Development of Blue-to-Near-Infrared rTCO-Caged Fluorogenic Probes for Click-to-Release Monitoring

Chemistry. 2026 Sep 21:e71703. doi: 10.1002/chem.71703. Online ahead of print.ABSTRACTBioorthogonal click-to-release reactions provide a powerful strategy for chemically controlled activation of functional molecules in biological systems. Here, we report the development of a series of 12 trans-cyclo

M Marek Chovanec

Effects of Empagliflozin on Cardiovascular Outcomes Are Consistent Across Sociodemographic Subgroups: A Real-World Analysis From the EMPRISE Study

Diabetes Care. 2026 Sep 21:dca260039. doi: 10.2337/dca26-0039. Online ahead of print.ABSTRACTOBJECTIVE: We aimed to explore the heterogeneity of empagliflozin treatment effects on major adverse cardiovascular events (MACE), hospitalization for heart failure (HHF), and all-cause mortality (ACM) acros

S Sara J Cromer

Effects of Telerehabilitation With Exercise as the Core Component on Peak Oxygen Uptake and Blood Pressure in Patients With Cardiovascular Disease: Systematic Review and Meta-Analysis

J Med Internet Res. 2026 Sep 21;28:e95923. doi: 10.2196/95923.ABSTRACTBACKGROUND: Cardiovascular disease (CVD) remains the leading global cause of mortality, and exercise-based cardiac rehabilitation improves cardiorespiratory fitness and reduces recurrent events. However, center-based rehabilitatio

Z Zhicheng Zhu

Obstructive Sleep Apnea as a Modifier of Systemic Thromboembolic Risk Following Retinal Vein Occlusion

Retina. 2026 Sep 21. doi: 10.1097/IAE.0000000000005017. Online ahead of print.ABSTRACTBACKGROUND: Systemic vascular risk stratification following retinal vein occlusion (RVO) remains limited. We evaluated whether comorbid obstructive sleep apnea (OSA) modifies thromboembolic risk following RVO.METHO

N Neil Dogra

The Behavior of the External Limiting Membrane and Ellipsoid Zone in Diabetic Macular Edema: A Population AI-Assisted Optical Coherence Tomography Study

Invest Ophthalmol Vis Sci. 2026 Sep 1;67(11):40. doi: 10.1167/iovs.67.11.40.ABSTRACTPURPOSE: To investigate the behavior of the external limiting membrane (ELM) and ellipsoid zone (EZ) in diabetic macular edema (DME) using artificial intelligence (AI)-based optical coherence tomography (OCT) quantif

E Edoardo Midena

Cangrelor in elderly patients undergoing percutaneous coronary intervention: findings from the ICARUS Registry

J Cardiovasc Med (Hagerstown). 2026 Sep 1;27(9):726-734. doi: 10.2459/JCM.0000000000001939. Epub 2026 Aug 27.ABSTRACTBACKGROUND/OBJECTIVES: We aimed to assess the clinical characteristics and in-hospital outcomes of elderly vs. nonelderly patients treated with cangrelor during percutaneous coronary

S Stefano Benenati

Outcomes of SGLT2 inhibitors after transcatheter mitral valve repair in patients with type 2 diabetes mellitus

J Cardiovasc Med (Hagerstown). 2026 Sep 1;27(9):716-725. doi: 10.2459/JCM.0000000000001936. Epub 2026 Aug 27.ABSTRACTBACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2is) have demonstrated cardio- and renoprotective effects in patients with heart failure and type 2 diabetes mellitus (T2DM)

M Mahmoud Abdelnabi

Newer-generation balloon-expandable vs. self-expanding transcatheter aortic valves: a propensity score matched analysis

J Cardiovasc Med (Hagerstown). 2026 Sep 1;27(9):706-715. doi: 10.2459/JCM.0000000000001934. Epub 2026 Aug 27.ABSTRACTAIMS: Balloon-expandable valve (BEV) and self-expanding valve (SEV) platforms have undergone significant technological advancements. This study aimed to compare postoperative outcomes

M Massimo Baudo

Dose-stratified lipid-lowering efficacy and safety of oral PCSK9 inhibitors: a systematic review and meta-analysis

J Cardiovasc Med (Hagerstown). 2026 Sep 1;27(9):688-701. doi: 10.2459/JCM.0000000000001931. Epub 2026 Sep 1.ABSTRACTBACKGROUND: Oral PCSK9 inhibitors are investigational agents that may broaden therapeutic choice beyond injectable PCSK9-targeting therapies, but their efficacy and short-term safety a

M Marcello Marchetta

Loss of arap3 drives a cerebral cavernous malformation-like phenotype in zebrafish via Krit1 interaction and RhoA dysregulation

Development. 2026 Sep 15;153(18):dev205762. doi: 10.1242/dev.205762. Epub 2026 Sep 21.ABSTRACTCerebral cavernous malformations (CCMs) are severe vascular anomalies characterized by abnormal cerebrovascular development, leading to profound structural and functional deficits in the brain. However, the

D Di Yang

Myocardial dysfunction associated with low-dose endotoxin administration in adult horses

J Vet Intern Med. 2026 Sep 1;40(5):aalag205. doi: 10.1093/jvimsj/aalag205.ABSTRACTBACKGROUND: Horses with endotoxemia have variable myocardial function, but little is known about the severity or persistence of myocardial dysfunction (MD).HYPOTHESIS/OBJECTIVES: Horses with experimentally induced endo

E Elizabeth Williams Louie

Physiotherapy implementation and hospitalisation-associated disability according to prehospital functional status in older patients with heart failure: a secondary analysis of a prospective nationwide multicentre registry

