Effects of intravenous furosemide plus small-volume hypertonic saline solutions on inflammatory, remodelling markers and epigenetics signatures of patients with congestive acute decompensated heart failure (ADHF)

Aging (Albany NY). 2026 Mar 26;18(1):190-212. doi: 10.18632/aging.206364. Epub 2026 Mar 26.ABSTRACTAIMS: In a randomised controlled trial (RCT), we compared the effects of treatment with furosemide + small volumes of hypertonic saline solution (HSS) with those of furosemide alone in patients with de

M Mario Daidone

Retinol saturase in the mitochondria antagonizes IDH2 and GLUD1 acetylation to mediate heart repair

Proc Natl Acad Sci U S A. 2026 Apr 7;123(14):e2526203123. doi: 10.1073/pnas.2526203123. Epub 2026 Mar 31.ABSTRACTFacilitating endogenous cardiomyocyte proliferation has emerged as an important strategy for cardiac repair. Conserved retinol saturase (Retsat) functions in producing all-trans 13,14-dih

W Wenya Ma

Safety and effectiveness of hormonal vs non-hormonal or no contraception in women with hypertension and future fertility desire: A broad-scope systematic review

PLoS One. 2026 Mar 31;21(3):e0345959. doi: 10.1371/journal.pone.0345959. eCollection 2026.ABSTRACTOBJECTIVE: To evaluate the safety and effectiveness of hormonal contraceptives compared to non-hormonal methods or no contraception in hypertensive women seeking future fertility.DATA SOURCES: Searches

N Natalia Losada-Trujillo

Large language model detects previously undiagnosed heart failure with preserved ejection fraction in patients with metabolic-associated fatty liver disease: A multicenter cohort study

PLOS Digit Health. 2026 Mar 31;5(3):e0001317. doi: 10.1371/journal.pdig.0001317. eCollection 2026 Mar.ABSTRACTMetabolic-associated fatty liver disease (MAFLD) and heart failure with preserved ejection fraction (HFpEF) share overlapping metabolic and inflammatory pathways, yet HFpEF is frequently und

X Xiaodan Lu

Characterizing inflammatory biomarkers in post-stroke seizure risk and outcome prognostication

PLoS One. 2026 Mar 31;21(3):e0345752. doi: 10.1371/journal.pone.0345752. eCollection 2026.ABSTRACTPost-stroke seizures (PSS) are sequelae of intracerebral hemorrhage (ICH) that may negatively impact patient outcomes. Available literature suggests that inflammatory biomarkers contribute to epileptoge

E Ethan Y Wang

Unmasking Hypercoagulability: Superior Sagittal Sinus Thrombosis Attributed to Pernicious Anemia in a Patient With Normal Hemoglobin Levels

Am J Case Rep. 2026 Mar 31;27:e951023. doi: 10.12659/AJCR.951023.ABSTRACTBACKGROUND Superior sagittal sinus thrombosis is an uncommon but serious cerebrovascular disorder, often linked to a hypercoagulable state. One less common etiology of hypercoagulability is elevated homocysteine levels due to v

T Tiwanna B Mclaughlin

Effect of finerenone treatment discontinuation on kidney and cardiovascular outcomes: a FIDELITY analysis

Am J Nephrol. 2026 Mar 31:1-20. doi: 10.1159/000549873. Online ahead of print.ABSTRACTIntroduction Finerenone reduced the risk of heart and kidney events in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) in FIDELITY, a prespecified pooled analysis combining data from the phase

A Ajay K Singh

Melatonin's Regulatory Influence on Pyroptosis: Biological Characteristics and Therapeutic Potentials

Curr Top Med Chem. 2026 Mar 30. doi: 10.2174/0115680266438716260306051040. Online ahead of print.ABSTRACTThe dysregulation of pyroptosis, which is an inflammatory type of programmed cell death (PCD), plays a significant role in the development of various diseases. At the same time, melatonin has bee

F Farnoosh Seirafianpour

Outcomes of patients with hypertensive emergency managed in intensive vs intermediate care settings: a multihospital retrospective cohort study

Ann Am Thorac Soc. 2026 Apr 1;23(4):565-574. doi: 10.1093/annalsats/aaoaf048.ABSTRACTBACKGROUND: Hypertensive emergency is characterized by end-organ dysfunction due to markedly elevated blood pressure. Although guidelines recommend rapid blood pressure lowering with intravenous antihypertensives an

C Chad H Hochberg

Effects of semaglutide on obstructive sleep apnea risk and outcomes in patients with obesity

Ann Am Thorac Soc. 2026 Apr 1;23(4):584-596. doi: 10.1093/annalsats/aaoaf070.ABSTRACTOBJECTIVES: This study investigates the impact of semaglutide on obstructive sleep apnea (OSA) risk and clinical outcomes in individuals with obesity.METHODS: A retrospective cohort study was conducted using the Tri

J Jheng-Yan Wu

Association between metered-dose inhaler confidence and misuse among adults with asthma or chronic obstructive pulmonary disease

No abstractAnn Am Thorac Soc. 2026 Apr 1;23(4):651-656. doi: 10.1093/annalsats/aaoaf069.NO ABSTRACTPMID:41915549 | DOI:10.1093/annalsats/aaoaf069

N Nadia Liyanage-Don

Complementary multi-omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes

Animal Model Exp Med. 2026 Mar 31. doi: 10.1002/ame2.70166. Online ahead of print.ABSTRACTBACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) is driven by unresolved pulmonary arterial thrombi and involves complex processes such as vascular remodeling and immune dysregulation. Early id

