Pharmacogenomics and artificial intelligence in cardiovascular disease: emerging tools for precision medicine

Pharmacogenomics. 2026 Sep 14:1-13. doi: 10.1080/14622416.2026.2732154. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) remain a predominant cause of mortality and morbidity globally. Conventional therapy methods may be constrained by their inadequate acknowledgment of individual genetic

S Serap Yalçın Azarkan

Five-Year Follow-Up of Transcatheter Aortic Valve Replacement With Self-Expanding Intra-Annular Versus Commercially Available Valves

JACC Cardiovasc Interv. 2026 Sep 1:S1936-8798(26)01963-1. doi: 10.1016/j.jcin.2026.05.032. Online ahead of print.ABSTRACTBACKGROUND: Long-term outcomes of the self-expanding intra-annular Portico transcatheter aortic valve are not known.OBJECTIVES: This study aimed to report the 5-year outcomes of t

R Raj R Makkar

MSR-ARN: A Multiscale Residual Attentive Deep Learning Framework for Chemical Space-Guided Prediction of Selective MMP-12 Inhibitors

J Chem Inf Model. 2026 Sep 14;66(17):10564-10583. doi: 10.1021/acs.jcim.6c01234.ABSTRACTMatrix metalloproteinase-12, also known as macrophage metalloelastase, plays a critical role in extracellular matrix remodelling and is strongly implicated in various pathological conditions, including cancer, in

I Indrasis Dasgupta

Oxygen, carbon dioxide, and nitric oxide: role in the pathophysiology of obstructive sleep apnea

Med Gas Res. 2027 Jan 1;17(1):285-300. doi: 10.4103/mgr.MEDGASRES-D-25-00224. Epub 2026 Sep 12.ABSTRACTObstructive sleep apnea is a prevalent sleep-related breathing disorder with recurrent episodes of upper airway collapse during sleep, leading to cyclic blood gas fluctuations. Oxygen, carbon dioxi

A Antonio Fabozzi

Medical gases and hypertensive disorders of pregnancy: therapeutic mechanisms and research advances

Med Gas Res. 2027 Jan 1;17(1):242-250. doi: 10.4103/mgr.MEDGASRES-D-26-00014. Epub 2026 Sep 12.ABSTRACTHypertensive disorders during pregnancy pose a serious threat to the health of both mothers and infants, yet the range of available clinical treatments is limited. This review summarizes the mechan

Z Zhiguang Xu

Nitric oxide in the occurrence and development of ischemic cerebrovascular disease

Med Gas Res. 2027 Jan 1;17(1):95-105. doi: 10.4103/mgr.MEDGASRES-D-25-00117. Epub 2026 Sep 12.ABSTRACTSince nitric oxide is a chemically highly reactive free radical that can act as both an oxidizing agent and a reducing agent, it is assumed that it has diverse effects on biological tissues. Nitric

T Tatiana K Bogodvid

Hydrogen therapy and cardiovascular diseases: a visualization analysis of research hotspots and application prospects

Med Gas Res. 2027 Jan 1;17(1):40-45. doi: 10.4103/mgr.MEDGASRES-D-25-00165. Epub 2026 Sep 12.ABSTRACTJOURNAL/mgres/04.03/01612956-202701000-00006/figure1/v/2026-09-13T085902Z/r/image-tiff Hydrogen, an emerging medical gas, has demonstrated diverse biological effects, including anti-oxidant, anti-inf

Y Yi Qian

HydroMg attenuates doxorubicin-induced myocardial injury via promoting mitochondrial function

Med Gas Res. 2027 Jan 1;17(1):30-39. doi: 10.4103/mgr.MEDGASRES-D-25-00179. Epub 2026 Sep 12.ABSTRACTJOURNAL/mgres/04.03/01612956-202701000-00005/figure1/v/2026-09-13T085902Z/r/image-tiff In contrast to molecular hydrogen's intrinsic limitations, HydroMg's structural optimization shortens gastrointe

