Microplastics in bottled water and human health outcomes: a systematic review of multi-organ toxicity and mechanistic pathways

J Environ Sci Health C Toxicol Carcinog. 2026 Aug 29:1-21. doi: 10.1080/26896583.2026.2722385. Online ahead of print.ABSTRACTThis systematic review synthesized evidence on the health effects of microplastic exposure, with emphasis on organ-specific toxicity, molecular mechanisms, and implications fo

R Rehoboth Chinyere Uwaga

Hydroxychloroquine-Induced Cardiotoxicity in the Setting of a False Positive PYP Scan

JACC Case Rep. 2026 Aug 29:109894. doi: 10.1016/j.jaccas.2026.109894. Online ahead of print.ABSTRACTBACKGROUND: Hydroxychloroquine (HCQ)-induced cardiomyopathy may mimic transthyretin cardiac amyloidosis on technetium-99m pyrophosphate (PYP) scans, producing false positive results. This diagnostic c

L Leonardo Wagner Florencio Dos Santos

Efficacy of Aficamten vs Metoprolol According to Pretrial Beta-Blocker Treatment in Obstructive Hypertrophic Cardiomyopathy: Insights From MAPLE-HCM

JACC Heart Fail. 2026 Aug 29:103352. doi: 10.1016/j.jchf.2026.103352. Online ahead of print.ABSTRACTBACKGROUND: The MAPLE-HCM trial demonstrated the superiority of monotherapy with aficamten vs metoprolol at improving clinical endpoints in obstructive hypertrophic cardiomyopathy (oHCM). The impact o

F Fernando Dominguez

Risk of Myocarditis and Pericarditis With Bivalent RSV Prefusion F Protein-Based Vaccine: A Safety Analysis of the Extended DAN-RSV Trial

No abstractJ Am Coll Cardiol. 2026 Aug 29:S0735-1097(26)07510-8. doi: 10.1016/j.jacc.2026.08.027. Online ahead of print.NO ABSTRACTPMID:42667277 | DOI:10.1016/j.jacc.2026.08.027

M Marat Yafasov

Development and external validation of the SCORE2 models in Latin America and the Caribbean (SCORE2-LAC) to estimate 10-year cardiovascular disease risk

Eur Heart J. 2026 Aug 29:ehag698. doi: 10.1093/eurheartj/ehag698. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Despite the high burden of cardiovascular disease (CVD) in Latin America and the Caribbean (LAC), risk prediction models adapted for use in LAC populations remain limited. The aim of

S Stella Bijkerk

Distribution and Clinical Utility of the Kidney Disease Improving Global Outcomes Chronic Kidney Disease Risk Classification in Patients Undergoing Atrial Fibrillation Ablation

J Am Heart Assoc. 2026 Aug 29:e049254. doi: 10.1161/JAHA.126.049254. Online ahead of print.ABSTRACTBACKGROUND: Chronic kidney disease (CKD) is a key component of the cardiovascular-kidney-metabolic framework. However, in patients undergoing atrial fibrillation ablation, the distribution of CKD acros

H Hironori Ishiguchi

Retrospective Cohort Study of Peripheral Blood miR-486-3p Levels in Patients with Acute Cerebral Infarction and Obstructive Sleep Apnea Syndrome

J Vis Exp. 2026 Aug 28;(234). doi: 10.3791/72643.ABSTRACTAcute cerebral infarction (ACI) complicated with obstructive sleep apnea syndrome (OSAS) confers a high risk of stroke recurrence and death, yet effective biomarkers for this comorbid condition remain limited. This retrospective cohort study e

Z Zhihan Liu

Diagnosis and Treatment of Patent Foramen Ovale-associated Cryptogenic Stroke

J Vis Exp. 2026 Aug 28;(234). doi: 10.3791/72345.ABSTRACTPatent foramen ovale (PFO) is an important cause of cryptogenic stroke (CS), and its pathogenic mechanisms involve paradoxical embolism, in situ thrombus, hemodynamic changes caused by atrial remodeling, and high-risk anatomical features such

