Myocardial Strain Evaluation from Cardiovascular MRI and CT: Physiological Principles and Clinical Perspectives

Br J Radiol. 2026 Sep 18:tqag192. doi: 10.1093/bjr/tqag192. Online ahead of print.ABSTRACTGlobal markers of myocardial function are limited in the information they provide, warranting the need for local markers that are sensitive and specific to myocardial physiology. Myocardial deformation, quantif

T T M Hussein

Alpha-Amino Oleic Acid as Anticalcification Agent for Porcine Bioprosthetic Heart Valves: A Narrative Review

Interdiscip Cardiovasc Thorac Surg. 2026 Sep 18:ivag246. doi: 10.1093/icvts/ivag246. Online ahead of print.ABSTRACTOBJECTIVE: Calcification remains the principal mechanism limiting the durability of bioprosthetic heart valves. Alpha-amino oleic acid (AOA) was developed as an anticalcification treatm

L Lennart Vanglabeke

Molecular and cellular crosstalk between atherosclerosis and cancer: Mechanistic insights and therapeutic opportunities

Cell Mol Biol (Noisy-le-grand). 2026 May 31;72(5):38-46. doi: 10.14715/cmb/2026.72.5.6.ABSTRACTAtherosclerosis and cancer are among the leading causes of morbidity and mortality worldwide and are increasingly recognized as biologically interconnected diseases rather than independent pathological con

A Alexander V Blagov

Association of SII, LAR, and D-Dimer with In-Hospital Adverse Outcomes in Acute Pulmonary Embolism

Clin Appl Thromb Hemost. 2026 Jan-Dec;32:10760296261488578. doi: 10.1177/10760296261488578. Epub 2026 Sep 18.ABSTRACTObjectivesTo investigate the prognostic value of the systemic immune-inflammation index (SII), lactate-to-albumin ratio (LAR), and D-dimer for in-hospital adverse outcomes in patients

Z Zixuan Chen

Gut microbiota-mediated dietary lignans metabolism drives accumulation of N,N-dimethylsphingosine and sensitizes triple-negative breast cancer to paclitaxel

Food Funct. 2026 Sep 18. doi: 10.1039/d6fo01787h. Online ahead of print.ABSTRACTFor triple-negative breast cancer (TNBC), which lacks specific therapeutic targets, paclitaxel (PTX) chemotherapy remains the first-line clinical treatment. However, the widespread issue of treatment resistance severely

J Jianyu Wang

Primary Cardiac Undifferentiated Pleomorphic Sarcoma Presenting as Obstructive Shock: Multimodality Imaging Guides Management

JACC Case Rep. 2026 Sep 18:110393. doi: 10.1016/j.jaccas.2026.110393. Online ahead of print.ABSTRACTBACKGROUND: Primary cardiac undifferentiated pleomorphic sarcoma is a rare and highly aggressive malignancy. Obstructive shock is an uncommon presentation requiring prompt diagnosis and management.CAS

D Diego Davila Flores

The impact of temporal trends in stroke event rates and 30-day case fatality on trends in stroke mortality: an international comparative study

Int J Epidemiol. 2026 Aug 18;55(5):dyag157. doi: 10.1093/ije/dyag157.ABSTRACTBACKGROUND: Stroke mortality rates have declined in recent decades; however, data on contemporary drivers of this trend are limited. This study compared the contribution of trends in stroke event rates and 30-day case fatal

L Lee Nedkoff

Association between caregiving status and cognitive function as well as activities of daily living among community-dwelling older adults with Alzheimer's disease: A cross-sectional study

J Alzheimers Dis. 2026 Sep 18:13872877261488017. doi: 10.1177/13872877261488017. Online ahead of print.ABSTRACTBackgroundAlzheimer's disease is associated with progressive cognitive decline and impaired activities of daily living. Professional institutional care and family home care are common long-

R Ruzhao Li

Impact of Left Internal Mammary Artery-to-Left Anterior Descending Artery Anastomotic Location on Graft Patency: A Secondary Analysis of the PATENCY Trial Data Set

J Am Heart Assoc. 2026 Sep 18:e051333. doi: 10.1161/JAHA.126.051333. Online ahead of print.ABSTRACTBACKGROUND: The impact of the left internal mammary artery (LIMA)-to-left anterior descending artery (LAD) anastomotic location on graft patency remains uncertain.METHODS: This study included 1597 pati

C Chunyuan Wang

Clinical Prediction Models in Cardiovascular Disease: Foundations, Clinical Applications and Future Directions

J Am Heart Assoc. 2026 Sep 18:e053665. doi: 10.1161/JAHA.126.053665. Online ahead of print.ABSTRACTClinical prediction models have progressed from traditional risk scores derived from epidemiological cohorts into sophisticated systems capable of integrating multimodal data, electronic health records

B Bingyi Wang

Multivariate Machine Learning Model for Long-Term Risk Prediction of Acute Coronary Syndrome in Patients With Heart Failure With Preserved Ejection Fraction and Obstructive Sleep Apnea

J Am Heart Assoc. 2026 Sep 18:e050956. doi: 10.1161/JAHA.126.050956. Online ahead of print.ABSTRACTBACKGROUND: Heart failure with preserved ejection fraction is a heterogeneous syndrome, and comorbid obstructive sleep apnea further increases the risk of acute coronary syndrome. However, effective to

Y YiJun Wang

Trends in Incidence of Atrial Fibrillation-Related Stroke: The Norwegian AFNOR Study

J Am Heart Assoc. 2026 Sep 18:e049696. doi: 10.1161/JAHA.126.049696. Online ahead of print.ABSTRACTBACKGROUND: The increasing prevalence of atrial fibrillation (AF), along with changes in cardiovascular risk factors, AF detection and oral anticoagulant use, may have altered the epidemiology of AF-re

