High-Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Adv Mater. 2026 Jan 28:e14370. doi: 10.1002/adma.202514370. Online ahead of print.ABSTRACTInterest continues to grow in the use of mRNA vaccines and therapeutics. While effective for immunization against infectious diseases, lipid nanoparticle (LNP) formulations used for other mRNA delivery applicat

A Alex G Hamilton

DNTTIP1 drives leukaemogenesis through MiDAC-mediated epigenetic silencing of BMF

Clin Transl Med. 2026 Feb;16(2):e70603. doi: 10.1002/ctm2.70603.ABSTRACTBACKGROUND: Acute leukaemia is a highly aggressive malignancy with significant unmet therapeutic needs, partly due to epigenetic dysregulation. Here, we uncover deoxynucleotidyl transferase terminal-interacting protein 1 (DNTTIP

R Ruolin Xiu

Unbiased Characterization of Atrial Fibrillation Phenotypic Architecture Provides Insight Into Genetic Liability and Clinically Relevant Outcomes

Circ Genom Precis Med. 2026 Jan 28:e004853. doi: 10.1161/CIRCGEN.124.004853. Online ahead of print.ABSTRACTBACKGROUND: Atrial fibrillation (AF) is a common and clinically heterogeneous arrhythmia. Machine learning algorithms can define data-driven disease subtypes in an unbiased fashion, but whether

G Giovanni Davogustto

Genetic Architecture of N-Terminal Pro-B-Type Natriuretic Peptide in a Multiancestry Study Population

Circ Genom Precis Med. 2026 Jan 28:e005130. doi: 10.1161/CIRCGEN.124.005130. Online ahead of print.ABSTRACTBACKGROUND: NPs (natriuretic peptides) are bioactive hormones crucial for regulating blood pressure, glucose homeostasis, and lipid metabolism. Despite the high heritability of circulating NP l

N Naman S Shetty

Race and Ethnic-Specific Burden of Aortic Valve Calcium and Its Association With Long-Term Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis

Circ Cardiovasc Imaging. 2026 Jan 28:e018916. doi: 10.1161/CIRCIMAGING.125.018916. Online ahead of print.ABSTRACTBACKGROUND: Racial and ethnic differences have been reported for aortic valve calcium (AVC) and long-term aortic stenosis (AS). Whether these differences are due to differing risk factor

J Jelani K Grant

Hypertension in Patients With End-Stage Kidney Disease Requiring Dialysis: Bridging the Divide Between Evidence and Practice

Hypertension. 2026 Jan 28. doi: 10.1161/HYPERTENSIONAHA.125.24344. Online ahead of print.ABSTRACTHypertension is a highly prevalent and modifiable risk factor, affecting >80% of patients undergoing dialysis. Its pathophysiology is complex and differs from that of the general population, driven by fa

L Laura Mayeda

Dephospho-Uncarboxylated Matrix Gla-Protein Is Associated With Adverse Outcomes in Heart Failure

Circ Heart Fail. 2026 Jan 28:e012734. doi: 10.1161/CIRCHEARTFAILURE.124.012734. Online ahead of print.ABSTRACTBACKGROUND: MGP (matrix Gla-protein), a known inhibitor of vascular calcification, becomes biologically active by vitamin K-dependent carboxylation. Circulating levels of dpucMGP (dephospho-

M Mahesh K Vidula

Data-driven classification of metabolic-associated steatotic liver disease subtypes predicting hepatic and extrahepatic progression

Chin Med J (Engl). 2026 Jan 28. doi: 10.1097/CM9.0000000000003984. Online ahead of print.ABSTRACTBACKGROUND: Metabolic-associated steatotic liver disease (MASLD) is a heterogeneous condition with highly variable outcomes. We aimed to distinguish the subtypes of MASLD that were associated with varyin

D Da Fang

Population Modeling Approach for Human Cardiac Arrhythmia Risk Prediction

Circ Arrhythm Electrophysiol. 2026 Jan 28:e014249. doi: 10.1161/CIRCEP.125.014249. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular disease is the number 1 killer in industrialized countries, with sudden cardiac death due to ventricular arrhythmias representing a major component. To reduce s

Z Zhen Song

Generation of a PKP2 heterozygous knockout pig model of arrhythmogenic cardiomyopathy

Zool Res. 2026 Jan 18;47(1):139-154. doi: 10.24272/j.issn.2095-8137.2025.044.ABSTRACTArrhythmogenic cardiomyopathy (ACM) confers elevated risk of ventricular arrhythmias and sudden cardiac death, yet limitations in early lesion sampling and model development continue to hinder mechanistic and transl

H Hong-Hui Li

Resting Coronary Blood Flow, Coronary Flow Reserve, and Cardiovascular Outcomes

No abstractCirc Cardiovasc Interv. 2026 Jan 28:e016425. doi: 10.1161/CIRCINTERVENTIONS.126.016425. Online ahead of print.NO ABSTRACTPMID:41603022 | DOI:10.1161/CIRCINTERVENTIONS.126.016425

J John E A Blair

Prevention and Treatment of Maternal Stroke in Pregnancy and Postpartum: A Scientific Statement From the American Heart Association

Stroke. 2026 Jan 28. doi: 10.1161/STR.0000000000000514. Online ahead of print.ABSTRACTStroke remains a rare but life-threatening complication of pregnancy, with significant implications for both maternal and fetal health. Current stroke prevention and treatment guidelines offer limited guidance for

