Clin Rheumatol. 2025 Nov 26. doi: 10.1007/s10067-025-07824-y. Online ahead of print.ABSTRACTBACKGROUND: Patients with rheumatoid arthritis (RA) face significantly elevated cardiovascular risks, yet the underlying immunological mechanisms remain incompletely understood, particularly in refractory RA
EMBO Mol Med. 2025 Nov 26. doi: 10.1038/s44321-025-00335-y. Online ahead of print.ABSTRACTObesity is a major global health challenge, and promoting the browning of white adipose tissue (WAT) represents a promising therapeutic strategy. However, pharmacological approaches to induce adipose thermogene
Nat Aging. 2025 Nov 26. doi: 10.1038/s43587-025-01016-8. Online ahead of print.ABSTRACTAging and age-related diseases share convergent pathways at the proteome level. Here, using plasma proteomics and machine learning, we developed organismal and ten organ-specific aging clocks in the UK Biobank (n
Commun Biol. 2025 Nov 26;8(1):1696. doi: 10.1038/s42003-025-09097-2.ABSTRACTAging is accompanied by progressive vascular dysfunction, but its effects on skin aging remain poorly understood. Although endothelial cell (EC) senescence is implicated in various age-related diseases, its specific role in
NPJ Digit Med. 2025 Nov 26;8(1):721. doi: 10.1038/s41746-025-02099-8.ABSTRACTThe effectiveness of digital health management (DM) in post-discharge care for patients with coronary artery disease (CAD) remains insufficiently explored, particularly across public health emergencies. A total of 24,129 pa
NPJ Digit Med. 2025 Nov 26. doi: 10.1038/s41746-025-02164-2. Online ahead of print.ABSTRACTWhether artificial intelligence (AI) analysis of single-lead ECG (1 L ECG) can predict incident AF is unknown. In the VITAL-AF trial (ClinicalTrials.gov NCT03515057, registered 2/24/2021) of primary care patie
CVIR Endovasc. 2025 Nov 27;8(1):103. doi: 10.1186/s42155-025-00626-y.ABSTRACTBACKGROUND: Femoropopliteal diffuse calcified occlusions (FPDCOs) are challenging, especially in high-bleeding-risk patients for whom a stentless strategy is preferred. We introduce FRAP-CROSS, combining Fracking and Rendez
Nat Rev Neurol. 2025 Nov 26. doi: 10.1038/s41582-025-01161-z. Online ahead of print.ABSTRACTRestless legs syndrome (RLS) and periodic limb movements (PLMs) are increasingly recognized as risk factors for cerebrovascular and cardiovascular diseases, particularly stroke. Conversely, stroke can precipi
Sci Rep. 2025 Nov 27. doi: 10.1038/s41598-025-26455-6. Online ahead of print.ABSTRACTDiverticulitis is a common and morbid colorectal disease that recurs after an initial attack in up to 30% of patients. Elective surgery to remove the affected portion of the colon is an effective intervention to pre
Sci Rep. 2025 Nov 26;15(1):42219. doi: 10.1038/s41598-025-26322-4.ABSTRACTElevated levels of blood-based biomarkers such as neurofilament light chain (NfL) and neuron-specific enolase (NSE) are associated with poor neurological outcome after out-of-hospital cardiac arrest (OHCA). This study investig
Sci Rep. 2025 Nov 26;15(1):42081. doi: 10.1038/s41598-025-26159-x.ABSTRACTTransfusion-related acute lung injury (TRALI) is a potentially fatal transfusion reaction. It can be caused by the transfusion of proteins, lipids, and extracellular vesicles that accumulate in blood components during routine
Sci Rep. 2025 Nov 26;15(1):42092. doi: 10.1038/s41598-025-26147-1.ABSTRACTExtensive research has explored the use of machine perfusion to repair liver grafts, among these, interventions targeting mitochondrial repair are gaining attention due to its central role in ischemia-reperfusion injury and gr
