CYP17A1 Locus: Regulatory Mechanisms and Clinical Associations With Cardiovascular Disease and Metabolic Syndrome

IUBMB Life. 2026 Apr;78(4):e70096. doi: 10.1002/iub.70096.ABSTRACTThe CYP17A1 gene encodes the P450 17α-hydroxylase/17,20-lyase protein, a key enzyme in steroidogenesis. In the past, it was associated with disorders such as congenital adrenal hyperplasia, disorders of sex development, and castration

Y Yasmine Chakkor

Exercise‑induced extracellular vesicle microRNA regulates physiological function (Review)

Mol Med Rep. 2026 Jun;33(6):161. doi: 10.3892/mmr.2026.13871. Epub 2026 Apr 3.ABSTRACTPhysical exercise is essential for maintaining health and preventing disease. Various forms of exercise enhance physiological function by regulating multiple body systems, including the metabolic, immune, cardiovas

Z Zhonglei Wang

Current research progress on extracellular vesicles derived from mesenchymal stem cells in tuberculosis treatment (Review)

Mol Med Rep. 2026 Jun;33(6):163. doi: 10.3892/mmr.2026.13873. Epub 2026 Apr 3.ABSTRACTMesenchymal stem cell‑derived extracellular vesicles (MSC‑EVs) have garnered research attention due to their unique biological functionalities and therapeutic potential. Compared with the parent MSCs from which the

D Dejun Fan

Uremic toxin p‑cresyl sulfate enhances the calcification of aortic valvular interstitial cells via klotho/sirtuin‑1 signaling

Mol Med Rep. 2026 Jun;33(6):162. doi: 10.3892/mmr.2026.13872. Epub 2026 Apr 3.ABSTRACTCalcific aortic valve disease (CAVD), a valvular heart disease with severe complications, is common in patients with chronic kidney disease (CKD). P‑cresyl sulfate (PCS) is a protein‑binding uremic toxin that induc

S Shao-Jung Li

VSNL1 attenuates hypoxia‑induced myocardial apoptosis by regulating the CNP/NPRB pathway

Mol Med Rep. 2026 May;33(5):153. doi: 10.3892/mmr.2026.13863. Epub 2026 Apr 3.ABSTRACTMyocardial apoptosis is a key contributor to the pathogenesis of cardiovascular diseases, driving cardiac dysfunction and disease progression. Visinin‑like protein 1 (VSNL1), a protein involved in cardiac pacing an

X Xing Yang

Influencing Factors and Prediction of Complications After Implantation of Cardiac Electronic Devices

Pacing Clin Electrophysiol. 2026 Apr 3. doi: 10.1111/pace.70228. Online ahead of print.ABSTRACTBACKGROUND: Cardiac implantable electronic device (CIED) related complications occur frequently. Given the uncertainties, a comprehensive investigation of predictive factors is crucial. This study aimed to

C Chuan-Jiang Chen

Beyond oxygen transport: red blood cells as emerging players in mediating endothelial dysfunction in diabetes

Ann Med. 2026 Dec;58(1):2650021. doi: 10.1080/07853890.2026.2650021. Epub 2026 Apr 3.ABSTRACTBACKGROUND: Endothelial dysfunction, a hallmark of diabetic vascular complications, is thought to arise from hyperglycemia-induced oxidative stress and inflammation within endothelial cells. However, accumul

A Ahmed Hassanein

The molecular mechanism of metformin-adipose mesenchymal stem cell derived exosome complex in regulating macrophage polarization to ameliorate liver ischemia-reperfusion injury

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2026 Mar;42(3):210-220.ABSTRACTObjective This study aimed to investigate the protective effect of a metformin (Met)-adipose-derived mesenchymal stem cell exosome (ADSC-Exo) complex (Met-Exo) against hepatic ischemia-reperfusion injury (IRI) and to determine wheth

A Aiwen Jiang

Microsurgical treatment of cerebral arteriovenous malformations: a 20-year experience of the Burdenko Neurosurgical Center

