Decoding the CRH system from clinical failures to therapeutic translation

Trends Endocrinol Metab. 2026 Aug 28:S1043-2760(26)00206-7. doi: 10.1016/j.tem.2026.08.002. Online ahead of print.ABSTRACTThe corticotropin-releasing hormone (CRH) system orchestrates stress adaptation, integrating neuroendocrine, autonomic, immune, and behavioural responses to internal and external

M Maria Pinheiro Da Silva

Performance and label efficiency of traditional deep-learning models and a retina-specific foundation model for ocular and systemic disease detection: a retrospective comparative study

Lancet Digit Health. 2026 Aug 28:101031. doi: 10.1016/j.landig.2026.101031. Online ahead of print.ABSTRACTBACKGROUND: RETFound, a self-supervised retina-specific foundation model, has shown potential in downstream tasks, but its performance in comparison with that of traditional deep-learning models

S Samantha Min Er Yew

An Improved Rat Model of Myocardial Infarction Without Invasive Intubation

In Vivo. 2026 Sep-Oct;40(5):2652-2662. doi: 10.21873/invivo.14419.ABSTRACTBACKGROUND/AIM: The standard surgical procedure for inducing myocardial infarction (MI) in rat models via left anterior descending (LAD) coronary artery ligation typically requires invasive endotracheal intubation. While recen

K Khoirur Rijal Ashsholih

The Dietary Inflammatory Index is Lower Among Healthy Older Adults Consuming a Walnut-Supplemented Diet. Ancillary Results from the Walnuts and Healthy Aging Randomized Controlled Trial

J Acad Nutr Diet. 2026 Aug 28:156835. doi: 10.1016/j.jand.2026.156835. Online ahead of print.ABSTRACTBACKGROUND: Walnuts may lower diet-related inflammation by providing anti-inflammatory compounds and displacing pro-inflammatory nutrients.OBJECTIVE: To explore the association between daily walnut c

L Lynnley Huey Stern

Safety and lipoprotein(a)-lowering effects of Kylo-11, a non-canonical, long-duration small interfering RNA targeting lipoprotein(a): a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial

Lancet. 2026 Aug 28:S0140-6736(26)01484-4. doi: 10.1016/S0140-6736(26)01484-4. Online ahead of print.ABSTRACTBACKGROUND: Elevated lipoprotein(a) concentrations are associated with the development of atherosclerotic cardiovascular disease. The aim of this study was to evaluate the safety and lipoprot

A Ashish Sarraju