L Lu Zhang

Development and validation of a machine learning-based predictive model for prognosis in cerebral hemorrhage patients after hyperbaric oxygen therapy

Med Gas Res. 2027 Jan 1;17(1):15-21. doi: 10.4103/mgr.MEDGASRES-D-25-00168. Epub 2026 Sep 12.ABSTRACTJOURNAL/mgres/04.03/01612956-202701000-00003/figure1/v/2026-09-13T085902Z/r/image-tiff Intracerebral hemorrhage is a common and critical neurological emergency, and the inconsistent results of hyperb

C Congyi Ding

Ambient particulate matter pollution and stroke burden

Med Gas Res. 2027 Jan 1;17(1):7-14. doi: 10.4103/mgr.MEDGASRES-D-25-00188. Epub 2026 Sep 12.ABSTRACTJOURNAL/mgres/04.03/01612956-202701000-00002/figure1/v/2026-09-13T085902Z/r/image-tiff As a major component of air pollution, ambient particulate matter pollution has rarely been studied with respect

L Lu Jiang

Variable Expressivity in Long QT Syndrome Type 2 Rabbits Defines a Low Threshold for Therapeutic IKr Restoration

Am J Physiol Heart Circ Physiol. 2026 Sep 14. doi: 10.1152/ajpheart.00154.2026. Online ahead of print.ABSTRACTLong QT syndrome type 2 (LQT2) is caused by pathogenic variants in the hERG potassium channel, resulting in QT prolongation, polymorphic ventricular tachycardia (pVT), and sudden cardiac dea

N Nilufer N Turan

In-hospital outcomes of acute myocardial infarction in Asian Pacific Islanders in the United States over the past two decades: a propensity score-matched analysis

Proc (Bayl Univ Med Cent). 2026 Sep 14:1-10. doi: 10.1080/08998280.2026.2717838. Online ahead of print.ABSTRACTBACKGROUND: Asian Pacific Islanders (APIs) represent one of the fastest-growing racial and ethnic groups in the United States. Yet, national data on temporal trends and in-hospital outcomes

M Maninder Randhawa

Pulsed Field Ablation for Perimitral Atrial Flutter With Involvement of the Vein of Marshall: A Case Report

Pacing Clin Electrophysiol. 2026 Sep 14. doi: 10.1111/pace.70419. Online ahead of print.ABSTRACTBACKGROUND: Perimitral atrial flutter (PMF) involving the vein of Marshall (VOM) remains a therapeutic challenge. The role of pulsed field ablation (PFA) in the treatment of PMF is unclear.CASE PRESENTATI

C Chenghong Bao

Integrated metagenomic and metabolomic analysis identifies severity-specific inflammatory and metabolic signatures in post-stroke depression

Gut Microbes. 2026 Dec 31;18(1):2726620. doi: 10.1080/19490976.2026.2726620. Epub 2026 Sep 14.ABSTRACTPost-stroke depression (PSD) is a common complication that significantly impacts patient prognosis. This study aimed to systematically characterize the associations among gut microbial ecology, meta

W Wenyi Chen

Rethinking Rheumatic Fever Diagnosis: Progress, Pitfalls and the Path Towards a Definitive Test

Med J Aust. 2026 Sep;224(9):e70296. doi: 10.5694/mja2.70296.ABSTRACTElimination of rheumatic heart disease (RHD) as a public health problem requires a multifaceted approach, including better primordial and primary prevention and early case detection and treatment of rheumatic fever, the autoimmune p

A Anna P Ralph

A trial emulation study indirectly comparing tafamidis and acoramidis in transthyretin amyloid cardiomyopathy: the ReplicATTR study

J Comp Eff Res. 2026 Sep 14:e260114. doi: 10.57264/cer-2026-0114. Online ahead of print.ABSTRACTAim: Tafamidis and acoramidis are transthyretin stabilizers approved for the treatment of transthyretin amyloid cardiomyopathy. We compared the effectiveness of acoramidis versus tafamidis regarding all-c

