Impact of Baseline Polyneuropathy Severity on Eplontersen Efficacy in the NEURO-TTRansform Clinical Trial

J Peripher Nerv Syst. 2026 Sep;31(3):e70167. doi: 10.1111/jns.70167.ABSTRACTBACKGROUND AND AIMS: In the NEURO-TTRansform clinical trial (NCT04136184), eplontersen improved neuropathy impairment and quality of life (QoL) through Week 66 versus the NEURO-TTR historical placebo in patients with heredit

T Thomas H Brannagan

SDH inhibition quenches rheumatoid arthritis flare-associated IL-1β+IFN-γ+ macrophages via NF-κB/STAT4

CONCLUSIONS: SDH functions as a metabolic-immune checkpoint in pathogenic IL-1β^(+)NFKB1^(+)IFN-γ^(+)STAT4^(lo) MΦs in RA. Targeting SDH may concurrently resolve mitochondrial dysfunction and inflammation in patients experiencing disease flares, with synovial enrichment of TLR5, SDH, IL-1β, NFKB1, a

S Stephanie R Zack

Potential Pathomechanisms of Reverse Transfusion-Related Acute Lung Injury (TRALI): An Under-Recognized Transfusion Complication

Transfus Med Rev. 2026 Aug 7:151023. doi: 10.1016/j.tmrv.2026.151023. Online ahead of print.ABSTRACTTransfusion-related acute lung injury (TRALI) is a potentially fatal blood transfusion complication that is characterized by noncardiogenic pulmonary edema within 6 hours post-transfusion. Specific th

J Jonas Lowack

Sex differences in triage priority, predictors, and outcomes in consecutive emergency department patients with chest pain

Eur J Intern Med. 2026 Sep 4:107165. doi: 10.1016/j.ejim.2026.107165. Online ahead of print.ABSTRACTBACKGROUND: Chest pain (CP) is a common reason for Emergency Department (ED) presentation and may signal life-threatening cardiovascular emergencies (CVE). Sex-related differences in CP management are

E E Fanelli

Use of fixed-ratio combination of basal insulin and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in Asians with type 2 diabetes

Prim Care Diabetes. 2026 Sep 4:S1751-9918(26)00153-1. doi: 10.1016/j.pcd.2026.08.005. Online ahead of print.ABSTRACTPeople with type 2 diabetes in Asia have heterogeneous phenotypes but share common features of young age-at-diagnosis, low body mass index, low pancreatic beta-cell capacity, rapid dec

A Alice Pik-Shan Kong

Large-scale multiethnic electronic health record resource for diabetes complications research: the North West London Diabetes Cohort (NWLDC) - cohort profile

BMJ Open. 2026 Sep 4;16(9):e114566. doi: 10.1136/bmjopen-2025-114566.ABSTRACTPURPOSE: The North West London Diabetes Cohort is established to provide systematic characterisation of a large diabetes population as a foundation for complications research and prognostic modelling. Many predictive modell

Z Zeinab Schaefer

Mental disorders, receipt of cardiac care following myocardial infarction and the impact of the COVID-19 pandemic: a cohort study

BMJ Open. 2026 Sep 4;16(9):e124463. doi: 10.1136/bmjopen-2026-124463.ABSTRACTOBJECTIVES: To compare receipt of guideline-informed myocardial infarction (MI) care by mental disorder and assess how the COVID-19 pandemic affected associations.DESIGN: A population-based cohort study using linked electro

K Kelly Fleetwood

Rapidly progressive glomerulonephritis in rheumatoid arthritis: an early presentation of ANCA-associated vasculitis

BMJ Case Rep. 2026 Sep 2;19(9):e272069. doi: 10.1136/bcr-2026-272069.ABSTRACTAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a multisystem autoimmune disease that may present diagnostic challenges, particularly in patients with coexisting autoimmune conditions. Although the coex

