Exosomes displaying native EGF enhance doxorubicin's therapeutic efficacy and reduce cardiotoxicity

J Nanobiotechnology. 2026 Jan 27. doi: 10.1186/s12951-025-04002-9. Online ahead of print.ABSTRACTBACKGROUND: Doxorubicin (DOX) is one of the most potent chemotherapeutic agents for cancer treatment. However, its cumulative and often irreversible, life-threatening cardiotoxicity significantly limits

L Liang Mao

Cardiovascular health metrics among an Iranian population: insights from life's essential 8

No abstractBMC Cardiovasc Disord. 2026 Jan 27. doi: 10.1186/s12872-025-05201-w. Online ahead of print.NO ABSTRACTPMID:41593512 | DOI:10.1186/s12872-025-05201-w

T Toba Kazemi

Rat models for arterial calcification associated with chronic kidney disease: a systematic review and meta-analysis

BMC Cardiovasc Disord. 2026 Jan 27;26(1):82. doi: 10.1186/s12872-025-05471-4.ABSTRACTArterial calcification represents a major burden in chronic kidney disease (CKD) and is an independent risk factor for cardiovascular diseases (CVD). Rodent models are essential for preclinical research on arterial

N Nicolas Hense

Association of HDL subclass components with all-cause and cardiovascular mortality: a prospective cohort study based on the ChinaHEART project

Lipids Health Dis. 2026 Jan 27. doi: 10.1186/s12944-026-02874-w. Online ahead of print.ABSTRACTBACKGROUND: While the U-shaped association between high-density lipoprotein cholesterol (HDL-C) levels and the risk of all-cause and cardiovascular mortality is well-established, the underlying contributio

X Xuan Liu

Association between cognitive function and all-cause mortality among US older adults with cardiovascular-kidney-metabolic syndrome

No abstractBMC Geriatr. 2026 Jan 28. doi: 10.1186/s12877-026-07055-z. Online ahead of print.NO ABSTRACTPMID:41593441 | DOI:10.1186/s12877-026-07055-z

Z Zhaorong Lin

β-Carboline alkaloid harmaline alleviates hyperuricemia-mediated renal inflammation by suppressing oxidative stress

Naunyn Schmiedebergs Arch Pharmacol. 2026 Jan 28. doi: 10.1007/s00210-026-04987-6. Online ahead of print.ABSTRACTHyperuricemia is a metabolic disorder marked by elevated serum uric acid levels and is closely linked to the development of gout and progressive renal dysfunction. It is increasingly reco

A Ayush Kattna

Postpartum cardio-obstetrics rehabilitation program for women after hypertensive pregnancy: A single-arm proof-of-concept study

Hypertens Res. 2026 Jan 28. doi: 10.1038/s41440-026-02556-1. Online ahead of print.ABSTRACTHypertensive disorders during pregnancy increase the risk of long-term cardiovascular disease in postpartum women. Exercise-based rehabilitation may help manage blood pressure (BP) and improve physical activit

K Karan Pongpanit

Angiotensinogen and its relationship with blood pressure in young adults: the African-PREDICT study

J Hum Hypertens. 2026 Jan 27. doi: 10.1038/s41371-026-01112-1. Online ahead of print.ABSTRACTThe renin-angiotensin-aldosterone system (RAAS) plays a central role in blood pressure (BP) control through its downstream components including angiotensin II and aldosterone. However, recent data show that

N Noncedo Nontando Maseko

High prevalence of polypharmacy and nervous system medications in people with HIV: a cross-sectional analysis

Sci Rep. 2026 Jan 27. doi: 10.1038/s41598-026-36832-4. Online ahead of print.ABSTRACTPolypharmacy is increasingly prevalent among people living with HIV (PLWH), especially as they age and manage multiple comorbidities. This cross-sectional study analyzed data from 268 PLWH in Vigo, Spain (2020-2023)

A Aida López López

Plasma fatty acid profiles and coronary artery disease burden assessed by coronary CT angiography: an observational study

No abstractSci Rep. 2026 Jan 27. doi: 10.1038/s41598-026-36845-z. Online ahead of print.NO ABSTRACTPMID:41593269 | DOI:10.1038/s41598-026-36845-z

P Pich Chhay

Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues

Nat Metab. 2026 Jan 27. doi: 10.1038/s42255-025-01444-1. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is a prevalent disease arising from complex molecular mechanisms. Here we leverage T2D genetic associations to identify causal molecular mechanisms in an ancestry-aware and tissue-aware manne

O Ozvan Bocher

Multimodal single-cell profiling reveals crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients

NPJ Precis Oncol. 2026 Jan 28. doi: 10.1038/s41698-026-01292-6. Online ahead of print.ABSTRACTCholangiocarcinoma (CCA) is a deadly cancer, characterized by abundant stroma. The tumor microenvironment (TME) plays an important role in its aggressive behavior and poor response to therapeutics; however,

L Lara Heij

ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications

Acta Pharmacol Sin. 2026 Jan 27. doi: 10.1038/s41401-025-01724-2. Online ahead of print.ABSTRACTThe endoplasmic reticulum (ER) is a central organelle for protein synthesis and folding, lipid metabolism and calcium signaling, etc. To maintain ER homeostasis, cells employ a specific autophagy process