Zh Vopr Neirokhir Im N N Burdenko. 2026;90(2):6-14. doi: 10.17116/neiro2026900216.ABSTRACTOBJECTIVE: To evaluate the results of microsurgical treatment of cerebral arteriovenous malformations (AVMs) over a 20-year period and their dynamics taking into account clinical and morphological characteristi

S Sh Sh Eliava

Temporal trends in second primary malignancies among long-term survivors of multiple myeloma across treatment eras: a population-based analysis of the SEER database

Hematology. 2026 Dec 31;31(1):2653404. doi: 10.1080/16078454.2026.2653404. Epub 2026 Apr 3.ABSTRACTOBJECTIVE: To evaluate temporal trends in second primary malignancy (SPM) risk among long-term multiple myeloma (MM) survivors across treatment eras.METHODS: This retrospective cohort study utilized th

L Liling Lu

Physicians' Awareness and Knowledge of Barriers to Medication Adherence in Cardiovascular Patients and Strategies Employed in Clinical Practice in Saudi Arabia: A Cross-Sectional Study

Inquiry. 2026 Jan-Dec;63:469580261427422. doi: 10.1177/00469580261427422. Epub 2026 Apr 3.ABSTRACTImproving medication adherence can reduce the burden of cardiovascular disease (CVD) in Saudi Arabia and its related healthcare expenses. This study aimed to assess physicians' awareness and knowledge o

A Ahmed R Gardouh

Loss of Y Chromosome Associates With Lung and Cardiac Dysfunction in COPD

Compr Physiol. 2026 Apr;16(2):e70142. doi: 10.1002/cph4.70142.ABSTRACTThis study highlights the previously unknown association of mosaic loss of the Y chromosome to impaired gas exchange and cardiac dysfunction, implicating mosaicism in immune-mediated, multi-organ decline and revealing a mechanisti

C Chanil Valasarajan

Post-Catheter Ablation Long-Term Antithrombotic Strategies in Atrial Fibrillation: A Network Meta-Analysis of Randomized Controlled Trials

Circ Arrhythm Electrophysiol. 2026 Apr 3:e014692. doi: 10.1161/CIRCEP.125.014692. Online ahead of print.ABSTRACTBACKGROUND: Catheter ablation for atrial fibrillation is a widely used rhythm-control strategy, yet its role in reducing thromboembolic risk and enabling oral anticoagulation (OAC) discont

J Juan F Rodriguez-Riascos

Heterogeneity of Treatment Effect for Intra-Aortic Balloon Pump Use Across Lactate Trajectories in Cardiogenic Shock Patients Supported by VA-ECMO: An Analysis of the Chinese Extracorporeal Life Support Registry

MedComm (2020). 2026 Mar 18;7(4):e70698. doi: 10.1002/mco2.70698. eCollection 2026 Apr.ABSTRACTThis study aimed to investigate the heterogeneity of treatment effect for intra-aortic balloon pump (IABP) across various lactate trajectories in patients with acute myocardial infarction-related cardiogen

X Xiang-Jie Duan

Spatially Characterized Aortic Proteome Reveals Novel Regional Signatures and Glucocorticoid Receptor/Dipeptidase 1 Axis in Diabetic Vasculopathy

MedComm (2020). 2026 Mar 30;7(4):e70714. doi: 10.1002/mco2.70714. eCollection 2026 Apr.ABSTRACTDiabetes mellitus poses a major global health burden and is intricately linked to cardiovascular complications, yet the spatial molecular landscape of diabetic vasculopathy remains poorly defined. Since th

C Chak Kwong Cheng

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm (2020). 2026 Mar 19;7(4):e70667. doi: 10.1002/mco2.70667. eCollection 2026 Apr.ABSTRACTExtracellular and membrane proteins serve important roles. They manage cellular communication, structure support, and immune defense. When they malfunction, it cause many diseases like cancer, neurodegener

