Adv Gerontol. 2026;39(1):74-81. doi: 10.34922/AE.2026.39.1.008.
ABSTRACT
Aging is recognized as a highly complex process mediated by multiple mechanisms. It affects all body systems, including the cardiovascular system. The severity of age-related changes in the body is often associated with the severity of vascular aging. It remains crucial to analyze current data on vascular aging, tracing the available cause-and-effect relationships of molecular and genetic interactions that are significant for vascular aging. Various studies have confirmed the contribution of various processes and substances to aging, forming a reliable foundation for further gerontological research. Vascular aging is largely associated with the progressive deterioration of endothelial cell function in the vascular intima, leading to impaired production of biologically active substances, causing thrombophilia and increased vascular tone. Endothelial cell aging is largely due to changes in their DNA structure, including telomere shortening and an increase in gene mutations. A comprehensive study of these processes could help us better understand the mechanisms that initiate vascular aging. Furthermore, it is clear that a detailed study of the fundamental intracellular mechanisms underlying vascular aging could help us understand approaches to reducing the incidence of cardiovascular disease with age.
PMID:42150027 | DOI:10.34922/AE.2026.39.1.008