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Cardiovascular disease

Association Between Gestational Blood Pressure Trajectories and Postpartum Normotension Recovery in Hypertensive Disorders: Retrospective Cohort Study

JMIR Public Health Surveill. 2026 Apr 30;12:e89295. doi: 10.2196/89295.ABSTRACTBACKGROUND: Hypertensive disorders of pregnancy (HDP) may cause lasting vascular, cardiac, and renal damage, potentially increasing the risk of postpartum cardiovascular disease.OBJECTIVE: This study aimed to examine the

Z Zhijiang Liang

Glucagon-like Peptide-1 Receptor Agonists and Risk of Nonarteritic Anterior Ischemic Optic Neuropathy: Systematic Review and Meta-Analysis

Neurology. 2026 May 26;106(10):e214864. doi: 10.1212/WNL.0000000000214864. Epub 2026 Apr 30.ABSTRACTBACKGROUND AND OBJECTIVES: Recent observational studies have reported conflicting evidence regarding an association between glucagon-like peptide-1 receptor agonists (GLP-1RAs), particularly semagluti

T Thanansayan Dhivagaran

Association of 24-Hour Blood Pressure Variability With Cognition and Brain MRI Markers of Structural Change in Adults in Mid- to Late-Life

Neurology. 2026 May 26;106(10):e214935. doi: 10.1212/WNL.0000000000214935. Epub 2026 Apr 30.ABSTRACTBACKGROUND AND OBJECTIVES: Blood pressure (BP) fluctuates across the 24-hour period. High 24-hour BP variability (BPV) is associated with cardiovascular disease risk, yet its relevance for brain healt

M Madeline Gibson

Protective effects of 23-valent pneumococcal polysaccharide vaccination against mortality among elder patients with type 2 diabetes mellitus

Diabet Med. 2026 Apr 30:e70341. doi: 10.1111/dme.70341. Online ahead of print.ABSTRACTBACKGROUND: Older adults with type 2 diabetes mellitus are at elevated risk for severe pneumococcal disease, experiencing higher rates of complications and mortality. However, the evidence for the protective benefi

X Xiaoling Peng

Divergent Roles of Skeletal Muscle 11beta-HSD1 in Age-Related and Chronic Kidney Disease-Associated Sarcopenia

Eur J Endocrinol. 2026 Apr 30:lvag075. doi: 10.1093/ejendo/lvag075. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) is associated with increased incidence of sarcopenia and muscle weakness in aging patients. The glucocorticoid activating enzyme11β-hydroxysteroid dehydrogenase

M Michael S Sagmeister

Expert considerations to guide the development and delivery of an exercise intervention in people with type 2 diabetes-related foot ulcer disease

Diabet Med. 2026 Apr 30:e70338. doi: 10.1111/dme.70338. Online ahead of print.ABSTRACTOBJECTIVE: Engaging in exercise presents unique challenges for those with type 2 diabetes (T2D) and diabetes-related foot ulcer disease (DFUD). This brief report describes the development of practical consideration

V Vicki L Johnson

Mineralocorticoid Receptor Antagonists With an Acylurea as a Key Polar Interaction Motif

ChemMedChem. 2026 May 14;21(9):e202501047. doi: 10.1002/cmdc.202501047.ABSTRACTMineralocorticoid receptor (MR) antagonists play a vital role in the management of conditions such as heart failure and hypertension. The recent approval of finerenone for diabetic kidney disease, along with expanding opp

A Anneli Nordqvist

Repurposing piroxicam for antithrombotic and cardiopulmonary protection: Pharmacological rationale and therapeutic potential

Indian J Pharmacol. 2026 May 1;58(3):230-238. doi: 10.4103/ijp.ijp_944_25. Epub 2026 May 1.ABSTRACTBACKGROUND: Recent research indicates that non-steroidal anti-inflammatory drugs may interfere in coagulation process and platelet aggregation. However, the potential of piroxicam in thrombotic and car

