Development and External Validation of a Machine Learning-Based Risk Classification Score for Prostate Cancer-Specific Cardiovascular Risk

JCO Oncol Pract. 2026 May 29:OP2600131. doi: 10.1200/OP-26-00131. Online ahead of print.ABSTRACTPURPOSE: Patients with prostate cancer (PC) face elevated cardiovascular (CV) risk. Conventional CV risk scores are often poorly calibrated for PC and require laboratory tests that are not routinely avail

N Nickolas Stabellini

Associations of Baseline Clinical Phenotypes With White Matter Hyperintensity Volume Change: A Study of 4,329 UK Biobank Participants

Neurology. 2026 Jun 23;106(12):e218085. doi: 10.1212/WNL.0000000000218085. Epub 2026 May 29.ABSTRACTBACKGROUND AND OBJECTIVES: White matter hyperintensities (WMHs) relate to cognitive and physical impairment. Although WMHs typically progress over time, regression has also been observed. Our aim was

A Angelina Kirilova Kancheva

Ergothioneine exerts neuroprotection in experimental ischemic stroke via activation of PI3K/Akt/Nrf2 pathway

Neuroreport. 2026 Jul 8;37(10):382-392. doi: 10.1097/WNR.0000000000002273. Epub 2026 May 27.ABSTRACTBACKGROUND: Ischemic stroke is a leading cause of serious long-term disability and mortality worldwide. Ergothioneine (EGT), a natural dietary sulfur-containing amino acid, possesses potent antioxidan

X Xizhong Jing

Hyperkalemia and its treatment: real-world evidence and managed care considerations supporting use of potassium binders

Am J Manag Care. 2026 Jun;32(8 Suppl):S143-S154. doi: 10.37765/ajmc.2026.89965.ABSTRACTAn estimated 3.7 million adults in the United States have hyperkalemia. It commonly occurs in patients with chronic kidney disease (CKD) and/or heart failure (HF) and as a result of treatment with renin-angiotensi

E Edgar Lerma

Outcomes of simplified left atrial appendage occlusion using the WATCHMAN FLX device: the ROSE-FLX study

Europace. 2026 May 6;28(5):euag045. doi: 10.1093/europace/euag045.ABSTRACTAIMS: Conventional left atrial appendage occlusion (LAAO) procedures typically require transoesophageal echocardiography and general anaesthesia, which may limit feasibility in resource-limited settings. Simplified LAAO (sLAAO

W Wei Zhou

Transcriptional and chromatin dynamics in macrophage differentiation and activation

Sci Immunol. 2026 May 29;11(119):eaec1740. doi: 10.1126/sciimmunol.aec1740. Epub 2026 May 29.ABSTRACTThe differentiation and functional responses of macrophages are shaped by developmental origin, tissue environment, and local inflammatory cues. These signals converge on transcriptional and chromati

M Marten A Hoeksema

EZH2 inhibition via GSK-126 mitigates EndMT and atherosclerosis in diabetes: A translational epigenetic approach

Sci Adv. 2026 May 29;12(22):eaee5560. doi: 10.1126/sciadv.aee5560. Epub 2026 May 29.ABSTRACTAtherosclerosis drives cardiovascular morbidity in diabetes, with endothelial-to-mesenchymal transition (EndMT) as a key contributor. Whereas epigenetic regulators are increasingly implicated in atherosclerot

M Misbah Aziz

Validation of the Vision Impairment Screening Assessment in acute stroke care: a prospective diagnostic accuracy study

Eur Stroke J. 2026 May 6;11(5):aakag053. doi: 10.1093/esj/aakag053.ABSTRACTINTRODUCTION: Visual abnormalities are common after stroke but are often overlooked in acute care. The Vision Impairment Screening Assessment (VISA) was developed to support non-specialist clinicians in identifying visual abn

S Stephen James Ryan

Hepatic Steatosis: A Pandemic Disease Causing Serious Secondary Diseases

Dtsch Arztebl Int. 2026 Sep 18;123(19):arztebl.m2026.0074. doi: 10.3238/arztebl.m2026.0074. Online ahead of print.ABSTRACTBACKGROUND: At least one-quarter of the world's population now suffers from hepatic steatosis (fatty liver disease), which, in current terminology, is called metabolic dysfunctio

A Ali Canbay

Risk factors for post-induction hypotension in patients with end-stage renal disease undergoing general anesthesia

PLoS One. 2026 May 29;21(5):e0350083. doi: 10.1371/journal.pone.0350083. eCollection 2026.ABSTRACTBACKGROUND: Patients with end-stage renal disease (ESRD) are at highly susceptible to hemodynamic instability during anesthesia induction. However, data specific to this population remain limited.METHOD

S Supachai Trikisayaveach

Pitch as a Shared Code for Music and Speech: Behavioral and Neural Evidence From Stroke Patients

Brain Behav. 2026 Jun;16(6):e71512. doi: 10.1002/brb3.71512.ABSTRACTINTRODUCTION: Accurate pitch processing, including the ability to discriminate small differences in pitch, is essential for interpreting the melodic structure of both music and speech. However, the extent to which pitch discriminati

A Aleksi J Sihvonen

Temporal transcriptomic profiling of pulmonary thromboembolism reveals persistent NETosis- and ferroptosis-associated gene signatures and enhanced thrombolysis with adjunctive DNase I

PLoS One. 2026 May 29;21(5):e0349853. doi: 10.1371/journal.pone.0349853. eCollection 2026.ABSTRACTOBJECTIVE: To investigate the dynamic pathophysiology of pulmonary thromboembolism (PTE), focusing on the roles of neutrophil extracellular traps (NETs) and ferroptosis, and to evaluate intravenous DNas

