Advances in the diagnosis and treatment of capillary malformation-arteriovenous malformation syndrome

Zhonghua Yu Fang Yi Xue Za Zhi. 2026 Oct 6;60(10):1704-1710. doi: 10.3760/cma.j.cn112150-20251016-00993.ABSTRACTCapillary malformation-arteriovenous malformation (CM-AVM) syndrome is a rare hereditary vascular disorder encountered in clinical practice. Owing to its complex pathogenesis, heterogeneou

Y Y Y Jia

Apolipoprotein E4 and immune dysfunction in Alzheimer's disease: mechanisms and therapeutic implications

Trends Neurosci. 2026 Oct 19:S0166-2236(26)00191-8. doi: 10.1016/j.tins.2026.09.009. Online ahead of print.ABSTRACTEmerging evidence suggests that apolipoprotein E4 (APOE4) functions as an organizer of brain-periphery immune crosstalk, coupling maladaptive microglial states with peripheral immune re

H Hao Shi

High Lipoprotein(a) Is a Predictor of Adverse Events and Heart Failure in Patients With Acute Myocardial Infarction

Circ J. 2026 Oct 16. doi: 10.1253/circj.CJ-26-0268. Online ahead of print.ABSTRACTBACKGROUND: Lipoprotein(a) (Lp(a)) is a well-established risk factor for atherosclerotic cardiovascular disease, but its prognostic role after acute myocardial infarction (AMI) remains unclear. This study investigated

Y Yang Wang

Drug-Specific Associations of Angiotensin Receptor Blockers With Parkinson's Disease Risk in a Multicenter Electronic Health Record Cohort

Fundam Clin Pharmacol. 2026 Nov;40(6):e70113. doi: 10.1111/fcp.70113.ABSTRACTBACKGROUND: Angiotensin receptor blockers (ARBs) have demonstrated neuroprotective effects in preclinical models of Parkinson's disease (PD), but individual ARBs differ in pharmacological properties that may influence their

K Kyle Tran

Impact of Physical Activity on Cardiovascular Outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease

J Gastroenterol Hepatol. 2026 Oct 18. doi: 10.1111/jgh.70826. Online ahead of print.ABSTRACTAIM: We investigated whether accelerometer-assessed moderate-to-vigorous physical activity (MVPA) is associated with cardiovascular mortality among individuals with metabolic dysfunction-associated steatotic

D Donghee Kim

Long-term Nlrp3 gain-of-function mutation promotes cardiac dysfunction independent of inflammasome in mice

J Immunol. 2026 Oct 1;215(10):vkag257. doi: 10.1093/jimmun/vkag257.ABSTRACTCryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by gain-of-function mutations in human nucleotide-binding domain, leucine-rich repeat-containing protein 3 (NLRP3), which lead to constitutiv

M Mie Kurata

A novel framework for identifying cellular signature LncRNAs and their functional coregulatory networks with prognostic implications at single-cell resolution

J Adv Res. 2026 Oct 18:S2090-1232(26)00824-6. doi: 10.1016/j.jare.2026.10.034. Online ahead of print.ABSTRACTINTRODUCTION: Long non-coding RNAs have been implicated in crucial roles in developing malignant tumors. However, comprehensive analyses of lncRNA within the tumor microenvironment, particula

J Jing Bai

Aerobic exercise ameliorates cardiac function in HFpEF mice by suppressing ALCAT1, neuroinflammation and oxidative stress in the paraventricular nucleus and nucleus tractus solitarius

Brain Behav Immun. 2026 Oct 18:107078. doi: 10.1016/j.bbi.2026.107078. Online ahead of print.ABSTRACTBACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is commonly accompanied by sympathetic overactivation, contributing to poor patient prognosis. The paraventricular nucleus (PVN) and

Y Yifang Zhao

Trends in cardiovascular disease and risk factors between 2004 and 2021: Findings from the U.S. Millennium Cohort Study

Prev Med. 2026 Oct 18:108687. doi: 10.1016/j.ypmed.2026.108687. Online ahead of print.ABSTRACTOBJECTIVE: Cardiovascular disease (CVD) is a leading cause of death in the United States (U.S.). Military veterans have notably high prevalences of CVD. The aim was to report the prevalence of self-reported

C Claire A Kolaja

Familial glycerol kinase deficiency uncovered by triglyceride-lipemic index discordance

Clin Chim Acta. 2026 Oct 18:122914. doi: 10.1016/j.cca.2026.122914. Online ahead of print.ABSTRACTBACKGROUND: Pseudohypertriglyceridemia caused by elevated free glycerol is an uncommon analytical interference that may lead to misdiagnosis and unnecessary treatment. Because most routine enzymatic tri

C Carla Fernández-Prendes

Menstrual Health in Children, Adolescents, and Young Adults with Cardiac Disease: An Underrecognized Component of Heart Failure, Mechanical Circulatory Support, and Transplant Care

J Heart Lung Transplant. 2026 Oct 18:S1053-2498(26)02145-5. doi: 10.1016/j.healun.2026.10.011. Online ahead of print.ABSTRACTBACKGROUND: Menstrual abnormalities, including heavy menstrual bleeding, amenorrhea, and dysmenorrhea, are frequently encountered among children, adolescents, and young adults

H HaEun Jazmin Kim

Network Analysis of Chronic Disease Diagnosis Co-documentation in Insurance Claims Among Older Arkansans

Ann Epidemiol. 2026 Oct 18:110310. doi: 10.1016/j.annepidem.2026.110310. Online ahead of print.ABSTRACTBACKGROUND: Multimorbidity among older adults presents growing clinical and economic challenges, particularly in medically underserved states such as Arkansas. However, it remains unclear whether c