W Waseem Khalid

Quantitative Assessment of Myocardial Perfusion in Physiological and Pathological Hypertrophy Using Myocardial Contrast Echocardiography

Clin Cardiol. 2026 May;49(5):e70285. doi: 10.1002/clc.70285.ABSTRACTOBJECTIVE: To quantitatively evaluate myocardial perfusion levels in patients with physiological and pathological myocardial hypertrophy using myocardial contrast echocardiography (MCE), and to investigate the diagnostic value of MC

L Liu Chunyao

Purine metabolic adaptation protects the endothelium from disturbed flow-induced DNA damage and atherosclerosis

Proc Natl Acad Sci U S A. 2026 May 5;123(18):e2526299123. doi: 10.1073/pnas.2526299123. Epub 2026 Apr 30.ABSTRACTDespite effective lipid-lowering therapies, atherosclerosis continues to be a leading cause of death, with considerable residual cardiovascular risk. Atherosclerotic lesions develop prefe

Q Qian Ma

Analysis of adenylate cyclase activity in Japanese children with orthostatic dysregulation

PLoS One. 2026 Apr 30;21(4):e0347431. doi: 10.1371/journal.pone.0347431. eCollection 2026.ABSTRACTThe aim of the study was to clarify the cause of orthostatic dysregulation in Japanese children by analyzing fluctuations in adenylate cyclase activity. Four types of orthostatic dysregulation in Japan

N Nobuyoshi Sugiyama

The 2025 Accra Declaration on Upskilling and Cost- Effective Cardiac Surgery in Africa

Asian Cardiovasc Thorac Ann. 2026 Apr 30:2184923251369134. doi: 10.1177/02184923251369134. Online ahead of print.ABSTRACTThe Pan-African Society for Cardiothoracic Surgery (PASCaTS) organized the 1st Pan-African Cardiothoracic Surgery Summit on 21 to 24 February 2025 in Accra, Ghana. The summit brou

A A Charles Yankah

Review of Hyperkalemia Profile for Mineralocorticoid Receptor Antagonist in Patients with Chronic Kidney Disease and Type 2 Diabetes

Cardiorenal Med. 2026 Apr 30:1-18. doi: 10.1159/000552030. Online ahead of print.ABSTRACTBACKGROUND: Type 2 diabetes (T2D) frequently coexists with chronic kidney disease (CKD), magnifying the risk of both cardiovascular and renal complications. Although therapies targeting the renin-angiotensin-ald

J Jessica B Kendrick

Methodological Shortcomings in a Study of Peripheral Circulatory Complications in Type 2 Diabetes

Endocrinol Diabetes Metab. 2026 May;9(3):e70230. doi: 10.1002/edm2.70230.ABSTRACTINTRODUCTION: This critique examines the methodological quality of a recent study by Shahid et al. on mortality trends related to peripheral circulatory complications in patients with type 2 diabetes mellitus using the

A Ahmar Jan Qureshi

Breaking the cycle of hard-to-heal wounds: the role of autologous whole blood clot therapy

J Wound Care. 2026 May 2;35(5):409-415. doi: 10.12968/jowc.2025.0325. Epub 2026 Apr 30.ABSTRACTHard-to-heal (chronic) wounds pose significant challenges in healthcare due to their prolonged inflammatory phase and impaired healing processes. These wounds, commonly associated with diabetes, vascular i

R Robert J Snyder

Effectiveness of silicone superabsorbent polymer dressings for chronic wound management: a prospective single-arm clinical study

J Wound Care. 2026 May 2;35(5):377-391. doi: 10.12968/jowc.2026.0094. Epub 2026 Apr 17.ABSTRACTOBJECTIVE: This study evaluated the effectiveness of silicone superabsorbent polymer (SAP) dressings in patients with venous leg ulcers (VLUs) and diabetic foot ulcers (DFUs), with emphasis on wound area r

