West J Emerg Med. 2026 May 14;27(3):614-620. doi: 10.5811/westjem.48347.ABSTRACTINTRODUCTION: Hypertension is a recognized risk factor for acute coronary syndrome and major adverse cardiovascular events, yet its influence on high sensitivity cardiac troponin (hscTn) concentrations and on the prognos
Ann Intern Med. 2026 Jun 9. doi: 10.7326/ANNALS-26-01311. Online ahead of print.ABSTRACTUpdated U.S. and international hypertension guidelines reflect new studies and analyses that support changes in hypertension management. The 2025 U.S. guideline for prevention, detection, evaluation, and manageme
Age Ageing. 2026 Jun 1;55(6):afag167. doi: 10.1093/ageing/afag167.ABSTRACTBACKGROUND: With the rise in older population globally, the optimal blood pressure (BP) target for antihypertensive therapy in those aged 60 and above remains to be evaluated in the real-world practice. This study evaluated th
JCI Insight. 2026 Jun 8;11(11):e190175. doi: 10.1172/jci.insight.190175. eCollection 2026 Jun 8.ABSTRACTTranscriptional reprogramming has an important role in kidney glomerular disease. Using in vivo murine models of podocyte injury, we studied the roles of the FOXC2 and WT1 transcription factors (T
Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2535879123. doi: 10.1073/pnas.2535879123. Epub 2026 Jun 8.ABSTRACTCyclic GMP-AMP synthase (cGAS) and its downstream effector, stimulator of interferon genes (STING), form a key cytosolic DNA-sensing pathway that drives innate immune activation and proin
J Cardiovasc Nurs. 2026 Jun 8. doi: 10.1097/JCN.0000000000001338. Online ahead of print.ABSTRACTBACKGROUND: Adults with cardiovascular disease frequently experience anxiety, sleep disturbance, and challenges with long-term treatment adherence. These factors are associated with poorer quality of life
WMJ. 2026;125(2):283-285.ABSTRACTBACKGROUND: Infant mortality from congenital cardiovascular defects (CCDs) is the leading cause of death among individuals with birth defects.METHODS: A descriptive analysis of infant mortality due to CCDs in Wisconsin and the United States was performed using data f
J Clin Endocrinol Metab. 2026 Jun 8:dgag224. doi: 10.1210/clinem/dgag224. Online ahead of print.ABSTRACTCONTEXT: The importance of utilizing continuous glucose monitoring (CGM) to optimize glycemic profiles and thereby prevent the onset of diabetic complications in patients with type 1 diabetes has
Eur J Prev Cardiol. 2026 Jun 8:zwag303. doi: 10.1093/eurjpc/zwag303. Online ahead of print.ABSTRACTBACKGROUND: As the primary circadian entrainer, light may affect cardiovascular health through circadian disruption or enhancement, depending on its timing. Epidemiologic studies on the associations of
Eur J Prev Cardiol. 2026 Jun 8:zwag314. doi: 10.1093/eurjpc/zwag314. Online ahead of print.ABSTRACTThe persistent global rise in atherosclerotic cardiovascular disease (ASCVD) challenges the effectiveness of current risk factor-based algorithms in primary prevention. Most myocardial infarctions occu
J Vis Exp. 2026 May 19;(231). doi: 10.3791/71212.ABSTRACTHeart failure (HF) is a major global health burden characterized by impaired cardiac function. It may arise from reduced systolic function or abnormal diastolic relaxation, as seen in heart failure with preserved ejection fraction (HFpEF). Rel
J Vis Exp. 2026 May 22;(231). doi: 10.3791/69341.ABSTRACTDiastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) are significant contributors to pulmonary hypertension (PH) due to left heart disease. Standard in vivo evaluation of relaxation abnormalities in preclinical mode
