Cardiol Rev. 2025 Nov 20. doi: 10.1097/CRD.0000000000001131. Online ahead of print.ABSTRACTMarfan syndrome is a multisystem connective tissue condition that results in extracellular matrix breakdown and dysregulated transforming growth factor-beta signaling caused by FBN1 mutations. The principal fo
Biopsychosoc Sci Med. 2025 Nov 10. doi: 10.1097/PSY.0000000000001449. Online ahead of print.ABSTRACTOBJECTIVE: Examine the association between types of childhood maltreatment and surrogate markers of vascular function, and to test whether sex modify these relationships.METHODS: Childhood maltreatmen
Cardiol Rev. 2025 Nov 20. doi: 10.1097/CRD.0000000000001134. Online ahead of print.ABSTRACTThe management of patients with concomitant coronary artery disease and carotid artery stenosis undergoing coronary artery bypass grafting (CABG) remains controversial. While synchronous carotid endarterectomy
Am J Physiol Heart Circ Physiol. 2025 Nov 26. doi: 10.1152/ajpheart.00644.2025. Online ahead of print.ABSTRACTAdverse conditions within the embryonic environment can alter embryogenesis, programming systemic physiological changes that may manifest as disease states in adult life. The process of deve
Can J Microbiol. 2025 Nov 26. doi: 10.1139/cjm-2025-0075. Online ahead of print.ABSTRACTAtherosclerotic Cardiovascular Disease (ASCVD) is a global health concern, leading to higher rates of morbidity and mortality. Gut microbial dysbiosis significantly contributes to obesity related ASCVD. However t
JMIR Cardio. 2025 Nov 26;9:e76275. doi: 10.2196/76275.ABSTRACTBACKGROUND: Effective hypertension management, particularly through self-care strategies, remains a significant public health challenge. Despite widespread awareness, only approximately 1 in 5 adults achieves adequate blood pressure (BP)
N Engl J Med. 2025 Nov 27;393(21):2131-2141. doi: 10.1056/NEJMoa2504411.ABSTRACTBACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) can cause recurrent, severe epistaxis, as well as anemia and reduced quality of life. The disease remains without licensed therapies worldwide.METHODS: In this proo
J Invasive Cardiol. 2025 Nov 25. doi: 10.25270/jic/25.00304. Online ahead of print.ABSTRACTOBJECTIVES: Leadless pacemakers provide an alternative to transvenous pacing in patients at risk for lead- and pocket-related complications. While the femoral vein is the standard route of implantation, certai
Aging Dis. 2025 Nov 9. doi: 10.14336/AD.2025.1108. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) have long been the leading cause of mortality among the elderly worldwide. Despite substantial progress, a complete understanding of the initiation and progression of CVDs remains elusive.
Aging Dis. 2025 Nov 16. doi: 10.14336/AD.2025.0976. Online ahead of print.ABSTRACTEndothelial senescence is a critical contributor of arterial dysfunction and age-related cardiovascular diseases. This study demonstrates that long-term senolytic treatment with dasatinib plus quercetin (D+Q; 5 mg/kg +
Aging Dis. 2025 Nov 21. doi: 10.14336/AD.2025.0871. Online ahead of print.ABSTRACTChronic systemic inflammation in the elderly is a hallmark of aging and a major contributor to age-related diseases. It both results from and promotes the accumulation of senescent immune cells. While the sex differenc
J Virol. 2025 Nov 26:e0065725. doi: 10.1128/jvi.00657-25. Online ahead of print.ABSTRACTRIG-I like receptors (RLRs) recognize RNA viruses and induce an innate immune response. Although many host factors strictly regulate the signal transduction of the RLR pathway, the mechanisms remain unclear. In t
Eur Heart J Cardiovasc Imaging. 2025 Nov 26:jeaf332. doi: 10.1093/ehjci/jeaf332. Online ahead of print.ABSTRACTStress imaging in paediatric cardiology and congenital heart disease patients has an increasing role for functional assessment. Indications include coronary artery anomalies and disease in
PLoS One. 2025 Nov 26;20(11):e0336499. doi: 10.1371/journal.pone.0336499. eCollection 2025.ABSTRACTBACKGROUND: The China National Stroke Screening Surveys (CNSSS), a decade-long national public health initiative, aims to reduce stroke morbidity and mortality through early detection and intervention.
Cardiovasc Res. 2025 Nov 26:cvaf252. doi: 10.1093/cvr/cvaf252. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is an established risk factor for multiple cardiovascular diseases including atrial fibrillation (AF). The causal relationship between type 1 diabetes (T1D) and AF is poorly defined. T1
PLoS One. 2025 Nov 26;20(11):e0337601. doi: 10.1371/journal.pone.0337601. eCollection 2025.ABSTRACTBACKGROUND: Microglia polarization plays a crucial role in the progression of cerebral ischemia-reperfusion injury (CIRI), but the mechanisms remain largely undefined. The preset study aimed to investi
Endocrinol Diabetes Metab. 2025 Nov;8(6):e70134. doi: 10.1002/edm2.70134.ABSTRACTBACKGROUND: Obesity represents a major global health challenge, contributing substantially to cardiovascular disease and metabolic complications. Orforglipron, a novel oral non-peptide GLP-1 receptor agonist, has emerge
Proc Natl Acad Sci U S A. 2025 Dec 2;122(48):e2517531122. doi: 10.1073/pnas.2517531122. Epub 2025 Nov 26.ABSTRACTThe activation of blood monocytes and the infiltration of monocyte-derived macrophages into the vessel walls are the central part of atherosclerosis. However, the mechanisms underlying th
PLoS One. 2025 Nov 26;20(11):e0333057. doi: 10.1371/journal.pone.0333057. eCollection 2025.ABSTRACTBACKGROUND: Thyroid hormone sensitivity has emerged as a critical factor in various diseases. However, its relationship with ischemic stroke-associated pneumonia (iSAP) in euthyroid patients with ische
PLoS One. 2025 Nov 26;20(11):e0335412. doi: 10.1371/journal.pone.0335412. eCollection 2025.ABSTRACTCalcium and magnesium both work together and against each other by sharing homeostatic regulatory systems in the kidneys. Previous studies suggested that these minerals and their intake ratio were asso
J Infect Dis. 2025 Nov 26:jiaf594. doi: 10.1093/infdis/jiaf594. Online ahead of print.ABSTRACTOBJECTIVES: Vascular graft or endograft infections (VGEI) pose a detrimental complication when using vascular grafts and are challenging to diagnose and treat. This study examined the progression of infecti
J Cardiovasc Med (Hagerstown). 2025 Nov 1;26(11):666-673. doi: 10.2459/JCM.0000000000001799. Epub 2025 Sep 26.ABSTRACTIron deficiency is a highly prevalent and clinically significant comorbidity in patients with heart failure, occurring in up to 80% of acute heart failure and over 50% of chronic hea
J Cardiovasc Med (Hagerstown). 2025 Nov 1;26(11):656-665. doi: 10.2459/JCM.0000000000001800. Epub 2025 Sep 26.ABSTRACTBACKGROUND: Transthyretin cardiac amyloidosis (ATTR-CA) typically manifests with heart failure. Discontinuing beta-blockers and avoiding angiotensin-converting enzyme inhibitors/angi
J Cardiovasc Med (Hagerstown). 2025 Nov 1;26(11):649-655. doi: 10.2459/JCM.0000000000001797. Epub 2025 Oct 29.ABSTRACTAIM: The distinctive feature of the analgesia induced by morphine is the profound pain relieving combined with the lack of loss of consciousness. We evaluated the impact of the use o
