Integrated Assessment of Abdominal Adiposity and Muscle Strength for Atherosclerotic Cardiovascular Disease Risk in UK Biobank: A Comprehensive Analysis From Population Cohort to Multi-Omics Molecular Exploration

Diabetes Obes Metab. 2026 Aug 25. doi: 10.1111/dom.71278. Online ahead of print.ABSTRACTBACKGROUND: Waist circumference (WC) and grip strength (GS) are independently associated with atherosclerotic cardiovascular disease (ASCVD) risk. However, their joint impact remains insufficiently explored. This

J Jie Luo

Evaluating the use of proactive surveillance and remote patient monitoring to guide the timing of valve intervention in patients with severe asymptomatic aortic stenosis (APRAISE-AS): results of a pilot randomised controlled trial

Heart. 2026 Aug 25:heartjnl-2026-327782. doi: 10.1136/heartjnl-2026-327782. Online ahead of print.ABSTRACTBACKGROUND: The insidious nature of aortic stenosis (AS) combined with the advanced age of the affected population results in underreporting of symptoms and underestimation of impact on function

N Nazish Khan

A Contemporary Pathomechanistic Nosology of Inherited Lysosomal Disorders

J Inherit Metab Dis. 2026 Sep;49(5):e70245. doi: 10.1002/jimd.70245.ABSTRACTLysosomal disorders (LDs) have traditionally been defined by intra-lysosomal substrate accumulation resulting from deficiencies of lysosomal enzymes or associated proteins. Advances in lysosomal biology have demonstrated tha

E Eamon P McCarron

The impact of new obesity definitions on prevalence and health outcomes

Diabetes Res Clin Pract. 2026 Aug 25:113522. doi: 10.1016/j.diabres.2026.113522. Online ahead of print.ABSTRACTAIMS: Recently, the European Association for the Study of Obesity (EASO) andLancet Diabetes & Endocrinologyhave proposed new frameworks for diagnosing obesity. This study aimed to examine t

X Xiuqi Qiao