Plasma Proteomic Signatures for Early Risk Stratification Across Cardiovascular-Kidney-Metabolic Stages 0-2

Diabetes Obes Metab. 2026 Sep 30. doi: 10.1111/dom.71399. Online ahead of print.ABSTRACTAIMS: Cardiovascular-kidney-metabolic (CKM) stages 0-2 represent a potentially modifiable period before overt cardiovascular complications, yet molecular markers that identify individuals at higher downstream ris

X Xingyu Li

The Interplay Between Klotho, Aldosterone, and Vascular Damage in Chronic Kidney Disease: Insights from a Cross-Sectional Study

J Nephrol. 2026 Oct 1:aajag249. doi: 10.1093/joneph/aajag249. Online ahead of print.ABSTRACTBACKGROUND: Patients with chronic kidney disease (CKD) are at increased risk of vascular calcification and cardiovascular mortality. Reduced Klotho levels have been associated with vascular damage in CKD thro

L Lida Tartaglione

Gestational Weight Gain, Postpartum Weight Retention, and Women's Mid-Life Cardiovascular Health in Project Viva

Obesity (Silver Spring). 2026 Sep 30. doi: 10.1002/oby.70312. Online ahead of print.ABSTRACTOBJECTIVE: This study aimed to examine associations of gestational weight gain (GWG) and postpartum weight retention (PPWR) with women's mid-life cardiovascular health.METHODS: We studied 838 Project Viva par

B Benjamin Grobman

Intramuscular Fat as a Biomarker of Muscle Health: Strengths, Limitations and Open Challenges

J Cachexia Sarcopenia Muscle. 2026;17(5):e70389. doi: 10.1002/jcsm.70389.ABSTRACTIntramuscular fat (IMF), also known as myosteatosis, refers to the accumulation of lipids within and around skeletal muscle fibres. Excess IMF is increasingly recognised as a sign of poor muscle quality, linked to reduc

C Christopher Spence

Albumin Quality in Oxidative and Ischemic Stress: Implications for Drug Binding and Clinical Pharmacokinetics

Biol Pharm Bull. 2026;49(10):1579-1586. doi: 10.1248/bpb.b26-00232.ABSTRACTHuman serum albumin (HSA), the most abundant plasma protein, plays a critical role in transporting endogenous and exogenous ligands and drugs. Oxidative stress and ischemia induce structural modifications in HSA, including S-

S Shota Ichimizu

Errata: Difference in the Association between Growth Differentiation Factor 15 and Coronary Calcified Plaque According to Chronic Kidney Disease

Int Heart J. 2026;67(5):523. doi: 10.1536/ihj.67-5_Errata.ABSTRACTSeveral errors appeared in the article titled "Difference in the Association between Growth Differentiation Factor 15 and Coronary Calcified Plaque According to Chronic Kidney Disease" by Hayato Shimizu, Satoshi Hoshide, Hiroshi Funay

Incremental Value of 24-Hour Ambulatory Electrocardiogram-Derived Heart Rate Variability in Machine-Learning Prognostic Models for Heart Failure

Int Heart J. 2026;67(5):464-472. doi: 10.1536/ihj.26-215.ABSTRACTTo determine whether heart rate variability (HRV) indices derived from 24-hour ambulatory electrocardiography provide complementary prognostic information in machine-learning prognostic models using conventional clinical variables in p

Y Yuji Matsuwaki

Explainable Machine Learning Identifies Red Blood Cell Distribution Width as a Key Prognostic Biomarker in Cardiogenic Shock

Int Heart J. 2026;67(5):429-442. doi: 10.1536/ihj.25-604.ABSTRACTCardiogenic shock (CS) is a life-threatening syndrome characterized by severe pump failure and systemic hypoperfusion, with persistently high mortality. Red blood cell distribution width (RDW) has been associated with adverse outcomes

X Xueqian Shen

Variable hepatic and renal manifestations following grass carp gallbladder ingestion: a three-patient case series from Vietnam

