Epigenetic control of metabolic identity across cell types

BMC Genomics. 2025 Dec 10. doi: 10.1186/s12864-025-12155-y. Online ahead of print.ABSTRACTBACKGROUND: Constraint-based network modeling is a powerful genomic-scale approach for analyzing cellular metabolism, capturing metabolic variations across tissues and cell types, and defining the metabolic ide

M Maria Pires Pacheco

Diagnostic significance of cardiac bridging integrator 1 score in hospitalized patients with heart failure with preserved ejection fraction and its assessment of prognostic value for major adverse cardiac events

BMC Cardiovasc Disord. 2025 Dec 10. doi: 10.1186/s12872-025-05399-9. Online ahead of print.ABSTRACTBACKGROUND: Cardiac bridging integrator 1 (cBIN1) is a cardiomyocyte-specific protein critical for excitation-contraction coupling. The cBIN1 score (CS), derived from plasma cBIN1 levels, serves as a n

X Xia Guo

Calciprotein crystallization time (T(50)) and its association with surrogate cardiovascular disease risk markers in individuals with type 2 diabetes mellitus: the cross-sectional EARLY-HFpEF study

CONCLUSION: Low T(50) was associated with increased risks of coronary arterial calcification and PAD (measured by ABI ≤ 0.9) in individuals with T2DM, but not with HFpEF, central arterial stiffness and lower-extremity arterial calcification. Further research is warranted to evaluate the additive val

R R Meer

Sex differences in inflammatory biomarkers during long-term evolocumab therapy

J Clin Lipidol. 2025 Nov 12:S1933-2874(25)00517-3. doi: 10.1016/j.jacl.2025.11.011. Online ahead of print.ABSTRACTBACKGROUND: Atherosclerotic cardiovascular disease remains a predominant cause of morbidity and mortality worldwide, driven by complex interactions between lipid metabolism and chronic i

F Federica Fogacci

Association of drinking water salinity with elevated blood pressure and risk of hypertension among coastal and other populations: a systematic review and meta-analysis of observational studies

BMJ Glob Health. 2025 Dec 10;10(12):e018543. doi: 10.1136/bmjgh-2024-018543.ABSTRACTBACKGROUND: The link between drinking water salinity and increased blood pressure and hypertension risk among coastal and other populations remains unclear. To investigate this, we performed a systematic review and m

R Rajat Das Gupta

Costs and cost-effectiveness of community health worker programmes focussed on non-communicable diseases in low- and middle-income countries (2015-2024): a scoping literature review

BMJ Glob Health. 2025 Dec 10;10(12):e018035. doi: 10.1136/bmjgh-2024-018035.ABSTRACTBACKGROUND: Non-communicable diseases (NCDs) are the leading cause of death and morbidity worldwide, responsible for 7 out of 10 deaths, 86% occurring in low- and middle-income countries (LMICs). As the NCD burden on

J James O'Donovan

The Emerging Lipid Risk: Lipoprotein(a)

Korean Circ J. 2025 Oct 20. doi: 10.4070/kcj.2025.0380. Online ahead of print.ABSTRACTBased on epidemiological and genetic studies in recent decades, lipoprotein(a) (Lp(a)) has been accepted as a causal risk factor for atherosclerotic cardiovascular disease and aortic stenosis. Although inter-ethnic

S Sang-Hak Lee