Intra-aortic adrenaline titration during cardiac arrest

Scand J Trauma Resusc Emerg Med. 2026 Apr 15;34(1):71. doi: 10.1186/s13049-026-01609-1.ABSTRACTAdrenaline has been the principal vasoactive drug in cardiac arrest for decades. It reliably increases return of spontaneous circulation but has not shown a consistent improvement in long-term survival wit

J James E Manning

''Sugar for the Heart'', a bitter pill for tenecteplase: the crystallisation trap of pre-hospital fibrinolysis

Scand J Trauma Resusc Emerg Med. 2026 Apr 15;34(1):73. doi: 10.1186/s13049-026-01594-5.ABSTRACTBACKGROUND: Recent evidence suggests that empiric prehospital administration of tenecteplase in out-of-hospital cardiac arrest is associated with decreased survival and lower rates of return of spontaneous

T Thibaut Prevautel

Percutaneous Interventions for Heart Failure in Congenital Heart Disease

No abstractCurr Cardiol Rep. 2026 Apr 16;28(1):49. doi: 10.1007/s11886-026-02371-7.NO ABSTRACTPMID:41986767 | DOI:10.1007/s11886-026-02371-7

L Lore Schrutka

Global position statement supporting a World Health Assembly resolution on steatotic liver disease

No abstractNat Rev Gastroenterol Hepatol. 2026 Apr 15. doi: 10.1038/s41575-026-01201-z. Online ahead of print.NO ABSTRACTPMID:41986753 | DOI:10.1038/s41575-026-01201-z

J Jeffrey V Lazarus

An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration

Nat Med. 2026 Apr 15. doi: 10.1038/s41591-026-04341-6. Online ahead of print.ABSTRACTBiomarkers to determine underlying frontotemporal lobar degeneration (FTLD) tau or TAR DNA-binding protein (TDP) pathology during life are needed to advance clinical trials targeting specific FTD pathologies. For th

M Madison I J Honey

Cardiac biomarkers in women with high-risk pregnancies: short-term outcomes from the Heidelberg Cardio-Obstetrics Registry

Clin Res Cardiol. 2026 Apr 15. doi: 10.1007/s00392-026-02920-8. Online ahead of print.ABSTRACTBACKGROUND: Pregnancy leads to profound physiological changes within the cardiovascular system. However, in women with pre-existing or pregnancy-associated cardiovascular disease (CVD) these adaptations may

D Deborah Siry

Association between biological aging and clinical mortality among patients with rheumatoid arthritis

Clin Rheumatol. 2026 Apr 15. doi: 10.1007/s10067-026-08110-1. Online ahead of print.ABSTRACTBACKGROUND: Biological aging constitutes a well-recognized risk factor for age-associated diseases; nevertheless, its specific impact on individuals with rheumatoid arthritis (RA) has not been comprehensively

X Xi Zheng

Pitavastatin use and reduced risk of gout: a nationwide propensity score-matched cohort study

Clin Rheumatol. 2026 Apr 15. doi: 10.1007/s10067-026-08127-6. Online ahead of print.ABSTRACTINTRODUCTION: Statins are widely prescribed for lipid management and cardiovascular prevention, but their effects on gout risk remain unclear. Pitavastatin has distinct metabolic and anti-inflammatory propert

C Chih-Hau Hsiao

Predicting post-stroke functional outcome using explainable machine learning and integrated data

Sci Rep. 2026 Apr 15;16(1):12462. doi: 10.1038/s41598-026-47814-x.ABSTRACTFunctional outcome after acute ischemic stroke (AIS) varies widely, and existing prognostic scores may not capture complex relationships. We evaluated a diverse set of clinical characteristics and blood biomarkers with multipl

J Jesper Olsson

Metabolite and nutrient regulation of macrophages in obesity and metabolic disease

Nat Rev Immunol. 2026 Apr 15. doi: 10.1038/s41577-026-01292-4. Online ahead of print.ABSTRACTTissue-resident macrophages are crucial sentinel cells of the innate immune system that sense nutrient fluctuations and orchestrate adaptive responses to support steady-state metabolic homeostasis. When dysr

N Neil T Sprenkle

Endoplasmic reticulum stress in disease pathogenesis: its implications for therapy

Signal Transduct Target Ther. 2026 Apr 16;11(1):136. doi: 10.1038/s41392-026-02600-z.ABSTRACTEndoplasmic reticulum (ER) stress is a key cellular mechanism that is important in the development of many diseases, including cancer. Since the discovery of the unfolded protein response (UPR), research has

S Siyu Wei

Non-infectious environmental risk factors of multiple sclerosis: Mechanisms and intervention windows for prevention

Rev Neurol (Paris). 2026 Apr 14:S0035-3787(26)00504-7. doi: 10.1016/j.neurol.2026.03.010. Online ahead of print.ABSTRACTThe trajectory of multiple sclerosis (MS) is shaped by complex interactions between genetic susceptibility and environmental factors. This review examines modifiable non-infectious

M M Rival

Evaluation of a posteriori dietary pattern methods in cardiovascular disease: a systematic review

