Ann Neurol. 2026 Jun 17. doi: 10.1002/ana.78282. Online ahead of print.ABSTRACTOBJECTIVE: Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene-targeting strategies have thus far failed in clinical trials. Exercise remains the only inte
J Foot Ankle Res. 2026 Jun;19(2):e70176. doi: 10.1002/jfa2.70176.ABSTRACTINTRODUCTION: People at risk of diabetes-related foot ulcers are recommended to always use therapeutic footwear when weight-bearing, to help prevent ulcers. These recommendations are supported by good quality evidence, yet adhe
A detailed, spatially resolved quantitative map of the human proteome is essential for a deeper understanding of human biology and disease^(1-4). Here we present a comprehensive human proteomic landscape, generated by profiling more than 13,000 proteins across 2,856 samples using data-independent ac
No abstractNat Rev Neurol. 2026 Jun 17. doi: 10.1038/s41582-026-01228-5. Online ahead of print.NO ABSTRACTPMID:42310397 | DOI:10.1038/s41582-026-01228-5
Nat Aging. 2026 Jun 17. doi: 10.1038/s43587-026-01140-z. Online ahead of print.ABSTRACTThroughout the female reproductive lifespan, the ovary undergoes hundreds of cycles of follicle development, ovulation and tissue regeneration. How aging disrupts the coordination of such precise, multicellular in
Int J Obes (Lond). 2026 Jun 17. doi: 10.1038/s41366-026-02133-z. Online ahead of print.ABSTRACTBACKGROUND: Normal weight obesity (NWO) is characterized by a normal body mass index (BMI) and elevated body fat. Heterogeneous risk has been observed in people with obesity (BMI > 30) when considering met
Int J Obes (Lond). 2026 Jun 17. doi: 10.1038/s41366-026-02128-w. Online ahead of print.ABSTRACTMetabolic disorders-particularly obesity and type 2 diabetes mellitus (T2DM)-have reached pandemic proportions and represent one of the most pressing global health challenges of the 21st century. Peroxisom
Hypertens Res. 2026 Jun 17. doi: 10.1038/s41440-026-02706-5. Online ahead of print.ABSTRACTAbnormal phosphate homeostasis is associated with inflammation, vascular calcification, and endothelial dysfunction in chronic kidney disease (CKD). Apparent treatment-resistant hypertension (ATRH) is common i
Sci Rep. 2026 Jun 17;16(1):18866. doi: 10.1038/s41598-026-57087-z.ABSTRACTDiabetic nephropathy (DN), indicated by persistent urinary albumin excretion or albuminuria, is the major cause of end stage renal disease worldwide. Currently albuminuria is considered the best predictor of subsequent develop
Sci Rep. 2026 Jun 17;16(1):18861. doi: 10.1038/s41598-026-52864-2.ABSTRACTDiabetic Foot Ulcers are a severe complication of diabetes that can lead to infection, amputation, and increased mortality, making timely and objective assessment essential. Conventional evaluation relies primarily on visual i
Ann Surg Oncol. 2026 Jun 17. doi: 10.1245/s10434-026-19946-x. Online ahead of print.ABSTRACTBACKGROUND: While neoadjuvant immunochemotherapy has improved outcomes of resectable nonsmall cell lung cancer (NSCLC), treatment-induced tissue changes can increase surgical complexity. This study aimed to i
Mol Neurobiol. 2026 Jun 18;63(1):700. doi: 10.1007/s12035-026-06001-9.ABSTRACTStroke, primarily due to ischemic injury and neurodegeneration, is a significant global cause of death and permanent neurological impairment in adults. Phytocompounds are promising candidates for stroke care because of the
Commun Biol. 2026 Jun 17. doi: 10.1038/s42003-026-10503-6. Online ahead of print.ABSTRACTDiastolic dysfunction, defined by impaired relaxation and increased ventricular stiffness, is central to heart failure with preserved ejection fraction, yet cardiomyocyte-intrinsic mechanisms remain incompletely
NPJ Precis Oncol. 2026 Jun 17;10(1):230. doi: 10.1038/s41698-026-01555-2.ABSTRACTFunctional precision oncology (FPO) enables individualized therapy selection using patient-derived tumor models, yet the concordance of distinct ex vivo testing strategies remains unclear. Here, we compare two orthogona
NPJ Digit Med. 2026 Jun 17. doi: 10.1038/s41746-026-02904-y. Online ahead of print.ABSTRACTAcute coronary syndrome triage at first medical contact begins with patient narratives, while definitive diagnosis often requires waiting for cardiac troponin or electrocardiogram results. We developed TriageM
NPJ Precis Oncol. 2026 Jun 18. doi: 10.1038/s41698-026-01567-y. Online ahead of print.ABSTRACTAccurate assessment of protein translation is crucial for understanding disease variant functions, but mRNA-protein discrepancy limits transcriptomics-based clinical oncology. While ribosome profiling direc
No abstractPediatr Nephrol. 2026 Jun 17. doi: 10.1007/s00467-026-07414-3. Online ahead of print.NO ABSTRACTPMID:42310059 | DOI:10.1007/s00467-026-07414-3
Sci Rep. 2026 Jun 17. doi: 10.1038/s41598-026-55619-1. Online ahead of print.ABSTRACTDyslipidaemia and hypertension are significant independent risk factors for cardiovascular disease, and the two mostly exist together in clinical cases. This study aimed to determine the socio-demographic and clinic
No abstractSci Rep. 2026 Jun 17;16(1):18865. doi: 10.1038/s41598-026-58304-5.NO ABSTRACTPMID:42310053 | DOI:10.1038/s41598-026-58304-5
Sci Rep. 2026 Jun 17. doi: 10.1038/s41598-026-55028-4. Online ahead of print.ABSTRACTAge-related macular degeneration (AMD) and cardiovascular disease (CVD) share numerous risk factors; however, protein biomarkers for AMD are lacking. We investigated whether circulating cardiovascular peptide biomar
Sci Rep. 2026 Jun 17. doi: 10.1038/s41598-026-54340-3. Online ahead of print.ABSTRACTPanax notoginseng is a traditional Chinese medicinal rich in saponins, polysaccharides and flavonoids, which have significant therapeutic effects on cardiovascular and cerebrovascular diseases. Climate change has le
Nat Commun. 2026 Jun 17;17(1):5359. doi: 10.1038/s41467-026-73993-2.ABSTRACTRecent advances in mitochondrial network dynamic and signalling highlight mitochondria as key therapeutic targets across diverse diseases. Yet, high drug development failure rates reflect an incomplete understanding of upstr
Alzheimers Dement. 2026 Jun;22(6):e71583. doi: 10.1002/alz.71583.ABSTRACTINTRODUCTION: White matter hyperintensities (WMHs) are a robust marker of brain aging and dementia risk, typically attributed to vascular pathology. However, impaired astrocytic support may also contribute. The locus coeruleus
Alzheimers Dement. 2026 Jun;22(6):e71538. doi: 10.1002/alz.71538.ABSTRACTVascular contributions to cognitive impairment and dementia (VCID) are common in older adults and are typically associated with cerebral small vessel disease (cSVD). However, little remains known about non-pharmacological, modi