J Toxicol Sci. 2026;51(10):527-532. doi: 10.2131/jts.51.527.ABSTRACTFish gallbladder ingestion remains a traditional folk remedy in several Asian countries but may result in severe hepatorenal toxicity. We report three patients admitted to the Poison Control Center, Bach Mai Hospital, Hanoi, Vietnam

N Nguyen Dang Duc

Emergent Total Endovascular Repair Using Retrograde in Situ Branched Stent Grafting for Ruptured Retrograde Aortic Dissection

Ann Thorac Cardiovasc Surg. 2026;32(1). doi: 10.5761/atcs.cr.26-00150.ABSTRACTAn 85-year-old bedridden woman (modified Rankin Scale 5) presented with a contained rupture of an acute retrograde aortic dissection (Type B0,7). Because open surgery was prohibitive due to severe frailty, an emergent tota

K Kenjiro Kaneko

Stage-Specific Cost-Effectiveness of Early vs. Delayed Tafamidis for Transthyretin Amyloid Cardiomyopathy in Japan

Circ J. 2026 Sep 29. doi: 10.1253/circj.CJ-26-0576. Online ahead of print.ABSTRACTBACKGROUND: Tafamidis improves survival in patients with transthyretin amyloid cardiomyopathy (ATTR-CM); however, its cost raises concerns regarding healthcare sustainability. We evaluated the stage-specific cost-effec

Y Yasufumi Nagata

A Case of Nephrotic Syndrome Developing Early After Initiation of Fruquintinib Therapy

Yakugaku Zasshi. 2026;146(10):895-900. doi: 10.1248/yakushi.26-00022.ABSTRACTFruquintinib (FRU) is a vascular endothelial growth factor receptor (VEGFR)-1, 2, 3 tyrosine kinase inhibitor (TKI) approved for metastatic colorectal cancer. While hypertension, fatigue, and hand-foot syndrome are common a

M Mika Urushima

Cell Death of Cardiomyocytes in Heart Failure

Yakugaku Zasshi. 2026;146(10):865-873. doi: 10.1248/yakushi.26-00113.ABSTRACTHeart failure, a leading cause of death worldwide, is generally defined as a pathophysiological condition in which the heart is unable to eject the arterial blood required by all tissues in the body. Heart failure is broadl

K Kouichi Tanonaka

Long-term renal, cardiovascular, and survival outcomes in patients with obesity and chronic kidney disease following metabolic and bariatric surgery: a propensity score-matched TriNetX real-world cohort study

Surg Obes Relat Dis. 2026 Aug 26:S1550-7289(26)00882-8. doi: 10.1016/j.soard.2026.08.015. Online ahead of print.ABSTRACTBACKGROUND: Obesity accelerates the progression of chronic kidney disease (CKD) and often limits access to kidney transplantation. Although metabolic and bariatric surgery (MBS) ha

P Pattharasai Kachornvitaya

Association of Cardiometabolic Index With Cardiometabolic Disease Prevalence and Mortality: Evidence From Two National Surveys

Heart Lung Circ. 2026 Sep 30:S1443-9506(26)00419-1. doi: 10.1016/j.hlc.2026.05.012. Online ahead of print.ABSTRACTBACKGROUND: The cardiometabolic index (CMI), a composite marker derived from the product of waist-to-height ratio and triglyceride-to- high-density lipoprotein cholesterol ratio, has eme

Z Zhen-Yu Liu

Coronary CT angiography: Diagnosis, prognosis and PCI planning

Ann Cardiol Angeiol (Paris). 2026 Sep 30:S0003-3928(26)00091-0. doi: 10.1016/j.ancard.2026.102086. Online ahead of print.ABSTRACTCoronary CT angiography (CCTA), long confined to a diagnostic triage role, now occupies a central place at every stage of coronary artery disease management. Diagnosticall

