An integrated cardiometabolic genetic testing program in a predominantly Hispanic population within a community setting

Genet Med. 2026 May 7:102595. doi: 10.1016/j.gim.2026.102595. Online ahead of print.ABSTRACTPURPOSE: This study aimed to apply cardiometabolic genetic testing in a community setting with a predominantly Hispanic population and assess feasibility and perspectives towards genetic testing.METHODS: A ge

B Bo Yuan

Rationale and Design of CARDIO-TTRansform, a Phase 3 Trial of Eplontersen in Transthyretin Amyloid Cardiomyopathy

Circ Heart Fail. 2026 May 9:e014205. doi: 10.1161/CIRCHEARTFAILURE.126.014205. Online ahead of print.ABSTRACTBACKGROUND: Transthyretin amyloidosis with cardiomyopathy is a progressive, fatal disease characterized by deposition of extracellular misfolded transthyretin (TTR) in the myocardium. Eplonte

A Ahmad Masri

Dynamic changes in mean corpuscular volume could be integrated into longitudinal prediction frameworks for individualized risk assessment in the ICU setting: A retrospective study

Sci Prog. 2026 Apr-Jun;109(2):368504261438557. doi: 10.1177/00368504261438557. Epub 2026 May 9.ABSTRACTObjectiveTo evaluate whether early variability in mean corpuscular volume (MCV) during the first five days of intensive care unit stay is associated with in-hospital mortality in critically ill pat

M Markward Britsch

P-CAB vs. PPI for Upper Gastrointestinal Bleeding Prevention in Patients With Atherothrombotic Disease on Antithrombotic Therapy: A CDM Cohort Study

Aliment Pharmacol Ther. 2026 May 9. doi: 10.1111/apt.70719. Online ahead of print.ABSTRACTBACKGROUND: Randomised trials have suggested the benefit of potassium-competitive acid blockers (P-CABs) is superior to proton pump inhibitors (PPIs) for ulcer recurrence in high-risk aspirin users. However, re

M Min Joo Yoon

Clinical and cost-effectiveness of negative pressure wound therapy versus usual care for surgical wounds healing by secondary intention: the SWHSI 2 pragmatic RCT

Health Technol Assess. 2026 May;30(32):1-50. doi: 10.3310/GJIC1716.ABSTRACTBACKGROUND: Surgical wounds healing by secondary intention occur if a surgical wound is not closed or dehisces following primary closure. Surgical wounds healing by secondary intention are common and adversely affect patients

C Catherine Arundel

Construction of a Postoperative Complication Risk Model for Patients With Stanford Type A Aortic Dissection

J Clin Hypertens (Greenwich). 2026 May;28(5):e70248. doi: 10.1111/jch.70248.ABSTRACTTo identify risk factors for postoperative complications in Stanford Type A aortic dissection (TAAD) patients, a risk prediction model was developed and validated. The study included a specific cohort of TAAD patient

X Xiaohui Liu

Early Carotid Structural and Functional Changes Associated With Elevated Blood Pressure in Children: A Multimodal Ultrasound Study

J Clin Hypertens (Greenwich). 2026 May;28(5):e70271. doi: 10.1111/jch.70271.ABSTRACTChildhood hypertension is closely associated with cardiovascular disease in adulthood, and the carotid artery is one of the principal target organs affected by elevated blood pressure (BP). The purpose of this study

H Hui Wang

The Global, Regional, and National Burden of Cardiovascular Diseases Attributable to Household Air Pollution from 1990 to 2021: Findings from the Global Burden of Disease Study 2021

Biomed Environ Sci. 2026 Apr 20;39(4):447-463. doi: 10.3967/bes2025.141.ABSTRACTOBJECTIVE: This study investigates the global, regional, and national cardiovascular disease (CVD) burden caused by household air pollution (HAP) from 1990 to 2021 across regions, time periods, sexes, and age groups.METH

Z Ze Hao Zhao

Moving beyond Low-Density Lipoprotein cholesterol: apolipoprotein B and Lipoprotein (a) for sex-specific risk assessment of aortic stenosis in the UK Biobank

Eur J Prev Cardiol. 2026 May 8:zwag257. doi: 10.1093/eurjpc/zwag257. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Lipid abnormalities-particularly low-density lipoprotein cholesterol (LDL-c) and lipoprotein(a) [Lp(a)]-have been implicated in aortic stenosis (AS), yet translation into clinicall

W Wence Shi

Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease

Eur J Neurosci. 2026 May;63(9):e70536. doi: 10.1111/ejn.70536.ABSTRACTMicroglia, the resident innate immune cells of the central nervous system, play a pivotal role in the pathogenesis of Alzheimer's disease (AD). Microglia are now recognized as a highly dynamic and heterogeneous population whose mo

P Patricia Martínez-Tazo

Epidemiology of lentigo maligna and lentigo maligna melanoma in England between 2013-2023

Br J Dermatol. 2026 May 8:ljag177. doi: 10.1093/bjd/ljag177. Online ahead of print.ABSTRACTBACKGROUND: Lentigo maligna (LM) is a melanoma in situ usually found sun on exposed skin in older adults. Data on the risk of progression to lentigo maligna melanoma (LMM) are limited. Outcomes without surgica

D Dimitrios Karponis

An Uncommon Presentation of Heyde Syndrome: Absence of Visible Endoscopic Angiodysplasia With Resolution After Transcatheter Aortic Valve Replacement

Am J Case Rep. 2026 May 9;27:e951614. doi: 10.12659/AJCR.951614.ABSTRACTBACKGROUND Heyde syndrome (HS) is defined by the triad of aortic stenosis (AS), gastrointestinal bleeding, and acquired von Willebrand syndrome (avWS). Diagnosis can be challenging in elderly patients with multiple comorbidities

