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Cardiovascular disease

Disrupted erythrocyte S1P-eNOS axis promotes hypoxia, hypertension and fibrosis in obstructive sleep apnoea-hypopnoea syndrome

Eur Heart J. 2026 Jul 7:ehag405. doi: 10.1093/eurheartj/ehag405. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) has emerged as a global epidemic with profound cardiovascular and renal consequences, yet its early pathogenic mechanisms remain poo

Y Yuhua Fan

Activities and needs for training in nephrology: survey among geriatricians in France

Geriatr Psychol Neuropsychiatr Vieil. 2026 Jun 1;24(2):149-157. doi: 10.1684/pnv.2026.1271.ABSTRACTChronic kidney disease (CKD) prevalence increases with age and is frequently associated with geriatric syndromes. These situations may require close collaboration between nephrologists and geriatrician

L Léa Mésinèle

Ten-Year Cost Projections for Medicare Beneficiaries 65 Years or Older With HIV

JAMA Netw Open. 2026 Jul 1;9(7):e2621966. doi: 10.1001/jamanetworkopen.2026.21966.ABSTRACTIMPORTANCE: As the population of older people with HIV (PWH) in the US is growing, costs to Medicare are expected to rise substantially.OBJECTIVES: To project the number of Medicare beneficiaries aged 65 years

E Emily P Hyle

An Optimized Heart Failure Triaging Protocol to Reduce Avoidable Hospitalizations and Total Costs of Care

NEJM Catal Innov Care Deliv. 2026 Jan;7(1):CAT240478. doi: 10.1056/CAT.24.0478. Epub 2025 Dec 17.ABSTRACTHeart failure remains a leading cause of potentially avoidable hospital admissions throughout the United States and a significant driver of unnecessary, avoidable costs within value-based care pr

B Brandon W Danz

The relationship of apical periodontitis with chronic diseases and smoking habits: an umbrella review

Odontology. 2026 Jul 7. doi: 10.1007/s10266-026-01480-7. Online ahead of print.ABSTRACTGrowing evidence suggests a potential association between apical periodontitis (AP), chronic diseases, and smoking habits. However, findings from individual studies and systematic reviews remain fragmented, and hi

M Mohammed Alshehri

Targeting the Gut-Heart Axis in Atherosclerosis: Microbial Metabolites, Molecular Mechanisms, and Precision Therapeutics

Probiotics Antimicrob Proteins. 2026 Jul 7. doi: 10.1007/s12602-026-11124-5. Online ahead of print.ABSTRACTDespite advances in lipid-lowering and anti-inflammatory medications, atherosclerotic cardiovascular disease (ASCVD) continues to be the leading cause of morbidity and mortality worldwide. Rece

U Usha Adiga

Obstructive sleep apnea and rising cerebrovascular disease mortality in the United States, 1999-2020: A retrospective analysis

Sleep Breath. 2026 Jul 7;30(4):210. doi: 10.1007/s11325-026-03743-7.ABSTRACTBACKGROUND: The prevalence of obstructive sleep apnea (OSA) in the general population has been rising in recent years. OSA has not only been identified as an independent risk factor for cerebrovascular disease (CVD) but is a

F Fatima Zafar

Prognostic value of left atrial reservoir strain for major adverse cardiovascular events in coronary artery disease

J Echocardiogr. 2026 Jul 7. doi: 10.1007/s12574-026-00742-1. Online ahead of print.ABSTRACTCoronary artery disease (CAD) is associated with a high burden of long-term adverse cardiovascular events. Traditional risk stratification relies primarily on left ventricular ejection fraction, a measure limi

T Thitiphan Srikulmontri

Left ventricular excessive trabeculation: pathophysiology, diagnostic challenges, and prognostic significance

Heart Fail Rev. 2026 Jul 7;31(1):80. doi: 10.1007/s10741-026-10649-9.ABSTRACTExcessive trabeculation has been considered the morphological hallmark of left ventricular non-compaction (LVNC), traditionally viewed as a primary cardiomyopathy resulting from an arrest in myocardial compaction during emb

M Matteo Beltrami

Tachycardia-induced cardiomyopathy: evolution of the concept and contemporary insights

Heart Fail Rev. 2026 Jul 7;31(1):79. doi: 10.1007/s10741-026-10650-2.ABSTRACTTachycardia-induced cardiomyopathy (TIC) is a reversible form of myocardial dysfunction caused by sustained or recurrent tachyarrhythmias. Despite increasing recognition, its diagnosis and management remain challenging in c

N Naoki Sato

Long-term outcomes after resting full-cycle ratio and deferral of revascularization

Clin Res Cardiol. 2026 Jul 7. doi: 10.1007/s00392-026-02977-5. Online ahead of print.ABSTRACTBACKGROUND: Non-hyperemic pressure ratios are recommended to assess intermediate coronary lesions. Evidence on outcomes after deferral of revascularization based on resting full-cycle ratio (RFR) remains lim

S Stephan Nienaber

Ferumoxytol dose optimization for three-dimensional whole-heart magnetic resonance imaging in patients with congenital heart disease

Pediatr Radiol. 2026 Jul 7. doi: 10.1007/s00247-026-06706-y. Online ahead of print.ABSTRACTBACKGROUND: Ferumoxytol is used off-label as a contrast agent for cardiovascular magnetic resonance (CMR). However, the dose-response relationship between ferumoxytol, longitudinal relaxation, and image qualit

S Sukran Erdem

Complement Component C4B Prioritization Through Drug‒Target Mendelian Randomization and Proteomic Analysis Reveals a Novel Therapeutic Target for Calcific Aortic Valve Stenosis