M Mariam Anjum

Comparative Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients With Heart Failure and Chronic Kidney Disease

J Am Heart Assoc. 2026 Sep 18:e051598. doi: 10.1161/JAHA.126.051598. Online ahead of print.ABSTRACTBACKGROUND: Evidence comparing intermediate-term outcomes of transcatheter aortic valve implantation (TAVI) versus surgical aortic valve replacement (SAVR) in patients with concomitant heart failure an

I Ibrahim Mortada

Choroidal Vascular Remodeling After Loading Injections of Faricimab in Diabetic Macular Edema

Transl Vis Sci Technol. 2026 Sep 1;15(9):8. doi: 10.1167/tvst.15.9.8.ABSTRACTPURPOSE: We evaluated choroidal structural changes in patients with diabetic macular edema (DME) after a loading phase of 3 monthly intravitreal faricimab injections.METHODS: This retrospective cohort study included treatme

J Jounghan Kim

Ultra-Widefield OCTA Mapping of Epiretinal Macrophage-Like Cells in Patients With Retinal Vein Occlusion

Transl Vis Sci Technol. 2026 Sep 1;15(9):9. doi: 10.1167/tvst.15.9.9.ABSTRACTPURPOSE: To characterize the ultra-widefield distribution and morphology of epiretinal macrophage-like cells (eMLCs) in retinal vein occlusion (RVO) and assess their associations with retinal ischemia and macular edema.METH

H Hongzhan Lin

Mitral Valve Lithotripsy With SmartCrack Balloon for Severe Calcified Mitral Stenosis: First-in-Human Experience

J Am Heart Assoc. 2026 Sep 18:e050755. doi: 10.1161/JAHA.126.050755. Online ahead of print.ABSTRACTBACKGROUND: Mitral stenosis due to mitral annular calcification and calcific rheumatic heart disease (CRHD) remains challenging to treat. This first-in-human study evaluated the safety and feasibility

K Kent Chak-Yu So

Multicenter Study of the Electrical Characteristics and Short-Term Outcomes of the Aveir VR Leadless Pacemaker

J Am Heart Assoc. 2026 Sep 18:e050579. doi: 10.1161/JAHA.126.050579. Online ahead of print.ABSTRACTBACKGROUND: The Aveir leadless pacemaker uses an active fixation method, enabling real-time monitoring of electrical parameters during implantation. However, comprehensive studies on the electrical par

J Jian-du Yang

Do Androgens and Sex Hormone-Binding Globulin Mediate Sex Differences in the Risk of Stroke and Myocardial Infarction? The KORA Study

J Am Heart Assoc. 2026 Sep 18:e047531. doi: 10.1161/JAHA.125.047531. Online ahead of print.ABSTRACTBACKGROUND: Sex differences in cardiovascular disease are well established, but the role of androgens and sex hormone-binding globulin (SHBG) remains unclear. We investigated whether these hormones and

H Hamidreza Raeisi-Dehkordi

Cardiometabolic and Inflammatory Predictors of Life-Threatening Ventricular Arrhythmias in Adults Without Structural Heart Diseases

J Am Heart Assoc. 2026 Sep 18:e050176. doi: 10.1161/JAHA.126.050176. Online ahead of print.ABSTRACTBACKGROUND: Life-threatening ventricular arrhythmias (LTVAs) can occur in individuals without apparent structural heart disease, yet the cardiometabolic and inflammatory determinants remain unclear. We

H Hong-Da Zhang

Real-World Effectiveness of Evolocumab in Reducing Major Adverse Cardiovascular Events: A Cohort Study

J Am Heart Assoc. 2026 Sep 18:e049323. doi: 10.1161/JAHA.126.049323. Online ahead of print.ABSTRACTBACKGROUND: Evolocumab reduces major adverse cardiovascular events in randomized trials, but evidence of its effectiveness in real-world clinical practice remains limited.METHODS: US adults with athero

R Ran Jin

Interactions Between Health Inequalities on the Management and Outcomes of Thoracic Aortic Disease in England: A National Cohort Study

J Am Heart Assoc. 2026 Sep 18:e047851. doi: 10.1161/JAHA.125.047851. Online ahead of print.ABSTRACTBACKGROUND: The aim of this study was to evaluate the intersectionality between measured causes of health inequality and clinical factors that influence treatment decisions and regional variations in c

R Riccardo Giuseppe Abbasciano

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

J Am Heart Assoc. 2026 Sep 18:e045052. doi: 10.1161/JAHA.125.045052. Online ahead of print.ABSTRACTBACKGROUND: Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAce

Y Yanxing Fang

Association Between Rest-Activity Rhythm and Cardiovascular Disease, Cardiovascular Mortality, and All-Cause Mortality: A Systematic Review and Meta-Analysis

J Am Heart Assoc. 2026 Sep 18:e048656. doi: 10.1161/JAHA.125.048656. Online ahead of print.ABSTRACTBACKGROUND: Disruption in rest-activity rhythm (RAR) is an emerging risk factor for cardiovascular disease (CVD) and mortality, but the strength of evidence is unclear. Therefore, we conducted a system

F Fengshuo Chang

Stillbirth as a Risk Marker for Postpartum Readmission for Cardiovascular Disease: A Population-Based Retrospective Cohort Study

J Am Heart Assoc. 2026 Sep 18:e051951. doi: 10.1161/JAHA.126.051951. Online ahead of print.ABSTRACTBACKGROUND: Cardiovascular disease (CVD) remains a leading cause of pregnancy-related morbidity and death in the early postpartum period. Stillbirth is associated with elevated long-term CVD risk. Howe

A Anushka Pande