Age Ageing. 2026 Sep 4;55(9):afag283. doi: 10.1093/ageing/afag283.ABSTRACTBACKGROUND: Hospitalisation-associated disability (HAD) is common in older patients with heart failure (HF) and associated with adverse outcomes. However, the optimal physiotherapy approach for preventing HAD remains uncertain

N Nobuaki Hamazaki

GLP-1-based treatments and long-term clinical outcomes in MASLD amongst older adults: a retrospective cohort study

Age Ageing. 2026 Sep 4;55(9):afag281. doi: 10.1093/ageing/afag281.ABSTRACTBACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease in older adults, driving hepatic decompensation and cardiovascular mortality. Randomised trial data on

T Tilemachos Koutouratsas

Therapeutic Potential of Thiosemicarbazone Derivative in LPS-Induced Mastitis: Dual Modulation of Inflammatory Response and Blood-Milk Barrier Integrity

J Immunol Res. 2026;2026(1):e7518397. doi: 10.1155/jimr/7518397.ABSTRACTMastitis is a prevalent inflammatory disorder in women, this condition exhibits a particularly elevated prevalence among breastfeeding women, which significantly compromises mammary health and lactation function. This research e

L Ling Guo

Discrepancies in low-value practices across cardiovascular disease prevention guidelines. A narrative review

Eur J Gen Pract. 2026 Dec;32(1):2729221. doi: 10.1080/13814788.2026.2729221. Epub 2026 Sep 21.ABSTRACTBACKGROUND: Low-value practices are interventions that do not provide health benefits due to lack of effectiveness or associated risks that outweigh the potential benefits.OBJECTIVES: The purpose of

C Carlos Brotons

Cardiovascular Disease in Complex Emergencies: A Neglected Burden and Evidence on Public Health Interventions From a Scoping Review

Disaster Med Public Health Prep. 2026 Sep 21;20:e155. doi: 10.1017/dmp.2026.10427.ABSTRACTOBJECTIVE: Cardiovascular diseases are the leading global cause of mortality but remain underaddressed in complex emergencies where health responses focus on infectious diseases and acute care. This scoping rev

A Aida Sotomayor Centeno

Obstetric pharmacoeconomics

Expert Rev Pharmacoecon Outcomes Res. 2026 Sep 21. doi: 10.1080/14737167.2026.2738026. Online ahead of print.ABSTRACTINTRODUCTION: Pharmacoeconomic principles are increasingly shaping modern obstetric pharmacology as maternal therapeutics become more complex, costly, and precision-driven. Rising rat

A Ahizechukwu C Eke

Coronary artery bypass grafting outcomes in patients with prior percutaneous coronary intervention: A retrospective cohort study

Interdiscip Cardiovasc Thorac Surg. 2026 Sep 21:ivag265. doi: 10.1093/icvts/ivag265. Online ahead of print.ABSTRACTOBJECTIVE: The clinical significance of prior percutaneous coronary intervention (PCI) in patients undergoing coronary artery bypass grafting (CABG) remains debated, particularly regard

J Joseph Kletzer

Sphingomyelin as a key negative mediator in atrial fibrillation via lipid profiling analysis and functional identification

Europace. 2026 Sep 21:euag270. doi: 10.1093/europace/euag270. Online ahead of print.ABSTRACTAIMS: Atrial fibrillation (AF) has emerged as one of the most prevalent cardiac arrhythmias globally, with its incidence continuously rising, thereby elevating it to a major public health concern. The heart i

L Linlin Wang

Antihypertensive drug targets and pancreatitis reporting signals: An integrative mendelian randomization and FAERS pharmacovigilance study

Sci Prog. 2026 Jul-Sep;109(3):368504261491552. doi: 10.1177/00368504261491552. Epub 2026 Sep 21.ABSTRACTObjectiveTo investigate whether genetically proxied antihypertensive drug targets are associated with pancreatic exocrine diseases and whether corresponding antihypertensive agents show pancreatit

C Chang-Lei Li

Differential analysis of microbial interaction networks

Brief Bioinform. 2026 Sep 1;27(5):bbag522. doi: 10.1093/bib/bbag522.ABSTRACTMicrobiome studies increasingly indicate that disease-associated shifts cannot be understood from compositional changes alone. The functional architecture of microbial communities-encoded in patterns of association among mic

M Marianna Milano

Potential Protective Effects of Mitochondria-Related Gene EHHADH on Diabetic Cardiomyopathy

Cell Biol Int. 2026 Oct;50(10):e70212. doi: 10.1002/cbin.70212.ABSTRACTDiabetic cardiomyopathy (DCM) induces myocardial lipotoxicity, mitochondria are essential for lipid metabolism. This study explored the role of mitochondria-related gene Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase (EH

H Han Sun

mRNA Therapeutics Beyond Infectious Diseases: Expanding Therapeutic Applications and Future Perspectives

Immun Inflamm Dis. 2026 Sep;14(9):e70511. doi: 10.1002/iid3.70511.ABSTRACTBACKGROUND: Messenger RNA (mRNA) therapeutics have rapidly evolved from experimental nucleic acid constructs into a clinically validated therapeutic platform. Their successful application during the COVID-19 pandemic accelerat

G Gedion Mengistu Dejen

Transcatheter aortic valve-in-valve implantation for failed surgical aortic bioprostheses using the Navitor platform: early outcomes in a consecutive single-center cohort

Cardiol J. 2026;33:e00226072. doi: 10.5603/cj.111703.ABSTRACTINTRODUCTION: Transcatheter heart valve implantation into a failed surgical heart valve (THV-in-SHV) is an established reintervention strategy for degenerated aortic bioprostheses; however, early procedural outcomes, discharge hemodynamics

R Robert Sobczyński