PIAS1 attenuates the progression of abdominal aortic aneurysm by stabilizing PPARγ through SUMOylation

Mol Immunol. 2026 May 7;195:61-72. doi: 10.1016/j.molimm.2026.04.018. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: Protein inhibitor of activated STAT 1 (PIAS1) functions as a SUMO E3 ligase, regulating cardiovascular diseases by promoting the SUMOylation of target proteins; however, its ro

H Haohua Wang

Oral Bioinspired Peroxisome-Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Adv Sci (Weinh). 2026 May 8:e19344. doi: 10.1002/advs.202519344. Online ahead of print.ABSTRACTAnthracyclines such as doxorubicin (DOX) are widely used in cancer chemotherapy but their clinical utility is severely limited by cumulative, dose-dependent, and largely irreversible cardiotoxicity. Mounti

S Shuyu Wang

Subtypes of Type 2 Diabetes and Prediabetes: Mortality and Excess Life Lost in South Asians

Diabetes Care. 2026 May 8:dc260043. doi: 10.2337/dc26-0043. Online ahead of print.ABSTRACTOBJECTIVE: Current definitions of type 2 diabetes (T2D) and prediabetes do not capture their pathophysiological heterogeneity. We investigated data-driven subtypes of T2D and prediabetes and evaluated their ass

R Ram Jagannathan

Pearls & Oy-sters: Stroke Recurrence After PFO Closure Uncovers Cerebrotendinous Xanthomatosis

Neurology. 2026 Jun 9;106(11):e218061. doi: 10.1212/WNL.0000000000218061. Epub 2026 May 8.ABSTRACTCerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive metabolic disorder that can cause premature atherosclerosis and ischemic stroke in young adults. We report a 23-year-old man who had re

L Lanyu Liu

Kidney dysfunction and pulmonary vascular disease in HFpEF: beyond association-time, congestion, and the limits of cross-sectional inference

No abstractEur J Heart Fail. 2026 May 8:xuag158. doi: 10.1093/ejhf/xuag158. Online ahead of print.NO ABSTRACTPMID:42102271 | DOI:10.1093/ejhf/xuag158

G Guillaume Baudry

Tailoring Implementation Strategies for the Acute Coronary Syndrome Quality Improvement Programme at Primary Care Level in East, West and Central China

Health Policy Plan. 2026 May 8:czag064. doi: 10.1093/heapol/czag064. Online ahead of print.ABSTRACTAcute coronary syndrome (ACS) remains a leading contributor to cardiovascular disease burden in China, and ST-segment elevation myocardial infarction (STEMI) is the most severe ACS. To improve early id

C Can Liu

Low cardiovascular event rates in patients treated with CAR T-cells: Real-world outcomes from two independent cohorts

ESC Heart Fail. 2026 May 8:xvag132. doi: 10.1093/eschf/xvag132. Online ahead of print.ABSTRACTAIMS: CAR-T cell therapy is becoming a key pillar of medical oncology, used for an expanding range of indications. Considering the increased risk of cardiovascular disease with increasing age, assessing the

J Jakob Christoph Voran

Post-Transbronchial Microwave Ablation Bronchopleural Fistula-A Case Series and Unique Insight

Eur J Cardiothorac Surg. 2026 Apr 1;68(Supplement_1):i68-i75. doi: 10.1093/ejcts/ezaf456.ABSTRACTOBJECTIVES: This case series aims to evaluate the incidence, mechanisms, and management of bronchopleural fistula (BPF) following transbronchial microwave ablation (TMWA) for lung tumours and to explore

A Aliss T C Chang

Beyond Tumour Size: The Impact of Spread Through Air Spaces and Pleural Invasion on Surgical Strategy for Early-Stage Non-Small Cell Lung Cancer

Eur J Cardiothorac Surg. 2026 Apr 1;68(Supplement_1):i50-i60. doi: 10.1093/ejcts/ezag084.ABSTRACTOBJECTIVES: To review the prognostic impact of spread through air spaces (STAS) and visceral pleural invasion (VPI) in early-stage non-small-cell lung cancer (NSCLC), assess their relevance to the increa

J Jiho Kwon

Neoadjuvant Chemoimmunotherapy Followed by Surgery for Non-Small Cell Lung Cancer: Current Evidence and Unmet Needs

Eur J Cardiothorac Surg. 2026 Apr 1;68(Supplement_1):i61-i67. doi: 10.1093/ejcts/ezaf471.ABSTRACTOBJECTIVES: Neoadjuvant chemoimmunotherapy (nCIT) has rapidly emerged as a transformative treatment strategy for resectable non-small cell lung cancer. This review summarizes current clinical evidence, s

H Hong Kwan Kim

Lymphadenectomy and Upstaging in Thoracic Oncology: A Narrative Review

Eur J Cardiothorac Surg. 2026 Apr 1;68(Supplement_1):i41-i49. doi: 10.1093/ejcts/ezag030.ABSTRACTOBJECTIVES: To review the historical evolution, current evidence, and future perspectives regarding lymphadenectomy in non-small-cell lung cancer (NSCLC), with a particular focus on its role in accurate

I Ilaria Ceccarelli

Association Between Pan-Immune-Inflammation Value and Mortality in Osteoarthritis: Evidence for Elevated Risk at Higher Levels

Mod Rheumatol. 2026 May 8:roag038. doi: 10.1093/mr/roag038. Online ahead of print.ABSTRACTOBJECTIVE: Systemic inflammation plays a key role in the progression of osteoarthritis (OA). The aim of this study was to explore the association of an emerging systemic inflammation marker, the pan-immune-infl

