Elevated cardiovascular risk in people living with HIV: the association with coronary artery calcification and endothelial dysfunction

AIDS. 2025 Nov 21. doi: 10.1097/QAD.0000000000004414. Online ahead of print.ABSTRACTOBJECTIVE: This study aimed to assess the burden, severity, and pattern of Coronary artery disease (CAD) in people with HIV (PWH), as well as its relationship with metabolic syndrome, inflammation, and endothelial dy

A Anas Ismail

Analysis of risk factors for left atrial appendage thrombus formation in patients with atrial fibrillation

Gen Thorac Cardiovasc Surg. 2025 Nov 24. doi: 10.1007/s11748-025-02228-w. Online ahead of print.ABSTRACTOBJECTIVE: To identify predictors of left atrial appendage thrombus formation.METHODS: We retrospectively analyzed 149 patients with persistent or paroxysmal atrial fibrillation who underwent card

M Masanori Nishimura

In Silico Clinical Trials in Drug Development: A Systematic Review

Ther Innov Regul Sci. 2025 Nov 24. doi: 10.1007/s43441-025-00893-w. Online ahead of print.ABSTRACTIn the context of clinical research, computational models have received increasing attention over the past decades. In this systematic review, we aimed to provide an overview of the role of so-called in

B Bohua Chen

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Ann N Y Acad Sci. 2025 Nov 24. doi: 10.1111/nyas.70144. Online ahead of print.ABSTRACTVarious cellular processes, such as DNA repair and signal transduction, are regulated through ubiquitination and deubiquitination. Dysregulation of ubiquitination cascade enzymes and deubiquitinating enzymes leads

N None Celemuge

Real-World Adherence and Effectiveness of Inclisiran in Lowering LDL-C: Results from 1 Year of Follow-Up

Cardiol Ther. 2025 Nov 24. doi: 10.1007/s40119-025-00438-0. Online ahead of print.ABSTRACTINTRODUCTION: Atherosclerotic cardiovascular disease (ASCVD) is a global health concern. Reducing low-density lipoprotein cholesterol (LDL-C) is critical in ASCVD prevention and treatment. Inclisiran, a novel R

C Christie M Ballantyne

Comparative review of translational approaches in lipid-based and water-based encapsulation strategies for coenzyme Q10

Drug Deliv Transl Res. 2025 Nov 24. doi: 10.1007/s13346-025-02015-3. Online ahead of print.ABSTRACTThe global coenzyme Q10 (CoQ10) market is expanding, driven by the increasing prevalence of chronic diseases, particularly cardiovascular disorders. Forecasts project a compound annual growth rate of 9

N Norhamiza Mohamad Sukri

Interaction between coronary lesion complexity and coronary microvascular dysfunction in the prognosis of NSTEMI patients

Clin Res Cardiol. 2025 Nov 24. doi: 10.1007/s00392-025-02803-4. Online ahead of print.ABSTRACTBACKGROUND: The prognostic value of the American College of Cardiology/American Heart Association (ACC/AHA) lesion classification in NSTEMI remains insufficiently investigated, especially regarding its inte

P Ping Lin

Impact of subthreshold troponin levels and temporal trends on short term adverse cardiovascular outcomes in patients discharged from the emergency department: a RACE-IT trial substudy

Clin Res Cardiol. 2025 Nov 24. doi: 10.1007/s00392-025-02789-z. Online ahead of print.ABSTRACTBACKGROUND: High-sensitivity cardiac troponin I assays enable early exclusion of myocardial infarction in the emergency department. However, the clinical implications of detectable troponin values below the

M Muhammad Ahmad Qureshi

Atrial Isomerism Adversely Impaired both Early and Late Outcomes in Fontan Circulation

No abstractPediatr Cardiol. 2025 Nov 24. doi: 10.1007/s00246-025-04115-w. Online ahead of print.NO ABSTRACTPMID:41283987 | DOI:10.1007/s00246-025-04115-w

J Jianrui Ma

Risk Factors Associated with Prolonged Mechanical Ventilation and Prolonged Postoperative Hospital Stay after Ozaki Procedure for Pediatric Aortic Valve Diseases

Pediatr Cardiol. 2025 Nov 24. doi: 10.1007/s00246-025-04105-y. Online ahead of print.ABSTRACTThis study evaluated medium and long-term postoperative results to identify perioperative factors that are associated with prolonged mechanical ventilation (PMV) and prolonged postoperative hospital stay (PP

Z Zhangwei Wang

Artificial intelligence-based decision support systems and their role in vascular surgery and clinical practice

J Cardiovasc Surg (Torino). 2025 Nov 24. doi: 10.23736/S0021-9509.25.13491-5. Online ahead of print.ABSTRACTArtificial intelligence-based decision support systems (AI-DSS) are gaining attention in medicine as tools for diagnosis, risk assessment, and treatment planning. By processing large, heteroge

V Venkat Ayyalasomayajula

Preoperative coronary evaluation in valve surgery for infective endocarditis: findings from a multicenter retrospective study

Eur J Clin Microbiol Infect Dis. 2025 Nov 24. doi: 10.1007/s10096-025-05363-7. Online ahead of print.ABSTRACTPURPOSE: International guidelines recommend invasive coronary angiography (ICA) or coronary computed tomography angiography (CCTA) before surgery for infective endocarditis (IE). Given the lo

L Lucas Armange

Factors associated with diagnostic delay and specialty consultation patterns in systemic sclerosis: A cross-sectional study

Rheumatol Int. 2025 Nov 24;45(12):278. doi: 10.1007/s00296-025-06034-8.ABSTRACTEarly diagnosis of Systemic Sclerosis (SSc) is challenging due to nonspecific symptoms and clinical overlap with other autoimmune diseases. To investigate factors associated with diagnostic delays in SSc, focusing on the

