World J Surg Oncol. 2025 Sep 17;23(1):336. doi: 10.1186/s12957-025-04007-6.ABSTRACTBACKGROUND: Frailty and sarcopenia are associated with adverse outcomes in multiple myeloma (MM), but their longitudinal changes and clinical relevance remain unclear. This study evaluated the longitudinal changes in
World J Surg Oncol. 2025 Sep 18;23(1):335. doi: 10.1186/s12957-025-03996-8.ABSTRACTAmino acid metabolic reprogramming has emerged as a pivotal mechanism underlying the pathogenesis of chronic airway diseases and lung cancer. This review comprehensively examines the dynamic regulation and clinical im
Genome Med. 2025 Sep 18;17(1):100. doi: 10.1186/s13073-025-01516-7.ABSTRACTBACKGROUND: Short-read genome sequencing (GS) is among the most comprehensive genetic testing methods available, capable of detecting single-nucleotide variants, copy-number variants, mitochondrial variants, repeat expansions
BMC Genom Data. 2025 Sep 17;26(1):64. doi: 10.1186/s12863-025-01360-z.ABSTRACTBACKGROUND: Olfactory dysfunction is among the earliest signs of many age-related neurodegenerative diseases and has been associated with increased mortality in older adults; however, its genetic basis remains largely unkn
J Cardiothorac Surg. 2025 Sep 17;20(1):351. doi: 10.1186/s13019-025-03567-8.ABSTRACTINTRODUCTION: Rapid deployment (RD) and sutureless (SU) aortic valve replacement (AVR) are established strategies with proven benefits and ongoing evolution. In this study, we compare the clinical results and technic
Respir Res. 2025 Sep 17;26(1):272. doi: 10.1186/s12931-025-03342-2.ABSTRACTBACKGROUND: Atrial fibrillation (AF) frequently occurs in patients with chronic obstructive pulmonary disease (COPD) and is associated with adverse clinical outcomes. We aimed to identify patients at risk for AF using amplifi
Nature. 2025 Sep 17. doi: 10.1038/s41586-025-09517-7. Online ahead of print.ABSTRACTBrown and beige adipocytes express uncoupling protein 1 (UCP1), a mitochondrial protein that dissociates respiration from ATP synthesis and promotes heat production and energy expenditure. However, UCP1-/- mice are n
Int J Cardiovasc Imaging. 2025 Sep 18. doi: 10.1007/s10554-025-03518-3. Online ahead of print.ABSTRACTINTRODUCTION: Hypertrophic Cardiomyopathy (HCM) is a genetic Heart disease characterized by myocardial hypertrophy, which can lead to Heart failure and fatal arrhythmias. The genetic basis of this c
EMBO Mol Med. 2025 Sep 17. doi: 10.1038/s44321-025-00311-6. Online ahead of print.ABSTRACTNon-structural protein 1 (NS1) of dengue virus (DENV) harbours two conserved N-glycosylation sites at positions 130 and 207, whose biological roles have remained elusive. Using a clinically relevant mouse model
Nat Med. 2025 Sep;31(9):2946-2957. doi: 10.1038/s41591-025-03614-w. Epub 2025 Sep 17.ABSTRACTA spinal cord injury (SCI) causes immediate and sustained hemodynamic instability that threatens neurological recovery and impacts quality of life. Here we establish the clinical burden of chronic hypotensiv
NPJ Precis Oncol. 2025 Sep 17;9(1):313. doi: 10.1038/s41698-025-01103-4.ABSTRACTIn medical oncology, text data, such as clinical letters or procedure reports, is stored in an unstructured way, making quantitative analysis difficult. Manual review or structured information retrieval is time-consuming
Signal Transduct Target Ther. 2025 Sep 18;10(1):311. doi: 10.1038/s41392-025-02411-8.ABSTRACTCalcification of the aortic valve is a prevalent cardiovascular pathology in the aging population. Traditionally linked to inflammation, lipid accumulation, and risk conditions, this disease remains poorly u