J Jegadis Sreeneyasan

Rapid progression of a small penetrating aortic ulcer to rupture in the setting of Staphylococcus aureus bacteraemia

BMJ Case Rep. 2026 Sep 2;19(9):e274076. doi: 10.1136/bcr-2026-274076.ABSTRACTAn octogenarian woman with heart failure, atrial fibrillation and asthma was admitted with a cervical phlegmon and methicillin-sensitive Staphylococcus aureus bacteraemia. Initial CT angiography (CTA) showed a small infrare

A Agnieszka Mijalska

Subacute aortic dissection presenting as heart failure due to aortic valve insufficiency and right coronary artery dissection

BMJ Case Rep. 2026 Sep 2;19(9):e272319. doi: 10.1136/bcr-2026-272319.ABSTRACTSubacute thoracic aortic aneurysm dissection (TAAD) often presents with a clinical profile distinct from its acute form, which can closely mimic common cardiac conditions, risking diagnostic delay. We report a case of subac

H Hediyeh Vaseli

Recurrent incomplete Kawasaki disease with small-joint-predominant arthritis during the acute phase

BMJ Case Rep. 2026 Sep 2;19(9):e272465. doi: 10.1136/bcr-2026-272465.ABSTRACTAn adolescent boy was admitted on illness day 6 with fever and left cervical lymphadenopathy. He had been treated for complete Kawasaki disease (KD) approximately a decade earlier. He subsequently developed painful swelling

K Kentaro Suzuki

Delisting From the Kidney Transplant Waiting List: Impact on Patient Survival

Clin Transplant. 2026 Sep;40(9):e70673. doi: 10.1111/ctr.70673.ABSTRACTBACKGROUND: Kidney transplant programs may remove high-risk patients from the national transplant waiting list to mitigate peri-transplant complications and enhance overall post-transplant survival. The phrase "too sick," frequen

P Parker Schimmers

Early-Diastolic Right Ventricle-Pulmonary Artery Pressure Gradient by Doppler Echocardiography to Guide Cardiac Magnetic Resonance Assessment of Pulmonary Regurgitation after Right Ventricular Outflow Tract Reconstruction

Echocardiography. 2026 Sep;43(9):e70614. doi: 10.1111/echo.70614.ABSTRACTBACKGROUND: Pulmonary regurgitation (PR) after right ventricular outflow tract (RVOT) reconstruction is a major driver of right ventricular (RV) remodeling. Cardiac magnetic resonance (CMR) is the reference standard for quantif

J Junpei Kawamura

Left Atrial Reservoir Strain and Heart Failure Rehospitalization Burden in Acute Heart Failure With Atrial Fibrillation

Echocardiography. 2026 Sep;43(9):e70616. doi: 10.1111/echo.70616.ABSTRACTPURPOSE: To examine associations of left atrial reservoir strain, diameter, and volume index with first rehospitalization and recurrent readmission burden in acute heart failure with atrial fibrillation.METHODS: Among 716 enrol

J Jumpei Yamamoto

Lower serum serotonin is associated with greater cardiovascular risk burden and poorer cognitive outcomes in mild cognitive impairment and amyloid-positive participants

Neuroscience. 2026 Sep 4:S0306-4522(26)00613-5. doi: 10.1016/j.neuroscience.2026.09.005. Online ahead of print.ABSTRACTBoth serum serotonin and cardiovascular-risk (CVR) burden are implicated in Alzheimer's disease (AD)-related vascular and neurodegenerative processes, yet their interrelationship ac

N Nahlah Fahad Alreshidi

Historical Gaps in Kidney and Cardiovascular Risk Assessment Among Patients with Diabetes and Hypertension: A Real-World Primary Care Study

Can J Diabetes. 2026 Sep 4:S1499-2671(26)00347-3. doi: 10.1016/j.jcjd.2026.08.185. Online ahead of print.ABSTRACTINTRODUCTION: Individuals with both diabetes and hypertension are at high risk for micro- and macrovascular complications, underscoring the importance of regular monitoring of HbA1C, chol