M Mengqing Zhao

Preconception One-Carbon Metabolism Nutrient Levels in Preparing for Pregnancy Couples and Spontaneous Pregnancy Loss: A Prospective Cohort Study

MedComm (2020). 2026 Mar 30;7(4):e70711. doi: 10.1002/mco2.70711. eCollection 2026 Apr.ABSTRACTSpontaneous pregnancy loss (SPL) remains an important yet poorly understood pregnancy outcome. One-carbon metabolism (OCM) nutrients play an essential role in embryonic development, but their relationship

X Xiaotian Chen

Myocardial infarction with non-obstructive coronary arteries in a patient undergoing nephrectomy under general anesthesia

J Anesth Transl Med. 2025 May 24;4(2):50-54. doi: 10.1016/j.jatmed.2025.03.003. eCollection 2025 Jun.ABSTRACTBACKGROUND: Myocardial infarction with non-obstructive coronary arteries (MINOCA) is an uncommon but clinically significant condition, particularly during the perioperative period. Its diagno

X Xi Fang

Recent Advances in Radiopharmaceuticals for Cancer Diagnosis and Therapy

Oncol Res. 2026 Mar 23;34(4):7. doi: 10.32604/or.2026.075923. eCollection 2026.ABSTRACTRadiopharmaceuticals deliver diagnostic or therapeutic radionuclides to disease sites with molecular precision. Over the past five years, clinical adoption has accelerated, led by U.S. Food and Drug Administration

Y Ye Ri Han

miR-100-5p Enhances Cell Cycle-Mediated Chemoresistance by Modulating the CTDSPL/pRB/E2F1 Signaling Pathway in Oxaliplatin-Resistant Colorectal Cancer Cells

Oncol Res. 2026 Mar 23;34(4):17. doi: 10.32604/or.2026.073080. eCollection 2026.ABSTRACTOBJECTIVE: MicroRNAs (miRNAs) are small, non-coding RNAs that play a key role in the development of chemoresistance in various cancer types, including colorectal cancer (CRC). In this study, we aimed to study the

Y Yen-Pin Chen

Evolution of therapy for autoimmune diseases in pregnancy: a retrospective study from 2000 to 2023

Front Med (Lausanne). 2026 Mar 18;13:1716385. doi: 10.3389/fmed.2026.1716385. eCollection 2026.ABSTRACTINTRODUCTION: Treatment options for rheumatic diseases in pregnancy have consistently changed over the years. The most common therapies for autoimmune diseases during pregnancy include low-dose asp

C Cristina Garufi

Emerging Role of Dual Glucagon-Like Peptide-1 (GLP-1)/Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Agonists in Cardiovascular Prevention

Cureus. 2026 Mar 2;18(3):e104567. doi: 10.7759/cureus.104567. eCollection 2026 Mar.ABSTRACTDual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonists have emerged as a novel therapeutic class with potential relevance for cardiovascular prevention, p

N Nicolle Contreras Figueroa

Artificial Intelligence-Assisted ECG in a Hub-and-Spoke Network in India: Real-World Performance in Acute Coronary Syndrome Detection and Diagnostic Turnaround Times

Cureus. 2026 Mar 1;18(3):e104518. doi: 10.7759/cureus.104518. eCollection 2026 Mar.ABSTRACTINTRODUCTION: Acute coronary syndrome (ACS) remains a leading cause of morbidity and mortality in India, with delayed diagnosis contributing to poor outcomes. The 'Heart Beat' project - an AI-assisted hub-and-

P Praveen Chandra

Impact of anticoagulation on cognitive decline and clinical outcomes in patients with atrial fibrillation and dementia: A retrospective cohort study

J Alzheimers Dis Rep. 2026 Mar 23;10:25424823261433532. doi: 10.1177/25424823261433532. eCollection 2026 Jan-Dec.ABSTRACTBACKGROUND: Atrial fibrillation (AF) and dementia frequently coexist in older adults, yet the impact of anticoagulation on cognitive and clinical outcomes in this population remai

Y Yun Du