PLoS One. 2026 Jun 8;21(6):e0350086. doi: 10.1371/journal.pone.0350086. eCollection 2026.ABSTRACTPeople with HIV (PWH) experience elevated cardiovascular disease risk compared to people without HIV. Stimulant use may further increase subclinical myocardial injury among PWH, but data on cardiovascula
J Vis Exp. 2026 May 22;(231). doi: 10.3791/69541.ABSTRACTCardiovascular diseases, especially arrhythmias, are a leading cause of death worldwide. This highlights the need for automated systems that can detect and diagnose these conditions early. This research introduces a deep learning model that id
J Appl Physiol (1985). 2026 Jun 8. doi: 10.1152/japplphysiol.00329.2026. Online ahead of print.ABSTRACTIn vitro fertilization (IVF) is an effective treatment for infertility; however, IVF may increase future maternal cardiovascular disease (CVD) risk. Vascular dysfunction, characterized by increased
JAMA. 2026 Jun 8. doi: 10.1001/jama.2026.8806. Online ahead of print.ABSTRACTIMPORTANCE: Cyanotic congenital heart diseases, which occur in approximately 0.2% of live births in the United States, have high mortality rates if untreated, but survival to adulthood is common with current surgical interv
J Med Econ. 2026 Dec;29(1):1595-1616. doi: 10.1080/13696998.2026.2675850. Epub 2026 Jun 8.ABSTRACTOBJECTIVES: To explore the cost-effectiveness of mavacamten + beta-blocker/calcium channel blocker therapy (BB/CCB) versus BB/CCB monotherapy for the treatment of symptomatic obstructive hypertrophic ca
Clin J Am Soc Nephrol. 2026 Jun 8. doi: 10.2215/CJN.0000001139. Online ahead of print.ABSTRACTHypertension is a major contributor to kidney and cardiovascular morbidity and mortality in chronic kidney disease (CKD) yet achieving blood pressure (BP) control remains challenging. Team-based care, parti
Health Psychol. 2026 Jun 8:10.1037/hea0001615. doi: 10.1037/hea0001615. Online ahead of print.ABSTRACTOBJECTIVE: Despite robust evidence linking psychological stress to cardiovascular disease (CVD), explanations for how risk is transmitted are limited by a lack of ecologically valid models. Recent c
J Med Chem. 2026 Jun 8. doi: 10.1021/acs.jmedchem.6c00652. Online ahead of print.ABSTRACTAtherosclerosis is now widely recognized as a chronic inflammatory condition driven by the recruitment of leukocytes, with CXCR4 playing a critical role in plaque inflammation and disease progression. In this st
JAMA Neurol. 2026 Jun 8. doi: 10.1001/jamaneurol.2026.1634. Online ahead of print.ABSTRACTIMPORTANCE: Accurate diagnosis of neurodegenerative movement disorders is challenging because of a lack of in vivo biomarkers, overlapping clinical features, and a delay in the emergence of pathognomonic featur
Sci China Life Sci. 2026 Jun 5. doi: 10.1007/s11427-025-3308-1. Online ahead of print.ABSTRACTDyslipidemia is an important risk factor for coronary artery disease (CAD). However, the relationship between high-density lipoprotein (HDL) antioxidant function and plasma lipid profile has not been fully
Curr Atheroscler Rep. 2026 Jun 8;28(1):61. doi: 10.1007/s11883-026-01431-1.ABSTRACTPURPOSE OF REVIEW: Familial hypercholesterolemia (FH) is a common monogenic lipid disorder, characterized by lifelong elevated low-density lipoprotein cholesterol (LDL-C) and a markedly increased risk of atherosclerot
Clin Exp Nephrol. 2026 Jun 8. doi: 10.1007/s10157-026-02898-7. Online ahead of print.ABSTRACTBACKGROUND: Finerenone improves cardiovascular and kidney outcomes in patients with type 2 diabetes and chronic kidney disease; however, hyperkalemia remains a safety concern in routine practice. We evaluate