M Mohsen Bazargan

Feature selection and dimensionality reduction in multi-omics

Genome. 2026 Oct 18. doi: 10.1139/gen-2026-0094. Online ahead of print.ABSTRACTHigh-throughput multi-omics technologies generate high-dimensional, heterogeneous and noisy datasets, making robust biomarker discovery and disease modelling challenging. This review critically examines dimensionality red

S Sweta Rai

Compound Astragalus Oral Liquid Attenuates Ventricular Remodeling in Heart Failure After Myocardial Infarction via the AMPK/TGF-β/Smad Signaling Pathway

Biomed Res Int. 2026;2026(1):e1276968. doi: 10.1155/bmri/1276968.ABSTRACTBACKGROUND: Ventricular remodeling following acute myocardial infarction (AMI) is a critical cause of heart failure (HF). Compound Astragalus Oral Liquid (CAOL) is a traditional Chinese medicine formulation with anti-inflammato

Z Zhijun Yang

Serum Glycoprotein VI in Acute Pulmonary Embolism: Association With Radiological Thrombus Burden and Clinical Risk Indicators

Can Respir J. 2026;2026(1):e9286221. doi: 10.1155/carj/9286221.ABSTRACTBACKGROUND: Pulmonary embolism (PE) is a life-threatening condition requiring rapid diagnosis and accurate risk stratification. Biomarkers reflecting thromboinflammatory processes may improve early clinical assessment. Glycoprote

M Mert Metin İnan

Popliteal artery entrapment syndrome. Current concepts, dilemmas, and challenges

Br Med Bull. 2026 Oct 5;160(1):ldag034. doi: 10.1093/bmb/ldag034.ABSTRACTINTRODUCTION: Popliteal artery entrapment syndrome (PAES) results from extrinsic compression of the popliteal artery as it passes through the popliteal fossa due to congenital musculotendinous anomalies or acquired muscle hyper

L Laura Calsina-Juscafresa

Acinar-Derived Organoids Reveal Stage-Specific Control of Acinar Plasticity

Adv Sci (Weinh). 2026 Oct 18:e78350. doi: 10.1002/advs.78350. Online ahead of print.ABSTRACTAdult pancreatic acinar cells undergo ordered metaplastic conversion during injury and tumor initiation. Whether individual cells retain redifferentiation capacity after metaplastic expansion, and what signal

Y Yongfei Hou

Use of vaginal estrogens in urogynecology: current evidence, controversies and clinical applications

Curr Opin Obstet Gynecol. 2026 Oct 20. doi: 10.1097/GCO.0000000000001157. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Genitourinary syndrome of menopause (GSM) is a prevalent yet underrecognized condition in postmenopausal women, characterized by progressive vulvovaginal and lower urinary tract

P Priyanka Singh

Symptom-Driven Prediction of Chronic Multimorbidity with a Macro-Micro Heterogeneous Graph Neural Network

Adv Sci (Weinh). 2026 Oct 18:e78348. doi: 10.1002/advs.78348. Online ahead of print.ABSTRACTThe growing prevalence and complexity of multimorbidity pose significant challenges to healthcare systems worldwide. Here, we developed a heterogeneous graph neural network framework for multilabel multimorbi

Y Yiheng Ye

Magnetic resonance imaging vs computed tomography for baseline imaging evaluation in acute basilar artery occlusion

J Neurol. 2026 Oct 18;273(11):670. doi: 10.1007/s00415-026-14159-4.ABSTRACTBACKGROUND: The optimal imaging modality, magnetic resonance imaging (MRI) or computed tomography (CT), for identifying good treatment candidates among patients with acute basilar-artery occlusion (BAO) remains unclear.METHOD

F Feiyang Gao

β3-Adrenergic Receptor Agonism Reduces Right Ventricular Systolic Pressure in a Preclinical Model of Heart Failure With Preserved Ejection Fraction-Associated Pulmonary Hypertension

J Cardiovasc Pharmacol Ther. 2026 Jan-Dec;31:10742484261495417. doi: 10.1177/10742484261495417. Epub 2026 Oct 18.ABSTRACTPurposePulmonary hypertension (PH) commonly complicates heart failure with preserved ejection fraction (HFpEF), driving morbidity and mortality, yet no therapies exist for HFpEF-P

C Christelle Lteif

Endothelial dysfunction and long-term survival in cardiovascular-kidney-metabolic syndrome stages 0-3: An EASIX-based national cohort study

Sci Prog. 2026 Oct-Dec;109(4):368504261499186. doi: 10.1177/00368504261499186. Epub 2026 Oct 18.ABSTRACTObjectiveTo assess the association of the endothelial activation and stress index (EASIX) with all-cause and cardiovascular mortality in adults at cardiovascular-kidney-metabolic (CKM) syndrome st

A Asiya Abudesimu

How relationships with exercise change: A qualitative study on the influences of exercise decision-making with systemic lupus erythematosus and cardiovascular disease

Lupus. 2026 Oct 18:9612033261499215. doi: 10.1177/09612033261499215. Online ahead of print.ABSTRACTBackground: Greater than 50% of individuals with systemic lupus erythematosus (SLE) will develop cardiovascular disease (CVD). Moderate-intensity aerobic exercise significantly reduces CVD risk, morbid

M Melissa J Frederick

Cardiology Support Utilization Patterns and Associated Barriers Across Northwestern Ontario

Healthc Manage Forum. 2026 Oct 18:8404704261492943. doi: 10.1177/08404704261492943. Online ahead of print.ABSTRACTThe Thunder Bay Regional Health Sciences Centre On-Call Cardiology Support Service serves a geographically vast region across Northwestern Ontario where cardiovascular disease is a major

J Jamal Al-Atawneh