Sci Rep. 2025 Nov 26;15(1):42064. doi: 10.1038/s41598-025-26092-z.ABSTRACTThis study examined the effects of the mixture of probiotics Lactobacillus (Lactobacillus rhamnosus, Lactobacillus fermentum, and Lactobacillus brevis) against cardiotoxicity induced by cisplatin (CP) in rats by monitoring mar
Sci Rep. 2025 Nov 26;15(1):42139. doi: 10.1038/s41598-025-25958-6.ABSTRACTRemnant cholesterol (RC) has emerged as a novel lipid parameter reflecting the residual risk of atherogenic dyslipidemia beyond low-density lipoprotein cholesterol (LDL-C). Previous studies have demonstrated that elevated RC a
Sci Rep. 2025 Nov 26;15(1):42083. doi: 10.1038/s41598-025-26150-6.ABSTRACTThe aging population faces significant health challenges, with sleep disturbances emerging as a critical yet often overlooked issue. Poor sleep quality is associated with various adverse health outcomes, including higher risks
Nat Commun. 2025 Nov 26. doi: 10.1038/s41467-025-66597-9. Online ahead of print.ABSTRACTCardiac fibrosis is mediated by the persistent activity of myofibroblasts, which differentiates from resident cardiac fibroblasts in response to tissue damage and stress signals. The signaling pathways and transc
Nat Commun. 2025 Nov 26. doi: 10.1038/s41467-025-66598-8. Online ahead of print.ABSTRACTMass General Brigham, an integrated healthcare system based in the Greater Boston area of Massachusetts, annually serves 1.5 million patients. We established the Mass General Brigham Biobank (MGBB), currently enc
No abstractRheumatology (Oxford). 2025 Nov 26:keaf619. doi: 10.1093/rheumatology/keaf619. Online ahead of print.NO ABSTRACTPMID:41298336 | DOI:10.1093/rheumatology/keaf619
Interdiscip Cardiovasc Thorac Surg. 2025 Nov 26:ivaf273. doi: 10.1093/icvts/ivaf273. Online ahead of print.ABSTRACTOBJECTIVES: Mechanical valve replacement is often used as the therapeutic option in valvular heart surgery in children. Evidence suggests that this should change to provide optimal long
Catheter Cardiovasc Interv. 2025 Nov 26. doi: 10.1002/ccd.70377. Online ahead of print.ABSTRACTEndomyocardial fibrosis (EMF) is a rare form of restrictive cardiomyopathy associated with eosinophilic disorders, characterized by apical subendocardial fibrosis and thrombus formation. Cardiac magnetic r
J Hum Nutr Diet. 2025 Dec;38(6):e70168. doi: 10.1111/jhn.70168.ABSTRACTBACKGROUND: Food insecurity is a major public health concern for residents of the South Bronx. Currently, one-third of Bronxites receive federal food assistance in the form of the public benefit, the Supplemental Nutrition Assist
BMJ Open. 2025 Nov 26;15(11):e101988. doi: 10.1136/bmjopen-2025-101988.ABSTRACTOBJECTIVES: This study aimed to explore the psychosocial adaptation processes and coping methods among patients with diabetic retinopathy (DR), emphasising the importance of understanding their lived experiences.DESIGN: A
BMJ Case Rep. 2025 Nov 26;18(11):e269325. doi: 10.1136/bcr-2025-269325.ABSTRACTCongenital absence of the right coronary artery (RCA) is an extremely rare coronary anomaly that may occur in isolation or in association with other congenital heart defects. We report the case of a woman in her early 30s
BMJ Case Rep. 2025 Nov 26;18(11):e266549. doi: 10.1136/bcr-2025-266549.ABSTRACTA middle childhood boy presented with fatigue, pallor and vomiting that had been persistent for half a month and significantly worsened over the past day. On clinical examination, he exhibited tachycardia with a heart rat
