Bioinformatics. 2026 Jan 22:btag032. doi: 10.1093/bioinformatics/btag032. Online ahead of print.ABSTRACTMOTIVATION: Genome-wide association studies (GWAS) at biobank scale are computationally intensive, especially for admixed populations requiring robust statistical models. SAIGE is a widely used me
Cardiooncology. 2026 Jan 22;12(1):9. doi: 10.1186/s40959-025-00417-3.ABSTRACTBACKGROUND: HIV, cancer, and their respective treatments are independently associated with cardiovascular risk, but limited data exist on the intersection of these conditions. The purpose of this study was to gain insights
Hum Genomics. 2026 Jan 22. doi: 10.1186/s40246-025-00882-y. Online ahead of print.ABSTRACTThe interaction between the genome and the exposome is increasingly recognized as central to human health and disease. While exposome research has generally focused on adverse exposures such as pollutants and t
Diabetol Metab Syndr. 2026 Jan 22. doi: 10.1186/s13098-025-02039-2. Online ahead of print.ABSTRACTBACKGROUND: The impact of discordance between remnant cholesterol (RC) and low-density lipoprotein cholesterol (LDL-c) on diabetes, diabetic kidney disease (DKD), diabetic retinopathy (DR) and cardiovas
Cardiovasc Diabetol. 2026 Jan 22. doi: 10.1186/s12933-025-03073-0. Online ahead of print.ABSTRACTBACKGROUND: The COLCOT trial showed that patients with diabetes may benefit from low-dose colchicine, suggesting a potential interplay between insulin resistance (IR) and inflammation. Whether their comb
BMC Med. 2026 Jan 22. doi: 10.1186/s12916-026-04649-7. Online ahead of print.ABSTRACTBACKGROUND: The anatomical and pathophysiological characteristics of coronary artery disease vary between the sexes. This study investigated the impact of sex on outcomes in patients with de novo coronary artery les
BMC Geriatr. 2026 Jan 23. doi: 10.1186/s12877-026-06972-3. Online ahead of print.ABSTRACTBACKGROUND: DOACs are increasingly prescribed for atrial fibrillation and venous thromboembolism due to their ease of use and lack of monitoring requirements. Prescribing DOACs to frail older patients remains ch
Heart Fail Rev. 2026 Jan 23;31(1):21. doi: 10.1007/s10741-025-10592-1.ABSTRACTCongestion represents the principal clinical manifestation and hemodynamic hallmark of heart failure (HF), reflecting elevated cardiac filling pressures. It remains the leading cause of HF hospitalization and is consistent
J Robot Surg. 2026 Jan 23;20(1):203. doi: 10.1007/s11701-026-03164-4.ABSTRACTWe report the early outcomes of subcostal robot-assisted thoracic surgery (subRATS) for non-small cell lung cancer (NSCLC). We conducted a prospective, single-arm cohort study at Seoul National University Bundang Hospital b
Nat Rev Cardiol. 2026 Jan 22. doi: 10.1038/s41569-026-01253-3. Online ahead of print.ABSTRACTChronic inflammation has long been recognized as a major risk factor for and a causal contributor to cardiovascular disease (CVD). However, advances in omics technologies and deepening insights into CVD path
Eur J Clin Pharmacol. 2026 Jan 23;82(2):60. doi: 10.1007/s00228-025-03970-z.ABSTRACTBACKGROUND: Patients undergoing transcatheter aortic valve replacement (TAVR) often require anticoagulation therapy due to various comorbidities. However, the decision to continue anticoagulation therapy during the T
Apoptosis. 2026 Jan 23;31(2):53. doi: 10.1007/s10495-026-02268-4.ABSTRACTThe cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway serves as a core signaling axis for sensing cytosolic DNA and activating innate immunity. By recognizing abnormal DNA released from pathogens or
