2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Circulation. 2025 Dec 18. doi: 10.1161/CIR.0000000000001402. Online ahead of print.ABSTRACTAIM: The "2025 ACC/AHA/HRS/ISACHD/SCAI Guideline for the Management of Adults With Congenital Heart Disease" provides recommendations to guide clinicians on the evaluation and treatment of adult patients with

M Michelle Gurvitz

Visual prediction of outcomes in patients undergoing intravenous thrombolysis

PLoS One. 2025 Dec 18;20(12):e0336226. doi: 10.1371/journal.pone.0336226. eCollection 2025.ABSTRACTBACKGROUND: This research presents a novel visual predictive model aimed at the early identification of patients at elevated risk of poor prognosis following intravenous thrombolysis, assessed six mont

Q Qing Liang

PERADIGM: Phenotype embedding similarity-based rare disease gene mapping

PLoS Genet. 2025 Dec 18;21(12):e1011976. doi: 10.1371/journal.pgen.1011976. eCollection 2025 Dec.ABSTRACTIdentifying genes associated with rare diseases remains challenging due to the scarcity of patients and the limited statistical power of traditional association methods. Here, we introduce PERADI

W Wangjie Zheng