Alzheimers Dement. 2025 Dec;21 Suppl 2:e104478. doi: 10.1002/alz70856_104478.ABSTRACTBACKGROUND: Though previous research supports diffusion tensor imaging (DTI) as a biomarker for white matter integrity in diseases such as Alzheimer's disease/mild cognitive impairment (ADMCI), Parkinson's disease (
Am J Physiol Renal Physiol. 2025 Dec 26. doi: 10.1152/ajprenal.00194.2025. Online ahead of print.ABSTRACTNaCl restriction upregulates pendrin, in part, through increased circulating aldosterone and the intercalated cell (IC) mineralocorticoid receptor (MR). Since 11 HSD2 enhances aldosterone bindi
Clin Rheumatol. 2025 Dec 26. doi: 10.1007/s10067-025-07899-7. Online ahead of print.ABSTRACTBACKGROUND: Xanthine oxidase inhibitors (XOis) are commonly used to treat gout and hyperuricemia. Beyond urate-lowering effects, XOis may influence cardiovascular outcomes via oxidative stress pathways. Prior
Alzheimers Dement. 2025 Dec;21 Suppl 2:e103087. doi: 10.1002/alz70856_103087.ABSTRACTBACKGROUND: Latin America (LA) experiences disparities driven by social determinants of health and low socioeconomic status, which increase the risk of dementia. These adverse factors may contribute to dementia thro
Neurosurg Rev. 2025 Dec 26;49(1):89. doi: 10.1007/s10143-025-04024-9.ABSTRACTIntracerebral hemorrhage (ICH) significantly threatens human health, and educational attainment (EA) may influence the burden of ICH. We aim to explore the relationship between EA levels and ICH by Mendelian randomization (
Cell Mol Life Sci. 2025 Dec 26. doi: 10.1007/s00018-025-06026-8. Online ahead of print.ABSTRACTBACKGROUND: Atherosclerosis is a chronic vascular inflammatory disease caused by multiple factors. Anti-inflammatory treatment is an effective approach to treat atherosclerosis. Talin1 is a cell membrane-a
J Mol Med (Berl). 2025 Dec 26;104(1):15. doi: 10.1007/s00109-025-02623-z.ABSTRACTPhysical activity is widely accepted for its myriad health benefits, serving as protective mechanisms against many chronic diseases. At the molecular level, exercise exerts its beneficial effects partly through the rele
High Blood Press Cardiovasc Prev. 2025 Dec 26. doi: 10.1007/s40292-025-00777-y. Online ahead of print.ABSTRACTHyperuricemia is a metabolic disorder associated with an increased risk of gout, chronic kidney disease (CKD), and cardiovascular disease (CVD). The management of hyperuricemia in conditions
Alzheimers Dement. 2025 Dec;21 Suppl 2:e103352. doi: 10.1002/alz70856_103352.ABSTRACTBACKGROUND: Cerebrovascular disease (CeVD) is a clinically significant disease entity, known to be associated with increased risk of cognitive decline [1]. However, the lack of validated blood biomarkers for CeVD, l
J Endocrinol Invest. 2025 Dec 26. doi: 10.1007/s40618-025-02756-5. Online ahead of print.ABSTRACTPURPOSE: This study aimed to evaluate the one-year metabolic and renal effects of combined therapy with SGLT-2 inhibitors and GLP-1 receptor (GLP-1R) agonists in patients with type 2 diabetes mellitus (T
Curr Atheroscler Rep. 2025 Dec 26;28(1):4. doi: 10.1007/s11883-025-01379-8.ABSTRACTPURPOSE OF REVIEW: Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality despite optimal LDL-C control, leaving substantial residual risk in patients with atherogenic dyslipidaemia. This
J Mol Med (Berl). 2025 Dec 26;104(1):13. doi: 10.1007/s00109-025-02624-y.ABSTRACTVascular remodeling, which results in aortic sclerosis, is one of the main risk factors for hypertension-related cardiovascular events. In the process of early intervention and clinical improvement, the inhibition of th
