Front Cardiovasc Med. 2026 Jul 13;13:1670562. doi: 10.3389/fcvm.2026.1670562. eCollection 2026.
ABSTRACT
BACKGROUND: The relationship between cumulative triglyceride-glucose-body mass index (TyG-BMI) exposure and the risk of cardiovascular disease (CVD) has been unclear. This study investigated the association between cumulative TyG-BMI exposure and the risk of CVD in the Chinese population using data from the large-scale, prospective community-based Kailuan Study.
METHODS: The Kailuan Study included 47,577 individuals without a history of CVD or cancer who underwent health examinations in 2006, 2008, and 2010. Cumulative TyG-BMI exposure was calculated as the weighted sum of the mean TyG-BMI for each time interval (value × time). Participants were stratified into four groups based on the cumulative TyG-BMI exposure quartile. Cox proportional hazards regression models were established to calculate hazard ratios and 95% confidence intervals for evaluation of the relationship between cumulative TyG-BMI exposure and risk of CVD. The area under the receiver operating characteristic (ROC) curve was calculated to compare the predictive power of cumulative TyG-BMI, TyG, and BMI for CVD.
RESULTS: A total of 3,514 incident cardiovascular events occurred during a median follow-up of 10 years. The risk of CVD increased with increasing cumulative TyG-BMI exposure quartile. After adjusting for potential confounders, Cox regression analysis yielded respective hazard ratios (95% confidence intervals) of 1.32 (1.18-1.49), 1.33 (1.18-1.49), and 1.44 (1.29-1.62) for the Q2, Q3, and Q4 groups in comparison with the Q1 group. The subgroup analysis showed a significant interaction between cumulative TyG-BMI index and age or hypertension, but there was no interaction between sex, Diabetes mellitus and cumulative TyG-BMI index. The restricted cubic spline analysis revealed a significant non-linear relationship between cumulative TyG-BMI index and the risk of CVD. The area under the ROC curve (AUC) of cumulative TyG-BMI was 0.6047, demonstrating modestly higher discriminative performance than TyG (AUC: 0.5602) and BMI (AUC: 0.5612).
CONCLUSIONS: High cumulative TyG-BMI exposure is associated with an increased risk of CVD. The TyG-BMI value may help to identify individuals at high risk of developing CVD.
PMID:42516958 | PMC:PMC13402370 | DOI:10.3389/fcvm.2026.1670562