R Ronnie A Napoles

Impact of Cardiometabolic Risk Markers on the Incidence and Progression Arterial Stiffness in Patients With Prediabetes

J Diabetes. 2026 May;18(5):e70231. doi: 10.1111/1753-0407.70231.ABSTRACTBACKGROUND: Previous studies have reported that insulin resistance (IR), blood pressure, body mass index (BMI), and dyslipidemia are associated with arterial stiffness. However, limited evidence exists regarding these relationsh

Q Qi Sun

Integrated UPLC-QTOF-MS and Network Pharmacology for Predicting Active Constituents and Pharmacological Mechanisms of Yinxingye Tablets Against Oxidative Stress

Biomed Chromatogr. 2026 Jun;40(6):e70469. doi: 10.1002/bmc.70469.ABSTRACTYinxingye tablets have been extensively used for cardiovascular and cerebrovascular diseases; however, their specific constituents, antioxidant effects, and underlying mechanisms remain insufficiently defined. This study aimed

W Wenjing Zhao

Frailty trajectories and mortality prediction among Japanese community-dwelling older adults: a cohort study comparing time-based and age-based models

Arch Public Health. 2026 May 8. doi: 10.1186/s13690-026-01928-w. Online ahead of print.ABSTRACTBACKGROUND: Group-based trajectory modeling (GBTM) can be applied using either time-based or age-based approaches to identify frailty trajectories; however, the comparative effectiveness of the methods for

M Mengjiao Yang

Association of pericardial fat volume with risk of incident type 2 diabetes mellitus or major adverse cardiovascular events: Evidence from UK Biobank cohort study

Nutr Metab (Lond). 2026 May 8. doi: 10.1186/s12986-026-01127-y. Online ahead of print.ABSTRACTBACKGROUND: This study seeks to investigate the relationship between pericardial fat volume and the risk of developing type 2 diabetes mellitus (T2DM) and major adverse cardiovascular events (MACE).METHODS:

F Feng Hu

Phenotype-dependent effects of IL-17A inhibitors on lipid profiles in moderate-to-severe plaque psoriasis: a retrospective cohort study

Lipids Health Dis. 2026 May 9. doi: 10.1186/s12944-026-02974-7. Online ahead of print.ABSTRACTBACKGROUND: Psoriasis is associated with elevated cardiovascular risk, partly mediated through dyslipidemia and the interleukin-23/Th17 inflammatory axis. Interleukin-17A (IL-17A) inhibitors demonstrate sup

C Chao Wu

Impact of a mobile health education program on blood pressure and lipid profiles: a cohort study

BMC Public Health. 2026 May 8. doi: 10.1186/s12889-026-27656-y. Online ahead of print.ABSTRACTBACKGROUND: Hypertension and dyslipidemia are major risk factors for cardiovascular disease, and effective management of these conditions is essential for reducing long-term morbidity. Mobile health (mHealt

J Jae-Sik Jang

The physical activity health paradox: what is it, why might it happen, and where to go from here?

Int J Behav Nutr Phys Act. 2026 May 8. doi: 10.1186/s12966-026-01922-z. Online ahead of print.ABSTRACTBACKGROUND: The "physical activity health paradox" posits that physical activity done during work (occupational physical activity [OPA]) may not yield the health benefits consistently observed for l

T Tyler D Quinn

Actual use, intention to use, and user attitudes toward mobile health applications for coronary heart disease self-management: a systematic review and meta-analysis

BMC Med Inform Decis Mak. 2026 May 8. doi: 10.1186/s12911-026-03554-6. Online ahead of print.ABSTRACTBACKGROUND: Mobile Health applications (mHealth) have become a promising approach to support self-management of coronary heart disease (CHD). No previous studies have examined user acceptance constru

T Tesema Etefa Birhanu

Stent deformation and dislodgment into the aorta during mini-crush bifurcation PCI: a rare complication leading to emergency CABG

BMC Cardiovasc Disord. 2026 May 8. doi: 10.1186/s12872-026-05955-x. Online ahead of print.ABSTRACTBACKGROUND: Stent dislodgment during percutaneous coronary intervention (PCI) has become exceedingly rare with modern stent designs; however, it may still occur in complex bifurcation interventions. Whe

E Ezgi Çamlı Babayiğit

Proteomic and degradomic signatures of extracellular matrix remodeling in calcific aortic valve stenosis

Mol Med. 2026 May 8. doi: 10.1186/s10020-026-01499-0. Online ahead of print.ABSTRACTBACKGROUND: Aortic stenosis is a progressive fibro-inflammatory valvular disorder with major clinical burden and no disease-modifying pharmacological therapy. Defining molecular circuits associated with thrombo-infla

I Ilaria Iacobucci

Nitric oxide supplementation during extracorporeal resuscitation drives oxidative-inflammatory signaling and metabolic suppression in the post-cardiac arrest heart

Mol Med. 2026 May 8;32(1):72. doi: 10.1186/s10020-026-01468-7.ABSTRACTBACKGROUND: Myocardial dysfunction is a major determinant of mortality after cardiac arrest, yet the molecular events driving post-resuscitation injury remain incompletely understood. Nitric oxide (NO) has been proposed as a cardi

A Abou Bakr M Salama

Systolic blood pressure time-in-target range and kidney outcomes in patients with hypertension: Findings from the STEP trial

Chin Med J (Engl). 2026 May 8. doi: 10.1097/CM9.0000000000004118. Online ahead of print.ABSTRACTBACKGROUND: Time-in-target range (TTR) of systolic blood pressure (SBP) is determined by the proportion of time during which the SBP remains within a defined optimal range. The study aims to explore the a

M Miaomiao Zhuang