Uncoupling toxicity from efficacy in donor selection for allogeneic hematopoietic cell transplantation: a retrospective cohort study using double machine learning

J Hematol Oncol. 2026 Apr 20;19(1):26. doi: 10.1186/s13045-026-01800-y.ABSTRACTHaploidentical hematopoietic cell transplantation (HCT) offers potent graft-versus-tumor effects but is historically limited by higher non-relapse mortality (NRM) compared to matched unrelated (MUD) or related donors (MRD

R Rohtesh S Mehta

A cluster-randomized trial of labelled cash transfers for uptake of care for chronic conditions among middle-aged and older adults in Burkina Faso

Nat Hum Behav. 2026 Apr 20. doi: 10.1038/s41562-026-02453-0. Online ahead of print.ABSTRACTNon-communicable chronic diseases disproportionately affect people living in low- and middle-income countries, with low linkage to care and healthcare utilization identified as contributors to the considerable

P Pascal Geldsetzer

Cost-effectiveness of genotype-guided acenocoumarol therapy in atrial fibrillation: a pharmacogenomic simulation study in the chilean population

Pharmacogenomics J. 2026 Apr 20;26(3):15. doi: 10.1038/s41397-026-00411-7.ABSTRACTCardiovascular diseases are the leading cause of death in Chile and worldwide, representing a major public health challenge that demands urgent preventive and therapeutic strategies. In atrial fibrillation, anticoagula

M Maximiliano Mena

Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets

Signal Transduct Target Ther. 2026 Apr 21;11(1):142. doi: 10.1038/s41392-026-02630-7.ABSTRACTCardiovascular disease (CVD) predominantly affects elderly individuals and is the leading cause of morbidity, disability, and mortality worldwide. Systemic ageing, especially cardiovascular ageing, contribut

P Pingjing Zheng

Brain, benefit, or burden? Revisiting statins and cognitive function in older adults

Geroscience. 2026 Apr 20. doi: 10.1007/s11357-026-02259-y. Online ahead of print.ABSTRACTStatins are among the most widely prescribed medications for the prevention and treatment of cardiovascular disease, particularly in older adults. However, concerns regarding their potential adverse cognitive ef

Y Yiwen Liu

The Potentials of Stem Cell-Derived Exosomal MicroRNAs in Ferroptosis Modulation: Molecular Insights into Hepatoprotection, Neuroprotection, Cardioprotection, Renoprotection and Pulmonoprotection

No abstractStem Cell Rev Rep. 2026 Apr 21. doi: 10.1007/s12015-026-11126-4. Online ahead of print.NO ABSTRACTPMID:42010206 | DOI:10.1007/s12015-026-11126-4

Q Qamar Abuhassan

Breaking barriers: how cytomegaloviruses manipulate myeloid cells to invade tissues

EMBO Rep. 2026 Apr 20. doi: 10.1038/s44319-026-00763-y. Online ahead of print.ABSTRACTCytomegaloviruses are highly adapted to their hosts through millions of years of co-evolution. Most human (H)CMV infections occur early in life when the virus enters via the mucosal surfaces of the respiratory or g

A Agnibesh Dey

Upstream Drivers of Poor Cardiovascular Health Among Black and White Americans

J Gen Intern Med. 2026 Apr 20. doi: 10.1007/s11606-026-10405-7. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVE: Since cardiovascular health (CVH) precedes cardiovascular disease (CVD) outcomes, our study examines associations between state-level structural racism and CVH among Black and Whit

N Nila Uthirasamy

Prevalence of Atherosclerotic Cardiovascular Disease Risk-Enhancing Factors and Their Association with Primary Prevention Statin Use

J Gen Intern Med. 2026 Apr 20. doi: 10.1007/s11606-026-10423-5. Online ahead of print.ABSTRACTBACKGROUND: Guidelines on primary prevention of atherosclerotic cardiovascular disease (ASCVD) recommend considering risk enhancing factors (REFs) to inform decisions on use of lipid-lowering therapies for

L Linnea M Wilson

Personalized Deep Networks for Enhanced ECG Segmentation

Cardiovasc Eng Technol. 2026 Apr 20. doi: 10.1007/s13239-026-00835-z. Online ahead of print.ABSTRACTElectrocardiography (ECG) plays a vital role in the diagnosis of cardiovascular diseases by analyzing the electrical activity of the heart. ECG semantic segmentation is a subfield focused on sample-wi

M Maylon Pereira Folli

Genetic overlap and shared risk loci between autism spectrum disorder and cardiometabolic traits

Mol Psychiatry. 2026 Apr 20. doi: 10.1038/s41380-026-03563-x. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is a neurodevelopmental condition affecting 2% of the global population. Beyond core symptoms such as social communication deficits and repetitive behaviors, individuals with AS

G Gerard Muntané

Loss of p300/CBP-associated factor aggravates cardiac remodeling via regulation of CAMKK2 acetylation

Exp Mol Med. 2026 Apr 20. doi: 10.1038/s12276-026-01698-z. Online ahead of print.ABSTRACTHere we aim to elucidate the role of the p300/CBP-associated factor (PCAF) in pathological cardiac remodeling. Specifically, we explore how PCAF-mediated acetylation of calcium/calmodulin-dependent protein kinas