Cardiovasc Drugs Ther. 2026 Jul 7. doi: 10.1007/s10557-026-07896-1. Online ahead of print.ABSTRACTOBJECTIVES: No pharmacotherapies effectively halt the progression of calcific aortic valve stenosis (CAVS). We leveraged multi-omic analyses to identify potential drug targets of CAVS.METHODS: We integr

W Weijie Li

Sotagliflozin pretreatment attenuates acute LPS-induced depression-like behavioral abnormalities and modulates the gut microbiota-immune-brain axis

Psychopharmacology (Berl). 2026 Jul 7. doi: 10.1007/s00213-026-07127-3. Online ahead of print.ABSTRACTRATIONALE: Inflammation-driven depression is increasingly recognized as a major therapeutic target, yet effective pharmacological strategies remain limited. Sotagliflozin (SOTA), a dual inhibitor of

J Jun Zeng

Pharmacokinetics of asciminib in a patient with chronic myeloid leukemia undergoing maintenance hemodialysis

Cancer Chemother Pharmacol. 2026 Jul 7;96(1):72. doi: 10.1007/s00280-026-04919-4.ABSTRACTAsciminib (ASC) is a novel BCR::ABL1 tyrosine kinase inhibitor that binds to the ABL myristoyl pocket. Although dose adjustments for renal impairment are generally considered unnecessary, pharmacokinetic data fo

M Maiko Abumiya

Clinical Utility of Single Ventricular Stroke Work Index for Predicting Prognosis in Patients with Functional Single Ventricle

Am J Physiol Heart Circ Physiol. 2026 Jul 7. doi: 10.1152/ajpheart.00948.2025. Online ahead of print.ABSTRACTStroke work of the ventricle is a parameter that integrates ventricular systolic and diastolic function. However, its clinical application in single-ventricle physiology has not been establis

R Rumi Haneda

Understanding One-year Mortality Rates and Comorbidity Burden in Older Adults Following Hip Fracture

Orthopedics. 2026 Jul 8:1-9. doi: 10.3928/01477447-20260608-01. Online ahead of print.ABSTRACTBACKGROUND: Hip fractures impose substantial patient morbidity and burden to health care systems globally, with potentially high and variable 1-year mortality rates. To improve shared decision making when g

C Chris Sun

Clinical Outcomes of Endoscopic Full-Thickness Resection Versus Laparoscopic and Endoscopic Cooperative Surgery: A Propensity Score-Matched Comparative Study

Dig Endosc. 2026 Jul;38(7):e70225. doi: 10.1111/den.70225.ABSTRACTOBJECTIVES: Endoscopic full-thickness resection (EFTR) and laparoscopic and endoscopic cooperative surgery (LECS) are minimally invasive treatments for gastric submucosal tumors (SMTs). Because comparative data of both methods are lac

Y Yoshiaki Ando

Association of Hemodynamic Disease Severity and Distribution With Risk of Future Acute Coronary Syndrome

CONCLUSIONS: Hemodynamic disease distribution, as measured by PPG(CT), complements FFR(CT) in predicting ACS risk. The integration of hemodynamic disease patterns provides additional prognostic value beyond lumen and plaque characteristics, with hemodynamic focal disease emerging as an independent p

S Seokhun Yang

Balloon-Assisted Stent Advancement Technique for Stent Delivery Failure in Complex Percutaneous Coronary Intervention

JACC Case Rep. 2026 Jul 6:109140. doi: 10.1016/j.jaccas.2026.109140. Online ahead of print.ABSTRACTOBJECTIVES: To describe a simple balloon-based maneuver-the balloon-assisted stent advancement technique-as a guide-extension-free alternative to facilitate stent delivery.KEY STEPS: Advance a second g

M Mustafa Tunahan Oz

Beyond galactose deficiency: redefining pathogenic IgA in IgA nephropathy

No abstractKidney Int. 2026 Jul 6:S0085-2538(26)00492-8. doi: 10.1016/j.kint.2026.05.014. Online ahead of print.NO ABSTRACTPMID:42412024 | DOI:10.1016/j.kint.2026.05.014

Y Yuemiao Zhang

Entropy for Prediction of MACEs in Myocarditis: A Cardiac MRI-based Biomarker of Myocardial Tissue Heterogeneity

Radiology. 2026 Jul;320(1):e251932. doi: 10.1148/radiol.251932.ABSTRACTBackground The prognostic value of left ventricular (LV) entropy in acute myocarditis is unclear. Purpose To assess the association of LV entropy, a measure of myocardial heterogeneity derived from cardiac MRI, with cardiovascula

Y Yining Wang

Evidence-informed approaches to medication management for opioid use disorder in special populations: a narrative review

J Addict Dis. 2026 Jul 7:1-11. doi: 10.1080/10550887.2026.2695127. Online ahead of print.ABSTRACTOpioid use disorder remains a critical public health challenge, marked by high prevalence, overdose deaths, and substantial societal burden. Despite the availability of effective medications for OUD (MOU

Z Zahraa Atoui

Blood pressure levels and clinically meaningful changes during inpatient rehabilitation after spinal cord injury: insights from the Dutch Spinal Cord Injury Database

Disabil Rehabil. 2026 Jul 7:1-12. doi: 10.1080/09638288.2026.2693411. Online ahead of print.ABSTRACTPURPOSE: To examine in individuals with spinal cord injury (SCI): associations of blood pressure (BP) with demographic, injury, and medication characteristics at admission; changes in BP and heart rat

M Maxime J van Oort