A Agnieszka Lipinska

Multidisciplinary Approaches to Cardiovascular-Kidney-Metabolic Syndrome: Lessons from the Kidney-Heart Service

No abstractKidney360. 2026 Apr 1;7(4):702-704. doi: 10.34067/KID.0000001178. Epub 2026 Apr 30.NO ABSTRACTPMID:42060477 | DOI:10.34067/KID.0000001178

E Emeline Reniers

TCF7L2 promotes abdominal aortic aneurysm through smooth muscle cell-mediated extracellular matrix remodeling

JCI Insight. 2026 Apr 30:e195681. doi: 10.1172/jci.insight.195681. Online ahead of print.ABSTRACTAbdominal aortic aneurysm (AAA) lacks effective pharmacological therapies. Here, we investigate transcription factor 7-like 2 (TCF7L2), a genetic locus associated with both thoracic and abdominal aortic

Y Yongjie Deng

The evolving role of artificial intelligence in optimizing treatment and patient selection in diabetic macular edema

Indian J Ophthalmol. 2026 May 1;74(5):690-697. doi: 10.4103/IJO.IJO_3152_25. Epub 2026 Apr 29.ABSTRACTAnti-vascular endothelial growth factor (anti-VEGF) therapy is the mainstay of management for diabetic macular edema (DME), but marked variability in response, high injection frequency, and cumulati

D Dhanashree Ratra

Anti-vascular endothelial growth factor therapy in clinical practice: Real-world scenarios, limitations, and outcomes

Indian J Ophthalmol. 2026 May 1;74(5):643-652. doi: 10.4103/IJO.IJO_185_26. Epub 2026 Apr 29.ABSTRACTThis narrative review examines the "efficacy-effectiveness gap" in anti-vascular endothelial growth factor (anti-VEGF) therapy by comparing outcomes from randomized controlled trials (RCTs) with glob

D Deepa Sharma

Targeted small molecules in Polymyalgia Rheumatica: the emerging role of jak inhibitors beyond glucocorticoids and DMARDs

Expert Opin Pharmacother. 2026 Apr 30. doi: 10.1080/14656566.2026.2668585. Online ahead of print.ABSTRACTINTRODUCTION: Glucocorticoids remain the cornerstone of therapy for polymyalgia rheumatica (PMR), but their long-term use is associated with substantial toxicity. Glucocorticoid-sparing strategie

M Miguel Ángel Gonzalez-Gay

Audiovisual Augmentation of Electronic Consent to Improve Consent Rates and Comprehension: A Randomized Clinical Trial

JAMA Netw Open. 2026 Apr 1;9(4):e269347. doi: 10.1001/jamanetworkopen.2026.9347.ABSTRACTIMPORTANCE: The use of audiovisual aids in the consent process may improve comprehension and willingness to participate in research. However, data supporting this hypothesis are lacking.OBJECTIVE: To determine th

P Pishoy Gouda

Pregestational Cardiometabolic Biomarkers and Future Hypertensive Disorders of Pregnancy

JAMA Netw Open. 2026 Apr 1;9(4):e2610037. doi: 10.1001/jamanetworkopen.2026.10037.ABSTRACTIMPORTANCE: Hypertensive disorders of pregnancy (HDP) are one of the leading causes of maternal morbidity and death. There is an urgent need to improve early identification of women at risk of HDP, and assessme

A Angelika Qvick

Resistant Starch as a Functional Nutrient to Control Cardiometabolic Risk Factors in Humans: An Integrative Review

Curr Nutr Rep. 2026 Apr 30;15(1):43. doi: 10.1007/s13668-026-00766-0.ABSTRACTPURPOSE OF REVIEW: Resistant starch (RS) has been widely investigated as a dietary component with potential metabolic benefits, including improved insulin sensitivity, lipid profile, and inflammatory markers. However, clini

I Isabela Ribeiro Grangeira Tavares