International Collaboration in Primary Ciliary Dyskinesia

Pediatr Pulmonol. 2026 Nov;61(11):e71888. doi: 10.1002/ppul.71888.ABSTRACTPrimary Ciliary Dyskinesia (PCD) exemplifies how international collaboration can transform the study of a rare disease. Since the identification of the first PCD-associated genes in 1999-2002, parallel developments in Europe a

P Petra Pennekamp

Immediate drug hypersensitivity severity is associated with cardiovascular risk

Allergy Asthma Proc. 2026 Nov 1;47(6):421-428. doi: 10.2500/aap.2026.47.260062.ABSTRACTBackground: Drug hypersensitivity reactions (DHR) exhibit substantial clinical heterogeneity. Although established cardiovascular disease is a known risk factor for severe anaphylaxis, the impact of subclinical ca

A Aysu Okumus Guclu

Alzheimer's disease genetics converges on microglial and neuronal dysregulation

Alzheimer's disease (AD) is the most common cause of dementia, with global case numbers projected to reach 153 million in 2050¹. AD is highly heritable, with twin-based heritability estimates of 60-80%². Although 1,200 causal loci are predicted to exist for AD³, approximately 80 loci have been assoc

E Emil Uffelmann

Tandem repeat variation shapes immune cell type-specific gene expression

Nature. 2026 Oct 28. doi: 10.1038/s41586-026-10438-2. Online ahead of print.ABSTRACTTandem repeats (TRs)-highly polymorphic, repetitive sequences across the human genome-are important regulators of gene expression but remain underexplored due to challenges in accurate genotyping and analysis1. Here

H Hope A Tanudisastro