Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing
Ann Neurol. 2026 Jun 17. doi: 10.1002/ana.78282. Online ahead of print.ABSTRACTOBJECTIVE: Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene-targeting strategies have thus far failed in clinical trials. Exercise remains the only inte

