Eur Heart J Case Rep. 2026 Jan 19;10(1):ytaf662. doi: 10.1093/ehjcr/ytaf662. eCollection 2026 Jan.
ABSTRACT
BACKGROUND: Morquio syndrome (MPS IV) is a rare multi-systemic disorder with significant cardiovascular implications, including early-onset valvular disease. Due to the improved life expectancy, these patients could require complex interventional solutions such as TAVI-in-TAVI procedure.
CASE SUMMARY: We present the first reported case of a 65-year-old woman with Morquio syndrome undergoing a TAVI-in-TAVI procedure for structural degeneration of a prior transcatheter bioprosthetic valve. The procedure was technically challenging due to complex thoracic anatomy, small aortic annulus, and intermediate-risk of coronary obstruction. A self-expanding Evolut FX + valve were successfully implanted with favourable haemodynamic outcomes and no major complications.
CONCLUSION: This case highlights the feasibility and importance of individualized planning in complex redo-TAVI interventions in patients with rare congenital disorders.
PMID:41561774 | PMC:PMC12813499 | DOI:10.1093/ehjcr/ytaf662