D Donghai Wang

FGF23 and Immune Cell Signatures Causally Linked to Subarachnoid Hemorrhage: Evidence From Multi-Omics and Genetic Colocalization

Brain Behav. 2026 May;16(5):e71485. doi: 10.1002/brb3.71485.ABSTRACTBACKGROUND: Inflammation and immune response significantly contribute to brain injury following subarachnoid hemorrhage (SAH), a severe neurological condition. This study employed Mendelian randomization, colocalization, and multi-o

X Xingjie Shi

Feasibility, acceptability, and fidelity evaluation of a contextualised physical activity and diet intervention for hypertension control in rural South African adults

PLoS One. 2026 May 8;21(5):e0348696. doi: 10.1371/journal.pone.0348696. eCollection 2026.ABSTRACTDespite the known benefits of physical activity and diet modifications for hypertension control, adults in rural South African settings still have high levels of uncontrolled hypertension. This paper out

K Kganetso Sekome

Variants in the DNAH11 gene responsible for primary ciliary dyskinesia or probably atypical primary ciliary dyskinesia presenting left-right asymmetry disorder

PLoS One. 2026 May 8;21(5):e0348352. doi: 10.1371/journal.pone.0348352. eCollection 2026.ABSTRACTPrimary ciliary dyskinesia (PCD) is a rare multi-system cilia-related disorder, and approximately 50% of individuals with PCD exhibit left-right asymmetry disorder. The dynein axonemal heavy chain 11 gen

K Kai Zhao

L-shaped relationship between hemoglobin glycation index and short-term mortality in patients with intracerebral hemorrhage: A retrospective cohort study

PLoS One. 2026 May 8;21(5):e0348436. doi: 10.1371/journal.pone.0348436. eCollection 2026.ABSTRACTBACKGROUND: Intracerebral hemorrhage (ICH) carries a substantial risk of early death and is frequently linked to unfavorable clinical outcomes, yet early prognostication remains challenging. The hemoglob

J Jia Xu

A modular deep learning architecture for interpretable disease prediction across tabular clinical and biometric datasets

PLoS One. 2026 May 8;21(5):e0348670. doi: 10.1371/journal.pone.0348670. eCollection 2026.ABSTRACTAccurate disease prediction using clinical datasets is essential for improving early diagnosis and clinical decision-support systems; however, many existing deep learning approaches are disease-specific,

V Vijay U Rathod

Neuromedin U mediates left atrial pressure-induced diuresis in the anaesthetised pig

PLoS One. 2026 May 8;21(5):e0348773. doi: 10.1371/journal.pone.0348773. eCollection 2026.ABSTRACTFinding a potential biomarker for elevated left atrial pressure would be clinically useful as a diagnostic for pre-heart failure. Therefore, an investigation into whether the protein neuromedin U (NMU),

V Vincent Healy

Machine learning-based model for predicting recanalization in isolated distal deep vein thrombosis and analysis of predictors

PLoS One. 2026 May 8;21(5):e0349110. doi: 10.1371/journal.pone.0349110. eCollection 2026.ABSTRACTBACKGROUND: Isolated distal deep vein thrombosis (IDDVT) is common, yet tools for predicting poor recanalization remain limited. We aimed to develop and compare machine learning models for predicting poo

Y Yingjie Kuang

Impact of socioeconomic status on one-year morbidity and readmission in patients with Takotsubo Syndrome: A Danish cohort study

Cardiology. 2026 May 8:1-21. doi: 10.1159/000551671. Online ahead of print.ABSTRACTTakotsubo Syndrome (TS) is a cardiac condition that mimics myocardial infarction (MI). Long-term readmission data remain limited. Previous studies in other conditions suggest that socioeconomic factors, such as low in

P Pernille Palm

Climate change and non-communicable diseases: An invisible syndemic

PLoS Med. 2026 May 8;23(5):e1005082. doi: 10.1371/journal.pmed.1005082. eCollection 2026 May.ABSTRACTClimate change accelerates non-communicable diseases (NCDs) through cascading environmental disruptions and is attributed to driving increased NCD-related mortality. Yet this syndemic remains invisib

G Gokul Parameswaran

Cyanotic Congenital Heart Disease in Pregnancy: A Comprehensive Review of Pathophysiology, Maternal-Fetal Outcomes, and Contemporary Management

Cardiol Rev. 2026 May 8. doi: 10.1097/CRD.0000000000001317. Online ahead of print.ABSTRACTAdvances in pediatric cardiac surgery and medical management have enabled an increasing number of women with cyanotic congenital heart disease to reach reproductive age and contemplate pregnancy. Maternal compl

K Kristjana Frangaj

A systematic literature search and narrative synthesis of economic drivers in hospitalizations for heart failure with preserved or mildly reduced ejection fraction in the United States

Am J Manag Care. 2026 May;32(6 Suppl):S95-S111. doi: 10.37765/ajmc.2026.89949.ABSTRACTBACKGROUND: Heart failure (HF) with mildly reduced ejection fraction (HFmrEF) or preserved EF (HFpEF) constitutes 74% of all HF cases in the US and is associated with significant clinical and economic burdens. Hosp

F Fiona Stewart

Management updates in heart failure with mildly reduced or preserved ejection fraction

Am J Manag Care. 2026 May;32(6 Suppl):S87-S94. doi: 10.37765/ajmc.2026.89948.ABSTRACTHeart failure (HF) is a clinical syndrome characterized by structural or functional impairments in ventricular filling or the ejection of blood from the heart. In the United States, HF represents a growing public he

J Jamie Grossman