Nutr Metab Cardiovasc Dis. 2026 Feb 26:104642. doi: 10.1016/j.numecd.2026.104642. Online ahead of print.
ABSTRACT
BACKGROUND AND AIMS: Aortic aneurysm (AA) is a significant cardiovascular condition with high mortality and disability burdens. High systolic blood pressure (SBP) is a major modifiable risk factor. This study aims to analyze global and regional trends in the burden of aortic aneurysm attributed to high SBP from 1990 to 2021, using data from the Global Burden of Disease (GBD) study.
METHODS AND RESULTS: We extracted data on disability-adjusted life years (DALYs) and mortality rates of aortic aneurysm attributed to high SBP from the GBD database. Trends were analyzed by socio-demographic index (SDI), region, age, and sex. Spearman correlation, decomposition analysis, and stochastic frontier analysis (SFA) were applied to explore associations and performance gaps. Globally, the DALY rate increased slightly from 6.79 (95% UI: 4.76-9.05) in 1990 to 7.11 (95% UI: 5.33-9.20) in 2021. Mortality rates remained stable (0.34 to 0.36 per 100,000). High-income Asia Pacific and Eastern Europe showed the largest increases, while Australasia and Western Europe saw declines. Males and older adults bore the highest burden. SDI was positively correlated with both DALYs and mortality. Decomposition analysis indicated that population aging and growth were the main drivers of increased burden, while epidemiological changes had protective effects in high-income regions. SFA revealed significant health performance gaps in high-SDI countries like Japan and Armenia.
CONCLUSIONS: Despite global stability, regional disparities in aortic aneurysm burden attributed to high SBP are widening. Interventions should target sex-specific and age-stratified profiles, integrate hypertension control with metabolic risk management, and address health system inefficiencies.
PMID:41935856 | DOI:10.1016/j.numecd.2026.104642