ITACARE-P

Diagnostic Criteria and Management of MELAS and Stroke-Like Episodes: Consensus-Based Statements

Eur J Neurol. 2026 Apr;33(4):e70588. doi: 10.1111/ene.70588.ABSTRACTBACKGROUND AND PURPOSE: Mitochondrial Encephalomyopathy, Lactic acidosis and Stroke-like episodes (MELAS) is a rare multisystem mitochondrial disorder with clinical heterogeneity. Diagnostic criteria and management strategies for ME

Michelangelo Mancuso

Evidence-Based Recommendations on the Use of Inclisiran in Patients With Chronic Kidney Disease

Nephrology (Carlton). 2026 Apr;31(4):e70206. doi: 10.1111/nep.70206.ABSTRACTIn patients with chronic kidney disease (CKD), the burden of atherosclerotic cardiovascular disease (ASCVD) remains distinctively high. Management of dyslipidaemia in individuals with CKD is essential yet often deficient due

Sourabh Sharma

Use of TaqMan array card to investigate bacterial isolates in diabetic foot ulcers

J Med Microbiol. 2026 Apr;75(4). doi: 10.1099/jmm.0.002113.ABSTRACTDiabetic foot disease is a major public health problem, with an annual National Health Service (NHS) expenditure exceeding £1 billion. Infection increases the risk of major amputation fivefold. Due to the polymicrobial nature of diab

Sarah Johnson-Lynn

Validation of Risk Perception Cut-Offs in Italian Brief PRHDS (PRHDS-BI): Implications for Primary Cardiovascular Prevention

High Blood Press Cardiovasc Prev. 2026 Mar 17. doi: 10.1007/s40292-026-00793-6. Online ahead of print.ABSTRACTINTRODUCTION: Effective cardiovascular (CV) prevention requires accurate risk estimation and patient engagement, which depends on perceived risk. The Perception of Risk of Heart Disease Scal

Rosa Debora

Combination of prolonged water fasting and GLP-1 for refractory morbid obesity: Case report

Eur J Clin Nutr. 2026 Apr 17. doi: 10.1038/s41430-026-01749-8. Online ahead of print.ABSTRACTINTRODUCTION: Water fasting involves completely abstaining from all caloric intake. Multiple studies have demonstrated that water fasting for up to 21 days is well-tolerated, but none focused on patients wit

Tiago Palmisano

Soft robotic devices for cardiovascular medicine

Nat Rev Cardiol. 2026 Apr 17. doi: 10.1038/s41569-026-01287-7. Online ahead of print.ABSTRACTConventional, rigid simulators and therapeutic devices for cardiovascular disease have several fundamental limitations, such as poor biomimetic fidelity, substantial surgical invasiveness and mismatch at the

Xing-Yu Ji

Thrombus composition identifies distinct etiologic phenotypes in embolic stroke of undetermined source

Neurol Sci. 2026 Apr 18;47(5):435. doi: 10.1007/s10072-026-09021-4.ABSTRACTBACKGROUND AND AIMS: Embolic stroke of undetermined source (ESUS) is biologically heterogeneous and often presumed cardioembolic (CE). We investigated whether thrombus composition can capture etiologic heterogeneity within ES

Ghil Schwarz

Platelet-rich plasma enhances post-conditioning recovery from testicular ischemia-reperfusion injury: a novel experimental approach

Sci Rep. 2026 Apr 17;16(1):12709. doi: 10.1038/s41598-026-46712-6.ABSTRACTThe present study aimed to investigate the protective effects of platelet-rich plasma combined with post-conditioning on testicular ischemia-reperfusion injury in a rat model. Thirty-two adult male rats were randomly assigned

None Amena-Elmongy

Rare regulatory mutations disrupt mesenchymal molecular programs driving endocardial cushion formation in bicuspid aortic valve

