BMC Cardiovasc Disord. 2026 Jan 7. doi: 10.1186/s12872-025-05480-3. Online ahead of print.ABSTRACTBACKGROUND: Low handgrip strength (HGS) predicts cardiovascular disease (CVD) risk, potentially via insulin resistance (IR). The triglyceride-glucose (TyG) index and its combinations with adiposity meas
Alzheimers Dement. 2025 Dec;21 Suppl 2:e106720. doi: 10.1002/alz70856_106720.ABSTRACTBACKGROUND: The presence of ApoE4 allele is known to be the most important genetic risk factor for Late Onset Alzheimer's Disease (LOAD). Hyperhomocysteinemia (HHcy), a cardiovascular risk factor, is also being exte
Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression¹. Previously, the ENCODE consortium mapped biochemical signals across hundreds of cell types and tissues and integrated these data to develop a registry containing 0.9 million human and 300
Acta Pharmacol Sin. 2026 Jan 7. doi: 10.1038/s41401-025-01704-6. Online ahead of print.ABSTRACTThe adult human heart is incapable of regeneration after myocardial infarction (MI) injury. One potential therapeutic strategy is to enhance the proliferation of resident cardiomyocytes (CMs). In this stud
Hypertens Res. 2026 Jan 7. doi: 10.1038/s41440-025-02524-1. Online ahead of print.ABSTRACTElevated blood pressure is frequently observed during cancer treatment with vascular endothelial growth factor inhibitors, reflecting either a treatment-emergent adverse event or pharmacological effect. Appropr
NPJ Metab Health Dis. 2026 Jan 7;4(1):2. doi: 10.1038/s44324-025-00094-x.ABSTRACTAlcoholic beverages have been concerned not only for gastronomic delight but also for certain impacts on health, such as obesity, diabetes, and cardiovascular diseases. In this study, we assessed the bioactive functions
No abstractAppl Psychophysiol Biofeedback. 2026 Jan 7. doi: 10.1007/s10484-025-09765-3. Online ahead of print.NO ABSTRACTPMID:41501316 | DOI:10.1007/s10484-025-09765-3
Drugs. 2026 Jan 7. doi: 10.1007/s40265-025-02272-z. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this meta-analysis was to compare the efficacy of PCSK9 and ANGPTL3 inhibitors in patients with homozygous familial hypercholesterolemia (HoFH).METHODS: We systematically searched selected electro
Nat Commun. 2026 Jan 7. doi: 10.1038/s41467-025-67701-9. Online ahead of print.ABSTRACTGlucagon-like peptide-1 receptor agonists (GLP-1 RAs) were initially approved for type 2 diabetes mellitus. Recent evidence suggests their therapeutic potential in various diseases, though their efficacy and safet
Cell Death Dis. 2026 Jan 7;17(1):7. doi: 10.1038/s41419-025-08256-x.ABSTRACTIschemia-reperfusion injury (IRI) represents a major challenge in liver transplantation, driving acute dysfunction and contributing to long-term allograft rejection. This process triggers a robust inflammatory response, lead
Diabetes Obes Metab. 2026 Jan 7. doi: 10.1111/dom.70448. Online ahead of print.ABSTRACTAIMS: MASLD, defined as a steatotic liver disease in the presence of one or more cardiometabolic risk factors and the absence of harmful alcohol intake, exhibits substantial heterogeneity complicating risk stratif
Zhonghua Yi Xue Za Zhi. 2026 Jan 5;106:18-36. doi: 10.3760/cma.j.cn112137-20250804-01959. Online ahead of print.ABSTRACTPanvascular disease is a systemic condition characterized by atherosclerotic lesions as its common pathological feature. It may present as coronary artery disease, cerebrovascular
