From nanoscale to clinic: The growing impact of nanotechnology in translational drug delivery

ADMET DMPK. 2026 Jul 27;14:3495. doi: 10.5599/admet.3495. eCollection 2026.ABSTRACTBACKGROUND AND PURPOSE: From the early use of liposomes in the 1960s to modern nucleic acid delivery platforms, nanotechnology has shown its value in drug delivery and diagnostic applications. A wide range of nanostru

R Ronny Vargas

Comprehensive review of biosynthesis, plant function, metabolism and new therapeutic bioactivities of flavonoids

ADMET DMPK. 2026 Jul 7;14:3404. doi: 10.5599/admet.3404. eCollection 2026.ABSTRACTBACKGROUND AND PURPOSE: Flavonoids are polyphenolic secondary metabolites synthesized via the phenylpropanoid pathway, serving as a vital biological "immune system" for plants by providing UV-B protection, antimicrobia

I Iman Permana Maksum

Assessment of the Prevalence of Hypertension and Its Associated Risk Factors in a Rural Community in Gwalior District, India

Cureus. 2026 Jul 23;18(7):e113238. doi: 10.7759/cureus.113238. eCollection 2026 Jul.ABSTRACTBACKGROUND: Hypertension is a major non-communicable disease and a leading contributor to cardiovascular morbidity and mortality. Its burden is increasing in rural India due to rapid lifestyle and epidemiolog

B Bishwajeet Thakur

Explainable Machine Learning for Predicting Deep Vein Thrombosis in Critically Ill Patients with COPD: Development and Multicenter External Validation

Int J Chron Obstruct Pulmon Dis. 2026 Aug 18;21:609203. doi: 10.2147/COPD.S609203. eCollection 2026.ABSTRACTBACKGROUND: Deep vein thrombosis (DVT) is a frequent yet underrecognized complication in critically ill patients with chronic obstructive pulmonary disease (COPD). Existing risk assessment too

G Guangdong Wang

Obesity at antiretroviral therapy initiation and long-term risk of cardiovascular disease, cancer, or death in people with HIV in Italy: a prospective cohort study

EClinicalMedicine. 2026 Aug 15;99:104150. doi: 10.1016/j.eclinm.2026.104150. eCollection 2026 Sep.ABSTRACTBACKGROUND: Altered adipose tissue biology plays a key role in the development of cardiovascular disease (CVD) and cancer and contributes to mortality. We assessed the association between obesit

C Cristina Mussini

Research advances in microneedle-exosome delivery systems for the treatment of multisystem diseases

Regen Ther. 2026 Aug 15;33:101166. doi: 10.1016/j.reth.2026.101166. eCollection 2026 Dec.ABSTRACTThe combined application of microneedles (MNs) and exosomes represents a significant research direction in the fields of targeted drug delivery and regenerative medicine. Their synergistic and complement

Z Zeng-En Jin

Association between psychiatric comorbidities and the pharmacological secondary prevention of ischemic heart disease and cerebrovascular disease - an analysis of real-world health insurance prescription data in Germany

Int J Cardiol Cardiovasc Risk Prev. 2026 Jul 31;30:200690. doi: 10.1016/j.ijcrp.2026.200690. eCollection 2026 Sep.ABSTRACTBACKGROUND: Individuals with mental disorders face substantially reduced life expectancy, with cardiovascular disease (CVD) as the leading cause of premature death, likely due to

S Sönke Johann Peters

Diagnostic Approach to Seronegative Autoimmune-Mediated Rhabdomyolysis: A Case Report

Cureus. 2026 Jul 23;18(7):e113239. doi: 10.7759/cureus.113239. eCollection 2026 Jul.ABSTRACTRhabdomyolysis is a potentially life-threatening condition caused by acute skeletal muscle injury leading to myocyte destruction and release of intracellular contents. While trauma and medications are common

C Cyrus Behzadi

Identifying High-Priority Profiles for Edentulism and Other Health Outcomes Through Population-Based Clustering

AJPM Focus. 2026 May 1;5(5):100505. doi: 10.1016/j.focus.2026.100505. eCollection 2026 Oct.ABSTRACTINTRODUCTION: The aim of this study was to create meaningful clusters of individuals with similar features at the start of the study and to link these clusters to the rate of complete edentulism. These

M Marjorie A Rosenberg

Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming

Bioact Mater. 2026 Aug 14;67:458-476. doi: 10.1016/j.bioactmat.2026.06.010. eCollection 2027 Jan.ABSTRACTMyocardial infarction (MI) is characterized by severe oxidative stress, excessive inflammation, and profound mitochondrial dysfunction. Although mitochondrial transplantation offers therapeutic p

H Hang Li

Alpha-1 antitrypsin deficiency associated with increased risk of venous thromboembolism: a nationwide cohort study in Denmark

Res Pract Thromb Haemost. 2026 Jul 13;10(5):106827. doi: 10.1016/j.rpth.2026.106827. eCollection 2026 Jul.ABSTRACTBACKGROUND: Mechanistic investigations suggest that alpha-1 antitrypsin may influence hemostatic processes; however, whether alpha-1 antitrypsin deficiency is associated with an elevated

S Sine Voss David

Gut Microbiota Associated With Hyperlipidemia: A Systematic Review and Meta-Analysis

Gastro Hep Adv. 2026 Jul 20;5(10):101067. doi: 10.1016/j.gastha.2026.101067. eCollection 2026.ABSTRACTBACKGROUND AND AIMS: Hyperlipidemia (HLD) is a major risk factor for cardiovascular disease. Increasing evidence suggests that gut microbiota may influence lipid metabolism, although findings remain