Nutrition. 2026 Mar 12;148:113202. doi: 10.1016/j.nut.2026.113202. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular disease (CVD) is a leading global cause of mortality, strongly influenced by diet. Research in this field has evolved from the analysis of nutrients to the evaluation of dietar

M Mónica Lavinia Popescu

The self-efficacy perception in cardiovascular patients: A cohort study on self-care management

J Psychosom Res. 2026 Apr 13;207:112675. doi: 10.1016/j.jpsychores.2026.112675. Online ahead of print.ABSTRACTOBJECTIVE: The international cardiovascular guidelines emphasise self-care as a key factor for better health management in patients. Self-care incorporated into patient engagement is conside

D Dina Di Giacomo

Sex Hormone Influences on Venous Thrombotic and Cardiovascular Risk

N Engl J Med. 2026 Apr 16;394(15):1514-1528. doi: 10.1056/NEJMra2202438.ABSTRACTThrombosis is a recognized complication of sex hormone therapy, which includes hormone replacement for deficiencies, contraceptive therapy, treatment of heavy menstrual bleeding, gender-affirming hormone therapy, suppres

L Leslie Skeith

Randomized Trial of Adjunctive Prednisolone for Kawasaki Disease

N Engl J Med. 2026 Apr 16;394(15):1480-1490. doi: 10.1056/NEJMoa2511478.ABSTRACTBACKGROUND: The effect of adjunctive glucocorticoids in the primary treatment of Kawasaki disease in unselected patients remains unknown.METHODS: In this multicenter, open-label, randomized, controlled trial in China, we

S Siyuan Lin

Asundexian for Secondary Stroke Prevention

N Engl J Med. 2026 Apr 16;394(15):1467-1479. doi: 10.1056/NEJMoa2513880.ABSTRACTBACKGROUND: Patients with noncardioembolic ischemic stroke or transient ischemic attack (TIA) are at risk for recurrent stroke. Low factor XI levels are associated with a reduced risk of ischemic stroke. Asundexian inhib

M Mukul Sharma

Antidiabetic Drug Associations With Heart Failure Outcomes: Real-World Evidence Study Using Electronic Health Records

JMIR Diabetes. 2026 Apr 15;11:e85083. doi: 10.2196/85083.ABSTRACTBACKGROUND: Patients with type 2 diabetes mellitus (T2D) have a higher risk of cardiovascular disease, including heart failure (HF), leading to health care burden including hospitalization and mortality. Among multiple T2D therapies, t

E Elzbieta Jodlowska-Siewert

Automated Identification of Cardiopulmonary Disease Cases for Preoperative Risk Stratification Using Machine Learning: A Retrospective Analysis

A A Pract. 2026 Apr 15;20(4):e02183. doi: 10.1213/XAA.0000000000002183. eCollection 2026 Apr 1.ABSTRACTBACKGROUND: Preoperative chart review is time-consuming and prone to errors, particularly for cardiopulmonary conditions that impact anesthetic planning. We developed a guideline-aligned "clinical

I Ishan Aggarwal

Genetic Association of the Renin-Angiotensin-Aldosterone System with hypertension among the Malays and their adaptation to climate change

PLoS One. 2026 Apr 15;21(4):e0346614. doi: 10.1371/journal.pone.0346614. eCollection 2026.ABSTRACTHypertension (HT) is a 'by-product' to the forces of natural selection against environmental drift and salt availability, therefore contributed to differential HT susceptibility. This study provides fur

N Nur Hasnah Maamor

Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology

Sci Transl Med. 2026 Apr 15;18(845):eadz7727. doi: 10.1126/scitranslmed.adz7727. Epub 2026 Apr 15.ABSTRACTA well-recognized attribute of several common and standard cancer therapeutics is the development of cardiotoxicity. Although many anticancer agents appear to target a relatively select and dist

M Maria Areli Lorenzana-Carrillo

Validating the 2-minute walk test MCID for subacute stroke patients: A Pakistani multicenter cohort analysis

PLoS One. 2026 Apr 15;21(4):e0347056. doi: 10.1371/journal.pone.0347056. eCollection 2026.ABSTRACTBACKGROUND: The 2-Minute Walk Test (2MWT) is a simple and reliable test used by clinicians to evaluate mobility gains in stroke populations.OBJECTIVE: To determine the minimally clinically important dif

M Muslim Khan

Bayesian hierarchical models for multivariate mixed responses with repeated measures: A case study in arterial occlusive disease

PLoS One. 2026 Apr 15;21(4):e0346331. doi: 10.1371/journal.pone.0346331. eCollection 2026.ABSTRACTModeling repeated measures of arterial occlusive diseases, such as peripheral artery disease (PAD), using data with mixed-type outcomes poses unique challenges due to complex dependency structures and d

E Endris Assen Ebrahim

PPP1R3G-RIPK1-ZBP1 axis activates early-stage apoptosis and late-stage necroptosis to promote doxorubicin-induced cardiotoxicity

Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2603301123. doi: 10.1073/pnas.2603301123. Epub 2026 Apr 15.ABSTRACTCardiotoxicity is a dose-limiting complication of doxorubicin (DOX) chemotherapy, yet the molecular mechanisms governing the transition from acute stress to terminal heart failure remain

X Xueling Ma