Free Radic Biol Med. 2025 Dec 31:S0891-5849(25)01449-2. doi: 10.1016/j.freeradbiomed.2025.12.040. Online ahead of print.
ABSTRACT
Wang and colleagues (Wang, et al, Free Rad Biol Med, 242 (2026) 167-187) have found in in silico and in vitro experiments, that multifaceted molecule genistein inhibits many of the detrimental effects of high glucose in a C. elegans-based Alzheimer disease model that expresses β-amyloid in a temperature-dependent fashion. Genistein inhibits, amongst many other pathophysiogical parameters, the glucose-induced aggregation of β-amyloid. While these findings are of interest, a few possible explanations are missing. Here, we hypothesize that genistein may inhibit some of the high glucose effects through its previously described inhibitory interaction with glucose transporters.
PMID:41482083 | DOI:10.1016/j.freeradbiomed.2025.12.040