Diabetes. 2026 Jun 16:db250859. doi: 10.2337/db25-0859. Online ahead of print.
ABSTRACT
Ribosomal S6 kinase 4 (Rsk4) is predominantly expressed in hypothalamic neurons. Rsk4 is negligible for maintaining energy homeostasis in mice. Loss of Rsk4 promotes diet-induced obesity and related metabolic disorders in mice. Rsk4 is required for central fibroblast growth factor-19 to reduce body weight in obese mice.
PMID:42301138 | DOI:10.2337/db25-0859