Cardiovascular and Metabolic Outcomes of Hormone Replacement Therapy in Women Aged 65 Years and Older: A Systematic Review of Randomized Clinical Trials

Clin Pharmacol. 2026 Sep 9;18:581397. doi: 10.2147/CPAA.S581397. eCollection 2026.ABSTRACTBACKGROUND: The cardiovascular, kidney, and metabolic effects of hormone replacement therapy (HRT) in postmenopausal women, particularly those who initiate treatment after age 65, remain incompletely characteri

T Taraneh Mousavi

Mean Platelet Volume and Mean Platelet Volume-to-Platelet Ratio and Their Association With Mortality in Patients Undergoing Maintenance Hemodialysis

Cureus. 2026 Aug 14;18(8):e114527. doi: 10.7759/cureus.114527. eCollection 2026 Aug.ABSTRACTIntroduction Patients receiving maintenance hemodialysis (HD) remain at high risk of cardiovascular morbidity and mortality despite advances in dialysis therapy. The mean platelet volume (MPV) reflects platel

D Diana D Nenova

Immune senescence and exhaustion in breast cancer patients with a history of childhood maltreatment

Brain Behav Immun Health. 2026 Aug 31;56:101345. doi: 10.1016/j.bbih.2026.101345. eCollection 2026 Oct.ABSTRACTPURPOSE: Child maltreatment has lasting adverse effects on both physical and mental health and is associated with reduced quality of life. In Colombia, this problem remains highly prevalent

I Ivon Johanna Rodríguez-Rodríguez

Autoimmune-associated thrombosis: mechanisms, population burden, and prevention strategies

Lancet Reg Health Eur. 2026 Sep 3;70:101850. doi: 10.1016/j.lanepe.2026.101850. eCollection 2026 Nov.ABSTRACTAutoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, and systemic vasculitis, are associated with increased risk of thrombosis, accele

D Deepa J Arachchillage

Early mineralocorticoid receptor antagonism for end-organ protection in hypertension: Implications for disparities and rethinking the timing paradigm

Dialogues Health. 2026 Aug 19;9:100343. doi: 10.1016/j.dialog.2026.100343. eCollection 2026 Dec.ABSTRACTPURPOSE: Hypertension-related end-organ damage disproportionately affects Black populations, with earlier onset, greater severity, and higher rates of heart failure and chronic kidney disease desp

C Camellus O Ezeugwu

Nanoparticle-Based Therapeutic Strategies for Pathological Cardiac Hypertrophy: Preclinical Advances, Translational Challenges, and Future Perspectives

Int J Nanomedicine. 2026 Sep 9;21:619643. doi: 10.2147/IJN.S619643. eCollection 2026.ABSTRACTPathological cardiac hypertrophy is a major contributor to heart failure and is characterized by complex molecular mechanisms involving transcriptional and epigenetic regulation, signal transduction, metabol

M Mengyue Yang

Long-term subclinical cardiac damage in people living with human immunodeficiency virus

Int J Cardiol Heart Vasc. 2026 Sep 3;66:102007. doi: 10.1016/j.ijcha.2026.102007. eCollection 2026 Oct.ABSTRACTINTRODUCTION: Human immunodeficiency virus (HIV) infection remains a major global health challenge. People living with HIV are twice as likely to develop cardiovascular disease. Myocardial

J Julia Gómez-Diego

Outcomes after cervical transforaminal epidural steroid injections vs cervical interlaminar epidural steroid injections: A propensity matched comparison study utilizing a large national database

Interv Pain Med. 2026 Sep 3;5(3):100811. doi: 10.1016/j.inpm.2026.100811. eCollection 2026 Sep.ABSTRACTBACKGROUND: Cervical transforaminal and interlaminar epidural steroid injections (CTFESI and CILESI) are commonly used to treat cervical radicular symptoms. There is limited literature comparing th

