Alzheimers Dement. 2026 Jul;22(7):e71661. doi: 10.1002/alz.71661.ABSTRACTINTRODUCTION: Alzheimer's disease (AD) dementia in Down syndrome (DS) occurs at predictable ages. It is unclear whether age can differentiate across AD stages (amyloid positivity, tau positivity, mild cognitive impairment [MCI]
Alzheimers Dement. 2026 Jul;22(7):e71631. doi: 10.1002/alz.71631.ABSTRACTBACKGROUND: The study aim is to investigate whether blood biomarkers (BBMs) of Alzheimer's disease (AD) pathology are associated with postoperative cognitive dysfunction (POCD) after cardiac surgery.METHODS: Cognitive performan
Clin Drug Investig. 2026 Jul 14. doi: 10.1007/s40261-026-01583-7. Online ahead of print.ABSTRACTBACKGROUND: Janus kinase (JAK) inhibitors are a new class of medications that are changing how we treat inflammatory skin diseases. Even though these drugs are increasingly being approved for various skin
Hypertens Res. 2026 Jul 14. doi: 10.1038/s41440-026-02730-5. Online ahead of print.ABSTRACTAortic dissection (AD), aortic aneurysm (AA), and peripheral artery disease (PAD) are associated with higher mortality. However, validated prediction models for these conditions remain scarce. We developed ris
Eur J Pediatr. 2026 Jul 15;185(8):576. doi: 10.1007/s00431-026-07206-9.ABSTRACTPertussis resurged globally, after the relaxation of COVID-19 measures, underscoring its continued relevance as a public health concern, yet data remain limited on the factors associated with severe disease in children. T
Sci Rep. 2026 Jul 14. doi: 10.1038/s41598-026-62249-0. Online ahead of print.ABSTRACTFabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in the GLA gene, leading to deficient α-galactosidase A activity and systemic glycosphingolipid accumulation. Diagnosis remains challe
NPJ Digit Med. 2026 Jul 14. doi: 10.1038/s41746-026-02977-9. Online ahead of print.ABSTRACTDual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) is traditionally guided by rule-based scores providing static, single-time-point or fixed time-interval estimates with modest
NPJ Microgravity. 2026 Jul 14. doi: 10.1038/s41526-026-00635-8. Online ahead of print.ABSTRACTHumans will return to the Moon and travel to deep space on their journey to Mars. Space exploration presents significant hazards to human health, including exposure to ionizing radiation (IR) from galactic
Microsyst Nanoeng. 2026 Jul 14;12(1):263. doi: 10.1038/s41378-026-01385-z.ABSTRACTCigarette smoking and hyperlipidemia are major risk factors for cardiovascular disease. However, the mechanisms underlying their synergistic cardiotoxic effects remain insufficiently elucidated, particularly at the cel
Ann Rheum Dis. 2026 Jul 14:S0003-4967(26)00367-5. doi: 10.1016/j.ard.2026.06.020. Online ahead of print.ABSTRACTOBJECTIVES: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is commonly treated with glucocorticoids and B-cell depletion, but cumulative toxicity and relapse underscore the need for alte
Am J Med. 2026 Jul 14:S0002-9343(26)00516-4. doi: 10.1016/j.amjmed.2026.07.001. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: Controlling blood pressure (BP) reduces cardiovascular morbidity and mortality but is often not achieved in clinical practice. Tailoring therapy to an individual's he
Mech Ageing Dev. 2026 Jul 14:112229. doi: 10.1016/j.mad.2026.112229. Online ahead of print.ABSTRACTThe identification of reliable biomarkers of ageing represents a major challenge in biomedical research, particularly in the context of increasing life expectancy and the growing burden of chronic dise
Ann Vasc Surg. 2026 Jul 14:S0890-5096(26)00499-1. doi: 10.1016/j.avsg.2026.06.047. Online ahead of print.ABSTRACTOBJECTIVES: Peripheral artery disease (PAD) is a common atherosclerotic disorder characterized by progressive arterial narrowing in the limbs. This study aims to determine the efficacy an
Bone. 2026 Jul 14:118014. doi: 10.1016/j.bone.2026.118014. Online ahead of print.ABSTRACTBACKGROUND: Fractures in older adults arise from complex interactions between bone fragility, falls, and comorbid conditions. This study aimed to map the comorbidity environment of osteoporosis (M80/M81) by sex
Int J Cardiol. 2026 Jul 14:134670. doi: 10.1016/j.ijcard.2026.134670. Online ahead of print.ABSTRACTBACKGROUND: Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy associated with adverse outcomes. Quantification of myocardial amyloid burden is essential for risk stratification. Although card
Arq Neuropsiquiatr. 2026 Jun;84(6):1-10. doi: 10.1055/s-0046-1825525. Epub 2026 Jul 14.ABSTRACTBACKGROUND: Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by both motor and non-motor symptoms, with autonomic dysfunction significantly impacting patients' quality of life
Phys Med Biol. 2026 Jul 14. doi: 10.1088/1361-6560/ae8aac. Online ahead of print.ABSTRACTOBJECTIVE: Coronary microvascular dysfunction plays a central role in major cardiovascular diseases, yet non-invasive imaging of the human coronary microcirculation remains an unresolved challenge in clinical pr
Thorac Cardiovasc Surg. 2026 Jul 14. doi: 10.1055/a-2798-0277. Online ahead of print.ABSTRACTBACKGROUND: Postoperative cognitive dysfunction (POCD) is a common complication following aortic arch replacement. This study aimed to identify risk factors for early POCD in patients undergoing aortic arch
Eur Heart J. 2026 Jul 14:ehag447. doi: 10.1093/eurheartj/ehag447. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Micro- and nanoplastics (MNPs) are emerging risk factors for cardiovascular diseases. The present study aimed to evaluate the burden of MNPs in coronary blood across the spectrum of c
Arch Gerontol Geriatr. 2026 Jul 8;150:106356. doi: 10.1016/j.archger.2026.106356. Online ahead of print.ABSTRACTBACKGROUND: Evidence regarding the combined association of the visceral adiposity index (VAI), an indicator of visceral fat distribution and dysfunction, and handgrip strength with cardiov
Pediatr Res. 2026 Jul 14. doi: 10.1038/s41390-026-05152-8. Online ahead of print.ABSTRACTBACKGROUND: Genetic mutations causing dysregulation of the RAS/mitogen-activated protein kinase pathway contribute to hypertrophic cardiomyopathy (HCM). Genotype-phenotype associations in this population remain
Hypertens Res. 2026 Jul 14. doi: 10.1038/s41440-026-02724-3. Online ahead of print.ABSTRACTEssential hypertension (EH) remains the leading modifiable risk factor for cardiovascular morbidity and mortality, yet even optimally treated patients carry residual cardiovascular risk. Emerging evidence sugg
Nat Cell Biol. 2026 Jul 14. doi: 10.1038/s41556-026-02022-7. Online ahead of print.ABSTRACTCoronary atherosclerosis underlies life-threatening conditions such as myocardial infarction and stroke, yet its cellular dynamics remain incompletely understood. Here, through single-cell RNA sequencing of 27
Sci Rep. 2026 Jul 14. doi: 10.1038/s41598-026-61043-2. Online ahead of print.ABSTRACTHigh-density lipoprotein cholesterol (HDL-C) is inversely associated with cardiovascular diseases and may protect kidney function. This study evaluated the impact of early post-transplant HDL-C changes on clinical o