C Chai Xian Hua

Left Ventricular Thrombus Despite Prescribed Direct Oral Anticoagulant Therapy in Chronic Heart Failure With Reduced Ejection Fraction: A Case Report and Review of Risk Stratification

Cureus. 2026 Jul 23;18(7):e113208. doi: 10.7759/cureus.113208. eCollection 2026 Jul.ABSTRACTLeft ventricular thrombus (LVT) remains a clinically important complication associated with increased risks of systemic thromboembolism, ischemic stroke, and adverse cardiovascular outcomes. The optimal durat

G Gemechu Ayana

The prognostic value of combined TyG and SIRI categories for cardiovascular disease and all-cause mortality among adults: Evidence from the NHANES 1999-2010

Am Heart J Plus. 2026 Aug 6;70:100857. doi: 10.1016/j.ahjo.2026.100857. eCollection 2026 Oct.ABSTRACTBACKGROUND: The triglyceride-glucose (TyG) index and Systemic Inflammatory Response Index (SIRI) are markers of insulin resistance and inflammation, respectively, and are each independently associate

Y Yan Liu

Clinical Correlates of Hospital Admission in Adult SLE Patients Presenting to the Emergency Department

Am J Med Open. 2026 Jun 28;16:100137. doi: 10.1016/j.ajmo.2026.100137. eCollection 2026 Dec.ABSTRACTINTRODUCTION: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease frequently requiring emergency care. However, limited data exist on factors influencing hospital admission from the

N Neil Manadan

Protective effect and mechanism of SIRT1 under stress-induced vascular senescence

Open Life Sci. 2026 Aug 24;21(1):20251366. doi: 10.1515/biol-2025-1366. eCollection 2026 Jan.ABSTRACTA major focus of contemporary medical research is the primary pathological cardiovascular diseases, whereas stress-induced vascular senescence is a process with degenerative changes in vascular morph

K Kexin Wang

Multiomic Investigation of Shared Genetic Pathways in Paediatric Congenital Heart Disease and Neurodevelopmental Disorders

Hum Mutat. 2026 Aug 21;2026:7869246. doi: 10.1155/humu/7869246. eCollection 2026.ABSTRACTRecent medical advances have significantly improved the life expectancy of individuals with congenital heart disease (CHD); however, these children remain at increased risk of co-occurring neurodevelopmental dis

J Jamie-Lee M Thompson

Space radiation promotes clonal hematopoiesis and hematologic disease upon aging in a driver gene and sex-specific manner

iScience. 2026 Aug 12;29(8):116877. doi: 10.1016/j.isci.2026.116877. eCollection 2026 Aug 21.ABSTRACTThe effects of space radiation on clonal hematopoiesis (CH) and its impact on long-term health outcomes are unknown. Using male and female murine models of Trp53-, Ppm1d-, and Tet2-mediated CH, we ex

M Megan A Evans

Cost-effectiveness of early inclisiran for the secondary prevention of cardiovascular disease in Aboriginal and Torres Strait Islander Australians: A Markov modelling analysis

Int J Cardiol Cardiovasc Risk Prev. 2026 Aug 7;30:200687. doi: 10.1016/j.ijcrp.2026.200687. eCollection 2026 Sep.ABSTRACTBACKGROUND: Aboriginal and Torres Strait Islander Australians experience substantially higher rates of cardiovascular disease (CVD), premature mortality, and related healthcare ex

S Satyen Hargovan

A Study on the Clinical Phenotypes and Genetic Analysis of ENG Variants in Four Hereditary Hemorrhagic Telangiectasia Type 1 Families

Hum Mutat. 2026 Aug 21;2026:8307860. doi: 10.1155/humu/8307860. eCollection 2026.ABSTRACTBACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder primarily caused by pathogenic variants in the ENG gene, leading to clinical manifestations including pulmonary

Y Yujing Gong

Diagnosis and monitoring of metabolic dysfunction-associated steatohepatitis disease: a critical review

Crit Rev Clin Lab Sci. 2026 Aug 22:1-19. doi: 10.1080/10408363.2026.2716664. Online ahead of print.ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease worldwide and includes a spectrum ranging from simple steatosis to metabolic dysfu

E Elisa Marin-Couture

Variant Harmonization Critically Determines Polygenic Score Transferability for Lipid Traits in Samoan Populations

HGG Adv. 2026 Aug 22:100663. doi: 10.1016/j.xhgg.2026.100663. Online ahead of print.ABSTRACTDyslipidemia is a significant risk factor for cardiovascular disease (CVD), the leading cause of death in Samoa. Polygenic scores (PGS) for lipid traits offer promise for improved CVD risk prediction; however

T Toni-Ann J Yapp

Remnant cholesterol inflammation index (RCII) as a potential biomarker for ACPA-negative rheumatoid arthritis: evidence from dual-cohort analysis and serum lipidomics

Clin Rheumatol. 2026 Aug 22. doi: 10.1007/s10067-026-08228-2. Online ahead of print.ABSTRACTINTRODUCTION: Compared with anti-citrullinated protein autoantibody (ACPA)-positive RA, the etiology of ACPA-negative RA remains unclear, posing significant challenges to diagnosis. Recently, evidence has eme

Y Yuan-Yuan Liu

Spexin Attenuates Cerebral Ischemia-Reperfusion-Induced Brain Injury in Rats via Suppression of NF-κB-Associated Inflammation and Apoptosis

Mol Neurobiol. 2026 Aug 22;63(1):852. doi: 10.1007/s12035-026-06158-3.ABSTRACTCerebral ischemia-reperfusion (I/R) injury continues to be a significant factor contributing to neuronal loss and functional deficits subsequent to ischemic stroke, predominantly driven by oxidative stress, neuroinflammati

S Sevil Arabacı Tamer