Fibroblast-driven MMP-9/TIMP-1 imbalance in bronchoalveolar lavage reflects fibrotic progression in interstitial lung disease

Eur J Clin Invest. 2025 Dec 7:e70162. doi: 10.1111/eci.70162. Online ahead of print.ABSTRACTBACKGROUND: Interstitial lung diseases (ILDs) are characterized by progressive fibrosis, in which extracellular matrix remodelling is regulated by matrix metalloproteinases (MMPs) and their inhibitors (TIMPs)

M Maria Bertolotto

Improving CAR T cell therapy against malignancies through gene knock-down/out strategies: a systematic review

Cancer Cell Int. 2025 Dec 7. doi: 10.1186/s12935-025-04090-5. Online ahead of print.ABSTRACTBACKGROUND: CAR T cells still face numerous obstacles in treating hematologic and solid malignancies. Although gene editing technologies have improved CAR T cell therapy, there are currently no systematic rev

A Amirali Karimi

Sarcopenia risk along the cardiovascular-kidney-metabolic syndrome spectrum: synergistic effects of multisystem burden and physical inactivity

No abstractBMC Public Health. 2025 Dec 8. doi: 10.1186/s12889-025-25740-3. Online ahead of print.NO ABSTRACTPMID:41354917 | DOI:10.1186/s12889-025-25740-3

D Dingding Wang

The effect of different telerehabilitation technologies on the management of cardiovascular disease in oncology survivors: systematic review

J Cancer Surviv. 2025 Dec 8. doi: 10.1007/s11764-025-01951-w. Online ahead of print.ABSTRACTPURPOSE: With advancements in early detection and treatment improving cancer survival rates, cancer survivors face an increased risk of cardiovascular-specific morbidity and mortality. Cardiovascular telereha

N Nikkita Singh

Association of Average Glucose and Glycemic Variability With 28-Day Mortality in Patients With Cardiac Arrest: A Retrospective Study

J Diabetes. 2025 Dec;17(12):e70179. doi: 10.1111/1753-0407.70179.ABSTRACTBACKGROUND: Blood glucose levels and glycemic variability are associated with poor prognosis in critically ill patients. This study aims to investigate the relationship between average glucose (AG) and glycemic variability (GV)

Z Zhenyu Shan

Construction of risk factors and prediction model for arteriovenous graft thrombosis

Nefrologia (Engl Ed). 2025 Dec;45(10):501365. doi: 10.1016/j.nefroe.2025.501365.ABSTRACTOBJECTIVE: This study aims to identify risk factors for thrombosis in arteriovenous grafts and construct a predictive model to assess thrombosis risk in patients undergoing maintenance hemodialysis (MHD).METHODS:

Y Yumei Fang

Association of hemoglobin and red cell distribution width ratio with new cardiovascular events in peritoneal dialysis patients

Nefrologia (Engl Ed). 2025 Dec;45(10):501370. doi: 10.1016/j.nefroe.2025.501370.ABSTRACTOBJECTIVE: Peritoneal dialysis (PD) patients, who are more likely to have a poor prognosis for new cardiovascular events (CVE), are the focus of our research. We aim to investigate whether the hemoglobin-to-red c

R Rong Wei

Inotuzumab ozogamicin-associated sinusoidal obstruction syndrome/veno-occlusive disease diagnosed by transjugular liver biopsy

Rinsho Ketsueki. 2025;66(11):1467-1473. doi: 10.11406/rinketsu.66.1467.ABSTRACTA 75-year-old man diagnosed with Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia did not respond to standard induction chemotherapy, but was successfully treated with inotuzumab ozogamicin (InO). Alth

S Shunichiro Yasuda

A cohort study on cardiovascular diseases in adults with hemophilia: an interim subanalysis on comorbidities and medication from ADVANCE Japan

Rinsho Ketsueki. 2025;66(11):1438-1448. doi: 10.11406/rinketsu.66.1438.ABSTRACTINTRODUCTION: As life expectancy in hemophilia improves, chronic comorbidities and treatment-related challenges demand greater attention.OBJECTIVE: To characterize comorbidities, medication use, and cardiovascular risk fa

A Azusa Nagao

Importance of CALLY Scores in Predicting Coronary Artery Bypass Grafting Outcomes

Ann Thorac Cardiovasc Surg. 2025;31(1). doi: 10.5761/atcs.oa.25-00156.ABSTRACTPURPOSE: This study aimed to clarify the importance of C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index scores in predicting coronary artery bypass grafting (CABG) outcomes.METHODS: Patients were divided into quar

H Hakkı Kursat Cetin

Clustering of patients with severe asthma based on long-term FEV1% changes: Real-world evidence

Ann Allergy Asthma Immunol. 2025 Dec 5:S1081-1206(25)01371-7. doi: 10.1016/j.anai.2025.12.002. Online ahead of print.ABSTRACTBACKGROUND: Severe asthma is a heterogeneous disease with variable clinical manifestations and treatment responses. Long-term assessment of lung function trajectories may help

Y Youngsoo Lee

Re-Analyzing Value Assessments in AHA Clinical Practice Guidelines Using Health Years in Total Instead of QALYs

Value Health. 2025 Dec 5:S1098-3015(25)06150-9. doi: 10.1016/j.jval.2025.11.012. Online ahead of print.ABSTRACTOBJECTIVES: This study aims to re-perform cost-effective analyses (CEAs) that informed American Heart Association (AHA) guidelines between 2014-2022 using the health years in total (HYT) in

