From marine predator to pharmacology: Conotoxin diversity, discovery, and therapeutic potential

Zool Res. 2026 Mar 18;47(2):378-403. doi: 10.24272/j.issn.2095-8137.2025.553.ABSTRACTCone snails ( Conus spp.) biosynthesize a highly specialized venom comprising a vast arsenal of neurotoxic peptides, termed conotoxins. These peptides exhibit exceptional structural and functional diversity, charact

K Kai-Lin Mao

Glycolysis-dependent reactive oxygen species mediate desmopressin acetate-induced rescue of platelet dysfunction caused by antiplatelet therapy

Med Gas Res. 2026 Mar 26. doi: 10.4103/mgr.MEDGASRES-D-25-00353. Online ahead of print.ABSTRACTJOURNAL/mgres/04.03/01612956-990000000-00084/figure1/v/2026-03-26T165950Z/r/image-tiff Antiplatelet therapy is extensively used in the prevention and treatment of cardiovascular and cerebrovascular disease

K Kaiwen Wang

Differential serum dynamics of apelin, elabela, and angiotensinogen in CKD and haemodialysis: insights into peptide modulation across the dialysis procedure

Ren Fail. 2026 Dec;48(1):2646404. doi: 10.1080/0886022X.2026.2646404. Epub 2026 Mar 26.ABSTRACTBACKGROUND: Emerging evidence suggests that apelinergic peptides and components of the renin-angiotensin system (RAS) are key regulators of cardiovascular homeostasis and fluid balance, both disrupted in c

N Natalia Maria Serwin

Evaluation and management of metabolic-associated chronic kidney disease

Best Pract Res Clin Endocrinol Metab. 2026 Mar 17:102098. doi: 10.1016/j.beem.2026.102098. Online ahead of print.ABSTRACTMetabolic-associated chronic kidney disease (MACKD), defined as CKD that is caused or exacerbated by metabolic abnormalities, represents a growing global health challenge driven b

S Sunita Bavanandan

Influence of computed tomography reconstruction algorithms on coronary artery calcium scores and reader agreement

J Cardiovasc Comput Tomogr. 2026 Mar 25:S1934-5925(26)00054-7. doi: 10.1016/j.jcct.2026.03.003. Online ahead of print.ABSTRACTBACKGROUND: Coronary artery calcium scoring (CACS) is central to cardiovascular risk stratification. Differences between reconstruction algorithms may introduce inconsistenci

L Lee D Yang

Prevalence and characteristics of patients with coronary heart disease and blood pressure below target: the INTERASPIRE study

Heart. 2026 Mar 26:heartjnl-2025-327413. doi: 10.1136/heartjnl-2025-327413. Online ahead of print.ABSTRACTBACKGROUND: Despite treatment, many hypertensive patients with coronary heart disease (CHD) have blood pressure (BP) that remains above guideline targets. However, less is known about patients i

J John P McCormick

Implementing clinical practice guidelines in cardiology: accelerating the translation of evidence into practice

Heart. 2026 Mar 26:heartjnl-2025-325941. doi: 10.1136/heartjnl-2025-325941. Online ahead of print.ABSTRACTClinical practice guidelines form the foundation of evidence-based care in cardiology, yet gaps persist between the care recommended and that delivered. Passive dissemination of guidelines remai

N Nicola S Creagh

Formononetin downregulates P53/SAT1/ACSL4 pathway-mediated ferroptosis to improve hypoxic-ischemic brain injury in neonatal mice

Nan Fang Yi Ke Da Xue Xue Bao. 2026 Mar 20;46(3):604-614. doi: 10.12122/j.issn.1673-4254.2026.03.14.ABSTRACTOBJECTIVES: To investigate the neuroprotective effects of formononetin (FMN) against hypoxic-ischemic brain damage (HIBD) in neonatal mice and the underlying mechanism.METHODS: Twenty-four neo

T Tao Guo

Eurycomanone inhibits renal ischemia/reperfusion-induced mitochondrial dysfunction and inflammation in mice by binding to STAT3 to inhibit its phosphorylation

Nan Fang Yi Ke Da Xue Xue Bao. 2026 Mar 20;46(3):570-581. doi: 10.12122/j.issn.1673-4254.2026.03.11.ABSTRACTOBJECTIVES: To investigate the mechanism of eurycomanone (EN) for ameliorating ischemia/reperfusion (IR)-induced acute kidney injury (AKI) in mice.METHODS: Twenty-four male C57BL/6J mice were

Z Ze Liu

A nomogram model for predicting MACE risk following primary percutaneous coronary intervention in STEMI patients: an exploratory study based on serum GSDMD

Nan Fang Yi Ke Da Xue Xue Bao. 2026 Mar 20;46(3):550-558. doi: 10.12122/j.issn.1673-4254.2026.03.09.ABSTRACTOBJECTIVES: To investigate the value of serum gasdermin D (GSDMD) level for predicting 30-day major adverse cardiovascular events (MACE) in patients following primary percutaneous coronary int

X Xinyi Hu

An atypical presentation of microscopic polyangiitis without renal involvement in an older patient with falls, bilateral lower limb swelling and neuropathy

BMJ Case Rep. 2026 Mar 26;19(3):e270153. doi: 10.1136/bcr-2025-270153.ABSTRACTMicroscopic polyangiitis (MPA) is a primary systemic small-vessel vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA). The condition is uncommon among the UK population, although it increases with age.

