FASEB J. 2026 Apr 30;40(8):e71769. doi: 10.1096/fj.202504897R.ABSTRACTIschemia-reperfusion injury severely impacts the heart and brain, and although ferroptosis is a key therapeutic target, the role of interleukin-6 in regulating ferroptosis during cardiac and cerebral I/R remains unclear. In vitro
Cardiovasc Ther. 2026;2026(1):e1649836. doi: 10.1155/cdr/1649836.ABSTRACTBACKGROUND: Although laxatives are commonly used for constipation in critically ill patients with acute myocardial infarction (AMI), the optimal initial choice is unclear. We are aimed at comparing the clinical outcomes of init
Vasc Endovascular Surg. 2026 Apr 10:15385744261441979. doi: 10.1177/15385744261441979. Online ahead of print.ABSTRACTBackgroundWhile chronic kidney disease (CKD) has been identified as a risk factor for mortality in patients with aortic diseases, its impact on the outcomes of type A aortic dissectio
J Food Sci. 2026 Apr;91(4):e71035. doi: 10.1111/1750-3841.71035.ABSTRACTHyperlipidemia, a common metabolic disorder marked by elevated serum lipids like total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C), raises risks for cardiovascular diseases, atherosclero
J Investig Med. 2026 Apr 10:10815589261444736. doi: 10.1177/10815589261444736. Online ahead of print.ABSTRACTBACKGROUND: Current evidence reveals that the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score demonstrates good accuracy in forecasting cardiovascular disease (CVD). This research
Hydrogen sulfide (H(2)S) exhibits anti-inflammatory, anti-apoptotic, and antioxidant effects. However, the central nervous system regulatory mechanisms of H(2)S in hypertension remain unclear. This study aimed to investigate the regulatory effects of H(2)S on the PERK/TXNIP/NLRP3 pathway and the par
Vasc Endovascular Surg. 2026 Apr 10:15385744261441931. doi: 10.1177/15385744261441931. Online ahead of print.ABSTRACTRenal arteriovenous fistula (RAVF) is a rare vascular anomaly, and it becomes exceedingly uncommon when accompanied by a renal vein aneurysm (RVA). While several cases of renal artery
Mol Ther. 2026 Apr 9:S1525-0016(26)00276-5. doi: 10.1016/j.ymthe.2026.04.011. Online ahead of print.ABSTRACTResmetirom is an oral, liver-targeted medication that selectively activates the thyroid hormone receptor beta (THRB) and thereby targets multiple pathophysiological mechanisms of metabolic dys
Oral Dis. 2026 Apr 10. doi: 10.1111/odi.70326. Online ahead of print.ABSTRACTOBJECTIVES: This study assessed oral health-related quality of life in individuals with and without obesity, and investigated its association with socioeconomic-demographic characteristics, lifestyle habits, health conditio
Gut Microbes. 2026 Dec 31;18(1):2657047. doi: 10.1080/19490976.2026.2657047. Epub 2026 Apr 10.ABSTRACTPrimary aldosteronism (PA), a major cause of secondary hypertension, is characterized by autonomous aldosterone overproduction. Although the gut microbiota is closely linked to blood pressure regula
Cardiooncology. 2026 Apr 10;12(1):50. doi: 10.1186/s40959-026-00452-8.ABSTRACTFluoropyrimidines, including 5-fluorouracil (5-FU), used in the treatment of patients with gastrointestinal malignancies, are associated with cardiotoxicity. Although the mechanism of this cardiotoxicity remains unknown, r
Stem Cell Res Ther. 2026 Apr 10. doi: 10.1186/s13287-026-04996-5. Online ahead of print.ABSTRACTCardiovascular research and drug development remain constrained by the limited translational relevance of conventional animal and in vitro cellular models, which represent a major bottleneck in the field.
No abstractDiabetol Metab Syndr. 2026 Apr 10. doi: 10.1186/s13098-026-02154-8. Online ahead of print.NO ABSTRACTPMID:41963967 | DOI:10.1186/s13098-026-02154-8
BMC Med. 2026 Apr 10;24(1):229. doi: 10.1186/s12916-026-04849-1.ABSTRACTBACKGROUND: The global rise in obesity prevalence poses a major health challenge due to its links to hypertension, stroke, type 2 diabetes, cardiovascular disease, depression, and cancer. Effective non-pharmacological strategies
No abstractBMC Geriatr. 2026 Apr 10. doi: 10.1186/s12877-026-07433-7. Online ahead of print.NO ABSTRACTPMID:41963841 | DOI:10.1186/s12877-026-07433-7
Bull Math Biol. 2026 Apr 11;88(5):79. doi: 10.1007/s11538-026-01645-z.ABSTRACTSmooth muscle cells (SMCs) play a fundamental role in the development of atherosclerotic plaques. They ingest lipids in a similar way to monocyte-derived macrophages (MDMs) in the plaque. This can stimulate SMCs to undergo
No abstractHypertens Res. 2026 Apr 10. doi: 10.1038/s41440-026-02635-3. Online ahead of print.NO ABSTRACTPMID:41963532 | DOI:10.1038/s41440-026-02635-3
Nat Commun. 2026 Apr 10. doi: 10.1038/s41467-026-71680-w. Online ahead of print.ABSTRACTThe COVID-19 pandemic, caused by SARS-CoV-2, has underscored the urgency of understanding viral entry mechanisms to develop effective therapeutic strategies. SARS-CoV-2 primarily exploits angiotensin-converting e
Nat Commun. 2026 Apr 10. doi: 10.1038/s41467-026-71580-z. Online ahead of print.ABSTRACTDoxorubicin-induced cardiomyopathy (DiCM) involves impaired clearance of apoptotic cardiomyocytes (efferocytosis) by cardiac macrophages. This study reveals a central role for the MARCH2-NR1H2 axis in this proces
J Cardiovasc Comput Tomogr. 2026 Apr 9:S1934-5925(26)00062-6. doi: 10.1016/j.jcct.2026.03.011. Online ahead of print.ABSTRACTBACKGROUND: Despite a significant association of atherogenic index of plasma (AIP) with plasma atherogenicity as well as insulin resistance and new onset of diabetes, data on
Prim Care Diabetes. 2026 Apr 9:S1751-9918(26)00076-8. doi: 10.1016/j.pcd.2026.04.004. Online ahead of print.ABSTRACTIn this pilot study, we identified rural veterans with chronic kidney disease and type 2 diabetes who have an indication for SGLT2i or GLP-1 RA but not yet on either of these agents. N
Atherosclerosis. 2026 Apr 2:120724. doi: 10.1016/j.atherosclerosis.2026.120724. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Cholesterol efflux capacity (CEC) is robust biomarker for atherosclerotic cardiovascular disease (ASCVD). However, cell-based CEC assays require complex procedures that
Obes Res Clin Pract. 2026 Apr 10:S1871-403X(26)00025-6. doi: 10.1016/j.orcp.2026.03.005. Online ahead of print.ABSTRACTBACKGROUND: Autonomic dysfunction is a pathway linking obesity to cardiovascular disease, contributing to hypertension and impaired pressor control. Individuals with obesity often s
J Int Med Res. 2026 Apr;54(4):3000605261436654. doi: 10.1177/03000605261436654. Epub 2026 Apr 10.ABSTRACTObjectiveHigh-sensitivity C-reactive protein, a key inflammatory biomarker, can indicate the risk of cardiovascular diseases. The cardiometabolic index has been associated with metabolic and card
