Comparative Cardiovascular Safety of Prescription Amphetamine and Methylphenidate Initiation Among Older Adult Medicare Beneficiaries

Pharmacoepidemiol Drug Saf. 2026 Apr;35(4):e70381. doi: 10.1002/pds.70381.ABSTRACTBACKGROUND: Prescription stimulant use among the United States' (US) older adult population is increasing, yet little is known about the cardiovascular safety profiles of the two major prescription stimulant classes, m

N Noah Smith

Aortic Calcification Severity Predicts Unfavorable Anatomy and Adverse Outcomes in Type B Aortic Dissection

J Endovasc Ther. 2026 Apr 20:15266028261439546. doi: 10.1177/15266028261439546. Online ahead of print.ABSTRACTOBJECTIVE: Aortic calcification (AC) is increasingly recognized as a marker associated with cardiovascular disease, but its role in acute aortic syndromes such as type B aortic dissection (T

L Long Cao

No antithrombotic therapy versus single antiplatelet therapy after percutaneous left atrial appendage closure in non-valvular atrial fibrillation: rationale and design of the multicentre, randomised, non-inferiority NAPT-LAAC trial

EuroIntervention. 2026 Apr 20;22(8):e455-e462. doi: 10.4244/EIJ-D-25-01307.ABSTRACTThe current standard regimen for antithrombotic therapy after percutaneous left atrial appendage closure (LAAC) in patients with non-valvular atrial fibrillation (NVAF) recommends long-term use of antiplatelet agents.

T Toshiaki Otsuka

Targeting the Pathological Microenvironment in Diabetic Foot Ulcers: Advances in Drug Delivery Systems for Improved Healing

J Biomed Mater Res B Appl Biomater. 2026 Apr;114(4):e70079. doi: 10.1002/jbm.b.70079.ABSTRACTDiabetic foot ulcers (DFUs) are among the most severe and disabling complications of diabetes, characterized by delayed healing, frequent recurrence, and a high risk of infection and amputation. Their pathog

W Wanqing Dai

Pharmacodynamic Effects of Salvia miltiorrhiza-Dalbergia Odorifera in the Treatment of Ischemic Stroke Based on the Mixture Design

Rejuvenation Res. 2026 Apr 19:15491684261442837. doi: 10.1177/15491684261442837. Online ahead of print.ABSTRACTSalvia miltiorrhiza(SM)-Dalbergia odorifera (DO) is a commonly used circulating blood and transforming stasis drug pair for the treatment of cardiovascular and cerebrovascular diseases, but

Z Ziheng Ding

Pseudoaneurysm of the Left Renal Segmental Artery With Delayed Detection After Blunt Trauma

Am J Case Rep. 2026 Apr 20;27:e951740. doi: 10.12659/AJCR.951740.ABSTRACTBACKGROUND Renal pseudoaneurysms can occur following penetrating renal trauma, renal surgery, or renal biopsy, and are a cause of delayed bleeding. However, cases occurring after blunt trauma are rare, and pseudoaneurysms may b

A Atsuto Kobayashi

From Co-Design to Quality Improvement: Using the Double Diamond Framework to Develop Primary Care Redesign Priorities for Hypertension Care

Health Expect. 2026 Apr;29(2):e70673. doi: 10.1111/hex.70673.ABSTRACTINTRODUCTION: Despite evidence supporting clinic-community linked hypertension interventions for socially disadvantaged populations, sustaining these interventions in real-world primary care has been challenging. The objective of t

S Sonal J Patil

The Role of β-Blockers in the Evolving Treatment Landscape of Resistant Hypertension

Drugs. 2026 Apr 20. doi: 10.1007/s40265-026-02319-9. Online ahead of print.ABSTRACTResistant hypertension (RHTN) is estimated to affect approximately 15% of all patients with hypertension, although its reported prevalence varies according to the blood pressure (BP) thresholds used for diagnosis, the

S Stefano Masi

Live-cell imaging reveals decreased cAMP in a PFE-associated c.1050-3C>G PTH1R cell model

J Mol Med (Berl). 2026 Apr 20;104(1):66. doi: 10.1007/s00109-026-02668-8.ABSTRACTPrimary failure of eruption (PFE) is a rare autosomal disorder provoked by heterozygous mutations in the parathyroid hormone receptor 1 (PTH1R) gene. PTH1R is a G protein-coupled receptor (GPCR) which regulates intracel

K K Marnet

The neutrophil-to-lymphocyte ratio: a psychoneuroimmunological nexus linking depression and cardiovascular comorbidity

No abstractEur Arch Psychiatry Clin Neurosci. 2026 Apr 20. doi: 10.1007/s00406-026-02241-x. Online ahead of print.NO ABSTRACTPMID:42002608 | DOI:10.1007/s00406-026-02241-x

C Chengyu Du

End-to-end pipeline for automated heart failure diagnosis with clinical notes using SNOMED-CT

Sci Rep. 2026 Apr 19;16(1):12751. doi: 10.1038/s41598-026-48771-1.ABSTRACTDiagnosis of heart failure is complex but crucial for patient outcomes and often hindered by the untapped potential of unstructured clinical notes. We introduce a novel end-to-end pipeline for heart failure diagnosis, leveragi

F Fu-Sung Kim-Benjamin Tang

Generation of a human-induced pluripotent stem cell line from a retinitis pigmentosa patient carrying biallelic mutations in EYS gene

