CNS Neurosci Ther. 2025 Dec;31(12):e70715. doi: 10.1002/cns.70715.ABSTRACTBACKGROUND: Abnormally high shear stress (HSS) is strongly associated with intracranial aneurysm (IA) formation. Endothelial Piezo1 is sensitive to shear stress stimulation, but the mechanism by which it mediates this mechanob
Cardiooncology. 2025 Dec 29. doi: 10.1186/s40959-025-00434-2. Online ahead of print.ABSTRACTBACKGROUND: Breast cancer is the most common malignancy among women globally and the second most frequently diagnosed cancer overall, with 2.3 million new cases reported in 2022. While advances in therapy hav
BMC Geriatr. 2025 Dec 28. doi: 10.1186/s12877-025-06888-4. Online ahead of print.ABSTRACTBACKGROUND: In older adults with atrial fibrillation (AF), the presence of comorbid chronic kidney disease (CKD) may be more challenging for optimal disease management, influence stroke prophylaxis with oral ant
BMC Womens Health. 2025 Dec 29. doi: 10.1186/s12905-025-04236-7. Online ahead of print.ABSTRACTBACKGROUND: Gender disparities persist in health research, care and outcomes. The aim of this study was to identify and explore the health conditions and social issues that affect women and girls in Austra
Mol Biomed. 2025 Dec 29;6(1):151. doi: 10.1186/s43556-025-00397-x.ABSTRACTCardiac fibrosis following myocardial infarction (MI) is a pivotal driver of ventricular dysfunction and heart failure, yet the molecular checkpoints orchestrating the persistent activation of cardiac fibroblasts remain incomp
Curr Hypertens Rep. 2025 Dec 29;28(1):4. doi: 10.1007/s11906-025-01354-3.ABSTRACTPURPOSE: Chemerin, a recently identified adipokine, has emerged as a critical mediator in multiple physiological systems with significant implications for human health and disease. This review synthesizes current knowle
J Egypt Natl Canc Inst. 2025 Dec 29;37(1):80. doi: 10.1186/s43046-025-00336-5.ABSTRACTMultiple myeloma (MM) remains an incurable plasma cell malignancy despite advances with proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies. Bispecific antibodies (BsAbs) have emerged as a tran
Curr Cardiol Rep. 2025 Dec 29;28(1):5. doi: 10.1007/s11886-025-02331-7.ABSTRACTPURPOSE OF REVIEW: Leadless pacemakers (LPMs) are an established alternative to transvenous pacing systems for the treatment of bradyarrhythmias. This review outlines the evolution of LPMs, summarizes available safety and
Brain Inform. 2025 Dec 28. doi: 10.1186/s40708-025-00284-9. Online ahead of print.ABSTRACTBACKGROUND/OBJECTIVE: Predicting neurological outcomes in comatose cardiac arrest survivors remains challenging. Diffusion tensor imaging (DTI) offers potential as an objective biomarker of white matter injury,
Neurol Sci. 2025 Dec 29;47(1):60. doi: 10.1007/s10072-025-08688-5.ABSTRACTBACKGROUND: Most of the function-focused interventions performed on hemiparetic individuals consist of motor training.OBJECTIVES: The aim of this study was to examined the effects of sensory training applied to the lower extre
NPJ Digit Med. 2025 Dec 28. doi: 10.1038/s41746-025-02163-3. Online ahead of print.ABSTRACTLate gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging is a crucial modality for identifying myocardial scar, yet current binary segmentation approaches often fail to capture the continuous and
Sci Rep. 2025 Dec 28. doi: 10.1038/s41598-025-33005-7. Online ahead of print.ABSTRACTCardiovascular disease (CVD) remains the leading cause of global morbidity and mortality, with substantial economic implications for healthcare systems. Among hospitalized CVD patients, procedures such as angioplast