E Eliza C Miller

High-Throughput Methods for Variant Functional Assessment in Cardiac Disease

Circ Genom Precis Med. 2026 Jan 28:e005239. doi: 10.1161/CIRCGEN.125.005239. Online ahead of print.ABSTRACTIn vitro functional modeling of genetic variants has revolutionized our understanding of which variants can cause cardiac disorders, providing insights into their molecular underpinnings. This

R Richard E Dolder

The prognostic significance of uric acid to albumin ratio in patients with aneurysmal subarachnoid hemorrhage following surgical clipping or endovascular interventions: insights from a large cohort study

Front Neurol. 2026 Jan 12;16:1648805. doi: 10.3389/fneur.2025.1648805. eCollection 2025.ABSTRACTBACKGROUND: An increasing number of studies find uric acid to albumin ratio (UAR) plays an important role in predicting prognosis of cardiovascular disease. Nevertheless, the clinical significance of UAR

X Xielin Tang

Artificial intelligence techniques for cardiovascular disease diagnosis via X-ray sensor-based coronary angiography: A bibliometric and systematic review

Digit Health. 2026 Jan 22;12:20552076261417142. doi: 10.1177/20552076261417142. eCollection 2026 Jan-Dec.ABSTRACTPURPOSE: To systematically evaluate the application of artificial intelligence (AI) techniques in X-ray sensor-based coronary angiography for cardiovascular disease (CVD) diagnosis, mappi

H Hao Ren

Benchmarking survival machine learning models for 10-year cardiovascular disease risk prediction using large-scale electronic health records

Digit Health. 2026 Jan 22;12:20552076251408534. doi: 10.1177/20552076251408534. eCollection 2026 Jan-Dec.ABSTRACTOBJECTIVE: To evaluate the performance of machine learning (ML)-based survival models for 10-year cardiovascular disease (CVD) risk prediction using large-scale electronic health records

T Tianyi Liu

AI enhancing differential diagnosis of acute chronic obstructive pulmonary disease and acute heart failure

iScience. 2025 Dec 4;29(1):114197. doi: 10.1016/j.isci.2025.114197. eCollection 2026 Jan 16.ABSTRACTDifferentiating acute exacerbation of chronic obstructive pulmonary disease (AECOPD) from acute heart failure (AHF) is clinically challenging due to overlapping symptoms, especially in resource-limite

Y Yu Lao

Physiological responses of children with surgically corrected congenital heart disease during high-altitude trekking: an exploratory observational study

Front Pediatr. 2026 Jan 12;13:1718577. doi: 10.3389/fped.2025.1718577. eCollection 2025.ABSTRACTBACKGROUND: Children with surgically corrected congenital heart disease (CHD) are often perceived as fragile and discouraged from engaging in physical activity, despite evidence that structured exercise i

K Kwang Ho Choi

Integration of pre-existing cardiovascular comorbidity into CDK4/6 inhibitor selection for breast cancer

Ther Adv Drug Saf. 2026 Jan 23;17:20420986251414588. doi: 10.1177/20420986251414588. eCollection 2026.ABSTRACTBACKGROUND: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors differ in cardiovascular (CV) safety. Ribociclib has been associated with a higher risk of CV adverse events compared to palbocicl

C Chanhyun Park

Case Report: Emergency mitral valve plasty in an unstable dog with left atrial rupture secondary to myxomatous mitral valve disease

Front Vet Sci. 2026 Jan 12;12:1653646. doi: 10.3389/fvets.2025.1653646. eCollection 2025.ABSTRACTOBJECTIVE: To describe the medical and surgical management of recurrent left atrial rupture (LAR) in a dog with severe mitral regurgitation (MR). This report focuses on challenges encountered with perica

T Tomoki Wada

Immunoengineering strategies using nanoparticles for obesity treatment

Nano Res. 2025 Dec;18(12):94907707. doi: 10.26599/NR.2025.94907707.ABSTRACTObesity has emerged as a global epidemic, posing severe challenges to public health and contributing to various complications, including metabolic disorders, cardiovascular disease, and type 2 diabetes. This review provides a

N Neda Mohaghegh

Work conditions are associated with physical health in later life: a longitudinal cohort study in Taiwan

Innov Aging. 2025 Dec 13;10(1):igaf142. doi: 10.1093/geroni/igaf142. eCollection 2026.ABSTRACTBACKGROUND AND OBJECTIVES: Work occupies a significant portion of adult life, and work conditions are associated with health among workers. This study examined the association between work conditions and mo

W Wan-Ju Cheng

Bioengineered heart valves for personalized therapy: advances in manufacturing and clinical challenges

Front Bioeng Biotechnol. 2026 Jan 12;13:1714534. doi: 10.3389/fbioe.2025.1714534. eCollection 2025.ABSTRACTValvular heart diseases (VHDs) remain a significant clinical challenge, with mechanical and bioprosthetic valves offering only temporary solutions and failing to address long-term complications

M Mahnoor Saeed

Hepatic-vascular crosstalk via GRK2: fenofibrate improves endothelial function by restoring lipid metabolism and NO signaling in obese mice

Front Physiol. 2026 Jan 12;16:1734746. doi: 10.3389/fphys.2025.1734746. eCollection 2025.ABSTRACTBACKGROUND: Obesity is often linked to endothelial dysfunction, a key factor in the development of cardiovascular and metabolic diseases. Reduced nitric oxide (NO) bioavailability is a defining feature o

K Kumiko Taguchi