Therapeutic potential of ADAR1-regulated macrophage exosomes for improving myocardial damage in septic cardiomyopathy

J Nanobiotechnology. 2026 Apr 11. doi: 10.1186/s12951-026-04368-4. Online ahead of print.ABSTRACTBACKGROUND: Sepsis-induced cardiomyopathy (SICM) is a critical cardiovascular complication characterized by cardiac dysfunction and high mortality. The molecular mechanisms that underlie SICM remain elus

L Linxiao Wang

Effectiveness of a multi-component intervention strategy on blood pressure control among older patients with hypertension: a target trial emulation

No abstractBMC Geriatr. 2026 Apr 11. doi: 10.1186/s12877-026-07452-4. Online ahead of print.NO ABSTRACTPMID:41965538 | DOI:10.1186/s12877-026-07452-4

B Bing Pei

Practical Recommendations for Cardiology Follow-Up in Patients Treated with Fenfluramine Based on Expert Opinion and Clinical Experience

Neurol Ther. 2026 Apr 11. doi: 10.1007/s40120-026-00930-2. Online ahead of print.ABSTRACTINTRODUCTION: Fenfluramine (FFA) is approved as an adjunctive treatment for epileptic seizures associated with Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS) in patients aged 2 years and older. Owing to

A Antonio Gil-Nagel

A time-series analysis of the short-term effects of daily PM2.5 exposure on cause-specific mortality in Mashhad, Iran (2019-2024)

Fine particulate matter (PM(2.5)) is a major environmental risk factor associated with increased mortality from cardiovascular and respiratory diseases worldwide. This study examined the short-term association between daily PM(2.5) exposure and cause-specific mortality in Mashhad, a large metropolit

M Majid Kermani

Acteoside attenuates myocardial ischemia reperfusion injury by inhibiting the NLRP3 inflammasome activity via the PI3K/Akt signaling pathway

No abstractSci Rep. 2026 Apr 11. doi: 10.1038/s41598-026-47002-x. Online ahead of print.NO ABSTRACTPMID:41965388 | DOI:10.1038/s41598-026-47002-x

L Linlin Jia

Yixinyuan Gaofang ameliorates myocardial infarction in rats by inhibiting the TNF/NF-κB pathway

Sci Rep. 2026 Apr 11. doi: 10.1038/s41598-026-46845-8. Online ahead of print.ABSTRACTMyocardial infarction (MI) is a severe cardiovascular disease with complex pathogenesis, in which inflammatory responses and oxidative stress play critical roles. Yixinyuan Gaofang (YXYGF) is a novel traditional Chi

L Lan Xiao

β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction

Nat Commun. 2026 Apr 11. doi: 10.1038/s41467-026-71612-8. Online ahead of print.ABSTRACTNeutrophils rapidly accumulate in the heart after myocardial infarction (MI), yet bone marrow granulopoiesis peaks later, suggesting an alternative early source. Here we show in male mice that the first wave of n

A Albert Dahdah

PDK4 drives abdominal aortic aneurysm by promoting smooth muscle cell metabolic reprogramming and NLRP3-mediated pyroptosis

Nat Commun. 2026 Apr 11. doi: 10.1038/s41467-026-71610-w. Online ahead of print.ABSTRACTAbdominal aortic aneurysm (AAA) is a progressive dilation of the abdominal aorta that can rupture and cause catastrophic internal bleeding, yet the mechanisms driving AAA remain poorly understood. Here we show th

L Li Zhao

Clinical and cost-effectiveness of SPACE for COPD delivered as a pulmonary rehabilitation maintenance programme: a randomised controlled trial

Thorax. 2026 Apr 11:thorax-2025-223734. doi: 10.1136/thorax-2025-223734. Online ahead of print.ABSTRACTINTRODUCTION: The benefits of pulmonary rehabilitation (PR) decline after 6-12 months. Previous studies of maintenance in the literature have been labour-intensive and concentrated on secondary car

L Linzy Houchen-Wolloff

Current and emerging approaches to managing peripheral artery disease: a specialist review

Heart. 2026 Apr 11:heartjnl-2025-326532. doi: 10.1136/heartjnl-2025-326532. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) affects over 113 million people worldwide and is a marker of systemic atherosclerosis associated with significant cardiovascular and limb morbidity. While classic

A Abbas Mohammadi

Treatment-modifying effects of frailty on stroke reperfusion therapy outcomes: a systematic review and meta-analysis

Age Ageing. 2026 Apr 4;55(4):afag080. doi: 10.1093/ageing/afag080.ABSTRACTBACKGROUND: Frailty is common amongst individuals presenting with acute ischaemic stroke (AIS). Not only has frailty been found to have disease-modifying effects in terms of survival and disability after AIS, but it may also e

A Anakha Varma

Consistent benefit of physiology-guided complete revascularization across the spectrum of frailty in older patients with myocardial infarction: a prespecified analysis of the FIRE trial

Age Ageing. 2026 Apr 4;55(4):afag078. doi: 10.1093/ageing/afag078.ABSTRACTBACKGROUND: The number of older patients admitted with myocardial infarction (MI) is increasing, and their clinical profiles range from very fit to frail and functionally impaired.OBJECTIVES: To evaluate whether the benefits o

B Beatrice Dal Passo

Arterial Stiffness Mechanisms and Orthostatic Hypotension in SPRINT: A Randomized Controlled Trial

