The depletion of serine beta-lactamase-like protein (LACTB) ameliorates metabolic dysfunction-associated steatotic liver disease by reducing ubiquitin-mediated degradation of carnitine palmitoyltransferase 2

Diabetes Obes Metab. 2026 Jan 13. doi: 10.1111/dom.70483. Online ahead of print.ABSTRACTAIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) represents one of the most common chronic liver disorders worldwide, and its incidence continues to rise each year. Serine β-lactamase-like p

W Wujiang Shi

Loss of Mtarc1 Protects Against Steatotic Liver Disease in Mice

Liver Int. 2026 Feb;46(2):e70507. doi: 10.1111/liv.70507.ABSTRACTBACKGROUND & AIMS: Metabolic dysfunction-associated steatotic liver disease (MASLD) spans from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and can progress to cirrhosis or hepatocellular carcinoma. Despi

X Xiaofei Yin

LCZ696 (sacubitril/valsartan mixture) promotes cardiac repair and reverses residual remodelling of surgical ventricular reconstruction in post-myocardial infarction mice by targeting circMap4k2/LIN28A/PDK1 pathway

Br J Pharmacol. 2026 Jan 12. doi: 10.1111/bph.70320. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: LCZ696 (sacubitril/valsartan) can attenuate early cardiac remodelling of heart failure (HF), although it is less effective in severe remodelling. Surgical ventricular reconstruction (SVR) is us

J Junyu Yan

Comparison of the predictive performance of systemic immune-inflammation index and neutrophil-to-lymphocyte ratio for three-month poor functional outcome in ischemic stroke: a systematic review and meta-analysis

Ann Med. 2026 Dec;58(1):2612820. doi: 10.1080/07853890.2026.2612820. Epub 2026 Jan 12.ABSTRACTINTRODUCTION: Ischemic stroke (IS) is a leading cause of global mortality and disability. Early and accurate prognosis is crucial for patient management. The neutrophil-to-lymphocyte ratio (NLR) and systemi

X Xuan Ma

Quality of Life Assessment in the Management of Venous Leg Ulcers

Wound Repair Regen. 2026 Jan-Feb;34(1):e70124. doi: 10.1111/wrr.70124.ABSTRACTChronic venous insufficiency and venous leg ulcers remain a major challenge in wound care, with profound effects on patient health and quality of life. This prospective observational study compared clinical outcomes and pa

A Alvaro J Bernal Martinez

MASLD coexisting with PCOS increases cardiometabolic risk

J Clin Endocrinol Metab. 2026 Jan 13:dgag008. doi: 10.1210/clinem/dgag008. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: In women in their reproductive years, metabolic dysfunction-associated steatotic liver disease (MASLD) and polycystic ovary syndrome (PCOS) are the most common chronic liver

O Oyekoya T Ayonrinde

Developing an Evidence-Based and Patient-Centred Care Concept to Address Deficits in German Primary Care of Venous Leg Ulcers: Results of an Expert Survey Within the ULCUS CRURIS CARE Project

Int Wound J. 2026 Jan;23(1):e70829. doi: 10.1111/iwj.70829.ABSTRACTVenous leg ulcers (VLU) account for the majority of chronic wounds, with an estimated rise in prevalence due to demographic change. Care often does not comply with evidence, and patients remain passive and uninformed. To support gene

T Thomas Fleischhauer