Int J Numer Method Biomed Eng. 2026 Jan;42(1):e70128. doi: 10.1002/cnm.70128.
ABSTRACT
Fontan-associated liver disease (FALD) is a disorder arising from hemodynamic changes and venous congestion in the liver. This disease is prominent in patients with hypoplastic left heart syndrome (HLHS). Although HLHS patients typically survive into adulthood, they have reduced cardiac output due to their univentricular physiology (i.e., a Fontan circuit). As a result, they have insufficient blood delivery to the liver. In comparison, patients with double outlet right ventricle (DORV), also having a univentricular circuit, have a lower incidence of FALD. In this study, we use a patient-specific, one-dimensional computational fluid dynamics (1D-CFD) model to predict hemodynamics in the liver of an HLHS patient and compare the predictions with an age- and size-matched single-ventricle Fontan DORV control patient. Additionally, we simulate FALD conditions in the HLHS patient to predict hemodynamic changes across various stages of disease progression. Our results show that the HLHS patient has higher hepatic arterial pressure compared to the DORV patient. This difference is exacerbated as FALD conditions progress. HLHS patients also have higher average portal pressures than DORV patients. The wall shear stress (WSS) is higher in the hepatic network for the simulated FALD patients. WSS is slightly decreased in the portal network for the HLHS patients, consistent with the development of portal hypertension. Perfusion analysis gives insight into regions of liver tissue at risk for fibrosis development, showing increasing pressures and reduced flow throughout the liver tissue fed by the portal vein under FALD conditions. Our results provide insight into the specific hemodynamic changes in Fontan circulation that can cause FALD.
PMID:41521410 | DOI:10.1002/cnm.70128