Endocrinol Diabetes Metab. 2026 May;9(3):e70230. doi: 10.1002/edm2.70230.
ABSTRACT
INTRODUCTION: This critique examines the methodological quality of a recent study by Shahid et al. on mortality trends related to peripheral circulatory complications in patients with type 2 diabetes mellitus using the CDC WONDER database.
METHODS: We critically appraised the original study's methodology, including the consistency of reported mortality rates, age group data presentation, classification of urban and rural areas, reporting of race and ethnicity data, place of death analysis and causal inferences drawn from the ecological design.
RESULTS: Several methodological shortcomings were identified: inconsistent reporting of mortality rate denominators (per 100,000 vs. per 1,000,000 population); selective reporting of age group data in the main text; use of a non-standard threshold (500,000 population) for classifying urban and rural areas; inconsistent use of the 'Non-Hispanic' qualifier for race and ethnicity categories; percentages summing to over 100% in the place of death analysis; and unsupported causal claims in the discussion.
CONCLUSIONS: While the original study addresses an important public health concern, the identified methodological issues limit the interpretability of its findings. Addressing these concerns through consistent denominators, complete age-stratified reporting and standard classifications would strengthen future research in this area.
PMID:42060514 | DOI:10.1002/edm2.70230