The IRE1α Pathway Links Endoplasmic Reticulum Stress to Atherosclerosis-Related Inflammation and Lipid Accumulation

Mediators Inflamm. 2026;2026(1):e4439938. doi: 10.1155/mi/4439938.ABSTRACTEndoplasmic reticulum stress (ER stress) is closely related to the pathogenesis of atherosclerosis through various mechanisms, including inflammatory responses and foam cell formation. However, the mechanisms by which ER stres

M Mariam Bagheri Ekta

Beyond the crystal: molecular dynamics investigations of CETP with varied lipid substrates reveal asymmetric dominant motions

Phys Chem Chem Phys. 2026 Apr 8. doi: 10.1039/d5cp04660b. Online ahead of print.ABSTRACTCholesteryl ester transfer protein (CETP) is a crucial therapeutic target for combating cardiovascular disease (CVD) due to its strong influence in modulating high-density lipoprotein (HDL) levels. CETP is respon

B Bharath Raj Parthasarathy

Mortality trends for diabetes mellitus, hypertension and cardiovascular disease among people living with and without HIV in Brazil during the COVID-19 pandemic, 2020-2022

HIV Med. 2026 Apr 8. doi: 10.1111/hiv.70240. Online ahead of print.ABSTRACTINTRODUCTION: People living with HIV (PLWH) face an increasing burden of non-AIDS-related chronic conditions. However, how the COVID-19 pandemic affected chronic disease-related mortality in this population remains unclear. W

T Tatyellen Natasha da Costa Oliveira

Dental Flossing May Lower the Risk for Incident Ischemic Stroke, Cardioembolic Stroke Subtype, and Atrial Fibrillation

Stroke. 2026 Apr 8. doi: 10.1161/STROKEAHA.125.054440. Online ahead of print.ABSTRACTBACKGROUND: Prior studies have demonstrated an association between oral infection and both incident stroke and atrial fibrillation (AF), a major cause of cardioembolic stroke. However, the impact of preventive oral

S Souvik Sen

EVs-Mediated Intracardiac Crosstalk Mitigates Doxorubicin-Induced Cardiotoxicity

Circ Res. 2026 Apr 8. doi: 10.1161/CIRCRESAHA.125.327827. Online ahead of print.ABSTRACTBACKGROUND: Extracellular vesicles (EVs) are involved in exercise-induced cardiac protection. However, the effects and underlying mechanisms of tissue-specific molecular cargo packaged within these EVs, including

H Hongyun Wang

Clonal Hematopoiesis and Risk of Stroke: Evidence From Over 800 000 Individuals Across 3 Cohorts

Stroke. 2026 Apr 8. doi: 10.1161/STROKEAHA.125.054128. Online ahead of print.ABSTRACTBACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is a common age-related condition that increases risk for cardiovascular disease. However, its relationship with stroke remains uncertain.METHODS: T

K Kun Zhao

T-World Virtual Human Cardiomyocyte. II. Organ-Scale Simulations and Applications

Circ Res. 2026 Apr 8. doi: 10.1161/CIRCRESAHA.125.328123. Online ahead of print.ABSTRACTBACKGROUND: Mechanistic cardiac simulations are increasingly used in research, pharmaceutical development, and regulatory science, yet most existing human cardiomyocyte models lack the generality required for pre

J Jakub Tomek

AI-Derived LA Volume Index, LA/RA and LA/LV Volume Ratios From Coronary Artery Calcium Scans Predict Long-Term Atrial Fibrillation and Stroke

Stroke. 2026 Apr 8. doi: 10.1161/STROKEAHA.125.053401. Online ahead of print.ABSTRACTBACKGROUND: The AI-CVD initiative aims to extract actionable insights from coronary artery calcium (CAC) scans beyond the traditional CAC score. Although AI-derived cardiac chamber volumes predict atrial fibrillatio

A Amir Azimi

Aortic Valve Perforation in Pediatric Granulomatosis With Polyangiitis: A Case Report

Clin Case Rep. 2026 Apr 3;14(4):e72280. doi: 10.1002/ccr3.72280. eCollection 2026 Apr.ABSTRACTGranulomatosis with polyangiitis, formerly Wegener's granulomatosis, is a rare antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis primarily affecting the respiratory tract and kidneys. Cardiov

L Libor Svoboda

Predicting COVID-19 Mortality Risk Among Cardiovascular Disease Patients Using Artificial Intelligence Algorithms: A Retrospective Study on Clinical Data

Health Sci Rep. 2026 Apr 2;9(4):e72070. doi: 10.1002/hsr2.72070. eCollection 2026 Apr.ABSTRACTBACKGROUND AND AIM: With the transition of the COVID-19 outbreak from a pandemic to an endemic state, people are now experiencing COVID-19. COVID-19 is associated with severe symptoms in infected population

R Raoof Nopour

Thrombomodulin as a Potentially Complementing Diagnostic Tool in Non-Pneumonic Bacterial Infections

Infect Drug Resist. 2026 Apr 1;19:587368. doi: 10.2147/IDR.S587368. eCollection 2026.ABSTRACTOBJECTIVE: Soluble thrombomodulin (TM) has been proposed as an endothelial injury marker with potential diagnostic value, particularly for severe pneumococcal community-acquired pneumonia (CAP). Its validati

K Katharina Friedrich

Advances in brain MRI for CAD-associated cognitive impairment with supplementary perspectives from traditional Chinese medicine

Front Med (Lausanne). 2026 Mar 23;13:1770913. doi: 10.3389/fmed.2026.1770913. eCollection 2026.ABSTRACTCoronary artery disease (CAD) and cognitive impairment (CI) are becoming more and more a public health challenge, and the heart-brain axis theory can describe their correlation. In this review, we

