Neurology. 2026 Jan 13;106(1):e214453. doi: 10.1212/WNL.0000000000214453. Epub 2025 Dec 5.ABSTRACTBACKGROUND AND OBJECTIVES: Cognitive impairment in older adults is influenced by coexisting β-amyloid (Aβ), tau, and cerebral small vessel disease (CSVD). Cerebral microbleeds (CMBs) are associated with
PLoS Comput Biol. 2025 Dec 5;21(12):e1013745. doi: 10.1371/journal.pcbi.1013745. eCollection 2025 Dec.ABSTRACTDiabetic retinopathy (DR) is a leading cause of vision impairment, which significantly impacts working-class populations, necessitating accurate and early diagnosis for effective treatment.
PLoS Comput Biol. 2025 Dec 5;21(12):e1013265. doi: 10.1371/journal.pcbi.1013265. eCollection 2025 Dec.ABSTRACTCardiac fibrosis is a pathological condition associated with many cardiovascular diseases. Atrial fibrosis leads to reduced atrial function, resulting in diminished blood flow and an increas
JMIR Cardio. 2025 Dec 5;9:e73747. doi: 10.2196/73747.ABSTRACTBACKGROUND: Telemedicine enables the provision of health services at a distance using information and communication technologies and includes different types of services: telemonitoring, remote control, virtual visit or televisit, telerefe
PLoS One. 2025 Dec 5;20(12):e0338025. doi: 10.1371/journal.pone.0338025. eCollection 2025.ABSTRACTINTRODUCTION: This study examines the correlation between creatine kinase (CK) and its muscle/brain isoenzyme (CK-MB) in relation to cardiovascular risk factors, highlighting sex disparities.METHODS: A
PLoS Med. 2025 Dec 5;22(12):e1004841. doi: 10.1371/journal.pmed.1004841. eCollection 2025 Dec.ABSTRACTBACKGROUND: Interferon (IFN) has been implicated in the pathogenesis of patients with systemic lupus erythematosus (SLE). However, its measurement in serum has been limited by low circulating levels
PLoS One. 2025 Dec 5;20(12):e0336675. doi: 10.1371/journal.pone.0336675. eCollection 2025.ABSTRACTBACKGROUND: In response to the escalating non-communicable disease (NCD) challenge, effective management of NCDs requires sustained investments in infrastructure, trained health workforce, and the consi
PLoS One. 2025 Dec 5;20(12):e0336338. doi: 10.1371/journal.pone.0336338. eCollection 2025.ABSTRACTBACKGROUND: The National Health and Nutrition Examination Survey (NHANES) is a nationwide program that evaluates the health and nutritional status of individuals in the United States. Chronic kidney dis
PLoS One. 2025 Dec 5;20(12):e0336139. doi: 10.1371/journal.pone.0336139. eCollection 2025.ABSTRACTBACKGROUND: Arteriosclerosis (AS) is a leading cause of cardiovascular disease, imposing significant burdens on families and society. However, the underlying mechanisms remain unclear. This study aims t
PLoS One. 2025 Dec 5;20(12):e0335935. doi: 10.1371/journal.pone.0335935. eCollection 2025.ABSTRACTBACKGROUND: There is a lack of research on the impact of hyperglycemia on the prognosis of patients with both chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD). This study ai
PLoS One. 2025 Dec 5;20(12):e0338208. doi: 10.1371/journal.pone.0338208. eCollection 2025.ABSTRACTProliferative diabetic retinopathy (PDR) is a microvascular complication of diabetes mellitus. Circular RNAs have been implicated in the pathogenesis of PDR. This study aimed to elucidate the specific m
J Allied Health. 2025 Winter;54(4):e551-e557.ABSTRACTBACKGROUND: Therapeutic hypothermia (TH) protects the infant's brain after hypoxic ischemic injury. Ongoing developmental therapies help support the brain recovery process. Currently, there is no standard of care for the involvement of therapists
