JACC Asia. 2025 Dec 4:S2772-3747(25)00596-4. doi: 10.1016/j.jacasi.2025.10.017. Online ahead of print.
ABSTRACT
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, with their prevalence rising with advancing age. Progressive remodeling of the cardiovascular system during aging underlies increased vulnerability to cardiovascular pathologies. This review summarizes current insights into the structural, functional, and molecular hallmarks of both cardiovascular aging (CVA) and CVDs, highlighting their mechanistic convergence. By further discussing diagnostic biomarkers and intervention strategies that bridge these processes, we delineated the translational continuum linking CVA and CVDs. The understanding of their interconnections underscores the potential of targeting CVA as a strategy for CVD prevention, early diagnosis, and treatment.
PMID:41379057 | DOI:10.1016/j.jacasi.2025.10.017