Y Yuan-Feng Liu

Aldehyde dehydrogenase 2 rs671 polymorphism may be associated with an increased risk of coronary atherosclerosis among patients with type 2 diabetes mellitus

Front Med (Lausanne). 2026 Mar 23;13:1772461. doi: 10.3389/fmed.2026.1772461. eCollection 2026.ABSTRACTType 2 diabetes mellitus (T2DM) is a risk for coronary atherosclerosis. However, some T2DM patients are prone to coronary atherosclerosis, while another group do not suffer from it. Are there any r

W Weiyong Xu

Associations of High-Sensitivity Cardiac Troponin T, D-Dimer, and N-Terminal Pro-B-Type Natriuretic Peptide with Subclinical Cardiovascular Dysfunction in the General Population: A Retrospective Cross-Sectional Study

Vasc Health Risk Manag. 2026 Apr 2;22:583398. doi: 10.2147/VHRM.S583398. eCollection 2026.ABSTRACTPURPOSE: The purpose of this study was to analyze the relationship between resting high-sensitive serum cardiac troponin T concentration (hs-cTnT), D-dimer, and N-terminal pro-B-type natriuretic peptide

G Grzegorz K Jakubiak

External validation and application of a machine learning-based model for diabetes progression in prediabetes

Front Endocrinol (Lausanne). 2026 Mar 23;17:1746570. doi: 10.3389/fendo.2026.1746570. eCollection 2026.ABSTRACTINTRODUCTION: This study externally validated a machine learning-based model for type 2 diabetes progression (ML-PR) and evaluated its clinical utility in individuals with prediabetes.METHO

S Song Wang

Hypertension management in São Paulo: insights from a computational simulation approach

Lancet Reg Health Am. 2026 Mar 24;57:101449. doi: 10.1016/j.lana.2026.101449. eCollection 2026 May.ABSTRACTBACKGROUND: Hypertension poses significant global health challenges, especially in urban settings where systemic complexity exacerbates its burden. This study aimed to assess whether integrated

P Pei Shan Loo

Mediating Role of Muscle Mass in the Relationship Between Physical Activity and Bone Mass in Female University Students in China

PPAR Res. 2026 Apr 3;2026:5484324. doi: 10.1155/ppar/5484324. eCollection 2026.ABSTRACTOBJECTIVE: We are aimed at investigating the relationships among muscle mass, physical activity, and calcaneal bone mineral density (BMD) in female university students, and exploring the mediating role of muscle m

J Jiaye Wang

Digital Data Collection Reduces Terminal Digit Bias in Haemodynamic and Physical Activity Measures in Pulmonary Arterial Hypertension

Pulm Circ. 2026 Apr 3;16(2):e70290. doi: 10.1002/pul2.70290. eCollection 2026 Jun.ABSTRACTAccurate measurement of cardiopulmonary hemodynamics and exercise capacity is vital for PAH diagnosis and management. Terminal digit bias in clinical measures introduces non-differential error. Remote monitorin

A Alexander M K Rothman

Comparing Effects of Conventionally and Ultrasonically Extracted Flaxseed Mucilages as Sustainable Egg Replacers on the Technological Properties and Nutritional Quality of Dried Wheat Noodles

Food Sci Nutr. 2026 Apr 2;14(4):e71727. doi: 10.1002/fsn3.71727. eCollection 2026 Apr.ABSTRACTEggs are one of the basic ingredients of noodles, providing unique technological and sensory features. Also, eggs are important sources of proteins, vitamins and minerals. Despite excellent technological an

E Elif Yaver

Persistent troponin elevation in the heart of Fabry disease due to coronary microvascular dysfunction

SAGE Open Med Case Rep. 2026 Apr 3;14:2050313X261438242. doi: 10.1177/2050313X261438242. eCollection 2026.ABSTRACTFabry disease is a rare X-linked lysosomal storage disorder caused by GLA variants leading to α-galactosidase A deficiency. The heterozygous phenotype predominantly affects the heart. We

C Clement Tan

Lipodystrophy: an uncommon cause of insulin resistance and young-onset diabetes

JCEM Case Rep. 2026 Apr 6;4(4):luag049. doi: 10.1210/jcemcr/luag049. eCollection 2026 Apr.ABSTRACTInsulin resistance due to lipodystrophy syndromes is an uncommon but important cause of diabetes. It is often overlooked due to limited awareness. Standard glucose-lowering therapies often fail to achie

R Richa Chaturvedi

Diagnostic and prognostic signatures of glomerular membrane dysregulation in immune nephropathies

Front Immunol. 2026 Mar 23;17:1800258. doi: 10.3389/fimmu.2026.1800258. eCollection 2026.ABSTRACTBACKGROUND: Immunonephropathy, encompassing disorders such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), focal segmental glomerulosclerosis (FSGS), minimal change disease (M

C Chengkun Wu

Extracellular vesicles as key biomarkers in COVID-19: insights into disease severity and mortality through CD86 and other immune markers

Front Immunol. 2026 Mar 23;17:1703062. doi: 10.3389/fimmu.2026.1703062. eCollection 2026.ABSTRACTThis study explores the concentration, size, and epitope profiles of extracellular vesicles (EVs) as biomarkers for COVID-19 outcomes. CD86 stood out as a key predictor of mortality, suggesting that EV p

L Lou Soret

Large vessel vasculitis combined with inflammatory bowel disease: epidemiology, shared pathogenesis, and therapeutic advances

Front Immunol. 2026 Mar 23;17:1806045. doi: 10.3389/fimmu.2026.1806045. eCollection 2026.ABSTRACTConcomitant existence of large vessel vasculitis (LVV) and inflammatory bowel disease (IBD) is rare but has gained increasing clinical and research attention. LVV, comprising Takayasu arteritis (TAK) and

M Minghao He