L Liju Liang

Myosin Heavy-Chain-Associated RNA Transcript for Cardiopulmonary Recovery Prediction in High-Intensity Interval Training for Coronary Artery Disease

J Vis Exp. 2026 Aug 28;(234). doi: 10.3791/71478.ABSTRACTThis study highlights the expression characteristics of MHRT in CAD and analyzes its predictive potential regarding HIIT intervention on cardiopulmonary function and quality of life in CAD patients. A total of 88 CAD patients were enrolled, an

Y Yanan Zhao

Criteria for the diagnosis of cardiogenic shock-European perspective: A Clinical Consensus Statement of the Association for Acute CardioVascular Care, the Heart Failure Association, and the European Association of Percutaneous Cardiovascular Interventions of the ESC

Eur Heart J Acute Cardiovasc Care. 2026 Aug 29;15(8):634-648. doi: 10.1093/ehjacc/zuag100.ABSTRACTCardiogenic shock is a complex clinical syndrome with a high mortality risk. As heterogeneity of patient presentation is high and diagnosis not standardized, a timely diagnosis and thus initiation of tr

H Hoong Sern Lim

Admission-Parameter Nomogram for Early Neurological Deterioration after Minor Small Subcortical Infarction: A Retrospective Cohort Study

J Vis Exp. 2026 Aug 28;(234). doi: 10.3791/71645.ABSTRACTEarly neurological deterioration (END) was common after minor subcortical infarction, but prediction was complicated by heterogeneous mechanisms, including intrinsic small-vessel disease and branch atheromatous disease (BAD). A retrospective a

Y Ying Zhang

Tocilizumab Is Associated With a Lower Incidence of Major Adverse Cardiovascular Events in Giant Cell Arteritis

Circulation. 2026 Aug 29. doi: 10.1161/CIRCULATIONAHA.126.080365. Online ahead of print.ABSTRACTBACKGROUND: Giant cell arteritis is associated with increased cardiovascular risk, potentially related to systemic inflammation, vascular injury, and glucocorticoid exposure. Whether steroid-sparing thera

A Alexis F Guedon

Warfarin Dose Adjustment During Rifampicin Therapy: A Case Report with Practical Monitoring Implications

J Vis Exp. 2026 Aug 28;(234). doi: 10.3791/73270.ABSTRACTWarfarin management is challenging because its anticoagulant effect is influenced by drug-drug interactions and individual variability. Rifampicin is a potent inducer of cytochrome P450 enzymes and can substantially reduce warfarin efficacy, m

X Xi Li

Local vs systemic inflammation and outcomes after percutaneous coronary intervention

Eur Heart J. 2026 Aug 29:ehag731. doi: 10.1093/eurheartj/ehag731. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Inflammation influences outcomes after percutaneous coronary intervention (PCI) in coronary artery disease (CAD). This study aimed to evaluate the relative and combined prognostic val

Z Zixiang Ye

Stress-induced trained immunity-A key mechanism linking psychosocial stress, atherosclerosis, and cardiovascular disease

FEBS Lett. 2026 Aug 29. doi: 10.1002/1873-3468.70447. Online ahead of print.ABSTRACTAlthough chronic psychosocial stress is a well-established independent risk factor for cardiovascular disease (CVD), the underlying mechanisms linking stress to CVD remain incompletely understood. Here, we review cli

D Dineke C W Touw

Periprocedural Mortality Risk After Elective Atrial Fibrillation Ablation in Japan

JAMA Netw Open. 2026 Aug 3;9(8):e2634516. doi: 10.1001/jamanetworkopen.2026.34516.ABSTRACTIMPORTANCE: Evidence on the safety of atrial fibrillation ablation during rapid growth in both procedural volume and the number of hospitals performing it remains inconsistent. Although clinical registries and

