Machine learning-based prediction of atherosclerotic cardiovascular disease risk in adults with diabetes or prediabetes

No abstractBMC Cardiovasc Disord. 2025 Dec 4. doi: 10.1186/s12872-025-05247-w. Online ahead of print.NO ABSTRACTPMID:41345827 | DOI:10.1186/s12872-025-05247-w

Y Yang Li

Distal Placement of Guide Catheter Improves Efficacy of Endovascular Thrombectomy in Large Vessel Occlusion Stroke: a Systematic Review and Meta-analysis

Clin Neuroradiol. 2025 Dec 4. doi: 10.1007/s00062-025-01596-3. Online ahead of print.ABSTRACTPURPOSE: The impact of distal guide catheter placement on clinical outcomes for endovascular thrombectomy (EVT) in large vessel occlusion (LVO) stroke remains uncertain. This systematic review and meta-analy

X Xin Jiang

Perirenal fat: a missing link between mineralocorticoid receptor activation and cardiovascular-kidney-metabolic syndrome in primary aldosteronism

No abstractHypertens Res. 2025 Dec 4. doi: 10.1038/s41440-025-02498-0. Online ahead of print.NO ABSTRACTPMID:41345780 | DOI:10.1038/s41440-025-02498-0

K Koro Gotoh

Higher Dietary Insulinemic Potential, and Triglyceride-Glucose (TyG)-BMI Index may Contribute to Coronary Artery Disease Severity: a Cross-Sectional Study

J Epidemiol Glob Health. 2025 Dec 4. doi: 10.1007/s44197-025-00493-9. Online ahead of print.ABSTRACTBACKGROUND: Emerging evidence suggests that insulin resistance (IR) may influence coronary artery disease (CAD) progression. However, the relationship between dietary insulinemic potential and IR surr

M Marjan Mahdavi-Roshan

Advanced multifunctional nano-delivery platform focusing on treating diseases related to lipid metabolism via targeted intervention in various lipid metabolic processes

Mil Med Res. 2025 Dec 4;12(1):87. doi: 10.1186/s40779-025-00672-6.ABSTRACTDisruptions in lipid metabolism cause numerous metabolic diseases, including obesity, diabetes, cardiovascular diseases, and liver disorders. Consequently, lipid metabolism serves as a potential therapeutic target, influencing

Y Ying Sun

Development and validation of nomograms to predict brain metastasis-free survival in lung and breast cancer

Cancer Imaging. 2025 Dec 5. doi: 10.1186/s40644-025-00969-8. Online ahead of print.ABSTRACTPrimary lung cancer (LC) and breast cancer (BC) are among the most common malignancies and are highly prone to brain metastasis (BM). This study aimed to identify risk factors for brain metastasis-free surviva

B Bo Wang

Old dogs-new tricks: multifaceted functions of MAVS beyond antivirus activity in human health and diseases

Cell Biosci. 2025 Dec 4. doi: 10.1186/s13578-025-01512-9. Online ahead of print.ABSTRACTMitochondrial Antiviral Signaling Protein (MAVS), a key adaptor in the innate immune system, has traditionally been recognized for its role in defending against viral infections through activation of the interfer

Y Yating Lu

Reducing Anticholinergic Burden in Hospitalised Older Adults: Analysis From the INFAR Study

Basic Clin Pharmacol Toxicol. 2026 Jan;138(1):e70160. doi: 10.1111/bcpt.70160.ABSTRACTThis study aimed to evaluate the effectiveness of pharmacist-led medication reviews in reducing the anticholinergic burden of hospitalised patients with cardiovascular diseases (CVDs), to identify which anticholine

R Romana Santos Gama

Exploring barriers to hypertension medication adherence among people living with HIV enrolled in the iHEART-SA trial: a theoretical domains framework qualitative study

BMC Public Health. 2025 Dec 4. doi: 10.1186/s12889-025-25683-9. Online ahead of print.ABSTRACTBACKGROUND: Hypertension significantly increases the risk of cardiovascular complications, posing a dual burden for people living with HIV (PLHIV) in Sub-Saharan Africa. This study explores the barriers and

W Wellington Maruma

Folate-modified biomimetic nanovesicles loaded with a PU.1 inhibitor alleviate atherosclerosis by suppressing inflammation

J Nanobiotechnology. 2025 Dec 5. doi: 10.1186/s12951-025-03825-w. Online ahead of print.ABSTRACTAtherosclerosis is a chronic inflammatory disease affecting arterial walls and remains a leading cause of morbidity and mortality worldwide. While anti-inflammatory therapy is widely recognized as a criti

L Leye Yan

Incidence and predictors of cardiovascular disease among hypertension patients in, Ethiopia: a retrospective follow-up study

No abstractBMC Cardiovasc Disord. 2025 Dec 4. doi: 10.1186/s12872-025-05280-9. Online ahead of print.NO ABSTRACTPMID:41345562 | DOI:10.1186/s12872-025-05280-9

K Kagnew Getachew

ETV1 orchestrates a self-reinforcing ERK1/2-RSK3 signaling loop to drive atrial fibrillation pathogenesis: implications for targeted therapy

Sci Rep. 2025 Dec 4;15(1):43176. doi: 10.1038/s41598-025-27341-x.ABSTRACTAs the most prevalent sustained cardiac arrhythmia, atrial fibrillation (AF) remains incompletely characterized in terms of its molecular drivers. This investigation seeks to systematically identify critical molecular determina

