Sport Sci Health. 2026;22(3):300. doi: 10.1007/s11332-026-01863-x. Epub 2026 Aug 6.
ABSTRACT
AIM: Low moderate-to-vigorous physical activity (MVPA), high sedentary behavior (SB), and inadequate sleep are individually associated with type 2 diabetes (T2D) risk. However, the aggregate impact of these movement patterns remains unclear.
PURPOSE: Assess whether being aligned with 24-h movement guidelines of MVPA, SB, and sleep relates to cardiometabolic health, and compare this with the American Heart Association's Life's Essential 8.
METHODS: In a cross-sectional study, adults with obesity [n = 56 (39 F); 55.6 ± 1.1 y; 34.5 ± 0.7 kg/m2] with low 24-h movement z-scores ["aligned"; n = 28 (21 F)] were compared to those with high z-scores ["misaligned" n = 28 (18 F)]. MVPA and SB (accelerometer) and sleep (Pittsburgh Sleep Quality Index) were assessed to calculate z scores. LE8 scores were calculated according to AHA guidelines. A 120-min hyperinsulinemic-euglycemic clamp (40 mU/m2/min, 90 mg/dl) with indirect calorimetry was used to determine metabolic insulin sensitivity [glucose infusion rate (GIR)] and substrate oxidation. Pulse wave velocity and augmentation index (AIx75) were assessed at 0 and 120 min of the clamp to assess arterial stiffness. Fitness (VO2max) and body fat (DXA) were also assessed.
RESULTS: Despite no differences in age, body fat, or VO2max, the misaligned group had higher fasting DBP, MAP, and AIx75 (P < 0.05), lower GIR (P = 0.07), and lower FFA suppression (P = 0.01). While both the z-score and LE8 related to blood pressure, only the z-score correlated with AIx75 and FFA suppression.
CONCLUSION: Aligning with 24-h movement patterns related to better cardiometabolic health in people with obesity.
CLINICAL TRIALS REGISTRATION: NCT03355469.
PMID:42568642 | PMC:PMC13447396 | DOI:10.1007/s11332-026-01863-x