Adv Gerontol. 2026;39(3):371-376. doi: 10.34922/AE.2026.39.3.005.
ABSTRACT
The analysis of the progression of chronic kidney disease (CKD) and cardiovascular events was performed in 318 patients aged 80 years and older during 12 months after myocardial infarction (MI). Patients were divided into 2 groups: with CKD (n=164) and without CKD (n=154). It was found that in patients with CKD, the urinary concentration of KIM-1 and the level of microalbuminuria (UACR) were significantly higher and remained elevated during the year, correlating with the rate of eGFR decline (r=-0,47; p<0,01) and NT-proBNP level. The median time to cardiovascular event in the CKD group was 198 [112; 289] days versus 312 [245; 358] days in the comparison group (p<0,001). The risk of the composite endpoint (death, recurrent MI, stroke) in the CKD group was 2,9 times higher (p<0,001). Independent predictors of adverse outcomes were KIM-1 >1,5 ng/ml (HR=2,3), UACR >30 mg/g (HR=2,1) and anemia (HR=1,8). The obtained data confirm that KIM-1 and microalbuminuria are significant predictors of adverse renal and cardiac prognosis in geriatric patients.
PMID:42502930 | DOI:10.34922/AE.2026.39.3.005