A Andrew R Stephens

Associations of Growth Differentiation Factor 15 in Chronic Kidney Disease

Kidney Int Rep. 2026 Jul 30;11(10):106995. doi: 10.1016/j.ekir.2026.106995. eCollection 2026 Oct.ABSTRACTINTRODUCTION: Anorexia is common in chronic kidney disease (CKD), yet the underlying mechanisms remain poorly defined. Growth differentiation factor-15 (GDF-15) suppresses appetite in cancer, whe

T Thomas McDonnell

Comprehensive Advances in General Medicine and Trauma Emergency Care: Integrating Surgery, Internal Medicine, and Lifestyle Medicine for Holistic Patient Management

Cureus. 2026 Aug 13;18(8):e114510. doi: 10.7759/cureus.114510. eCollection 2026 Aug.ABSTRACTEmergency and trauma care increasingly involves patients with overlapping acute pathology, chronic disease, frailty, infection risk, functional limitation, and modifiable cardiometabolic factors. Although res

N Nametha Singh Jayasingh

Single nucleus transcriptomics reveals ITGA8-driven fibroblast remodeling in rheumatic valvular atrial fibrillation

iScience. 2026 Sep 1;29(9):117310. doi: 10.1016/j.isci.2026.117310. eCollection 2026 Sep 18.ABSTRACTAtrial fibrillation (AF) associated with rheumatic valvular disease involves complex cellular remodeling of the atrial myocardium. Here, single-nucleus RNA sequencing of left atrial tissues from healt

J Jinjin Wu

Insulin resistance increases the risk of conversion to the subcortical small vessel type of dementia

Cereb Circ Cogn Behav. 2026 Aug 27;11:100561. doi: 10.1016/j.cccb.2026.100561. eCollection 2026.ABSTRACTBACKGROUND: Insulin resistance (IR) has been associated with cognitive impairment and white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) in population-based studies. However,

E Elin Axelsson Andrén

C-reactive protein and incidence of symptomatic peripheral vascular disease (sPVD): Findings from the multi-ethnic study of atherosclerosis (MESA)

Am Heart J Plus. 2026 Aug 27;70:100872. doi: 10.1016/j.ahjo.2026.100872. eCollection 2026 Oct.ABSTRACTEarly identification of individuals at risk for symptomatic peripheral vascular disease (sPVD), including abdominal aortic aneurysm (AAA) and peripheral artery disease (PAD), is essential to reduce

A Atef Akoum

Feasibility and safety of a standardized low-dose thrombolytic therapy for right-sided mechanical prosthetic valve thrombosis in adult congenital heart disease

Int J Cardiol Congenit Heart Dis. 2026 Aug 12;25:100707. doi: 10.1016/j.ijcchd.2026.100707. eCollection 2026 Sep.ABSTRACTBACKGROUND: Mechanical valve thrombosis is a serious complication in adults with congenital heart disease (ACHD). Although low-dose thrombolytic therapy has emerged as a potential

N Naoto Shingu

Hospital Admission Despite Low-Risk History, Electrocardiogram, Age, Risk factors, and Troponin (HEART) Scores and 30-Day Outcomes in Emergency Department Chest Pain

J Am Coll Emerg Physicians Open. 2026 Sep 4;7(5):100502. doi: 10.1016/j.acepjo.2026.100502. eCollection 2026 Oct.ABSTRACTOBJECTIVE: To evaluate whether hospital admission of emergency department (ED) patients despite low-risk History, Electrocardiogram, Age, Risk factors, and Troponin (HEART) scores

H Hao Wang

From HIV to SARS-CoV-2 associated neurological disorder ("HAND" to "SAND"): Viral infection as a "time-bomb" for the aging brain

Neurosci Appl. 2026 Aug 29;5:107024. doi: 10.1016/j.nsa.2026.107024. eCollection 2026.ABSTRACTIn 2020, a novel Coronavirus, Severe Acute Respiratory Syndrome-Covid-2 (SARS-CoV-2), spread globally to provoke a pandemic that infected over 750 million people. The associated disorder, Coronavirus-19 (CO

M Mark J Millan

Rest Unassured: A Systematic Review on the Impacts of Daytime Napping in the Mediterranean on Health Outcomes, Quality of Life, and Lifespan