P Philippe Debonnaire

Relations of Menopause Timing With Pressure Pulsatility in the Framingham Study

Hypertension. 2026 Sep 14. doi: 10.1161/HYPERTENSIONAHA.126.27015. Online ahead of print.ABSTRACTBACKGROUND: Women have lower pulse pressure (PP) than men as young adults, but higher PP after a midlife PP nadir. This PP reversal is often attributed to lower estrogen levels at menopause. However, a d

A Amy Y Habib

A Rare Case of Fulminant Myocarditis Caused by Epstein-Barr Virus Infection in a Middle-Aged Man

Clin Lab. 2026 Sep 1;72(9):2003-2006. doi: 10.7754/Clin.Lab.2025.250931.ABSTRACTBACKGROUND: Fulminant myocarditis (FM) is a highly lethal syndrome of abrupt, diffuse cardiac inflammation that precipitates rapid-onset hemodynamic collapse. FM caused by Epstein-Barr virus (EBV) is rare and infrequentl

W Wenjing Yu

Myeloid Dendritic Cell Counts and Coronary Heart Disease: a Bidirectional Mendelian Randomization Study

Clin Lab. 2026 Sep 1;72(9):1858-1870. doi: 10.7754/Clin.Lab.2026.260615.ABSTRACTBACKGROUND: Coronary heart disease (CHD) remains a leading cause of morbidity and mortality worldwide, with immune and inflammatory mechanisms playing important roles in its pathogenesis. Dendritic cells (DCs) are key re

F Feng Lv

Integrated Transcriptomic and Proteomic Analysis Elucidates the Mechanisms of Huperzine A Injection Against Cerebral Ischemia/Reperfusion Injury

Drug Des Devel Ther. 2026 Sep 9;20:627785. doi: 10.2147/DDDT.S627785. eCollection 2026.ABSTRACTBACKGROUND: After recanalization in acute ischemic stroke, cerebral ischemia/reperfusion injury (CI/RI) drives a cascade of pathophysiological events that worsen clinical outcomes, yet effective therapeuti

Y Yule Wang

Cardiovascular and Metabolic Outcomes of Hormone Replacement Therapy in Women Aged 65 Years and Older: A Systematic Review of Randomized Clinical Trials

Clin Pharmacol. 2026 Sep 9;18:581397. doi: 10.2147/CPAA.S581397. eCollection 2026.ABSTRACTBACKGROUND: The cardiovascular, kidney, and metabolic effects of hormone replacement therapy (HRT) in postmenopausal women, particularly those who initiate treatment after age 65, remain incompletely characteri

T Taraneh Mousavi

Mean Platelet Volume and Mean Platelet Volume-to-Platelet Ratio and Their Association With Mortality in Patients Undergoing Maintenance Hemodialysis

Cureus. 2026 Aug 14;18(8):e114527. doi: 10.7759/cureus.114527. eCollection 2026 Aug.ABSTRACTIntroduction Patients receiving maintenance hemodialysis (HD) remain at high risk of cardiovascular morbidity and mortality despite advances in dialysis therapy. The mean platelet volume (MPV) reflects platel

D Diana D Nenova

Immune senescence and exhaustion in breast cancer patients with a history of childhood maltreatment

Brain Behav Immun Health. 2026 Aug 31;56:101345. doi: 10.1016/j.bbih.2026.101345. eCollection 2026 Oct.ABSTRACTPURPOSE: Child maltreatment has lasting adverse effects on both physical and mental health and is associated with reduced quality of life. In Colombia, this problem remains highly prevalent

I Ivon Johanna Rodríguez-Rodríguez

Autoimmune-associated thrombosis: mechanisms, population burden, and prevention strategies

Lancet Reg Health Eur. 2026 Sep 3;70:101850. doi: 10.1016/j.lanepe.2026.101850. eCollection 2026 Nov.ABSTRACTAutoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, and systemic vasculitis, are associated with increased risk of thrombosis, accele

D Deepa J Arachchillage