Inflammation and Immunogenetics in Cardiomyopathies: From Molecular Mechanisms to Therapeutic Perspectives

Immunol Rev. 2026 Mar;338(1):e70105. doi: 10.1111/imr.70105.ABSTRACTGenetic variants that impair cardiac function or predispose individuals to autoimmune diseases can influence both the risk and severity of inflammatory heart diseases, including lymphocytic myocarditis and cardiac sarcoidosis. We re

G Giovanni Peretto

From Signaling Pathways to Combination Therapy: Bioactive Compounds against Cancer Stem Cells

Stem Cell Rev Rep. 2026 Feb 2. doi: 10.1007/s12015-026-11057-0. Online ahead of print.ABSTRACTCancer Stem Cells (CSCs) represent a heterogeneous group of tumor cells that possess the innate ability to self-renew and differentiate, which also contributes to their resistance to first-line therapies. W

P P S V V Charan

The emerging role of calsequestrin 2: from calcium sensor and modulator to arrhythmia driver

Calsequestrin 2 (CASQ2) has emerged as a central sensor and modulator of calcium (Ca^(2+)) dynamics in sarcoplasmic reticulum (SR), influencing both health and disease. This review explores the molecular architecture and multifunctional roles of CASQ2, beginning with its domain organization and Ca^(

H Humam Emad Rajha

Cobalt-Induced Cardiomyopathy: Mitochondrial Dysfunction, Oxidative Stress, and Reversible Cardiac Toxicity: A Systematic Review

Cardiovasc Toxicol. 2026 Feb 2;26(2):24. doi: 10.1007/s12012-026-10099-7.ABSTRACTMetal-on-metal (MoM) joint replacements were designed to improve durability in younger, active patients. However, cobalt-induced cardiomyopathy (CIC) has emerged as a rare but serious complication, often misattributed t

D Darshan Hullon

CD95 ligand drives abdominal aortic aneurysm progression through Caspase-8-mediated GSDMD-dependent endothelial pyroptosis: modulation by SRC kinase

Apoptosis. 2026 Feb 2;31(2):60. doi: 10.1007/s10495-026-02263-9.ABSTRACTAbdominal aortic aneurysm (AAA) progression is closely linked to inflammation and endothelial dysfunction. Our previous study has demonstrated that increased CD95 ligand (CD95L) and its downstream effector Caspase-8 in the aorti

T Tian-Tian Ke

Drug-induced hypertension is associated with improved survival in glioblastoma patients treated with bevacizumab: evidence from a time-to-event meta-analysis and meta-regression

Neurosurg Rev. 2026 Feb 2;49(1):186. doi: 10.1007/s10143-025-04088-7.ABSTRACTBevacizumab only improves progression-free survival (PFS) but not overall survival (OS) in glioblastoma (GBM) patients. Drug-induced hypertension is a common adverse event associated with bevacizumab in GBM, and it may para

I Irfan Kesumayadi

Immature leukocyte and plasma-induced cell death reveal subclinical immune activation in EGPA patients in remission

Inflamm Res. 2026 Feb 2;75(1):31. doi: 10.1007/s00011-026-02189-7.ABSTRACTOBJECTIVE: ANCA-associated vasculitis (AAV) is a group of rare autoimmune diseases characterized by pauci-immune necrotizing inflammation of small to medium-sized blood vessels, in which ANCAs targeting neutrophil antigens pro

C Chiara Baggio

Evaluation of heat warning thresholds with multiple lagged and cumulative health impacts based on a 20-year population database

Sci Rep. 2026 Feb 1. doi: 10.1038/s41598-025-31832-2. Online ahead of print.ABSTRACTHeat warning systems represent a critical health adaptation strategy under global boiling. This study evaluates the appropriateness of the existing criteria of heat warning categories, which were established based on

S Shih-Chun Candice Lung

Extracorporeal cardiac shock wave stimulation enhances the therapeutic efficacy of intravenously delivered endothelial colony-forming cells via PI3K/AKT signaling in a rat myocardial infarction model

Stem Cell Res Ther. 2026 Feb 1. doi: 10.1186/s13287-026-04913-w. Online ahead of print.ABSTRACTBACKGROUND: Extracorporeal cardiac shock wave (ECSW) therapy enhances the function of endothelial colony-forming cells (ECFCs), but whether it can serve as a preconditioning strategy to enhance myocardial

M Mingqiang Wang

Inflammation-induced impairment of synaptic plasticity accelerates atherosclerosis co-depression disease: insights from bioinformatics analysis and transcriptomics

Cell Biosci. 2026 Feb 1. doi: 10.1186/s13578-026-01535-w. Online ahead of print.ABSTRACTBACKGROUND: Atherosclerosis (AS) serves as the pathological foundation for numerous cardiovascular and cerebrovascular diseases and is highly comorbid with depression. The mechanisms underlying this co-morbidity

Y Yulong Zhao

STING deficiency alleviates scar formation after glaucoma filtration surgery by suppressing p38 MAPK-induced inflammation in mice

Eye Vis (Lond). 2026 Feb 2;13(1):7. doi: 10.1186/s40662-026-00475-3.ABSTRACTBACKGROUND: Glaucoma filtration surgery (GFS) often fails because of excessive scar formation driven by inflammation and fibroblast activation. Although the stimulator of interferon genes (STING) pathway is involved in infla

H Huifang Ye

Association of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality among individuals incardiovascular-kidney-metabolic syndrome stages 0-3: a cohort study from the NHANES 2001-2018

Diabetol Metab Syndr. 2026 Feb 1. doi: 10.1186/s13098-026-02099-y. Online ahead of print.ABSTRACTBACKGROUND: The association between vitamin D status and mortality risk among adults with cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3 requires further elucidation. We investigated the relat

