Association of short-term exposure to ozone with total and cause-specific mortality: A systematic review and meta-analysis

Global ozone (O(3)) levels have increased by 30-70 % over the past century, raising growing concerns about their impacts on human health under climate change. However, previous reviews have been regionally limited and lacked standardized exposure metrics or cause-specific analyses. To address these

X Xiaohong Jia

Explainable Logistic Regression for Heart Disease Risk Prediction in Community and Clinical Populations: Development and External Validation Study

JMIR Cardio. 2025 Dec 20. doi: 10.2196/82462. Online ahead of print.ABSTRACTBACKGROUND: Heart disease is a leading cause of morbidity and mortality worldwide. Although machine learning models can achieve strong predictive performance, their limited interpretability hampers clinical adoption. Logisti

P Peihua Tong

Decreased level of consciousness in acute ischemic stroke: risk factors, territories, stroke mechanisms and outcome. A single-centre cohort study

J Neurol. 2025 Dec 21;273(1):35. doi: 10.1007/s00415-025-13548-5.ABSTRACTBACKGROUND: A decreased level of consciousness (DLOC) at onset is infrequent in patients with acute ischemic stroke (AIS). We assessed stroke localization, patient and stroke characteristics, revascularization rates, and long-t

P P Palazzo

Evaluation of the Use of Herbs, Spices, and Supplements in the Hispanic/Latino/Latina Population in Kokomo, Indiana, U.S.A

J Community Health. 2025 Dec 21. doi: 10.1007/s10900-025-01546-7. Online ahead of print.ABSTRACTAlthough the Hispanic/Latino/Latina immigrant population group has been documented to use a higher number of herbs, spices and supplements, research findings on this topic are still insufficient. This stu

K Kim Mossburg

Towards a better definition of left ventricular hypertrophy in Fabry disease: sex-specific thresholds to personalize prognostication

No abstractEur Heart J Cardiovasc Imaging. 2025 Dec 20:jeaf365. doi: 10.1093/ehjci/jeaf365. Online ahead of print.NO ABSTRACTPMID:41422419 | DOI:10.1093/ehjci/jeaf365

I Inês Miranda

Centering Community Engagement in a Hypertension Clinical Trial: Strategies to Engage Rural Black Patients in the Southeastern Collaboration to Improve Blood Pressure Control

J Racial Ethn Health Disparities. 2025 Dec 20. doi: 10.1007/s40615-025-02774-2. Online ahead of print.ABSTRACTBlack Americans residing in rural communities are often excluded from clinical trials for hypertension, despite having a high prevalence of the disease and frequent complications. This repor

S Stephanie Hart

The effect of high-dose long-term therapy of intravenous immunoglobulins in autoimmune autonomic and sensory small fiber neuropathy: a retrospective open-label controlled study

Sci Rep. 2025 Dec 20. doi: 10.1038/s41598-025-33059-7. Online ahead of print.ABSTRACTIntravenous Immunoglobulins (IVIG) are used to treat autoimmune autonomic and sensory small fiber neuropathy (ASFN). The long-term effects of a high immunomodulatory dose of IVIG in ASFN remain unclear. This retrosp

P Peter Novak

Indocyanine green fluorescence-guided perfusion vs. standard assessment to prevent clinical anastomotic leak after colorectal resection: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials with site-specific subgroup analysis

World J Surg Oncol. 2025 Dec 20;23(1):454. doi: 10.1186/s12957-025-04163-9.ABSTRACTBACKGROUND: Anastomotic leak remains a devastating complication after colorectal resection, with an incidence rate of 3-19%, and has profound impacts on morbidity, mortality, and quality of life. Indocyanine green (IC

W Wajahat Mirza

Surgical intervention with cardiopulmonary bypass in a patient with von Willebrand disease

BMC Anesthesiol. 2025 Dec 20. doi: 10.1186/s12871-025-03580-3. Online ahead of print.ABSTRACTBACKGROUND: This article presents a clinical case of surgical intervention with cardiopulmonary bypass (CPB) in a patient with von Willebrand disease (VWD). VWD is the most common inherited bleeding disorder

O O A Loskutov

Integrative transcriptomic and single-cell analysis reveals mitochondrial-related gene biomarkers in heart failure with preserved ejection fraction

Sci Rep. 2025 Dec 20. doi: 10.1038/s41598-025-03926-4. Online ahead of print.ABSTRACTHeart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by impaired diastolic function closely associated with mitochondrial dysfunction. This study aims to identify hub genes rel

H Hongjun You

Sigma1R restores mitochondrial energy metabolism via the IRE1α/XBP1 pathway

Sci Rep. 2025 Dec 20. doi: 10.1038/s41598-025-31500-5. Online ahead of print.ABSTRACTTo investigate the role of Sigma1 receptor (Sigma1R) in mitochondrial energy metabolism remodeling in atrial myocytes, elucidate the associated molecular mechanisms, and evaluate its therapeutic potential in atrial

W Wei Yan

Associations between lifestyle, malnutrition, and health risks in a comprehensive population-based analysis

Sci Rep. 2025 Dec 20. doi: 10.1038/s41598-025-29282-x. Online ahead of print.ABSTRACTObesity, lifestyle factors, and malnutrition increase the risk of cardiovascular events and mortality, however the interplay between lifestyle and malnutrition remains underexplored. We hypothesize that a healthier

M Maxime A Banck

miRquad: first-in-class dPCR multiplex TaqMan™ Advanced clinical research assay for microRNA detection in head and neck cancer

