Nat Med. 2026 Jan 2. doi: 10.1038/s41591-025-04124-5. Online ahead of print.ABSTRACTGlucagon-like peptide-1 medicines are being prescribed to growing numbers of patients worldwide, for type 2 diabetes, obesity and associated comorbidities, including cardiovascular disease, peripheral artery disease
Nat Cancer. 2026 Jan 2. doi: 10.1038/s43018-025-01067-1. Online ahead of print.ABSTRACTDespite the promise of immune checkpoint blockade (ICB) in head and neck squamous cell carcinoma (HNSCC), mediators of response are poorly understood. To address this, here we analyzed oropharyngeal HNSCCs treated
J Obstet Gynaecol Res. 2026 Jan;52(1):e70181. doi: 10.1111/jog.70181.ABSTRACTAndersen-Tawil syndrome (ATS), also known as congenital long QT syndrome type 7 (LQT7), is a rare inherited channelopathy caused by KCNJ2 mutations and characterized by ventricular arrhythmias, periodic paralysis, and dysmo
J Cardiovasc Comput Tomogr. 2026 Jan 2:S1934-5925(25)00590-8. doi: 10.1016/j.jcct.2025.12.003. Online ahead of print.ABSTRACTBACKGROUND: The Agatston score is commonly used for coronary artery calcium (CAC) quantification which integrates calcium volume and density into a single measure. Recent stud
Gut. 2026 Jan 2:gutjnl-2025-337298. doi: 10.1136/gutjnl-2025-337298. Online ahead of print.ABSTRACTIBD is rising worldwide and is now a global disease. With the expanding armamentarium of medical therapies, including biologics and small molecules, there is a decline in hospitalisation rates and IBD-
Lancet Haematol. 2026 Jan;13(1):e30-e40. doi: 10.1016/S2352-3026(25)00298-4.ABSTRACTBACKGROUND: Iberdomide is an oral cereblon E3 ligase modulator with higher affinity to cereblon than immunomodulatory drugs, leading to improved direct anti-myeloma activity and enhanced immunostimulatory effects. We
In Vivo. 2026 Jan-Feb;40(1):600-627. doi: 10.21873/invivo.14224.ABSTRACTSGLT2 inhibitors (SGLT2is) and GLP-1 receptor agonists (GLP-1RAs) are two novel anti-diabetic therapeutic classes with an important impact on cardiovascular outcomes. Ongoing clinical trials are further investigating their poten
In Vivo. 2026 Jan-Feb;40(1):551-560. doi: 10.21873/invivo.14220.ABSTRACTBACKGROUND/AIM: Pulmonary arterial hypertension (PAH) is a significant and challenging complication for patients with systemic lupus erythematosus (SLE). It is thought to arise from immune dysregulation and vascular remodeling,
In Vivo. 2026 Jan-Feb;40(1):465-473. doi: 10.21873/invivo.14210.ABSTRACTBACKGROUND/AIM: Bevacizumab (Bev) often induces hypertension and proteinuria. Optimal antihypertensive management in this setting remains unclear, and studies comparing angiotensin II receptor blockers (ARBs) and calcium channel
In Vivo. 2026 Jan-Feb;40(1):64-75. doi: 10.21873/invivo.14173.ABSTRACTBACKGROUND/AIM: Hereditary hemorrhagic telangiectasia (HHT) is a rare disease with an incidence of 1:5,000. HHT is inherited in an autosomal dominant manner and is associated with vascular malformations. It particularly affects th
In Vivo. 2026 Jan-Feb;40(1):663-676. doi: 10.21873/invivo.14228.ABSTRACTBACKGROUND/AIM: Metabolic comorbidities, such as diabetes mellitus (DM) and hypertension (HTN), can influence the severity and progression of oropharyngeal infections. This study investigated the impact of these conditions on in
In Vivo. 2026 Jan-Feb;40(1):495-501. doi: 10.21873/invivo.14213.ABSTRACTBACKGROUND/AIM: Hyperlipidemia is a major risk factor for cardiovascular diseases. Pharmacological treatment and lifestyle modifications are the main therapeutic approaches; however, some patients respond poorly or have limited
