The Genetic and Epigenetic Mechanisms of mtDNA in Regulation of Inflammation and Metabolism

FASEB J. 2026 Oct 15;40(19):e72346. doi: 10.1096/fj.202600927R.ABSTRACTMitochondria serve as the primary cellular powerhouses, generating ATP through oxidative phosphorylation (OXPHOS) to sustain essential cellular processes. Beyond energy production, mitochondria function as critical regulators of

Y Yulin Zhang

Rapid and Efficient Affinity Isolation of Engineered Extracellular Vesicles Encapsulating Functional Proteins via Internal Twin-Strep Tetraspanin Tagging

Small. 2026 Oct 5:e75973. doi: 10.1002/smll.75973. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are mediators of intercellular communication and promising protein-delivery vehicles, but isolation of sufficiently pure, intact, engineered EVs remains challenging due to abundant cellular

M Minh-Tu Pham

Functional Hypothalamic Amenorrhea Phenotype and Cardiovascular Disease Risk

J Clin Endocrinol Metab. 2026 Oct 5:dgag405. doi: 10.1210/clinem/dgag405. Online ahead of print.ABSTRACTCONTEXT: Menstrual irregularities have been associated with cardiovascular disease (CVD) risk, but underlying etiologies may confer distinct risk profiles. Functional hypothalamic amenorrhea (FHA)

C Chrisandra L Shufelt

The silent dialogue between cells: regulatory roles of non-coding RNAs in cardiovascular disease

Front Cell Dev Biol. 2026 Sep 21;14:1921212. doi: 10.3389/fcell.2026.1921212. eCollection 2026.ABSTRACTNon-coding RNAs (ncRNAs) are involved in the occurrence, progression, and repair of cardiovascular disease By post-transcriptional regulation, epigenetic modification, cell-fate determination, and

Z Zhongwen Zhang

Cardiovascular-Kidney-Metabolic Syndrome and Health Risk Behaviors in U.S. Adults

AJPM Focus. 2026 Jul 15;5(6):100529. doi: 10.1016/j.focus.2026.100529. eCollection 2026 Dec.ABSTRACTINTRODUCTION: Cigarette smoking, vaping, and excessive alcohol consumption are established risk factors for many diseases, but few studies have examined these health-risk behaviors in relation to card

M Mehek Sharma

A novel adenoma-carcinoma sequence- and disulfidptosis-associated gene signature for prognostic prediction and mechanistic insights in colorectal cancer

No abstractGenes Dis. 2026 Jun 3;14(2):102269. doi: 10.1016/j.gendis.2026.102269. eCollection 2027 Feb.NO ABSTRACTPMID:42831183 | PMC:PMC13634562 | DOI:10.1016/j.gendis.2026.102269

Z Zhen Wang

Altered Acylcarnitine Metabolism in cardiac diseases: From molecular mechanisms to translational potential

Int J Cardiol Heart Vasc. 2026 Sep 25;67:102010. doi: 10.1016/j.ijcha.2026.102010. eCollection 2026 Dec.ABSTRACTCardiovascular diseases (CVDs) are a leading global cause of mortality and disease burden, closely associated with the remodeling of myocardial energy metabolism. Acylcarnitines (Acs) are

J Jiazhen Wu

Effects of Lanthanum Carbonate on Whole-Body Phosphorus and Calcium Balance in Adults With Chronic Kidney Disease and Normophosphatemia

Kidney Med. 2026 Aug 12;8(10):101496. doi: 10.1016/j.xkme.2026.101496. eCollection 2026 Oct.ABSTRACTRATIONALE & OBJECTIVE: Greater serum phosphorus is associated with cardiovascular disease in those with chronic kidney disease (CKD). However, the utility of phosphorus lowering in nondialysis-requiri

A Anna Jovanovich

Investigating the effects of missense mutations on the dual Ras/Rap activation mechanism of SYNGAP1 using molecular modelling

