ITACARE-P

Association between preoperative vasoactive inotropic score and clinical outcomes in severe pneumonia patients with sepsis undergoing extracorporeal membrane oxygenation: an analysis from the Chinese Society of ExtraCorporeal Life Support (CSECLS) Registry

Eur J Med Res. 2026 Jan 31. doi: 10.1186/s40001-026-03932-w. Online ahead of print.ABSTRACTBACKGROUND: Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients with severe respiratory and/or cardiac failure. In patients with severe pneumonia, severe septic shock led to t

Wan Chen

Cardiovascular-kidney-metabolic syndrome: candidate subtypes and genetic risk factors

BMC Med Genomics. 2026 Jan 31. doi: 10.1186/s12920-026-02315-8. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome is increasingly recognized as a distinct disorder with important implications for health outcomes, but its heterogeneity of presentation and geneti

Hylke C Donker

Demographic, clinical, and immunological features in combined immunodeficiency patients: a comparative analysis of those with and without pulmonary manifestations - a multicenter study from Iran

BMC Pulm Med. 2026 Jan 31. doi: 10.1186/s12890-026-04115-3. Online ahead of print.ABSTRACTBACKGROUND: Combined immunodeficiency (CID) involves profound defects in B and T lymphocyte development and function. This study examined clinical and immunological phenotypes of CID patients with and without p

Ghamartaj Khanbabaee

Prevalence of diabetes/prediabetes and their associated risk factors among adults with hypertension from iran: a nationwide study

Sci Rep. 2026 Jan 31. doi: 10.1038/s41598-026-35998-1. Online ahead of print.ABSTRACTThe risk of cardiovascular diseases (CVDs) is significantly increased when diabetes mellitus and hypertension coexist. Improving the clinical management of people with hypertension requires understanding the prevale

Mina Mirzad

Plasma proteome mediates the associations between air pollution exposure and disease risk

Nat Commun. 2026 Jan 31. doi: 10.1038/s41467-026-68972-6. Online ahead of print.ABSTRACTAir pollution has been increasingly linked to a wide range of diseases, yet the underlying biological mechanisms remain poorly understood. Here, we systematically investigate how circulating proteins mediate the

Wenran Li

Intracerebral age-independent reduction of endothelium-dependent hyperpolarization and nitric oxide signalling in the Dp16 mouse model of Down syndrome

J Physiol. 2026 Jan 31. doi: 10.1113/JP290174. Online ahead of print.ABSTRACTDown syndrome (DS) is associated with a myriad of cardiovascular defects. Endothelial cells, which form the innermost layer of blood vessels, have been found to exhibit divergent morphology and functional impairments in the

Abigail N Russell

Mid-term clinical outcomes of FFRangio guided treatment for coronary artery disease: Insights from an international multicentre registry

Cardiovasc Revasc Med. 2026 Jan 23:S1553-8389(26)00013-8. doi: 10.1016/j.carrev.2026.01.012. Online ahead of print.ABSTRACTBACKGROUND: Wire-based fractional flow reserve (wbFFR) is the gold standard for physiologic assessment of coronary artery disease (CAD). Recently, angiogram-based FFRangio have

Guy Witberg

Reasoning-driven large language models in medicine: opportunities, challenges, and the road ahead

Lancet Digit Health. 2026 Jan 30:100931. doi: 10.1016/j.landig.2025.100931. Online ahead of print.ABSTRACTDevelopments in large language models (LLMs) in the past 2 years have shifted the focus from text, image, and audio generation to LLMs capable of multistep reasoning (thinking). The development

Xiaofei Wang

Mechano responsiveness of neuroimmune cross-talk in bone and joints: A narrative review with implications for force-based manipulations

Musculoskelet Sci Pract. 2026 Dec 31:103470. doi: 10.1016/j.msksp.2025.103470. Online ahead of print.ABSTRACTINTRODUCTION: Recent advances in osteoimmunology have illuminated the significant role of neuroimmune interactions in bone and joint health. The neuroimmune system critically regulates bone c

Karl J Lewis

Disproportionate atherosclerotic burden in the left anterior descending coronary artery in participants without standard modifiable cardiovascular risk factors: The multi-ethnic study of atherosclerosis (MESA)

J Cardiovasc Comput Tomogr. 2026 Jan 30:S1934-5925(26)00010-9. doi: 10.1016/j.jcct.2026.01.004. Online ahead of print.ABSTRACTBACKGROUND: Standard modifiable cardiovascular risk factors (SMuRF) have been identified for coronary artery disease (CAD) and targeted in primary prevention efforts, resulti

Michael P Gray

Sarcopenia as a causal mediator in aging, obesity and central obesity related outcomes: A comprehensive analysis of NHANES, CHARLS and ELSA

Nutr Metab Cardiovasc Dis. 2026 Jan 2:104541. doi: 10.1016/j.numecd.2026.104541. Online ahead of print.ABSTRACTBACKGROUND AND AIM: Sarcopenia, characterized by decreased muscle mass or muscle dysfunction, is associated with cardiovascular disease and mortality. However, the mediating effect of sarco

Sitong Li

The joint effect of cardiometabolic index and high-sensitivity C-reactive protein on incident cardiovascular disease: A prospective cohort study

Nutr Metab Cardiovasc Dis. 2026 Jan 14:104566. doi: 10.1016/j.numecd.2026.104566. Online ahead of print.ABSTRACTBACKGROUND AND AIM: The combined role of the cardiometabolic index (CMI), a marker of visceral obesity and dyslipidemia, and high-sensitivity C-reactive protein (hsCRP), an inflammatory ma

Jin-Hong Zhou

Prediction of mortality, bleeding, and ischaemic events in patients with cancer and acute coronary syndrome: a model development and validation study

