Cancer Invest. 2026 Jun 21:1-14. doi: 10.1080/07357907.2026.2675653. Online ahead of print.
ABSTRACT
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) exhibits extensive immune infiltration, yet the influence of immunological heterogeneity on clinical outcomes remains poorly elucidated.
OBJECTIVES: Addressing the formidable challenge of metastasis suppression in ccRCC treatment.
METHODS: Use scRNA-seq analysis and immunofluorescent imaging to categorize B cells into sub-clusters based on distinct gene expression profiles.
RESULTS: Identify two significant B cell subpopulations, B cell (HLA-DRA) and B cell (FKBP11); show the upregulation of six genes (DERL3, FKBP11, MZB1, TNFSF13B, MYO9B, and ACAP1) in infiltrating B lymphocytes associated with poor prognosis of ccRCC; find that B cell (HLA-DRA) displays a noteworthy association with ccRCC metastasis and demonstrates relevance to tumor immunity across diverse cancers.
CONCLUSIONS: The heterogeneity within B-cell subpopulations may substantially contribute to the metastatic potential of clear cell renal cell carcinoma. The findings provide insights into targeted interventions and improved clinical outcomes.
PMID:42324780 | DOI:10.1080/07357907.2026.2675653