A Antoine Delapierre

Estimated small dense low-density lipoprotein cholesterol in predicting atherosclerotic cardiovascular disease: Longitudinal evidence from over 1 million Japanese adults

J Clin Lipidol. 2026 Sep 15:S1933-2874(26)00514-3. doi: 10.1016/j.jacl.2026.09.005. Online ahead of print.ABSTRACTBACKGROUND: Small dense low-density lipoprotein cholesterol (sdLDL-C) is an atherogenic LDL-C subfraction associated with atherosclerotic cardiovascular disease (ASCVD). Although sdLDL-C

K Koki Ono

From storm to stability: The role of plasmapheresis in the stabilization of patients with high-risk thyrotoxicosis

Endocrinol Diabetes Nutr (Engl Ed). 2026 Sep 30:501826. doi: 10.1016/j.endien.2026.501826. Online ahead of print.ABSTRACTINTRODUCTION: Thyrotoxicosis in high-risk patients is a severe condition requiring prompt management, although conventional therapeutic approaches often present limitations. Thera

A Agueda María Comisario

Epigenetic role of miR-574 in sperm chromatin remodeling and developmental gene networks in male infertility

Reprod Fertil Dev. 2026 Oct 15;38(15):RD26110. doi: 10.1071/RD26110.ABSTRACTCONTEXT: The epigenetic factors underlying varicocele and idiopathic infertility are still poorly understood, despite established pathophysiological mechanisms.AIMS: This study assessed sperm miR-574 expression in infertile

N Neslihan Hekim

The effects of therapeutic play on angiography procedures in children: a randomised controlled trial

Cardiol Young. 2026 Jul;36(7):1402-1408. doi: 10.1017/S104795112611378X. Epub 2026 Jul 7.ABSTRACTOBJECTIVE: This study investigated the effects of therapeutic play on angiography in children aged 4-10.METHODS: Our study was conducted as a randomised controlled experimental trial with 70 (experimenta

Y Yeliz Suna Dağ

Masked polycythaemia vera presenting with extensive splanchnic venous thrombosis and mesenteric ischaemia

BMJ Case Rep. 2026 Sep 30;19(9):e276448. doi: 10.1136/bcr-2026-276448.ABSTRACTSplanchnic venous thrombosis (SVT) is a potentially catastrophic manifestation of polycythaemia vera (PV). We report a woman in her 60s with masked PV who had been managed for 5 years with intermittent phlebotomy and aspir

R Rene A Amadore

Development and validation of an AI-enhanced prediction model for 3-year visual decline in patients with diabetes using ophthalmic imaging: protocol for a real-world longitudinal cohort study

BMJ Open. 2026 Sep 30;16(9):e123521. doi: 10.1136/bmjopen-2026-123521.ABSTRACTBACKGROUND: Diabetic retinopathy (DR) is one of the leading causes of visual impairment among working-age adults worldwide. Existing artificial intelligence (AI) studies have mainly focused on automated diagnosis and gradi

Y Yexian Yu

Performing lifestyle changes and reducing stroke risk: a process evaluation of a stroke prevention intervention

BMJ Open. 2026 Sep 30;16(9):e123012. doi: 10.1136/bmjopen-2026-123012.ABSTRACTOBJECTIVE: To examine the implementation process, mechanisms of change and contextual influences of a stroke prevention intervention.DESIGN: A process evaluation following the UK Medical Research Council's process evaluati

C Cecilia Johnsson

Perioperative Changes in Intra-Abdominal and Airway Pressure After Endoscopic Anterior Component Separation With Intraperitoneal Onlay Mesh Repair for Large Midline Incisional Hernia: A Prospective Observational Study

Asian J Endosc Surg. 2026 Jan-Dec;19(1):e70386. doi: 10.1111/ases.70386.ABSTRACTPURPOSE: Reduction of chronically herniated viscera and restoration of midline continuity in a large incisional hernia can raise intra-abdominal pressure (IAP), occasionally to the point of intra-abdominal hypertension.

M Meghna Purohit