An ageing biomarker signature predicts chronic disease cluster trajectories, physical function and mortality: validation in the TILDA and HRS cohorts

Age Ageing. 2026 May 4;55(5):afag135. doi: 10.1093/ageing/afag135.ABSTRACTBACKGROUND: Global population ageing is progressing at an unprecedented rate. Early identification of subpopulations at risk of chronic diseases could mitigate deteriorating health and increasing health service use, while reve

B Belinda Hernández

Smoking Cessation, Weight Change, and Risk of Dementia: A Prospective Cohort Study

Neurology. 2026 Jun 23;106(12):e218123. doi: 10.1212/WNL.0000000000218123. Epub 2026 May 20.ABSTRACTBACKGROUND AND OBJECTIVES: Smoking cessation is universally prioritized for the prevention of cardiovascular disease and cancer, but its impact on dementia risk remains uncertain. We aimed to evaluate

H Hui Chen

Diagnostic Agreement and Prognostic Value of Clinically Interpreted CT vs MRI for Incidentally Discovered Covert Cerebrovascular Disease

Neurology. 2026 Jun 23;106(12):e218058. doi: 10.1212/WNL.0000000000218058. Epub 2026 May 20.ABSTRACTBACKGROUND AND OBJECTIVES: Studies of covert cerebrovascular disease (CCD) typically rely on MRI screening, whereas CT is the predominant imaging modality in routine care. We aimed to determine the di

D David M Kent

Polyphenol-rich Salicornia extract in lacunar stroke: a pilot randomised trial of safety and exploratory clinical outcomes

Eur Stroke J. 2026 May 6;11(5):aakag049. doi: 10.1093/esj/aakag049.ABSTRACTINTRODUCTION: Cerebral small vessel disease is a major cause of lacunar stroke and vascular cognitive impairment, for which effective disease-modifying treatments are lacking. Polyphenols have shown neurovascular and neuropro

S Soledad Pérez-Sánchez

Alignment Between Cardiologists and AI-Driven Diagnostic Systems: Mixed Methods Study

J Med Internet Res. 2026 May 20;28:e83541. doi: 10.2196/83541.ABSTRACTBACKGROUND: The clinical value of artificial intelligence (AI)-based diagnostic systems depends not only on their accuracy but also on how well their outputs integrate with clinicians' judgments in practice. Critical knowledge gap

M Mahdi Mahdavi

Screening for physical frailty in older patients with cardiovascular disease and cognitive decline: one tool does not fit all

No abstractEur J Cardiovasc Nurs. 2026 May 20:zvag106. doi: 10.1093/eurjcn/zvag106. Online ahead of print.NO ABSTRACTPMID:42160736 | DOI:10.1093/eurjcn/zvag106

I Irene Instenes

Frailty-Based Remote Monitoring in Older Adults With Heart Failure: Conceptual Framework for Adaptive Digital Health Strategies

J Med Internet Res. 2026 May 20;28:e88681. doi: 10.2196/88681.ABSTRACTRemote monitoring is increasingly used in heart failure care, but most programs rely on uniform models that insufficiently reflect the heterogeneity of older adults, particularly with respect to frailty, cognitive impairment, func

R Rémi Esser

Postangiography Prediction of Renal Replacement Therapy in Acute Myocardial Infarction-Related Cardiogenic Shock: Least Absolute Shrinkage and Selection Operator Nomogram Development and Validation

JMIR Cardio. 2026 May 20;10:e79678. doi: 10.2196/79678.ABSTRACTBACKGROUND: Acute kidney injury critically impacts outcomes in cardiogenic shock secondary to acute myocardial infarction (CS-AMI). Acute kidney injury is one of the strongest independent predictors of in-hospital mortality in CS-AMI. De

A Amin Daoulah

Association of ATP2B1 and STK39 gene variants with blood pressure levels in patients with essential hypertension

Lab Med. 2026 Apr 3;57(3):lmag025. doi: 10.1093/labmed/lmag025.ABSTRACTINTRODUCTION: ATP2B1 and STK39 loci influence blood pressure in genome-wide association studies. We tested whether ATP2B1 rs2681472 and STK39 rs35929607 are associated with essential hypertension and blood pressure.METHODS: We st

E Egemen Akgün

Precision Prescribing of SGLT2 Inhibitors in Individuals With Type 2 Diabetes for Primary Prevention of Heart Failure: Model Development and Validation Study

Diabetes Care. 2026 Jun 1;49(6):1115-1123. doi: 10.2337/dc25-2973.ABSTRACTOBJECTIVE: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce heart failure (HF) risk in type 2 diabetes (T2D) and are recommended for patients with T2D who have atherosclerotic cardiovascular disease (ASCVD), HF, or ch

K Katherine G Young

Effect of surfactant administration in respiratory distress syndrome in terms of radiological changes in preterm infants: A multi-centre study

J Pak Med Assoc. 2026 Apr;76(4):541-545. doi: 10.47391/JPMA.22923.ABSTRACTOBJECTIVE: To evaluate the immediate clinical and radiological outcomes of surfactant administration in preterm newborns with respiratory distress syndrome.METHODS: The multicentre cohort study was conducted from January to Au

I Irum Qaisar

Lean and Non-obese Metabolic Dysfunction Associated Steatotic Liver Disease in Diabetics and Gender-wise association in a Low-income country

J Pak Med Assoc. 2026 Apr;76(4):530-534. doi: 10.47391/JPMA.22571.ABSTRACTOBJECTIVES: To assess the prevalence of lean, non-obese and obese metabolic dysfunction-associated steatotic liver disease in diabetics, and to explore gender-wise correlation of lifestyle, hypertension and dyslipidaemia with

