Hormones, heat, and health: a comprehensive review of sex-based differences in brown and beige fat biology

Biol Sex Differ. 2025 Dec 31. doi: 10.1186/s13293-025-00787-4. Online ahead of print.ABSTRACTThis review takes a close look at the biology of brown and beige fat, not just as thermogenic tissues, but as active metabolic organs influenced by sex, hormones, age, and even environment. Brown adipose tis

C Chikkamagaluru Gopalakrishna Shashank

Association between combined atherogenic and frailty index and cardiovascular events: evidence from the CHARLS cohort

Cardiovasc Diabetol. 2025 Dec 31. doi: 10.1186/s12933-025-03051-6. Online ahead of print.ABSTRACTOBJECTIVE: The atherogenic index of plasma (AIP) is a marker of atherosclerosis, while frailty reflects cumulative physiological decline. However, the combined impact of AIP-frailty index (AIP-FI) has no

G Guijun Huo

Molecular insights in HIV-associated cardiac dysfunction

Commun Med (Lond). 2025 Dec 31. doi: 10.1038/s43856-025-01349-w. Online ahead of print.ABSTRACTBACKGROUND: Antiretroviral therapy (ART) in human immunodeficiency virus (HIV) markedly improved life expectancy in persons living with HIV (PLWH), but cardiac disease has emerged as the leading cause of d

M María Valero-Muñoz

cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

Nat Methods. 2025 Dec 31. doi: 10.1038/s41592-025-02919-5. Online ahead of print.ABSTRACTUnderstanding how rare genetic variants influence complex traits remains a major challenge, particularly when these variants lie in noncoding regions of the genome. The effects of variants within candidate cis-r

E Eric Van Buren

Drug-related hepatotoxicity risk in elderly patients with atrial fibrillation: insights from the nationwide Italian START registry

Sci Rep. 2025 Dec 31;15(1):45782. doi: 10.1038/s41598-025-28502-8.ABSTRACTAtrial fibrillation (AF) patients frequently require polypharmacy, increasing the risk of drug-drug interactions and hepatotoxicity. We analyzed the use of drugs potentially associated with liver injury in anticoagulated AF pa

G Gianluca Gazzaniga

High-throughput combinatorial screening of antiplatelet drugs for personalized medicine

Microsyst Nanoeng. 2026 Jan 1;12(1):7. doi: 10.1038/s41378-025-01126-8.ABSTRACTCardiovascular disease (CVD) remains the leading cause of death worldwide. Platelet activation plays a critical role in arterial thrombotic events such as myocardial infarction. Although antiplatelet drugs are standard th

C Chenguang Wang

Endoglin as a BMP9 co-receptor in vascular endothelial cells: prodomain displacement and TGFBRII recruitment

Nat Commun. 2025 Dec 31. doi: 10.1038/s41467-025-67531-9. Online ahead of print.ABSTRACTEndoglin (ENG) is a single-pass transmembrane protein highly expressed in vascular endothelial cells (ECs), where it plays fundamental roles in EC functions. ENG is implicated in several cardiovascular disorders

J Jingxu Guo

Five-Decade Mortality Trends in Ischemic Stroke in the United States: A CDC WONDER Analysis

Brain Behav. 2026 Jan;16(1):e71177. doi: 10.1002/brb3.71177.ABSTRACTINTRODUCTION: Ischemic stroke, comprising nearly 85% of all strokes, remains a leading cause of death and disability worldwide. Annually, about 795,000 individuals in the United States (US) experience a new or recurrent stroke. Desp

R Rameez Qasim

Cardiovascular Health Status, Migraine Risk, and Mortality Outcomes in Migraine Individuals: Insights From NHANES

Brain Behav. 2026 Jan;16(1):e71162. doi: 10.1002/brb3.71162.ABSTRACTOBJECTIVES: The study analyzes the link between cardiovascular health, measured through the Life's Simple 7 (LS7) score, and the potential risk of migraines. Moreover, the research delves into the possibility that better cardiovascu

H Hongwei Liu

Genetic Risk Factors for Poor Cognitive Outcome Following Brain Insult-A Systematic Review

Brain Behav. 2026 Jan;16(1):e71173. doi: 10.1002/brb3.71173.ABSTRACTINTRODUCTION: Cognitive outcomes following brain insult are shaped by a range of factors, including genetic predispositions. Emerging evidence indicates that specific genetic variants may affect the susceptibility to cognitive impai

T Tora Dunås

The impact of intermittent fasting on lipid profile - an umbrella review

Nutr Metab Cardiovasc Dis. 2025 Nov 21:104472. doi: 10.1016/j.numecd.2025.104472. Online ahead of print.ABSTRACTAIMS: Cardiovascular diseases are the leading cause of mortality worldwide with lipid disorders as one of the main modifiable risk factors. Lifestyle modification, including dietary approa

J Joanna Popiolek-Kalisz

GSK3βhigh/NFATc1high subtype targeting overcomes therapy resistance in pancreatic cancer through transcriptional induction of homologous recombination repair

CONCLUSION: We have identified a highly aggressive GSK3β^(high)/NFATc1^(high) subtype that predicts early recurrence, poor survival and cisplatin resistance in PDAC. This subtype reveals new treatment vulnerabilities suggesting that patients with PDAC may benefit from stratification-based tailored t

M Muhammad Umair Latif

Negative exercise stress echocardiography and long-term outcomes: insights from a retrospective cohort study

