Braz J Cardiovasc Surg. 2026 May 1;41(3). doi: 10.21470/1678-9741-2025-0303.
ABSTRACT
INTRODUCTION: he CHA2DS2-VA score, which is used to determine the risk of thromboembolism in patients with atrial fibrillation, has been shown to be a predictor of mortality in many cardiovascular diseases. However, there is no data in the literature on the effect of CHA2DS2-VA score on in-hospital mortality in patients with acute aortic dissection (AAD). We aimed to determine the effect of CHA2DS2-VA score on in-hospital mortality in patients with AAD.
METHODS: This retrospective cohort study included 113 patients (89 males, 24 females, age 58.7±10.5 years) who underwent surgical treatment for AAD. CHA2DS2-VA scores were calculated. All cases of in-hospital mortality during the follow-up period were identified and recorded. Patients were grouped as with and without mortality.
RESULTS: Among patients with AAD, in-hospital mortality was observed in 30 cases (27.5%). Mortality rates in patients with CHA2DS2-VA 1, 2, 3 and ≥ 4 were 7%, 13%, 27%, and 53%, respectively. Age, CHA2DS2-VA score, and high-sensitivity C-reactive protein serum level independently determined the patients with mortality, and each one unit increase in these parameters predicted 11.3%, 2.19-fold, and 3.2% mortality increase, respectively. In receiver operating characteristic analysis, when the cutoff value of CHA2DS2-VA score was taken as 3, it was found to determine the development of mortality due to AAD with 80.5% sensitivity and 78.6% specificity.
CONCLUSION: CHA2DS2-VA score is independently associated with the development of in-hospital mortality in patients with AAD. According to the findings of our study, the CHA2DS2-VA score may serve as a prognostic marker in patients with AAD.
PMID:42207177 | DOI:10.21470/1678-9741-2025-0303