J Jialun Chen

Multi-omics profiling reveals epidermal growth factor as a potential biomarker and therapeutic target in lupus nephritis and ANCA-associated vasculitis with rapidly progressive glomerulonephritis

PLoS One. 2026 May 29;21(5):e0349307. doi: 10.1371/journal.pone.0349307. eCollection 2026.ABSTRACTThe kidney is a primary target organ in systemic lupus erythematosus (SLE) and ANCA-associated vasculitis (AAV), which frequently manifest as lupus nephritis (LN) and renal AAV, respectively. A severe a

M Mengli Xu

GSEA and the coexpression network approach identify novel pathway connections of molecular processes affected in Porto-sinusoidal vascular disease

PLoS One. 2026 May 29;21(5):e0347338. doi: 10.1371/journal.pone.0347338. eCollection 2026.ABSTRACTBACKGROUND: Porto-sinusoidal vascular disease (PSVD) is a complex, rare liver disease characterized by the absence of cirrhosis, with or without the presence of portal hypertension or histological lesio

A Aishwarya Iyer

Exploring the Causality Between Mood Swings and Neurological Diseases: A Mendelian Randomization Study

Brain Behav. 2026 Jun;16(6):e71506. doi: 10.1002/brb3.71506.ABSTRACTBACKGROUND: Associations between genetically predicted mood swings and neurological diseases have been suggested. However, the causal relationships between these factors remain undefined.METHOD: We used a Mendelian randomization (MR

N Na Li

Differential Therapeutic Modulations of Adiponectin: Beneficial, Adverse, and Context-Dependent Effects in Chronic Coronary Syndromes

Med Princ Pract. 2026 May 29:1-18. doi: 10.1159/000552748. Online ahead of print.ABSTRACTDifferent degrees of chronic metabolic inflammation and adiponectin resistance significantly contribute to the development of cardiovascular diseases and metabolic syndrome. Adiponectin is a unique pleiotropic a

S Sanja Stojanović

Case series evaluating the performance of two superabsorbent dressings combined with cohesive two-layer compression bandages for the treatment of highly exuding venous leg ulcers

Br J Community Nurs. 2026 Jun;31(Sup6):S6-S15. doi: 10.12968/bjcn.2025.0196. Epub 2026 May 29.ABSTRACTBACKGROUND: Venous leg ulcers are highly exuding and require compression, which challenges a dressing to absorb while being compressed.AIMS: This study compares exudate management on venous leg ulce

L Laura E Leitch

Antibiotic-Loaded Polymethyl Methacrylate Cement Drives Fibroblast-Mediated Angiogenesis via LOXL2 to Accelerate Diabetic Foot Ulcer Healing

FASEB J. 2026 Jun 15;40(11):e71881. doi: 10.1096/fj.202600478R.ABSTRACTAntibiotic-loaded polymethylmethacrylate (PMMA) cement (APC) improves healing in diabetic foot ulcers (DFUs), yet the cellular mechanisms underlying its pro-angiogenic effects remain unclear. This study aimed to identify key cell

Y Yueheng Zhang

Statins and risk of cardiovascular disease: Emulating a primary prevention trial in breast cancer survivors

J Natl Cancer Inst. 2026 May 29:djag158. doi: 10.1093/jnci/djag158. Online ahead of print.ABSTRACTBACKGROUND: Limited evidence is available from randomized trials to guide clinical decision-making for cardiovascular disease (CVD) prevention with statins among women with breast cancer. We leveraged r

R Rienna G Russo

Replication and compartmentalization of Dobrava-Belgrade virus in the central nervous system

Emerg Microbes Infect. 2026 Dec;15(1):2673649. doi: 10.1080/22221751.2026.2673649. Epub 2026 May 29.ABSTRACTA heart-transplant recipient developed fatal neurologic disease. High-throughput sequencing (HTS) identified Dobrava - Belgrade virus in central nervous system (CNS) and peripheral specimens.

J Julia Melchert

Evaluating Kidney Responses to Angiotensin-Converting Enzyme Inhibition at the Single-Cell Level

No abstractJ Am Soc Nephrol. 2026 May 29. doi: 10.1681/ASN.0000001144. Online ahead of print.NO ABSTRACTPMID:42213497 | DOI:10.1681/ASN.0000001144

A Abigail C Lay

Pacritinib Impact on QT Interval: Results of a Thorough QT Study and Post Hoc Analysis of Prospective Clinical Trial Data

Clin Pharmacol Drug Dev. 2026 Jun;15(6):e70070. doi: 10.1002/cpdd.70070.ABSTRACTPacritinib, an inhibitor of JAK2/IRAK1/ACVR1 that is devoid of JAK1 activity, approved for treating myelofibrosis in patients with severe thrombocytopenia, carries a label warning for QT interval prolongation. To evaluat

S Sarah A Buckley

Naloxone and Clinical Outcomes in Suspected Opioid-Associated Out-of-Hospital Cardiac Arrests

JAMA Netw Open. 2026 May 1;9(5):e2615539. doi: 10.1001/jamanetworkopen.2026.15539.ABSTRACTIMPORTANCE: Although US opioid overdose deaths have recently declined, mortality remains higher than before the COVID-19 pandemic, and the role of naloxone in opioid-associated out-of-hospital cardiac arrest (O

R Ralph C Wang

Effectiveness of Micronized Purified Flavonoid Fraction on Quality of Life in Patients with Chronic Venous Disease: A Systematic Review and Meta-analysis

Clin Drug Investig. 2026 May 29. doi: 10.1007/s40261-026-01563-x. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVE: Chronic venous disease (CVD) substantially impacts patients' quality of life (QoL) owing to leg symptoms such as pain, swelling, and discomfort. The aim of this meta-analysis was

F Fabricio Rodrigues Santiago