Sensors (Basel). 2026 Mar 20;26(6):1952. doi: 10.3390/s26061952.
ABSTRACT
Surface electromyography (sEMG) provides a non-invasive measure of the neural drive transmitted from the central nervous system to muscles by capturing the spatiotemporal summation of motor unit action potentials at the skin surface, and is therefore widely used to study neuromuscular coordination during motor tasks. By reflecting neural drive transmitted from the central nervous system to peripheral muscles, sEMG provides valuable insights for investigating neuromuscular coordination during upper-limb motor tasks. Within the framework of modular motor control, muscle synergy analysis has been increasingly applied to characterize coordinated muscle activation patterns extracted from multi-channel sEMG recordings. In this study, sEMG signals were collected from twelve stroke patients and nine healthy subjects during robot-assisted upper-limb training, involving two movement trajectories (straight and rectangular) and multiple robot-assisted levels. Muscle synergies were extracted using non-negative matrix factorization (NMF). A synergy merging-splitting model, combined with a Functional Driving Ratio (FDR), was employed to characterize both the muscle synergy reorganization and the relative activation contributions of driving versus stabilizing muscle components in terms of motor control strategy. The results showed that healthy subjects maintained consistent muscle coordination patterns across different assistive levels, while making task-dependent adjustments to muscle activation to adapt to variations in movement trajectories. For stroke patients, higher functional status was correlated with more differentiated coordination patterns and relatively higher FDR values, suggesting greater reliance on task-relevant agonist muscles during movement execution. In contrast, lower-function patients exhibited less differentiated coordination patterns accompanied by reduced FDR values, indicating the increased involvement of stabilizing or antagonist muscles. This shift may reflect compensatory control strategies and the reduced efficiency of neuromuscular coordination during assisted upper-limb movements. These findings suggest that sEMG-based muscle synergy features and the FDR may provide quantitative, sensor-derived support for characterizing neuromuscular coordination during robot-assisted rehabilitation.
PMID:41902120 | DOI:10.3390/s26061952