Aging Male. 2026 Dec 31;29(1):2625508. doi: 10.1080/13685538.2026.2625508. Epub 2026 Feb 8.
ABSTRACT
BACKGROUND: The present study aims to investigate the associations between the allostatic load index (ALI), prostate-specific antigen (PSA) levels, and certain causes of death among the participants.
METHODS: Participants in this study were selected from the NHANES database (2003-2010) and linked to mortality files (the National Death Index, 2003-2010). Multivariate Cox proportional hazards models were used to analyze the effect of the allostatic load (AL) on PSA levels and all-cause mortality in participants.
RESULTS: This study found that an increase in ALI exerted a certain impact on PSA levels in the entire participant population (especially in the subgroup with WWI < 0.5). Participants in the third quartile (T3) with the highest ALI index had a significantly 52% increased probability of all-cause mortality compared to those in T1 (OR = 1.52, 95% CI: 1.28, 1.76, P < 0.01). Both RCS analysis and the K-M curve provide corroboration. When treated as a continuous variable, it is also associated with cardiac mortality (OR = 1.14, 95% CI: 1.04, 1.26, P < 0.01).
CONCLUSIONS: In a specific range, higher ALI was significantly and positively associated with PSA levels, all-cause mortality, and cardiovascular disease risk, though its link to cancer-specific mortality risk was not statistically significant in this study.
PMID:41656497 | DOI:10.1080/13685538.2026.2625508