W Wen-Jing Yang

Human germline-like monoclonal antibody against 5T4 enables potent ADC and CAR-T therapies for solid tumors

Acta Pharmacol Sin. 2026 Jan 27. doi: 10.1038/s41401-025-01731-3. Online ahead of print.ABSTRACT5T4 is an oncofetal antigen overexpressed in a wide range of solid tumors with minimal presence in normal adult tissues, highlighting its promise as a therapeutic target. In this study, we identified germ

Y Yi-Qing Jiang

Mechanisms, precision therapies, and technological frontiers in coronary atherosclerosis: a comprehensive review

Acta Pharmacol Sin. 2026 Jan 27. doi: 10.1038/s41401-025-01729-x. Online ahead of print.ABSTRACTCoronary atherosclerosis is a leading cause of morbidity and mortality worldwide and is characterized by complex molecular and cellular mechanisms involving lipid dysregulation, endothelial dysfunction, i

Z Zi-Xuan Qiu

Oligoprotein type I interferon signatures, but not TREX1 variants, increase risk of systemic lupus erythematosus in UK Biobank

Nat Commun. 2026 Jan 27. doi: 10.1038/s41467-025-67832-z. Online ahead of print.ABSTRACTThe 3' - 5' DNA exonuclease, TREX1, is a negative regulator of the type I interferon response, while TREX1 variants are considered to confer risk for non-monogenic systemic lupus erythematosus (SLE). Here we anal

B Bastien Rioux

Mechanistic insights into heart failure progression and therapeutic target discovery through plasma microRNA profiling: Findings from HOMAGE

Eur J Intern Med. 2026 Jan 26:106724. doi: 10.1016/j.ejim.2026.106724. Online ahead of print.ABSTRACTBACKGROUND: Identifying early pathobiological mechanisms associated with the onset and progression of heart failure (HF) could guide development of preventive strategies.OBJECTIVE: To elucidate molec

D David de Gonzalo-Calvo

Amblyopia and adult health: a comprehensive analysis of long-term systemic, sensory and mental health comorbidities in a national cohort

Br J Ophthalmol. 2026 Jan 27:bjo-2025-328653. doi: 10.1136/bjo-2025-328653. Online ahead of print.ABSTRACTAIMS: To evaluate the adult health consequences of amblyopia, including sensory deficits, mental health, physical activity and cardiovascular health.METHODS: A cross-sectional study using data f

K Kyoung A Viola Lee

Artificial Intelligence to Guide Repurposing of Drugs

Annu Rev Med. 2026 Jan;77(1):381-398. doi: 10.1146/annurev-med-050224-122802.ABSTRACTWith the pharmacokinetics, dosing, safety, and manufacturing of approved or investigational drugs already well-characterized, drug repurposing and repositioning offer emerging strategies to rapidly develop effective

Z Zhimin Fu

Minimally invasive versus conventional mitral valve surgery: a systematic review and meta-analysis of randomised clinical trials

Open Heart. 2026 Jan 27;13(1):e003612. doi: 10.1136/openhrt-2025-003612.ABSTRACTBACKGROUND: The benefits of minimally invasive mitral valve surgery (MIMVS) compared with conventional approaches (CMVS, conventional mitral valve surgery) remain controversial. We conducted a systematic review and meta-

F Felipe Abatti Spadini

Proteomic footprint of serum urate concentration and urate transporter ABCG2 dysfunctional polymorphism: a cross-sectional study

RMD Open. 2026 Jan 27;12(1):e006414. doi: 10.1136/rmdopen-2025-006414.ABSTRACTBACKGROUND: Existing proteomic studies have primarily focused on gout flares or symptomatic hyperuricaemia, and few have comprehensively investigated circulating proteomic profiles in serum urate (SU) concentration as a co

Y Yuki Ohashi

The value of measuring waist circumference in primary care: a mixed-methods study

Br J Gen Pract. 2026 Jan 27:BJGP.2025.0395. doi: 10.3399/BJGP.2025.0395. Online ahead of print.ABSTRACTBACKGROUND: It remains a challenge for GPs to identify all patients at increased risk of cardiovascular disease (CVD) in their practice, as performing cardiovascular risk assessment in every single

W Willemijn J van den Hout

Bridging the gap in the UK's National Health Service integrated care systems: insights from a mixed methods implementation evaluation of UCLP-PRIMROSE, a care innovation to reduce physical health inequalities for people with severe mental illness

BMJ Open. 2026 Jan 27;16(1):e105511. doi: 10.1136/bmjopen-2025-105511.ABSTRACTOBJECTIVE: We aimed to determine whether UCLP-PRIMROSE (a care innovation to reduce physical health inequalities for people with severe mental illness) could be set up in the current UK National Health Service (NHS) contex

P Philippa Shaw

Computed tomography coronary angiography to facilitate clinical decision-making and selective invasive angiography in patients with prior bypass grafting presenting with acute coronary syndromes

Heart. 2026 Jan 27:heartjnl-2025-326961. doi: 10.1136/heartjnl-2025-326961. Online ahead of print.ABSTRACTBACKGROUND: Patients with prior coronary artery bypass grafting (CABG) account for around 10% of non-ST-elevation acute coronary syndromes (NSTE-ACS), but the optimal diagnostic and management s

M Matthew Kelham