Clin Transl Sci. 2026 May;19(5):e70584. doi: 10.1111/cts.70584.ABSTRACTClopidogrel is an antiplatelet agent widely utilized in cardiology. It is a prodrug activated in the liver by the cytochrome P450 isoform CYP2C19. Variability in the CYPC2C19 gene influences the activation and efficacy of clopido
Diabetes Obes Metab. 2026 May 11. doi: 10.1111/dom.70868. Online ahead of print.ABSTRACTAIMS: To evaluate the impact of long-term glycemic exposure and control status on cognitive function in older adults.MATERIALS AND METHODS: Using repeated measurements of fasting blood glucose (FBG) from the Pred
Diabetes Obes Metab. 2026 May 11. doi: 10.1111/dom.70851. Online ahead of print.ABSTRACTOBJECTIVE: Metabolic dysfunction-associated fatty liver disease (MASLD) is reversible in the preclinical metabolic stage. However, the temporal interactions between hepatic steatosis and cardiometabolic abnormali
Hypertens Res. 2026 May 11. doi: 10.1038/s41440-026-02674-w. Online ahead of print.ABSTRACTPatients in the post-advanced acute kidney injury (post-advanced AKI) period are vulnerable to cardiovascular complications, infection, and mortality. Whether seasonal influenza vaccination mitigates these ris
Nat Commun. 2026 May 11. doi: 10.1038/s41467-026-72949-w. Online ahead of print.ABSTRACTBranched-chain amino acids play critical roles in cardiac physiology and diseases. Genetic deficiency in the valine catabolic enzyme ACAD8 is clinically associated with isobutyryl-CoA deregulation and cardiomyopa
Signal Transduct Target Ther. 2026 May 12;11(1):175. doi: 10.1038/s41392-026-02709-1.ABSTRACTDespite therapeutic advances, multiple myeloma (MM) remains incurable, largely due to relapse and the emergence of drug resistance driven by clonal evolution and alterations in the bone marrow (BM) microenvi
Diabetes Obes Metab. 2026 May 11. doi: 10.1111/dom.70858. Online ahead of print.ABSTRACTAIMS: Prediabetes and left ventricular hypertrophy (LVH) are common risk factors in adults with hypertension. Whether their coexistence, particularly in the presence of subclinical myocardial injury or stress (ma
Mamm Genome. 2026 May 11;37(1):67. doi: 10.1007/s00335-026-10222-7.ABSTRACTGlutathione is a ubiquitous antioxidant with critical roles in xenobiotic clearance and aerobic metabolism. Reduced glutathione (GSH) is converted to its oxidized counterpart, GSSG, in the process of neutralizing free radical
Curr Nutr Rep. 2026 May 12;15(1):45. doi: 10.1007/s13668-026-00764-2.ABSTRACTBACKGROUND: Digital technologies are increasingly used to promote healthier behaviors and prevent noncommunicable diseases (NCDs). Diet and physical activity are key determinants of cardiometabolic health, where digital too
Metabolomics. 2026 May 11;22(3):69. doi: 10.1007/s11306-026-02449-x.ABSTRACTBACKGROUND: Heart failure with preserved ejection fraction (HFpEF) accounts for nearly half of heart failure cases, with obesity emerging as a key pathophysiologic driver. Oxylipins are lipid signaling molecules linked to ad
Semin Immunopathol. 2026 May 11;48(1):6. doi: 10.1007/s00281-026-01075-y.ABSTRACTClimate extremes are increasingly shaping both environmental and human health outcomes. Global warming has led to a rise in the frequency, duration, and intensity of extreme temperature events, with heatwaves emerging a
Eur J Clin Pharmacol. 2026 May 12;82(6):150. doi: 10.1007/s00228-026-04071-1.ABSTRACTBACKGROUND: Loop diuretics relieve congestion in chronic heart failure (CHF). We systematically reviewed randomised clinical trials (RCTs) evaluating their effects.METHODS: A systematic search was conducted across m
