J Gerontol A Biol Sci Med Sci. 2026 Jul 13:glag180. doi: 10.1093/gerona/glag180. Online ahead of print.ABSTRACTBiological age captures inter-individual heterogeneity in aging process arising from genetic and environmental influences. Metabolites, as the end-products of metabolism, integrate these fa
JAMA Netw Open. 2026 Jul 1;9(7):e2623260. doi: 10.1001/jamanetworkopen.2026.23260.ABSTRACTIMPORTANCE: Tenecteplase is an alternative to alteplase for intravenous thrombolysis in acute ischemic stroke given its simplified administration and comparable safety and efficacy. However, its impact on workf
Cochrane Database Syst Rev. 2026 Jul 13;7:CD013562. doi: 10.1002/14651858.CD013562.pub2.ABSTRACTRATIONALE: After inadequate response to first-line biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drug (DMARD) therapy in adults with rheumatoid arthritis, there are numerous altern
Cochrane Database Syst Rev. 2026 Jul 13;7:CD016366. doi: 10.1002/14651858.CD016366.ABSTRACTThis is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of different tumescent solutions for adults with lower limb varicose veins undergoing
Mol Cell Biochem. 2026 Jul 13. doi: 10.1007/s11010-026-05636-5. Online ahead of print.ABSTRACTOxidized low-density lipoprotein (ox-LDL) and inflammation cause endothelial dysfunction in coronary heart disease (CHD). Although ribosomal protein S5 (RPS5) has been linked to cardiovascular disease, the
Endocrine. 2026 Jul 13;91(1):226. doi: 10.1007/s12020-026-04698-1.ABSTRACTPURPOSE: To evaluate the metabolic dysregulation of patients with pheochromocytoma and their metabolic evolution after tumor resection.METHODS: This multicenter, retrospective study included individuals diagnosed and treated f
Drugs Real World Outcomes. 2026 Jul 13. doi: 10.1007/s40801-026-00568-4. Online ahead of print.ABSTRACTBACKGROUND: Rare cases of myocarditis and pericarditis following mRNA coronavirus disease-19 (COVID-19) vaccination have been reported, primarily among males under 30 years of age. Although the und
Geroscience. 2026 Jul 13. doi: 10.1007/s11357-026-02396-4. Online ahead of print.ABSTRACTBiological ageing is a heterogeneous process that shapes susceptibility to chronic disease. However, whether ageing patterns diverge within clinically defined type 2 diabetes (T2D) subgroups remains unclear. We
Endocrine. 2026 Jul 13;91(1):227. doi: 10.1007/s12020-026-04696-3.ABSTRACTPURPOSE: Obesity is a major global health crisis with rising prevalence in both pediatric and adult populations, leading to an increased risk of cardiovascular, metabolic, and other chronic complications affecting all organ sy
Echocardiography. 2026 Jul;43(7):e70551. doi: 10.1111/echo.70551.ABSTRACTCardiac shear wave elastography (SWE) is an emerging ultrasound-based technique that enables noninvasive assessment of myocardial mechanical properties beyond conventional motion- and deformation-based indices. By tracking the
J Cardiovasc Transl Res. 2026 Jul 13;19(1):90. doi: 10.1007/s12265-026-10809-0.ABSTRACTHeart failure (HF) is closely linked to mitochondrial dysfunction, featured by abnormal energy metabolism, excessive reactive oxygen species (ROS), and imbalanced mitochondrial dynamics. Clinically, effective targ
AIDS. 2026 Jun 16. doi: 10.1097/QAD.0000000000004569. Online ahead of print.ABSTRACTBACKGROUND: Hypertension is a leading contributor to cardiovascular disease in people with HIV (PWH), yet its underlying molecular mechanisms remain poorly understood.METHODS: We conducted a cross-sectional methylome
