Cell Commun Signal. 2026 Jul 15. doi: 10.1186/s12964-026-03066-w. Online ahead of print.ABSTRACTBACKGROUND: Chronic tissue inflammation causes progressive tissue damage, organ dysfunction, and increased susceptibility to inflammatory diseases. Viral infections are major drivers of this process, but
J Transl Med. 2026 Jul 15. doi: 10.1186/s12967-026-08588-y. Online ahead of print.ABSTRACTBACKGROUND: Male fertility has declined globally. Diabetes and aging are major contributors to the reduced sperm production and testicular dysfunction. Elevated glucagon signaling leads to diabetic complication
J Transl Med. 2026 Jul 15. doi: 10.1186/s12967-026-08576-2. Online ahead of print.ABSTRACTOBJECTIVES: To examine whether patients with autoimmune diseases receive differential cardiometabolic and inflammatory laboratory monitoring compared to matched controls in primary care, and to identify predict
BMC Public Health. 2026 Jul 15. doi: 10.1186/s12889-026-28499-3. Online ahead of print.ABSTRACTBACKGROUND: Population aging is accelerating worldwide and poses long-term health challenges for four major chronic noncommunicable diseases (NCDs), including cancer, cardiovascular disease (CVD), chronic
BMC Public Health. 2026 Jul 15. doi: 10.1186/s12889-026-28564-x. Online ahead of print.ABSTRACTBACKGROUND: Randomized trials have not clearly characterized the long-term cardiovascular benefit and preventable disease burden that may correspond to sustained improvement in depressive symptoms in middl
BMC Neurol. 2026 Jul 15. doi: 10.1186/s12883-026-05173-0. Online ahead of print.ABSTRACTBACKGROUND: As stroke remains a major public health challenge in China, numerous studies have characterized the epidemiological features and distribution of stroke prevalence across provinces. However, convention
BMC Gastroenterol. 2026 Jul 15. doi: 10.1186/s12876-026-05127-3. Online ahead of print.ABSTRACTBACKGROUND: Triglyceride-glucose index to high density lipoprotein cholesterol ratio (TyG/HDL-C ratio) is a novel surrogate indicator for insulin resistance. However, the predictive value of TyG/HDL-C rati
High Blood Press Cardiovasc Prev. 2026 Jul 15. doi: 10.1007/s40292-026-00814-4. Online ahead of print.ABSTRACTINTRODUCTION: Orforglipron, an oral non-peptide GLP-1 receptor agonist, improves multiple cardiometabolic risk factors. However, prior modeling used only the 2013 Pooled Cohort Equations (PC
High Blood Press Cardiovasc Prev. 2026 Jul 15. doi: 10.1007/s40292-026-00815-3. Online ahead of print.ABSTRACTThe 2025 European Society of Cardiology (ESC) Guidelines on cardiovascular disease in pregnancy introduce a life-course approach to cardiovascular prevention, extending risk assessment and m
Drug Saf. 2026 Jul 15. doi: 10.1007/s40264-026-01678-2. Online ahead of print.ABSTRACTTargeted therapies have transformed the treatment landscape for patients with chronic lymphocytic leukemia (CLL). These therapies include the selective B-cell lymphoma-2 (BCL-2) inhibitor venetoclax and Bruton's ty
Neurol Sci. 2026 Jul 16;47(8):637. doi: 10.1007/s10072-026-09221-y.ABSTRACTBACKGROUND: Circadian rhythm dysregulation may contribute to sleep-wake disorders and cognitive impairment. In the elderly, circadian abnormalities have been observed in Mild Cognitive Impairment (MCI), suggesting a possible
Heart Fail Rev. 2026 Jul 16;31(1):86. doi: 10.1007/s10741-026-10657-9.ABSTRACTCardiovascular disease represents the leading cause of death in patients with Anderson-Fabry disease (FD), with sudden cardiac death (SCD) being one of the most frequently reported causes of mortality. However, a significa
Electronic health records (EHRs) provide rich longitudinal disease histories, but existing methods for analysing these data typically treat diseases in isolation¹ and rarely integrate germline genetics. Here we present ALADYNOULLI, a Bayesian generative framework that jointly models longitudinal EHR
Identifying transcriptional enhancers and their target genes is essential for understanding gene regulation and the effect of human genetic variation on disease^(1-6). Here we create and evaluate a resource of more than 92 million enhancer-gene regulatory interactions across 1,458 biosamples coverin
Mol Psychiatry. 2026 Jul 15. doi: 10.1038/s41380-026-03755-5. Online ahead of print.ABSTRACTSleep integrity has been recognized as a crucial contributor to maintain health and cellular homeostasis. Current evidence supports a bidirectional relationship between sleep disorders and different molecular
Sci Rep. 2026 Jul 16;16(1):22287. doi: 10.1038/s41598-026-62460-z.ABSTRACTRetinol-binding protein 4 (RBP4) is a key transporter of all-trans-retinol (vitamin A), circulating in blood as either holo-RBP4 (retinol-bound) or apo-RBP4 (retinol-free). Dysregulated RBP4 levels, particularly an imbalance b
Sci Rep. 2026 Jul 15. doi: 10.1038/s41598-026-61149-7. Online ahead of print.ABSTRACTThis study aimed to investigate the associations between dietary fat quantity and quality and the incidence of metabolic syndrome (MetS) over a 2-year follow-up period. Additionally, we explored the cross-sectional
Sci Rep. 2026 Jul 16. doi: 10.1038/s41598-026-60873-4. Online ahead of print.ABSTRACTMonitoring home non-invasive ventilation (NIV) typically relies on commercial ventilator software that processes raw signals to estimate key respiratory parameters. However, the algorithms used by different manufact
Sci Rep. 2026 Jul 15;16(1):22272. doi: 10.1038/s41598-026-61415-8.ABSTRACTAbout 3-10% of patients with acute ischemic stroke (AIS) have active cancer. Malignancy-associated hypercoagulability (MAH) is an established cause of cancer-associated stroke. Nonbacterial thrombotic endocarditis (NBTE) is a
Bone Res. 2026 Jul 15;14(1):73. doi: 10.1038/s41413-026-00556-y.ABSTRACTChronic kidney disease (CKD) leads to bone loss and bone marrow adipose tissue (BMAT) accumulation. Sclerostin and dickkopf-1 (DKK1) are two inhibitors of Wnt signalling, which suppress bone formation, promote bone marrow adipog
Clin Obes. 2026 Aug;16(4):e70097. doi: 10.1111/cob.70097.ABSTRACTObesity is a key risk factor for chronic disease and multimorbidity, yet variation in how obesity is defined may influence risk estimation in clinical practise. Waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) are better at ca
Heart. 2026 Jul 15:heartjnl-2025-326875. doi: 10.1136/heartjnl-2025-326875. Online ahead of print.ABSTRACTCancer therapy has dramatically changed over the past many decades, not only in efficacy but also complexity, with targeted therapeutics that have novel mechanisms of action. As a direct result
Int Heart J. 2026 Jul 14. doi: 10.1536/ihj.26-205. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is a major long-term complication following heart transplantation (HT). The safety and efficacy of sodium-glucose cotransporter 2 inhibitors (SGLT2i) for HT recipients with CKD remains uncle
J Atheroscler Thromb. 2026 Jul 15. doi: 10.5551/jat.66064. Online ahead of print.ABSTRACTAIMS: Non-fasting triglyceride measurements have become increasingly common in screening for atherosclerotic cardiovascular disease. However, evidence of its predictive value for diabetes mellitus is limited to
