Inhaled sphingosine reduces bronchial Pseudomonas aeruginosa burden during porcine ex vivo lung perfusion and shows tissue delivery in explanted human lungs

Sci Rep. 2026 Aug 6;16(1):24315. doi: 10.1038/s41598-026-65074-7.ABSTRACTPseudomonas aeruginosa infection remains a major challenge in donor lung management and post-transplant respiratory care, particularly in the setting of antimicrobial resistance. Ex vivo lung perfusion (EVLP) provides an opport

Y Yongjie Liu

MITF Regulates CFTR Expression to Participate in Myocardial Ischemia-Reperfusion Injury

J Gene Med. 2026 Aug;28(8):e70102. doi: 10.1002/jgm.70102.ABSTRACTBACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) remains a major clinical problem, and its regulatory mechanisms are not fully defined. This study aimed to identify key MIRI-related targets and clarify their roles in cellular

B Baoxin Tang

Three-dimensional simulations for planning fenestrated/branched endografts in endovascular aneurysm repair for complex abdominal aortic aneurysm: a retrospective cohort study

Ther Adv Cardiovasc Dis. 2026 Jan-Dec;20:17539447261457539. doi: 10.1177/17539447261457539. Epub 2026 Aug 6.ABSTRACTBACKGROUND: Endovascular aneurysm repair (EVAR) is used to treat patients with abdominal aortic aneurysm (AAA) who have suitable anatomy, while complex AAAs often require fenestrated a

Y Yujing Zhang

Explainable temporal machine learning of multimorbidity trajectories after acute myocardial infarction: complementing clinical risk scores with mechanistic phenotypes

J Am Med Inform Assoc. 2026 Aug 6:ocag135. doi: 10.1093/jamia/ocag135. Online ahead of print.ABSTRACTOBJECTIVE: This study aimed to identify trajectories of multimorbidity following acute myocardial infarction (AMI), using explainable temporal machine-learning methods, and assess their clinical, pro

A Anthony Onoja

Efficacy and safety of deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in patients with active psoriatic arthritis: 52-week results from the randomised, double-blind, placebo-controlled phase 3 POETYK PsA-1 trial

Ann Rheum Dis. 2026 Aug 6:S0003-4967(26)00340-7. doi: 10.1016/j.ard.2026.05.029. Online ahead of print.ABSTRACTOBJECTIVES: The randomised, double-blind, placebo-controlled, phase 3 Program fOr Evaluation of TYK2 inhibitor Psoriatic Arthritis-1 (POETYK PsA-1) trial evaluated the efficacy, safety, and

D Désirée van der Heijde

Precise nanodelivery of screened compounds alleviates sepsis-associated encephalopathy by targeting microglial ANXA2

Sci Bull (Beijing). 2026 Jul 23:S2095-9273(26)00840-6. doi: 10.1016/j.scib.2026.07.059. Online ahead of print.ABSTRACTSepsis frequently induces sepsis-associated encephalopathy (SAE), which lacks targeted therapies and often results in persistent neurobehavioral deficits. Here, we developed a transl

D Daoyi Lin

Prediction of Incident Atrial Fibrillation and Association With Outcomes Using Routine Electronic Health Records in a Western Pacific Population

Heart Lung Circ. 2026 Aug 6:S1443-9506(26)00213-1. doi: 10.1016/j.hlc.2026.03.062. Online ahead of print.ABSTRACTBACKGROUND AND AIM: Atrial fibrillation (AF) affects over 37 million people internationally and confers increased risk of cardiovascular conditions. Prediction algorithms have attempted t

J Jung-Chi Hsu

Heart-on-a-Chip: Theory, Evidence, and Personalised Medicine

Heart Lung Circ. 2026 Aug 6:S1443-9506(26)00211-8. doi: 10.1016/j.hlc.2026.03.060. Online ahead of print.ABSTRACTCardiovascular research traditionally relies on animal models or isolated cell cultures, each having limitations in accurately mimicking human heart function and disease. Organ-on-chip te

P Priya Joshi

Athletes and the coronary calcium paradox

No abstractBr J Sports Med. 2026 Aug 6:bjsports-2025-111309. doi: 10.1136/bjsports-2025-111309. Online ahead of print.NO ABSTRACTPMID:42562617 | DOI:10.1136/bjsports-2025-111309

S Shaun Khanna

Association of Positive airway pressure adherence with mortality and cardiovascular events in high vs low risk sleep apnoea patients

Eur Respir J. 2026 Aug 6:2600531. doi: 10.1183/13993003.00531-2026. Online ahead of print.ABSTRACTBACKGROUND: Positive airway pressure (PAP) has shown inconsistent effects on cardiovascular (CV) outcomes in obstructive sleep apnoea (OSA). Physiological biomarkers derived from sleep studies such as s

S Sébastien Bailly

Risk-of-bias assessment in prognostic cohort studies: a methodological comparison study of structured appraisal tools in acute pulmonary embolism research

BMJ Open. 2026 Aug 6;16(8):e113000. doi: 10.1136/bmjopen-2025-113000.ABSTRACTOBJECTIVES: To compare the reliability of four commonly used structured tools for risk-of-bias assessment in prognostic cohort studies and evaluate their agreement with expert appraisal.DESIGN: Methodological comparison stu

L Ludovica Anna Cimini

Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity

Genes Dev. 2026 Aug 6. doi: 10.1101/gad.353559.125. Online ahead of print.ABSTRACTLongevity and stress resilience require precise coordination of gene expression programs across tissues. Here, we demonstrate that overexpression of the chromatin reader bet-1 specifically in neurons of Caenorhabditis

N Naibedya Dutta

Family-based interventions for optimal lipid outcomes in adults: A cluster randomized controlled trial in India