NPJ Digit Med. 2026 May 11. doi: 10.1038/s41746-026-02747-7. Online ahead of print.ABSTRACTObesity is a risk factor for cardiovascular diseases (CVD). We evaluated a 52-week digital Health Behaviour Change Support System (HBCSS) with a one-year follow-up to treat overweight and Class I obesity. A to
Heart Vessels. 2026 May 11. doi: 10.1007/s00380-026-02673-4. Online ahead of print.ABSTRACTWith the increasing use of minimally invasive catheter-based therapies, early identification of severe aortic stenosis (AS) has become essential. The slow upstroke waveform (Tardus) observed in carotid artery
Sci Rep. 2026 May 11. doi: 10.1038/s41598-026-51459-1. Online ahead of print.ABSTRACTGrowing evidence from preclinical studies suggests that meal timing influences metabolic health. However, evidence in humans is inconclusive. This study aims to evaluate the associations between timing and frequency
Nephrology (Carlton). 2026 May;31(5):e70216. doi: 10.1111/nep.70216.ABSTRACTEosinophilic granulomatosis with polyangiitis (EGPA) is a rare ANCA-associated small-vessel vasculitis that may involve the peripheral nervous system. Although peripheral neuropathy is a common manifestation, acute symmetric
Vet Clin North Am Food Anim Pract. 2026 May 11:S0749-0720(26)00023-X. doi: 10.1016/j.cvfa.2026.03.009. Online ahead of print.ABSTRACTCongestive heart failure in feedlot cattle, once linked mainly to high-altitude brisket disease, is now increasingly recognized at moderate elevations as a distinct co
Nutr Metab Cardiovasc Dis. 2026 Apr 18:104761. doi: 10.1016/j.numecd.2026.104761. Online ahead of print.ABSTRACTBACKGROUND AND AIM: Cardiovascular-kidney-metabolic (CKM) syndrome is a disorder of growing global burden. This study aims to investigate the association between the hemoglobin-to-red cell
Nutr Metab Cardiovasc Dis. 2026 Apr 25:104773. doi: 10.1016/j.numecd.2026.104773. Online ahead of print.ABSTRACTBACKGROUND AND AIM: Remnant cholesterol (RC), lipoprotein(a) [Lp(a)], and inflammation are considered key residual cardiovascular risk (RCVR) factors. This study aimed to prospectively eva
Arch Bronconeumol. 2026 Apr 26:S0300-2896(26)00164-X. doi: 10.1016/j.arbres.2026.04.012. Online ahead of print.ABSTRACTOBJECTIVES: To prospectively evaluate the relationship between 4-year changes in lung function and the progression of subclinical atherosclerosis among 1623 middle-aged adults with
Heart. 2026 May 11:heartjnl-2025-327641. doi: 10.1136/heartjnl-2025-327641. Online ahead of print.ABSTRACTAthletes often exhibit a plethora of physiological changes that, on occasion, overlap with cardiac diseases that may cause sudden cardiac death (SCD). Several factors, such as age, sex and ethni
RMD Open. 2026 May 11;12(2):e006584. doi: 10.1136/rmdopen-2025-006584.ABSTRACTOBJECTIVE: To assess prevalence, associated disability and pain burden of the main rheumatic and musculoskeletal diseases (RMDs): rheumatoid and non-rheumatoid inflammatory arthritis, knee, hip and other peripheral joint o
BMJ Open. 2026 May 11;16(5):e120416. doi: 10.1136/bmjopen-2026-120416.ABSTRACTINTRODUCTION: Randomised clinical trials (RCTs) are gold standard in evidence-based medicine, but follow-up typically relies on clinic visits and trial-specific data collection. Much of this information overlaps with routi
BMJ Open. 2026 May 11;16(5):e111625. doi: 10.1136/bmjopen-2025-111625.ABSTRACTOBJECTIVES: This study examines the prevalence of and risk factors associated with cognitive impairment among Indian stroke survivors aged ≥60 using data from the Longitudinal Ageing Study in India (LASI).DESIGN: Cross-sec