Sci Rep. 2026 Jan 22. doi: 10.1038/s41598-025-88253-4. Online ahead of print.ABSTRACTSmoking is a major cause of cardiovascular diseases, including myocardial infarction (MI) and stroke. However, the role of age at smoking initiation in cardiovascular risk has not been fully established. We selected
Signal Transduct Target Ther. 2026 Jan 23;11(1):27. doi: 10.1038/s41392-025-02531-1.ABSTRACTAt high altitudes, which typically exceed 2500 m, approximately 80 million people reside permanently, with over a million visitors annually. The primary effect of high altitude is hypobaric hypoxia, which lea
Expert Rev Med Devices. 2026 Jan 22. doi: 10.1080/17434440.2026.2621892. Online ahead of print.ABSTRACTINTRODUCTION: Transcatheter aortic valve replacement (TAVR) has transformed treatment of severe aortic stenosis, offering a less invasive alternative to surgery. Despite advances, stroke remains a
Heart Lung Circ. 2026 Jan 21:S1443-9506(25)01619-1. doi: 10.1016/j.hlc.2025.08.025. Online ahead of print.ABSTRACTAIM: Whether aortic valve sparing (valve sparing root replacement [VSRR]) and Bentall surgery differently affect myocardial dysfunction is not clear. This study aimed to clarify whether
BMJ Open. 2026 Jan 22;16(1):e106485. doi: 10.1136/bmjopen-2025-106485.ABSTRACTOBJECTIVE: To examine how patients and family members decide whether to accept a highly invasive intervention (aortic valve replacement (AVR)) when their condition (aortic stenosis (AS)) is asymptomatic and its course unce
BMJ Open. 2026 Jan 22;16(1):e102831. doi: 10.1136/bmjopen-2025-102831.ABSTRACTOBJECTIVES: This study aimed to investigate the impacts of chronic diseases such as hypertension, dyslipidaemia and diabetes on personal and household income among ageing Chinese adults. The primary hypothesis was that the
BMJ Open. 2026 Jan 22;16(1):e110108. doi: 10.1136/bmjopen-2025-110108.ABSTRACTBACKGROUND: Night shift work is well known to cause health disruption in the short and long term. Among healthcare workers, sleep deprivation is a common concern with many nurses reporting sleep of <6 hour per 24-hour peri
BMJ Open Respir Res. 2026 Jan 22;13(1):e003743. doi: 10.1136/bmjresp-2025-003743.ABSTRACTBACKGROUND: The prognostic significance of systemic inflammation in pulmonary embolism (PE) remains unclear. This study aimed to evaluate the predictive value of a novel Inflammatory Burden Index (IBI) for long-
BMJ Case Rep. 2026 Jan 22;19(1):e269990. doi: 10.1136/bcr-2025-269990.ABSTRACTSturge-Weber syndrome (SWS) and Klippel-Trenaunay syndrome (KTS) are rare vascular malformation disorders characterised by distinct clinical features but overlapping pathogenic mechanisms, involving somatic mosaic mutation
Eur Heart J. 2026 Jan 23:ehaf1059. doi: 10.1093/eurheartj/ehaf1059. Online ahead of print.ABSTRACTIschaemic heart disease shows important differences between men and women, requiring an understanding of sex and gender dissimilarities to improve outcomes. This Scientific Statement provides an updated
RMD Open. 2026 Jan 22;12(1):e006085. doi: 10.1136/rmdopen-2025-006085.ABSTRACTOBJECTIVE: The aim of this study was to investigate the relationship between antineutrophil cytoplasmic antibodies (ANCA) specificity and the risk of major adverse cardiovascular events (MACE) in patients with ANCA-associa
RMD Open. 2026 Jan 22;12(1):e005512. doi: 10.1136/rmdopen-2025-005512.ABSTRACTOBJECTIVES: To assess the incidence and risk factors for arrhythmias in patients with psoriatic arthritis (PsA).METHODS: We performed a cohort analysis of patients followed prospectively from 1994 to 2024. Participants wer