Am J Lifestyle Med. 2026 Sep 11:15598276261481759. doi: 10.1177/15598276261481759. Online ahead of print.ABSTRACTDaytime napping is a culturally embedded practice in Mediterranean populations, yet its health impacts remain unclear. When assessed in an international context, the impact of napping sho

L Liam Ellis

Features of Asymptomatic Pheochromocytoma/Paraganglioma Based on Clinical-Laboratory Examination and Computed Tomography

Probl Endokrinol (Mosk). 2026 Sep 8;72(4):18-27. doi: 10.14341/probl13639.ABSTRACTBACKGROUND: Although pheochromocytomas and paragangliomas (PPGLs) classically present with distinct clinical signs, there is a category of patients with asymptomatic disease course. Despite the absence of clinical mani

D D V Rebrova

Lysophosphatidylcholine-induced macrophage polarization imbalance and functional dysregulation in immune thrombocytopenia

Chin Med J (Engl). 2026 Sep 14. doi: 10.1097/CM9.0000000000004172. Online ahead of print.ABSTRACTBACKGROUND: The pathogenesis of immune thrombocytopenia (ITP) involves platelet destruction driven by immune dysregulation, notably macrophage dysfunction. Lysophosphatidylcholine (LPC), a class of bioac

N Nan Jiang

Impact of Chronic Kidney Disease Severity on Outcomes in STEMI-Associated Cardiogenic Shock Requiring Mechanical Circulatory Support

Catheter Cardiovasc Interv. 2026 Sep 13. doi: 10.1002/ccd.70881. Online ahead of print.ABSTRACTBACKGROUND: Patients with chronic kidney disease (CKD) presenting with ST-elevation myocardial infarction (STEMI) complicated by cardiogenic shock have significantly worse outcomes when compared with those

A Adishwar Rao

Feasibility and Procedural Considerations of Balloon-Expandable TAVR in Patients With Prior Endovascular Aortic Stent Grafts

Catheter Cardiovasc Interv. 2026 Sep 13. doi: 10.1002/ccd.70867. Online ahead of print.ABSTRACTOBJECTIVES: To evaluate the feasibility and short-term outcomes of transcatheter aortic valve replacement (TAVR) using balloon-expandable Sapien valves in patients with prior endovascular aortic stent graf

I Iad Alhallak

Comparison of Carotid Intima-Media Thickness and Serum Endocan Levels in Surgical and Natural Menopause With Premenopausal Women

J Obstet Gynaecol Res. 2026 Sep;52(9):e70497. doi: 10.1111/jog.70497.ABSTRACTAIM: Menopause is associated with increased cardiovascular risk due to estrogen depletion. This study aimed to compare carotid intima-media thickness (CIMT) and serum endocan levels in women with natural menopause, surgical

A Ayse Derya Topal

A family report of Fabry disease with bilateral foot pain as the initial symptom

Zhonghua Nei Ke Za Zhi. 2026 Sep 1;65(9):1022-1024. doi: 10.3760/cma.j.cn112138-20251230-00803.ABSTRACT患者女，16岁，因反复双足疼痛7年入惠州市第一人民医院。患者9岁起表现为活动时双足趾对称性刺痛或蚁咬感；患者父亲10岁开始出现同样的症状，37岁确诊尿毒症，目前长期接受血液透析治疗。α-Gal A活性检测显示患者酶活性正常，父亲酶活性明显降低，GLA基因检测显示患者存在c.718_719 del（p.Lys240Glufs*9）杂合缺失，父亲为半合缺失。患者目前正在进行酶替代治疗，疼痛症状改

L L E Kong

A case of paraganglioma-related catecholamine-induced cardiomyopathy manifesting as dilated cardiomyopathy and literature review

Zhonghua Nei Ke Za Zhi. 2026 Sep 1;65(9):1010-1015. doi: 10.3760/cma.j.cn112138-20260206-00080.ABSTRACTParaganglioma (PGL) are rare, catecholamine-secreting neuroendocrine neoplasms arising from the adrenal medulla or the extra-adrenal paraganglionic system. Excessive secretion of catecholamines by

H H Y Li