J Sleep Res. 2026 Jun 5:e70367. doi: 10.1111/jsr.70367. Online ahead of print.ABSTRACTInsomnia and obstructive sleep apnea (OSA) are common sleep disorders that often co-occur as comorbid insomnia and sleep apnea (COMISA), worsening health outcomes. This study characterized and compared the physiolo
Bipolar Disord. 2026 Jun;28(4):e70120. doi: 10.1111/bdi.70120.ABSTRACTOBJECTIVES: The heart-brain nexus is increasingly recognized as important for human health. Nonetheless, integration of this perspective in research and treatment remains limited in psychiatry, particularly in bipolar disorder (BD
Crit Care Explor. 2026 Jun 8;8(6):e1420. doi: 10.1097/CCE.0000000000001420. eCollection 2026 Jun 1.ABSTRACTIMPORTANCE: Evidence for prone positioning in post-cardiac surgery acute respiratory distress syndrome (ARDS), especially after acute type A aortic dissection (ATAAD) repair, is extremely limit
J Cardiothorac Surg. 2026 Jun 5. doi: 10.1186/s13019-026-04363-8. Online ahead of print.ABSTRACTBACKGROUND: Traumatic diaphragmatic hernia (TDH) may present months to years after blunt injury and can mimic biliary or pulmonary disease. Right-sided TDH is particularly prone to delayed recognition bec
BMC Med. 2026 Jun 5. doi: 10.1186/s12916-026-04976-9. Online ahead of print.ABSTRACTBACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a critical therapeutic target for managing hyperlipidemia and atherosclerosis. We developed Cadd4, a synthetic proteolysis-targeting chimera (PROTA
Brain. 2026 Jun 6:awag200. doi: 10.1093/brain/awag200. Online ahead of print.ABSTRACTWhite matter hyperintensities (WMHs) are the imaging hallmark of cerebral small vessel disease (SVD), yet their microstructural composition, spatial heterogeneity, and relationship to diffuse normal-appearing white
BMC Nephrol. 2026 Jun 5. doi: 10.1186/s12882-026-05090-x. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome has emerged as a major global health burden and driver of cardiovascular disease (CVD), the leading cause of death worldwide. Effective management of CKM
Lipids Health Dis. 2026 Jun 5. doi: 10.1186/s12944-026-02987-2. Online ahead of print.ABSTRACTBACKGROUND: Dyslipidemia, impaired glucose metabolism, and obesity are established cardiovascular disease (CVD) risk factors. Composite markers like the triglyceride-glucose (TyG) index reflect lipid quanti
BMC Cardiovasc Disord. 2026 Jun 5. doi: 10.1186/s12872-026-05967-7. Online ahead of print.ABSTRACTBACKGROUND: Farm workers experience some of the highest chronic pesticide exposures worldwide, yet potential links with key cardiovascular risk factors remain underexplored. This systematic review focus
BMC Plant Biol. 2026 Jun 6. doi: 10.1186/s12870-026-09082-9. Online ahead of print.ABSTRACTBACKGROUND: Angelica sinensis (Oliv.) Diels, a traditional Chinese herb widely used in food and medicine, predominantly grows in high-altitude regions under wild conditions. With the scarcity of wild resources
BMC Geriatr. 2026 Jun 5. doi: 10.1186/s12877-026-07769-0. Online ahead of print.ABSTRACTBACKGROUND: Limited data exist from low-income settings on the association between unintentional geriatric malnutrition and the risk of dementia. Our study investigated this association and stratified risk factor
J Intensive Care Med. 2026 Jun 5:8850666261456628. doi: 10.1177/08850666261456628. Online ahead of print.ABSTRACTObjectiveThis study aimed to compare the clinical efficacy of intravascular ultrasound (IVUS)-guided versus coronary angiography (CAG)-guided percutaneous coronary intervention (PCI) in p
Mol Med. 2026 Jun 5. doi: 10.1186/s10020-026-01517-1. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular diseases represent a primary cause of global mortality. Hydrogen sulfide operates as a major endogenous gasotransmitter that contributes to cardiovascular homeostasis through multiple bioch
Int J Obes (Lond). 2026 Jun 5. doi: 10.1038/s41366-026-02044-z. Online ahead of print.ABSTRACTOBJECTIVE: The association between the longitudinal trajectory changes of triglyceride-glucose (TyG) index and type 2 diabetes mellitus (T2DM) is still unclear among the population with normal weight; hence
Commun Biol. 2026 Jun 5. doi: 10.1038/s42003-026-09927-x. Online ahead of print.ABSTRACTImmune responses elicited by natural infection of the coronavirus SARS-CoV-2 (COVID-19) show significant heterogeneity in the magnitude and quality of memory T and B cell responses. However, little is known about
Sci Rep. 2026 Jun 5. doi: 10.1038/s41598-026-55708-1. Online ahead of print.ABSTRACTGiant cell arteritis (GCA) is one of the most common adult vasculitis. As large-scale studies on cardiovascular events in GCA are missing in France, our study examine their incidence using the French national medico-
Nat Commun. 2026 Jun 6. doi: 10.1038/s41467-026-73944-x. Online ahead of print.ABSTRACTEmerging SARS‑CoV‑2 variants and related zoonotic sarbecoviruses rely on ACE2 for cell entry, motivating host‑directed antivirals that block spike-ACE2 interaction. Here, we characterize MB‑32, a benzothiazole sma
Nat Commun. 2026 Jun 5. doi: 10.1038/s41467-026-74041-9. Online ahead of print.ABSTRACTThe limited real-world evidence on the clinical benefits of intensive blood pressure (BP) management demonstrated in randomised controlled trials has led to its poor adoption in primary care settings. Here we cond
Nat Commun. 2026 Jun 5. doi: 10.1038/s41467-026-74016-w. Online ahead of print.ABSTRACTLipid droplets (LDs), once viewed as inert lipid storage sites, are now recognised as dynamic organelles central to cellular signalling and immunity. This study presents a dual-omics approach, integrating proteomi
Signal Transduct Target Ther. 2026 Jun 5;11(1):217. doi: 10.1038/s41392-026-02768-4.ABSTRACTGalectins are glycan-binding proteins that interact with diverse glycoconjugates and protein networks to regulate intracellular and extracellular signaling pathways governing fundamental biological processes.
Nat Commun. 2026 Jun 5. doi: 10.1038/s41467-026-73026-y. Online ahead of print.ABSTRACTWhile air pollution is a recognized cardiovascular risk, its specific impact on aortic stenosis (AS) remains poorly characterized. This study investigates the association between air pollution and incident AS, int
Cell Death Dis. 2026 Jun 5. doi: 10.1038/s41419-026-08946-0. Online ahead of print.ABSTRACTToll-like receptors (TLRs) are central to host defense and tissue repair, yet dysregulated TLR signaling contributes to inflammatory and autoimmune diseases. Although core TLR pathways have been defined, the m
J Clin Lipidol. 2026 May 22:S1933-2874(26)00362-4. doi: 10.1016/j.jacl.2026.05.221. Online ahead of print.ABSTRACTBACKGROUND: Despite optimal lipoprotein cholesterol control, patients with chronic coronary syndrome (CCS) exhibit substantial residual cardiovascular risk. Lipoprotein(a) (Lp[a]) is an
J Clin Lipidol. 2026 May 20:S1933-2874(26)00148-0. doi: 10.1016/j.jacl.2026.05.010. Online ahead of print.ABSTRACTBACKGROUND: Familial hypercholesterolemia (FH) is a genetic condition that significantly increases the risk of coronary artery disease if left unmanaged. Although FH remains underdiagnos
