10.1007/s40119-026-00451-x. Online ahead of print.ABSTRACTThe inaugural 2025 Cardiometabolic Summit in Saclay, France, aimed to (i) disseminate the latest research on cardiometabolic diseases (CMDs) from the Maghreb and/or Middle East and North Africa region; (ii) dis
Egypt Heart J. 2026 May 22;78(1):38. doi: 10.1186/s43044-026-00752-5.ABSTRACTINTRODUCTION: Cardiac rehabilitation is a multidisciplinary intervention designed to improve functional capacity and quality of life in patients with cardiovascular diseases. However, its impact on anthropometric and functi
Cardiovasc Drugs Ther. 2026 May 22. doi: 10.1007/s10557-026-07890-7. Online ahead of print.ABSTRACTCardiorenal disease reflects a tightly interconnected pathophysiological continuum driven by neurohormonal activation, inflammation, oxidative stress, and progressive fibrosis. Among these mechanisms,
Mol Cell Biochem. 2026 May 22. doi: 10.1007/s11010-026-05541-x. Online ahead of print.ABSTRACTDoxorubicin (DOX)-induced cardiotoxicity is strongly associated with ferroptosis and oxidative stress, yet the endogenous protective mechanisms remain incompletely understood. This study aimed to determine
Geroscience. 2026 May 22. doi: 10.1007/s11357-026-02326-4. Online ahead of print.ABSTRACTWorkaholism, also referred to as problematic overworking, has received increasing attention due to its adverse consequences for individuals, families, and organizations. This perspective paper argues that workah
Neurochem Res. 2026 May 22;51(3):168. doi: 10.1007/s11064-026-04782-y.ABSTRACTIndividuals with hypertension carry a high risk of stroke, which endangers human health. The study systematically elucidated the dynamic expression, functional effects, and molecular mechanisms of the circular RNA LPAR3 in
Int J Clin Pharm. 2026 May 22. doi: 10.1007/s11096-026-02160-w. Online ahead of print.ABSTRACTINTRODUCTION: The preoperative use of dual antiplatelet therapy (DAPT) in patients undergoing carotid endarterectomy (CEA) is controversial.AIM: This study aimed to compare perioperative major bleeding and
Int J Clin Pharm. 2026 May 22. doi: 10.1007/s11096-026-02163-7. Online ahead of print.ABSTRACTINTRODUCTION: Patient characteristics and clinical factors could necessitate switching between oral anticoagulants (OACs) for stroke prevention in atrial fibrillation (AF), a phenomenon whose causes and con
Metab Brain Dis. 2026 May 22;41(1):111. doi: 10.1007/s11011-026-01871-3.ABSTRACTOBJECTIVE: To investigate the effects of electroacupuncture (EA) on post-ischemic angiogenesis and autophagy regulation after ischemic stroke, and to clarify the functional involvement of the ELAVL1/SIRT1/FOXO1 signaling
Neurochem Res. 2026 May 22;51(3):172. doi: 10.1007/s11064-026-04780-0.ABSTRACTExercise preconditioning reduces post-stroke cognitive impairment (PSCI), but the contribution of the gut microbiota (GM) to barrier protection remains unclear. We examined whether exercise-preconditioned GM contributes to
Mol Biol Rep. 2026 May 22;53(1):809. doi: 10.1007/s11033-026-12007-2.ABSTRACTCurcumin, a polyphenolic compound derived from Curcuma longa, and berberine, an isoquinoline alkaloid extracted from plants such as Coptis chinensis, exhibit multifaceted pharmacological properties, including potent antioxi
Biomech Model Mechanobiol. 2026 May 22;25(3):46. doi: 10.1007/s10237-026-02065-7.ABSTRACTHemodynamic analysis is an essential tool for predicting the behavior of blood flows and assessing the risk of renovascular diseases. In this paper, by employing a CFD-based finite element method coupled with an
J Neurol. 2026 May 22;273(6):327. doi: 10.1007/s00415-026-13871-5.ABSTRACTBACKGROUND: Access to timely post-acute stroke rehabilitation remains inconsistent, contributing to persistent disability despite advances in acute stroke care. Telemedicine has been proposed as a strategy to improve continuit
Neurosurg Rev. 2026 May 22;49(1):416. doi: 10.1007/s10143-026-04337-3.ABSTRACTChronic internal carotid artery occlusion (CICAO) is a significant cause of ischemic cerebrovascular events, with an annual stroke risk of up to 20%. Although the long-term efficacy of hybrid surgical revascularization (HS
Neurol Sci. 2026 May 22;47(6):513. doi: 10.1007/s10072-026-09104-2.ABSTRACTINTRODUCTION: Post-stroke epilepsy (PSE) is a common complication following a stroke and is a major cause of epilepsy in the elderly. Artificial intelligence (AI) is currently developing rapidly in the medical field and has a
Hernia. 2026 May 22;30(1):227. doi: 10.1007/s10029-026-03723-6.ABSTRACTPURPOSE: To review the renal consequences of complex abdominal wall reconstruction (AWR) and examine how reconstructive mechanics, intra-abdominal pressure, perioperative fluid strategy, and baseline renal reserve influence posto
Biomech Model Mechanobiol. 2026 May 22;25(3):48. doi: 10.1007/s10237-026-02079-1.ABSTRACTAbdominal aortic aneurysm (AAA) is often asymptomatic, making early detection challenging. As the aneurysm expands, it alters the hemodynamic forces exerted on the arterial wall, which in turn influence disease
J Neurol. 2026 May 22;273(6):331. doi: 10.1007/s00415-026-13875-1.ABSTRACTBACKGROUND: Accurate prognostication in deep supratentorial intracerebral hemorrhage (ICH) remains challenging. Hematoma volume is a key determinant of outcome and a component of the ICH Score. Whether radiomics-derived shape
Graefes Arch Clin Exp Ophthalmol. 2026 May 22. doi: 10.1007/s00417-026-07273-6. Online ahead of print.ABSTRACTSystemic vascular and neurodegenerative disorders are important causes of disability and death worldwide, mainly because of the late stage of diagnosis and the high cost of current screening
Acta Diabetol. 2026 May 22. doi: 10.1007/s00592-026-02707-3. Online ahead of print.ABSTRACTBACKGROUND: Diabetic cardiomyopathy (DCM) frequently begins with diastolic dysfunction (DD), which leads to increased left ventricular filling pressures and subsequent left atrial enlargement, quantified by th