Endocr Rev. 2026 Jul 13:bnag022. doi: 10.1210/endrev/bnag022. Online ahead of print.ABSTRACTCardiovascular-kidney-metabolic (CKM) syndrome represents an intricate and interdependent nexus among metabolic risk factors, such as diabetes and obesity, chronic kidney disease (CKD), and cardiovascular dis
Acta Diabetol. 2026 Jul 13. doi: 10.1007/s00592-026-02743-z. Online ahead of print.ABSTRACTBACKGROUND: Progressive pancreatic β-cell dysfunction constitutes a hallmark of type 2 diabetes (T2D), yet the molecular programmes governing metabolic fitness deterioration remain incompletely characterised a
Diabetologia. 2026 Jul 13. doi: 10.1007/s00125-026-06795-2. Online ahead of print.ABSTRACTPeople with type 2 diabetes have a 60-70% higher risk of developing dementia than those without diabetes. Given the increasing number of older people living with diabetes, preventing dementia in this population
Wien Med Wochenschr. 2026 Jul 13. doi: 10.1007/s10354-026-01172-5. Online ahead of print.ABSTRACTIn the World Health Organization (WHO) 2022 classification of chronic myelomonocytic leukemia (CMML), the cutoff for absolute monocyte values was lowered from 1.0 × G/L (2016) to 0.5 × G/L to incorporate
Adv Ther. 2026 Jul 13. doi: 10.1007/s12325-026-03708-y. Online ahead of print.ABSTRACTINTRODUCTION: Titanium fastener technology is increasingly adopted for use in minimally invasive valve surgery and open procedures to facilitate faster operative times and reproducible fastening of sutures. The obj
FASEB J. 2026 Jul 31;40(14):e72112. doi: 10.1096/fj.202601304R.ABSTRACTThe activation of endoplasmic reticulum stress (ERS), specifically the PERK/eIF2α/CHOP signaling, is a recognized consequence of ischemic stroke. However, the roles and mechanisms of CRM-1 regulating ERS in stroke are poorly eluc
Diabetes Ther. 2026 Jul 13. doi: 10.1007/s13300-026-01889-x. Online ahead of print.ABSTRACTThe latest type 2 diabetes mellitus (T2DM) management guidelines from the UK National Institute for Health and Care Excellence (NICE; NG28) have raised the profile of sodium-glucose cotransporter-2 inhibitors
Endocrine. 2026 Jul 13;91(1):235. doi: 10.1007/s12020-026-04660-1.ABSTRACTOBJECTIVE: This study aimed to investigate the prognostic impact of thyroid function on the outcomes of patients with heart failure with mildly reduced ejection fraction (HFmrEF).BACKGROUND: Thyroid function is crucial for the
CEN Case Rep. 2026 Jul 13;15(4):119. doi: 10.1007/s13730-026-01159-6.ABSTRACTImmunotactoid glomerulopathy (ITG) is a rare glomerulonephritis characterized by the deposition of hollow-centered microtubular structures on electron microscopy (EM), and by IgG, C3, and restricted light chain deposition o
Transl Stroke Res. 2026 Jul 13;17(4):77. doi: 10.1007/s12975-026-01452-7.ABSTRACTMounting evidence reframes stroke not as a single cerebral event but as a dynamic brain-body network disorder. Extracellular vesicles (EVs)-lipid bilayer-enclosed particles released by virtually all cells-serve as inter
J Artif Organs. 2026 Jul 13;29(3):44. doi: 10.1007/s10047-026-01571-w.ABSTRACTWe report a rare device fracture during Impella 5.5 explantation for cardiogenic shock in a 77-year-old man with prolonged device support. Following stabilization, device removal was attempted on day 50. During withdrawal,
Neurosurg Rev. 2026 Jul 13;49(1):475. doi: 10.1007/s10143-026-04388-6.ABSTRACTFlow diverters (FDs) are emerging as a treatment strategy for superior cerebellar artery aneurysms (SCAs) despite the limited data on their efficacy and safety. This study evaluated flow diversion (FD) treatment for proxim