Comput Assist Surg (Abingdon). 2026 Dec;31(1):2597553. doi: 10.1080/24699322.2025.2597553. Epub 2025 Dec 26.ABSTRACTReinforcement learning (RL) has emerged as a powerful artificial intelligence paradigm in medical image analysis, excelling in complex decision-making tasks. This systematic review syn
CONCLUSION: ^(18)F-SMBT-1 is a robust surrogate marker of regional reactive astrogliosis. It is highly correlated with Aβ burden and with plasma GFAP. High ^(18)F-SMBT-1 precedes and predicts high Aβ suggesting reactive astrogliosis is an interesting target for early therapeutic interventions.Alzhei
Alzheimers Dement. 2025 Dec;21 Suppl 3:e107780. doi: 10.1002/alz70857_107780.ABSTRACTBACKGROUND: Vascular Cognitive Impairment (VCI) is the second most common cause of dementia after Alzheimer's Disease (AD) (Gorelick et al.,2011). The coexistence of cerebrovascular pathology with AD pathology adds
Haemophilia. 2025 Dec 26. doi: 10.1111/hae.70187. Online ahead of print.ABSTRACTBACKGROUND: The clinical focus of haemophilia has expanded beyond bleeding outcomes to encompass long-term comorbidities such as cardiovascular disease (CVD). However, it remains unclear when vascular changes begin in th
Essays Biochem. 2025 Nov 26;69(3):195-197. doi: 10.1042/EBC20253053.ABSTRACTSeminal epidemiological studies led by Barker, Hales and collaborators identifying links between low birth weight and subsequent risk of traditionally adult-onset diseases such as cardiovascular disease and type 2 diabetes l
J Clin Hypertens (Greenwich). 2025 Dec;27(12):e70169. doi: 10.1111/jch.70169.ABSTRACTThis study aimed to elucidate the temporal trends and distribution characteristics of the cardiovascular disease (CVD) burden attributable to high sodium intake, while forecasting future shifts by 2030 in this disea
Aliment Pharmacol Ther. 2025 Dec 26. doi: 10.1111/apt.70500. Online ahead of print.ABSTRACTBACKGROUND: Steatotic liver disease (SLD) and cardiometabolic risk factors (CMRFs) are common in chronic hepatitis C (CHC). The risk of major adverse cardiovascular events (MACEs) after sustained virological r
Alzheimers Dement. 2025 Dec;21 Suppl 2:e104492. doi: 10.1002/alz70856_104492.ABSTRACTBACKGROUND: Impaired glymphatic clearance has been associated with neurodegenerative diseases causing dementia. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index has been proposed as
Clin Cardiol. 2025 Dec;48(12):e70245. doi: 10.1002/clc.70245.ABSTRACTBACKGROUND: Heart failure (HF) is still an important disease with high mortality rates worldwide. HF treatment is also difficult due to different phenotypes. Diuretic response (DR) is one of the main differences across these subgro
Wilderness Environ Med. 2025 Dec 26:10806032251409144. doi: 10.1177/10806032251409144. Online ahead of print.ABSTRACTIntroductionThe primary objective of this study was to assess cardiovascular risk among members of the Bulgarian Antarctic expedition and identify strategies for risk reduction. The c
Alzheimers Dement. 2025 Dec;21 Suppl 5:e107036. doi: 10.1002/alz70859_107036.ABSTRACTBACKGROUND: Oxidative stress (OS) plays a significant role in vascular mild cognitive impairment (vMCI), and the antioxidant N-acetylcysteine (NAC) was proposed to mitigate cognitive decline. However, our randomized
Aust J Rural Health. 2025 Dec;33(6):e70130. doi: 10.1111/ajr.70130.ABSTRACTINTRODUCTION: Cardiometabolic disease contributes to increased morbidity and mortality in rural and remote Australia. Digital health technologies offer a promising solution to enhance healthcare access and support self-manage