J Clin Lipidol. 2026 Jul;20(7):1456-1463. doi: 10.1016/j.jacl.2026.01.003. Epub 2026 Mar 13.ABSTRACTBACKGROUND: Dyslipidemia substantially increases the risk of cardiovascular disease (CVD), particularly among those with a strong family history.OBJECTIVE: To evaluate the longitudinal impact of the P

P Panniyammakal Jeemon

Extensive venous thromboembolism secondary to uterine fibroid compression of the inferior vena cava

BMJ Case Rep. 2026 Aug 6;19(8):e271975. doi: 10.1136/bcr-2025-271975.ABSTRACTA woman in her 40s presented with a 2-day history of progressive left lower limb swelling and dyspnoea. She had a background of heavy menstrual bleeding and previously underwent insertion of an intrauterine device 2 years e

P Paddy Murphy

Paediatric midaortic syndrome associated with ascending aortic and renal aneurysm managed with complex multidisciplinary medical management and surgical repair

BMJ Case Rep. 2026 Aug 6;19(8):e266584. doi: 10.1136/bcr-2025-266584.ABSTRACTWe present the case of an otherwise previously healthy female in middle childhood with severe renovascular hypertension secondary to midaortic syndrome with ascending aortic dilation. She presented with hypertensive emergen

E Eden Sophia Singh

Menopause cardiovascular health and the role of hormone therapy

Aust J Gen Pract. 2026 Aug;55(8):521-527. doi: 10.31128/AJGP-10-25-7874.ABSTRACTBACKGROUND: The menopause transition marks a period of accelerated cardiovascular risk in women, highlighting the importance of opportunistic screening and intervention in midlife primary care.OBJECTIVE: This article sum

T Tegan Burns

Diagnostic value of cerebrospinal fluid antisuprabasin antibody in neuropsychiatric systemic lupus erythematosus

Lupus Sci Med. 2026 Aug 6;13(2):e002144. doi: 10.1136/lupus-2026-002144.ABSTRACTBACKGROUND: Diagnostic attribution of neuropsychiatric symptoms in SLE (NPSLE) remains challenging. This study evaluated whether cerebrospinal fluid (CSF) antisuprabasin (SBSN) antibody can serve as a diagnostic biomarke

F Fan Zhang

Occurrence of venous thromboembolism in SLE: findings from a nationwide cohort and a clinical cohort in Sweden

Lupus Sci Med. 2026 Aug 6;13(2):e002058. doi: 10.1136/lupus-2026-002058.ABSTRACTOBJECTIVES: To estimate the risk of venous thromboembolism (VTE) in a nationwide cohort of newly diagnosed patients with SLE and in a cohort of established patients with SLE at Karolinska University Hospital compared wit

T Tamara Vojinovic

AI-Based Phenotyping of Atrial Fibrillation Through Generative Topographic Mapping: Prospective Murcia Atrial Fibrillation Project III Cohort Study

J Med Internet Res. 2026 Aug 6;28:e90502. doi: 10.2196/90502.ABSTRACTBACKGROUND: The clinical heterogeneity of atrial fibrillation (AF) challenges current classifications and risk scores, limiting their real-world applicability. AI-driven methods may enhance phenotyping and risk stratification.OBJEC

E Eva Soler Espejo

Sources of Active Brain White Matter Injury in Virally Suppressed HIV Infection Revealed Through Fixel-Based Analysis

J Acquir Immune Defic Syndr. 2026 Aug 6. doi: 10.1097/QAI.0000000000003946. Online ahead of print.ABSTRACTBACKGROUND: To better understand HIV and cardiovascular disease (CVD) effects on brain white matter during HIV infection, advanced diffusion imaging and comprehensive predictor analyses are esse

D David Jakabek

Effectiveness, Efficacy, and Safety of Home-Based Cardiac Rehabilitation Following Valve Replacement or Repair: Protocol for a Systematic Review

JMIR Res Protoc. 2026 Aug 6;15:e86832. doi: 10.2196/86832.ABSTRACTBACKGROUND: Cardiac rehabilitation (CR) is recommended following valve replacement or repair procedures (VRPs), yet participation remains suboptimal among patients undergoing VRPs. Home-based CR (HBCR), including both fully digital an

M Mohammed Ferid Gharad

Macular atrophy in neovascular age-related macular degeneration: Prevalence, risk factors, imaging features, and clinical implications

Surv Ophthalmol. 2026 Aug 6:S0039-6257(26)00116-5. doi: 10.1016/j.survophthal.2026.08.002. Online ahead of print.ABSTRACTMacular atrophy (MA) is a major cause of long-term visual decline in neovascular age-related macular degeneration (nAMD), despite the ability of anti-vascular endothelial growth f

X Xuenan Zhuang

Association of serial neutrophil-to-lymphocyte ratio trajectories with clinical risk profiles and one-year outcomes in patients with Takotsubo syndrome

Int J Cardiol. 2026 Aug 6:134717. doi: 10.1016/j.ijcard.2026.134717. Online ahead of print.ABSTRACTBACKGROUND: Takotsubo syndrome (TTS) is a heterogeneous acute cardiac syndrome associated with substantial early complications and adverse long-term outcomes. Although admission neutrophil-to-lymphocyt

J Jordi Sans-Roselló

Assessment and validation of the established free-running framework for cardiac function by magnetic resonance imaging at 1.5T (FAST-CMR): an international multi-center, multi-vendor study

J Cardiovasc Magn Reson. 2026 Aug 6:102784. doi: 10.1016/j.jocmr.2026.102784. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular magnetic resonance (CMR) is the reference standard for assessing cardiac function, yet its widespread clinical use remains challenged by time-intensive workflows req

K Katerina Eyre