Hum Cell. 2026 Apr 19;39(5):68. doi: 10.1007/s13577-026-01383-3.ABSTRACTRetinitis pigmentosa (RP) is a hereditary retinal disorder characterized by progressive degeneration of photoreceptor cells in the retina, leading to gradual vision loss. Symptoms of RP typically begin with night blindness and p

J Jueun Kim

The association of night shift work with the risk of acute ischemic cerebrovascular syndrome: a longitudinal study of 204,261 UK Biobank participants

J Neurol. 2026 Apr 19;273(5):280. doi: 10.1007/s00415-026-13827-9.ABSTRACTBACKGROUND: Shift work is highly prevalent globally, yet evidence linking it to ischemic cerebrovascular disease remains inconsistent. Existing studies are limited by unsystematic quantification of night shift exposure and out

Y Yanhao Huang

Therapeutic Remodeling of the Gut Microbiome as a Strategy to Restore Immune Tolerance in Autoimmunity

Microbiologyopen. 2026 Apr;15(2):e70294. doi: 10.1002/mbo3.70294.ABSTRACTAutoimmune diseases happen when the immune system, which is supposed to defend the body from infections and other harmful things, starts to attack the body's own cells by mistake. In the last few years, they seem to be getting

B Behshad Boroumand

Predictors and Outcomes of Pulmonary Embolism After Coronary Artery Bypass Grafting

Angiology. 2026 Apr 19:33197261436916. doi: 10.1177/00033197261436916. Online ahead of print.ABSTRACTPulmonary embolism (PE) can be a life-threatening complication following coronary artery bypass grafting (CABG). However, the impact of PE on short-term outcomes such as readmission and mortality rem

A Ankit Agrawal

Carotid Ultrasound for Predicting Vascular Cognitive Impairment in Cardiovascular Patients: A Retrospective Study

Angiology. 2026 Apr 19:33197261435395. doi: 10.1177/00033197261435395. Online ahead of print.ABSTRACTVascular cognitive impairment (VCI) affects 20% to 40% of cardiovascular patients, yet early identification remains challenging. This retrospective study evaluated the predictive value of carotid ult

X Xueyan Lv

T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age-Related Diseases

Immunol Rev. 2026 May;339(1):e70125. doi: 10.1111/imr.70125.ABSTRACTCardiovascular diseases (CVD) are shaped by a complex interplay with immune mechanisms. In particular, the distinct roles of antigen-specific T cell mechanisms are emerging as critical determinants across a broad spectrum of conditi

L Leon Richter

Genetic analysis and clinical phenotype of pulmonary arterial hypertension in an Algerian population

Ann Saudi Med. 2026 Mar-Apr;46(2):111-120. doi: 10.5144/0256-4947.2026.111. Epub 2026 Apr 16.ABSTRACTBACKGROUND: Pulmonary arterial hypertension (PAH) involves progressive obstruction of small pulmonary vessels due to vascular remodeling. Although the genetic architecture of PAH is increasingly unde

A Amel Wafa Berkane

Associations of Neprilysin and Its Coding Gene Variation With Hypertension in Chinese Adults

J Clin Hypertens (Greenwich). 2026 Apr;28(4):e70260. doi: 10.1111/jch.70260.ABSTRACTNeprilysin (NEP) degrades several vasoactive peptides and may contribute to blood pressure maintenance. This study aims to examine the associations between serum NEP levels and variants at its coding gene and hyperte

J Junting Hu

Divergent Trends in Stroke Subtype Mortality Attributable to High Systolic Blood Pressure in China, 1990 to 2021: An Age-Period-Cohort Analysis and Projection

Med Sci Monit. 2026 Apr 19;32:e951794. doi: 10.12659/MSM.951794.ABSTRACTBACKGROUND High systolic blood pressure (HSBP) is a major contributor to stroke mortality in China. This study analyzed trends in HSBP-attributable stroke mortality from 1990 to 2021 to elucidate the effects of age, period, and

Y Yaoyao Li

Polypharmacy and Drug-Drug Interactions in Long-Term Care Facilities residents: findings from the Italian Prescription Day Project

J Gerontol A Biol Sci Med Sci. 2026 Apr 17:glag104. doi: 10.1093/gerona/glag104. Online ahead of print.ABSTRACTBACKGROUND: Medication prescribing in Long-Term Care Facilities (LTCFs) is characterised by widespread polypharmacy and frequent exposure to potentially clinically relevant drug-drug intera

A Alba Malara

International consensus on adolescent metabolic health: prevention of obesity and type 2 diabetes

No abstractDiabetol Metab Syndr. 2026 Apr 18. doi: 10.1186/s13098-026-02142-y. Online ahead of print.NO ABSTRACTPMID:42001194 | DOI:10.1186/s13098-026-02142-y

I Inass Shaltout

MRI-based clinical-radiologic model to predict the efficacy and prognosis of interventional with systemic therapy in advanced hepatocellular carcinoma: a multicenter study

No abstractJ Transl Med. 2026 Apr 18. doi: 10.1186/s12967-026-08166-2. Online ahead of print.NO ABSTRACTPMID:42001158 | DOI:10.1186/s12967-026-08166-2

X Xingrong Zheng

Impact of cardiohepatic syndrome on postoperative mortality in heart failure patients with reduced ejection fraction undergoing coronary artery bypass grafting

No abstractJ Cardiothorac Surg. 2026 Apr 18. doi: 10.1186/s13019-026-03999-w. Online ahead of print.NO ABSTRACTPMID:42001144 | DOI:10.1186/s13019-026-03999-w

Ş Şahin Yılmaz