Y Yanni Zhao

Association of fenofibrate therapy with cardiovascular events and mortality in diabetes patients with early-diagnosed hyperlipidemia

No abstractLipids Health Dis. 2026 Feb 1. doi: 10.1186/s12944-026-02877-7. Online ahead of print.NO ABSTRACTPMID:41622209 | DOI:10.1186/s12944-026-02877-7

H Huidan Liu

Effects of cardiopulmonary bypass on in vitro proliferation of human pancreatic cancer cells and plasma growth factor levels

J Cardiothorac Surg. 2026 Feb 1. doi: 10.1186/s13019-026-03860-0. Online ahead of print.ABSTRACTBACKGROUND: Advances in medicine lead to an increase in the number of patients with concurrent heart disease and cancer. We investigated the effect of cardiac surgery under cardiopulmonary bypass (CPB) on

S Seidai Katagiri

Sex-specific cardiovascular risk in estrogen-treated androgen-deprived males: metabolic characterization of glucose, adipose, and lipid pathways

Cardiovasc Diabetol. 2026 Feb 2. doi: 10.1186/s12933-025-03059-y. Online ahead of print.ABSTRACTBACKGROUND: Estrogen therapy and androgen‑deprivation were once combined to treat prostate cancer (PrCa). Clinical studies later showed that prolonged estrogen exposure in androgen‑deprived men raises car

A Ariel S Thorson

Associations of insulin resistance-related indices with incident carotid plaques by cardiovascular risk profiles: a prospective cohort study

No abstractLipids Health Dis. 2026 Feb 2. doi: 10.1186/s12944-026-02881-x. Online ahead of print.NO ABSTRACTPMID:41622187 | DOI:10.1186/s12944-026-02881-x

P Peiyao Liu

Prevalence and treatment and control rates of hypertension among Chinese adults from 2016 to 2022: a meta-analysis

BMC Public Health. 2026 Feb 2. doi: 10.1186/s12889-026-26430-4. Online ahead of print.ABSTRACTBACKGROUND: Hypertension is a leading cause of cardiovascular and cerebrovascular disease-related morbidity and mortality. This study aimed to investigate the prevalence, treatment rate and control rate of

D Dong-Yue Qi

Diffusing capacity for carbon monoxide is significantly associated with cardiovascular disease-related plasma proteins, independently of obstruction

CONCLUSIONS: Several CVD-linked plasma proteins were associated with D(LCO) in subjects without airflow obstruction on spirometry and after adjustments for known cardiovascular morbidity. The likely explanations may be the pro-fibrotic and pro-inflammatory nature of many of the proteins causing chan

S Suneela Zaigham

Effectiveness of Mobile Health Technology-Based Interventions on Foot Care Behaviors, Knowledge and Beliefs in Patients With Diabetes: A Systematic Review and Meta-Analysis

Nurs Health Sci. 2026 Mar;28(1):e70295. doi: 10.1111/nhs.70295.ABSTRACTMobile Health (mHealth) technology offers the potential to improve healthcare quality. This study aims to evaluate the effectiveness of mHealth interventions on the foot care behaviors, knowledge, and beliefs of patients with dia

L Luwen Zhang

Dietary Advanced Glycation End Products (dAGEs): Pathogenesis and nutritional strategies for health longevity-A critical view

Nutr Metab Cardiovasc Dis. 2025 Dec 30:104538. doi: 10.1016/j.numecd.2025.104538. Online ahead of print.ABSTRACTAdvanced Glycation End Products (AGEs), formed through the non-enzymatic Maillard reaction, are pivotal molecular culprits linking metabolic dysfunction, chronic disease, and the accelerat

P Paola Russo

Corrigendum to "Bufalin alleviates myocardial ischemia-reperfusion injury by targeting PTGR2 to regulate NF-κB mediated inflammation" [Biomed. Pharmacother., 2025 Dec; 193:118895]

No abstractBiomed Pharmacother. 2026 Jan 31:119083. doi: 10.1016/j.biopha.2026.119083. Online ahead of print.NO ABSTRACTPMID:41622092 | DOI:10.1016/j.biopha.2026.119083

J Jinlin Hu

Exploratory genome-wide analysis suggests potential associations of PPP1R12B, FSTL5, G5K3B, and GFRA2 loci with a derived HDL functionality score

J Clin Lipidol. 2026 Jan 12:S1933-2874(26)00003-6. doi: 10.1016/j.jacl.2026.01.004. Online ahead of print.ABSTRACTBACKGROUND: The size, composition, and functionality of high-density lipoprotein cholesterol (HDL-C) are potential biomarkers for predicting atherosclerosis, representing a major advance

R Ribanna A M Braga

Citronellal Alleviates Myocardial Senescence by Enhancing Mitochondrial Autophagy via AMPKα-PINK1/Parkin Pathway

Phytother Res. 2026 Feb 1. doi: 10.1002/ptr.70241. Online ahead of print.ABSTRACTCardiomyocyte senescence contributes to the progression of multiple cardiac diseases, with oxidative stress identified as a central pathophysiological mechanism. Previous animal experiments demonstrated that citronellal

Y Yi-Wen Qian

Do maternal and neonatal outcomes differ with single or twin pregnancies affected by hypertensive disorders? A systematic review and meta-analysis

J Matern Fetal Neonatal Med. 2026 Dec;39(1):2618389. doi: 10.1080/14767058.2026.2618389. Epub 2026 Feb 1.ABSTRACTOBJECTIVE: To compare maternal and neonatal outcomes of singleton and twin gestations complicated by hypertensive disorders of pregnancy (HDP).METHODS: PubMed, Cochrane Library, Scopus, W

Q Qingqing Shen