Lancet. 2026 Jan 31;407(10527):515-528. doi: 10.1016/S0140-6736(25)02020-3.ABSTRACTBACKGROUND: Accurate assessment of mortality, bleeding, and atherothrombotic risk in patients with cancer and acute coronary syndrome could inform novel personalised treatment strategies, but no standardised tools for

Florian A Wenzl

Targeting FoxO1 in Cardiovascular Diseases: Mechanisms and Therapeutic Potential

Pharmacol Res. 2026 Jan 29:108122. doi: 10.1016/j.phrs.2026.108122. Online ahead of print.ABSTRACTCardiovascular Disease (CVDs), as a major life-threatening disease, has attracted worldwide attention. Seeking novel and effective therapeutic strategies is still among the important in the cardiovascul

Xue Wu

The Current Status of Cardiac Rehabilitation in China: A Cross-sectional National Survey

Arch Phys Med Rehabil. 2026 Jan 29:S0003-9993(26)00046-8. doi: 10.1016/j.apmr.2026.01.020. Online ahead of print.ABSTRACTOBJECTIVE: To investigate the current status of Cardiac rehabilitation (CR) in China by assessing its national availability, program characteristics, and key barriers to implement

Shu-Min Zhang

Multicenter Prospective Cohort Study on Clinical Outcomes and Fibrosis Patterns in Biopsy-Proven Steatotic Liver Disease Subtypes

Gastroenterology. 2026 Jan 29:S0016-5085(26)00030-2. doi: 10.1053/j.gastro.2026.01.007. Online ahead of print.ABSTRACTBACKGROUND & AIMS: Clinical outcomes and histological characteristics of biopsy-proven steatotic liver disease (SLD) subtypes remain understudied. We investigated clinical outcomes a

Gi-Ae Kim

Stress T1 mapping for the detection of obstructive coronary artery disease: a prospective diagnostic accuracy study

J Cardiovasc Magn Reson. 2026 Jan 29:102701. doi: 10.1016/j.jocmr.2026.102701. Online ahead of print.ABSTRACTBACKGROUND: In the assessment of patients with suspected coronary artery disease (CAD), the diagnostic role of stress-perfusion cardiovascular magnetic resonance (CMR) is well established. Ho

Simran Shergill

Associations between methylglyoxal and cerebral small vessel disease and cognitive function - The Maastricht Study

J Stroke Cerebrovasc Dis. 2026 Jan 29:108578. doi: 10.1016/j.jstrokecerebrovasdis.2026.108578. Online ahead of print.ABSTRACTBACKGROUND: Cerebral small vessel disease (CSVD) and dementia are increasingly prevalent in the aging population. Diabetes is a major risk factor for CSVD and cognitive impair

Eline Berends

Longitudinal study of arterial stiffness in pediatric patients with Type 1 Diabetes Mellitus (T1DM). Correlations with glycemic metrics derived from Continuous Glucose Monitoring (CGM) devices

Diabetes Res Clin Pract. 2026 Jan 29:113132. doi: 10.1016/j.diabres.2026.113132. Online ahead of print.ABSTRACTAIM: To longitudinally investigate early indicators of cardiovascular disease (CVD) in youths with Type 1 Diabetes Mellitus (T1DM) and their associations with novel metrics derived from con

Eirini Georeli

Circ_Mkrn2 facilitates the progression of atrial fibrillation via sponging miR-10b-5p

Cell Signal. 2026 Jan 29:112400. doi: 10.1016/j.cellsig.2026.112400. Online ahead of print.ABSTRACTChronic intermittent hypoxia (CIH) is the predominant pathophysiological disorder of obstructive sleep apnea (OSA), known to be an important risk factor for atrial fibrillation (AF). MicroRNA-10b-5p le

Yanshu Zhao

Prevalence and prognostic value of elevated soluble urokinase plasminogen activator receptor (suPAR) in patients admitted with acute heart failure

Int J Cardiol. 2026 Jan 29:134199. doi: 10.1016/j.ijcard.2026.134199. Online ahead of print.ABSTRACTBACKGROUND: The inflammatory biomarker, soluble urokinase plasminogen activator receptor (suPAR), has emerged as a promising prognostic biomarker in cardiovascular diseases. Currently little is known

Aginsha Kandiah

TRIM28 aggravates myocardial infarction-induced cardiomyocyte apoptosis through regulating the stability of ATF5 via ubiquitination and SUMOylation

Free Radic Biol Med. 2026 Jan 29:S0891-5849(26)00075-4. doi: 10.1016/j.freeradbiomed.2026.01.055. Online ahead of print.ABSTRACTMyocardial infarction (MI) stands as a leading contributor to global cardiovascular morbidity and mortality, defined by ischemic myocardial cell death and subsequent impair

Yanying Wang

Metabolic risk-attributable cardiovascular disease burden in adolescents and young adults, 1990-2050: a global burden of disease study

Endocr Pract. 2026 Jan 29:S1530-891X(26)00031-5. doi: 10.1016/j.eprac.2026.01.014. Online ahead of print.ABSTRACTOBJECTIVES: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, with metabolic risk factors (MRFs) playing a predominant role. This is of particular concern for a

Jing Chen

Long-term clinical outcomes and morphology of no-touch saphenous vein grafts

J Thorac Cardiovasc Surg. 2026 Jan 29:S0022-5223(26)00086-3. doi: 10.1016/j.jtcvs.2026.01.018. Online ahead of print.ABSTRACTOBJECTIVE: Coronary artery bypass grafting (CABG) with saphenous vein graft (SVG) is a standard treatment for coronary artery disease. The no-touch harvesting technique has sh

Atsushi Sugaya