Prevalence of Left Ventricular Diastolic Dysfunction and Prognostic Value in Septic Shock Patients According to Different Guidelines: Comparison Between Contemporary Cardiological Algorithms and Simplified Approaches

Echocardiography. 2026 Sep;43(9):e70638. doi: 10.1111/echo.70638.ABSTRACTBACKGROUND: Diagnosis of left ventricular diastolic dysfunction (LVDD) in the context of septic shock is challenging. We aimed to compare different algorithms applied to septic patients.METHODS: Secondary analysis of a prospect

F Filipe A Gonzalez

One million exomes identify FNIP1 as a metabolic brake

Trends Genet. 2026 Sep 25:S0168-9525(26)00223-4. doi: 10.1016/j.tig.2026.09.003. Online ahead of print.ABSTRACTExome sequencing of more than 1 million people uncovered dozens of genes linked to the biomarker of the body's energy state (Hindy et al.). Rare loss-of-function variants in FNIP1, a suppre

N Nobuyuki Enzan

Geographic variation in the diagnosis of cardiomyopathies in a universal healthcare system: a nationwide study of hypertrophic and arrhythmogenic right ventricular cardiomyopathy in Denmark

Open Heart. 2026 Sep 25;13(2):e004493. doi: 10.1136/openhrt-2026-004493.ABSTRACTBACKGROUND: In Denmark, hypertrophic cardiomyopathy (HCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC) are primarily diagnosed and managed in specialised inherited cardiac disease clinics, making them suita

P Priya Bhardwaj

Study on blueberries, protein and exercise for improving frailty and cardiovascular disease (STRONG): protocol for a parallel-group randomised controlled superiority trial in older Nova Scotians

BMJ Open. 2026 Sep 25;16(9):e114286. doi: 10.1136/bmjopen-2025-114286.ABSTRACTINTRODUCTION: As frailty and cardiovascular disease are closely linked, lifestyle interventions to reduce frailty could improve cardiovascular health in at-risk individuals. Previous clinical trials have shown that exercis

L Leah E Cahill

Berberine induces pleiotropic beneficial effects via hormesis

Pharmacol Res. 2026 Sep 25:109638. doi: 10.1016/j.phrs.2026.109638. Online ahead of print.ABSTRACTBerberine is a phytochemical that has been shown to prevent a spectrum of serious ailments, to slow aging, and to extend lifespans and health spans of animals, demonstrating its pleiotropic effectivenes

E Edward J Calabrese

The rhythm of pressure: Circadian disruption and chronotherapy

Pharmacol Ther. 2026 Sep 25:109127. doi: 10.1016/j.pharmthera.2026.109127. Online ahead of print.ABSTRACTDisruption of circadian blood pressure (BP) rhythm is a key pathophysiological feature and an important marker of cardiovascular risk. Ambulatory BP monitoring, the gold standard for assessing BP

K Kan Gao