Replication and compartmentalization of Dobrava-Belgrade virus in the central nervous system

Scritto il 29/05/2026
da Julia Melchert

Emerg Microbes Infect. 2026 Dec;15(1):2673649. doi: 10.1080/22221751.2026.2673649. Epub 2026 May 29.

ABSTRACT

A heart-transplant recipient developed fatal neurologic disease. High-throughput sequencing (HTS) identified Dobrava - Belgrade virus in central nervous system (CNS) and peripheral specimens. Genomic analyzes showed distinct viral populations across compartments, suggesting CNS tropism. This case highlights atypical infection presentations in immunosuppressed patients and underscores the diagnostic value of HTS.

PMID:42213541 | DOI:10.1080/22221751.2026.2673649