F Falak Naz Malik

Assessing the impact of quality of life and complications on diabetes distress in adults with Type 2 Diabetes

J Pak Med Assoc. 2026 Apr;76(4):503-508. doi: 10.47391/JPMA.21516.ABSTRACTOBJECTIVES: To evaluate the relationship between f diabetes distress level and quality of life in individuals diagnosed with type 2 diabetes mellitus.METHODS: The cross-sectional study was conducted at the Endocrinology Polycl

G Gulsen Can

Rising Hypertension Mortality Rates Are Independent of Coding Drift

No abstractHypertension. 2026 Jun;83(6):e26694. doi: 10.1161/HYPERTENSIONAHA.126.26694. Epub 2026 May 20.NO ABSTRACTPMID:42160499 | DOI:10.1161/HYPERTENSIONAHA.126.26694

A Adith S Arun

Stress and Coronary Vascular Dysfunction in Women With Prior Preeclampsia

No abstractHypertension. 2026 Jun;83(6):e26760. doi: 10.1161/HYPERTENSIONAHA.126.26760. Epub 2026 May 20.NO ABSTRACTPMID:42160493 | DOI:10.1161/HYPERTENSIONAHA.126.26760

Y Yaa A Kwapong

Regional Anesthesia in Patients with Hepatic Failure: How Risky is it to Administer Local Anesthetic?

J Intensive Care Med. 2026 May 20:8850666261444973. doi: 10.1177/08850666261444973. Online ahead of print.ABSTRACTPatients with advanced liver disease challenge anesthesiologists, especially those providing regional anesthesia for postoperative pain management. Coagulopathy, encephalopathy, sepsis a

M Montather O Taheer

The immunoproteome and multimorbidity: A Mendelian randomization study

Sci Adv. 2026 May 22;12(21):eadz7117. doi: 10.1126/sciadv.adz7117. Epub 2026 May 20.ABSTRACTMultimorbidity presents challenges for research and health care. We investigated how immune-proteins influence multiple diseases to identify shared mechanisms and therapeutic opportunities. Using eight large

N Nikita Hukerikar

Shared diagnostic biomarkers in metabolic syndrome and coronary artery disease identified by integrated bioinformatics and machine learning

Endocr Connect. 2026 May 20:EC-26-0240. doi: 10.1530/EC-26-0240. Online ahead of print.ABSTRACTBACKGROUND: Metabolic syndrome (MetS) comprises various complicated metabolic disorders. Coronary artery disease (CAD) is a major cardiovascular disease worldwide. These two diseases are principal causes o

N Nuojin Wang

Spinal mechanisms and feasibility of Dry Needling versus Botulinum Toxin Type A in post-stroke lower limb spasticity: A proof-of-concept randomized clinical trial protocol (STROKE-POC)

PLoS One. 2026 May 20;21(5):e0334571. doi: 10.1371/journal.pone.0334571. eCollection 2026.ABSTRACTINTRODUCTION: Stroke often causes spasticity, impacting mobility and quality of life. Botulinum Toxin type A (BTX-A) and Dry Needling (DN) are treatments that reduce spasticity, although Botulinum Toxin

C Clara Pujol-Fuentes

Association between serum 25-hydroxyvitamin D levels and Early Vascular Aging in young and middle-aged adults

PLoS One. 2026 May 20;21(5):e0349409. doi: 10.1371/journal.pone.0349409. eCollection 2026.ABSTRACTBACKGROUND: Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity worldwide. Early vascular aging (EVA) is an independent predictor of cardiovascular risk in young and middle

J Jinpeng Cong

Exercise-based cardiac rehabilitation and atherosclerotic plaque regression in ASCVD: Is exercise really a game-changer? A scoping review of controlled trials

PLoS One. 2026 May 20;21(5):e0347557. doi: 10.1371/journal.pone.0347557. eCollection 2026.ABSTRACTExercise-based cardiac rehabilitation (CR) has emerged as a promising strategy for promoting atherosclerotic plaque regression in patients with atherosclerotic cardiovascular disease (ASCVD). Although l

D Dwita Rian Desandri

The association between platelet-to-albumin ratio and diabetic peripheral neuropathy: A cross-sectional study in the Chinese population

PLoS One. 2026 May 20;21(5):e0348402. doi: 10.1371/journal.pone.0348402. eCollection 2026.ABSTRACTINTRODUCTION: The early prevention and diagnosis of diabetic complications are challenging, particularly for diabetic peripheral neuropathy (DPN), which progresses insidiously and irreversibly. Currentl

W Wenting Deng

Graded Severity of Aortic Valve Sclerosis as an Independent Clinical Marker of Systemic Disease, Diastolic Dysfunction, and Mortality Risk: A Large Echocardiographic Cohort Study

Cardiology. 2026 May 20:1-21. doi: 10.1159/000552614. Online ahead of print.ABSTRACTBACKGROUND: Aortic valve sclerosis (AVS) is highly prevalent in the elderly. However, the prognostic implications of different degrees of echocardiographic AVS severity, and its association with comorbidities, myocar

I Israel Gotsman

From evidence to implementation: workforce development and team-based care lessons from the WHO Hypertension 2023 & 2025 report

J Hypertens. 2026 Apr 28. doi: 10.1097/HJH.0000000000004321. Online ahead of print.ABSTRACTThe World Health Oragnization (WHO) 2025 Global Report on Hypertension builds upon the 2023 publication titled "The Race Against a Silent Killer". While the 2023 report recommends the HEARTS technical package

T Thomas Hinneh