J Struct Biol X. 2026 Sep 10;14:100162. doi: 10.1016/j.yjsbx.2026.100162. eCollection 2026 Dec.ABSTRACTSynGAP (Synaptic GTPase-Activating Protein) is enriched in the postsynaptic density, where it accelerates GTP hydrolysis by Ras- and Rap-GTPases. In forebrain, SynGAP is essential for synaptic plas

A Aliaa E Ali

The Role of Exosomes in Pulmonary Hypertension: Mechanisms and Therapeutic Potential

Int J Nanomedicine. 2026 Sep 30;21:644296. doi: 10.2147/IJN.S644296. eCollection 2026.ABSTRACTPulmonary hypertension (PH) is a progressive vasculopathy characterized by pulmonary vascular remodeling, right ventricular maladaptation, and premature death. Exosomes, an endosome-derived subset of small

M Mengnan Yuan

Sex differences in management and outcomes after out-of-hospital cardiac arrest with angiographically confirmed obstructive coronary artery disease

Resusc Plus. 2026 Sep 14;32:101490. doi: 10.1016/j.resplu.2026.101490. eCollection 2026 Nov.ABSTRACTBACKGROUND: Previous studies have reported sex-based disparities in care, often disadvantaging women. Large registry analyses are limited by incomplete characterization of out-of-hospital cardiac arre

K Klaudia Svitekova

Differential contribution of elastin and fibrillin-1 to the cardiovascular phenotype of a double heterozygous Marfan and Williams-Beuren syndrome mouse model

No abstractGenes Dis. 2026 Jun 1;14(2):102268. doi: 10.1016/j.gendis.2026.102268. eCollection 2027 Feb.NO ABSTRACTPMID:42831095 | PMC:PMC13634561 | DOI:10.1016/j.gendis.2026.102268

I Isaac Rodríguez-Rovira

Unmet Needs and New Opportunities in Chronic Obstructive Pulmonary Disease in Italy: A Narrative Review with Insights from the GULP Study

Int J Chron Obstruct Pulmon Dis. 2026 Sep 30;21:628160. doi: 10.2147/COPD.S628160. eCollection 2026.ABSTRACTThe "DescribinG bUrden of COPD and occurrence of mortaLity in a cohort of Italian Patients" (GULP) study was conducted to investigate the potential of biological treatments for patients with s

D Dejan Radovanovic

Psychosocial, Mental, and Suboptimal Health Measures Are Not Affected by Provision of Abdominal Aortic Calcification Imaging Results: A 12-Week RCT

AJPM Focus. 2026 May 9;5(6):100507. doi: 10.1016/j.focus.2026.100507. eCollection 2026 Dec.ABSTRACTINTRODUCTION: The provision of abdominal aortic calcification imaging results can elicit cardiovascular disease risk-reducing behaviors. However, its impact on psychosocial, mental, and suboptimal heal

S Simone Radavelli-Bagatini

Response to the Letter to the Editor Entitled "From Molecular Signal to Clinical Action in Cardiovascular-Kidney-Metabolic Disease 2"

No abstractKidney Int Rep. 2026 Aug 11;11(11):107016. doi: 10.1016/j.ekir.2026.107016. eCollection 2026 Nov.NO ABSTRACTPMID:42831070 | PMC:PMC13634270 | DOI:10.1016/j.ekir.2026.107016

W William R Marshall

TET 2-mutant clonal hematopoiesis is associated with peripheral bypass graft occlusion: A multicenter retrospective cohort pilot study

JVS Vasc Sci. 2026 Aug 23;7:100442. doi: 10.1016/j.jvssci.2026.100442. eCollection 2026.ABSTRACTOBJECTIVE: Clonal hematopoiesis of indeterminate potential (CHIP), defined by somatic mutations in hematopoietic cells, is associated with cardiovascular disease through proinflammatory mechanisms. We inv

