Blood Press. 2025 Dec 1:1-12. doi: 10.1080/08037051.2025.2598105. Online ahead of print.
ABSTRACT
Epigenetic modifications are known to contribute to the pathophysiology of hypertension. Only a few studies that have been done to comprehensively evaluate the possibility role of epigenetic changes on the risk of high blood pressure, specifically in children and adolescents. This systematic review study aimed to discuss about the possibility role of epigenetic in hypertension of children and adolescent. This evidence-based research is implemented within the scope of the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) 2020. The data were analyzed qualitatively to assess the risk of bias, with the New Ottawa Scale (NOS) and Agency for Health Research and Quality (AHRQ) criteria as the thresholds. Our research highlights in particular showed that there is a role for epigenetics in hypertension in children and adolescents. Fourteen journals were included to be qualitatively assessed. Eleven journals (78.5%) stated that there was a correlation between epigenetic and blood pressure in children and adolescents, however each study examined different genes or loci. In summary, epigenetic modifications of various single nucleotide polymorphisms (SNPs) and other genes were associated with higher systolic and diastolic blood pressure in children and adolescents.
PMID:41324505 | DOI:10.1080/08037051.2025.2598105