Heart. 2025 Dec 31:heartjnl-2025-326938. doi: 10.1136/heartjnl-2025-326938. Online ahead of print.ABSTRACTBACKGROUND: Exercise stress echocardiography (ESE) is widely used to detect inducible myocardial ischaemia. However, a substantial proportion of ESEs remains inconclusive or shows abnormal non-i

E Elton Carreiro Da Cunha

Elevated lipoprotein(a) in patients with premature atherosclerotic cardiovascular disease: Insights from a large US real-world cohort

J Clin Lipidol. 2025 Nov 28:S1933-2874(25)00522-7. doi: 10.1016/j.jacl.2025.11.015. Online ahead of print.ABSTRACTBACKGROUND: Patients experiencing premature cardiovascular events (males: <55 years; females: <65 years) represent a high-risk subgroup within the atherosclerotic cardiovascular disease

X Xingdi Hu

Corrigendum to "Comparative study of rapid influenza antigen tests versus PCR in an influenza-like illness population: A real-world multicenter study in China" [Infection, Genetics and Evolution, volume 133, article 105794]

No abstractInfect Genet Evol. 2025 Dec 30:105873. doi: 10.1016/j.meegid.2025.105873. Online ahead of print.NO ABSTRACTPMID:41475908 | DOI:10.1016/j.meegid.2025.105873

T Tongyan Zhang

Development of machine learning models to predict risk of hospitalisation and 90-day readmission among patients with cardiovascular risk factors using community health survey data

BMJ Health Care Inform. 2025 Dec 31;32(1):e101742. doi: 10.1136/bmjhci-2025-101742.ABSTRACTOBJECTIVES: This study aimed to develop and validate machine learning (ML) models to predict all-cause hospital admissions and 90-day readmissions using structured, patient-reported survey data.METHODS: A cros

A Arinze Nkemdirim Okere

Levofloxacin-induced dyskinesia in an elderly patient with granulomatosis with polyangiitis

BMJ Case Rep. 2025 Dec 31;18(12):e267570. doi: 10.1136/bcr-2025-267570.ABSTRACTThis case report presents an early 60s male patient who developed generalised tremor and dyskinesia within 24 hours of initiating levofloxacin treatment for community-acquired pneumonia and was diagnosed with granulomatou

İ İrada İbramkhalilova

Lacunar stroke with incidental congenital absence of the internal carotid artery: importance of recognising a rare anatomical variant

BMJ Case Rep. 2025 Dec 31;18(12):e268527. doi: 10.1136/bcr-2025-268527.ABSTRACTWe report a case of a woman in her 50s who presented with a left lacunar infarct and was incidentally found to have congenital absence of the ipsilateral internal carotid artery (ICA). This rare vascular anomaly was confi

W Woei Ling Lai

Association between trisomy 21 and 'puff of smoke' with an unusual presentation of transient ischaemic attack

BMJ Case Rep. 2025 Dec 31;18(12):e267602. doi: 10.1136/bcr-2025-267602.ABSTRACTHere we present the case of a paediatric patient with Down syndrome associated with Moyamoya disease. The patient came with symptoms of transient ischaemic attacks. Scans revealed occlusion of the internal carotid artery,

A Aiswarya Raju

Extensive coronary-cameral fistulas and incidental left ventricular papillary fibroelastoma

BMJ Case Rep. 2025 Dec 31;18(12):e269899. doi: 10.1136/bcr-2025-269899.ABSTRACTWe report the rare coexistence of extensive coronary-cameral fistulas (CCFs) with aneurysmal dilatation of coronary arteries and an incidental left ventricular papillary fibroelastoma (PFE) in a female in her early 70s wh

M Muhammad Usman Almani

Recurrent deep vein thrombosis and pulmonary embolism in a patient with May-Thurner syndrome presenting as low back pain and radiculopathy

BMJ Case Rep. 2025 Dec 31;18(12):e270176. doi: 10.1136/bcr-2025-270176.ABSTRACTLow back pain is among the most common clinical presentations worldwide, with most cases attributed to musculoskeletal or degenerative causes. Vascular pathology, however, is often overlooked in the differential. We descr

A Ahmed Khawer

Tachyarrhythmia-induced cardiomyopathy in a neonate

BMJ Case Rep. 2025 Dec 31;18(12):e269500. doi: 10.1136/bcr-2025-269500.ABSTRACTTachycardia-induced cardiomyopathy (TIC) can result in both systolic and/or diastolic ventricular dysfunction as a result of the prolonged fast heart rate which is reversible on controlling the fast heart rate or arrhythm

N Neha Dalal

Hemosuccus pancreaticus in paediatric patients: unmasking the concealed haemorrhage of the pancreas by contemplating beyond endoscopy

BMJ Case Rep. 2025 Dec 31;18(12):e269762. doi: 10.1136/bcr-2025-269762.ABSTRACTHemosuccus pancreaticus represents an exceedingly rare aetiology of gastrointestinal haemorrhage in the paediatric population, characterised by bleeding emanating from the ampulla of Vater via the pancreatic duct. Its inf

H Harsh Agarwal

Concordance between presenting features and relapse in granulomatosis with polyangiitis: implications for risk assessment and counselling

RMD Open. 2025 Dec 31;11(4):e006434. doi: 10.1136/rmdopen-2025-006434.ABSTRACTOBJECTIVE: To investigate the concordance between organ involvement at diagnosis and relapse in granulomatosis with polyangiitis and factors associated with new disease features at relapse.METHODS: Data from a national dat

M Michele Iudici