Zhen Ci Yan Jiu. 2025 Sept 25;50(9):1046-1054. doi: 10.13702/j.1000-0607.20240658.ABSTRACTOBJECTIVES: To observe the effect of "Huayu Tongluo"(blood stasis-removing and meridian-collateral dredging) moxibustion on oligodendrocyte-related protein expression and myelin ultrastructure in the corpus cal
Zhen Ci Yan Jiu. 2025 Sept 25;50(9):1037-1045. doi: 10.13702/j.1000-0607.20240287.ABSTRACTOBJECTIVES: To observe the effect of "Shugan Tiaoshen" needling (Smoothing the Liver and Regulating the Spirit) on antioxidant and lipid peroxidative stress in prefrontal cortex of rats with post-stroke depress
Br J Clin Pharmacol. 2025 Sep 17. doi: 10.1002/bcp.70289. Online ahead of print.ABSTRACTImmune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by platelet destruction. While most patients respond to first- or second-line therapies, a small subset is multirefractory. Fostamatinib,
J Natl Med Assoc. 2025 Sep 16:S0027-9684(25)00304-9. doi: 10.1016/j.jnma.2025.08.110. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the efficacy of sodium-glucose cotransporter-2 (SGLT2) inhibitors in reducing the risk of acute kidney injury (AKI) in patients with chronic kidney disease (CKD)
Transplant Proc. 2025 Sep 16:S0041-1345(25)00426-9. doi: 10.1016/j.transproceed.2025.06.020. Online ahead of print.ABSTRACTBACKGROUND: Human Leukocyte Antigen (HLA) genes play a crucial role in immune response against infectious disease. In this study, we aimed to investigate the frequency of HLA al
Zhongguo Dang Dai Er Ke Za Zhi. 2025 Sept 15;27(9):1140-1142. doi: 10.7499/j.issn.1008-8830.2503053.ABSTRACTA 14-year-old boy was admitted to the hospital due to a single episode of afebrile seizure and four hours of impaired consciousness. Three months prior to admission, he had a history of bilate
Zhongguo Dang Dai Er Ke Za Zhi. 2025 Sept 15;27(9):1119-1127. doi: 10.7499/j.issn.1008-8830.2504160.ABSTRACTOBJECTIVES: To investigate whether mesenchymal stem cell-derived exosomes (MSC-Exo) alleviate white matter damage (WMD) in neonatal rats by targeting the nucleotide-binding oligomerization dom
Klin Onkol. 2025;38(4):283-301. doi: 10.48095/ccko2025283.ABSTRACTBACKGROUND: TEMPI syndrome (telangiectasia, erythrocytosis with increased erythropoietin, monoclonal gammopathy, perinephritic fluid collections, and intrapulmonary shunts) was described by David Sykes in 2011. By the end of March 202
Klin Onkol. 2025;38(4):270-282. doi: 10.48095/ccko2025270.ABSTRACTBACKGROUND: Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid in the human body. Its therapeutic effects have been recognized in traditional Chinese medicine since ancient times and continue to be used i
Heart. 2025 Sep 17:heartjnl-2025-326376. doi: 10.1136/heartjnl-2025-326376. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Absolute risk estimates of long-term cardiovascular complications after atrial fibrillation (AF) diagnosis from contemporary cohorts are needed to guide clinical care. Quant
Ann Clin Lab Sci. 2025 Jul;55(4):585-589.ABSTRACTIntravascular fasciitis (IVF) is a rare, benign myofibroblastic proliferation involving arteries or veins that can mimic deep vein thrombosis (DVT). We report the first known case of IVF arising in the setting of May-Thurner syndrome (MTS), a congenit
Ann Clin Lab Sci. 2025 Jul;55(4):496-505.ABSTRACTOBJECTIVE: To determine the molecular mechanism of pulmonary ischemia-reperfusion (I/R) injury and seek effective therapeutic targets to reduce the incidence and mortality of pulmonary I/R injury.METHODS: Two models were established to explore the exp