Y Yesim Erez

Red cell distribution width positively correlates with 10-year risk of cardiovascular disease among people with type 1 diabetes as assessed by the steno type 1 risk engine

Acta Diabetol. 2025 Nov 24. doi: 10.1007/s00592-025-02615-y. Online ahead of print.ABSTRACTINTRODUCTION: We evaluated the association between Red Cell Distribution Width (RDW) and predicted 10-year cardiovascular disease (CVD) risk, as estimated by the Steno Type 1 Risk Engine (ST1RE), in individual

N Naskret Dariusz

Association between dairy intake and all-cause and cause-specific mortality: a pooled analysis of 0.4 million Japanese adults from 10 population-based cohort studies

Int J Epidemiol. 2025 Oct 14;54(6):dyaf180. doi: 10.1093/ije/dyaf180.ABSTRACTBACKGROUND: The association between dairy intake and mortality remains unclear, particularly in populations with low dairy consumption, such as the Japanese population. Thus, we investigated the associations between dairy i

Y Yukai Lu

The effect of telerehabilitation-based core stabilization exercises on epicardial fat tissue and exercise capacity in hypertensives

Disabil Rehabil. 2025 Nov 24:1-12. doi: 10.1080/09638288.2025.2593190. Online ahead of print.ABSTRACTPURPOSE: This study aimed to investigate the effects of telerehabilitation-based core stabilization exercise training on epicardial adipose tissue (EAT), functional exercise capacity, mobility, and b

E Emine Tunc Suygun

Identification of Protein Markers for Chronic Ischemic Heart Disease Through Integrated Analysis of the Human Plasma Proteome and Genome-Wide Association Data

Proteomes. 2025 Nov 3;13(4):55. doi: 10.3390/proteomes13040055.ABSTRACTBACKGROUND: Chronic ischemic heart disease (CIHD) is characterized by persistent myocardial ischemic due to long-term reduced coronary blood flow. In the past, we mainly relied on surgical intervention or drug therapy to alleviat

C Chunyang Ren

Normobaric Hypoxic Cardiac Rehabilitation: Comparative Effects of Training at 2000 m and 3000 m Simulated Altitude in Post-Myocardial Infarction Patients

J Funct Morphol Kinesiol. 2025 Nov 18;10(4):444. doi: 10.3390/jfmk10040444.ABSTRACTBackground: Coronary artery disease remains the leading cause of morbidity and mortality in developed countries. Despite advances in treatment and standard rehabilitation, conventional programs may be monotonous and i

A Agata Nowak-Lis

Daily Movement Matters: Post-Exercise Hypotension in Peripheral Arterial Disease-A Quasi-Experimental Pilot Study

J Funct Morphol Kinesiol. 2025 Nov 3;10(4):426. doi: 10.3390/jfmk10040426.ABSTRACTBackground: Aerobic and resistance training have acute effects on blood pressure (BP) in peripheral arterial disease (PAD). However, the combined effect of both exercises in a single session is still unknown. The aim o

S Saúl Peñín-Grandes

Hyperferritinemia Is Associated with Higher Adiposity, Metabolic Syndrome, and Hepatic Dysfunction, Mainly Affecting Men: A Study in Southern Brazil

Pathophysiology. 2025 Nov 19;32(4):64. doi: 10.3390/pathophysiology32040064.ABSTRACTObjectives: Serum ferritin (SF) reflects iron homeostasis, in addition to being an acute phase reactant protein. Since its levels are altered in the obesity state, we compared body composition, metabolic profile, liv

K Késia Zanuzo

Pulsed-Field Ablation Is Associated with Lower Endothelial Injury and Procedure Time Compared to Cryoballoon Ablation in Paroxysmal Atrial Fibrillation

Pathophysiology. 2025 Nov 7;32(4):60. doi: 10.3390/pathophysiology32040060.ABSTRACTBACKGROUND: Thromboembolic events, though infrequent, remain a significant complication of atrial fibrillation (AF) ablation, largely related to endothelial damage. Cryoballoon (CB) and radiofrequency ablation can ind

J Josip Katic

Dual Disease Burden: Growing Older with Congenital Heart Disease and Hereditary Metabolic and Connective Tissue Disorders-Data from the PATHFINDER-CHD Registry on Heart Failure

Geriatrics (Basel). 2025 Nov 20;10(6):152. doi: 10.3390/geriatrics10060152.ABSTRACTBackground: Advances in diagnosis and treatment have led to a growing population of adults with congenital heart disease (ACHD). Despite increasing life expectancy, their clinical needs-especially in older age-remain

A Ann-Sophie Kaemmerer-Suleiman

Central Adiposity Assessed with Body Roundness Index and Mortality: The Seguimiento Universidad de Navarra Prospective Cohort

Geriatrics (Basel). 2025 Oct 23;10(6):135. doi: 10.3390/geriatrics10060135.ABSTRACTBackground/Objectives: Obesity is currently a global pandemic and a major risk factor for the development of chronic disease and increased mortality. Common methods used to define obesity, such as body mass index (BMI

L Ligia J Dominguez

Oscillatory Disturbed Flow Enhances Inflammatory and Oxidative Stress Markers in Endothelial Cells

Methods Protoc. 2025 Nov 1;8(6):130. doi: 10.3390/mps8060130.ABSTRACTHemodynamics significantly impact the biology of endothelial cells (ECs) lining the blood vessels. ECs are exposed to various hemodynamic forces, particularly frictional shear stress from flowing blood. While physiological flows ar

M Maram Hasan