E Elena Streck

Mycobacterium smegmatis Infection in a Cardiovascular Implantable Electronic Device in an Immunocompetent Patient

Cureus. 2026 Sep 4;18(9):e115768. doi: 10.7759/cureus.115768. eCollection 2026 Sep.ABSTRACTCardiovascular implantable electronic devices (CIEDs) are increasingly utilized for arrhythmia management, but device-related infections remain a significant complication. Rapidly growing non-tuberculous mycob

M Mustafa Nuaimi

Smart Dressings for Pre-Ulcer Risk Surveillance and Closed-Loop Chronic Wound Management: Advances, Discrepancies, and Translational Horizons

Int J Nanomedicine. 2026 Sep 30;21:640692. doi: 10.2147/IJN.S640692. eCollection 2026.ABSTRACTChronic ulcers, including diabetic foot ulcers, pressure ulcers, and venous leg ulcers, remain a major clinical challenge due to their progressive tissue deterioration and high recurrence rates. Current pre

Y Yesen Shou

Cardiac Function in Pediatric Nephrotic Syndrome: Tissue Doppler Echocardiography

Res Heart Yield Transl Med. 2025;20(2):116-125. doi: 10.18502/jthc.v20i2.19707.ABSTRACTHIGHLIGHTS: Children with idiopathic nephrotic syndrome show early heart dysfunction before symptoms appear.Tissue Doppler Echocardiography revealed reduced myocardial velocities, elevated MPI, and altered relaxat

N Noor Mohammad Noori

Immune-Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy

MedComm (2020). 2026 Oct 4;7(10):e71040. doi: 10.1002/mco2.71040. eCollection 2026 Oct.ABSTRACTImmune-cell dynamics within the tumor microenvironment (TME) determine whether immune cells can reach, recognize, and sustain antitumor function against malignant cells under suppressive pressure. These dy

P Pin Guo

Cognitive Behavioral Therapy and Pain Chronification: Neuroimmune Rationale, Evidence Boundaries, and Trial Design Priorities: A Structured Narrative Review

J Pain Res. 2026 Sep 30;19:635577. doi: 10.2147/JPR.S635577. eCollection 2026.ABSTRACTBACKGROUND: Pain chronification is a dynamic transition in which persistent pain may be shaped by interacting nociceptive, peripheral, spinal, supraspinal, neuroimmune, endocrine and cognitive-affective processes.

Y Yi Xi

Unpacking the Obesity Paradox in Lung Cancer: A Nationwide Analysis of In-Hospital Mortality From the US National Inpatient Sample (2020-2022)

Cureus. 2026 Sep 4;18(9):e115771. doi: 10.7759/cureus.115771. eCollection 2026 Sep.ABSTRACTBackground Lung cancer remains the leading cause of cancer-related mortality worldwide. Although obesity is an established risk factor for multiple malignancies, numerous studies have reported an "obesity para

R Rohith Kode

Increased Local Expression of Interleukin-1β in Patients with Acute Myocardial Infarction with Local Layered Plaque

J Inflamm Res. 2026 Sep 30;19:597290. doi: 10.2147/JIR.S597290. eCollection 2026.ABSTRACTBACKGROUND: Patients with acute myocardial infarction are found to have layered plaque in the culprit lesion site during optical coherence tomography, indicating that these patients have experienced recurrent th

M Minghao Liu

Nanoparticle-Mediated Lutein Delivery for Diabetic Retinopathy: From Blood-Retinal Barrier Crossing to Neurovascular Unit Protection

Int J Nanomedicine. 2026 Sep 29;21:633993. doi: 10.2147/IJN.S633993. eCollection 2026.ABSTRACTDiabetic retinopathy (DR) is increasingly understood as an integrated neurovascular unit (NVU) pathology driven by chronic hyperglycemia, rather than solely a microvascular complication. Anti-vascular endot

Y Yanan Wang