J Exp Clin Cancer Res. 2025 Dec 20. doi: 10.1186/s13046-025-03590-6. Online ahead of print.ABSTRACTBACKGROUND: Cancer resistance is one of the major challenges in oncology, often resulting in disease relapse and poor patient outcomes. Within the RNA family, microRNAs (miRNAs) regulate core biologica

M Matteo Allegretti

Technical and clinical outcomes of endovascular treatment for splenic artery aneurysms

No abstractBMC Surg. 2025 Dec 20. doi: 10.1186/s12893-025-03422-6. Online ahead of print.NO ABSTRACTPMID:41422016 | DOI:10.1186/s12893-025-03422-6

X Xiong Zhang

Exercise in CKM syndrome progression: a stage-specific approach to cardiovascular, metabolic, and renal health

Cardiovasc Diabetol. 2025 Dec 20. doi: 10.1186/s12933-025-03029-4. Online ahead of print.ABSTRACTCardiovascular-Kidney-Metabolic (CKM) syndrome progresses through distinct stages, from early metabolic risk factors to advanced cardiovascular disease and kidney dysfunction. Across these stages, exerci

Z Zacharias Papadakis

Methylglyoxal potentiates palmitic acid-induced endothelial dysfunction and atherogenesis in human endothelial cells

BMC Cardiovasc Disord. 2025 Dec 20. doi: 10.1186/s12872-025-05423-y. Online ahead of print.ABSTRACTBACKGROUND: Endothelial dysfunction is a key pathological mechanism in atherosclerotic cardiovascular disease, and methylglyoxal (MGO) has been identified as a major contributor to endothelial cell dam

B Banafsheh Yalameha

Risk of short telomere as biomarker of diabetes mellitus type 2 status in the CORDIOPREV study

Clin Investig Arterioscler. 2025 Dec 19:500888. doi: 10.1016/j.arteri.2025.500888. Online ahead of print.ABSTRACTBACKGROUND: The presence of type 2 diabetes mellitus (T2DM) in cardiovascular disease (CVD) is associated with poorer clinical outcomes. To identify biomarkers is essential to predict T2D

A Ana Ojeda-Rodriguez

Enhancing Clinical Workflows in Colombia through 3D Technologies: A Focus on Preoperative planning, Education, and Tool design

Acad Radiol. 2025 Dec 19:S1076-6332(25)01118-3. doi: 10.1016/j.acra.2025.11.035. Online ahead of print.ABSTRACTRATIONALE AND OBJECTIVES: This study aims to explore the utility of 3D technologies in a high complexity medical school hospital in Latin America, focusing on three key scenarios: preoperat

C Camilo E Pérez-Cualtán

Evolution of the nomenclature of steatotic liver diseases: Towards a paradigm shift

Rev Med Interne. 2025 Dec 19:S0248-8663(25)01333-5. doi: 10.1016/j.revmed.2025.12.003. Online ahead of print.ABSTRACTMetabolic steatotic diseases affect 16.7% of the French population, i.e. approximately 8 million individuals. Approximately 60% of type 2 diabetes patients have hepatic steatosis, 30%

P Philippe Halfon

SDOH, healthy lifestyle, and life expectancy in adults with CKM syndrome: two cohort studies

Prog Cardiovasc Dis. 2025 Dec 18:S0033-0620(25)00192-6. doi: 10.1016/j.pcad.2025.11.012. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the independent and joint associations of social determinants of health (SDOH) and healthy lifestyle factors with life expectancy among adults with cardiovasc

Q Qiong Huang

Postpartum hemorrhage and short-term risk of cardiovascular disease

Am J Obstet Gynecol. 2025 Dec 18:S0002-9378(25)00938-X. doi: 10.1016/j.ajog.2025.12.041. Online ahead of print.ABSTRACTOBJECTIVE: Postpartum hemorrhage (PPH) is a common obstetrical complication that, in severe cases, may necessitate blood transfusion. We hypothesized that severe PPH, defined as PPH

E Emily E Daggett

Coevolutionary Analysis of Evidence and Recommendations in STEMI Clinical Practice Guidelines: A 33-Year Meta-Research Study of ACC, AHA, and ESC

Am Heart J. 2025 Dec 18:107326. doi: 10.1016/j.ahj.2025.107326. Online ahead of print.ABSTRACTBACKGROUND: ST-Segment Elevation Myocardial Infarction (STEMI) is considered the main cause of mortality and morbidity for decades globally. Regularly, cardiology-related medical organizations publish clini

I Israel Júnior Borges Do Nascimento

Associations of Metabolic Syndrome and Albuminuria with All-Cause Mortality in Patients with Coronary Artery Disease and No History of Diabetes: A Cohort Study

Clin Med (Lond). 2025 Dec 18:100547. doi: 10.1016/j.clinme.2025.100547. Online ahead of print.ABSTRACTBACKGROUND: Metabolic syndrome is a constellation of cardiovascular risk factors and has been associated with a higher risk of mortality. Albuminuria was previously part of the criteria for metaboli

H Harold Henrison C Chiu

Comprehensive machine learning-enabled outcome prediction for patients with coronary artery disease using multi-center patient data

Can J Cardiol. 2025 Dec 18:S0828-282X(25)01589-2. doi: 10.1016/j.cjca.2025.12.024. Online ahead of print.ABSTRACTBACKGROUND: Treatment decision-making for patients with coronary artery disease (CAD) can benefit from accurate patient outcome prediction. While previous studies have employed machine le

E Emma Bogner