X Xiaopeng Liu

ADAMTS and ADAMTSL mutations in connective tissue disorders

Physiology (Bethesda). 2026 Mar 31. doi: 10.1152/physiol.00043.2025. Online ahead of print.ABSTRACTThe ADAMTS family are extracellular matrix (ECM) proteins and enzymes involved in regulating tissue structure and function. The ECM is a network of proteins and polysaccharides surrounding the cells th

A Ana D Alcocer

The Role of the Three-Dimensional Systolic Dyssynchrony Index and Autonomic Dysfunction Parameters in Detecting Subclinical Cardiac Involvement in Ankylosing Spondylitis

Echocardiography. 2026 Apr;43(4):e70430. doi: 10.1111/echo.70430.ABSTRACTOBJECTIVE: Ankylosing spondylitis (AS) is associated with an increased risk of cardiovascular complications, often subclinical. This study aimed to comprehensively investigate subclinical cardiac dysfunction using two- and thre

K Kutluhan Eren Hazir

Cardiovascular and Renal Outcomes Among Kidney Transplant Recipients With Metabolic Syndrome: A Systematic Review and Meta-Analysis

Clin Transplant. 2026 Apr;40(4):e70519. doi: 10.1111/ctr.70519.ABSTRACTBACKGROUND: Kidney transplant recipients (KTRs) are at elevated risk for metabolic syndrome (MS), primarily due to the side effects of immunosuppressive therapy. Emerging evidence suggests that MS may be associated with adverse o

M Min Yie Lim

Right Ventricular Functional Changes in Patients Undergoing Bone Marrow Transplantation: An Advanced Echocardiographic Analysis

Echocardiography. 2026 Apr;43(4):e70437. doi: 10.1111/echo.70437.ABSTRACTOBJECTIVE: This study aimed to evaluate right ventricular (RV) function pre and post bone marrow transplantation (BMT) using transthoracic echocardiography (TTE), in order to detect subclinical or clinical RV dysfunction that m

G Goktug Ugurluoglu

How do trait self-control constructs and discounting relate to each other and to modifiable risk factors for cardiovascular disease?

J Behav Med. 2026 Mar 31. doi: 10.1007/s10865-026-00640-y. Online ahead of print.ABSTRACTPURPOSE: This study examines how different trait self-control constructs and discounting relate to each other and to modifiable behavioral and cardiometabolic risk factors for cardiovascular disease (CVD). Data

L Lili L Kókai

Hydrogen as a Potential Modulator: Implications for Mast Cell-Sleep-Wake Rhythm-Melatonin Interactions in Sleep Disorders

Mol Neurobiol. 2026 Mar 31;63(1):541. doi: 10.1007/s12035-026-05824-w.ABSTRACTThe pathogenesis of sleep disorders, particularly chronic insomnia, obstructive sleep apnea (OSA), and sleep fragmentation (a symptom within the spectrum of chronic sleep deprivation-related sleep disturbances, rather than

C Chao Cui

No-reflow phenomenon after vessel recanalization in acute ischemic stroke: mechanisms, diagnosis, and treatment directions

J Neurol. 2026 Mar 31;273(4):238. doi: 10.1007/s00415-026-13783-4.ABSTRACTReperfusion therapy is the main treatment strategy for acute ischemic stroke (AIS). The no-reflow phenomenon (NRP) refers to the persistent impairment of microvascular tissue reperfusion after successful recanalization of larg

X Xueru Zhang

Pediatric vertebral artery dissection and ischemic stroke following chiropractic manipulation

Childs Nerv Syst. 2026 Mar 31;42(1):141. doi: 10.1007/s00381-026-07229-5.ABSTRACTPediatric vertebral artery dissection (VAD) following chiropractic cervical manipulation (CCM) is a rare phenomenon. As chiropractic care of pediatric populations increases internationally, it is imperative to increase

J Jonathan C Arnold

Pathophysiology of homocysteine: insights into ion channel dysfunction

No abstractPflugers Arch. 2026 Mar 31;478(4):35. doi: 10.1007/s00424-026-03165-0.NO ABSTRACTPMID:41915221 | DOI:10.1007/s00424-026-03165-0

N Nikola Chmúrčiaková

Haemostatic changes during CART cell therapy and risk of complications

Cancer Immunol Immunother. 2026 Mar 31;75(4):130. doi: 10.1007/s00262-026-04371-6.ABSTRACTChimeric antigen receptor T cell (CART) therapy toxicity includes cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), but also thrombotic and haemorrhagic events. Gi

M María Panizo-Inogés

Genotype-phenotype correlations and protein domain-level predictors of cerebrovascular malformations in hereditary hemorrhagic telangiectasia

J Neurol. 2026 Mar 31;273(4):237. doi: 10.1007/s00415-026-13777-2.ABSTRACTBACKGROUND: Hereditary Hemorrhagic Telangiectasia (HHT) exhibits marked phenotypic heterogeneity. Although gene-organ associations are well established for visceral involvement, predictors of cerebrovascular malformations (CVM

C Carmelo Lucio Sturiale

Trimethylamine N-oxide (TMAO) disrupts endothelial junction integrity through VE-cadherin Tyr658 phosphorylation in vitro

Arch Toxicol. 2026 Mar 31. doi: 10.1007/s00204-026-04368-1. Online ahead of print.ABSTRACTEndothelial dysfunction induced by the accumulation of uremic toxins is a key contributor to cardiovascular disease (CVD) in patients with chronic kidney disease (CKD), as increased endothelial permeability rep

C Carolina Amaral Bueno Azevedo