Nat Commun. 2026 Apr 18;17(1):3587. doi: 10.1038/s41467-026-71758-5.ABSTRACTBicuspid aortic valve, a prevalent congenital malformation, predisposes individuals to severe complications. Although the condition exhibits substantial heritability, known protein-coding and common regulatory mutations expl

Artemy Zhigulev

Dysfunction of the episodic memory network in the Alzheimer's disease cascade

Nat Commun. 2026 Apr 17;17(1):3578. doi: 10.1038/s41467-026-71831-z.ABSTRACTAlzheimer's disease (AD) is a major cause of dementia and cognitive decline. Here, we assessed how episodic memory (EM) network dysfunction, a hallmark of AD, is related to the longitudinal progression of AD biomarkers, neur

René Lattmann

Repairing the Infarcted Heart: Preclinical Outcomes of Cardiac Tissue Engineering

No abstractStem Cell Rev Rep. 2026 Apr 17. doi: 10.1007/s12015-026-11125-5. Online ahead of print.NO ABSTRACTPMID:41996047 | DOI:10.1007/s12015-026-11125-5

Fatemeh Najafinezhad

Therapeutic Strategies Targeting the Molecular Pathogenesis of Myotonic Dystrophy Type 1: Current Status and Future Directions

Mol Diagn Ther. 2026 Apr 17. doi: 10.1007/s40291-026-00848-3. Online ahead of print.ABSTRACTMyotonic dystrophy type 1 is the most prevalent adult-onset muscular dystrophy and is characterized by progressive muscle weakness, myotonia, cardiac conduction defects, endocrine dysfunction, and central ner

Mohamed Chahine

Sex-Specific Associations Between Cadmium Exposure and Mortality Risk in Cardiovascular Disease Patients: A Cohort Study Integrating Molecular Mechanisms of Myocardial Dysfunction

No abstractCardiovasc Toxicol. 2026 Apr 17;26(5):45. doi: 10.1007/s12012-026-10117-8.NO ABSTRACTPMID:41996001 | DOI:10.1007/s12012-026-10117-8

Caili He

Sex differences in vascular endothelial function in predicting cardiovascular events in hypertensive patients

Intern Emerg Med. 2026 Apr 17. doi: 10.1007/s11739-026-04311-3. Online ahead of print.ABSTRACTThe prevalence of cardiovascular morbidity and mortality is higher in females than in males, probably for different pathogenetic mechanisms operating in the onset and progression of atherosclerotic vascular

Maria Perticone

Racial Disparities in Biopsychosocial Predictors of Short-Term Smoking Cessation Following Acute Coronary Syndrome Hospitalization

No abstractJ Racial Ethn Health Disparities. 2026 Apr 17. doi: 10.1007/s40615-026-02940-0. Online ahead of print.NO ABSTRACTPMID:41995991 | DOI:10.1007/s40615-026-02940-0

Alex A Ajayi

Targeting the Apelin-APJ Axis: A Promising Strategy to Mitigate Anthracycline-Induced Cardiotoxicity

Cardiovasc Toxicol. 2026 Apr 17;26(5):44. doi: 10.1007/s12012-026-10107-w.ABSTRACTAnthracycline-induced cardiotoxicity remains a major clinical challenge, often progressing to heart failure years after therapy. Conventional cardioprotective agents, including angiotensin-converting enzyme inhibitors,

Varsha G Desai

Short-term modulation of human milk oligosaccharides in plasma and milk by glucose and insulin: insights into postpartum metabolic regulation

Diabetologia. 2026 Apr 17. doi: 10.1007/s00125-026-06729-y. Online ahead of print.ABSTRACTAIMS/HYPOTHESIS: Lactation is associated with reduced maternal risk of future diabetes mellitus and cardiovascular disease. Human milk oligosaccharides (HMOs), bioactive glycans produced in the mammary gland an