JACC Adv. 2026 Apr 10;5(5):102734. doi: 10.1016/j.jacadv.2026.102734. Online ahead of print.ABSTRACTBACKGROUND: Hypertension is a leading cardiovascular disease risk factor. Intensive blood pressure (BP) control reduces cardiovascular disease events but may be limited by treatment-related serious ad

R Ryan Pewowaruk

Accelerometer-Measured Sedentary Behavior, Future Disease, and Cardiovascular-Kidney-Metabolic Health

JACC Adv. 2026 Apr 9;5(5):102718. doi: 10.1016/j.jacadv.2026.102718. Online ahead of print.ABSTRACTBACKGROUND: Effects of sedentary behavior across the spectrum of future disease, including cardiovascular-kidney-metabolic (CKM) syndrome-related conditions, are poorly understood.OBJECTIVES: The objec

E Ezimamaka Ajufo

Association of physical function with cardiovascular risk in middle-aged and older patients with schizophrenia

J Psychosom Res. 2026 Apr 8;207:112661. doi: 10.1016/j.jpsychores.2026.112661. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular disease is a leading cause of mortality among patients with schizophrenia. Impaired physical function may contribute to the elevated cardiovascular risk in this pop

M Mingqi Wang

The status of depression associated with macrovascular and microvascular comorbidities in patients with long-duration type 2 diabetes: A cross-sectional study from the Taiwan diabetes registry

J Psychosom Res. 2026 Apr 7;207:112662. doi: 10.1016/j.jpsychores.2026.112662. Online ahead of print.ABSTRACTBACKGROUND: Psychologic distress, including depression, is a common problem in patients with type 2 diabetes mellitus (T2DM). However, how depression severity relates to vascular complication

C Chun-Yung Chang

In perspective: ST-Elevation Myocardial Infarction Door to Unload (STEMI-DTU) trial

No abstractEur Heart J Acute Cardiovasc Care. 2026 Apr 8:zuag055. doi: 10.1093/ehjacc/zuag055. Online ahead of print.NO ABSTRACTPMID:41965101 | DOI:10.1093/ehjacc/zuag055

F Frederik H Verbrugge

Oncovirus-Driven Endothelial Plasticity: Endothelial-to-Mesenchymal Transition as a Hijacked Pathway in Oncoviral Cardiovascular Pathogenesis

Rev Med Virol. 2026 May;36(3):e70143. doi: 10.1002/rmv.70143.ABSTRACTOncoviruses utilise various molecular strategies to modulate host cells and induce microenvironments that favour viral persistence, immune evasion, and disease progression. Endothelial-to-mesenchymal transition (EndMT) has recently

M Ming Li

Predictive Value of the Triglyceride-Glucose Index for Metabolic Syndrome in Adults from Southeastern Mexico

Metab Syndr Relat Disord. 2026 May;24(4):172-177. doi: 10.1177/15578518261416761. Epub 2026 Apr 11.ABSTRACTBACKGROUND: The clinical significance of metabolic syndrome (MetS) stems from its strong association with the incidence and mortality of cardiovascular disease (CVD) and type 2 diabetes (T2D),

A Azalia Avila-Nava

Natural Course of Untreated Obstructive Sleep Apnea in Adults with Coronary Artery Disease in the RICCADSA Cohort

Ann Am Thorac Soc. 2026 Apr 8:aaoag072. doi: 10.1093/annalsats/aaoag072. Online ahead of print.ABSTRACTRATIONALE: Recent randomized controlled trials failed to show cardiovascular benefits of treating obstructive sleep apnea (OSA) in intention-to-treat analyses which has been a matter of debate sinc

Y Yüksel Peker

Neonatal Case of Fetal Pleural Effusion Caused by Cor Triatriatum Dexter with Postnatal Worsening of Superior Vena Cava Syndrome

No abstractPediatr Cardiol. 2026 Apr 11. doi: 10.1007/s00246-026-04257-5. Online ahead of print.NO ABSTRACTPMID:41964870 | DOI:10.1007/s00246-026-04257-5

H Hitomi Kimura

Genome-wide association study and pathway analysis of healthy aging in Super Seniors

Geroscience. 2026 Apr 11. doi: 10.1007/s11357-026-02229-4. Online ahead of print.ABSTRACTHealthy aging is a complex process influenced by genetic, environmental, and lifestyle factors. Although prior genetic studies have identified loci associated with longevity, replication has often been limited b

R Rawnak Hoque

Post-Operative Safety Outcomes and 5-Year Healthcare Utilisation After Bariatric Surgery vs. Other Elective Types of Surgical Treatments - A Retrospective Observational Cohort Study

No abstractObes Surg. 2026 Apr 11. doi: 10.1007/s11695-026-08584-7. Online ahead of print.NO ABSTRACTPMID:41964779 | DOI:10.1007/s11695-026-08584-7

G Ghassan Chamseddine

Safety and efficacy of anticoagulation for cerebral amyloid angiopathy patients with high-risk atrial fibrillation

J Neurol. 2026 Apr 11;273(5):268. doi: 10.1007/s00415-026-13798-x.ABSTRACTBACKGROUND: Cerebral amyloid angiopathy (CAA) significantly increases intracranial hemorrhage (ICH) risk and the safety of anticoagulation (AC) among CAA patients with atrial fibrillation (AF) is uncertain.METHODS: This was a

H Huanwen Chen