Prev Med. 2025 Dec 31:108492. doi: 10.1016/j.ypmed.2025.108492. Online ahead of print.ABSTRACTOBJECTIVE: This systematic review examined the association between adolescent overweight and all-cause and cause-specific mortality in adulthood.METHODS: We searched for studies published between 2014 and 2
J Nutr. 2025 Dec 31:101306. doi: 10.1016/j.tjnut.2025.101306. Online ahead of print.ABSTRACTBACKGROUND: Socioeconomic status (SES) affects lifestyle behaviours and may influence blood pressure (BP). Food availability, accessibility, and affordability determine individual and population food consumpt
Diabetes Res Clin Pract. 2025 Dec 31:113079. doi: 10.1016/j.diabres.2025.113079. Online ahead of print.ABSTRACTAIMS: Early detection of impaired glucose tolerance (IGT) is critical for preventing overt diabetes and cardiovascular disease. Few studies have evaluated the predictors of the transition f
Complement Ther Med. 2025 Dec 31:103317. doi: 10.1016/j.ctim.2025.103317. Online ahead of print.ABSTRACTBACKGROUND: Diaphragmatic breathing (DB) is widely used clinically, but a comprehensive synthesis of randomized controlled trial (RCT) evidence on its health effects is lacking. This systematic re
Neurotoxicology. 2025 Dec 31:103378. doi: 10.1016/j.neuro.2025.103378. Online ahead of print.ABSTRACTAmbient air pollution exposures increase risk for Alzheimer's disease (AD) and related dementias, possibly due to structural changes in the medial temporal lobe (MTL). However, previous MRI studies e
Transplant Cell Ther. 2025 Dec 31:S2666-6367(25)02655-7. doi: 10.1016/j.jtct.2025.12.994. Online ahead of print.ABSTRACTBACKGROUND AND OBJECTIVES: Atypical manifestations of chronic graft-versus-host disease (cGVHD) can affect both the central and peripheral nervous system, presenting with diverse c
Can J Cardiol. 2025 Dec 31:S0828-282X(25)01614-9. doi: 10.1016/j.cjca.2025.12.046. Online ahead of print.ABSTRACTBACKGROUND: Multivalvular heart disease (MVHD) is frequently encountered in patients undergoing transcatheter aortic valve replacement (TAVR). However, the long-term prognostic impact of
Surv Ophthalmol. 2025 Dec 31:S0039-6257(25)00236-X. doi: 10.1016/j.survophthal.2025.12.007. Online ahead of print.ABSTRACTInitially designed for the treatment of type-2 diabetes, glucagon-like peptide-1 receptor agonists (GLP-1RA) are multifaceted agents with promising neuroprotective and anti-infla
Free Radic Biol Med. 2025 Dec 31:S0891-5849(25)01449-2. doi: 10.1016/j.freeradbiomed.2025.12.040. Online ahead of print.ABSTRACTWang and colleagues (Wang, et al, Free Rad Biol Med, 242 (2026) 167-187) have found in in silico and in vitro experiments, that multifaceted molecule genistein inhibits man
Am Heart J. 2025 Dec 31:107337. doi: 10.1016/j.ahj.2025.107337. Online ahead of print.ABSTRACTBACKGROUND: Early structural heart disease (SHD) detection is crucial for improving prognostic outcomes, but widely accessible screening methods are lacking. The advent of artificial intelligence-enabled el
Am J Cardiol. 2025 Dec 31:S0002-9149(25)00723-4. doi: 10.1016/j.amjcard.2025.11.019. Online ahead of print.ABSTRACTSevere coronary artery calcification (CAC) complicates high-risk percutaneous coronary intervention (HRPCI), particularly in patients with impaired left ventricular function. Atherectom
Ann Thorac Surg. 2025 Dec 31:S0003-4975(25)01274-3. doi: 10.1016/j.athoracsur.2025.12.009. Online ahead of print.ABSTRACTBACKGROUND: Hypertrophic obstructive cardiomyopathy (HOCM) is a structurally heterogeneous disease with variable clinical outcomes. While septal myectomy provides symptomatic bene