K Koichi Inoue

Predicting Single-Cell Perturbation Responses Across Biological Contexts With a Deep Generative Model Integrating Optimal Transport

Adv Sci (Weinh). 2026 Aug 29:e77461. doi: 10.1002/advs.77461. Online ahead of print.ABSTRACTPredicting how single cells respond to perturbations is a central problem in computational biology, with potential relevance to emerging artificial intelligence virtual cell (AIVC) research and drug-discovery

J Jialiang Wang

Burden of diagnosed and undetected hyperkalemia in Spain: Clinical characteristics, management, healthcare resource utilization, and costs

J Nephrol. 2026 Aug 29:aajag234. doi: 10.1093/joneph/aajag234. Online ahead of print.ABSTRACTBACKGROUND: Management of hyperkalemia (HK) is challenging and suboptimal. This study analyzed the prevalence of HK and undetected HK, as well as management, clinical outcomes, healthcare resource utilizatio

J José Luis Gorriz

ADAR RNA editing for cardiovascular disease: Targeting B4GALT1 to modulate lipid metabolism through reduced galactosyltransferase activity

Mol Ther Nucleic Acids. 2026 Jul 9;37(3):103001. doi: 10.1016/j.omtn.2026.103001. eCollection 2026 Sep 8.ABSTRACTCardiovascular disease remains a leading cause of mortality despite current therapies targeting low-density lipoprotein cholesterol (LDL-C). Beta-1,4-galactosyltransferase 1 (B4GALT1), a

F Francesco De Chiara

Aortic valve stenosis and physical activity at high altitude in a female trekker: sex-specific considerations and the added value of a sports cardiology team-a case report

Eur Heart J Case Rep. 2026 Aug 17;10(9):ytag593. doi: 10.1093/ehjcr/ytag593. eCollection 2026 Sep.ABSTRACTBACKGROUND: Recommendations for high-altitude exposure in individuals with cardiovascular disease are largely based on expert opinion. This report details sport- and sex-specific recommendations

M Mathijs Bodde

Reducing Sex Disparities in Statin Therapy Among Female Veterans With Type 2 Diabetes and/or Cardiovascular Disease

Fed Pract. 2025 Nov;42(Suppl6):S1-S5d. doi: 10.12788/fp.0624. Epub 2025 Nov 10.ABSTRACTBACKGROUND: Female veterans have higher rates of cardiovascular disease (CVD) compared with the civilian population. Medical management with statins (3-hydroxy-3-methyl-glutaryl-coenzmye A reductase inhibitors) is

S Schylar Cheyenne Hathaway

Fifth Universal Definition of Myocardial Infarction (2026): On behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the Society of Thoracic Surgeons (STS) Affirmation of Value by the Society for Cardiovascular Angiography and Interventions (SCAI)

No abstractGlob Heart. 2026 Aug 28;21(1):64. doi: 10.5334/gh.1578. eCollection 2026.NO ABSTRACTPMID:42666939 | PMC:PMC13523810 | DOI:10.5334/gh.1578

N Nicholas L Mills

Income, Geography, and Etiology as Factors Associated with Valve Replacement Outcomes: A Nationwide Cohort of 63,426 Patients in a Middle-Income Country

Glob Heart. 2026 Aug 25;21(1):63. doi: 10.5334/gh.1581. eCollection 2026.ABSTRACTBACKGROUND: Heart valve disease is a growing cause of mortality and disability worldwide, disproportionately burdening low- and middle-income countries (LMICs), where rheumatic heart disease remains a major etiology and

L Leonardo Dexheimer da Silva

Health care utilization for premature ventricular complexes in acute settings

Heart Rhythm O2. 2026 May 8;7(8):1518-1527. doi: 10.1016/j.hroo.2026.04.026. eCollection 2026 Aug.ABSTRACTBACKGROUND: Premature ventricular complexes (PVCs) are common; however, their burden in acute health care settings is not well characterized. In parallel, therapies, particularly catheter ablati

J Jean Jacques Noubiap