Heart Vessels. 2026 Apr 5. doi: 10.1007/s00380-026-02686-z. Online ahead of print.
ABSTRACT
The clinical outcomes of acute myocardial infarction (AMI) in dialysis patients are poor, and the outcomes may be worse in the long-term dialysis patients due to diabetic nephropathy (DMN). However, there are limited reports on the in-hospital outcomes of dialysis patients with AMI considering the underlying disease and duration of dialysis. This retrospective study aimed to compare the in-hospital outcomes in dialysis patients who underwent percutaneous coronary intervention (PCI) for AMI between with and without long-term dialysis due to DMN. We included 239 dialysis patients with AMI and divided them into the long-DMN group (n = 101) and the other group (n = 138) according to the presence or absence of the combination of DMN and ≥ 3 years duration of dialysis. The long-DMN group had significantly advanced Killip class and the higher prevalence of cardiac arrest at prehospital, lower left ventricular ejection fraction, and more frequent multivessel disease and severe calcification. The incidence of in-hospital death was significantly higher in the long-DMN group (14.9%) than in the other group (5.8%) (p = 0.026). In multivariate analysis, long-DMN was significantly associated with in-hospital death (OR 2.601, 95% CI 1.047-6.464, p = 0.040) after controlling for age and sex. AMI patients with long-term dialysis due to DMN had the higher in-hospital death rate than those with other dialysis status. Long-term dialysis due to DMN may be associated with in-hospital outcomes in dialysis patients with AMI.
PMID:41936671 | DOI:10.1007/s00380-026-02686-z