Mol Genet Genomic Med. 2026 Jan;14(1):e70171. doi: 10.1002/mgg3.70171.ABSTRACTBACKGROUND: Klinefelter Syndrome (KS) and Turner Syndrome (TS) are the two most common sex chromosome aneuploidies (SCAs). This study aims to investigate genotype-phenotype correlations of SCAs including classic, rare vari
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2026 Jan;40(1):28-33. doi: 10.13201/j.issn.2096-7993.2026.01.005.ABSTRACTObjective:To identify risk factors for retinopathy in patients with obstructive sleep apnea（OSA） and hypertension, and develop a machine learning-based risk prediction model by i
Eur J Intern Med. 2025 Dec 27:106682. doi: 10.1016/j.ejim.2025.106682. Online ahead of print.ABSTRACTBACKGROUND: Infective endocarditis (IE) is a serious and under-recognized complication of coagulase-negative staphylococci (CoNS) bacteraemia. The aim was to identify predictors of IE in patients wit
CNS Neurosci Ther. 2025 Dec;31(12):e70712. doi: 10.1002/cns.70712.ABSTRACTBACKGROUND: Atherosclerosis is a chronic inflammatory disorder and a major cause of ischemic stroke. Immune-mediated mechanisms are increasingly recognized as central in this continuum, yet the global research landscape and it
Aging Cell. 2026 Jan;25(1):e70332. doi: 10.1111/acel.70332.ABSTRACTTelomerase RNA (TERC) is subject to various modifications, yet the implications of these modifications for telomerase biology remain largely unexplored. In this study, we conducted a comprehensive mapping of N6-Methyladenosine (m6A)
CNS Neurosci Ther. 2025 Dec;31(12):e70718. doi: 10.1002/cns.70718.ABSTRACTBACKGROUND: Previous studies have indicated the potential benefits of tirofiban in preventing early neurological deterioration (END) in acute ischemic stroke (AIS) within 24 h of symptom onset. However, its efficacy and safety
Clin Respir J. 2025 Dec;19(12):e70147. doi: 10.1111/crj.70147.ABSTRACTINTRODUCTION: The objective of this study was to examine the development of chronic thromboembolic pulmonary disease (CTEPD) incidence, risk factors, and coexisting medical conditions following an episode of acute pulmonary emboli
Ann Noninvasive Electrocardiol. 2026 Jan;31(1):e70146. doi: 10.1111/anec.70146.ABSTRACTBACKGROUND: Population-based evidence on the predictive role of left ventricular ejection fraction (LVEF) in incident Cardiac Conduction Dysfunction (CCD) and the mediating effects of electrophysiological paramete
Can J Diabetes. 2025 Nov;49 Suppl 2:27-36.e4. doi: 10.1016/j.jcjd.2025.10.172.ABSTRACTOBJECTIVES: Our aim in this work was to 1) explore barriers and enablers to patient and health-care provider (HCP) behaviours related to sick-day medication guidance (SDMG), 2) identify theory-informed strategies t
Zhonghua Fu Chan Ke Za Zhi. 2025 Dec 25;60(12):943-950. doi: 10.3760/cma.j.cn112141-20250415-00149.ABSTRACTObjective: To evaluate the efficacy and safety of low-dose mifepristone (10-25 mg) in patients with thromboembolic disorders complicated by heavy menstrual bleeding (HMB). Methods: The data of
Zhonghua Yi Xue Za Zhi. 2025 Dec 30;105(48):4441-4452. doi: 10.3760/cma.j.cn112137-20250624-01538.ABSTRACTvon Hippel-Lindau (VHL) syndrome is an autosomal dominant hereditary disorder caused by germline heterozygous pathogenic variants of the VHL gene or promoter hypermethylation. It is characterize
Anal Biochem. 2025 Dec 26:116037. doi: 10.1016/j.ab.2025.116037. Online ahead of print.ABSTRACTBACKGROUND: Neutrophil extracellular traps (NETs) could help prevent and treat thrombosis-related diseases. Detecting NETs primarily relies on plasma; however, the impact of anticoagulants and plasma centr
