Cost-Effectiveness Analysis of Menopausal Hormone Therapy

Obstet Gynecol. 2026 Aug 13. doi: 10.1097/AOG.0000000000006404. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the cost effectiveness of menopausal hormone therapy (MHT) based on the risk-benefit profiles of current MHT formulations.METHODS: We used a Markov model to examine the cost effective

E Elizabeth Gill

Menopausal Estrogen Therapy and Risk of Breast Cancer

Obstet Gynecol. 2026 Aug 13. doi: 10.1097/AOG.0000000000006397. Online ahead of print.ABSTRACTRecent evidence suggests that use of menopausal estrogen-only therapy in patients who have undergone hysterectomy reduces breast cancer risk among patients at population risk for breast cancer as well as in

A Andrew M Kaunitz

Digital Health Technology for Improving Physical Function in Adults With Chronic Heart Failure: Systematic Review and Meta-Analysis of Randomized Controlled Trials

J Med Internet Res. 2026 Aug 13;28:e91820. doi: 10.2196/91820.ABSTRACTBACKGROUND: Chronic heart failure (CHF) significantly impairs physical function and quality of life. Although exercise-based cardiac rehabilitation represents a primary therapeutic strategy, participation rates remain low due to l

Z Zhe Meng

Whitia Kia Ora: a culturally responsive model of Bicillin L-A® delivery for people with rheumatic fever in the Waikato region of Aotearoa New Zealand

N Z Med J. 2026 Aug 14;139(1640):40-50. doi: 10.26635/6965.7394.ABSTRACTAIM: Acute rheumatic fever (ARF) is an autoimmune response to group A Streptococcus (Strep A) infection that can lead to rheumatic heart disease (RHD). To prevent Strep A infection for people with ARF or RHD, clinical guidelines

A Anneka Anderson

Protocol for a Sequential Multiple Assignment Randomized Trial to Improve Physical Activity and Diet Quality in Survivors of Cancer

JMIR Res Protoc. 2026 Aug 13;15:e104572. doi: 10.2196/104572.ABSTRACTBACKGROUND: Survivors of childhood cancer have an increased risk of cardiovascular disease (CVD), but that risk may be reduced by healthy lifestyle behaviors.OBJECTIVE: Using a sequential multiple assignment randomized trial (SMART

E Eric Chow

Association Between Body Roundness Index and Periodontitis in Adults With Hypertension: A Cross-Sectional Study

Clin Exp Dent Res. 2026 Aug;12(4):e70429. doi: 10.1002/cre2.70429.ABSTRACTOBJECTIVES: The association between body roundness index (BRI) and periodontitis among US adults with hypertension remains unclear. This study aimed to investigate the relationship between BRI and periodontitis in this populat

L Liting Xie

MiR-221-5p aggravates sepsis-induced myocardial injury by targeting neuropilin-1

J Immunol. 2026 Aug 4;215(8):vkag228. doi: 10.1093/jimmun/vkag228.ABSTRACTSepsis-induced cardiac dysfunction is a primary contributor to mortality, and microRNAs (miRNAs) are recognized as crucial mediators in sepsis pathogenesis. This study aims to identify the key regulatory miRNAs involved in car

Y Yike Zhu

The U-shaped association between serum fibrinogen level and poststroke epilepsy within 1 year of acute ischemic stroke

Lab Med. 2026 Aug 4;57(5):lmag046. doi: 10.1093/labmed/lmag046.ABSTRACTINTRODUCTION: As an indicator of coagulation function, the effect of circulating fibrinogen on cardiovascular and cerebrovascular diseases has been well studied, but the association between fibrinogen and poststroke epilepsy (PSE

Y Ying Zheng

Burden of high blood pressure and associated risk for all-cause and cardiovascular mortality among US young adults

Blood Press. 2026 Aug 13:1-16. doi: 10.1080/08037051.2026.2715846. Online ahead of print.ABSTRACTBACKGROUND: High blood pressure in young adults is an underrecognized public health issue with potential long-term health consequences, including increased mortality risk. To examine the prevalence of pr

M Ming Ying

Association of erythropoiesis-stimulating agents and red blood cell transfusion with venous thrombosis in patients with cancer: a nationwide case-crossover study

Ann Med. 2026 Dec;58(1):2716953. doi: 10.1080/07853890.2026.2716953. Epub 2026 Aug 13.ABSTRACTBACKGROUND: Cancer-associated anemia is commonly managed with erythropoiesis-stimulating agents (ESAs) and red blood cell (RBC) transfusions; however, their relative thrombotic risks remain uncertain.METHOD

B Byung-Hyun Lee

A cross-organ single-cell analysis of hypertension

Science. 2026 Aug 13;393(6812):eaea6187. doi: 10.1126/science.aea6187. Epub 2026 Aug 13.ABSTRACTHypertension is a leading cause of disease burden and mortality. Here, we present a single-cell analysis of hypertension and end-organ damage across six organs and tissues in angiotensin II-treated mice,

Q Qiongzi Qiu

AMPKγ2 Meets Myosin: A New Link Between Metabolism and Sarcomere Function

No abstractCirc Res. 2026 Aug 14;139(5):e329303. doi: 10.1161/CIRCRESAHA.126.329303. Epub 2026 Aug 13.NO ABSTRACTPMID:42594171 | DOI:10.1161/CIRCRESAHA.126.329303

