Neuroprotective efficacy of Curcumae Rhizoma against ischemic stroke via attenuation of COX-2-mediated neuroinflammation: a systematic study predicting thrombin inhibition and highlighting alexandrin and hederagenin

Metab Brain Dis. 2026 Jun 16;41(1):135. doi: 10.1007/s11011-026-01901-0.ABSTRACTIschemic stroke is a major cause of mortality globally, but single-target therapies often fail due to the complex "ischemic cascade". This study investigated the neuroprotective effects and multitarget mechanisms of Curc

C Chiyeon Lim

National utilization of minimally invasive and open liver resections

Surg Endosc. 2026 Apr 20. doi: 10.1007/s00464-026-12678-9. Online ahead of print.ABSTRACTINTRODUCTION: Although minimally invasive (MIS) liver resections are associated with improved outcomes, uptake remains slow.METHODS: Using data from the Healthcare Cost and Utilization Project (HCUP) National In

V Vikram S Pothuri

Congenital Heart Disease in a Paralympic Athlete With Klinefelter Syndrome

JACC Case Rep. 2026 Jun 3:108748. doi: 10.1016/j.jaccas.2026.108748. Online ahead of print.ABSTRACTBACKGROUND: Sinus venosus atrial septal defects with partial anomalous pulmonary venous return (PAPVR) are rare congenital abnormalities.CASE SUMMARY: A 26-year-old competitive swimmer with Klinefelter

F Francisco B Alexandrino

Rsk4 Mediates Brain FGF19 Signaling to Constrain Diet-Induced Obesity in Mice

Diabetes. 2026 Jun 16:db250859. doi: 10.2337/db25-0859. Online ahead of print.ABSTRACTRibosomal S6 kinase 4 (Rsk4) is predominantly expressed in hypothalamic neurons. Rsk4 is negligible for maintaining energy homeostasis in mice. Loss of Rsk4 promotes diet-induced obesity and related metabolic disor

C Chaonan Li