M Molly Sun Wai

Rare coexistence of unroofed coronary sinus, coronary sinus atresia and rheumatic mitral stenosis demonstrated by multimodality imaging

BMJ Case Rep. 2026 Mar 26;19(3):e271489. doi: 10.1136/bcr-2025-271489.ABSTRACTUnroofed coronary sinus (CS) with CS orifice atresia and persistent left superior vena cava (PLSVC) is an exceptionally rare congenital anomaly that may coexist with acquired valvular disease, as illustrated in this case o

D Digvijay Nalawade

Unusual renal vascular adaptations in childhood Takayasu arteritis: a CT angiographic demonstration of extensive collaterals and aberrant arteries

BMJ Case Rep. 2026 Mar 26;19(3):e270427. doi: 10.1136/bcr-2025-270427.ABSTRACTTakayasu arteritis (TA) is a rare large-vessel vasculitis, typically affecting young females. We report a young Indian male with resistant hypertension and bilateral renal artery stenosis, who developed extensive collatera

A Aarosh Dhamija

Prognostic factors in interstitial lung disease-associated pulmonary hypertension: data from the HYPID cohort and the French Pulmonary Hypertension Registry

Eur Respir J. 2026 Mar 26:2502233. doi: 10.1183/13993003.02233-2025. Online ahead of print.ABSTRACTBACKGROUND: Pulmonary hypertension (PH) frequently complicates interstitial lung diseases (ILD), adversely affecting outcome. Identifying prognostic factors of patients with ILD-PH could facilitate ear

R Rémi Diesler

Preventable mortality in Mexico: bridging gaps in chronic disease and ageing care

BMJ Glob Health. 2026 Mar 26;11(3):e019891. doi: 10.1136/bmjgh-2025-019891.ABSTRACTPreventable mortality remains a critical public health challenge in Mexico, with 819 672 deaths recorded in 2024. Of these, 37.21% in the general population were attributed to ischaemic heart disease (IHD) and diabete

H Hector Alejandro Cabrera-Fuentes

Comparison of the efficacy of non-pharmacological interventions for patients with heart failure with preserved ejection fraction: protocol for a systematic review and network meta-analysis of randomised controlled trials

BMJ Open. 2026 Mar 26;16(3):e113093. doi: 10.1136/bmjopen-2025-113093.ABSTRACTINTRODUCTION: Heart failure with preserved ejection fraction (HFpEF) represents a common subtype of heart failure, accounting for approximately 50% of all heart failure cases. It is characterised by a left ventricular ejec

C Cong Li

Identifying ambulatory care sensitive conditions: a systematic review of studies defining sets of diseases with avoidable hospitalisations in European countries

BMJ Open. 2026 Mar 26;16(3):e112777. doi: 10.1136/bmjopen-2025-112777.ABSTRACTBACKGROUND: Ambulatory care sensitive conditions (ACSC) are health conditions that can be adequately managed in the outpatient setting. Timely treatment and interventions may avoid the need for hospitalisation and emergenc

D Daniel Martinho-Dias

Measuring patient adherence in secondary prevention of atherosclerotic cardiovascular disease: a scoping review

BMJ Open. 2026 Mar 26;16(3):e109666. doi: 10.1136/bmjopen-2025-109666.ABSTRACTOBJECTIVE: Atherosclerotic cardiovascular disease (ASCVD) is the main cause of death globally, but is by and large a preventable disease. We wished to identify, categorise and map adherence measurements of preventative tre

M Malene Glud

Microglia promote vascular remodeling in a mouse model of chronic stress

Brain Behav Immun. 2026 Mar 24:106560. doi: 10.1016/j.bbi.2026.106560. Online ahead of print.ABSTRACTMajor Depressive Disorder (MDD) is a debilitating mental illness affecting over 350 million people globally. Chronic stress is a major risk factor for MDD and is associated with increased vascular dy

Z Zachary Hage

Deep Learning-Based Generation of Synthetic Multiphasic MRI In Hepatocellular Carcinoma and Cirrhosis

JHEP Rep. 2026 Mar 4:101813. doi: 10.1016/j.jhepr.2026.101813. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: There is a growing interest in reducing contrast medium use and the lengthy scan duration in liver imaging. This proof-of-concept study aimed to evaluate the feasibility of deep learning

S Sara A Abosabie

CYLD-mediated DNA damage coordinates pathological cardiac hypertrophy via RIPK1-dependent signaling

J Mol Cell Cardiol. 2026 Mar 24:S0022-2828(26)00043-X. doi: 10.1016/j.yjmcc.2026.03.005. Online ahead of print.ABSTRACTCardiac remodeling under pressure overload involves maladaptive changes that lead to heart failure. This study investigated the role of the deubiquitinating enzyme CYLD in this proc

X Xianyun Jiang

From residual risk to real risk: why implementation fails when we misunderstand the problem

No abstractEur J Prev Cardiol. 2026 Mar 27;33(5):640-642. doi: 10.1093/eurjpc/zwaf665.NO ABSTRACTPMID:41887405 | DOI:10.1093/eurjpc/zwaf665

M Michael D Shapiro

Cooling the fire: targeting inflammation in cardiovascular diseases

No abstractEur J Prev Cardiol. 2026 Mar 27;33(5):637-639. doi: 10.1093/eurjpc/zwag111.NO ABSTRACTPMID:41887404 | DOI:10.1093/eurjpc/zwag111

A Alexis F Guédon

Mapping Global Research Trends of Tai Chi for Sleep Health: Scientometric Insights and Network-Based Perspectives

Complement Ther Med. 2026 Mar 24:103365. doi: 10.1016/j.ctim.2026.103365. Online ahead of print.ABSTRACTBACKGROUND: Sleep disorders have become a widespread public health challenge closely linked to cognitive decline, immune dysfunction, and chronic diseases. While pharmacological and cognitive-beha

Z Ziheng Liang