Lukas Schönbacher

Empagliflozin improves metabolism and prevents myocardial and coronary dysfunction in streptozotocin-diabetic and non-diabetic rats subjected to ischemia/reperfusion

Basic Res Cardiol. 2026 Apr 17. doi: 10.1007/s00395-026-01177-6. Online ahead of print.ABSTRACTDiabetes heightens cardiovascular risk. The selective sodium-glucose cotransporter 2 inhibitor empagliflozin (EMPA) shows cardiovascular benefits in heart failure, type 2 diabetes and chronic kidney diseas

Carmine Rocca

Association between dynamic serum lactate dehydrogenase levels and functional outcome after endovascular therapy for acute ischemic stroke: A retrospective cohort study

Medicine (Baltimore). 2026 Apr 17;105(16):e48337. doi: 10.1097/MD.0000000000048337.ABSTRACTTo investigate the dynamic changes in serum lactate dehydrogenase (LDH) levels and their association with 90-day functional outcome in patients with large vessel occlusion acute ischemic stroke (LVO-AIS) who u

Renjing Zhu

COMBINED CENTRAL RETINAL ARTERY AND VEIN OCCLUSION-LIKE MANIFESTATIONS WITH APLASTIC ANEMIA: UNVEILING PATHOPHYSIOLOGICAL INSIGHTS

Retin Cases Brief Rep. 2025 Sep;19(5):618-622. doi: 10.1097/ICB.0000000000001612.ABSTRACTPURPOSE: To report the association of a combined central artery and vein occlusion-like pattern with aplastic anemia and discuss the pathophysiology associated with ophthalmologic examinations.METHODS: This stud

Carlos Rodrigo Damasceno Feitosa de Santana

DIET-INDUCED RESOLUTION OF MACULAR OEDEMA FOLLOWING REMISSION OF TYPE 2 DIABETES MELLITUS IN A PATIENT UNDERGOING THERAPEUTIC CARBOHYDRATE REDUCTION

Retin Cases Brief Rep. 2025 Sep;19(5):668-670. doi: 10.1097/ICB.0000000000001614.ABSTRACTPURPOSE: There is growing evidence to support the potential role of low-carbohydrate healthy fat and ketogenic diets (therapeutic carbohydrate reduction - therapeutic carbohydrate reduction) in the management of

Lewis R Hains

Development and Validation of a Health Literacy Scale for Patients With Cardiovascular Disease (HLS-CVD)

Int J Nurs Pract. 2026 Apr;32(2):e70148. doi: 10.1111/ijn.70148.ABSTRACTBACKGROUND: Assessing health literacy has become important as a component of strategies to increase self-care behaviour for patients with cardiovascular disease (CVD).AIM: This study aimed to develop a scale for measuring health

Jeongeun Sim

Transcatheter Intra-Arterial Delivery of a Platelet-Derived Extracellular Vesicle-Enriched Preparation for Attenuating Skeletal Muscle Ischaemia-Reperfusion Injury in a Rodent Forelimb Model

J Extracell Vesicles. 2026 Apr;15(4):e70247. doi: 10.1002/jev2.70247.ABSTRACTExtracellular vesicles (EVs) are non-replicating, lipid membrane-bound nanoparticles released by most eukaryotic cells into the extracellular space. When derived from platelets, a subset of EVs can exhibit remarkable anti-i

Omar A Selim

Safety and Efficacy of Direct Oral Anticoagulants Versus Vitamin K Antagonists for Cerebrovascular Ischemic Outcomes in Non-Valvular Atrial Fibrillation: A Systematic Review and Meta-Analysis

Clin Cardiol. 2026 Apr;49(4):e70308. doi: 10.1002/clc.70308.ABSTRACTBACKGROUND: Atrial fibrillation (AF) is a major cause of thromboembolic events, including ischemic stroke and transient ischemic attack (TIA). While Vitamin K antagonists (VKAs) have long been used for stroke prevention, Direct Oral

Anam Nasir