Y Yongwoon Lim

VAP1 promotes cardiac fibrosis by enabling PDGFR signaling in myofibroblasts

Exp Mol Med. 2026 Apr 20. doi: 10.1038/s12276-026-01690-7. Online ahead of print.ABSTRACTExcessive fibrogenesis is associated with adverse cardiac remodeling and heart failure. Myofibroblast, primarily derived resident fibroblast, is the effector cell type in cardiac fibrosis. The mechanism whereby

S Shan Huang

Salt and chronic kidney disease

Nat Rev Nephrol. 2026 Apr 20. doi: 10.1038/s41581-026-01076-y. Online ahead of print.ABSTRACTDisruption of sodium homeostasis has a central role in the development and progression of chronic kidney disease (CKD). Excess dietary sodium can overwhelm regulatory mechanisms and amplify pathways that pro

J Jacob Murray

Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids

Nat Commun. 2026 Apr 20;17(1):3570. doi: 10.1038/s41467-026-71391-2.ABSTRACTLeigh syndrome (Leigh) is an untreatable mitochondrial disorder characterized by lactic acidosis and basal ganglia and midbrain pathology, leading to psychomotor regression and early death. We previously uncovered impaired n

C Carmen Menacho

The landscape of human transposable element insertions in Chinese population

No abstractCell Discov. 2026 Apr 21;12(1):29. doi: 10.1038/s41421-026-00886-5.NO ABSTRACTPMID:42009640 | DOI:10.1038/s41421-026-00886-5

J Jiali Wang

Higher plasma serine levels are associated with favorable values of metabolic health markers among middle-aged and older adults in The Maastricht Study

Geroscience. 2026 Apr 20. doi: 10.1007/s11357-026-02237-4. Online ahead of print.ABSTRACTLaboratory studies indicate a mechanistic role for serine in the metabolic benefits induced by dietary restriction of methionine and cysteine. To investigate the association of plasma serine with metabolic healt

T Thomas Olsen

HLA-matched versus haploidentical donor transplantation with post-transplant cyclophosphamide: a study on behalf of the donor/source working group of the Japanese society for transplantation and cellular therapy

No abstractAnn Hematol. 2026 Apr 20;105(5):255. doi: 10.1007/s00277-026-07014-z.NO ABSTRACTPMID:42008176 | DOI:10.1007/s00277-026-07014-z

Y Yosuke Nakaya

Predicting atrial fibrillation after an acute coronary syndrome: insights from the BACS & BAMI study

Clin Res Cardiol. 2026 Apr 20. doi: 10.1007/s00392-026-02898-3. Online ahead of print.ABSTRACTBACKGROUND: Atrial fibrillation (AF) is among the most prevalent arrhythmias. Its onset after an acute coronary syndrome (ACS) is especially notable given the high coronary disease burden. Mineral metabolis

J Jaime Francisco Larre-Guerra

Clopidogrel vs. aspirin in addition to oral anticoagulation as part of double antithrombotic therapy following PCI: a post-hoc analysis of the PERSEO registry

No abstractJ Thromb Thrombolysis. 2026 Apr 20. doi: 10.1007/s11239-026-03286-4. Online ahead of print.NO ABSTRACTPMID:42008084 | DOI:10.1007/s11239-026-03286-4

A Andrea Rubboli

Use of physical activity skills in daily life during a physical activity intervention for women in midlife with elevated risk for cardiovascular disease

No abstractJ Behav Med. 2026 Apr 20. doi: 10.1007/s10865-026-00665-3. Online ahead of print.NO ABSTRACTPMID:42008068 | DOI:10.1007/s10865-026-00665-3

G Gabrielle M Salvatore

Effects of Gilbert syndrome on cardiovascular disease risk reduction: a systematic review

Egypt Heart J. 2026 Apr 20;78(1):25. doi: 10.1186/s43044-026-00738-3.ABSTRACTBACKGROUND: Gilbert syndrome is a human genetic disorder which affects bilirubin metabolism in the liver and results in unconjugated hyperbilirubinemia. While considered a benign condition with only occasional jaundice and

N Nicola Churchill

Arterial stiffness and central blood pressure in non-systemic juvenile idiopathic arthritis: a cross-sectional study

Eur J Pediatr. 2026 Apr 20;185(5):278. doi: 10.1007/s00431-026-06940-4.ABSTRACTJuvenile idiopathic arthritis (JIA), one of the most common chronic inflammatory diseases in childhood, may affect cardiovascular health. We aimed to compare non-invasive markers of arterial stiffness (AS) in children wit

G Gökçen Erfidan

Enhancing Heart Failure Detection in the General Population Using the Steatosis-Associated Fibrosis Estimator

Clin Cardiol. 2026 Apr;49(4):e70318. doi: 10.1002/clc.70318.ABSTRACTPURPOSE: Non-alcoholic fatty liver disease and its fibrotic sequelae have been implicated in the development of cardiovascular complications. This study investigated the association between the steatosis-associated fibrosis estimato

W Wenrui Shi