ERJ Open Res. 2026 Jun 8;12(3):01213-2025. doi: 10.1183/23120541.01213-2025. eCollection 2026 May.
ABSTRACT
BACKGROUND: Frailty often coexists in patients with COPD regardless of disease severity and may serve as a treatable trait. We hypothesised that factors associated with frailty may differ by COPD severity. This study aimed to comprehensively explore related factors including symptoms, physical activity, dietary behaviour, serum biomarkers and computed tomography (CT) parameters.
METHODS: This cross-sectional analysis of a multicentre prospective cohort study included patients with COPD aged ≥50 years with a smoking history ≥10 pack-years. Frailty was assessed using the Kihon checklist. Data were collected using questionnaires on symptoms, physical activity and dietary behaviour, as well as blood tests and CT parameters. Associations between frailty and clinical variables were assessed using multivariable linear and logistic regressions in all patients and within the COPD severity subgroups.
RESULTS: Among 225 patients, 45 (20%) were diagnosed with frailty. These patients were older, more likely to have cardiovascular disease (CVD) and had a higher neutrophil-to-lymphocyte ratio. Stratified by COPD severity, age, forced expiratory volume in 1 s (FEV1) and calorie intake did not differ by frailty status, whereas patients with frailty exhibited more severe symptoms. In multivariable analysis, frailty was associated with social factors (living alone, unemployment), comorbidities (CVD, gastro-oesophageal reflux disease) and CT airway parameters (wall area percentage (WA%)), but not emphysema, independent of FEV1. Furthermore, living alone was linked to frailty in mild COPD.
CONCLUSION: Social factors, comorbidities and WA% were associated with frailty in patients with COPD. Social factors were more relevant in patients with mild COPD.
PMID:42267375 | PMC:PMC13244204 | DOI:10.1183/23120541.01213-2025