J Clin Lipidol. 2025 Dec 14:S1933-2874(25)00539-2. doi: 10.1016/j.jacl.2025.12.007. Online ahead of print.ABSTRACTBACKGROUND: Severe hypertriglyceridemia is a major risk factor for cardiovascular disease and acute pancreatitis, where effective and well-tolerated treatments remain limited. MND-21, a
J Transcult Nurs. 2026 Jan 7:10436596251403542. doi: 10.1177/10436596251403542. Online ahead of print.ABSTRACTINTRODUCTION: Cardiovascular disease is the leading cause of death in the Black population, accounting for over 22% of fatalities. Health equity science aims to explore this for evidence of
Alzheimers Dement. 2025 Dec;21 Suppl 2:e105980. doi: 10.1002/alz70856_105980.ABSTRACTBACKGROUND: Amyloid related imaging abnormalities (ARIA) have emerged as indicators of potentially serious side effects in therapeutics for Alzheimer's disease (AD). Squirrel monkeys (SQMs) are a unique non-human pr
J Inherit Metab Dis. 2026 Jan;49(1):e70132. doi: 10.1002/jimd.70132.ABSTRACTMitochondrial trifunctional protein (TFP) deficiency is an inherited disorder of long-chain fatty acid β-oxidation (FAO). TFP is a heteromeric enzyme composed of two α and two β-subunits. Despite early detection and dietary
BMJ. 2026 Jan 7;392:e086850. doi: 10.1136/bmj-2025-086850.ABSTRACTOBJECTIVE: To assess the efficacy and safety of edaravone dexborneol, a multitarget brain cytoprotectant composed of antioxidant and anti-inflammatory ingredients, in improving functional outcomes among patients with acute ischaemic s
BMJ Case Rep. 2026 Jan 7;19(1):e269028. doi: 10.1136/bcr-2025-269028.ABSTRACTUnilateral absence of pulmonary artery (UAPA) is a rare congenital abnormality that occurs during embryonic development. Isolated UAPA has a prevalence of about 1 in 200 000. The clinical presentation varies based on age, b
BMJ Case Rep. 2026 Jan 7;19(1):e270739. doi: 10.1136/bcr-2025-270739.ABSTRACTCHAPLE syndrome is a recently described genetic disorder characterised by dysregulation of the complement pathway, with the acronym standing for 'CD55 deficiency with complement hyperactivation, angiopathic thrombosis and p
BMJ Case Rep. 2026 Jan 7;19(1):e269207. doi: 10.1136/bcr-2025-269207.ABSTRACTA man in his 80s presented with left hemiparesis and was found to have right internal carotid artery occlusion, and mechanical thrombectomy was successfully performed. An implantable loop recorder implanted 3 years ago show
BMJ Case Rep. 2026 Jan 7;19(1):e267760. doi: 10.1136/bcr-2025-267760.ABSTRACTWe present a rare case of an unmarried woman in her mid-twenties with primary amenorrhoea who was found to have the unusual coexistence of mosaic Turner syndrome (45, XO/46, XX) and Mayer-Rokitansky-Küster-Hauser syndrome w
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2025 Dec;37(12):1125-1132. doi: 10.3760/cma.j.cn121430-20250122-00053.ABSTRACTOBJECTIVE: To analyze the effect of serum magnesium on 90-day all-cause mortality in heart failure patients admitted to the intensive care unit (ICU).METHODS: A retrospective cohort s
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2025 Dec;37(12):1085-1091. doi: 10.3760/cma.j.cn121430-20250707-00644.ABSTRACTOBJECTIVE: To investigate phenotypic classification based on plasma lactate trajectories and its association with 28-day mortality in patients with septic cardiomyopathy (SCM).METHODS
BMJ Open. 2026 Jan 6;16(1):e098988. doi: 10.1136/bmjopen-2025-098988.ABSTRACTINTRODUCTION: Meeting the recommended guidelines for physical activity (PA), sedentary behaviour (SB) and sleep, collectively referred to as 24-hour movement behaviours (24h-MBs), is crucial for type 2 diabetes mellitus (T2