J Jihye Han

Persistent Attenuation of Lymphocyte Subsets After Mass SARS-CoV-2 Infection

Int J Infect Dis. 2025 Dec 5:108287. doi: 10.1016/j.ijid.2025.108287. Online ahead of print.ABSTRACTOBJECTIVES: Growing evidence suggests that lymphocyte subsets are declined in COVID-19 patients, but it is unclear if these alterations persist after widespread exposure to SARS-CoV-2 or how long they

Z Zhengqi Jiang

Artificial Intelligence-based prediction of Cardiothoracic Intensive Care Unit length of stay: a comparative machine learning approach

J Thorac Cardiovasc Surg. 2025 Dec 5:S0022-5223(25)01041-4. doi: 10.1016/j.jtcvs.2025.11.020. Online ahead of print.ABSTRACTOBJECTIVE: Predicting prolonged intensive care unit (ICU) length of stay (LOS) remains challenging, and traditional statistical models often fail to capture patient's complexit

R Rafael Maniés Pereira

Cardiovascular effects of metformin and testosterone replacement therapy in older men with hormone-related cancers and cancer-free population

Ann Epidemiol. 2025 Dec 5:S1047-2797(25)00352-7. doi: 10.1016/j.annepidem.2025.12.004. Online ahead of print.ABSTRACTPURPOSE: This study examines the association between use of metformin and testosterone replacement therapy (TTh) with risk of cardiovascular disease (CVD) and its subcategories in the

O Omer Abdelgadir

Metabolomic Signature of RV-PA Coupling Differentiates Haemodynamic Response to Imatinib Therapy in Pulmonary Arterial Hypertension

J Heart Lung Transplant. 2025 Dec 5:S1053-2498(25)02413-1. doi: 10.1016/j.healun.2025.11.024. Online ahead of print.ABSTRACTBACKGROUND: Right ventricular (RV) dysfunction is the leading cause of mortality in pulmonary arterial hypertension (PAH). Although RV metabolic remodelling in chronic pressure

L Lars Harbaum

Cysteine Cathepsins and Drug Discovery: Knowns and Unknowns

Biochemistry (Mosc). 2025 Nov;90(11):1757-1763. doi: 10.1134/S0006297925602205.ABSTRACTCysteine cathepsins are a group of closely related proteolytic enzymes active at low pH. The most well-studied function of these enzymes is protein degradation within lysosomes. However, accumulating evidence sugg

A Andrey A Zamyatnin

Building and validating a machine learning model to predict coronary heart disease risk based on non-invasive indicators

Comput Methods Programs Biomed. 2025 Nov 30;275:109186. doi: 10.1016/j.cmpb.2025.109186. Online ahead of print.ABSTRACTBACKGROUND: Coronary heart disease (CHD) remains a leading global cause of death. Early identification of high-risk individuals and timely intervention are crucial. This study devel

B Bo Wu

Placental vascular abnormality is associated with worse neurodevelopmental outcomes for infants with congenital heart disease and genetic abnormality

Early Hum Dev. 2025 Nov 25;213:106456. doi: 10.1016/j.earlhumdev.2025.106456. Online ahead of print.ABSTRACTOBJECTIVE: Determine the association of placental vascular abnormality with neurodevelopment (ND) in toddlers with congenital heart disease (CHD) requiring intervention with cardiopulmonary by

K Kelly L Meyer

Global Sirt5 deletion reshapes gut microbiota and impairs glucose metabolism in high-fat diet-induced obese mice

Biochem Biophys Res Commun. 2025 Dec 3;795:153095. doi: 10.1016/j.bbrc.2025.153095. Online ahead of print.ABSTRACTDefects in sirtuins (SIRTs) signaling contribute to disrupted glycolipid metabolism, resulting in obesity, type 2 diabetes (T2D) and other metabolic diseases. Sirtuin 5 (Sirt5) has been

H Hui Cao

Radiofrequency ablation of persistent atrial fibrillation in a patient with dextrocardia and interruption of inferior vena cava in the fluoroless catheterization laboratory: a case report

J Med Case Rep. 2025 Dec 7. doi: 10.1186/s13256-025-05719-9. Online ahead of print.ABSTRACTBACKGROUND: Catheter ablation is an established therapy for atrial fibrillation, yet its application in patients with complex congenital cardiovascular anomalies remains challenging. Dextrocardia (1-2/20,000 i

Z Zhou Du

Dapagliflozin in acute heart failure: lessons from the DAPA ACT HF-TIMI 68 trial

No abstractHeart Fail Rev. 2025 Dec 8;31(1):10. doi: 10.1007/s10741-025-10572-5.NO ABSTRACTPMID:41354894 | DOI:10.1007/s10741-025-10572-5

J Jenna Skowronski

Assessing hypertension knowledge and its association with sociodemographic variables among hypertensive patients in Bangladesh

Sci Rep. 2025 Dec 7. doi: 10.1038/s41598-025-17415-1. Online ahead of print.ABSTRACTThe purpose of this research is to analyze the relationship between sociodemographic factors and hypertension knowledge among hypertensive patients in Bangladesh. By identifying key determinants of awareness, the stu

A Abul Kalam

Prevalence and influencing factors of kinesiophobia in patients with acute myocardial infarction after emergency percutaneous coronary intervention

No abstractCurr Probl Surg. 2025 Dec;73:101899. doi: 10.1016/j.cpsurg.2025.101899. Epub 2025 Sep 26.NO ABSTRACTPMID:41354495 | DOI:10.1016/j.cpsurg.2025.101899

W Wenquan Qu