VACTERL association in a newborn as a product of a twin pregnancy by egg donation

Cir Cir. 2025;93(3):315-319. doi: 10.24875/CIRU.22000128.ABSTRACTVACTERL association is a rare entity in newborns, with high mortality in the first year of life. We present a case of a female newborn, product of a twin pregnancy assisted by egg donation. During reanimation, absence of anal orifice a

F Frederic Velasco-Sandoval

Brainstem cavernous malformations in pediatrics: case report and literature review

Cir Cir. 2025;93(3):328-332. doi: 10.24875/CIRU.22000227.ABSTRACTCavernous malformations have a prevalence of 0.4% to 0.8% in the population. Its symptoms are seizures, headache, and motor and cranial nerve deficits. We present the case of a 10-year-old girl with headache, right hemiparesis, ataxia,

A Antonio Heredia-Gutiérrez

Molecular Mediators of the Cardiac Benefits of Exercise

Circ Res. 2025 Jul 7;137(2):163-183. doi: 10.1161/CIRCRESAHA.125.325762. Epub 2025 Jul 3.ABSTRACTExercise exerts myriad cardiovascular benefits and protects against most forms of cardiovascular disease. While extensive epidemiological evidence supports the clinical benefits of exercise, our understa

S Sumeet A Khetarpal

Exercise in Inherited Cardiomyopathies: Optimizing the Dose-Response Curve

Circ Res. 2025 Jul 7;137(2):316-334. doi: 10.1161/CIRCRESAHA.125.326396. Epub 2025 Jul 3.ABSTRACTExercise is generally considered beneficial for cardiovascular health, but for patients with inherited cardiomyopathies, exercise can be a source of anxiety due to concerns about arrhythmia risk and dise

E Eleanor E Rye

Animal Models of Exercise and Cardiometabolic Disease

Circ Res. 2025 Jul 7;137(2):139-162. doi: 10.1161/CIRCRESAHA.124.325704. Epub 2025 Jul 3.ABSTRACTCardiometabolic diseases, encompassing cardiovascular and metabolic disorders, represent a significant global health challenge, driven in part by the rising prevalence of obesity and type 2 diabetes. Exe

G Gengfu Dong

Epidemiology and Cardiovascular Benefits of Physical Activity and Exercise

Circ Res. 2025 Jul 7;137(2):120-138. doi: 10.1161/CIRCRESAHA.125.325526. Epub 2025 Jul 3.ABSTRACTWhile humans evolved to perform routine endurance activity, recent secular trends in the United States and globally have resulted in a dramatic rise in the amount of time spent inactive in both occupatio

M Michael Y Mi

Physiologic Phenotyping of Responses to Exercise and Activity in Heart Failure

Circ Res. 2025 Jul 7;137(2):290-315. doi: 10.1161/CIRCRESAHA.125.325534. Epub 2025 Jul 3.ABSTRACTSubjective and objective limitations to exercise and activity are hallmarks of heart failure (HF), regardless of underlying ejection fraction (EF). These limitations relate to cardiovascular abnormalitie

G Gregory D Lewis

Exercise Training in Heart Failure: Clinical Benefits and Mechanisms

Circ Res. 2025 Jul 7;137(2):273-289. doi: 10.1161/CIRCRESAHA.124.325533. Epub 2025 Jul 3.ABSTRACTClinical guidelines broadly recommend exercise training for patients with heart failure (HF). This review examines clinical benefits of exercise training across HF subtypes, focusing on clinical trials w

L Louisa A Mounsey