J Jian Roushani

Diagnosis-time Risk Stratification for Tuberculosis Mortality in a Nationwide Public-Private Mix Program

Int J Infect Dis. 2026 Sep 4:109102. doi: 10.1016/j.ijid.2026.109102. Online ahead of print.ABSTRACTOBJECTIVES: Mortality remains a major barrier to tuberculosis (TB) control, as many deaths occur shortly after diagnosis. We aimed to identify determinants of mortality and develop diagnosis-time risk

Y Yun-Jeong Jeong

Endocannabinoid system dysregulation in non-communicable diseases: Implications for skeletal muscle health

Exp Gerontol. 2026 Sep 4:113312. doi: 10.1016/j.exger.2026.113312. Online ahead of print.ABSTRACTNon-communicable diseases (NCDs) and their associated skeletal muscle (SkM) degeneration substantially contribute to morbidity and mortality. Interestingly, the endocannabinoid system (ECS) is increasing

K Kaat Vanderbeke

Pelvic venous disorders (PeVD): objective hemodynamic signature from quantitative 2-dimensional phase-contrast magnetic resonance imaging

J Vasc Surg Venous Lymphat Disord. 2026 Sep 4:102616. doi: 10.1016/j.jvsv.2026.102616. Online ahead of print.ABSTRACTOBJECTIVE: The lack of objective hemodynamic criteria for diagnosing pelvic venous disorders (PeVD) limits interdisciplinary consensus in vascular surgery, radiology, phlebology and g

S Shih-Chung Wang

MicroRNA modulation and crosstalk of SREBP and NF-κB pathways in herbal nanoparticle therapies for hypercholesterolemia

Fitoterapia. 2026 Sep 4:107451. doi: 10.1016/j.fitote.2026.107451. Online ahead of print.ABSTRACTHypercholesterolemia is increasingly recognized as a multifactorial metabolic disorder characterized by dysregulated cholesterol homeostasis and chronic inflammation, both of which accelerate atheroscler

P Putri Cahaya Situmorang

Anaemia prevalence, characterisation, and clinical impact in intermittent claudication

Ann Vasc Surg. 2026 Sep 4:S0890-5096(26)00630-8. doi: 10.1016/j.avsg.2026.08.033. Online ahead of print.ABSTRACTINTRODUCTION: The prevalence and clinical impact of anaemia in patients with intermittent claudication is unclear and consequently evidence-based treatment strategies are ambiguous. This s

J Jae Seon Hong

A Meta-analysis of Female Enrollment in Peripheral Artery Disease Randomized Controlled Trials in North America: 2001-2021

Ann Vasc Surg. 2026 Sep 4:S0890-5096(26)00648-5. doi: 10.1016/j.avsg.2026.08.051. Online ahead of print.ABSTRACTOBJECTIVES: Despite the recent improvement in female recruitment to randomized controlled medical research trials (RCTs), males continue to predominate in cardiovascular trials due to mult

L Levester Kirksey

Physical Exercise as an Adjunctive Therapy in Obesity-Associated Cancer: From Biological Rationale to a Pragmatic Clinical Framework

Semin Cancer Biol. 2026 Sep 4:102618. doi: 10.1016/j.semcancer.2026.102618. Online ahead of print.ABSTRACTObesity represents a well-established risk factor for numerous cancers, contributing substantially to the global burden of this disease. In parallel, accumulating evidence supports the relevant

G Giuseppe Annunziata

Emerging role of GLP-1 mono, dual, and triple agonists in the management of MASH-related fibrosis

Cell Rep Med. 2026 Sep 4:103023. doi: 10.1016/j.xcrm.2026.103023. Online ahead of print.ABSTRACTRecent therapeutic advances have resulted in US Food and Drug Administration (FDA) approval of the first pharmacological agents-resmetirom and semaglutide-for advanced metabolic dysfunction-associated ste

F Federica Tavaglione