M Meiqiong Wu

Perceived determinants of clinical practice guideline implementation for stroke rehabilitation in LMICs a multinational REFORM survey

Sci Rep. 2025 Dec 4;15(1):43120. doi: 10.1038/s41598-025-16738-3.ABSTRACTImplementation of clinical practice guidelines (CPGs) is integral to improving the quality of stroke rehabilitation in low- and middle-income countries (LMICs). However, various barriers hinder their effective utilization. This

D Dorcas Bc Gandhi

Deriving novel atrial fibrillation phenotypes using a tree-based artificial intelligence-enhanced electrocardiography approach

NPJ Digit Med. 2025 Dec 4. doi: 10.1038/s41746-025-02159-z. Online ahead of print.ABSTRACTAtrial fibrillation (AF) is classically categorised by arrhythmia duration, but these subtypes have limitations in capturing mechanistic and prognostic diversity. A variational autoencoder, trained on >1.1M ECG

M Mehak Gurnani

Astragaloside IV attenuates uremia-induced myocardial injury by inhibiting autophagy via ATF4

Sci Rep. 2025 Dec 4. doi: 10.1038/s41598-025-30374-x. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular diseases (CVDs) are one of the primary causes of mortality in patients with uremia. The therapeutic value of intravenous Astragaloside (AS-IV) in the treatment of CVDs has been widely recog

J Jihao Xu

Association of hearing loss with cardiovascular and mortality risk in the general population

Sci Rep. 2025 Dec 5. doi: 10.1038/s41598-025-27832-x. Online ahead of print.ABSTRACTHearing loss affects over 1.5 billion individuals worldwide and is associated with significant challenges, including social isolation and cognitive decline. Emerging evidence suggests a link between hearing loss and

O Omar Hahad

SPP1/OPN Alleviates Post-Intracerebral Hemorrhage Depression and Cognitive Impairment via Nrf2/BDNF Signaling Activation in Mice

CNS Neurosci Ther. 2025 Dec;31(12):e70680. doi: 10.1002/cns.70680.ABSTRACTBACKGROUND: Post-stroke depression represents a prevalent neuropsychiatric complication following intracerebral hemorrhage (ICH), yet its underlying mechanisms remain less understood compared to ischemic stroke.METHODS: This t

P Pengpeng Li

Machine learning identifies clinical and sociodemographic factors contributing to post-COVID hospitalization and cardiovascular risk in patients with peripheral artery disease

Sci Rep. 2025 Dec 5. doi: 10.1038/s41598-025-26468-1. Online ahead of print.ABSTRACTThis study aims to assess the impact of preexisting peripheral arterial disease (PAD) on adverse outcomes-including hospitalization and cardiovascular events-in COVID-19 patients, and to identify risk factors associa

A Ahsan Zil-E-Ali

Precision engineering of anti-atherosclerotic herbal nanomedicine: from machine learning-aided active components screening to optimized metal-phenolic network codelivery

Drug Deliv Transl Res. 2025 Dec 4. doi: 10.1007/s13346-025-02023-3. Online ahead of print.ABSTRACTAtherosclerosis (AS), a chronic inflammatory disease linked to oxidative stress and lipid imbalance, remains a major cardiovascular threat. Traditional herbs Salvia miltiorrhiza and Carthamus tinctorius

Y Yao Chen

Risk of intestinal complications, extraintestinal morbidity, and mortality in patients with ulcerative colitis and ocular involvement

Eye (Lond). 2025 Dec 4. doi: 10.1038/s41433-025-04151-z. Online ahead of print.ABSTRACTPURPOSE: To explore health outcomes of patients with ulcerative colitis (UC) and associated ocular inflammatory disease, compared to those of matched patients with UC without associated ocular inflammatory disease

B Brian K Do

Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models

Nat Commun. 2025 Dec 4;16(1):10909. doi: 10.1038/s41467-025-65873-y.ABSTRACTAtherosclerotic lesions show significant mitochondrial dysfunction but the underlying mechanisms and consequences remain unknown. Cardiolipin is a phospholipid found exclusively in the mitochondrial inner membrane, the site

C Cindy Dong

Bioinformatics analysis of immune-related differentially expressed genes in Kawasaki disease

Sci Rep. 2025 Dec 4. doi: 10.1038/s41598-025-30624-y. Online ahead of print.ABSTRACTKawasaki disease (KD) is an acute pediatric systemic vasculitis of unknown origin, where emerging evidence suggests that immune dysregulation and alterations in peripheral immune cell populations play critical roles

M Mengjia Zhao

Transthoracic echocardiography of left ventricular underfilling improves risk stratification in pulmonary arterial hypertension

Sci Rep. 2025 Dec 4. doi: 10.1038/s41598-025-28206-z. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is characterized by right ventricular (RV) adaptation to elevated afterload. However, the prognostic value of left ventricular (LV) underfilling in response to RV volume overload

A Ashfaq Ahmad

Mitochondria-targeted gene delivery using fluorinated lipid nanoparticles to alleviate Leber's hereditary optic neuropathy

Nat Commun. 2025 Dec 4;16(1):10891. doi: 10.1038/s41467-025-65874-x.ABSTRACTMutations in mitochondrial DNA (mtDNA) lead to various mitochondrial diseases for which no cure is currently available. Despite the promising potential of mtDNA correction to treat these disorders, the double mitochondrial m

Y Yi Wang