S Shanshan Gao

Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation

Circ Res. 2026 Aug 14;139(5):e327198. doi: 10.1161/CIRCRESAHA.126.327198. Epub 2026 Aug 13.ABSTRACTCardiovascular diseases remain the leading global cause of mortality, highlighting the need for improved early detection and targeted interventions. Extracellular vesicles (EVs) are nano-sized, bilipid

M Michail Spanos

Platelet Reactivity and Sex Differences: Clinical Implications for Women

Circ Res. 2026 Aug 14;139(5):e328602. doi: 10.1161/CIRCRESAHA.126.328602. Epub 2026 Aug 13.ABSTRACTPlatelets are central to hemostasis and thrombosis. Excessive platelet activation contributes to arterial thrombotic events, including myocardial infarction, ischemic stroke, and complications of perip

A Anu Aggarwal

Shifting the Balance: Mitochondrial Heteroplasmy as a Driver of Cardiac Disease

Circ Res. 2026 Aug 14;139(5):e328769. doi: 10.1161/CIRCRESAHA.126.328769. Epub 2026 Aug 13.ABSTRACTMitochondrial heteroplasmy represents a fundamental determinant of mitochondrial function and disease, yet its consequences vary across different tissues. Although mitotic tissues possess mechanisms, s

A Andriana Papadaki

Improving the reliability of polygenic risk score-based prediction for cardiovascular and renal complications across ancestries in type 2 diabetes using Mondrian Cross-Conformal Prediction

PLoS Comput Biol. 2026 Aug 13;22(8):e1014670. doi: 10.1371/journal.pcbi.1014670. Online ahead of print.ABSTRACTPolygenic risk scores (PRS) developed in European populations often show reduced predictive performance in non-European populations, limiting their clinical utility. This lack of transferab

E Edoh Kodji

Targeted sequencing provides genetic insights into familial cardiovascular disease among young adults in a high consanguinity population

PLoS One. 2026 Aug 13;21(8):e0353861. doi: 10.1371/journal.pone.0353861. eCollection 2026.ABSTRACTBACKGROUND: Cardiovascular diseases (CVDs) account for approximately 19.8 million deaths annually, with coronary artery disease (CAD) as a major contributor. Genetic factors play an important role in CV

N Nauman Arif

Methodological development of a pneumatic artificial muscle-driven left ventricular simulator using interpretive structural modeling

PLoS One. 2026 Aug 13;21(8):e0355859. doi: 10.1371/journal.pone.0355859. eCollection 2026.ABSTRACTMock circulation systems can replicate a wide range of cardiac operating scenarios, such as cardiovascular diseases, particularly muscular dysfunctions. These systems are operated by sophisticated contr

T Turgut Batuhan Baturalp

Associations between dietary composition, water intake, urine pH, and cardiometabolic indicators among young Saudi women

PLoS One. 2026 Aug 13;21(8):e0355378. doi: 10.1371/journal.pone.0355378. eCollection 2026.ABSTRACTBACKGROUND: Cardiometabolic disorders continue to rise globally, yet limited evidence exists regarding the associations between dietary composition, hydration status, urine pH, and cardiometabolic risk

J Jozaa Z ALTamimi

Chronic kidney disease progression rate and predictors in hypertensive patients: A 5-year retrospective follow-up study in Ethiopia

PLoS One. 2026 Aug 13;21(8):e0355483. doi: 10.1371/journal.pone.0355483. eCollection 2026.ABSTRACTINTRODUCTION: Chronic kidney disease is a major public health concern worldwide. Despite the well-established link between hypertension and chronic kidney disease, early detection and management of chro

G Getaneh Atikilt Yemata

The impact of short-term reduction in hepatic triglycerides on vascular health in adults with or at risk of metabolic dysfunction-associated steatotic liver disease

PLoS One. 2026 Aug 13;21(8):e0345338. doi: 10.1371/journal.pone.0345338. eCollection 2026.ABSTRACTBACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) increases cardiovascular risk, but the vascular benefits of reducing hepatic triglycerides remain unclear.AIM: To determine w

T Tianyu Wang

The Evolving Premature Burden of Ischemic Stroke (GBD 2023) Among Adults Aged 50-69 Years in China, India, and the United States: A 34-Year Predictive Analysis Based on YLL/YLD Decomposition and ARIMA Models (1990-2053)

Neuroepidemiology. 2026 Aug 13:1. doi: 10.1159/ned/adwag005. Online ahead of print.ABSTRACTBACKGROUND: The younger onset of ischemic stroke creates a significant premature disease burden for adults aged 50-69. China, India, and the United States represent different stages of global epidemiological t

R Renda He

Sex-specific associations of the CALLY index with mortality in hypertension: Stronger relative protection in males but greater absolute benefit in females-a retrospective cohort study

Sci Prog. 2026 Jul-Sep;109(3):368504261479101. doi: 10.1177/00368504261479101. Epub 2026 Aug 13.ABSTRACTObjectiveInflammation, immunity, and nutrition are established factors in hypertension, but the prognostic role of the C-reactive protein-albumin-lymphocyte (CALLY) index remains undefined. We aim

Y Ying Xu

Imaging Review and Clinical Manifestations of Lacunar Stroke Syndromes

Radiographics. 2026 Sep;46(9):e250186. doi: 10.1148/rg.250186.ABSTRACTLacunar strokes are small subcortical infarcts that result from the occlusion of small perforating arteries, and they comprise about 25% of all strokes. Unlike other types of infarcts, lacunar strokes are primarily due to cerebral

K Kevin Ryan T Yu