Am J Physiol Endocrinol Metab. 2025 Dec 5. doi: 10.1152/ajpendo.00260.2025. Online ahead of print.ABSTRACTUCP1, a mitochondrial protein traditionally regarded as exclusive to thermogenic adipocytes, and Ucp1-promoter-driven Cre is widely used in gene manipulation in thermogenic adipocytes. However,
Wilderness Environ Med. 2025 Dec 5:10806032251395019. doi: 10.1177/10806032251395019. Online ahead of print.ABSTRACTAs the global population grows and access to remote environments expands, travel to high altitude destinations has become increasingly common, now attracting ∼100 million visitors annu
J Med Chem. 2025 Dec 5. doi: 10.1021/acs.jmedchem.5c02276. Online ahead of print.ABSTRACTPeptide therapeutics are rapidly emerging as a new drug modality, bridging the gap between small molecules and biologics to target diseases such as diabetes, cancer, and cardiovascular disorders. Despite their a
Cell Rep. 2025 Dec 4;44(12):116640. doi: 10.1016/j.celrep.2025.116640. Online ahead of print.ABSTRACTDysregulated cholesterol synthesis fuels cancer progression, but its precise role in hepatocellular carcinoma (HCC) remains unclear. Here, we identify elevated acetylation of 24-dehydrocholesterol re
Clin Appl Thromb Hemost. 2025 Jan-Dec;31:10760296251405419. doi: 10.1177/10760296251405419. Epub 2025 Dec 5.ABSTRACTBackgroundPortal venous thrombosis (PVT) is a serious complication in cirrhosis, with management debated due to differing anticoagulant guidelines. This network meta-analysis assessed
Clin Appl Thromb Hemost. 2025 Jan-Dec;31:10760296251405422. doi: 10.1177/10760296251405422. Epub 2025 Dec 5.ABSTRACTObjectiveTo analyze 180-day survival and associated factors in patients with chronic kidney disease (CKD) who initiated anticoagulation therapy during hospitalization.MethodsA survival
Am J Rhinol Allergy. 2025 Dec 5:19458924251404161. doi: 10.1177/19458924251404161. Online ahead of print.ABSTRACTBackgroundUltra-processed foods (UPF) are industrial formulations derived mostly from substances refined or extracted from foods. UPF intake has been linked to obesity, cardiovascular dis
Cancer Biomark. 2025 Dec;42(12):18758592251390251. doi: 10.1177/18758592251390251. Epub 2025 Dec 5.ABSTRACTPurposeVenous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a leading cause of morbidity and mortality in cancer patients. Prostate cancer is associated with
Asian Cardiovasc Thorac Ann. 2025 Dec 5:2184923251403903. doi: 10.1177/02184923251403903. Online ahead of print.ABSTRACTAnomalous aortic origin of a coronary artery (AAOCA) represents a rare yet clinically significant congenital anomaly associated with myocardial ischemia and sudden cardiac death, p
Ir J Med Sci. 2025 Dec 5. doi: 10.1007/s11845-025-04221-x. Online ahead of print.ABSTRACTINTRODUCTION: The estimated glomerular filtration rate (eGFR) calculated from serum creatinine has limitations in accurately reflecting kidney function due to its dependence on muscle mass and non-GFR determinan
Mol Neurobiol. 2025 Dec 5;63(1):256. doi: 10.1007/s12035-025-05558-1.ABSTRACTSubarachnoid hemorrhage (SAH) is a destructive subtype of stroke characterized by a high mortality and morbidity rate (45-50%) and a poor neurologic prognosis, encompassing both neurological and psychiatric impairments. It
Mol Cell Biochem. 2025 Dec 5. doi: 10.1007/s11010-025-05447-0. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is a comprehensive disease characterized by renal injury and decreased renal function, which can lead to increased cardiovascular and all cause mortality rates, seriously affecti
